pravastatin ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antihyperlipidaemic substances, HMG CoA reductase inhibitors 2239 81093-37-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pravastatin
  • eptastatin
  • mevalothin
  • pravastatin acid
  • pravastatin sodium
  • pravachol
An antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES).
  • Molecular weight: 424.53
  • Formula: C23H36O7
  • CLOGP: 2.05
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 4
  • TPSA: 124.29
  • ALOGS: -3.24
  • ROTB: 11

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
30 mg O

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.57 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Hosey CM, Chan R, Benet LZ
S (Water solubility) 300 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 47 % Hosey CM, Chan R, Benet LZ
BA (Bioavailability) 18 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.46 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 14 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.50 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.78 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Oct. 31, 1991 FDA BRISTOL MYERS SQUIBB

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myalgia 223.61 10.68 417 51518 146112 63290975
Contraindicated product administered 136.68 10.68 11 51924 217637 63219450
Hand deformity 116.28 10.68 3 51932 159454 63277633
Acute kidney injury 113.43 10.68 471 51464 262944 63174143
Systemic lupus erythematosus 108.21 10.68 20 51915 208898 63228189
Synovitis 103.26 10.68 15 51920 186903 63250184
Glossodynia 97.32 10.68 15 51920 178861 63258226
Product dose omission issue 90.09 10.68 405 51530 233908 63203179
Drug ineffective 88.37 10.68 499 51436 1044266 62392821
Pericarditis 87.39 10.68 5 51930 131574 63305513
Maternal exposure during pregnancy 84.67 10.68 37 51898 220025 63217062
Treatment failure 82.25 10.68 30 51905 199013 63238074
Wound 79.61 10.68 18 51917 163245 63273842
Lower respiratory tract infection 72.17 10.68 11 51924 132296 63304791
Fall 67.72 10.68 550 51385 391784 63045303
Hyperkalaemia 64.25 10.68 139 51796 54064 63383023
Atrioventricular block second degree 64.22 10.68 40 51895 3874 63433213
Infusion related reaction 63.83 10.68 64 51871 245457 63191630
Arthropathy 63.60 10.68 59 51876 234733 63202354
Exposure during pregnancy 63.31 10.68 24 51911 155523 63281564
Discomfort 58.51 10.68 32 51903 167342 63269745
Duodenal ulcer perforation 55.86 10.68 4 51931 87205 63349882
Drug intolerance 53.83 10.68 107 51828 308554 63128533
Lactic acidosis 53.39 10.68 105 51830 38182 63398905
Muscle spasms 52.69 10.68 260 51675 155890 63281197
Diarrhoea 52.05 10.68 847 51088 714519 62722568
Swelling 51.05 10.68 92 51843 275286 63161801
Pulseless electrical activity 48.73 10.68 44 51891 7477 63429610
Myopathy 45.77 10.68 51 51884 11140 63425947
Bezoar 45.27 10.68 23 51912 1503 63435584
Insulin autoimmune syndrome 41.57 10.68 11 51924 103 63436984
Therapeutic product effect decreased 41.00 10.68 59 51876 193128 63243959
Hepatic enzyme increased 40.80 10.68 64 51871 202264 63234823
Full blood count decreased 40.77 10.68 75 51860 25949 63411138
Folliculitis 40.33 10.68 5 51930 70312 63366775
Joint swelling 39.26 10.68 137 51798 327529 63109558
Chronic kidney disease 39.25 10.68 103 51832 45295 63391792
Psoriasis 36.93 10.68 155 51780 86802 63350285
Decreased bronchial secretion 36.45 10.68 9 51926 62 63437025
Alopecia 35.98 10.68 148 51787 337388 63099699
Congenital coronary artery malformation 34.26 10.68 10 51925 138 63436949
Drug abuse 33.37 10.68 9 51926 72509 63364578
Drug hypersensitivity 32.64 10.68 393 51542 310294 63126793
Colitis microscopic 32.23 10.68 39 51896 9300 63427787
Blood thyroid stimulating hormone normal 31.54 10.68 9 51926 114 63436973
Impaired healing 31.16 10.68 23 51912 102519 63334568
Abdominal discomfort 30.98 10.68 146 51789 320739 63116348
Hyponatraemia 30.67 10.68 176 51759 111724 63325363
Rhabdomyolysis 30.43 10.68 92 51843 43859 63393228
Acute interstitial pneumonitis 28.10 10.68 13 51922 691 63436396
Hypersensitivity 25.49 10.68 138 51797 292547 63144540
Immune-mediated myositis 25.31 10.68 15 51920 1328 63435759
Blood glucose increased 25.12 10.68 135 51800 83621 63353466
Asthenia 24.77 10.68 446 51489 383158 63053929
Toxicity to various agents 24.74 10.68 111 51824 247139 63189948
Electrocardiogram PR prolongation 24.70 10.68 12 51923 712 63436375
Interstitial lung disease 24.47 10.68 108 51827 61800 63375287
Ill-defined disorder 23.99 10.68 19 51916 81736 63355351
Anaemia 23.70 10.68 354 51581 293076 63144011
Completed suicide 23.26 10.68 53 51882 145620 63291467
Atrioventricular block first degree 22.89 10.68 29 51906 7244 63429843
Atrial fibrillation 22.51 10.68 168 51767 116468 63320619
Rheumatoid arthritis 22.47 10.68 119 51816 253700 63183387
Gastrointestinal disorder 22.41 10.68 46 51889 131193 63305894
Muscular weakness 22.37 10.68 174 51761 122179 63314908
Decreased appetite 22.30 10.68 308 51627 250744 63186343
Musculoskeletal stiffness 22.21 10.68 77 51858 184541 63252546
Vertigo 21.82 10.68 102 51833 59785 63377302
Blister 21.74 10.68 46 51889 129768 63307319
Muscle rupture 21.40 10.68 17 51918 2426 63434661
Malaise 21.28 10.68 467 51468 415487 63021600
Hip arthroplasty 19.97 10.68 7 51928 47639 63389448
Post viral fatigue syndrome 19.69 10.68 8 51927 309 63436778
Adenocarcinoma metastatic 19.40 10.68 6 51929 102 63436985
Diabetic ketoacidosis 19.25 10.68 48 51887 20457 63416630
Red blood cell sedimentation rate increased 19.24 10.68 6 51929 43976 63393111
Memory impairment 18.90 10.68 148 51787 104110 63332977
Infection 18.88 10.68 110 51825 229063 63208024
Device expulsion 18.81 10.68 3 51932 34919 63402168
Alexithymia 18.33 10.68 3 51932 0 63437087
Pancreatic steatosis 18.24 10.68 11 51924 1005 63436082
Axonal neuropathy 18.18 10.68 11 51924 1011 63436076
Suicide attempt 18.07 10.68 14 51921 60904 63376183
Renal tubular disorder 17.99 10.68 16 51919 2666 63434421
Haematoma 17.96 10.68 66 51869 34754 63402333
Vitamin B12 decreased 17.45 10.68 18 51917 3602 63433485
Intertrigo 17.45 10.68 9 51926 607 63436480
Cerebral haemorrhage 17.35 10.68 60 51875 30669 63406418
Laryngitis 17.30 10.68 41 51894 16926 63420161
Glycosylated haemoglobin increased 17.28 10.68 34 51901 12364 63424723
Urinary tract infection 17.15 10.68 308 51627 264376 63172711
Fixed eruption 16.87 10.68 11 51924 1153 63435934
Sinus arrhythmia 16.79 10.68 12 51923 1461 63435626
Cholestatic liver injury 16.38 10.68 15 51920 2595 63434492
Hepatotoxicity 16.30 10.68 5 51930 37036 63400051
Myositis 16.17 10.68 28 51907 9238 63427849
Muscle injury 15.87 10.68 18 51917 65327 63371760
Gastrointestinal haemorrhage 15.70 10.68 117 51818 81059 63356028
Inflammation 15.66 10.68 27 51908 82246 63354841
Cerebral infarction 15.59 10.68 49 51886 23844 63413243
Blood loss anaemia 15.45 10.68 27 51908 8974 63428113
Drug interaction 15.32 10.68 268 51667 228863 63208224
Nasal congestion 15.27 10.68 99 51836 65561 63371526
Product dispensing error 15.26 10.68 29 51906 10276 63426811
Melaena 15.20 10.68 57 51878 30308 63406779
Cutaneous T-cell lymphoma 15.17 10.68 11 51924 1369 63435718
Urinary incontinence 15.12 10.68 59 51876 31955 63405132
Product use issue 15.05 10.68 112 51823 220408 63216679
Cardiac failure congestive 15.02 10.68 128 51807 92305 63344782
Hepatitis cholestatic 15.01 10.68 23 51912 6855 63430232
Restless legs syndrome 14.96 10.68 41 51894 18490 63418597
Mobility decreased 14.92 10.68 50 51885 121109 63315978
Loss of consciousness 14.91 10.68 155 51780 117966 63319121
Cardiac murmur functional 14.88 10.68 4 51931 40 63437047
Eczema 14.84 10.68 59 51876 32232 63404855
Ear haemorrhage 14.75 10.68 11 51924 1429 63435658
Pain in extremity 14.72 10.68 365 51570 331121 63105966
Viral infection 14.69 10.68 63 51872 35600 63401487
Haematoma muscle 14.68 10.68 10 51925 1127 63435960
Gastric infection 14.45 10.68 16 51919 3471 63433616
Pancreatitis acute 14.44 10.68 52 51883 27114 63409973
Scratch 14.40 10.68 22 51913 6543 63430544
Liver injury 14.35 10.68 17 51918 60503 63376584
Transient ischaemic attack 14.27 10.68 65 51870 37688 63399399
Essential hypertension 14.18 10.68 19 51916 5014 63432073
Dry gangrene 14.11 10.68 8 51927 652 63436435
Tubulointerstitial nephritis 14.09 10.68 42 51893 19861 63417226
Iron deficiency anaemia 14.01 10.68 42 51893 19927 63417160
Priapism 14.00 10.68 5 51930 135 63436952
Vessel puncture site bruise 13.99 10.68 7 51928 443 63436644
Bronchitis 13.95 10.68 160 51775 124775 63312312
Potassium wasting nephropathy 13.92 10.68 4 51931 52 63437035
Poor dental condition 13.70 10.68 7 51928 463 63436624
Pericardial haemorrhage 13.61 10.68 11 51924 1608 63435479
Loss of personal independence in daily activities 13.51 10.68 38 51897 97252 63339835
Skin depigmentation 13.41 10.68 9 51926 990 63436097
Influenza 13.41 10.68 142 51793 108580 63328507
Blood folate decreased 13.22 10.68 8 51927 736 63436351
Injury 13.08 10.68 25 51910 73222 63363865
Mammogram abnormal 13.05 10.68 8 51927 753 63436334
Bacteriuria 12.98 10.68 9 51926 1044 63436043
Ligament rupture 12.95 10.68 15 51920 3415 63433672
Heart rate abnormal 12.91 10.68 18 51917 4929 63432158
Myopathy toxic 12.91 10.68 7 51928 523 63436564
Fanconi syndrome 12.87 10.68 10 51925 1382 63435705
Dysmetria 12.82 10.68 7 51928 530 63436557
Sedation 12.73 10.68 8 51927 38801 63398286
COVID-19 immunisation 12.66 10.68 11 51924 1776 63435311
Hyperlipidaemia 12.64 10.68 40 51895 19531 63417556
Hypoacusis 12.64 10.68 46 51889 24105 63412982
Constipation 12.59 10.68 256 51679 224687 63212400
Arterial thrombosis 12.55 10.68 10 51925 1433 63435654
Hypovolaemic shock 12.42 10.68 20 51915 6221 63430866
Alanine aminotransferase 12.37 10.68 4 51931 79 63437008
Cholestasis 12.12 10.68 52 51883 29382 63407705
Uterine dilation and evacuation 12.11 10.68 3 51932 21 63437066
Off label use 12.06 10.68 441 51494 674021 62763066
General physical health deterioration 12.04 10.68 106 51829 201296 63235791
Respiratory arrest 11.75 10.68 6 51929 32639 63404448
C-reactive protein increased 11.72 10.68 39 51896 94668 63342419
Cerebral mass effect 11.72 10.68 8 51927 905 63436182
Angular cheilitis 11.57 10.68 7 51928 644 63436443
Pain 11.56 10.68 492 51443 740136 62696951
Hypochloraemia 11.56 10.68 11 51924 1998 63435089
Angina pectoris 11.52 10.68 52 51883 30026 63407061
Fibromyalgia 11.47 10.68 31 51904 80389 63356698
Lower gastrointestinal haemorrhage 11.44 10.68 22 51913 7868 63429219
Mucosal inflammation 11.32 10.68 13 51922 46915 63390172
Myxoedema 11.30 10.68 4 51931 105 63436982
Low density lipoprotein decreased 11.30 10.68 5 51930 239 63436848
Papillitis 11.25 10.68 3 51932 29 63437058
Dysgeusia 11.21 10.68 71 51864 46639 63390448
Back pain 11.17 10.68 289 51646 263856 63173231
Vitamin B6 deficiency 11.16 10.68 4 51931 109 63436978
Diabetes mellitus 11.11 10.68 81 51854 55729 63381358
Pulmonary renal syndrome 11.07 10.68 6 51929 448 63436639
Ocular retrobulbar haemorrhage 11.06 10.68 4 51931 112 63436975
Enteritis infectious 11.04 10.68 11 51924 2113 63434974
Epistaxis 10.93 10.68 99 51836 72626 63364461
Presbyopia 10.86 10.68 6 51929 465 63436622
Leukocytosis 10.82 10.68 46 51889 25889 63411198
Myelosuppression 10.79 10.68 3 51932 23700 63413387
Febrile neutropenia 10.77 10.68 55 51880 118394 63318693

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myalgia 191.50 10.76 347 40220 83763 34832601
Acute kidney injury 72.45 10.76 602 39965 304386 34611978
IgM nephropathy 71.91 10.76 19 40548 119 34916245
Drug abuse 71.64 10.76 14 40553 99082 34817282
Blood creatine phosphokinase increased 50.66 10.76 140 40427 44717 34871647
Shone complex 50.56 10.76 13 40554 72 34916292
Myopathy 47.92 10.76 63 40504 11491 34904873
Fall 39.07 10.76 383 40184 202502 34713862
Interstitial lung disease 38.51 10.76 164 40403 65118 34851246
Drug interaction 37.12 10.76 413 40154 225533 34690831
Supravalvular aortic stenosis 35.60 10.76 9 40558 46 34916318
Aorta hypoplasia 35.29 10.76 10 40557 84 34916280
Puncture site haematoma 34.29 10.76 11 40556 146 34916218
Intestinal atony 34.08 10.76 8 40559 28 34916336
Drug ineffective 32.73 10.76 356 40211 456395 34459969
Intraocular haematoma 32.65 10.76 7 40560 14 34916350
Exercise lack of 31.65 10.76 10 40557 126 34916238
Muscle rupture 31.41 10.76 24 40543 2274 34914090
Lactic acidosis 31.15 10.76 100 40467 34672 34881692
Angina pectoris 29.75 10.76 92 40475 31271 34885093
Diaphragmatic disorder 28.46 10.76 18 40549 1257 34915107
Completed suicide 28.12 10.76 44 40523 98124 34818240
Phaeochromocytoma malignant 27.74 10.76 8 40559 72 34916292
Hepatocellular injury 25.74 10.76 70 40497 22141 34894223
Congenital heart valve disorder 25.12 10.76 7 40560 55 34916309
Cholestasis 24.59 10.76 78 40489 26870 34889494
Hyperkinetic heart syndrome 24.04 10.76 8 40559 120 34916244
Febrile neutropenia 24.03 10.76 80 40487 136769 34779595
Pemphigoid 23.92 10.76 39 40528 8627 34907737
Muscle spasms 23.91 10.76 159 40408 74842 34841522
Left ventricular hypertrophy 23.01 10.76 37 40530 8093 34908271
Off label use 22.59 10.76 347 40220 419177 34497187
Congenital aortic anomaly 22.39 10.76 7 40560 85 34916279
Gastritis fungal 22.39 10.76 7 40560 85 34916279
Mitral valve hypoplasia 22.39 10.76 6 40561 40 34916324
Coma uraemic 22.26 10.76 6 40561 41 34916323
Pericarditis fungal 22.20 10.76 8 40559 154 34916210
Renal-limited thrombotic microangiopathy 21.95 10.76 7 40560 91 34916273
Femoral artery aneurysm 21.68 10.76 8 40559 165 34916199
AST/ALT ratio abnormal 21.64 10.76 5 40562 16 34916348
Nephrogenic anaemia 21.61 10.76 19 40548 2192 34914172
Pseudolymphoma 21.58 10.76 12 40555 660 34915704
Tendon rupture 21.35 10.76 33 40534 6979 34909385
Cerebral haematoma 20.44 10.76 26 40541 4589 34911775
Cerebrovascular accident 20.31 10.76 168 40399 84643 34831721
Chest wall haematoma 20.25 10.76 8 40559 200 34916164
Treatment failure 19.94 10.76 15 40552 46682 34869682
Dependence on oxygen therapy 19.78 10.76 8 40559 213 34916151
Coarctation of the aorta 19.53 10.76 10 40557 465 34915899
Aortic occlusion 19.03 10.76 6 40561 75 34916289
Suicide attempt 18.82 10.76 11 40556 39105 34877259
Carnitine palmitoyltransferase deficiency 18.66 10.76 4 40563 8 34916356
Hyperkalaemia 18.56 10.76 141 40426 69248 34847116
Subdural haematoma 18.53 10.76 59 40508 20362 34896002
Eosinophilic pleural effusion 18.18 10.76 8 40559 264 34916100
Sepsis 18.14 10.76 116 40451 166445 34749919
Gait disturbance 17.96 10.76 164 40403 84976 34831388
Eczema 17.40 10.76 54 40513 18382 34897982
Toxicity to various agents 17.30 10.76 149 40418 200213 34716151
Xerosis 17.28 10.76 10 40557 594 34915770
Peripheral swelling 16.94 10.76 149 40418 76392 34839972
Intensive care unit acquired weakness 16.91 10.76 12 40555 1015 34915349
Haemorrhagic transformation stroke 16.74 10.76 14 40553 1509 34914855
Renal arteriosclerosis 16.68 10.76 7 40560 205 34916159
Hyperlactacidaemia 16.65 10.76 19 40548 2997 34913367
Foetal exposure during pregnancy 16.58 10.76 12 40555 38089 34878275
Neutrophil count decreased 16.52 10.76 21 40546 51083 34865281
Toxic optic neuropathy 16.52 10.76 11 40556 839 34915525
Diarrhoea 16.44 10.76 579 39988 389333 34527031
Lupus-like syndrome 16.30 10.76 18 40549 2738 34913626
Akinesia 16.02 10.76 16 40551 2168 34914196
Loss of control of legs 15.50 10.76 10 40557 723 34915641
Myotonic dystrophy 15.45 10.76 6 40561 143 34916221
Peripheral artery occlusion 15.32 10.76 14 40553 1698 34914666
Congenital aortic valve stenosis 15.15 10.76 6 40561 151 34916213
Transaminases abnormal 15.11 10.76 7 40560 261 34916103
Cell death 15.00 10.76 16 40551 2341 34914023
Heart transplant rejection 14.97 10.76 12 40555 1219 34915145
Thrombotic stroke 14.89 10.76 7 40560 270 34916094
Hypoparathyroidism 14.66 10.76 9 40558 596 34915768
Hepatitis fulminant 14.59 10.76 21 40546 4169 34912195
Anti factor VIII antibody positive 14.50 10.76 5 40562 84 34916280
Eosinophilic pneumonia 14.37 10.76 19 40548 3482 34912882
Glycosylated haemoglobin increased 14.37 10.76 37 40530 11323 34905041
Congenital aortic stenosis 14.13 10.76 5 40562 91 34916273
Acute respiratory failure 14.03 10.76 72 40495 30856 34885508
Arteriovenous fistula 13.87 10.76 11 40556 1100 34915264
Toxic epidermal necrolysis 13.78 10.76 4 40563 21642 34894722
Therapeutic drug monitoring analysis incorrectly performed 13.76 10.76 7 40560 321 34916043
Premature baby 13.71 10.76 3 40564 19630 34896734
Orthostatic tremor 13.68 10.76 3 40564 7 34916357
Dysgeusia 13.68 10.76 64 40503 26433 34889931
Fatigue 13.35 10.76 541 40026 370112 34546252
Meningitis fungal 13.25 10.76 5 40562 110 34916254
Conjunctival haemorrhage 13.20 10.76 17 40550 3038 34913326
Bladder cyst 13.04 10.76 5 40562 115 34916249
Chronic kidney disease 12.90 10.76 87 40480 41123 34875241
Blood loss anaemia 12.85 10.76 29 40538 8165 34908199
Intraventricular haemorrhage 12.74 10.76 18 40549 3513 34912851
Rhabdomyolysis 12.74 10.76 128 40439 68035 34848329
Electrocardiogram ST segment depression 12.70 10.76 15 40552 2453 34913911
Agitation 12.70 10.76 30 40537 57369 34858995
Disease progression 12.41 10.76 74 40493 108003 34808361
Hepatitis cholestatic 12.32 10.76 28 40539 7919 34908445
Brain injury 12.27 10.76 24 40543 6118 34910246
Echocardiogram abnormal 12.16 10.76 10 40557 1053 34915311
Ketonuria 12.10 10.76 8 40559 603 34915761
Hypoxic-ischaemic encephalopathy 11.98 10.76 20 40547 4512 34911852
Multiple organ dysfunction syndrome 11.94 10.76 47 40520 76519 34839845
Heart disease congenital 11.73 10.76 11 40556 1379 34914985
Drug eruption 11.73 10.76 50 40517 19848 34896516
Neutropenia 11.63 10.76 121 40446 156657 34759707
Infusion related reaction 11.52 10.76 28 40539 53029 34863335
Drug resistance 11.50 10.76 8 40559 25919 34890445
Oedema peripheral 11.44 10.76 199 40368 119613 34796751
Myoglobin urine 11.33 10.76 3 40564 19 34916345
Thrombocytopenia 11.02 10.76 122 40445 156125 34760239
Food interaction 10.98 10.76 9 40558 944 34915420
Atrial hypertrophy 10.95 10.76 3 40564 22 34916342
Limb injury 10.81 10.76 34 40533 11655 34904709
Splenic vein thrombosis 10.81 10.76 7 40560 509 34915855
Inappropriate antidiuretic hormone secretion 10.81 10.76 36 40531 12717 34903647
Gross motor delay 10.79 10.76 6 40561 330 34916034

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myalgia 317.83 9.89 614 77204 185027 79481543
Acute kidney injury 188.65 9.89 1001 76817 518403 79148167
Synovitis 95.71 9.89 16 77802 150718 79515852
Drug abuse 95.40 9.89 21 77797 162670 79503900
Drug ineffective 94.64 9.89 643 77175 1080270 78586300
Contraindicated product administered 93.06 9.89 20 77798 157518 79509052
Fall 91.09 9.89 798 77020 486831 79179739
Hand deformity 87.91 9.89 3 77815 103916 79562654
Lactic acidosis 85.84 9.89 203 77615 70156 79596414
Hyperkalaemia 83.83 9.89 274 77544 114124 79552446
Myopathy 77.53 9.89 98 77720 20465 79646105
IgM nephropathy 75.18 9.89 19 77799 119 79666451
Treatment failure 73.85 9.89 37 77781 170449 79496121
Maternal exposure during pregnancy 71.70 9.89 22 77796 136516 79530054
Pericarditis 70.95 9.89 9 77809 104227 79562343
Infusion related reaction 65.36 9.89 77 77741 230160 79436410
Interstitial lung disease 63.89 9.89 248 77570 112352 79554218
Exposure during pregnancy 59.39 9.89 13 77805 101119 79565451
Glossodynia 59.25 9.89 14 77804 103323 79563247
Lower respiratory tract infection 59.11 9.89 26 77792 129194 79537376
Drug interaction 58.12 9.89 640 77178 414543 79252027
Muscle spasms 57.26 9.89 328 77490 174402 79492168
Systemic lupus erythematosus 56.01 9.89 24 77794 121125 79545445
Arthropathy 54.95 9.89 55 77763 177056 79489514
Completed suicide 54.25 9.89 98 77720 245669 79420901
Blood creatine phosphokinase increased 51.76 9.89 162 77656 65928 79600642
Helicobacter infection 47.48 9.89 6 77812 69698 79596872
Duodenal ulcer perforation 46.84 9.89 5 77813 66206 79600364
Wound 44.88 9.89 29 77789 116150 79550420
Joint swelling 44.63 9.89 139 77679 288507 79378063
Toxicity to various agents 43.87 9.89 237 77581 421303 79245267
Atrioventricular block second degree 41.38 9.89 43 77775 7269 79659301
Cholestasis 40.13 9.89 127 77691 51982 79614588
Rhabdomyolysis 38.75 9.89 201 77617 102930 79563640
Therapeutic product effect decreased 35.56 9.89 66 77752 163797 79502773
Diarrhoea 34.93 9.89 1114 76704 879375 78787195
Congenital coronary artery malformation 34.93 9.89 10 77808 106 79666464
Drug intolerance 34.89 9.89 136 77682 263983 79402587
Muscle rupture 34.85 9.89 29 77789 3698 79662872
Eczema 34.71 9.89 103 77715 40715 79625855
Decreased bronchial secretion 34.62 9.89 9 77809 64 79666506
Chronic kidney disease 34.53 9.89 142 77676 66012 79600558
Puncture site haematoma 34.39 9.89 11 77807 174 79666396
Swelling 33.74 9.89 104 77714 216607 79449963
Intestinal atony 33.68 9.89 8 77810 37 79666533
Hyponatraemia 33.56 9.89 292 77526 177556 79489014
Product dose omission issue 33.39 9.89 379 77439 247158 79419412
Off label use 33.30 9.89 655 77163 906560 78760010
Glycosylated haemoglobin increased 33.23 9.89 64 77754 19196 79647374
Intraocular haematoma 31.37 9.89 7 77811 23 79666547
Folliculitis 30.77 9.89 8 77810 55372 79611198
Suicide attempt 30.30 9.89 22 77796 82910 79583660
Blood thyroid stimulating hormone normal 29.83 9.89 9 77809 116 79666454
Hypersensitivity 29.19 9.89 144 77674 262095 79404475
Phaeochromocytoma malignant 29.12 9.89 8 77810 72 79666498
Full blood count decreased 29.10 9.89 74 77744 26745 79639825
Pemphigoid 29.05 9.89 53 77765 15262 79651308
Subdural haematoma 28.34 9.89 81 77737 31353 79635217
Febrile neutropenia 27.98 9.89 123 77695 230876 79435694
Hepatocellular injury 27.94 9.89 106 77712 47487 79619083
Infection 27.90 9.89 131 77687 241581 79424989
Cerebrovascular accident 27.77 9.89 252 77566 155040 79511530
Bezoar 27.41 9.89 22 77796 2666 79663904
Myositis 26.35 9.89 58 77760 19110 79647460
Blood loss anaemia 26.13 9.89 51 77767 15447 79651123
Diaphragmatic disorder 26.10 9.89 18 77800 1732 79664838
Cerebral haematoma 25.52 9.89 35 77783 7907 79658663
Angina pectoris 25.40 9.89 109 77709 51623 79614947
Shone complex 24.88 9.89 6 77812 30 79666540
Mitral valve hypoplasia 24.88 9.89 6 77812 30 79666540
Red blood cell sedimentation rate increased 24.84 9.89 7 77811 45935 79620635
Hyperkinetic heart syndrome 24.81 9.89 8 77810 130 79666440
Congenital aortic valve stenosis 24.72 9.89 6 77812 31 79666539
Aorta hypoplasia 24.56 9.89 6 77812 32 79666538
Immune-mediated myositis 24.47 9.89 23 77795 3444 79663126
Discomfort 24.34 9.89 54 77764 125563 79541007
Alopecia 24.07 9.89 130 77688 231225 79435345
Rheumatoid arthritis 24.05 9.89 113 77705 208357 79458213
Atrial fibrillation 24.03 9.89 297 77521 197589 79468981
Gait disturbance 23.74 9.89 308 77510 207198 79459372
Congenital heart valve disorder 23.42 9.89 6 77812 40 79666530
Musculoskeletal stiffness 23.17 9.89 90 77728 174918 79491652
Coma uraemic 23.16 9.89 6 77812 42 79666528
Therapy non-responder 22.97 9.89 34 77784 92271 79574299
Hepatitis cholestatic 22.65 9.89 45 77773 13807 79652763
Pericarditis fungal 22.39 9.89 8 77810 180 79666390
AST/ALT ratio abnormal 22.28 9.89 5 77813 17 79666553
Insulin autoimmune syndrome 22.09 9.89 10 77808 422 79666148
Pancreatitis acute 21.71 9.89 101 77717 49503 79617067
Hepatic enzyme increased 21.64 9.89 98 77720 182512 79484058
Femoral artery aneurysm 21.60 9.89 8 77810 200 79666370
Colitis microscopic 21.36 9.89 38 77780 10730 79655840
Heart transplant rejection 21.28 9.89 15 77803 1495 79665075
Blister 21.05 9.89 54 77764 119422 79547148
Ill-defined disorder 20.95 9.89 20 77798 65855 79600715
Pulseless electrical activity 20.79 9.89 44 77774 14116 79652454
Congenital aortic stenosis 20.73 9.89 5 77813 25 79666545
Congenital aortic anomaly 20.73 9.89 5 77813 25 79666545
Supravalvular aortic stenosis 20.73 9.89 5 77813 25 79666545
Exercise lack of 20.73 9.89 10 77808 488 79666082
Drug hypersensitivity 20.69 9.89 408 77410 298508 79368062
Coarctation of the aorta 20.59 9.89 6 77812 68 79666502
Haematoma 20.48 9.89 103 77715 52092 79614478
Toxic epidermal necrolysis 20.33 9.89 9 77809 44572 79621998
Cerebral infarction 19.99 9.89 93 77725 45583 79620987
Asthenia 19.84 9.89 646 77172 511043 79155527
Carnitine palmitoyltransferase deficiency 19.35 9.89 4 77814 8 79666562
Inflammation 19.25 9.89 39 77779 93714 79572856
Blood glucose increased 19.25 9.89 184 77634 114791 79551779
Acute interstitial pneumonitis 19.24 9.89 13 77805 1210 79665360
Melaena 19.07 9.89 113 77705 60777 79605793
Atrioventricular block first degree 18.55 9.89 39 77779 12452 79654118
Dysgeusia 18.48 9.89 107 77711 57070 79609500
Tachycardia 18.42 9.89 100 77718 177668 79488902
Impaired healing 18.40 9.89 36 77782 87619 79578951
Vertigo 18.40 9.89 123 77695 68959 79597611
Gastritis fungal 18.32 9.89 7 77811 191 79666379
Atrial hypertrophy 18.00 9.89 5 77813 47 79666523
Patent ductus arteriosus 17.99 9.89 6 77812 109 79666461
Transient ischaemic attack 17.95 9.89 100 77718 52595 79613975
Psoriasis 17.89 9.89 149 77669 89438 79577132
Eosinophilic pleural effusion 17.82 9.89 8 77810 331 79666239
Pancreatic steatosis 17.61 9.89 12 77806 1133 79665437
Toxic optic neuropathy 17.53 9.89 12 77806 1141 79665429
Metabolic acidosis 17.42 9.89 139 77679 82390 79584180
Haemorrhagic transformation stroke 17.37 9.89 17 77801 2675 79663895
Pseudolymphoma 17.05 9.89 12 77806 1193 79665377
Hyperlactacidaemia 17.00 9.89 24 77794 5571 79660999
Cardiac failure congestive 16.54 9.89 212 77606 142190 79524380
Acute respiratory failure 16.45 9.89 107 77711 59434 79607136
Intraventricular haemorrhage 16.41 9.89 22 77796 4865 79661705
Myotonic dystrophy 16.39 9.89 6 77812 145 79666425
Corneal dystrophy 16.25 9.89 7 77811 262 79666308
Hospice care 16.23 9.89 33 77785 10291 79656279
Sedation 16.21 9.89 16 77802 51879 79614691
Behaviour disorder 16.18 9.89 25 77793 6288 79660282
Laryngitis 16.11 9.89 43 77775 15996 79650574
Heart disease congenital 16.01 9.89 9 77809 603 79665967
Renal-limited thrombotic microangiopathy 15.91 9.89 6 77812 158 79666412
Tendon rupture 15.89 9.89 36 77782 12090 79654480
Myopathy toxic 15.69 9.89 11 77807 1087 79665483
Chest wall haematoma 15.68 9.89 8 77810 441 79666129
Intentional self-injury 15.67 9.89 6 77812 32413 79634157
Left ventricular failure 15.51 9.89 31 77787 9550 79657020
Anti factor VIII antibody positive 15.08 9.89 5 77813 89 79666481
Adenocarcinoma metastatic 15.02 9.89 6 77812 185 79666385
Sinus arrhythmia 14.90 9.89 14 77804 2096 79664474
Renal arteriosclerosis 14.84 9.89 7 77811 325 79666245
Cholestatic liver injury 14.72 9.89 21 77797 4920 79661650
Diabetic ketoacidosis 14.58 9.89 69 77749 34053 79632517
Post viral fatigue syndrome 14.50 9.89 7 77811 342 79666228
Injury 14.46 9.89 34 77784 77462 79589108
Bladder cyst 14.40 9.89 5 77813 103 79666467
Cerebral haemorrhage 14.36 9.89 101 77717 57572 79608998
Thrombotic stroke 14.31 9.89 9 77809 742 79665828
Anaemia 14.30 9.89 550 77268 444465 79222105
Cardiac murmur functional 14.27 9.89 4 77814 39 79666531
Electrocardiogram PR prolongation 14.15 9.89 12 77806 1571 79664999
Haematoma muscle 14.12 9.89 15 77803 2600 79663970
Low density lipoprotein increased 14.08 9.89 28 77790 8594 79657976
Pain 13.87 9.89 554 77264 703248 78963322
Fibromyalgia 13.87 9.89 26 77792 64314 79602256
Device expulsion 13.87 9.89 4 77814 25857 79640713
Loss of control of legs 13.80 9.89 13 77805 1952 79664618
Arteriovenous fistula 13.63 9.89 11 77807 1343 79665227
Mobility decreased 13.63 9.89 67 77751 122108 79544462
Eosinophilic pneumonia 13.57 9.89 21 77797 5289 79661281
Haemorrhage intracranial 13.49 9.89 56 77762 26137 79640433
Squamous cell carcinoma of skin 13.47 9.89 37 77781 13996 79652574
Subacute cutaneous lupus erythematosus 13.47 9.89 17 77801 3544 79663026
Blood glucose abnormal 13.44 9.89 31 77787 10535 79656035
Hypoparathyroidism 13.41 9.89 10 77808 1088 79665482
Axonal neuropathy 13.31 9.89 13 77805 2041 79664529
Oedema peripheral 13.22 9.89 331 77487 251957 79414613
Electrocardiogram abnormal 13.07 9.89 41 77777 16696 79649874
Gastrointestinal disorder 13.07 9.89 68 77750 122137 79544433
Restless legs syndrome 12.84 9.89 46 77772 20046 79646524
Akinesia 12.83 9.89 16 77802 3296 79663274
Hepatotoxicity 12.69 9.89 19 77799 51333 79615237
Mucosal inflammation 12.68 9.89 35 77783 75545 79591025
Fixed eruption 12.62 9.89 15 77803 2939 79663631
Glycosuria 12.62 9.89 13 77805 2175 79664395
Xerosis 12.58 9.89 10 77808 1196 79665374
Ligament rupture 12.51 9.89 16 77802 3378 79663192
Death 12.50 9.89 674 77144 565840 79100730
Bursitis 12.46 9.89 10 77808 35834 79630736
Hip arthroplasty 12.40 9.89 10 77808 35746 79630824
Mammogram abnormal 12.28 9.89 7 77811 482 79666088
Left ventricular hypertrophy 12.27 9.89 31 77787 11160 79655410
Speech disorder 12.21 9.89 93 77725 54352 79612218
Muscle haemorrhage 12.20 9.89 22 77796 6278 79660292
Cardiovascular disorder 12.15 9.89 42 77776 17983 79648587
Bacteriuria 12.11 9.89 10 77808 1261 79665309
Intensive care unit acquired weakness 12.09 9.89 12 77806 1921 79664649
Dry gangrene 12.06 9.89 9 77809 980 79665590
Electrocardiogram ST segment depression 12.06 9.89 19 77799 4859 79661711
Vessel puncture site bruise 11.98 9.89 7 77811 505 79666065
Muscle injury 11.97 9.89 18 77800 48543 79618027
Full blood count abnormal 11.97 9.89 74 77744 40400 79626170
Hypersensitivity vasculitis 11.89 9.89 23 77795 6920 79659650
Adenocarcinoma of appendix 11.87 9.89 4 77814 75 79666495
Loss of consciousness 11.86 9.89 230 77588 167713 79498857
Irritable bowel syndrome 11.86 9.89 27 77791 62214 79604356
General physical health deterioration 11.84 9.89 193 77625 275045 79391525
Pyuria 11.84 9.89 13 77805 2339 79664231
Hypokalaemia 11.84 9.89 202 77616 143838 79522732
Inappropriate antidiuretic hormone secretion 11.83 9.89 54 77764 26259 79640311
Mouth ulceration 11.81 9.89 12 77806 38382 79628188
Pericardial haemorrhage 11.80 9.89 18 77800 4477 79662093
Angular cheilitis 11.75 9.89 8 77810 754 79665816
Sopor 11.74 9.89 9 77809 33001 79633569
Decreased appetite 11.66 9.89 426 77392 341992 79324578
Uterine dilation and evacuation 11.58 9.89 3 77815 21 79666549
Product use issue 11.56 9.89 140 77678 209682 79456888
Essential hypertension 11.55 9.89 21 77797 6032 79660538
Meningitis fungal 11.46 9.89 5 77813 193 79666377
Therapy cessation 11.31 9.89 69 77749 37493 79629077
Splenic vein thrombosis 11.31 9.89 8 77810 802 79665768
Flushing 11.29 9.89 46 77772 88222 79578348
Gastric infection 11.26 9.89 16 77802 3737 79662833
Lower gastrointestinal haemorrhage 11.24 9.89 38 77780 16087 79650483
Renal failure 11.22 9.89 266 77552 200702 79465868
Therapeutic response decreased 11.18 9.89 31 77787 66822 79599748
Hepatitis fulminant 11.17 9.89 23 77795 7239 79659331
Hypoxic-ischaemic encephalopathy 11.13 9.89 24 77794 7796 79658774
Poor dental condition 11.13 9.89 7 77811 577 79665993
Intertrigo 11.12 9.89 8 77810 824 79665746
Drug resistance 11.04 9.89 15 77803 42198 79624372
Iron deficiency anaemia 11.03 9.89 52 77766 25620 79640950
Gastrointestinal haemorrhage 11.02 9.89 204 77614 147515 79519055
Loss of personal independence in daily activities 11.02 9.89 57 77761 102523 79564047
Sinusitis 10.94 9.89 130 77688 195371 79471199
Transaminases abnormal 10.86 9.89 8 77810 854 79665716
Head injury 10.85 9.89 68 77750 37301 79629269
Cutaneous lupus erythematosus 10.83 9.89 14 77804 2989 79663581
Foot deformity 10.76 9.89 5 77813 24069 79642501
Echocardiogram abnormal 10.67 9.89 12 77806 2216 79664354
Emotional distress 10.66 9.89 14 77804 39955 79626615
Ligament sprain 10.53 9.89 33 77785 13431 79653139
Hypovolaemic shock 10.46 9.89 31 77787 12245 79654325
Prostate cancer metastatic 10.46 9.89 16 77802 3991 79662579
Cerebral mass effect 10.41 9.89 11 77807 1895 79664675
Muscular weakness 10.32 9.89 217 77601 160512 79506058
Polymyalgia rheumatica 10.30 9.89 17 77801 4520 79662050
Dystonia 10.27 9.89 4 77814 21395 79645175
Cytokine release syndrome 10.24 9.89 12 77806 35986 79630584
Neurotoxicity 10.19 9.89 10 77808 32508 79634062
Tendon disorder 10.17 9.89 22 77796 7164 79659406
Scratch 10.05 9.89 24 77794 8339 79658231
Memory impairment 10.03 9.89 159 77659 111575 79554995
Blood folate decreased 9.97 9.89 9 77809 1280 79665290
Immunosuppressant drug level decreased 9.96 9.89 11 77807 1993 79664577
Product physical issue 9.93 9.89 16 77802 4169 79662401

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C10AA03 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, PLAIN
HMG CoA reductase inhibitors
ATC C10BA03 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Combinations of various lipid modifying agents
ATC C10BA11 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Combinations of various lipid modifying agents
ATC C10BA12 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Combinations of various lipid modifying agents
ATC C10BX02 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
FDA MoA N0000000121 Hydroxymethylglutaryl-CoA Reductase Inhibitors
FDA EPC N0000175589 HMG-CoA Reductase Inhibitor
CHEBI has role CHEBI:25212 metabolites
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:35821 anticholesteremic drugs
CHEBI has role CHEBI:78298 environmental contaminants
MeSH PA D000924 Anticholesteremic Agents
MeSH PA D000963 Antimetabolites
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D019161 Hydroxymethylglutaryl-CoA Reductase Inhibitors
MeSH PA D000960 Hypolipidemic Agents
MeSH PA D057847 Lipid Regulating Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypercholesterolemia indication 13644009
Arteriosclerotic vascular disease indication 72092001
Cerebrovascular accident indication 230690007
Familial hypercholesterolemia - heterozygous indication 238079002
Mixed hyperlipidemia indication 267434003
Hypertriglyceridemia indication 302870006
Familial type 3 hyperlipoproteinemia indication 398796005 DOID:3145
Primary Prevention of Coronary Heart Disease indication
Prevention of Transient Ischemic Attacks indication
Myocardial Infarction Prevention indication
Slow Progression of Coronary Artery Disease indication
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Constipation contraindication 14760008 DOID:2089
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Gastrointestinal ulcer contraindication 40845000
Low blood pressure contraindication 45007003
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Acute nephropathy contraindication 58574008
Diarrhea contraindication 62315008
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Factor II deficiency contraindication 73975000
Reye's syndrome contraindication 74351001 DOID:14525
Gastrointestinal hemorrhage contraindication 74474003
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Hemophilia contraindication 90935002
Kidney stone contraindication 95570007
Anemia due to enzyme deficiency contraindication 111577008
von Willebrand disorder contraindication 128105004 DOID:12531
Disorder of muscle contraindication 129565002 DOID:423
Liver function tests abnormal contraindication 166603001
Osteolysis contraindication 203522001
Hemorrhagic cerebral infarction contraindication 230706003
Disease of liver contraindication 235856003 DOID:409
Rhabdomyolysis contraindication 240131006
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Surgical procedure contraindication 387713003
Breastfeeding (mother) contraindication 413712001
Traumatic injury contraindication 417746004
Acute erosive gastritis contraindication 444926003
Uncontrolled Epilepsy contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.44 acidic
pKa2 13.74 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme INHIBITOR IC50 7.52 CHEMBL CHEMBL
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme IC50 8.38 CHEMBL
Solute carrier family 22 member 6 Transporter Ki 4.28 CHEMBL

External reference:

IDSource
4020548 VUID
N0000148255 NUI
D00893 KEGG_DRUG
81131-70-6 SECONDARY_CAS_RN
4020369 VANDF
4020548 VANDF
C0085542 UMLSCUI
CHEBI:63618 CHEBI
CHEMBL1144 ChEMBL_ID
CHEMBL690 ChEMBL_ID
D017035 MESH_DESCRIPTOR_UI
DB00175 DRUGBANK_ID
54687 PUBCHEM_CID
2953 IUPHAR_LIGAND_ID
6070 INN_ID
KXO2KT9N0G UNII
203144 RXNORM
1884 MMSL
5343 MMSL
81574 MMSL
d00348 MMSL
003606 NDDF
003607 NDDF
373566006 SNOMEDCT_US
96305006 SNOMEDCT_US
96306007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-0771 TABLET 10 mg ORAL ANDA 29 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-0771 TABLET 10 mg ORAL ANDA 29 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-0771 TABLET 10 mg ORAL ANDA 29 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-7201 TABLET 20 mg ORAL ANDA 29 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-7201 TABLET 20 mg ORAL ANDA 29 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-7201 TABLET 20 mg ORAL ANDA 29 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-7202 TABLET 40 mg ORAL ANDA 29 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-7202 TABLET 40 mg ORAL ANDA 29 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-7202 TABLET 40 mg ORAL ANDA 29 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-7270 TABLET 80 mg ORAL ANDA 29 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-7270 TABLET 80 mg ORAL ANDA 29 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-7270 TABLET 80 mg ORAL ANDA 29 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-7270 TABLET 80 mg ORAL ANDA 29 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0480-7270 TABLET 80 mg ORAL ANDA 25 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8029 TABLET 20 mg ORAL ANDA 28 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8029 TABLET 20 mg ORAL ANDA 28 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8030 TABLET 40 mg ORAL ANDA 28 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8030 TABLET 40 mg ORAL ANDA 28 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8158 TABLET 10 mg ORAL ANDA 28 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8158 TABLET 10 mg ORAL ANDA 28 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8159 TABLET 80 mg ORAL ANDA 29 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8410 TABLET 80 mg ORAL ANDA 28 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8410 TABLET 80 mg ORAL ANDA 28 sections
PRAVASTATIN SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 0781-5235 TABLET 80 mg ORAL ANDA 29 sections
PRAVASTATIN SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 0904-5891 TABLET 10 mg ORAL ANDA 28 sections
PRAVASTATIN SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 0904-5892 TABLET 20 mg ORAL ANDA 28 sections
PRAVASTATIN SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 0904-5893 TABLET 40 mg ORAL ANDA 28 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 10544-440 TABLET 10 mg ORAL ANDA 27 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 10544-505 TABLET 20 mg ORAL ANDA 27 sections
Pravastatin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 10544-507 TABLET 40 mg ORAL ANDA 27 sections