moxisylyte 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1855 54-32-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • thymoxyalcylamine
  • acetoxythymoxamine
  • moxisylyte hydrochloride
  • moxisylyte HCl
  • moxisylyte
  • moxilite
  • moxisylite
  • moxisylyt
  • thymoxamine
  • timoxamina
  • moxisylyte hydrochoride
  • carlytene
An alpha-adrenergic blocking agent that is used in Raynaud's disease. It is also used locally in the eye to reverse the mydriasis caused by phenylephrine and other sympathomimetic agents. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1312)
  • Molecular weight: 279.38
  • Formula: C16H25NO3
  • CLOGP: 3.29
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 38.77
  • ALOGS: -2.84
  • ROTB: 7

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK1,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK7,MAPK9,MAPKAPK2,MET,MTOR,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIK3CG,PIM2,PLK1,PLK2,PLK3,PLK4,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 60
kinase-selectivity-class BRAF,PDK4 2
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C04AX10 CARDIOVASCULAR SYSTEM
PERIPHERAL VASODILATORS
PERIPHERAL VASODILATORS
Other peripheral vasodilators
ATC G04BE06 GENITO URINARY SYSTEM AND SEX HORMONES
UROLOGICALS
UROLOGICALS
Drugs used in erectile dysfunction
MeSH PA D000317 Adrenergic alpha-Antagonists
MeSH PA D002317 Cardiovascular Agents
MeSH PA D008916 Miotics
MeSH PA D013565 Sympatholytics
MeSH PA D014665 Vasodilator Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists

Related Drugs by ATC class:

C04AX Other peripheral vasodilators 16 drugs
azapetinebencyclanebuflomedilbutalaminecetiedilcinepazideclazosentancyclandelatefasudilifenprodilnaftidrofurylphenoxybenzamine show all 16 →
G04BE Drugs used in erectile dysfunction 9 drugs
alprostadilapomorphineavanafilpapaverinesildenafiltadalafiludenafilvardenafilyohimbine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Raynaud's disease indication 195295006 DOID:10300
Impotence indication 397803000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.45 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
N0000166510 NUI
D08239 KEGG_DRUG
964-52-3 SECONDARY_CAS_RN
C0040108 UMLSCUI
CHEBI:94754 CHEBI
CHEMBL159226 ChEMBL_ID
CHEMBL1256739 ChEMBL_ID
DB09205 DRUGBANK_ID
D013948 MESH_DESCRIPTOR_UI
4260 PUBCHEM_CID
12306 IUPHAR_LIGAND_ID
1538 INN_ID
PW8QYA7KI0 UNII
10561 RXNORM
003768 NDDF
003769 NDDF
319442006 SNOMEDCT_US
395901000 SNOMEDCT_US
765351000 SNOMEDCT_US

Pharmaceutical products:

None