ifenprodil Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
vasodilators 1419 23210-56-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ifenprodil
  • ifenprodil tartrate
NMDA receptor antagonist; RN given refers to parent cpd without isomeric designation; structure
  • Molecular weight: 325.45
  • Formula: C21H27NO2
  • CLOGP: 3.96
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 43.70
  • ALOGS: -3.49
  • ROTB: 5

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 18.99 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 64.57 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 4.32 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C04AX28 CARDIOVASCULAR SYSTEM
PERIPHERAL VASODILATORS
PERIPHERAL VASODILATORS
Other peripheral vasodilators
MeSH PA D018663 Adrenergic Agents
MeSH PA D000317 Adrenergic alpha-Antagonists
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018691 Excitatory Amino Acid Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014665 Vasodilator Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.27 acidic
pKa2 9.1 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glutamate NMDA receptor; GRIN1/GRIN2B Ion channel Ki 8 CHEMBL
Histamine H1 receptor GPCR IC50 6 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor IC50 8.41 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 7 CHEMBL
Glutamate receptor ionotropic, NMDA 2B Ion channel IC50 7.70 CHEMBL
Glutamate receptor ionotropic, NMDA 1 Ion channel IC50 7.14 CHEMBL
Adrenergic receptor alpha-1 GPCR IC50 7 CHEMBL
Alpha-2A adrenergic receptor GPCR IC50 6.96 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 8.70 CHEMBL
5-hydroxytryptamine receptor 2A GPCR IC50 6.21 CHEMBL
3-beta-hydroxysteroid-delta(8),delta(7)-isomerase Unclassified Ki 8.57 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane other Ki 8.99 CHEMBL
5-hydroxytryptamine receptor 1A GPCR IC50 6.62 CHEMBL
Glutamate [NMDA] receptor subunit epsilon 2 Ion channel Ki 7.96 CHEMBL

External reference:

IDSource
C0063340 UMLSCUI
D01445 KEGG_DRUG
27403 RXNORM
005790 NDDF
16291000122106 SNOMEDCT_US
89CTB4XUF7 UNII
23210-58-4 SECONDARY_CAS_RN
CHEMBL305187 ChEMBL_ID
3236 INN_ID
DB08954 DRUGBANK_ID
CHEBI:31688 CHEBI
3689 PUBCHEM_CID
CHEMBL1256662 ChEMBL_ID
5472 IUPHAR_LIGAND_ID
C010739 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None