sildenafil ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
inhibitors of phosphodiesterase PDE5 with vasodilator action 2441 139755-83-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • mysildecard
  • sildenafil
  • sildenafil citrate
  • revatio
A PHOSPHODIESTERASE TYPE-5 INHIBITOR; VASODILATOR AGENT and UROLOGICAL AGENT that is used in the treatment of ERECTILE DYSFUNCTION and PRIMARY PULMONARY HYPERTENSION.
  • Molecular weight: 474.58
  • Formula: C22H30N6O4S
  • CLOGP: 2.20
  • LIPINSKI: 0
  • HAC: 10
  • HDO: 1
  • TPSA: 109.13
  • ALOGS: -3.01
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
50 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 3.50 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 7.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 3.52 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 38 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.36 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 9 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.04 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.20 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Sept. 13, 1998 EMA UPJOHN EESV
March 27, 1998 FDA PFIZER IRELAND

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pulmonary arterial hypertension 2813.19 13.13 1213 127515 21364 63338930
Dyspnoea 2379.69 13.13 4541 124187 656772 62703522
Fluid retention 1910.50 13.13 1299 127429 58387 63301907
Right ventricular failure 1857.81 13.13 836 127892 16352 63343942
Pulmonary hypertension 1652.33 13.13 995 127733 36128 63324166
Death 1545.08 13.13 2735 125993 371646 62988648
Pain in jaw 1459.12 13.13 975 127753 42521 63317773
Hypervolaemia 1032.98 13.13 670 128058 27743 63332551
Dyspnoea exertional 940.06 13.13 859 127869 59443 63300851
Drug ineffective 833.63 13.13 552 128176 1044213 62316081
Headache 729.97 13.13 2867 125861 630374 62729920
Catheter site erythema 705.42 13.13 281 128447 3995 63356299
Oxygen saturation decreased 621.68 13.13 830 127898 87755 63272539
Lung transplant 602.43 13.13 230 128498 2898 63357396
Flushing 567.86 13.13 730 127998 74357 63285937
Hospitalisation 567.83 13.13 778 127950 84303 63275991
Nasal congestion 558.32 13.13 677 128051 64983 63295311
Transfusion 533.72 13.13 351 128377 14866 63345428
Device related infection 513.66 13.13 406 128322 22986 63337308
Catheter site pruritus 474.35 13.13 174 128554 1946 63358348
Catheter management 457.17 13.13 186 128542 2801 63357493
Oedema 445.55 13.13 748 127980 96874 63263420
Catheter site pain 441.50 13.13 208 128520 4527 63355767
Infusion related reaction 438.34 13.13 13 128715 245508 63114786
Chest pain 420.87 13.13 1171 127557 214788 63145506
Hypoxia 420.45 13.13 561 128167 59231 63301063
Infusion site pain 410.03 13.13 311 128417 16558 63343736
Cardiac failure 405.39 13.13 682 128046 88460 63271834
Alopecia 399.20 13.13 97 128631 337439 63022855
Pulmonary arterial pressure increased 385.44 13.13 174 128554 3421 63356873
Catheter site discharge 366.17 13.13 142 128586 1871 63358423
Oedema peripheral 364.57 13.13 1023 127705 188488 63171806
Syncope 361.45 13.13 760 127968 116625 63243669
Pulmonary oedema 360.22 13.13 498 128230 54375 63305919
Contraindicated product administered 357.03 13.13 21 128707 217627 63142667
Catheterisation cardiac 338.64 13.13 172 128556 4431 63355863
Treatment failure 327.09 13.13 19 128709 199024 63161270
Cough 326.62 13.13 1315 127413 291428 63068866
Catheter site infection 325.17 13.13 171 128557 4743 63355551
Toxicity to various agents 318.99 13.13 58 128670 247192 63113102
Glossodynia 310.26 13.13 12 128716 178864 63181430
Rheumatoid arthritis 307.76 13.13 69 128659 253750 63106544
Oxygen consumption increased 305.90 13.13 152 128576 3732 63356562
Respiratory failure 302.55 13.13 650 128078 101208 63259086
Drug hypersensitivity 295.76 13.13 130 128598 310557 63049737
Pneumonia 295.00 13.13 1754 126974 455013 62905281
Rash 291.95 13.13 429 128299 560442 62799852
Arthropathy 288.34 13.13 62 128666 234730 63125564
Hypotension 282.29 13.13 1197 127531 271407 63088887
Cardiac failure congestive 276.96 13.13 592 128136 91841 63268453
Therapeutic product effect decreased 275.10 13.13 34 128694 193153 63167141
Joint swelling 274.73 13.13 162 128566 327504 63032790
Palpitations 272.21 13.13 663 128065 112107 63248187
Scleroderma 267.81 13.13 156 128572 5306 63354988
Neutropenia 266.61 13.13 24 128704 174981 63185313
Infusion site erythema 250.54 13.13 200 128528 11479 63348815
Central venous catheterisation 247.95 13.13 116 128612 2483 63357811
Catheter site swelling 242.87 13.13 97 128631 1388 63358906
Completed suicide 242.07 13.13 13 128715 145660 63214634
Dizziness 226.78 13.13 1569 127159 428356 62931938
Device alarm issue 226.38 13.13 93 128635 1437 63358857
Device leakage 225.53 13.13 154 128574 6942 63353352
Musculoskeletal stiffness 218.12 13.13 53 128675 184565 63175729
Catheter placement 218.07 13.13 102 128626 2182 63358112
Catheter site haemorrhage 214.39 13.13 112 128616 3063 63357231
Unevaluable event 213.61 13.13 378 128350 51008 63309286
Hepatic enzyme increased 211.66 13.13 73 128655 202255 63158039
Drug intolerance 208.89 13.13 191 128537 308470 63051824
Stomatitis 196.02 13.13 25 128703 138700 63221594
Hypersensitivity 193.46 13.13 185 128543 292500 63067794
Acute respiratory failure 191.22 13.13 289 128439 34196 63326098
Infusion site infection 189.69 13.13 86 128642 1708 63358586
Wound 186.83 13.13 50 128678 163213 63197081
Febrile neutropenia 186.57 13.13 14 128714 118435 63241859
Diarrhoea 184.21 13.13 2235 126493 713131 62647163
Cardiac disorder 183.74 13.13 352 128376 50464 63309830
Cardiac operation 182.65 13.13 102 128626 3196 63357098
Disease progression 179.08 13.13 602 128126 122156 63238138
Transplant evaluation 177.92 13.13 73 128655 1124 63359170
Pericarditis 175.89 13.13 28 128700 131551 63228743
Therapy change 170.00 13.13 122 128606 5959 63354335
Concomitant disease aggravated 166.13 13.13 142 128586 8970 63351324
Malaise 165.03 13.13 1421 127307 414533 62945761
Catheter site rash 163.93 13.13 61 128667 712 63359582
Discomfort 162.33 13.13 68 128660 167306 63192988
Drug interaction 161.93 13.13 136 128592 228995 63131299
Epistaxis 155.98 13.13 409 128319 72316 63287978
Dialysis 155.40 13.13 145 128583 10282 63350012
Pulmonary veno-occlusive disease 155.26 13.13 65 128663 1056 63359238
Maternal exposure during pregnancy 153.81 13.13 132 128596 219930 63140364
Device occlusion 153.13 13.13 124 128604 7263 63353031
Psoriatic arthropathy 152.53 13.13 8 128720 91512 63268782
Systemic lupus erythematosus 150.09 13.13 122 128606 208796 63151498
Helicobacter infection 148.91 13.13 10 128718 92775 63267519
Impaired healing 146.01 13.13 18 128710 102524 63257770
Blood cholesterol increased 145.59 13.13 12 128716 94020 63266274
Chest discomfort 145.35 13.13 522 128206 109447 63250847
Psoriasis 143.68 13.13 8 128720 86949 63273345
Ascites 143.40 13.13 279 128449 40449 63319845
Pericardial effusion 143.22 13.13 235 128493 29823 63330471
Catheter site irritation 141.28 13.13 50 128678 500 63359794
Pulmonary hypertensive crisis 139.06 13.13 44 128684 300 63359994
Hypertension 136.87 13.13 222 128506 279081 63081213
Urticaria 134.55 13.13 85 128643 165717 63194577
Dermatitis contact 133.96 13.13 137 128591 10871 63349423
Exercise tolerance decreased 132.79 13.13 101 128627 5396 63354898
Malignant neoplasm progression 131.34 13.13 9 128719 82112 63278182
Therapeutic product effect incomplete 130.93 13.13 45 128683 125011 63235283
Blister 128.69 13.13 51 128677 129763 63230531
Arthralgia 128.36 13.13 657 128071 569053 62791241
Off label use 128.28 13.13 822 127906 673640 62686654
Folliculitis 128.06 13.13 3 128725 70314 63289980
Vascular device infection 127.32 13.13 111 128617 7201 63353093
Infusion site discharge 126.52 13.13 49 128679 643 63359651
Mobility decreased 126.15 13.13 44 128684 121115 63239179
Dyspnoea at rest 126.03 13.13 87 128641 3992 63356302
Pruritus 122.57 13.13 353 128375 361100 62999194
Abdominal distension 122.07 13.13 420 128308 86195 63274099
Complication associated with device 121.85 13.13 161 128567 16817 63343477
Haemoptysis 121.52 13.13 213 128515 28513 63331781
Condition aggravated 120.28 13.13 1295 127433 400922 62959372
White blood cell count decreased 117.49 13.13 68 128660 139036 63221258
Muscle injury 114.55 13.13 4 128724 65341 63294953
Infusion site swelling 114.21 13.13 119 128609 9651 63350643
Right ventricular dysfunction 113.85 13.13 61 128667 1758 63358536
Presyncope 113.64 13.13 203 128525 27582 63332712
Paracentesis 110.53 13.13 49 128679 921 63359373
Confusional state 110.14 13.13 194 128534 236186 63124108
Product dose omission issue 109.22 13.13 831 127897 233482 63126812
Brain natriuretic peptide increased 109.10 13.13 88 128640 5125 63355169
Device dislocation 107.96 13.13 190 128538 25515 63334779
Heart rate increased 107.65 13.13 427 128301 93811 63266483
Injection site pain 107.43 13.13 65 128663 129735 63230559
Device infusion issue 107.36 13.13 61 128667 1977 63358317
N-terminal prohormone brain natriuretic peptide increased 106.68 13.13 62 128666 2099 63358195
Productive cough 105.74 13.13 325 128403 62883 63297411
Irritable bowel syndrome 104.72 13.13 20 128708 82392 63277902
Catheter site inflammation 102.58 13.13 45 128683 824 63359470
Product use in unapproved indication 101.85 13.13 128 128600 178952 63181342
Walking distance test abnormal 99.13 13.13 39 128689 535 63359759
Catheter site related reaction 98.51 13.13 45 128683 910 63359384
Drug abuse 97.86 13.13 15 128713 72503 63287791
Fibromyalgia 97.07 13.13 22 128706 80398 63279896
Anaphylactic reaction 95.58 13.13 11 128717 66089 63294205
Osteoarthritis 95.23 13.13 37 128691 95306 63264988
Heart transplant 94.35 13.13 37 128691 503 63359791
Myalgia 94.25 13.13 563 128165 145966 63214328
Cardiac pacemaker insertion 93.52 13.13 73 128655 4053 63356241
Type 2 diabetes mellitus 91.43 13.13 11 128717 63857 63296437
Blood pressure decreased 90.47 13.13 314 128414 64708 63295586
Influenza 89.64 13.13 447 128281 108275 63252019
Atrial flutter 88.28 13.13 104 128624 9668 63350626
Neutrophil count decreased 87.86 13.13 7 128721 56399 63303895
Sleep disorder due to general medical condition, insomnia type 85.65 13.13 5 128723 52212 63308082
Oxygen therapy 85.63 13.13 54 128674 2124 63358170
Cyanosis 85.57 13.13 136 128592 16799 63343495
Depression 85.54 13.13 168 128560 196324 63163970
Intentional product use issue 85.36 13.13 80 128648 127812 63232482
Emergency care 84.48 13.13 42 128686 1032 63359262
Electrocardiogram QT prolonged 83.40 13.13 11 128717 59519 63300775
Lower respiratory tract infection 82.30 13.13 88 128640 132219 63228075
Mucosal inflammation 81.81 13.13 3 128725 46925 63313369
Multiple sclerosis relapse 81.52 13.13 4 128724 48474 63311820
Intentional overdose 80.56 13.13 25 128703 74127 63286167
Cardiac ablation 79.72 13.13 45 128683 1440 63358854
Device related sepsis 79.15 13.13 66 128662 4028 63356266
Suicidal ideation 77.52 13.13 16 128712 62405 63297889
Blood pressure increased 77.27 13.13 131 128597 161931 63198363
Injection site reaction 76.96 13.13 13 128715 58511 63301783
Leukopenia 75.54 13.13 31 128697 77259 63283035
Catheter site vesicles 74.57 13.13 27 128701 290 63360004
Neuropathy peripheral 73.64 13.13 73 128655 113594 63246700
Cor pulmonale 73.51 13.13 48 128680 2006 63358288
Disease complication 73.22 13.13 57 128671 3152 63357142
Overdose 72.17 13.13 76 128652 115002 63245292
Injection site erythema 71.15 13.13 40 128688 83134 63277160
Suicide attempt 70.89 13.13 18 128710 60900 63299394
Pain 69.76 13.13 1070 127658 739558 62620736
Feeling abnormal 67.78 13.13 524 128204 147868 63212426
Ill-defined disorder 67.55 13.13 41 128687 81714 63278580
Abdominal cavity drainage 67.37 13.13 27 128701 390 63359904
Systemic scleroderma 67.36 13.13 35 128693 946 63359348
Right ventricular dilatation 66.66 13.13 39 128689 1337 63358957
Paraesthesia 65.91 13.13 137 128591 156829 63203465
Injection site bruising 65.84 13.13 5 128723 41905 63318389
Balloon atrial septostomy 65.64 13.13 18 128710 68 63360226
Mechanical ventilation 65.55 13.13 38 128690 1280 63359014
Atrial septal defect repair 65.16 13.13 23 128705 228 63360066
Nausea 65.13 13.13 2225 126503 852246 62508048
C-reactive protein increased 64.66 13.13 58 128670 94649 63265645
Respiration abnormal 64.21 13.13 72 128656 6345 63353949
Right ventricular systolic pressure increased 63.52 13.13 28 128700 519 63359775
Pleural effusion 62.39 13.13 362 128366 92848 63267446
Hypoaesthesia 61.81 13.13 158 128570 168235 63192059
Inappropriate schedule of product administration 61.53 13.13 72 128656 103893 63256401
Infusion site haemorrhage 61.34 13.13 63 128665 5023 63355271
Neoplasm progression 61.27 13.13 3 128725 36425 63323869
Chronic respiratory failure 61.26 13.13 42 128686 1905 63358389
Liver injury 61.24 13.13 23 128705 60497 63299797
Heart and lung transplant 60.62 13.13 18 128710 96 63360198
Chronic obstructive pulmonary disease 60.61 13.13 270 128458 62416 63297878
Infusion site induration 60.16 13.13 35 128693 1187 63359107
Terminal state 59.73 13.13 44 128684 2238 63358056
Pancytopenia 59.69 13.13 65 128663 96868 63263426
Red blood cell sedimentation rate increased 59.56 13.13 9 128719 43973 63316321
Coma 59.45 13.13 28 128700 64336 63295958
Cardioversion 59.17 13.13 35 128693 1225 63359069
Infusion site pruritus 59.17 13.13 67 128661 5968 63354326
Respiratory distress 59.04 13.13 177 128551 33774 63326520
Internal haemorrhage 58.74 13.13 62 128666 5103 63355191
Oxygen saturation abnormal 58.30 13.13 52 128676 3477 63356817
Gout 58.20 13.13 100 128628 13171 63347123
Pain in extremity 57.59 13.13 968 127760 330518 63029776
Catheter removal 57.54 13.13 24 128704 386 63359908
Injury 57.41 13.13 39 128689 73208 63287086
Thrombosis in device 57.39 13.13 48 128680 2942 63357352
Sedation 57.27 13.13 6 128722 38803 63321491
Catheter site warmth 56.42 13.13 20 128708 201 63360093
Depressed level of consciousness 55.82 13.13 28 128700 62050 63298244
Infusion site irritation 54.90 13.13 30 128698 900 63359394
Device connection issue 54.89 13.13 27 128701 648 63359646
Infusion site warmth 54.35 13.13 38 128690 1780 63358514
Tracheostomy 54.32 13.13 27 128701 663 63359631
Device malfunction 54.14 13.13 115 128613 17742 63342552
Lung disorder 53.44 13.13 259 128469 62002 63298292
Infusion site cellulitis 52.90 13.13 19 128709 199 63360095
Arthritis 52.26 13.13 97 128631 115824 63244470
Therapeutic response decreased 52.03 13.13 30 128698 61495 63298799
Medical device change 51.98 13.13 21 128707 310 63359984
Inflammation 51.96 13.13 54 128674 82219 63278075
Pulmonary arterial pressure abnormal 51.93 13.13 24 128704 499 63359795
Congestive hepatopathy 51.90 13.13 45 128683 2897 63357397
Stent placement 51.73 13.13 50 128678 3705 63356589
Concomitant disease progression 51.08 13.13 39 128689 2095 63358199
Right ventricular hypertrophy 50.92 13.13 26 128702 677 63359617
Rhinovirus infection 50.86 13.13 54 128674 4475 63355819
Deep vein thrombosis 50.70 13.13 57 128671 83743 63276551
Blood culture positive 50.61 13.13 55 128673 4680 63355614
Delirium 49.82 13.13 20 128708 50521 63309773
Therapy non-responder 49.63 13.13 293 128435 75608 63284686
Sinusitis 49.37 13.13 264 128464 226389 63133905
Bursitis 49.21 13.13 8 128720 37033 63323261
Wrong technique in product usage process 49.12 13.13 33 128695 62307 63297987
Dependence on oxygen therapy 48.84 13.13 22 128706 430 63359864
Liver transplant 48.63 13.13 39 128689 2252 63358042
Drug-induced liver injury 48.54 13.13 11 128717 40211 63320083
Drug reaction with eosinophilia and systemic symptoms 48 13.13 6 128722 33830 63326464
Cardiac failure acute 47.46 13.13 76 128652 9447 63350847
Finger amputation 47.37 13.13 23 128705 536 63359758
Device breakage 46.77 13.13 84 128644 11458 63348836
Blood potassium decreased 46.02 13.13 188 128540 41838 63318456
Thrombocytopenia 45.90 13.13 155 128573 151002 63209292
Rehabilitation therapy 45.88 13.13 33 128695 1617 63358677
Acute kidney injury 45.85 13.13 329 128399 263086 63097208
Aspiration pleural cavity 45.80 13.13 26 128702 841 63359453
Dizziness postural 45.47 13.13 65 128663 7311 63352983
Prescribed underdose 45.36 13.13 4 128724 29685 63330609
Infusion site abscess 45.11 13.13 17 128711 206 63360088
Biopsy liver 44.87 13.13 20 128708 381 63359913
Foot deformity 44.68 13.13 3 128725 27850 63332444
Catheterisation cardiac abnormal 44.53 13.13 17 128711 214 63360080
Peripheral swelling 43.76 13.13 770 127958 265172 63095122
Medication error 43.49 13.13 26 128702 52258 63308036
Blood pressure systolic increased 43.18 13.13 21 128707 47376 63312918
Renal disorder 43.07 13.13 156 128572 32818 63327476
Ventilation perfusion mismatch 42.96 13.13 21 128707 497 63359797
Atrial fibrillation 42.69 13.13 392 128336 116244 63244050
Pulmonary congestion 42.58 13.13 103 128625 17315 63342979
Transplant 42.35 13.13 24 128704 774 63359520
Device physical property issue 42.18 13.13 34 128694 1978 63358316
Asthma 42.09 13.13 126 128602 127435 63232859
Bone marrow failure 42.03 13.13 5 128723 29285 63331009
Right ventricular enlargement 41.98 13.13 18 128710 311 63359983
Injection site swelling 41.96 13.13 22 128706 47550 63312744
Incorrect route of product administration 41.14 13.13 4 128724 27448 63332846
Injection site pruritus 41.09 13.13 20 128708 45096 63315198
Acute right ventricular failure 40.94 13.13 15 128713 167 63360127
Joint range of motion decreased 40.91 13.13 8 128720 32420 63327874
Psychotic disorder 40.58 13.13 3 128725 25709 63334585
Injection site discharge 40.32 13.13 24 128704 850 63359444
Catheter site extravasation 40.19 13.13 18 128710 347 63359947
Gastrointestinal haemorrhage 40.06 13.13 292 128436 80884 63279410
Hypoglycaemia 39.56 13.13 38 128690 60027 63300267
Hyponatraemia 39.52 13.13 107 128621 111793 63248501
Blood creatine phosphokinase increased 39.48 13.13 7 128721 30423 63329871
Right-to-left cardiac shunt 39.31 13.13 16 128712 241 63360053
Lung assist device therapy 39.18 13.13 13 128715 105 63360189
Catheter site discolouration 38.96 13.13 13 128715 107 63360187
Oral herpes 38.55 13.13 4 128724 26070 63334224
Catheter site scab 38.38 13.13 15 128713 202 63360092
Orthopnoea 38.34 13.13 55 128673 6206 63354088
Catheter site nodule 38.32 13.13 11 128717 51 63360243
Left-to-right cardiac shunt 37.37 13.13 13 128715 123 63360171
Lymphocyte count decreased 37.06 13.13 8 128720 30249 63330045
Localised oedema 37.05 13.13 50 128678 5328 63354966
Myelosuppression 36.75 13.13 3 128725 23700 63336594
Sinus congestion 35.88 13.13 99 128629 18024 63342270
Night sweats 35.64 13.13 28 128700 48786 63311508
Drug dependence 35.58 13.13 4 128724 24479 63335815
Treatment noncompliance 35.50 13.13 160 128568 37165 63323129
Pulmonary vascular resistance abnormality 35.44 13.13 10 128718 43 63360251
Rales 35.33 13.13 79 128649 12618 63347676
Emotional distress 35.30 13.13 11 128717 32538 63327756
Basal cell carcinoma 35.11 13.13 7 128721 27984 63332310
Therapy cessation 34.74 13.13 138 128590 30319 63329975
Plasma cell myeloma 34.12 13.13 15 128713 35890 63324404
Retching 34.10 13.13 85 128643 14560 63345734
Adverse drug reaction 33.93 13.13 69 128659 79645 63280649
Cardiac arrest 33.84 13.13 311 128417 92234 63268060
Decreased appetite 33.79 13.13 705 128023 250347 63109947
Abdominal discomfort 33.77 13.13 453 128275 320432 63039862
Osteoporosis 33.60 13.13 40 128688 57298 63302996
Abortion spontaneous 33.30 13.13 28 128700 47167 63313127
Atrial tachycardia 33.23 13.13 42 128686 4198 63356096
Eczema 33.12 13.13 12 128716 32279 63328015
Infection 33.07 13.13 301 128427 228872 63131422
Cardiac output decreased 33.05 13.13 22 128706 950 63359344
Blood bilirubin increased 32.95 13.13 156 128572 36984 63323310
Generalised tonic-clonic seizure 32.94 13.13 9 128719 29007 63331287
Vascular resistance pulmonary increased 32.83 13.13 10 128718 59 63360235
Drug resistance 32.69 13.13 4 128724 22929 63337365
Pulmonary haemorrhage 32.67 13.13 55 128673 7126 63353168
Patent ductus arteriosus repair 32.54 13.13 8 128720 17 63360277
Hospice care 32.49 13.13 58 128670 7874 63352420
Swollen tongue 32.35 13.13 15 128713 34785 63325509
Bone disorder 32.24 13.13 3 128725 21323 63338971
Pulmonary arterial wedge pressure increased 32.19 13.13 15 128713 318 63359976
Liver function test abnormal 32.14 13.13 187 128541 47994 63312300
Application site pruritus 32.07 13.13 40 128688 3944 63356350
Paranasal sinus hypersecretion 32.00 13.13 39 128689 3756 63356538
Hyperglycaemia 31.87 13.13 23 128705 41844 63318450
Pulmonary arterial pressure 31.84 13.13 9 128719 39 63360255
Cognitive disorder 31.59 13.13 40 128688 55775 63304519
Central venous catheter removal 31.57 13.13 16 128712 410 63359884
Orthostatic hypotension 31.48 13.13 17 128711 36143 63324151
Blood culture negative 31.37 13.13 12 128716 152 63360142
Application site irritation 31.34 13.13 27 128701 1723 63358571
Pulmonary artery aneurysm 31.30 13.13 9 128719 42 63360252
Sopor 31.27 13.13 4 128724 22160 63338134
Disease recurrence 31.26 13.13 9 128719 28021 63332273
Product quality issue 31.02 13.13 17 128711 35848 63324446
Pulmonary artery dilatation 31.02 13.13 14 128714 275 63360019
Vascular resistance pulmonary decreased 30.90 13.13 10 128718 74 63360220
Dysentery 30.88 13.13 21 128707 940 63359354
Carbon dioxide increased 30.85 13.13 24 128704 1326 63358968
Multiple sclerosis 30.77 13.13 6 128722 24366 63335928
Diabetic ketoacidosis 30.69 13.13 3 128725 20502 63339792
Infusion site discolouration 30.60 13.13 20 128708 837 63359457
Joint stiffness 30.59 13.13 24 128704 41845 63318449
Systemic-pulmonary artery shunt 30.58 13.13 8 128720 24 63360270
Therapeutic embolisation 30.54 13.13 12 128716 164 63360130
Knee arthroplasty 30.52 13.13 39 128689 54167 63306127
Lactic acidosis 30.52 13.13 20 128708 38267 63322027
Balance disorder 30.35 13.13 80 128648 84342 63275952
Viral infection 30.34 13.13 148 128580 35515 63324779
Stevens-Johnson syndrome 29.75 13.13 7 128721 24943 63335351
Hypercholesterolaemia 29.74 13.13 4 128724 21330 63338964
Endotracheal intubation 29.31 13.13 31 128697 2557 63357737
Obesity 29.28 13.13 12 128716 29940 63330354
Haemorrhage 29.24 13.13 218 128510 60804 63299490
Sepsis 29.08 13.13 454 128274 152669 63207625
Sudden death 29.06 13.13 65 128663 10384 63349910
Rhinorrhoea 29.04 13.13 230 128498 65347 63294947
Drug eruption 28.87 13.13 11 128717 28683 63331611
Exposure during pregnancy 28.65 13.13 191 128537 155356 63204938
Hepatocellular injury 28.38 13.13 10 128718 27371 63332923
Sleep study 28.13 13.13 7 128721 16 63360278
Jugular vein distension 28.06 13.13 20 128708 966 63359328
Loss of personal independence in daily activities 28.02 13.13 102 128626 97188 63263106
Generalised oedema 28.00 13.13 83 128645 15735 63344559
Skin exfoliation 27.54 13.13 28 128700 43074 63317220
Blood alkaline phosphatase increased 27.52 13.13 165 128563 42802 63317492
Skin lesion 27.40 13.13 14 128714 30707 63329587
Hernia repair 27.37 13.13 24 128704 1569 63358725
Hepatic steatosis 27.37 13.13 12 128716 28757 63331537
Device issue 27.32 13.13 108 128620 23673 63336621
Sleep disorder 27.31 13.13 80 128648 81486 63278808
Dialysis related complication 27.31 13.13 9 128719 71 63360223
Product supply issue 27.30 13.13 25 128703 1730 63358564
Contusion 27.26 13.13 185 128543 149859 63210435
Aggression 27.23 13.13 7 128721 23491 63336803
Gastrostomy 27.22 13.13 17 128711 657 63359637
Swelling 27.09 13.13 394 128334 274984 63085310
Heart valve operation 27.01 13.13 11 128717 166 63360128
Metastases to bone 26.91 13.13 5 128723 21014 63339280
Accidental exposure to product 26.76 13.13 11 128717 27394 63332900
Device programming error 26.62 13.13 10 128718 120 63360174
Lymphopenia 26.61 13.13 3 128725 18324 63341970
Angioedema 26.50 13.13 35 128693 47930 63312364
Dyskinesia 26.50 13.13 16 128712 31986 63328308
Pulmonary vein stenosis 26.47 13.13 9 128719 79 63360215
Nocturnal dyspnoea 26.33 13.13 21 128707 1203 63359091
Colitis ulcerative 26.25 13.13 10 128718 26081 63334213
Hypocalcaemia 26.05 13.13 16 128712 31697 63328597
Anti factor VIII antibody test 26.02 13.13 5 128723 0 63360294
Coronary artery compression 26.02 13.13 5 128723 0 63360294
Infusion site oedema 25.97 13.13 18 128710 831 63359463
General physical health deterioration 25.90 13.13 272 128456 201130 63159164
Heart sounds 25.61 13.13 19 128709 977 63359317
Hallucination 25.47 13.13 45 128683 54772 63305522
Seizure 25.37 13.13 161 128567 132473 63227821
Ventricular septal defect repair 25.35 13.13 6 128722 10 63360284
Aphasia 25.29 13.13 18 128710 32982 63327312
Cardiogenic shock 25.28 13.13 87 128641 17845 63342449
Mouth ulceration 25.26 13.13 18 128710 32966 63327328
CREST syndrome 25.20 13.13 15 128713 531 63359763
Left ventricular failure 25.13 13.13 43 128685 5644 63354650
Cardiac flutter 25.11 13.13 36 128692 4060 63356234
Drug tolerance decreased 25.03 13.13 3 128725 17470 63342824
Staphylococcus test positive 25.00 13.13 35 128693 3861 63356433
Pericardial drainage 24.98 13.13 12 128716 273 63360021
Pulmonary pain 24.89 13.13 33 128695 3457 63356837
Drug withdrawal syndrome 24.85 13.13 12 128716 27182 63333112
Nasal dryness 24.83 13.13 38 128690 4543 63355751
Metabolic acidosis 24.78 13.13 33 128695 45036 63315258
Constipation 24.58 13.13 315 128413 224628 63135666
Cardiac failure chronic 24.44 13.13 37 128691 4381 63355913
Cardiomegaly 24.43 13.13 85 128643 17529 63342765
Acute myeloid leukaemia 24.42 13.13 3 128725 17144 63343150
Deafness 24.34 13.13 86 128642 17871 63342423
Head discomfort 24.33 13.13 71 128657 13344 63346950
Hyperlipidaemia 24.33 13.13 5 128723 19566 63340728
Aspartate aminotransferase increased 24.27 13.13 285 128443 89992 63270302
Dizziness exertional 24.19 13.13 13 128715 377 63359917
Vasodilatation 24.18 13.13 27 128701 2368 63357926
Prolonged expiration 24.00 13.13 19 128709 1077 63359217
Seasonal allergy 23.95 13.13 95 128633 20855 63339439
Application site odour 23.95 13.13 7 128721 35 63360259
Echocardiogram abnormal 23.89 13.13 21 128707 1377 63358917
Dysarthria 23.77 13.13 31 128697 42680 63317614
Hypothyroidism 23.66 13.13 31 128697 42601 63317693
Body temperature decreased 23.64 13.13 6 128722 20313 63339981
Pneumonitis 23.52 13.13 22 128706 35200 63325094
Blood pressure fluctuation 23.41 13.13 36 128692 46281 63314013
Respiratory syncytial virus infection 23.39 13.13 47 128681 6971 63353323
Exercise test abnormal 23.31 13.13 9 128719 117 63360177
Platelet count increased 23.14 13.13 4 128724 17707 63342587
Withdrawal syndrome 23.09 13.13 6 128722 19991 63340303
Tracheostomy tube removal 23.08 13.13 5 128723 4 63360290
Ammonia increased 22.98 13.13 37 128691 4619 63355675
Hypomagnesaemia 22.92 13.13 15 128713 28722 63331572
Head injury 22.81 13.13 113 128615 27283 63333011
Immunoglobulin G4 related disease 22.69 13.13 8 128720 79 63360215
Diagnostic procedure 22.65 13.13 9 128719 127 63360167
Carpal tunnel syndrome 22.64 13.13 7 128721 20810 63339484
Urinary retention 22.60 13.13 17 128711 30284 63330010
Pulmonary arterial pressure decreased 22.51 13.13 8 128720 81 63360213
Posterior reversible encephalopathy syndrome 22.48 13.13 4 128724 17341 63342953
Gastritis hypertrophic 22.48 13.13 7 128721 45 63360249
Drug level increased 22.40 13.13 9 128719 22727 63337567
Hypercalcaemia 22.30 13.13 15 128713 28307 63331987
Metastases to liver 22.26 13.13 10 128718 23629 63336665
Right atrial dilatation 22.24 13.13 15 128713 662 63359632
Hip arthroplasty 22.24 13.13 39 128689 47607 63312687
Rheumatoid nodule 22.14 13.13 4 128724 17151 63343143
Mood swings 22.00 13.13 5 128723 18243 63342051
Abnormal behaviour 21.91 13.13 8 128720 21418 63338876
Chronic right ventricular failure 21.81 13.13 6 128722 23 63360271
Epilepsy 21.76 13.13 14 128714 27051 63333243
Right atrial pressure increased 21.73 13.13 9 128719 142 63360152
Blood pressure abnormal 21.65 13.13 74 128654 15124 63345170
Infusion site inflammation 21.63 13.13 12 128716 371 63359923
Full blood count decreased 21.56 13.13 13 128715 26011 63334283
Brain natriuretic peptide abnormal 21.49 13.13 12 128716 376 63359918
Choking sensation 21.44 13.13 31 128697 3523 63356771
Oxygen consumption 21.37 13.13 8 128720 95 63360199
Diet noncompliance 21.34 13.13 12 128716 381 63359913
Blood iron decreased 21.26 13.13 72 128656 14649 63345645
Cor pulmonale chronic 21.25 13.13 10 128718 217 63360077
Upper respiratory tract infection 21.17 13.13 257 128471 81790 63278504
Ear tube insertion 21.15 13.13 8 128720 98 63360196
Tubulointerstitial nephritis 21.10 13.13 7 128721 19896 63340398
Tracheostomy malfunction 21.05 13.13 7 128721 57 63360237
Nodular regenerative hyperplasia 21.04 13.13 13 128715 493 63359801
Infusion site rash 21.03 13.13 23 128705 1971 63358323
Increased ventricular preload 20.81 13.13 4 128724 0 63360294
Large intestinal polypectomy 20.80 13.13 10 128718 228 63360066
Injection site mass 20.78 13.13 6 128722 18650 63341644
Pulmonary thrombosis 20.78 13.13 51 128677 8651 63351643
Body temperature increased 20.69 13.13 27 128701 37165 63323129
Osteonecrosis 20.68 13.13 12 128716 24518 63335776
Impaired work ability 20.64 13.13 5 128723 17470 63342824
Musculoskeletal disorder 20.62 13.13 8 128720 20636 63339658
Catheter culture positive 20.61 13.13 9 128719 163 63360131
Tenderness 20.57 13.13 10 128718 22568 63337726
Catheter site dryness 20.53 13.13 6 128722 30 63360264
Renal failure 20.52 13.13 344 128384 117308 63242986
Premature delivery 20.50 13.13 118 128610 30163 63330131
Product storage error 20.39 13.13 3 128725 14953 63345341
Catheter site hypersensitivity 20.38 13.13 8 128720 109 63360185
Dry eye 20.29 13.13 32 128696 40729 63319565
Wound infection 20.25 13.13 9 128719 21401 63338893
Life support 20.14 13.13 10 128718 245 63360049
Throat irritation 20.07 13.13 138 128590 37509 63322785
Pulseless electrical activity 20.04 13.13 46 128682 7475 63352819
Hepatitis 20.03 13.13 31 128697 39757 63320537
Hyperkalaemia 19.76 13.13 51 128677 54152 63306142
Agitation 19.72 13.13 59 128669 59698 63300596
Respiratory tract haemorrhage 19.69 13.13 12 128716 444 63359850
Sinus bradycardia 19.65 13.13 3 128725 14548 63345746
Cardiac index decreased 19.60 13.13 7 128721 72 63360222
Intervertebral disc degeneration 19.60 13.13 4 128724 15728 63344566
Sinus disorder 19.54 13.13 100 128628 24453 63335841
Cytomegalovirus infection 19.52 13.13 9 128719 20943 63339351
Gastrointestinal tube insertion 19.40 13.13 17 128711 1110 63359184
Myelodysplastic syndrome 19.39 13.13 5 128723 16749 63343545
Critical illness 19.39 13.13 9 128719 189 63360105
Eosinophilia 19.37 13.13 11 128717 22745 63337549
Pancreatitis acute 19.31 13.13 16 128712 27150 63333144
Injection site rash 19.27 13.13 7 128721 18802 63341492
Lip dry 19.13 13.13 4 128724 15466 63344828
Catheter site cellulitis 19.12 13.13 10 128718 274 63360020
Altered state of consciousness 19.02 13.13 14 128714 25216 63335078
Colitis 19.00 13.13 44 128684 48484 63311810
Tendonitis 18.95 13.13 8 128720 19607 63340687
Cyst 18.83 13.13 3 128725 14096 63346198
Intentional product misuse 18.80 13.13 62 128666 60855 63299439
Pulmonary embolism 18.72 13.13 149 128579 116535 63243759
Status epilepticus 18.71 13.13 4 128724 15229 63345065
Nasopharyngitis 18.66 13.13 660 128068 253597 63106697
Ataxia 18.65 13.13 4 128724 15191 63345103
Sudden visual loss 18.64 13.13 5 128723 17 63360277
Intra-abdominal haemorrhage 18.63 13.13 24 128704 2445 63357849
Choking 18.61 13.13 53 128675 9826 63350468
Cavopulmonary anastomosis 18.58 13.13 4 128724 3 63360291
Arteriovenous malformation 18.53 13.13 18 128710 1342 63358952
Somnolence 18.50 13.13 253 128475 178432 63181862
Gastric antral vascular ectasia 18.50 13.13 13 128715 614 63359680
Cardiac failure high output 18.45 13.13 10 128718 295 63359999
Spinal osteoarthritis 18.41 13.13 5 128723 16181 63344113
COVID-19 18.35 13.13 144 128584 112959 63247335
Facial pain 18.30 13.13 55 128673 10506 63349788
Protein-losing gastroenteropathy 18.30 13.13 9 128719 216 63360078
Weight decreased 18.26 13.13 710 128018 276088 63084206
Optic ischaemic neuropathy 18.22 13.13 17 128711 1205 63359089
Proteinuria 18.19 13.13 8 128720 19137 63341157
Skin operation 18.01 13.13 5 128723 20 63360274
Macular degeneration 17.77 13.13 14 128714 24362 63335932
Bone density decreased 17.62 13.13 4 128724 14608 63345686
Acne 17.46 13.13 13 128715 23280 63337014
Catheter site induration 17.42 13.13 6 128722 55 63360239
Herpes zoster 17.40 13.13 97 128631 82365 63277929
Hypokalaemia 17.38 13.13 131 128597 103673 63256621
Intra-abdominal fluid collection 17.37 13.13 23 128705 2406 63357888
Pulmonary artery therapeutic procedure 17.27 13.13 5 128723 24 63360270
Pulmonary valve replacement 17.16 13.13 4 128724 6 63360288
Blood calcium decreased 17.11 13.13 17 128711 26434 63333860
Metastases to central nervous system 17.03 13.13 3 128725 13102 63347192
Gastrointestinal disorder 16.96 13.13 177 128551 131062 63229232
Cardiopulmonary failure 16.88 13.13 28 128700 3584 63356710
Chronic hepatic failure 16.85 13.13 12 128716 579 63359715
Heart valve replacement 16.81 13.13 12 128716 581 63359713
Cholestasis 16.75 13.13 21 128707 29413 63330881
Cardiorenal syndrome 16.70 13.13 14 128714 861 63359433
Oesophagogastric fundoplasty 16.65 13.13 7 128721 115 63360179
Peritonitis 16.56 13.13 7 128721 17147 63343147
Supraventricular tachycardia 16.55 13.13 65 128663 14206 63346088
Device difficult to use 16.48 13.13 3 128725 12793 63347501
Ear discomfort 16.46 13.13 44 128684 7862 63352432
Mineral supplementation 16.43 13.13 13 128715 736 63359558
Metastases to lung 16.39 13.13 3 128725 12747 63347547
Angioplasty 16.35 13.13 17 128711 1375 63358919
Ischaemic stroke 16.29 13.13 8 128720 17949 63342345
Loss of consciousness 16.29 13.13 333 128395 117788 63242506
Chemotherapy 16.28 13.13 18 128710 1561 63358733
Gait inability 16.27 13.13 54 128674 52905 63307389
Purulent discharge 16.27 13.13 32 128696 4674 63355620
Suture related complication 16.26 13.13 8 128720 192 63360102
Bacteraemia 16.22 13.13 74 128654 17274 63343020
Dysphagia 16.19 13.13 109 128619 88476 63271818
Coordination abnormal 16.16 13.13 4 128724 13769 63346525
Catheter site urticaria 16.07 13.13 5 128723 32 63360262
Biopsy lymph gland 16.07 13.13 5 128723 32 63360262
Intentional medical device removal by patient 16.07 13.13 7 128721 126 63360168
Investigation 16.04 13.13 18 128710 1587 63358707
Gait disturbance 16.00 13.13 268 128460 182910 63177384
Biopsy lung 15.97 13.13 8 128720 200 63360094
Radiotherapy 15.96 13.13 10 128718 389 63359905
Cerebral infarction 15.86 13.13 15 128713 23878 63336416
Hypothermia 15.82 13.13 4 128724 13577 63346717
Speech disorder 15.77 13.13 37 128691 40592 63319702
Product prescribing error 15.77 13.13 18 128710 26271 63334023
Biopsy 15.72 13.13 11 128717 516 63359778
Blood test abnormal 15.71 13.13 6 128722 15623 63344671
Breast tumour excision 15.61 13.13 3 128725 0 63360294
Biopsy kidney 15.58 13.13 7 128721 136 63360158
Vascular device occlusion 15.58 13.13 7 128721 136 63360158
Clostridium difficile infection 15.54 13.13 109 128619 29813 63330481
Portopulmonary hypertension 15.53 13.13 7 128721 137 63360157
Bradycardia 15.53 13.13 86 128642 73141 63287153
Hallucination, visual 15.49 13.13 10 128718 19288 63341006
Disability 15.43 13.13 9 128719 18338 63341956
Nodule 15.42 13.13 12 128716 21014 63339280
Osteomyelitis 15.41 13.13 18 128710 26002 63334292
Inferior vena cava dilatation 15.34 13.13 6 128722 81 63360213
Nightmare 15.33 13.13 10 128718 19184 63341110
Sickle cell anaemia 15.24 13.13 11 128717 542 63359752
Haemodynamic test abnormal 15.22 13.13 5 128723 39 63360255
Fistula repair 15.22 13.13 5 128723 39 63360255
Bronchopulmonary dysplasia 15.21 13.13 10 128718 423 63359871
Cardiospasm 15.12 13.13 19 128709 1888 63358406
Hip fracture 15.10 13.13 107 128621 29367 63330927
Delusion 15.08 13.13 3 128725 12014 63348280
Obstructive airways disorder 14.95 13.13 12 128716 20687 63339607
Fall 14.94 13.13 954 127774 391380 62968914
Live birth 14.89 13.13 18 128710 25612 63334682
Diabetes mellitus inadequate control 14.88 13.13 6 128722 15120 63345174
Rash erythematous 14.74 13.13 41 128687 42469 63317825
Toxic skin eruption 14.62 13.13 4 128724 12881 63347413
Muscular weakness 14.62 13.13 168 128560 122185 63238109
Pulmonary arteriovenous fistula 14.61 13.13 4 128724 15 63360279
Atrial pressure increased 14.61 13.13 4 128724 15 63360279
Spinal stenosis 14.56 13.13 6 128722 14919 63345375
Vitamin D deficiency 14.53 13.13 5 128723 13887 63346407
Hallucination, auditory 14.52 13.13 4 128724 12820 63347474
Vomiting 14.51 13.13 1320 127408 558297 62801997
Chest tube insertion 14.50 13.13 5 128723 46 63360248
Application site erythema 14.49 13.13 31 128697 4804 63355490
Carbon dioxide abnormal 14.46 13.13 7 128721 162 63360132
Breast cancer 14.41 13.13 50 128678 48333 63311961
Implantable defibrillator insertion 14.40 13.13 10 128718 463 63359831
N-terminal prohormone brain natriuretic peptide abnormal 14.40 13.13 5 128723 47 63360247
Metapneumovirus infection 14.39 13.13 14 128714 1046 63359248
Retinopathy of prematurity 14.36 13.13 9 128719 350 63359944
Eye irritation 14.35 13.13 14 128714 21957 63338337
Encephalopathy 14.34 13.13 36 128692 38584 63321710
Pneumonia bacterial 14.29 13.13 47 128681 9418 63350876
Wrong dose 14.28 13.13 15 128713 1228 63359066
Dilatation ventricular 14.28 13.13 21 128707 2424 63357870
Blood pressure diastolic decreased 14.22 13.13 15 128713 22691 63337603
Injection site haemorrhage 14.20 13.13 17 128711 24297 63335997
Pneumothorax 14.20 13.13 68 128660 16193 63344101
Nephrolithiasis 14.18 13.13 41 128687 41943 63318351
Foetal exposure during pregnancy 14.17 13.13 27 128701 31935 63328359
Dysgeusia 14.10 13.13 48 128680 46662 63313632
Catheter site bruise 14.07 13.13 10 128718 481 63359813
Infusion site injury 14.04 13.13 5 128723 51 63360243
Neurodevelopmental disorder 14.01 13.13 7 128721 174 63360120
Decreased activity 14.00 13.13 36 128692 6284 63354010
Food allergy 13.99 13.13 3 128725 11398 63348896
Abdominal pain 13.99 13.13 471 128257 292985 63067309
Rash pruritic 13.93 13.13 68 128660 59731 63300563
Blood glucose increased 13.88 13.13 106 128622 83650 63276644
Bronchitis 13.71 13.13 341 128387 124594 63235700
Cardiac procedure complication 13.68 13.13 7 128721 183 63360111
Iron deficiency anaemia 13.64 13.13 78 128650 19891 63340403
Intracardiac pressure increased 13.62 13.13 5 128723 56 63360238
Jejunostomy 13.54 13.13 3 128725 3 63360291
Skin irritation 13.50 13.13 47 128681 9694 63350600
Joint effusion 13.48 13.13 9 128719 17051 63343243
Unevaluable investigation 13.46 13.13 5 128723 58 63360236
Injection site warmth 13.44 13.13 7 128721 15188 63345106
Coronary arterial stent insertion 13.31 13.13 22 128706 2807 63357487
Product substitution issue 13.24 13.13 8 128720 15988 63344306
Femur fracture 13.23 13.13 42 128686 41714 63318580
Cataract 13.22 13.13 65 128663 56988 63303306
Infusion site vesicles 13.20 13.13 10 128718 531 63359763
Infusion site reaction 13.14 13.13 25 128703 3562 63356732

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pulmonary arterial hypertension 900.20 11.07 432 82787 8307 34865405
Right ventricular failure 669.05 11.07 354 82865 8430 34865282
Pulmonary hypertension 658.38 11.07 480 82739 20444 34853268
Fluid retention 597.08 11.07 502 82717 26385 34847327
Dyspnoea 473.57 11.07 1957 81262 374825 34498887
Headache 435.76 11.07 1252 81967 199383 34674329
Pain in jaw 418.83 11.07 303 82916 12737 34860975
Optic ischaemic neuropathy 373.41 11.07 152 83067 1930 34871782
Death 344.32 11.07 1856 81363 396193 34477519
Cyanopsia 315.89 11.07 77 83142 121 34873591
Flushing 265.90 11.07 356 82863 32064 34841648
Hypervolaemia 254.99 11.07 273 82946 19436 34854276
Erection increased 241.30 11.07 77 83142 450 34873262
Nasal congestion 218.50 11.07 272 82947 22785 34850927
Neutropenia 215.45 11.07 54 83165 156724 34716988
Febrile neutropenia 208.80 11.07 37 83182 136812 34736900
Lung transplant 202.10 11.07 98 83121 1926 34871786
Oxygen saturation decreased 163.83 11.07 382 82837 53436 34820276
Catheter management 161.31 11.07 67 83152 898 34872814
Malignant neoplasm progression 160.69 11.07 13 83206 88033 34785679
Drug ineffective 157.16 11.07 1717 81502 455034 34418678
Dyspnoea exertional 151.69 11.07 325 82894 42954 34830758
Infusion site pain 143.40 11.07 98 83121 3753 34869959
Catheterisation cardiac 141.61 11.07 85 83134 2592 34871120
Catheter site erythema 137.28 11.07 67 83152 1336 34872376
Transfusion 129.18 11.07 129 83090 8456 34865256
Thrombocytopenia 123.55 11.07 114 83105 156133 34717579
Blindness unilateral 122.31 11.07 95 83124 4447 34869265
Oxygen consumption increased 112.38 11.07 58 83161 1308 34872404
Suspected counterfeit product 109.66 11.07 37 83182 264 34873448
Erectile dysfunction 109.53 11.07 185 83034 20452 34853260
Visual field defect 106.26 11.07 87 83132 4396 34869316
Pulmonary arterial pressure increased 104.90 11.07 54 83165 1211 34872501
Hospitalisation 103.12 11.07 334 82885 56568 34817144
Catheter placement 102.51 11.07 46 83173 752 34872960
Priapism 102.09 11.07 89 83130 4905 34868807
Syncope 97.71 11.07 454 82765 90997 34782715
Oedema 97.32 11.07 284 82935 45457 34828255
Visual impairment 96.97 11.07 243 82976 35559 34838153
Leukopenia 95.77 11.07 17 83202 62839 34810873
Vision blurred 92.68 11.07 280 82939 45683 34828029
Cardiac operation 90.28 11.07 68 83151 3039 34870673
Hypoxia 88 11.07 310 82909 54785 34818927
Acute kidney injury 87.04 11.07 402 82817 304586 34569126
Catheter site pruritus 86.67 11.07 32 83187 306 34873406
Prescription drug used without a prescription 85.42 11.07 57 83162 2097 34871615
Toxicity to various agents 84.06 11.07 224 82995 200138 34673574
Infusion site erythema 82.64 11.07 57 83162 2216 34871496
Cardiac failure 81.12 11.07 430 82789 90818 34782894
Pulmonary hypertensive crisis 78.07 11.07 25 83194 148 34873564
Device related infection 75.38 11.07 142 83077 17095 34856617
Oedema peripheral 74.85 11.07 515 82704 119297 34754415
Catheter site discharge 72.96 11.07 34 83185 609 34873103
Dizziness 70.28 11.07 812 82407 217709 34656003
Mucosal inflammation 69.61 11.07 6 83213 38616 34835096
Chromatopsia 69.45 11.07 27 83192 301 34873411
Peyronie's disease 68.62 11.07 18 83201 44 34873668
Pyrexia 67.58 11.07 490 82729 332523 34541189
Catheter site pain 64.41 11.07 40 83179 1298 34872414
Off label use 63.95 11.07 665 82554 418859 34454853
Palpitations 63.84 11.07 225 82994 39761 34833951
Device alarm issue 63.75 11.07 31 83188 613 34873099
Condition aggravated 63.48 11.07 718 82501 191478 34682234
Central venous catheterisation 61.86 11.07 39 83180 1300 34872412
Product use in unapproved indication 61.78 11.07 116 83103 117383 34756329
Ventilation perfusion mismatch 61.39 11.07 18 83201 75 34873637
Hyponatraemia 61.05 11.07 64 83155 82627 34791085
Neutrophil count decreased 60.41 11.07 23 83196 51081 34822631
Pancytopenia 59.32 11.07 84 83135 95073 34778639
White blood cell count decreased 58.76 11.07 85 83134 95360 34778352
General physical health deterioration 58.72 11.07 137 83082 128132 34745580
Infusion site haemorrhage 58.67 11.07 34 83185 970 34872742
Heart transplant 57.95 11.07 33 83186 910 34872802
Retinal vein occlusion 57.58 11.07 41 83178 1678 34872034
Pain in extremity 57.44 11.07 505 82714 126008 34747704
Complication associated with device 57.10 11.07 71 83148 5935 34867777
Chest pain 57.04 11.07 505 82714 126257 34747455
Anaemia 56.60 11.07 325 82894 233010 34640702
Thrombosis corpora cavernosa 55.47 11.07 11 83208 0 34873712
Counterfeit product administered 54 11.07 19 83200 156 34873556
Cardiac disorder 53.51 11.07 224 82995 42902 34830810
Self-medication 52.90 11.07 47 83172 2656 34871056
Catheter site infection 52.51 11.07 46 83173 2551 34871161
Catheter site irritation 52.34 11.07 17 83202 106 34873606
Transplant evaluation 52.03 11.07 25 83194 481 34873231
Blindness 50.70 11.07 111 83108 14875 34858837
Infusion site infection 50.27 11.07 24 83195 455 34873257
Catheter site rash 49.68 11.07 19 83200 202 34873510
Infusion related reaction 49.07 11.07 33 83186 53024 34820688
Pulmonary veno-occlusive disease 47.75 11.07 24 83195 511 34873201
Dyschromatopsia 47.46 11.07 22 83197 389 34873323
Device dislocation 47.22 11.07 66 83153 6183 34867529
Platelet count decreased 47.05 11.07 138 83081 119579 34754133
Bone marrow failure 46.58 11.07 7 83212 29246 34844466
Transient global amnesia 46.21 11.07 21 83198 354 34873358
Deafness unilateral 45.91 11.07 38 83181 1949 34871763
Electrocardiogram QT prolonged 45.85 11.07 20 83199 40932 34832780
Retinal artery occlusion 45.55 11.07 37 83182 1848 34871864
Liver transplant 45.54 11.07 42 83177 2492 34871220
Pre-existing condition improved 44.73 11.07 42 83177 2550 34871162
Cardiac failure congestive 43.97 11.07 344 82875 82926 34790786
Deafness 43.41 11.07 88 83131 11177 34862535
C-reactive protein increased 43.25 11.07 39 83180 54059 34819653
Peripheral swelling 42.53 11.07 320 82899 76221 34797491
Catheter site swelling 42.53 11.07 20 83199 366 34873346
Cytomegalovirus infection 42.20 11.07 6 83213 26129 34847583
Heart and lung transplant 41.94 11.07 13 83206 68 34873644
Renal impairment 40.83 11.07 104 83115 94409 34779303
Therapy change 40.44 11.07 43 83176 3034 34870678
Loss of visual contrast sensitivity 40.34 11.07 8 83211 0 34873712
Product counterfeit 40.30 11.07 15 83204 147 34873565
Blindness transient 40.21 11.07 37 83182 2189 34871523
Colitis 39.85 11.07 20 83199 37730 34835982
Concomitant disease aggravated 39.83 11.07 58 83161 5643 34868069
Pulmonary oedema 39.50 11.07 220 82999 47309 34826403
Treatment failure 39.36 11.07 32 83187 46665 34827047
Myalgia 39.31 11.07 338 82881 83772 34789940
Spontaneous penile erection 38.89 11.07 16 83203 209 34873503
Dermatitis contact 38.76 11.07 45 83174 3501 34870211
Stomatitis 38.57 11.07 27 83192 42487 34831225
Visual brightness 37.96 11.07 10 83209 25 34873687
Completed suicide 37.95 11.07 114 83105 98054 34775658
Hepatic function abnormal 37.89 11.07 30 83189 44333 34829379
Device occlusion 37.85 11.07 61 83158 6484 34867228
Penile curvature 37.57 11.07 13 83206 101 34873611
Pruritus 36.98 11.07 193 83026 141788 34731924
Oxygen therapy 36.23 11.07 24 83195 872 34872840
Ventricular assist device insertion 35.88 11.07 9 83210 17 34873695
Malaise 35.69 11.07 631 82588 185194 34688518
Feeling abnormal 35.48 11.07 265 82954 62970 34810742
Drug resistance 35.41 11.07 9 83210 25918 34847794
Biopsy liver 35.36 11.07 16 83203 267 34873445
Walking distance test abnormal 35.02 11.07 14 83205 169 34873543
Rash maculo-papular 34.98 11.07 12 83207 28439 34845273
Retinal vascular disorder 34.58 11.07 14 83205 175 34873537
Catheter site haemorrhage 34.53 11.07 34 83185 2190 34871522
Spinal cord infarction 34.31 11.07 16 83203 287 34873425
Biopsy lung 34.26 11.07 13 83206 135 34873577
Infusion site discharge 34.16 11.07 12 83207 98 34873614
Rheumatoid arthritis 33.75 11.07 25 83194 38213 34835499
Foetal exposure during pregnancy 33.51 11.07 25 83194 38076 34835636
Colour blindness 33.49 11.07 15 83204 244 34873468
Viral infection 33.30 11.07 105 83114 17518 34856194
Hypotension 33.24 11.07 725 82494 220924 34652788
Visual acuity reduced 33.11 11.07 99 83120 16050 34857662
Vascular resistance pulmonary increased 32.97 11.07 9 83210 27 34873685
Vascular device infection 32.82 11.07 45 83174 4140 34869572
Pneumonitis 32.79 11.07 20 83199 33858 34839854
Eosinophilia 32.34 11.07 11 83208 26211 34847501
Exercise tolerance decreased 32.20 11.07 50 83169 5148 34868564
Fracture of penis 31.64 11.07 14 83205 221 34873491
Paracentesis 31.43 11.07 17 83202 423 34873289
Drug reaction with eosinophilia and systemic symptoms 31.24 11.07 20 83199 32992 34840720
Confusional state 31.15 11.07 208 83011 143952 34729760
Cytokine release syndrome 31.13 11.07 8 83211 22869 34850843
Septic shock 31.05 11.07 79 83140 71755 34801957
Pulmonary vein stenosis 30.99 11.07 9 83210 36 34873676
Metabolic acidosis 30.90 11.07 35 83184 43645 34830067
Cyanosis 30.81 11.07 83 83136 12681 34861031
N-terminal prohormone brain natriuretic peptide increased 30.59 11.07 35 83184 2680 34871032
Painful erection 30.54 11.07 14 83205 241 34873471
Tracheostomy 30.45 11.07 21 83198 816 34872896
Maculopathy 30.40 11.07 22 83197 924 34872788
Abdominal discomfort 30.37 11.07 245 82974 59590 34814122
Mechanical ventilation 30.37 11.07 30 83189 1940 34871772
Neoplasm progression 30.11 11.07 9 83210 23291 34850421
Inappropriate schedule of product administration 29.73 11.07 65 83154 62231 34811481
Expired product administered 29.39 11.07 38 83181 3303 34870409
Therapeutic response unexpected 29.37 11.07 69 83150 9688 34864024
Infusion site swelling 29.22 11.07 33 83186 2491 34871221
Disseminated intravascular coagulation 28.98 11.07 8 83211 21808 34851904
Catheter site inflammation 28.94 11.07 13 83206 213 34873499
Sepsis 28.63 11.07 256 82963 166305 34707407
Therapy non-responder 28.50 11.07 175 83044 38971 34834741
Macrophages increased 28.42 11.07 12 83207 168 34873544
Scleroderma 28.14 11.07 26 83193 1546 34872166
Interstitial lung disease 28.06 11.07 72 83147 65210 34808502
Penile vein thrombosis 27.98 11.07 7 83212 13 34873699
Lymphocyte count abnormal 27.87 11.07 23 83196 1175 34872537
Myelosuppression 27.67 11.07 6 83213 19259 34854453
Acute respiratory failure 27.61 11.07 146 83073 30782 34842930
Photophobia 27.55 11.07 55 83164 6909 34866803
Medical device change 27.50 11.07 11 83208 133 34873579
Thunderclap headache 27.42 11.07 11 83208 134 34873578
Tumour lysis syndrome 27.35 11.07 4 83215 17055 34856657
Dehydration 27.33 11.07 189 83030 129780 34743932
Device connection issue 27.00 11.07 15 83204 394 34873318
Hallucination 26.90 11.07 51 83168 51447 34822265
Optic disc disorder 26.82 11.07 9 83210 63 34873649
Multiple organ dysfunction syndrome 26.74 11.07 93 83126 76473 34797239
Hepatotoxicity 26.52 11.07 9 83210 21476 34852236
Brain natriuretic peptide increased 26.47 11.07 48 83171 5611 34868101
Atrial septal defect repair 26.43 11.07 10 83209 103 34873609
Catheter removal 26.26 11.07 12 83207 205 34873507
Delirium 26.25 11.07 40 83179 43951 34829761
Right ventricular dysfunction 26.16 11.07 22 83197 1154 34872558
Retinal toxicity 25.97 11.07 15 83204 425 34873287
Rash 25.85 11.07 374 82845 222378 34651334
Aspiration pleural cavity 25.70 11.07 19 83200 825 34872887
Somnolence 25.69 11.07 157 83062 110959 34762753
Onychomycosis 25.47 11.07 30 83189 2370 34871342
Product use issue 25.44 11.07 246 82973 62970 34810742
Chorioretinopathy 25.40 11.07 24 83195 1469 34872243
Plasma cell myeloma 25.30 11.07 38 83181 41999 34831713
Hypoglossal nerve paralysis 25.21 11.07 5 83214 0 34873712
Cardiac index increased 25.17 11.07 7 83212 23 34873689
Hyperkalaemia 25.11 11.07 83 83136 69306 34804406
Osteonecrosis of jaw 24.84 11.07 6 83213 17883 34855829
Ejaculation disorder 24.79 11.07 20 83199 989 34872723
Infusion site inflammation 24.75 11.07 8 83211 49 34873663
Blood culture negative 24.72 11.07 7 83212 25 34873687
Infusion site warmth 24.70 11.07 10 83209 125 34873587
Lactic acidosis 24.45 11.07 28 83191 34744 34838968
Patent ductus arteriosus repair 24.40 11.07 6 83213 10 34873702
Congestive hepatopathy 24.21 11.07 26 83193 1855 34871857
Ejaculation failure 24.16 11.07 18 83201 791 34872921
Cor pulmonale 24.02 11.07 18 83201 798 34872914
Cardioversion 23.97 11.07 19 83200 916 34872796
Lung disorder 23.95 11.07 153 83066 34543 34839169
Acute myeloid leukaemia 23.72 11.07 7 83212 18263 34855449
Product contamination 23.68 11.07 17 83202 705 34873007
Retinal vascular occlusion 23.60 11.07 11 83208 197 34873515
Catheterisation cardiac abnormal 23.60 11.07 8 83211 58 34873654
Infusion site irritation 23.52 11.07 12 83207 264 34873448
Pneumocystis jirovecii pneumonia 23.07 11.07 9 83210 19701 34854011
Abdominal pain 22.93 11.07 264 82955 163354 34710358
Device infusion issue 22.72 11.07 18 83201 867 34872845
Drug interaction 22.63 11.07 390 82829 225556 34648156
Infusion site scar 22.52 11.07 7 83212 37 34873675
Balloon atrial septostomy 22.50 11.07 6 83213 16 34873696
Sedation 22.36 11.07 11 83208 20995 34852717
Macular oedema 22.35 11.07 31 83188 2883 34870829
Bronchopulmonary aspergillosis 22.24 11.07 4 83215 14655 34859057
Toxic epidermal necrolysis 22.05 11.07 12 83207 21634 34852078
Blood cholesterol increased 21.90 11.07 102 83117 20441 34853271
Drug abuse 21.88 11.07 142 83077 98954 34774758
Sinus congestion 21.85 11.07 44 83175 5561 34868151
Drug eruption 21.82 11.07 10 83209 19888 34853824
Neuropathy peripheral 21.76 11.07 113 83106 83150 34790562
Blood testosterone decreased 21.72 11.07 38 83181 4319 34869393
Colour blindness acquired 21.62 11.07 8 83211 77 34873635
Carbon dioxide increased 21.56 11.07 19 83200 1062 34872650
Weight increased 21.18 11.07 325 82894 92708 34781004
Macular degeneration 21.03 11.07 26 83193 2160 34871552
Chronic obstructive pulmonary disease 20.99 11.07 193 83026 48725 34824987
Dysphagia 20.96 11.07 77 83142 62304 34811408
Candida infection 20.88 11.07 8 83211 17707 34856005
Palmar-plantar erythrodysaesthesia syndrome 20.79 11.07 7 83212 16788 34856924
Hyperglycaemia 20.70 11.07 39 83180 39441 34834271
Swelling 20.70 11.07 172 83047 42194 34831518
Polyneuropathy 20.67 11.07 5 83214 14891 34858821
Sudden death 20.46 11.07 81 83138 15120 34858592
Device maintenance issue 20.46 11.07 5 83214 8 34873704
Infusion site discomfort 20.37 11.07 10 83209 202 34873510
Epistaxis 20.25 11.07 220 82999 58031 34815681
Catheter site extravasation 20.20 11.07 8 83211 94 34873618
Optic atrophy 20.13 11.07 17 83202 897 34872815
Product quality issue 19.97 11.07 87 83132 16948 34856764
Dizziness exertional 19.89 11.07 10 83209 213 34873499
Pneumonia aspiration 19.76 11.07 44 83175 41859 34831853
Urticaria 19.67 11.07 79 83140 62298 34811414
Dialysis 19.57 11.07 65 83154 11143 34862569
Rhinovirus infection 19.52 11.07 36 83183 4263 34869449
Carotid artery dissection 19.48 11.07 9 83210 158 34873554
Genital swelling 19.42 11.07 9 83210 159 34873553
Cor pulmonale chronic 19.33 11.07 7 83212 63 34873649
Loss of consciousness 19.28 11.07 290 82929 82377 34791335
Implant site extravasation 19.17 11.07 12 83207 395 34873317
Micrococcus test positive 19.12 11.07 5 83214 12 34873700
Anorgasmia 18.99 11.07 16 83203 841 34872871
Male orgasmic disorder 18.95 11.07 8 83211 112 34873600
Penis disorder 18.91 11.07 19 83200 1254 34872458
Therapy cessation 18.63 11.07 85 83134 16888 34856824
Chest discomfort 18.51 11.07 205 83014 54325 34819387
Unevaluable event 18.51 11.07 137 83082 32453 34841259
Myoclonus 18.47 11.07 6 83213 14719 34858993
Presyncope 18.42 11.07 92 83127 18967 34854745
Respiratory syncytial virus infection 18.40 11.07 37 83182 4672 34869040
Spontaneous intrahepatic portosystemic venous shunt 18.32 11.07 5 83214 15 34873697
Photopsia 18.28 11.07 23 83196 1945 34871767
Hepatitis 18.20 11.07 18 83201 23886 34849826
Cough 18.17 11.07 477 82742 149663 34724049
Pulmonary embolism 18.13 11.07 132 83087 89614 34784098
Blood pressure decreased 18.10 11.07 195 83024 51320 34822392
Pulmonary capillary haemangiomatosis 17.85 11.07 5 83214 17 34873695
Oxygen saturation abnormal 17.71 11.07 20 83199 1510 34872202
Hypocalcaemia 17.69 11.07 19 83200 24270 34849442
Myelodysplastic syndrome 17.68 11.07 12 83207 19196 34854516
Suture insertion 17.64 11.07 6 83213 44 34873668
Conjunctival hyperaemia 17.60 11.07 25 83194 2377 34871335
Cardiac ablation 17.58 11.07 17 83202 1071 34872641
Hypoacusis 17.42 11.07 81 83138 16220 34857492
Road traffic accident 17.41 11.07 85 83134 17365 34856347
Vasculitis 17.32 11.07 3 83216 11293 34862419
Cardiac failure acute 17.31 11.07 60 83159 10510 34863202
Aspergillus infection 17.23 11.07 4 83215 12250 34861462
Tracheitis 17.22 11.07 14 83205 700 34873012
Device physical property issue 17.09 11.07 15 83204 834 34872878
Ocular vascular disorder 17.08 11.07 8 83211 145 34873567
Penile swelling 17.07 11.07 15 83204 835 34872877
Neurotoxicity 16.92 11.07 11 83208 17999 34855713
Lymphadenopathy 16.87 11.07 26 83193 28437 34845275
Blood ethanol increased 16.86 11.07 12 83207 491 34873221
Sudden cardiac death 16.81 11.07 31 83188 3670 34870042
Haemophagocytic lymphohistiocytosis 16.78 11.07 5 83214 12968 34860744
Hypothyroidism 16.78 11.07 15 83204 20887 34852825
Vasodilatation 16.76 11.07 17 83202 1135 34872577
Papilloedema 16.67 11.07 26 83193 2687 34871025
Metastases to bone 16.65 11.07 4 83215 11966 34861746
Right-to-left cardiac shunt 16.58 11.07 7 83212 98 34873614
Vitreous detachment 16.51 11.07 15 83204 873 34872839
Stent placement 16.48 11.07 37 83182 5041 34868671
Atrial flutter 16.36 11.07 77 83142 15497 34858215
Catheter site discolouration 16.32 11.07 5 83214 25 34873687
Hyperbilirubinaemia 16.22 11.07 10 83209 16833 34856879
Hypophagia 16.18 11.07 20 83199 24002 34849710
Heart valve operation 15.92 11.07 6 83213 61 34873651
Thrombotic microangiopathy 15.91 11.07 3 83216 10627 34863085
Constipation 15.86 11.07 230 82989 136752 34736960
Blood creatinine increased 15.85 11.07 147 83072 94829 34778883
Chloropsia 15.80 11.07 4 83215 8 34873704
Pulmonary vascular resistance abnormality 15.75 11.07 6 83213 63 34873649
Full blood count decreased 15.73 11.07 12 83207 18076 34855636
Blood lactate dehydrogenase increased 15.64 11.07 19 83200 22971 34850741
Device breakage 15.49 11.07 23 83196 2277 34871435
Transplant 15.45 11.07 14 83205 812 34872900
Hernia repair 15.36 11.07 17 83202 1255 34872457
Lymphopenia 15.31 11.07 10 83209 16325 34857387
Retinal disorder 15.29 11.07 15 83204 962 34872750
Acute right ventricular failure 15.25 11.07 7 83212 121 34873591
Transplant rejection 15.24 11.07 3 83216 10308 34863404
Hallucination, visual 15.23 11.07 12 83207 17779 34855933
Catheter site scab 15.18 11.07 4 83215 10 34873702
Pulmonary congestion 15.16 11.07 69 83150 13696 34860016
Diuretic therapy 15.15 11.07 5 83214 33 34873679
Respiratory depression 15.15 11.07 10 83209 16235 34857477
Hypercalcaemia 15.15 11.07 9 83210 15459 34858253
Encephalopathy 15.13 11.07 39 83180 35280 34838432
Viral labyrinthitis 15.13 11.07 3 83216 0 34873712
Orchidopexy 15.13 11.07 3 83216 0 34873712
Lymphocyte count decreased 15.07 11.07 19 83200 22603 34851109
Blood pressure abnormal 15.04 11.07 48 83171 8058 34865654
Hyperinsulinaemic hypoglycaemia 15.04 11.07 6 83213 72 34873640
Thoracic cavity drainage 15.01 11.07 8 83211 193 34873519
Viral upper respiratory tract infection 14.94 11.07 25 83194 2741 34870971
Glomerular filtration rate abnormal 14.92 11.07 14 83205 849 34872863
Epstein-Barr virus antibody positive 14.49 11.07 9 83210 292 34873420
Therapeutic procedure 14.47 11.07 8 83211 208 34873504
Pulmonary arterial pressure abnormal 14.44 11.07 8 83211 209 34873503
Oesophageal variceal ligation 14.41 11.07 6 83213 81 34873631
Anaphylactic reaction 14.36 11.07 35 83184 32266 34841446
Coma 14.30 11.07 58 83161 45620 34828092
Infusion site vesicles 14.30 11.07 8 83211 213 34873499
Heart rate increased 14.29 11.07 171 83048 46172 34827540
Vertebral artery stenosis 14.28 11.07 7 83212 141 34873571
Retinal haemorrhage 14.25 11.07 35 83184 5054 34868658
Right atrial pressure increased 14.21 11.07 6 83213 84 34873628
Lymphocyte count 14.21 11.07 6 83213 84 34873628
Pulmonary arterial pressure decreased 14.19 11.07 4 83215 14 34873698
Bronchiectasis 14.18 11.07 3 83216 9798 34863914
Dialysis related complication 14.14 11.07 7 83212 144 34873568
Cardiac pacemaker insertion 14.09 11.07 25 83194 2873 34870839
Peritonitis 14.05 11.07 11 83208 16354 34857358
Tinnitus 14.05 11.07 89 83130 20029 34853683
Blood creatine phosphokinase increased 14.02 11.07 57 83162 44800 34828912
Fibrinous bronchitis 13.97 11.07 4 83215 15 34873697
Psoriatic arthropathy 13.85 11.07 16 83203 19782 34853930
Chronic respiratory failure 13.75 11.07 17 83202 1412 34872300
Food interaction 13.75 11.07 14 83205 939 34872773
Dyskinesia 13.74 11.07 20 83199 22393 34851319
Sudden hearing loss 13.69 11.07 14 83205 944 34872768
Phlebotomy 13.66 11.07 6 83213 93 34873619
Toxic skin eruption 13.66 11.07 5 83214 11380 34862332
Decreased appetite 13.65 11.07 297 82922 166095 34707617
Executive dysfunction 13.62 11.07 8 83211 234 34873478
Transaminases increased 13.62 11.07 27 83192 26796 34846916
Mineral supplementation 13.60 11.07 6 83213 94 34873618
Infusion site induration 13.56 11.07 8 83211 236 34873476
Endarterectomy 13.56 11.07 7 83212 158 34873554
Glare 13.54 11.07 6 83213 95 34873617
Retinitis pigmentosa 13.52 11.07 5 83214 48 34873664
Substance use 13.45 11.07 12 83207 682 34873030
Hepatic cytolysis 13.42 11.07 9 83210 14487 34859225
Emergency care 13.37 11.07 9 83210 336 34873376
Right ventricular dilatation 13.34 11.07 12 83207 689 34873023
Metastases to liver 13.31 11.07 8 83211 13655 34860057
Reversible cerebral vasoconstriction syndrome 13.27 11.07 10 83209 447 34873265
Chest tube insertion 13.21 11.07 6 83213 101 34873611
Blood pressure fluctuation 13.18 11.07 25 83194 25224 34848488
Mobility decreased 13.11 11.07 33 83186 30095 34843617
Nodular melanoma 13.11 11.07 6 83213 103 34873609
Fasciectomy 13.06 11.07 3 83216 3 34873709
Hereditary haemorrhagic telangiectasia 13.06 11.07 3 83216 3 34873709
Ileus 13.05 11.07 12 83207 16487 34857225
Product taste abnormal 13 11.07 15 83204 1159 34872553
Hypophosphataemia 12.96 11.07 5 83214 11021 34862691
COVID-19 12.95 11.07 120 83099 77430 34796282
Bronchopulmonary dysplasia 12.92 11.07 11 83208 587 34873125
Bradycardia 12.90 11.07 116 83103 75302 34798410
Infusion site reaction 12.84 11.07 13 83206 866 34872846
Libido decreased 12.84 11.07 32 83187 4664 34869048
Deafness transitory 12.76 11.07 5 83214 57 34873655
Sensation of blood flow 12.60 11.07 3 83216 4 34873708
Exercise test abnormal 12.60 11.07 3 83216 4 34873708
Basal cell carcinoma 12.59 11.07 17 83202 19641 34854071
Retinal deposits 12.59 11.07 4 83215 23 34873689
Catheter site mass 12.59 11.07 4 83215 23 34873689
Hypothermia 12.43 11.07 5 83214 10743 34862969
Exposure during pregnancy 12.40 11.07 3 83216 8931 34864781
Epilepsy 12.39 11.07 20 83199 21475 34852237
Melaena 12.33 11.07 43 83176 35337 34838375
Lung assist device therapy 12.31 11.07 4 83215 25 34873687
Deep vein thrombosis 12.21 11.07 98 83121 65150 34808562
Catheter site dermatitis 12.20 11.07 3 83216 5 34873707
Corneal abrasion 12.19 11.07 8 83211 286 34873426
Body temperature decreased 12.19 11.07 8 83211 13026 34860686
Infusion site abscess 12.17 11.07 4 83215 26 34873686
Insulin autoimmune syndrome 12.14 11.07 8 83211 288 34873424
Gastrointestinal surgery 12.11 11.07 5 83214 66 34873646
Hypoalbuminaemia 12.04 11.07 7 83212 12167 34861545
Retinal vein thrombosis 11.93 11.07 9 83210 403 34873309
Injection site pain 11.92 11.07 50 83169 38955 34834757
Retinal infarction 11.88 11.07 6 83213 129 34873583
Schizophrenia 11.85 11.07 3 83216 8663 34865049
Micrococcus infection 11.85 11.07 3 83216 6 34873706
Intentional product misuse 11.82 11.07 163 83056 45448 34828264
Therapeutic product effect delayed 11.79 11.07 15 83204 1283 34872429
Orgasm abnormal 11.72 11.07 6 83213 133 34873579
Catheter site vesicles 11.68 11.07 4 83215 30 34873682
Vascular operation 11.68 11.07 4 83215 30 34873682
Thrombosis in device 11.67 11.07 25 83194 3300 34870412
Altered state of consciousness 11.66 11.07 23 83196 22870 34850842
Adulterated product 11.57 11.07 4 83215 31 34873681
Inflammation 11.55 11.07 32 83187 28263 34845449
Wheezing 11.49 11.07 55 83164 41347 34832365
Nephropathy toxic 11.41 11.07 8 83211 12580 34861132
Internal haemorrhage 11.39 11.07 32 83187 5009 34868703
Angioplasty 11.34 11.07 13 83206 997 34872715
Respiratory tract infection viral 11.33 11.07 21 83198 2496 34871216
Cognitive disorder 11.31 11.07 33 83186 28660 34845052
Muscular weakness 11.24 11.07 115 83104 72782 34800930
Respiratory failure 11.18 11.07 338 82881 108234 34765478
Blood calcium decreased 11.16 11.07 5 83214 10079 34863633
Haemoptysis 11.15 11.07 130 83089 34876 34838836
Tracheostomy infection 11.15 11.07 4 83215 35 34873677
Alopecia 11.13 11.07 26 83193 24329 34849383
Hypomagnesaemia 11.09 11.07 22 83197 21829 34851883

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pulmonary arterial hypertension 3131.15 11.23 1454 181767 26912 79534255
Dyspnoea 2362.98 11.23 5697 177524 851328 78709839
Right ventricular failure 2191.53 11.23 1073 182148 22424 79538743
Fluid retention 2191.07 11.23 1576 181645 68233 79492934
Pulmonary hypertension 1943.09 11.23 1269 181952 46811 79514356
Pain in jaw 1633.75 11.23 1122 182099 45029 79516138
Death 1481.91 11.23 3699 179522 562815 78998352
Hypervolaemia 1128.63 11.23 870 182351 41820 79519347
Headache 949.03 11.23 3471 179750 650301 78910866
Dyspnoea exertional 861.45 11.23 1031 182190 86042 79475125
Catheter site erythema 719.05 11.23 313 182908 4927 79556240
Lung transplant 663.76 11.23 284 182937 4277 79556890
Flushing 639.30 11.23 896 182325 87372 79473795
Oxygen saturation decreased 606.50 11.23 1074 182147 127973 79433194
Nasal congestion 591.81 11.23 802 182419 75750 79485417
Transfusion 590.57 11.23 447 182774 20883 79540284
Catheter management 509.77 11.23 221 183000 3442 79557725
Device related infection 505.02 11.23 501 182720 33793 79527374
Catheter site pruritus 493.15 11.23 189 183032 2102 79559065
Oedema 479.90 11.23 930 182291 118650 79442517
Neutropenia 448.58 11.23 64 183157 287646 79273521
Catheterisation cardiac 447.02 11.23 232 182989 5496 79555671
Hospitalisation 440.91 11.23 783 182438 93453 79467714
Catheter site pain 422.38 11.23 219 183002 5177 79555990
Infusion site pain 421.26 11.23 310 182911 13866 79547301
Pulmonary arterial pressure increased 397.66 11.23 199 183022 4356 79556811
Infusion related reaction 396.91 11.23 36 183185 230201 79330966
Hypoxia 396.07 11.23 788 182433 102455 79458712
Chest pain 393.93 11.23 1483 181738 280821 79280346
Catheter site discharge 383.66 11.23 160 183061 2252 79558915
Febrile neutropenia 382.86 11.23 42 183179 230957 79330210
Syncope 377.39 11.23 1084 182137 178365 79382802
Toxicity to various agents 370.63 11.23 258 182963 421282 79139885
Oedema peripheral 368.37 11.23 1345 181876 250943 79310224
Cardiac failure 358.73 11.23 969 182252 153873 79407294
Oxygen consumption increased 338.64 11.23 184 183037 4795 79556372
Catheter site infection 325.76 11.23 200 183021 6595 79554572
Pulmonary oedema 314.01 11.23 653 182568 87601 79473566
Catheter placement 292.69 11.23 141 183080 2833 79558334
Central venous catheterisation 279.22 11.23 141 183080 3148 79558019
Palpitations 268.13 11.23 767 182454 125843 79435324
Treatment failure 267.75 11.23 37 183184 170449 79390718
Rheumatoid arthritis 265.37 11.23 75 183146 208395 79352772
Alopecia 265.01 11.23 100 183121 231255 79329912
Cardiac failure congestive 261.25 11.23 820 182401 141582 79419585
Completed suicide 257.82 11.23 121 183100 245646 79315521
Dizziness 250.55 11.23 2064 181157 524377 79036790
Malignant neoplasm progression 249.14 11.23 16 183205 135974 79425193
Device alarm issue 248.78 11.23 113 183108 1976 79559191
Infusion site erythema 248.10 11.23 192 183029 9268 79551899
Cough 247.88 11.23 1565 181656 365224 79195943
Contraindicated product administered 245.49 11.23 35 183186 157503 79403664
Catheter site swelling 241.88 11.23 107 183114 1753 79559414
Scleroderma 240.99 11.23 153 183068 5357 79555810
Cardiac disorder 237.92 11.23 490 182731 65267 79495900
Optic ischaemic neuropathy 228.38 11.23 119 183102 2842 79558325
Drug hypersensitivity 220.38 11.23 217 183004 298699 79262468
Hypotension 218.34 11.23 1743 181478 438574 79122593
Unevaluable event 212.73 11.23 424 182797 55161 79506006
Stomatitis 210.04 11.23 41 183180 146716 79414451
Drug ineffective 209.53 11.23 1541 181680 1079372 78481795
Infusion site infection 207.87 11.23 95 183126 1686 79559481
Catheter site haemorrhage 203.87 11.23 134 183087 4983 79556184
Rash 203.30 11.23 667 182554 577691 78983476
Off label use 202.88 11.23 1239 181982 905976 78655191
Cardiac operation 199.08 11.23 131 183090 4881 79556286
Device leakage 196.81 11.23 178 183043 10678 79550489
Transplant evaluation 196.44 11.23 90 183131 1607 79559560
Respiratory failure 191.80 11.23 874 182347 180037 79381130
Drug interaction 186.08 11.23 425 182796 414758 79146409
Joint swelling 183.85 11.23 236 182985 288410 79272757
Acute respiratory failure 179.24 11.23 412 182809 59129 79502038
Arthropathy 178.41 11.23 92 183129 177019 79384148
Glossodynia 178.41 11.23 16 183205 103321 79457846
Concomitant disease aggravated 176.70 11.23 183 183038 12984 79548183
Condition aggravated 173.87 11.23 1837 181384 499287 79061880
Catheter site rash 171.14 11.23 70 183151 935 79560232
Pulmonary veno-occlusive disease 170.91 11.23 81 183140 1567 79559600
Musculoskeletal stiffness 168.85 11.23 96 183125 174912 79386255
Malaise 168.64 11.23 1793 181428 488076 79073091
Device occlusion 166.63 11.23 169 183052 11697 79549470
Complication associated with device 166.00 11.23 203 183018 17293 79543874
Pulmonary hypertensive crisis 164.17 11.23 52 183169 308 79560859
Pneumonia 162.26 11.23 2267 180954 657979 78903188
Therapeutic product effect decreased 157.92 11.23 90 183131 163773 79397394
Hepatic enzyme increased 155.98 11.23 115 183106 182495 79378672
Leukopenia 153.72 11.23 39 183182 116474 79444693
Product use in unapproved indication 150.98 11.23 213 183008 250146 79311021
Therapy change 149.47 11.23 129 183092 7270 79553897
Thrombocytopenia 147.11 11.23 239 182982 265020 79296147
Catheter site irritation 146.07 11.23 54 183167 539 79560628
Pericarditis 145.23 11.23 31 183190 104205 79456962
White blood cell count decreased 141.81 11.23 134 183087 188154 79373013
Mucosal inflammation 141.11 11.23 8 183213 75572 79485595
Hypersensitivity 141.04 11.23 241 182980 261998 79299169
Urticaria 140.42 11.23 131 183090 185070 79376097
Acute kidney injury 140.28 11.23 665 182556 518739 79042428
Pruritus 139.94 11.23 453 182768 394195 79166972
Drug intolerance 137.27 11.23 248 182973 263871 79297296
Product dose omission issue 137.00 11.23 1006 182215 246531 79314636
Epistaxis 135.91 11.23 562 182659 110953 79450214
Cyanopsia 133.88 11.23 33 183188 59 79561108
Neutrophil count decreased 132.85 11.23 27 183194 93932 79467235
Diarrhoea 130.84 11.23 2788 180433 877701 78683466
Chest discomfort 126.75 11.23 640 182581 137404 79423763
Erection increased 125.45 11.23 43 183178 337 79560830
Brain natriuretic peptide increased 125.42 11.23 127 183094 8773 79552394
Right ventricular dysfunction 124.88 11.23 77 183144 2558 79558609
Paracentesis 124.04 11.23 61 183160 1284 79559883
Exercise tolerance decreased 123.39 11.23 127 183094 8944 79552223
Device dislocation 122.90 11.23 217 183004 25753 79535414
Myalgia 121.96 11.23 787 182434 184854 79376313
Catheter site inflammation 121.15 11.23 57 183164 1084 79560083
Disease progression 120.15 11.23 780 182441 183582 79377585
Dialysis 119.76 11.23 178 183043 18284 79542883
Confusional state 118.34 11.23 357 182864 317640 79243527
Infusion site swelling 118.26 11.23 116 183105 7710 79553457
Electrocardiogram QT prolonged 115.91 11.23 32 183189 90354 79470813
Psoriatic arthropathy 115.42 11.23 20 183201 77979 79483188
Duodenal ulcer perforation 114.96 11.23 10 183211 66201 79494966
Pancytopenia 113.43 11.23 128 183093 165617 79395550
Mobility decreased 112.23 11.23 71 183150 122104 79439063
Infusion site discharge 111.81 11.23 45 183176 575 79560592
Maternal exposure during pregnancy 111.47 11.23 90 183131 136448 79424719
Oxygen therapy 111.00 11.23 73 183148 2717 79558450
N-terminal prohormone brain natriuretic peptide increased 110.73 11.23 90 183131 4665 79556502
Device infusion issue 110.31 11.23 68 183153 2258 79558909
Pericardial effusion 107.55 11.23 290 182931 45947 79515220
Heart transplant 107.06 11.23 57 183164 1424 79559743
Helicobacter infection 105.08 11.23 17 183204 69687 79491480
C-reactive protein increased 104.15 11.23 86 183135 128941 79432226
Cyanosis 103.51 11.23 198 183023 24984 79536183
Folliculitis 102.96 11.23 6 183215 55374 79505793
Feeling abnormal 102.16 11.23 671 182550 158528 79402639
Presyncope 102.11 11.23 264 182957 40790 79520377
Ascites 101.82 11.23 393 182828 75169 79485998
Impaired healing 100.10 11.23 38 183183 87617 79473550
Dermatitis contact 99.82 11.23 125 183096 10908 79550259
Hyponatraemia 98.77 11.23 160 183061 177688 79383479
Vascular device infection 98.73 11.23 120 183101 10156 79551011
Blister 98.47 11.23 78 183143 119398 79441769
Pain in extremity 96.75 11.23 1270 181951 363268 79197899
Anaphylactic reaction 96.14 11.23 36 183185 83707 79477460
Injection site pain 94.72 11.23 95 183126 129743 79431424
Wound 94.31 11.23 77 183144 116102 79445065
Cardiac pacemaker insertion 93.06 11.23 89 183132 5733 79555434
Drug abuse 92.58 11.23 144 183077 162547 79398620
Walking distance test abnormal 91.31 11.23 41 183180 697 79560470
Psoriasis 90.98 11.23 46 183175 89541 79471626
Therapeutic product effect incomplete 90.94 11.23 115 183106 141530 79419637
Suspected counterfeit product 90.28 11.23 38 183183 548 79560619
Atrial flutter 90.07 11.23 171 183050 21454 79539713
Agranulocytosis 89.87 11.23 3 183218 45027 79516140
Cardiac ablation 89.76 11.23 59 183162 2194 79558973
Inappropriate schedule of product administration 89.47 11.23 105 183116 133523 79427644
Erectile dysfunction 88.89 11.23 137 183084 14527 79546640
Rash maculo-papular 88.40 11.23 12 183209 56066 79505101
Fibromyalgia 87.87 11.23 20 183201 64320 79496847
Heart and lung transplant 87.81 11.23 28 183193 170 79560997
Emergency care 87.73 11.23 45 183176 1039 79560128
Hypertension 86.19 11.23 429 182792 330563 79230604
Osteonecrosis of jaw 85.84 11.23 3 183218 43223 79517944
Catheter site related reaction 85.44 11.23 46 183175 1176 79559991
Haemoptysis 85.28 11.23 303 182918 55696 79505471
Heart rate increased 84.96 11.23 521 182700 120203 79440964
Dyspnoea at rest 84.78 11.23 94 183127 7208 79553959
Cor pulmonale 84.58 11.23 57 183164 2211 79558956
Neoplasm progression 84.03 11.23 10 183211 51672 79509495
Bone marrow failure 82.82 11.23 10 183211 51097 79510070
Infusion site haemorrhage 81.58 11.23 68 183153 3652 79557515
Influenza 81.15 11.23 543 182678 129063 79432104
Sleep disorder due to general medical condition, insomnia type 80.12 11.23 5 183216 43551 79517616
Peripheral swelling 79.89 11.23 959 182262 268658 79292509
Discomfort 79.58 11.23 103 183118 125514 79435653
Lower respiratory tract infection 78.77 11.23 109 183112 129111 79432056
Balloon atrial septostomy 78.65 11.23 23 183198 99 79561068
Drug reaction with eosinophilia and systemic symptoms 78.26 11.23 25 183196 64219 79496948
Atrial septal defect repair 78.19 11.23 32 183189 428 79560739
Abdominal distension 77.76 11.23 506 182715 119144 79442023
Intentional product use issue 76.17 11.23 146 183075 151966 79409201
Blood pressure decreased 75.59 11.23 438 182783 99028 79462139
Tracheostomy 75.54 11.23 43 183178 1229 79559938
Arthralgia 74.57 11.23 898 182323 570905 78990262
Mechanical ventilation 74.44 11.23 57 183164 2707 79558460
Chronic obstructive pulmonary disease 73.49 11.23 389 182832 85030 79476137
Catheter removal 73.21 11.23 34 183187 627 79560540
Sedation 73.17 11.23 15 183206 51880 79509287
Irritable bowel syndrome 72.72 11.23 26 183195 62215 79498952
Intentional overdose 72.29 11.23 82 183139 105878 79455289
Medical device change 71.60 11.23 31 183190 481 79560686
General physical health deterioration 71.48 11.23 357 182864 274881 79286286
Blood pressure increased 71.12 11.23 248 182973 211112 79350055
Coma 70.75 11.23 76 183145 100573 79460594
Toxic epidermal necrolysis 69.19 11.23 10 183211 44571 79516596
Delirium 68.79 11.23 56 183165 84571 79476596
Muscle injury 68.54 11.23 14 183207 48547 79512620
Neuropathy peripheral 67.84 11.23 139 183082 141166 79420001
Cardioversion 67.15 11.23 48 183173 2050 79559117
Drug resistance 66.61 11.23 9 183212 42204 79518963
Right ventricular dilatation 66.13 11.23 46 183175 1880 79559287
Congestive hepatopathy 66.12 11.23 66 183155 4481 79556686
Catheter site vesicles 65.99 11.23 26 183195 313 79560854
Liver transplant 65.79 11.23 65 183156 4358 79556809
Myelosuppression 65.01 11.23 8 183213 40288 79520879
Drug-induced liver injury 64.12 11.23 36 183185 66081 79495086
Injection site bruising 64.09 11.23 9 183212 40993 79520174
Stent placement 64.05 11.23 77 183144 6443 79554724
Device connection issue 63.78 11.23 36 183185 1012 79560155
Device breakage 63.68 11.23 99 183122 10576 79550591
Vascular resistance pulmonary increased 63.68 11.23 19 183202 89 79561078
Aspiration pleural cavity 63.58 11.23 42 183179 1575 79559592
Systemic lupus erythematosus 63.56 11.23 113 183108 121036 79440131
Device related sepsis 63.45 11.23 75 183146 6165 79555002
Lung disorder 63.34 11.23 358 182863 80199 79480968
Productive cough 63.27 11.23 383 182838 87948 79473219
Biopsy liver 62.48 11.23 30 183191 598 79560569
Suicide attempt 62.42 11.23 59 183162 82873 79478294
Ventilation perfusion mismatch 61.94 11.23 30 183191 610 79560557
Red blood cell sedimentation rate increased 61.31 11.23 15 183206 45927 79515240
Cytomegalovirus infection 60.80 11.23 12 183209 42632 79518535
Injection site erythema 60.80 11.23 54 183167 78143 79483024
Injection site reaction 60.49 11.23 25 183196 54760 79506407
Lactic acidosis 60.44 11.23 44 183177 70315 79490852
Therapy non-responder 60.36 11.23 391 182830 91914 79469253
Sopor 60.09 11.23 4 183217 33006 79528161
Thrombosis in device 59.67 11.23 68 183153 5374 79555793
Metabolic acidosis 59.48 11.23 61 183160 82468 79478699
Infusion site irritation 59.43 11.23 31 183190 742 79560425
Osteoarthritis 59.09 11.23 68 183153 87241 79473926
Oxygen saturation abnormal 58.47 11.23 62 183159 4520 79556647
Depressed level of consciousness 58.43 11.23 82 183139 96570 79464597
Inflammation 58.23 11.23 78 183143 93675 79467492
Viral infection 58.16 11.23 224 182997 42792 79518375
Chronic respiratory failure 57.65 11.23 51 183170 2971 79558196
Priapism 57.56 11.23 61 183160 4444 79556723
Transplant 56.99 11.23 33 183188 975 79560192
Systemic scleroderma 56.78 11.23 35 183186 1162 79560005
Cytokine release syndrome 56.04 11.23 8 183213 35990 79525177
Right ventricular hypertrophy 55.98 11.23 39 183182 1598 79559569
Thrombosis corpora cavernosa 55.86 11.23 11 183210 0 79561167
Counterfeit product administered 55.41 11.23 18 183203 117 79561050
Catheter site extravasation 55.20 11.23 25 183196 434 79560733
Palmar-plantar erythrodysaesthesia syndrome 54.90 11.23 6 183215 33128 79528039
Catheterisation cardiac abnormal 54.81 11.23 22 183199 279 79560888
Disease complication 54.66 11.23 62 183159 4875 79556292
Abdominal cavity drainage 54.58 11.23 30 183191 800 79560367
Drug eruption 53.68 11.23 17 183204 43918 79517249
Rhinovirus infection 53.48 11.23 78 183143 7875 79553292
Device physical property issue 53.42 11.23 46 183175 2584 79558583
Infusion site warmth 52.91 11.23 36 183185 1419 79559748
Medication error 52.65 11.23 48 183173 68594 79492573
Cardiac failure acute 52.61 11.23 127 183094 18802 79542365
Blood pressure systolic increased 52.38 11.23 46 183175 66940 79494227
Pneumonitis 52.35 11.23 38 183183 60822 79500345
Pulmonary arterial pressure abnormal 52.07 11.23 28 183193 714 79560453
Internal haemorrhage 51.42 11.23 81 183140 8752 79552415
Visual field defect 51.35 11.23 82 183139 8963 79552204
Infusion site pruritus 51.27 11.23 55 183166 4063 79557104
Eosinophilia 51.20 11.23 20 183201 45325 79515842
Pneumocystis jirovecii pneumonia 51.13 11.23 7 183214 32501 79528666
Right ventricular systolic pressure increased 50.46 11.23 30 183191 932 79560235
Patent ductus arteriosus repair 50.24 11.23 13 183208 31 79561136
Terminal state 50.10 11.23 59 183162 4830 79556337
Infusion site abscess 50.08 11.23 19 183202 205 79560962
Lung assist device therapy 50.07 11.23 17 183204 129 79561038
Concomitant disease progression 49.74 11.23 50 183171 3423 79557744
COVID-19 49.73 11.23 190 183031 157484 79403683
Colitis 49.71 11.23 57 183164 73250 79487917
Hyperglycaemia 49.55 11.23 53 183168 70282 79490885
Catheter site scab 49.20 11.23 19 183202 216 79560951
Hallucination 48.66 11.23 76 183145 85669 79475498
Overdose 48.32 11.23 238 182983 183968 79377199
Prescription drug used without a prescription 48.14 11.23 53 183168 4032 79557135
Blood pressure fluctuation 47.97 11.23 50 183171 67095 79494072
Right-to-left cardiac shunt 47.91 11.23 19 183202 233 79560934
Blindness unilateral 47.83 11.23 75 183146 8071 79553096
Acute myeloid leukaemia 47.76 11.23 7 183214 30878 79530289
Pulmonary congestion 47.74 11.23 154 183067 26946 79534221
Infusion site cellulitis 47.73 11.23 20 183201 285 79560882
Blood culture positive 47.28 11.23 76 183145 8353 79552814
Ill-defined disorder 47.12 11.23 49 183172 65826 79495341
Respiratory distress 47.01 11.23 261 182960 58078 79503089
Lymphocyte count decreased 46.94 11.23 25 183196 47264 79513903
Blood culture negative 46.89 11.23 18 183203 201 79560966
Cognitive disorder 46.73 11.23 55 183166 69871 79491296
Gout 46.68 11.23 144 183077 24605 79536562
Paraesthesia 46.14 11.23 228 182993 176095 79385072
Left-to-right cardiac shunt 46.11 11.23 15 183206 98 79561069
Suicidal ideation 45.91 11.23 65 183156 76275 79484892
Infusion site induration 45.89 11.23 30 183191 1105 79560062
Serotonin syndrome 45.89 11.23 23 183198 45004 79516163
Hypocalcaemia 45.85 11.23 29 183192 49895 79511272
Anaphylactic shock 45.66 11.23 13 183208 35983 79525184
Inappropriate antidiuretic hormone secretion 45.60 11.23 4 183217 26309 79534858
Hernia repair 45.60 11.23 38 183183 2040 79559127
Carbon dioxide increased 45.13 11.23 39 183182 2201 79558966
Asthma 45.10 11.23 159 183062 134936 79426231
Sinus congestion 44.48 11.23 123 183098 19773 79541394
Sudden death 44.36 11.23 133 183088 22378 79538789
Blood potassium decreased 44.32 11.23 218 183003 46294 79514873
Nausea 44.26 11.23 2652 180569 954544 78606623
Pulmonary vein stenosis 44.26 11.23 16 183205 149 79561018
Hepatitis 43.90 11.23 38 183183 55689 79505478
Polyneuropathy 43.74 11.23 3 183218 24148 79537019
Biopsy lung 43.57 11.23 18 183203 247 79560920
Hyperkalaemia 43.52 11.23 127 183094 114271 79446896
Catheter site warmth 43.31 11.23 18 183203 251 79560916
Tumour lysis syndrome 43.28 11.23 3 183218 23936 79537231
Therapeutic response decreased 43.18 11.23 54 183167 66799 79494368
Basal cell carcinoma 43.00 11.23 16 183205 37359 79523808
Dizziness postural 42.85 11.23 87 183134 11462 79549705
Prescribed underdose 42.72 11.23 8 183213 29506 79531661
Neurotoxicity 42.65 11.23 11 183210 32507 79528660
Rhabdomyolysis 41.82 11.23 111 183110 103020 79458147
Hypercalcaemia 41.68 11.23 18 183203 38412 79522755
Pulmonary vascular resistance abnormality 41.46 11.23 15 183206 140 79561027
Acute right ventricular failure 41.33 11.23 19 183202 342 79560825
Deep vein thrombosis 41.25 11.23 141 183080 120778 79440389
Dizziness exertional 41.24 11.23 22 183199 552 79560615
Somnolence 41.13 11.23 351 182870 238630 79322537
Injection site pruritus 41.03 11.23 23 183198 42260 79518907
Blood creatine phosphokinase increased 41.02 11.23 55 183166 66035 79495132
Hypothyroidism 40.94 11.23 36 183185 52356 79508811
Oral herpes 40.70 11.23 7 183214 27447 79533720
Respiration abnormal 40.68 11.23 68 183153 7720 79553447
Device malfunction 40.65 11.23 125 183096 21323 79539844
Loss of visual contrast sensitivity 40.63 11.23 8 183213 0 79561167
Blood cholesterol increased 40.47 11.23 82 183139 83638 79477529
Catheter site discolouration 40.38 11.23 14 183207 114 79561053
Type 2 diabetes mellitus 40.28 11.23 43 183178 57079 79504088
Body temperature decreased 40.06 11.23 12 183209 32133 79529034
Heart valve operation 39.85 11.23 16 183205 203 79560964
Liver injury 39.50 11.23 43 183178 56571 79504596
Arthritis 39.15 11.23 134 183087 114746 79446421
Myoclonus 38.98 11.23 8 183213 27652 79533515
Intentional self-injury 38.80 11.23 13 183208 32406 79528761
Grip strength decreased 38.80 11.23 3 183218 21866 79539301
Neutropenic sepsis 37.79 11.23 8 183213 27056 79534111
Respiratory syncytial virus infection 37.50 11.23 73 183148 9329 79551838
Finger amputation 37.33 11.23 22 183199 672 79560495
Ventricular septal defect repair 37.24 11.23 10 183211 29 79561138
Pyrexia 37.12 11.23 1233 181988 677476 78883691
Bursitis 37.00 11.23 18 183203 35826 79525341
Abdominal pain 36.96 11.23 651 182570 388918 79172249
Hepatocellular injury 36.83 11.23 33 183188 47560 79513607
Metastases to bone 36.72 11.23 6 183215 24421 79536746
Plasma cell myeloma 36.55 11.23 41 183180 53218 79507949
Systemic-pulmonary artery shunt 36.27 11.23 10 183211 33 79561134
Dependence on oxygen therapy 36.10 11.23 20 183201 542 79560625
Dysphagia 36.09 11.23 151 183070 121985 79439182
Pulmonary arterial pressure 36.04 11.23 10 183211 34 79561133
Hallucination, visual 36.03 11.23 15 183206 32714 79528453
Foot deformity 35.99 11.23 6 183215 24068 79537099
Endotracheal intubation 35.93 11.23 49 183172 4648 79556519
Peyronie's disease 35.86 11.23 9 183212 18 79561149
Hypomagnesaemia 35.74 11.23 33 183188 46878 79514289
Penile vein thrombosis 35.55 11.23 7 183214 0 79561167
Central venous catheter removal 35.49 11.23 19 183202 480 79560687
Psychotic disorder 35.41 11.23 26 183195 41376 79519791
Lymphopenia 35.29 11.23 13 183208 30544 79530623
Vasodilatation 35.20 11.23 40 183181 3151 79558016
Platelet count decreased 34.81 11.23 283 182938 194381 79366786
Dyskinesia 34.70 11.23 31 183190 44742 79516425
Muscle rigidity 34.52 11.23 3 183218 19879 79541288
Localised oedema 34.51 11.23 64 183157 7888 79553279
Deafness unilateral 34.47 11.23 45 183176 4093 79557074
Infusion site oedema 34.41 11.23 23 183198 880 79560287
Renal disorder 34.34 11.23 189 183032 41916 79519251
Cor pulmonale chronic 34.07 11.23 16 183205 303 79560864
Incorrect route of product administration 33.89 11.23 19 183202 34910 79526257
Injection site swelling 33.77 11.23 35 183186 47097 79514070
Disease recurrence 33.64 11.23 31 183190 44078 79517089
Osteoporosis 33.61 11.23 45 183176 54067 79507100
Fracture of penis 33.41 11.23 13 183208 151 79561016
Loss of consciousness 33.41 11.23 557 182664 167386 79393781
Dialysis related complication 33.30 11.23 15 183206 257 79560910
Altered state of consciousness 33.18 11.23 31 183190 43791 79517376
Myelodysplastic syndrome 33.17 11.23 14 183207 30287 79530880
Catheter site nodule 33.15 11.23 10 183211 49 79561118
Nephropathy toxic 33.07 11.23 4 183217 20415 79540752
Dyschromatopsia 33.07 11.23 22 183199 835 79560332
Deafness 33.03 11.23 115 183106 20922 79540245
Cytopenia 33.00 11.23 4 183217 20379 79540788
Stevens-Johnson syndrome 32.98 11.23 25 183196 39141 79522026
Hypoglycaemia 32.95 11.23 121 183100 101473 79459694
Cholestasis 32.71 11.23 43 183178 52066 79509101
Hypoaesthesia 32.40 11.23 260 182961 179092 79382075
Paranasal sinus hypersecretion 32.31 11.23 42 183179 3804 79557363
Right atrial pressure increased 32.28 11.23 15 183206 277 79560890
Atrial fibrillation 32.22 11.23 636 182585 197250 79363917
Pulmonary arterial wedge pressure increased 31.86 11.23 18 183203 507 79560660
Constipation 31.85 11.23 458 182763 282592 79278575
Abortion spontaneous 31.72 11.23 14 183207 29493 79531674
Retching 31.44 11.23 100 183121 17367 79543800
Haemophagocytic lymphohistiocytosis 31.44 11.23 6 183215 21831 79539336
Cardiac output decreased 31.10 11.23 29 183192 1809 79559358
Progressive multifocal leukoencephalopathy 31.10 11.23 5 183216 20595 79540572
Infusion site rash 31.03 11.23 28 183193 1674 79559493
Pulmonary embolism 30.94 11.23 249 182972 171405 79389762
Epilepsy 30.83 11.23 29 183192 40831 79520336
Gastrostomy 30.82 11.23 24 183197 1169 79559998
Angioplasty 30.77 11.23 29 183192 1834 79559333
Head injury 30.65 11.23 168 183053 37201 79523966
Application site irritation 30.45 11.23 28 183193 1716 79559451
Aplastic anaemia 30.29 11.23 3 183218 17902 79543265
Therapy cessation 30.23 11.23 168 183053 37394 79523773
Bradycardia 30.13 11.23 185 183036 135372 79425795
Pulmonary artery aneurysm 30.12 11.23 12 183209 149 79561018
Encephalopathy 30.10 11.23 69 183152 67328 79493839
Visual impairment 30.05 11.23 334 182887 91797 79469370
Right ventricular enlargement 29.95 11.23 19 183202 664 79560503
Cardiomegaly 29.90 11.23 130 183091 26222 79534945
Respiratory depression 29.87 11.23 13 183208 27617 79533550
Therapeutic embolisation 29.86 11.23 17 183204 486 79560681
Product counterfeit 29.77 11.23 14 183207 266 79560901
Blood pressure abnormal 29.73 11.23 97 183124 17072 79544095
Hepatotoxicity 29.63 11.23 45 183176 51307 79509860
Multiple sclerosis relapse 29.62 11.23 38 183183 46495 79514672
Eczema 29.60 11.23 30 183191 40788 79520379
Sinus disorder 29.56 11.23 116 183105 22348 79538819
Metastases to liver 29.56 11.23 14 183207 28300 79532867
Application site pruritus 29.53 11.23 40 183181 3770 79557397
Vascular resistance pulmonary decreased 29.33 11.23 10 183211 77 79561090
Heart disease congenital 29.30 11.23 18 183203 594 79560573
Painful erection 29.29 11.23 12 183209 161 79561006
Hypothermia 29.25 11.23 8 183213 22738 79538429
Skin exfoliation 29.25 11.23 51 183170 55049 79506118
Pain 29.17 11.23 1321 181900 702481 78858686
Peritonitis 29.05 11.23 14 183207 28022 79533145
Posterior reversible encephalopathy syndrome 29 11.23 12 183209 26269 79534898
Liver function test abnormal 29.00 11.23 250 182971 64225 79496942
Loss of personal independence in daily activities 28.97 11.23 129 183092 102451 79458716
Drug level increased 28.92 11.23 29 183192 39622 79521545
Dysarthria 28.79 11.23 71 183150 67551 79493616
Disseminated intravascular coagulation 28.77 11.23 24 183197 35818 79525349
Transplant rejection 28.72 11.23 5 183216 19432 79541735
Rehabilitation therapy 28.69 11.23 28 183193 1849 79559318
Cardiac index increased 28.66 11.23 8 183213 28 79561139
Dystonia 28.53 11.23 7 183214 21392 79539775
Torsade de pointes 28.46 11.23 5 183216 19307 79541860
Product supply issue 28.45 11.23 29 183192 2019 79559148
Jugular vein distension 28.42 11.23 25 183196 1445 79559722
Bronchopulmonary aspergillosis 28.37 11.23 8 183213 22286 79538881
Toxic skin eruption 28.37 11.23 8 183213 22285 79538882
Echocardiogram abnormal 28.17 11.23 30 183191 2198 79558969
Aspergillus infection 28.15 11.23 5 183216 19156 79542011
Orthostatic hypotension 28.02 11.23 54 183167 56110 79505057
Seasonal allergy 27.79 11.23 92 183129 16314 79544853
Upper respiratory tract infection 27.70 11.23 326 182895 90842 79470325
Hereditary haemorrhagic telangiectasia 27.63 11.23 8 183213 33 79561134
Seizure 27.50 11.23 289 182932 188545 79372622
Hepatic cytolysis 27.47 11.23 14 183207 27137 79534030
Left ventricular failure 27.40 11.23 65 183156 9516 79551651
Hospice care 27.34 11.23 68 183153 10256 79550911
Hypokalaemia 27.33 11.23 206 183015 143834 79417333
Muscular weakness 27.22 11.23 237 182984 160492 79400675
Hypoacusis 27.09 11.23 139 183082 30011 79531156
Blood lactate dehydrogenase increased 27.05 11.23 30 183191 39140 79522027
Proteinuria 27.04 11.23 21 183200 32481 79528686
Sleep study 26.96 11.23 7 183214 17 79561150
Infusion site inflammation 26.92 11.23 14 183207 333 79560834
Injection site discharge 26.75 11.23 19 183202 803 79560364
Candida infection 26.69 11.23 29 183192 38185 79522982
Infusion site vesicles 26.65 11.23 16 183205 506 79560661
Obstructive airways disorder 26.59 11.23 20 183201 31439 79529728
Osteopenia 26.53 11.23 5 183216 18359 79542808
Spinal cord infarction 26.50 11.23 17 183204 606 79560561
Device issue 26.50 11.23 128 183093 26980 79534187
Mineral supplementation 26.38 11.23 19 183202 821 79560346
Joint stiffness 26.34 11.23 33 183188 40797 79520370
Orthopnoea 26.31 11.23 66 183155 10007 79551160
Tracheostomy malfunction 26.23 11.23 11 183210 157 79561010
Nasopharyngitis 26.11 11.23 766 182455 253115 79308052
Transient global amnesia 26.03 11.23 20 183201 955 79560212
Blood calcium decreased 25.92 11.23 21 183200 31798 79529369
Joint range of motion decreased 25.85 11.23 23 183198 33259 79527908
Pre-existing condition improved 25.69 11.23 46 183175 5517 79555650
Pulmonary artery dilatation 25.58 11.23 15 183206 454 79560713
Aggression 25.41 11.23 49 183172 50909 79510258
Pleural effusion 25.39 11.23 472 182749 144790 79416377
Injury 25.33 11.23 92 183129 77404 79483763
CREST syndrome 25.29 11.23 15 183206 464 79560703
Diagnostic procedure 25.21 11.23 11 183210 174 79560993
Catheter site induration 25.17 11.23 8 183213 48 79561119
Cavopulmonary anastomosis 24.99 11.23 6 183215 9 79561158
Pemphigoid 24.80 11.23 3 183218 15312 79545855
Haemorrhage 24.74 11.23 319 182902 90799 79470368
Treatment noncompliance 24.74 11.23 205 183016 52063 79509104
Retinal vascular disorder 24.70 11.23 13 183208 317 79560850
Depression 24.66 11.23 350 182871 216440 79344727
Nocturnal dyspnoea 24.38 11.23 24 183197 1602 79559565
Haemodynamic test abnormal 24.37 11.23 8 183213 54 79561113
Injection site mass 24.32 11.23 8 183213 20176 79540991
Ammonia increased 24.26 11.23 54 183167 7581 79553586
Staphylococcus test positive 24.26 11.23 49 183172 6432 79554735
Suture insertion 24.23 11.23 13 183208 330 79560837
Product prescribing error 24.22 11.23 41 183180 44772 79516395
Colour blindness 24.11 11.23 14 183207 416 79560751
Exposure during pregnancy 24.08 11.23 135 183086 100997 79460170
Full blood count decreased 24.05 11.23 16 183205 26803 79534364
Blood iron decreased 23.91 11.23 84 183137 15350 79545817
Accidental exposure to product 23.90 11.23 22 183199 31300 79529867
Chest tube insertion 23.90 11.23 10 183211 142 79561025
Pulmonary capillary haemangiomatosis 23.76 11.23 8 183213 59 79561108
Catheter site mass 23.76 11.23 8 183213 59 79561108
Macrophages increased 23.72 11.23 12 183209 269 79560898
Rhinorrhoea 23.55 11.23 273 182948 75801 79485366
Penile curvature 23.28 11.23 6 183215 14 79561153
Sinusitis 23.17 11.23 313 182908 195188 79365979
Retinal artery occlusion 23.16 11.23 33 183188 3261 79557906
Hypoalbuminaemia 23.06 11.23 10 183211 21287 79539880
Coronary artery compression 23.05 11.23 5 183216 3 79561164
Anti factor VIII antibody test 23.05 11.23 5 183216 3 79561164
Choking sensation 22.99 11.23 36 183185 3870 79557297
Tenosynovitis 22.98 11.23 4 183217 15550 79545617
Parkinsonism 22.95 11.23 5 183216 16579 79544588
Retinal vein occlusion 22.94 11.23 33 183188 3290 79557877
Skin lesion 22.88 11.23 38 183183 41806 79519361
Labelled drug-drug interaction medication error 22.83 11.23 18 183203 27632 79533535
Chemotherapy 22.82 11.23 24 183197 1733 79559434
Second primary malignancy 22.78 11.23 3 183218 14347 79546820
Chromatopsia 22.72 11.23 16 183205 667 79560500
Diet noncompliance 22.72 11.23 15 183206 562 79560605
Diabetic ketoacidosis 22.63 11.23 27 183194 34095 79527072
Catheter site dryness 22.61 11.23 7 183214 38 79561129
Thrombotic microangiopathy 22.60 11.23 9 183212 20160 79541007
Head discomfort 22.53 11.23 79 183142 14423 79546744
Colitis ulcerative 22.50 11.23 28 183193 34714 79526453
Gastrointestinal tube insertion 22.49 11.23 23 183198 1607 79559560
Blood bilirubin increased 22.46 11.23 242 182979 65990 79495177
Tracheostomy tube removal 22.46 11.23 5 183216 4 79561163
Pulmonary arterial pressure decreased 22.29 11.23 9 183212 116 79561051
Cardiac arrest 22.22 11.23 535 182686 171561 79389606
Pulmonary valve replacement 22.19 11.23 6 183215 18 79561149
Therapeutic procedure 22.03 11.23 17 183204 817 79560350
Renal impairment 21.96 11.23 244 182977 157539 79403628
Heart sounds 21.90 11.23 18 183203 948 79560219
Self-medication 21.89 11.23 41 183180 5091 79556076
Tracheostomy infection 21.81 11.23 8 183213 78 79561089
Mouth ulceration 21.81 11.23 34 183187 38360 79522807
Spontaneous penile erection 21.75 11.23 9 183212 124 79561043
Product administration interrupted 21.66 11.23 35 183186 3864 79557303
Gastritis hypertrophic 21.61 11.23 7 183214 45 79561122
Infection 21.61 11.23 408 182813 241304 79319863
Tubulointerstitial nephritis 21.58 11.23 34 183187 38201 79522966
Exostosis 21.55 11.23 6 183215 16852 79544315
Choking 21.53 11.23 69 183152 12032 79549135
Device programming error 21.45 11.23 10 183211 186 79560981
Encephalitis 21.37 11.23 4 183217 14756 79546411
Vision blurred 21.33 11.23 352 182869 105546 79455621
Knee arthroplasty 21.21 11.23 42 183179 43206 79517961
Agitation 21.17 11.23 138 183083 99577 79461590
Night sweats 21.17 11.23 56 183165 52039 79509128
Cardiorenal syndrome 21.17 11.23 22 183199 1567 79559600
Atrial tachycardia 21.06 11.23 49 183172 7084 79554083
Oxygen consumption 21.03 11.23 8 183213 87 79561080
Obesity 21.02 11.23 30 183191 35095 79526072
Maculopathy 20.90 11.23 29 183192 2796 79558371
Pericardial drainage 20.87 11.23 13 183208 440 79560727
Acne 20.86 11.23 19 183202 27171 79533996
Diuretic therapy 20.84 11.23 10 183211 199 79560968
Device difficult to use 20.77 11.23 3 183218 13382 79547785
Ejaculation failure 20.77 11.23 12 183209 353 79560814
Transaminases increased 20.74 11.23 56 183165 51687 79509480
Tracheitis 20.66 11.23 20 183201 1308 79559859
Lip dry 20.64 11.23 5 183216 15413 79545754
Leukocytosis 20.63 11.23 43 183178 43412 79517755
Metastases to central nervous system 20.61 11.23 6 183215 16369 79544798
Metastases to lung 20.52 11.23 8 183213 18155 79543012
Akathisia 20.51 11.23 3 183218 13256 79547911
Congenital arterial malformation 20.49 11.23 6 183215 26 79561141
Cardiac flutter 20.41 11.23 39 183182 4915 79556252
Dysentery 20.41 11.23 19 183202 1183 79559984
Generalised oedema 20.40 11.23 108 183113 23601 79537566
Pneumothorax 20.39 11.23 123 183098 28200 79532967
Increased ventricular preload 20.31 11.23 4 183217 0 79561167
Body temperature increased 20.22 11.23 45 183176 44375 79516792
Nasal dryness 20.15 11.23 37 183184 4526 79556641
Delusion 19.97 11.23 11 183210 20412 79540755
Application site odour 19.95 11.23 6 183215 29 79561138
Hypogammaglobulinaemia 19.88 11.23 3 183218 12948 79548219
Male orgasmic disorder 19.87 11.23 7 183214 60 79561107
Wrong technique in product usage process 19.62 11.23 95 183126 73780 79487387
Catheter culture positive 19.57 11.23 10 183211 229 79560938
Pulmonary thrombosis 19.51 11.23 67 183154 12104 79549063
Immune reconstitution inflammatory syndrome 19.51 11.23 4 183217 13837 79547330
Hepatic function abnormal 19.42 11.23 94 183127 73013 79488154
Respiratory therapy 19.30 11.23 5 183216 12 79561155
Micrococcus test positive 19.30 11.23 5 183216 12 79561155
Arteriovenous malformation 19.30 11.23 22 183199 1739 79559428
Rash erythematous 19.26 11.23 68 183153 57701 79503466
Enterococcal infection 19.24 11.23 6 183215 15654 79545513
Bone disorder 19.12 11.23 10 183211 19103 79542064
Hypophosphataemia 19.08 11.23 11 183210 19902 79541265
Exercise test abnormal 19.01 11.23 7 183214 69 79561098
Enteritis 19.00 11.23 5 183216 14578 79546589
Nodule 18.95 11.23 15 183206 22979 79538188
Contusion 18.80 11.23 235 182986 148541 79412626
Hyperthermia 18.70 11.23 9 183212 18028 79543139
Decreased activity 18.70 11.23 53 183168 8641 79552526
Herpes zoster 18.68 11.23 131 183090 92952 79468215
Respiratory disorder 18.66 11.23 171 183050 44685 79516482
Ataxia 18.62 11.23 18 183203 25021 79536146
Blood alkaline phosphatase increased 18.61 11.23 226 182995 63438 79497729
Haematuria 18.58 11.23 88 183133 68748 79492419
Tricuspid valve incompetence 18.50 11.23 92 183129 19620 79541547
Spontaneous intrahepatic portosystemic venous shunt 18.49 11.23 5 183216 15 79561152
Angioedema 18.37 11.23 101 183120 75934 79485233
Multiple organ dysfunction syndrome 18.34 11.23 182 183039 120064 79441103
Ammonia abnormal 18.32 11.23 9 183212 189 79560978
Paranasal sinus discomfort 18.26 11.23 35 183186 4421 79556746
Cardiac output increased 18.22 11.23 10 183211 266 79560901
Fibrinous bronchitis 18.21 11.23 6 183215 41 79561126
Expired product administered 18.21 11.23 46 183175 7005 79554162
Immunodeficiency 18.19 11.23 14 183207 21754 79539413
Pancreatitis acute 18.19 11.23 56 183165 49548 79511619
Ileus 18.18 11.23 20 183201 26191 79534976
Abnormal behaviour 18.18 11.23 35 183186 36386 79524781
Weight increased 18.14 11.23 795 182426 276591 79284576
Psychomotor hyperactivity 18.10 11.23 8 183213 16841 79544326
Bronchiectasis 17.95 11.23 15 183206 22371 79538796
Therapeutic response shortened 17.90 11.23 7 183214 15856 79545311
Peripheral sensory neuropathy 17.89 11.23 4 183217 13029 79548138
Blindness 17.80 11.23 119 183102 28264 79532903
Drug tolerance decreased 17.79 11.23 4 183217 12974 79548193
Biopsy bone marrow 17.77 11.23 11 183210 368 79560799
Ear tube insertion 17.76 11.23 8 183213 137 79561030
Miosis 17.76 11.23 7 183214 15782 79545385
Infusion site discolouration 17.75 11.23 14 183207 695 79560472
Muscle spasticity 17.71 11.23 14 183207 21461 79539706
Disorientation 17.69 11.23 79 183142 62697 79498470
Prolonged expiration 17.66 11.23 18 183203 1253 79559914
Infective pulmonary exacerbation of cystic fibrosis 17.53 11.23 4 183217 12847 79548320
Colonoscopy 17.52 11.23 22 183199 1925 79559242
Injection site haemorrhage 17.49 11.23 23 183198 27847 79533320
Injection site urticaria 17.48 11.23 4 183217 12822 79548345
Sleep disorder 17.47 11.23 120 183101 85557 79475610
Cytomegalovirus viraemia 17.47 11.23 4 183217 12817 79548350
Viral upper respiratory tract infection 17.47 11.23 53 183168 8973 79552194
Catheter site abscess 17.40 11.23 6 183215 48 79561119
Oral pain 17.27 11.23 29 183192 31769 79529398
Haematotoxicity 17.26 11.23 7 183214 15512 79545655
Ear discomfort 17.18 11.23 51 183170 8532 79552635
Large intestine perforation 17.16 11.23 6 183215 14561 79546606
Thunderclap headache 17.10 11.23 11 183210 394 79560773
Ventricular assist device insertion 17.08 11.23 6 183215 51 79561116
Purpura 17.04 11.23 12 183209 19515 79541652
Product storage error 16.97 11.23 8 183213 16218 79544949
Speech disorder 16.90 11.23 66 183155 54379 79506788
Mitral valve replacement 16.88 11.23 11 183210 403 79560764
Drug level decreased 16.85 11.23 6 183215 14396 79546771
Hypoglossal nerve paralysis 16.83 11.23 5 183216 23 79561144
Phlebotomy 16.75 11.23 7 183214 99 79561068
Middle ear effusion 16.70 11.23 24 183197 2391 79558776
Erythema 16.69 11.23 388 182833 222902 79338265
Restlessness 16.68 11.23 53 183168 46439 79514728
Visual brightness 16.68 11.23 6 183215 55 79561112
Tuberculosis 16.67 11.23 7 183214 15191 79545976
Blindness transient 16.57 11.23 35 183186 4741 79556426
Hypertensive crisis 16.56 11.23 14 183207 20756 79540411
Cardiac failure high output 16.55 11.23 10 183211 320 79560847
Catheter site dermatitis 16.50 11.23 7 183214 103 79561064
Ejaculation disorder 16.49 11.23 12 183209 527 79560640
Skin operation 16.49 11.23 5 183216 25 79561142
Heart valve replacement 16.45 11.23 15 183206 909 79560258
Hallucination, auditory 16.43 11.23 14 183207 20679 79540488
Portopulmonary hypertension 16.41 11.23 8 183213 165 79561002
Right atrial dilatation 16.40 11.23 14 183207 777 79560390
Adrenal insufficiency 16.40 11.23 25 183196 28462 79532705
Biopsy kidney 16.33 11.23 8 183213 167 79561000
Catheter site hypersensitivity 16.32 11.23 7 183214 106 79561061
Large intestinal polypectomy 16.28 11.23 10 183211 330 79560837
Septic shock 16.26 11.23 192 183029 122609 79438558
Polyarthritis 16.25 11.23 4 183217 12198 79548969
Herpes simplex 16.22 11.23 4 183217 12183 79548984
Hydronephrosis 16.22 11.23 10 183211 17444 79543723
Needle issue 16.06 11.23 5 183216 13063 79548104
Product contamination 15.99 11.23 17 183204 1243 79559924
Throat irritation 15.98 11.23 154 183067 40792 79520375
Glare 15.97 11.23 7 183214 112 79561055
Pyelonephritis 15.94 11.23 14 183207 20374 79540793
Cardiac failure chronic 15.89 11.23 59 183162 11076 79550091
Catheter site erosion 15.79 11.23 6 183215 65 79561102
Injection site rash 15.71 11.23 11 183210 17943 79543224
Optic disc disorder 15.70 11.23 7 183214 117 79561050
Sinus bradycardia 15.67 11.23 21 183200 25226 79535941
Eating disorder symptom 15.63 11.23 6 183215 67 79561100
Dry eye 15.54 11.23 39 183182 36892 79524275
Sudden cardiac death 15.54 11.23 36 183185 5189 79555978
Pulmonary haemorrhage 15.49 11.23 71 183150 14646 79546521
Pulmonary artery therapeutic procedure 15.46 11.23 5 183216 32 79561135
Hypertriglyceridaemia 15.44 11.23 5 183216 12735 79548432
Drug titration error 15.32 11.23 16 183205 1146 79560021
Hip fracture 15.28 11.23 122 183099 30639 79530528
Adenotonsillectomy 15.25 11.23 6 183215 72 79561095
Radiotherapy 15.24 11.23 12 183209 594 79560573
Breast tumour excision 15.24 11.23 3 183218 0 79561167
Orchidopexy 15.24 11.23 3 183218 0 79561167
Exposure to chemical pollution 15.24 11.23 3 183218 0 79561167
Primary headache associated with sexual activity 15.24 11.23 3 183218 0 79561167
Pharyngeal injury 15.24 11.23 3 183218 0 79561167
Chronic hepatic failure 15.20 11.23 15 183206 1004 79560163
Osteomyelitis 15.20 11.23 33 183188 32832 79528335
Fistula repair 15.17 11.23 6 183215 73 79561094
Rales 15.13 11.23 88 183133 19913 79541254
Human metapneumovirus test positive 15.13 11.23 8 183213 197 79560970
Blood pressure diastolic decreased 15.11 11.23 29 183192 30187 79530980
Supraventricular tachycardia 15.08 11.23 92 183129 21178 79539989
Aortic valve repair 15.05 11.23 4 183217 11 79561156
COVID-19 pneumonia 15.04 11.23 27 183194 28822 79532345
Thoracic cavity drainage 15.01 11.23 9 183212 284 79560883
Application site erythema 14.97 11.23 35 183186 5075 79556092
Oesophageal dilation procedure 14.95 11.23 6 183215 76 79561091
Biopsy 14.93 11.23 13 183208 741 79560426
Urinary retention 14.93 11.23 73 183148 56557 79504610
Bone density decreased 14.88 11.23 6 183215 13341 79547826
Protein-losing gastroenteropathy 14.83 11.23 12 183209 618 79560549
Blood carbon monoxide increased 14.80 11.23 4 183217 12 79561155
Gastrointestinal surgery 14.79 11.23 9 183212 292 79560875
Skin irritation 14.76 11.23 58 183163 11182 79549985
Urinary tract infection 14.64 11.23 500 182721 274012 79287155
Pulmonary pain 14.62 11.23 32 183189 4441 79556726
Tendonitis 14.61 11.23 20 183201 23810 79537357
Adverse drug reaction 14.54 11.23 91 183130 66301 79494866
Iron deficiency anaemia 14.54 11.23 105 183116 25567 79535600
Generalised tonic-clonic seizure 14.43 11.23 52 183169 43858 79517309
Thyroidectomy 14.30 11.23 14 183207 928 79560239
Penile swelling 14.25 11.23 12 183209 654 79560513
Metapneumovirus infection 14.24 11.23 19 183202 1765 79559402
Drain placement 14.21 11.23 7 183214 148 79561019
Cardiopulmonary failure 14.18 11.23 41 183180 6760 79554407
Purulent discharge 14.16 11.23 38 183183 6001 79555166
Oesophagogastric fundoplasty 14.12 11.23 7 183214 150 79561017
Withdrawal syndrome 14.12 11.23 25 183196 26829 79534338
Catheter site scar 14.12 11.23 4 183217 15 79561152
Extra dose administered 14.09 11.23 47 183174 8368 79552799
Hyperammonaemia 14.08 11.23 4 183217 11089 79550078
Right ventricular systolic pressure decreased 14.04 11.23 6 183215 90 79561077
Emotional distress 14.04 11.23 46 183175 39923 79521244
Blood glucose increased 14.01 11.23 183 183038 114792 79446375
Pulseless electrical activity 13.94 11.23 67 183154 14093 79547074
Wound infection 13.86 11.23 21 183200 23970 79537197
Blood ethanol increased 13.83 11.23 12 183209 681 79560486
Osteonecrosis 13.75 11.23 32 183189 31063 79530104
Infusion site nodule 13.73 11.23 9 183212 333 79560834
Administration site infection 13.72 11.23 4 183217 17 79561150
Balance disorder 13.70 11.23 153 183068 98704 79462463
Sudden visual loss 13.70 11.23 5 183216 48 79561119
Impaired work ability 13.67 11.23 15 183206 19666 79541501
Bronchopulmonary dysplasia 13.62 11.23 8 183213 243 79560924
Critical illness 13.61 11.23 9 183212 338 79560829
Cataract operation 13.57 11.23 34 183187 5151 79556016
Catheter site bruise 13.57 11.23 10 183211 448 79560719
Food allergy 13.56 11.23 4 183217 10820 79550347
Upper limb fracture 13.56 11.23 79 183142 17888 79543279
Therapy partial responder 13.53 11.23 12 183209 17385 79543782
Life support 13.51 11.23 10 183211 451 79560716
Clubbing 13.51 11.23 12 183209 703 79560464
Skin necrosis 13.45 11.23 13 183208 18074 79543093
Status epilepticus 13.45 11.23 23 183198 25018 79536149
Central nervous system lesion 13.36 11.23 7 183214 13361 79547806
Gait inability 13.30 11.23 80 183141 58837 79502330
Immunoglobulin G4 related disease 13.19 11.23 8 183213 258 79560909
Suture rupture 13.18 11.23 11 183210 592 79560575
Fasciectomy 13.16 11.23 3 183218 3 79561164
Cell-free and concentrated ascites reinfusion therapy 13.16 11.23 3 183218 3 79561164
Biopsy colon 13.16 11.23 3 183218 3 79561164
Musculoskeletal disorder 13.15 11.23 18 183203 21430 79539737
Atrial septal defect 13.14 11.23 19 183202 1903 79559264
Intra-abdominal fluid collection 13.11 11.23 25 183196 3147 79558020
Catheter site cellulitis 13.10 11.23 10 183211 473 79560694
Bronchitis 13.09 11.23 393 182828 130251 79430916
Disability 13.09 11.23 12 183209 17108 79544059
Deformity 13.08 11.23 3 183218 9602 79551565
Injection site warmth 13.06 11.23 9 183212 14798 79546369
Hepatic cirrhosis 13.00 11.23 130 183091 34776 79526391
Limb operation 12.94 11.23 26 183195 3400 79557767
Leg amputation 12.88 11.23 27 183194 3639 79557528
Poisoning 12.86 11.23 24 183197 25248 79535919
Hypophagia 12.84 11.23 57 183164 45310 79515857
Respiratory tract irritation 12.83 11.23 11 183210 614 79560553
Dilatation ventricular 12.82 11.23 29 183192 4115 79557052
Endarterectomy 12.81 11.23 9 183212 374 79560793
Rash pustular 12.75 11.23 5 183216 11306 79549861
Myasthenia gravis 12.75 11.23 4 183217 10395 79550772
Metastases to lymph nodes 12.74 11.23 4 183217 10393 79550774
Vertebral artery stenosis 12.72 11.23 7 183214 187 79560980
Lymphadenopathy 12.72 11.23 71 183150 53176 79507991
Atrioventricular septal defect 12.71 11.23 6 183215 115 79561052
Annuloplasty 12.70 11.23 3 183218 4 79561163
Jaundice cholestatic 12.70 11.23 5 183216 11279 79549888
Vasculitis 12.64 11.23 24 183197 25078 79536089
Infusion site reaction 12.59 11.23 26 183195 3467 79557700
Pneumonia aspiration 12.59 11.23 96 183125 66871 79494296
Myocarditis 12.58 11.23 19 183202 21714 79539453
Platelet count increased 12.57 11.23 20 183201 22386 79538781
Aspartate aminotransferase increased 12.56 11.23 412 182809 138229 79422938
Enterocolitis 12.56 11.23 9 183212 14503 79546664
Renal tubular necrosis 12.55 11.23 24 183197 25015 79536152
Acute hepatic failure 12.52 11.23 32 183189 30081 79531086
Bedridden 12.51 11.23 58 183163 12021 79549146
Epstein-Barr virus antibody positive 12.50 11.23 11 183210 636 79560531
Hypercapnia 12.46 11.23 47 183174 8888 79552279
Fall 12.46 11.23 1291 181930 486338 79074829
Nervous system disorder 12.39 11.23 27 183194 26829 79534338
Oesophageal carcinoma 12.33 11.23 5 183216 11079 79550088
Cardiac discomfort 12.31 11.23 15 183206 1273 79559894
Hysterectomy 12.30 11.23 37 183184 6235 79554932
Respiratory tract infection viral 12.29 11.23 29 183192 4230 79556937
Gastric antral vascular ectasia 12.29 11.23 13 183208 945 79560222
Executive dysfunction 12.28 11.23 8 183213 293 79560874
Sickle cell anaemia 12.26 11.23 11 183210 653 79560514
Multiple allergies 12.17 11.23 52 183169 10408 79550759
Localised infection 12.14 11.23 136 183085 37439 79523728
Implant site extravasation 12.12 11.23 12 183209 807 79560360
Dermatitis bullous 12.11 11.23 9 183212 14236 79546931
Cholecystitis acute 12.10 11.23 8 183213 13443 79547724
Cardiothoracic ratio increased 12.08 11.23 5 183216 69 79561098
Echocardiogram 12.06 11.23 4 183217 28 79561139
Cardiac index decreased 12.04 11.23 6 183215 130 79561037
Suture related complication 12.04 11.23 8 183213 303 79560864
Ejection fraction decreased 12.00 11.23 40 183181 34537 79526630
Disturbance in attention 11.99 11.23 68 183153 50733 79510434
Secretion discharge 11.96 11.23 67 183154 14955 79546212
Intestinal adhesion lysis 11.95 11.23 3 183218 6 79561161
Immunosuppressant drug level increased 11.94 11.23 3 183218 9024 79552143
Oesophageal variceal ligation 11.88 11.23 6 183215 134 79561033
Dermatitis exfoliative 11.86 11.23 5 183216 10824 79550343
Exposure to fungus 11.84 11.23 6 183215 135 79561032
Insulin autoimmune syndrome 11.84 11.23 9 183212 423 79560744
Atrioventricular block first degree 11.82 11.23 7 183214 12484 79548683
Guillain-Barre syndrome 11.82 11.23 3 183218 8962 79552205
Implantable defibrillator insertion 11.72 11.23 13 183208 997 79560170
Macular detachment 11.70 11.23 7 183214 220 79560947
Application site rash 11.65 11.23 19 183202 2113 79559054
Renal injury 11.65 11.23 13 183208 16914 79544253
Jejunostomy 11.64 11.23 5 183216 76 79561091
Arterial aneurysm repair 11.64 11.23 3 183218 7 79561160
Investigation 11.58 11.23 20 183201 2331 79558836
Collateral circulation 11.58 11.23 5 183216 77 79561090
Oesophagitis 11.56 11.23 24 183197 24265 79536902
Monocyte count increased 11.55 11.23 5 183216 10656 79550511
Drug level below therapeutic 11.55 11.23 4 183217 9766 79551401
Catheter site urticaria 11.49 11.23 4 183217 33 79561134
Polypectomy 11.47 11.23 14 183207 1190 79559977
Breast cancer female 11.46 11.23 6 183215 11455 79549712
Mixed connective tissue disease 11.46 11.23 8 183213 329 79560838
Vena cava filter insertion 11.45 11.23 6 183215 145 79561022
Infusion site discomfort 11.42 11.23 15 183206 1372 79559795
Subdural haematoma evacuation 11.41 11.23 5 183216 80 79561087
Arrhythmia 11.37 11.23 201 183020 61071 79500096
Low cardiac output syndrome 11.36 11.23 13 183208 1032 79560135
Liver ablation 11.36 11.23 3 183218 8 79561159
Flatulence 11.35 11.23 149 183072 42575 79518592
Intestinal perforation 11.33 11.23 14 183207 17412 79543755
Ileus paralytic 11.27 11.23 4 183217 9616 79551551

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC G04BE03 GENITO URINARY SYSTEM AND SEX HORMONES
UROLOGICALS
UROLOGICALS
Drugs used in erectile dysfunction
FDA MoA N0000020026 Phosphodiesterase 5 Inhibitors
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D058986 Phosphodiesterase 5 Inhibitors
MeSH PA D010726 Phosphodiesterase Inhibitors
MeSH PA D064804 Urological Agents
MeSH PA D014665 Vasodilator Agents
CHEBI has role CHEBI:35620 vasodilator agents
CHEBI has role CHEBI:71942 PDE5 inhibitor
FDA EPC N0000175599 Phosphodiesterase 5 Inhibitor

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Pulmonary arterial hypertension indication 11399002
Impotence indication 397803000
Induratio penis plastica contraindication 1335005 DOID:8616
Priapism contraindication 6273006 DOID:9286
Hearing loss contraindication 15188001
Myocardial infarction contraindication 22298006 DOID:5844
Fibrosis of corpus cavernosum contraindication 32608004
Dehydration contraindication 34095006
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Aortic valve stenosis contraindication 60573004 DOID:1712
Pulmonary veno-occlusive disease contraindication 89420002 DOID:5453
Leukemia, disease contraindication 93143009 DOID:1240
Multiple myeloma contraindication 109989006 DOID:9538
Hb SS disease contraindication 127040003 DOID:10923
Cerebrovascular accident contraindication 230690007
Penis bent contraindication 249247007
Esophageal dysmotility contraindication 266434009 DOID:9192
Idiopathic hypertrophic subaortic stenosis contraindication 360465008
Acute coronary syndrome contraindication 394659003
Anterior ischemic optic neuropathy contraindication 404659001
Hypertensive urgency contraindication 443482000
Pigmentary Retinopathy contraindication
Severe Autonomic Insufficiency contraindication
Hereditary Degeneration of Retina contraindication
Life-Threatening Cardiac Arrhythmias contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.35 acidic
pKa2 7.72 Basic
pKa3 3.61 Basic
pKa4 2.92 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 10MG BASE/ML LIQREV CMP DEV LLC N214952 April 28, 2023 RX SUSPENSION ORAL 11337979 Dec. 24, 2038 LIQREV IS INDICATED FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION (WHO GROUP 1) IN ADULTS TO IMPROVE EXERCISE ABILITY AND DELAY CLINICAL WORSENING
EQ 10MG BASE/ML LIQREV CMP DEV LLC N214952 April 28, 2023 RX SUSPENSION ORAL 11464778 Dec. 24, 2038 LIQREV IS INDICATED FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION (WHO GROUP 1) IN ADULTS TO IMPROVE EXERCISE ABILITY AND DELAY CLINICAL WORSENING

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 20MG BASE REVATIO VIATRIS N021845 June 3, 2005 RX TABLET ORAL Jan. 31, 2026 LABELING REGARDING NEW DOSING REGIMEN IN ADULTS WITH PULMONARY ARTERIAL HYPERTENSION (PAH) AND TREATMENT OF PAH IN PEDIATRIC PATIENTS (AGES 1-17)
EQ 10MG BASE/12.5ML (EQ 0.8MG BASE/ML) REVATIO VIATRIS N022473 Nov. 18, 2009 RX SOLUTION INTRAVENOUS Jan. 31, 2026 LABELING REGARDING NEW DOSING REGIMEN IN ADULTS WITH PULMONARY ARTERIAL HYPERTENSION (PAH) AND TREATMENT OF PAH IN PEDIATRIC PATIENTS (AGES 1-17)
EQ 10MG BASE/ML REVATIO VIATRIS N203109 Aug. 30, 2012 RX FOR SUSPENSION ORAL Jan. 31, 2026 LABELING REGARDING NEW DOSING REGIMEN IN ADULTS WITH PULMONARY ARTERIAL HYPERTENSION (PAH) AND TREATMENT OF PAH IN PEDIATRIC PATIENTS (AGES 1-17)

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
cGMP-specific 3',5'-cyclic phosphodiesterase Enzyme INHIBITOR IC50 9 IUPHAR CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.48 CHEMBL
Adenosine receptor A1 GPCR Ki 6.06 DRUG MATRIX
Multidrug resistance-associated protein 5 Transporter Ki 5.92 CHEMBL
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha Enzyme WOMBAT-PK
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A Enzyme IC50 5.64 CHEMBL
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Enzyme IC50 5.51 CHEMBL
cAMP-specific 3',5'-cyclic phosphodiesterase 4D Enzyme IC50 4.70 CHEMBL
cGMP-dependent 3',5'-cyclic phosphodiesterase Enzyme IC50 4.20 CHEMBL
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A Enzyme IC50 5.33 CHEMBL
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' Enzyme IC50 7.41 CHEMBL
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Enzyme IC50 5.47 CHEMBL
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A Enzyme IC50 4 CHEMBL
Phosphodiesterase 3 Enzyme IC50 5.15 CHEMBL
Phosphodiesterase 4 Enzyme IC50 5.11 CHEMBL
Phosphodiesterase 1 Enzyme IC50 6.57 CHEMBL
Solute carrier organic anion transporter family member 1B3 Transporter INHIBITOR IC50 6.10 IUPHAR
Adenosine receptor A2a GPCR Ki 6.70 CHEMBL
Alpha-1B adrenergic receptor GPCR Ki 6.09 DRUG MATRIX
cGMP-specific 3',5'-cyclic phosphodiesterase Enzyme Ki 8.74 CHEMBL
Uncharacterized protein Enzyme IC50 5.04 CHEMBL
cGMP-specific 3',5'-cyclic phosphodiesterase Enzyme IC50 8.22 CHEMBL
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' Enzyme IC50 7.48 CHEMBL
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha Enzyme IC50 6.85 CHEMBL
Indoleamine 2,3-dioxygenase 2 Enzyme IC50 5.35 CHEMBL
cGMP-specific 3',5'-cyclic phosphodiesterase Enzyme IC50 9 CHEMBL
Phosphodiesterase 4 Enzyme IC50 5.34 CHEMBL
Phosphodiesterase 1 Enzyme IC50 6.40 CHEMBL
Phosphodiesterase 6 Enzyme IC50 7.70 CHEMBL
Phosphodiesterase 1 Enzyme IC50 6.59 CHEMBL
Phosphodiesterase 2A Enzyme IC50 4.37 CHEMBL

External reference:

IDSource
4024110 VUID
N0000022115 NUI
D02229 KEGG_DRUG
171599-83-0 SECONDARY_CAS_RN
4021093 VANDF
4024110 VANDF
C1318700 UMLSCUI
CHEBI:9139 CHEBI
VIA PDB_CHEM_ID
CHEMBL192 ChEMBL_ID
CHEMBL1737 ChEMBL_ID
D000068677 MESH_DESCRIPTOR_UI
DB00203 DRUGBANK_ID
4743 IUPHAR_LIGAND_ID
7374 INN_ID
3M7OB98Y7H UNII
135398744 PUBCHEM_CID
136411 RXNORM
147641 MMSL
194438 MMSL
26866 MMSL
29679 MMSL
5460 MMSL
69683 MMSL
d04299 MMSL
007448 NDDF
007449 NDDF
108482004 SNOMEDCT_US
109123009 SNOMEDCT_US
372572000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Revatio HUMAN PRESCRIPTION DRUG LABEL 1 0069-0336 POWDER, FOR SUSPENSION 10 mg ORAL NDA 32 sections
Revatio HUMAN PRESCRIPTION DRUG LABEL 1 0069-0336 POWDER, FOR SUSPENSION 10 mg ORAL NDA 32 sections
Revatio HUMAN PRESCRIPTION DRUG LABEL 1 0069-0338 INJECTION, SOLUTION 0.80 mg INTRAVENOUS NDA 32 sections
Revatio HUMAN PRESCRIPTION DRUG LABEL 1 0069-0338 INJECTION, SOLUTION 0.80 mg INTRAVENOUS NDA 32 sections
Revatio HUMAN PRESCRIPTION DRUG LABEL 1 0069-4190 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Revatio HUMAN PRESCRIPTION DRUG LABEL 1 0069-4190 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Viagra HUMAN PRESCRIPTION DRUG LABEL 1 0069-4200 TABLET, FILM COATED 25 mg ORAL NDA 28 sections
Viagra HUMAN PRESCRIPTION DRUG LABEL 1 0069-4200 TABLET, FILM COATED 25 mg ORAL NDA 28 sections
Viagra HUMAN PRESCRIPTION DRUG LABEL 1 0069-4210 TABLET, FILM COATED 50 mg ORAL NDA 28 sections
Viagra HUMAN PRESCRIPTION DRUG LABEL 1 0069-4210 TABLET, FILM COATED 50 mg ORAL NDA 28 sections
Viagra HUMAN PRESCRIPTION DRUG LABEL 1 0069-4220 TABLET, FILM COATED 100 mg ORAL NDA 28 sections
Viagra HUMAN PRESCRIPTION DRUG LABEL 1 0069-4220 TABLET, FILM COATED 100 mg ORAL NDA 28 sections
Sildenafil HUMAN PRESCRIPTION DRUG LABEL 1 0093-5341 TABLET, FILM COATED 25 mg ORAL ANDA 26 sections
Sildenafil HUMAN PRESCRIPTION DRUG LABEL 1 0093-5341 TABLET, FILM COATED 25 mg ORAL ANDA 26 sections
Sildenafil HUMAN PRESCRIPTION DRUG LABEL 1 0093-5341 TABLET, FILM COATED 25 mg ORAL ANDA 26 sections
Sildenafil HUMAN PRESCRIPTION DRUG LABEL 1 0093-5342 TABLET, FILM COATED 50 mg ORAL ANDA 26 sections
Sildenafil HUMAN PRESCRIPTION DRUG LABEL 1 0093-5342 TABLET, FILM COATED 50 mg ORAL ANDA 26 sections
Sildenafil HUMAN PRESCRIPTION DRUG LABEL 1 0093-5342 TABLET, FILM COATED 50 mg ORAL ANDA 26 sections
Sildenafil HUMAN PRESCRIPTION DRUG LABEL 1 0093-5343 TABLET, FILM COATED 100 mg ORAL ANDA 26 sections
Sildenafil HUMAN PRESCRIPTION DRUG LABEL 1 0093-5343 TABLET, FILM COATED 100 mg ORAL ANDA 26 sections
Sildenafil HUMAN PRESCRIPTION DRUG LABEL 1 0093-5343 TABLET, FILM COATED 100 mg ORAL ANDA 26 sections
Sildenafil HUMAN PRESCRIPTION DRUG LABEL 1 0093-5517 TABLET, FILM COATED 20 mg ORAL ANDA 26 sections
Sildenafil HUMAN PRESCRIPTION DRUG LABEL 1 0093-5517 TABLET, FILM COATED 20 mg ORAL ANDA 26 sections
Sildenafil HUMAN PRESCRIPTION DRUG LABEL 1 0093-5517 TABLET, FILM COATED 20 mg ORAL ANDA 26 sections
Sildenafil HUMAN PRESCRIPTION DRUG LABEL 1 0378-1657 TABLET, FILM COATED 20 mg ORAL ANDA 30 sections
Sildenafil HUMAN PRESCRIPTION DRUG LABEL 1 0378-1657 TABLET, FILM COATED 20 mg ORAL ANDA 30 sections
Sildenafil HUMAN PRESCRIPTION DRUG LABEL 1 0378-1658 TABLET, FILM COATED 25 mg ORAL ANDA 29 sections
Sildenafil HUMAN PRESCRIPTION DRUG LABEL 1 0378-1659 TABLET, FILM COATED 50 mg ORAL ANDA 29 sections
Sildenafil HUMAN PRESCRIPTION DRUG LABEL 1 0378-1660 TABLET, FILM COATED 100 mg ORAL ANDA 29 sections
Sildenafil HUMAN PRESCRIPTION DRUG LABEL 1 0591-4050 POWDER, FOR SUSPENSION 10 mg ORAL ANDA 26 sections