Stem definition | Drug id | CAS RN |
---|---|---|
inhibitors of phosphodiesterase PDE5 with vasodilator action | 2441 | 139755-83-2 |
Dose | Unit | Route |
---|---|---|
50 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 3.50 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 7.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 3.52 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 38 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 1.36 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 9 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.04 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 2.20 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
March 27, 1998 | FDA | PFIZER IRELAND |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Pulmonary arterial hypertension | 2634.97 | 12.96 | 1181 | 120490 | 19138 | 50464315 |
Dyspnoea | 2194.12 | 12.96 | 4342 | 117329 | 543266 | 49940187 |
Fluid retention | 1799.62 | 12.96 | 1255 | 120416 | 49394 | 50434059 |
Right ventricular failure | 1692.08 | 12.96 | 806 | 120865 | 15087 | 50468366 |
Pulmonary hypertension | 1507.40 | 12.96 | 961 | 120710 | 32456 | 50450997 |
Death | 1352.88 | 12.96 | 2628 | 119043 | 322751 | 50160702 |
Pain in jaw | 1331.34 | 12.96 | 938 | 120733 | 37490 | 50445963 |
Hypervolaemia | 935.62 | 12.96 | 645 | 121026 | 24854 | 50458599 |
Dyspnoea exertional | 878.69 | 12.96 | 830 | 120841 | 50403 | 50433050 |
Drug ineffective | 808.69 | 12.96 | 489 | 121182 | 818844 | 49664609 |
Headache | 693.69 | 12.96 | 2721 | 118950 | 503814 | 49979639 |
Catheter site erythema | 669.68 | 12.96 | 278 | 121393 | 3684 | 50479769 |
Oxygen saturation decreased | 553.92 | 12.96 | 777 | 120894 | 72471 | 50410982 |
Nasal congestion | 541.68 | 12.96 | 641 | 121030 | 50479 | 50432974 |
Lung transplant | 538.23 | 12.96 | 216 | 121455 | 2609 | 50480844 |
Transfusion | 519.83 | 12.96 | 346 | 121325 | 12559 | 50470894 |
Oedema | 513.68 | 12.96 | 733 | 120938 | 69448 | 50414005 |
Hospitalisation | 506.73 | 12.96 | 716 | 120955 | 67221 | 50416232 |
Flushing | 500.90 | 12.96 | 707 | 120964 | 66308 | 50417145 |
Device related infection | 481.22 | 12.96 | 399 | 121272 | 20336 | 50463117 |
Catheter site pruritus | 456.45 | 12.96 | 174 | 121497 | 1813 | 50481640 |
Catheter site pain | 443.97 | 12.96 | 205 | 121466 | 3557 | 50479896 |
Catheter management | 442.12 | 12.96 | 186 | 121485 | 2553 | 50480900 |
Infusion site pain | 410.11 | 12.96 | 294 | 121377 | 12052 | 50471401 |
Hypoxia | 378.43 | 12.96 | 537 | 121134 | 50586 | 50432867 |
Chest pain | 375.38 | 12.96 | 1103 | 120568 | 175779 | 50307674 |
Pulmonary arterial pressure increased | 356.69 | 12.96 | 170 | 121501 | 3178 | 50480275 |
Alopecia | 354.53 | 12.96 | 78 | 121593 | 244969 | 50238484 |
Infusion related reaction | 354.01 | 12.96 | 12 | 121659 | 169545 | 50313908 |
Cardiac failure | 348.09 | 12.96 | 642 | 121029 | 75398 | 50408055 |
Catheter site discharge | 346.10 | 12.96 | 140 | 121531 | 1728 | 50481725 |
Oedema peripheral | 335.99 | 12.96 | 986 | 120685 | 156975 | 50326478 |
Toxicity to various agents | 331.96 | 12.96 | 56 | 121615 | 212443 | 50271010 |
Syncope | 318.68 | 12.96 | 740 | 120931 | 102262 | 50381191 |
Catheterisation cardiac | 315.00 | 12.96 | 166 | 121505 | 3874 | 50479579 |
Catheter site infection | 314.15 | 12.96 | 169 | 121502 | 4117 | 50479336 |
Pulmonary oedema | 300.47 | 12.96 | 471 | 121200 | 48467 | 50434986 |
Contraindicated product administered | 296.04 | 12.96 | 15 | 121656 | 148943 | 50334510 |
Cough | 290.83 | 12.96 | 1249 | 120422 | 240015 | 50243438 |
Rheumatoid arthritis | 283.88 | 12.96 | 69 | 121602 | 202481 | 50280972 |
Drug hypersensitivity | 281.07 | 12.96 | 126 | 121545 | 250884 | 50232569 |
Neutropenia | 270.22 | 12.96 | 23 | 121648 | 147942 | 50335511 |
Treatment failure | 269.93 | 12.96 | 15 | 121656 | 137622 | 50345831 |
Oxygen consumption increased | 269.21 | 12.96 | 143 | 121528 | 3393 | 50480060 |
Pneumonia | 265.75 | 12.96 | 1685 | 119986 | 376716 | 50106737 |
Rash | 264.91 | 12.96 | 402 | 121269 | 437069 | 50046384 |
Completed suicide | 262.96 | 12.96 | 13 | 121658 | 131876 | 50351577 |
Infusion site erythema | 251.94 | 12.96 | 191 | 121480 | 8536 | 50474917 |
Central venous catheterisation | 244.89 | 12.96 | 114 | 121557 | 2016 | 50481437 |
Respiratory failure | 237.19 | 12.96 | 613 | 121058 | 90568 | 50392885 |
Scleroderma | 236.10 | 12.96 | 146 | 121525 | 4655 | 50478798 |
Joint swelling | 235.19 | 12.96 | 150 | 121521 | 245136 | 50238317 |
Glossodynia | 234.92 | 12.96 | 10 | 121661 | 115559 | 50367894 |
Palpitations | 229.20 | 12.96 | 619 | 121052 | 93887 | 50389566 |
Catheter site swelling | 226.08 | 12.96 | 94 | 121577 | 1250 | 50482203 |
Cardiac failure congestive | 223.29 | 12.96 | 571 | 121100 | 83811 | 50399642 |
Device alarm issue | 216.50 | 12.96 | 92 | 121579 | 1296 | 50482157 |
Therapeutic product effect decreased | 216.49 | 12.96 | 34 | 121637 | 136016 | 50347437 |
Device leakage | 216.17 | 12.96 | 149 | 121522 | 5729 | 50477724 |
Catheter placement | 213.25 | 12.96 | 102 | 121569 | 1922 | 50481531 |
Hypotension | 212.89 | 12.96 | 1122 | 120549 | 234347 | 50249106 |
Arthropathy | 211.24 | 12.96 | 59 | 121612 | 157847 | 50325606 |
Catheter site haemorrhage | 200.92 | 12.96 | 109 | 121562 | 2701 | 50480752 |
Dizziness | 195.79 | 12.96 | 1463 | 120208 | 344906 | 50138547 |
Unevaluable event | 193.39 | 12.96 | 375 | 121296 | 45691 | 50437762 |
Disease progression | 185.30 | 12.96 | 579 | 121092 | 95287 | 50388166 |
Drug interaction | 184.62 | 12.96 | 127 | 121544 | 199494 | 50283959 |
Infusion site infection | 184.30 | 12.96 | 85 | 121586 | 1470 | 50481983 |
Febrile neutropenia | 181.55 | 12.96 | 14 | 121657 | 97653 | 50385800 |
Transplant evaluation | 171.13 | 12.96 | 72 | 121599 | 988 | 50482465 |
Musculoskeletal stiffness | 166.32 | 12.96 | 51 | 121620 | 128430 | 50355023 |
Condition aggravated | 166.17 | 12.96 | 1252 | 120419 | 295806 | 50187647 |
Stomatitis | 164.24 | 12.96 | 24 | 121647 | 101320 | 50382133 |
Cardiac operation | 163.39 | 12.96 | 95 | 121576 | 2700 | 50480753 |
Diarrhoea | 162.10 | 12.96 | 2139 | 119532 | 586337 | 49897116 |
Cardiac disorder | 157.88 | 12.96 | 331 | 121340 | 42648 | 50440805 |
Hypersensitivity | 156.41 | 12.96 | 172 | 121499 | 214989 | 50268464 |
Drug intolerance | 156.16 | 12.96 | 178 | 121493 | 218926 | 50264527 |
Malaise | 153.55 | 12.96 | 1351 | 120320 | 334181 | 50149272 |
Acute respiratory failure | 153.50 | 12.96 | 260 | 121411 | 28522 | 50454931 |
Catheter site rash | 151.72 | 12.96 | 60 | 121611 | 695 | 50482758 |
Therapy change | 150.03 | 12.96 | 114 | 121557 | 5111 | 50478342 |
Concomitant disease aggravated | 149.93 | 12.96 | 137 | 121534 | 7954 | 50475499 |
Hepatic enzyme increased | 148.90 | 12.96 | 72 | 121599 | 137308 | 50346145 |
Pericarditis | 147.03 | 12.96 | 11 | 121660 | 78678 | 50404775 |
Maternal exposure during pregnancy | 143.28 | 12.96 | 105 | 121566 | 159673 | 50323780 |
Psoriasis | 140.09 | 12.96 | 6 | 121665 | 68994 | 50414459 |
Device occlusion | 137.81 | 12.96 | 115 | 121556 | 5908 | 50477545 |
Dialysis | 137.50 | 12.96 | 140 | 121531 | 9298 | 50474155 |
Vascular device infection | 135.57 | 12.96 | 100 | 121571 | 4284 | 50479169 |
Catheter site irritation | 135.04 | 12.96 | 50 | 121621 | 477 | 50482976 |
Dermatitis contact | 132.83 | 12.96 | 132 | 121539 | 8514 | 50474939 |
Malignant neoplasm progression | 128.78 | 12.96 | 9 | 121662 | 68115 | 50415338 |
Pulmonary veno-occlusive disease | 127.25 | 12.96 | 57 | 121614 | 918 | 50482535 |
Epistaxis | 126.98 | 12.96 | 390 | 121281 | 63564 | 50419889 |
Urticaria | 125.72 | 12.96 | 78 | 121593 | 129483 | 50353970 |
Ascites | 123.43 | 12.96 | 269 | 121402 | 35592 | 50447861 |
Wound | 123.20 | 12.96 | 50 | 121621 | 105744 | 50377709 |
Drug abuse | 122.17 | 12.96 | 5 | 121666 | 59841 | 50423612 |
Pericardial effusion | 120.68 | 12.96 | 219 | 121452 | 25370 | 50458083 |
Exercise tolerance decreased | 119.76 | 12.96 | 97 | 121574 | 4777 | 50478676 |
Infusion site discharge | 119.71 | 12.96 | 48 | 121623 | 578 | 50482875 |
White blood cell count decreased | 117.86 | 12.96 | 67 | 121604 | 116655 | 50366798 |
Device infusion issue | 117.57 | 12.96 | 60 | 121611 | 1307 | 50482146 |
Dyspnoea at rest | 116.87 | 12.96 | 85 | 121586 | 3562 | 50479891 |
Infusion site swelling | 116.66 | 12.96 | 113 | 121558 | 7063 | 50476390 |
Hypertension | 116.32 | 12.96 | 206 | 121465 | 210997 | 50272456 |
Product dose omission issue | 115.38 | 12.96 | 797 | 120874 | 183041 | 50300412 |
Pruritus | 115.04 | 12.96 | 327 | 121344 | 283241 | 50200212 |
Injection site pain | 114.60 | 12.96 | 62 | 121609 | 110962 | 50372491 |
Chest discomfort | 114.42 | 12.96 | 484 | 121187 | 92238 | 50391215 |
Arthralgia | 112.10 | 12.96 | 609 | 121062 | 438093 | 50045360 |
Impaired healing | 111.96 | 12.96 | 17 | 121654 | 69769 | 50413684 |
Abdominal distension | 111.37 | 12.96 | 407 | 121264 | 72496 | 50410957 |
Complication associated with device | 105.49 | 12.96 | 152 | 121519 | 14503 | 50468950 |
Catheter site inflammation | 105.38 | 12.96 | 45 | 121626 | 642 | 50482811 |
Therapeutic product effect incomplete | 105.34 | 12.96 | 44 | 121627 | 91471 | 50391982 |
Paracentesis | 105.22 | 12.96 | 49 | 121622 | 867 | 50482586 |
Haemoptysis | 104.64 | 12.96 | 206 | 121465 | 25367 | 50458086 |
Pulmonary hypertensive crisis | 103.62 | 12.96 | 32 | 121639 | 163 | 50483290 |
Discomfort | 102.73 | 12.96 | 67 | 121604 | 108313 | 50375140 |
Device dislocation | 101.09 | 12.96 | 184 | 121487 | 21362 | 50462091 |
Systemic lupus erythematosus | 97.15 | 12.96 | 117 | 121554 | 140505 | 50342948 |
Anaphylactic reaction | 97.00 | 12.96 | 9 | 121662 | 54046 | 50429407 |
N-terminal prohormone brain natriuretic peptide increased | 96.99 | 12.96 | 57 | 121614 | 1653 | 50481800 |
Presyncope | 96.69 | 12.96 | 193 | 121478 | 24005 | 50459448 |
Brain natriuretic peptide increased | 96.52 | 12.96 | 83 | 121588 | 4444 | 50479009 |
Confusional state | 96.46 | 12.96 | 188 | 121483 | 185740 | 50297713 |
Blood cholesterol increased | 94.42 | 12.96 | 11 | 121660 | 55204 | 50428249 |
Right ventricular dysfunction | 93.52 | 12.96 | 54 | 121617 | 1514 | 50481939 |
Catheter site related reaction | 92.74 | 12.96 | 43 | 121628 | 753 | 50482700 |
Off label use | 92.45 | 12.96 | 715 | 120956 | 473711 | 50009742 |
Productive cough | 92.43 | 12.96 | 308 | 121363 | 52386 | 50431067 |
Walking distance test abnormal | 91.75 | 12.96 | 38 | 121633 | 500 | 50482953 |
Depression | 89.56 | 12.96 | 163 | 121508 | 165260 | 50318193 |
Psoriatic arthropathy | 89.51 | 12.96 | 6 | 121665 | 47026 | 50436427 |
Overdose | 88.76 | 12.96 | 66 | 121605 | 99661 | 50383792 |
Electrocardiogram QT prolonged | 87.09 | 12.96 | 11 | 121660 | 51875 | 50431578 |
Multiple sclerosis relapse | 86.33 | 12.96 | 4 | 121667 | 42960 | 50440493 |
Cardiac pacemaker insertion | 86.18 | 12.96 | 71 | 121600 | 3582 | 50479871 |
Emergency care | 84.74 | 12.96 | 41 | 121630 | 793 | 50482660 |
Helicobacter infection | 84.74 | 12.96 | 10 | 121661 | 49692 | 50433761 |
Neutrophil count decreased | 84.38 | 12.96 | 7 | 121664 | 46019 | 50437434 |
Mobility decreased | 83.44 | 12.96 | 44 | 121627 | 79904 | 50403549 |
Blister | 83.43 | 12.96 | 51 | 121620 | 85367 | 50398086 |
Suicidal ideation | 83.32 | 12.96 | 16 | 121655 | 55369 | 50428084 |
Mucosal inflammation | 83.14 | 12.96 | 3 | 121668 | 40139 | 50443314 |
Leukopenia | 81.77 | 12.96 | 30 | 121641 | 67498 | 50415955 |
Injection site erythema | 81.57 | 12.96 | 39 | 121632 | 74897 | 50408556 |
Blood pressure increased | 81.54 | 12.96 | 121 | 121550 | 133011 | 50350442 |
Myalgia | 81.52 | 12.96 | 545 | 121126 | 123774 | 50359679 |
Folliculitis | 81 | 12.96 | 3 | 121668 | 39222 | 50444231 |
Intentional overdose | 80.50 | 12.96 | 25 | 121646 | 62479 | 50420974 |
Osteoarthritis | 78.92 | 12.96 | 33 | 121638 | 68573 | 50414880 |
Influenza | 78.85 | 12.96 | 424 | 121247 | 89114 | 50394339 |
Oxygen therapy | 78.83 | 12.96 | 51 | 121620 | 1761 | 50481692 |
Heart rate increased | 78.63 | 12.96 | 381 | 121290 | 76869 | 50406584 |
Injection site reaction | 78.42 | 12.96 | 13 | 121658 | 50019 | 50433434 |
Cardiac ablation | 78.34 | 12.96 | 45 | 121626 | 1249 | 50482204 |
Infusion site haemorrhage | 76.39 | 12.96 | 61 | 121610 | 2943 | 50480510 |
Neuropathy peripheral | 76.30 | 12.96 | 72 | 121599 | 96685 | 50386768 |
Heart transplant | 75.95 | 12.96 | 31 | 121640 | 392 | 50483061 |
Cyanosis | 75.49 | 12.96 | 133 | 121538 | 15051 | 50468402 |
Atrial flutter | 75.28 | 12.96 | 99 | 121572 | 8664 | 50474789 |
Muscle injury | 72.84 | 12.96 | 4 | 121667 | 37107 | 50446346 |
Therapy non-responder | 72.20 | 12.96 | 278 | 121393 | 50744 | 50432709 |
Blood pressure decreased | 72.18 | 12.96 | 296 | 121375 | 55613 | 50427840 |
Injection site bruising | 72.05 | 12.96 | 4 | 121667 | 36764 | 50446689 |
Suicide attempt | 71.63 | 12.96 | 18 | 121653 | 51714 | 50431739 |
Catheter site vesicles | 71.27 | 12.96 | 27 | 121644 | 276 | 50483177 |
Cor pulmonale | 69.77 | 12.96 | 48 | 121623 | 1839 | 50481614 |
Infusion site pruritus | 69.71 | 12.96 | 65 | 121606 | 3872 | 50479581 |
Lower respiratory tract infection | 68.10 | 12.96 | 77 | 121594 | 95124 | 50388329 |
Irritable bowel syndrome | 67.29 | 12.96 | 20 | 121651 | 51421 | 50432032 |
Abdominal cavity drainage | 64.80 | 12.96 | 27 | 121644 | 361 | 50483092 |
Pancytopenia | 64.54 | 12.96 | 64 | 121607 | 83966 | 50399487 |
Coma | 64.40 | 12.96 | 28 | 121643 | 56851 | 50426602 |
Disease complication | 63.40 | 12.96 | 53 | 121618 | 2729 | 50480724 |
Systemic scleroderma | 63.31 | 12.96 | 34 | 121637 | 825 | 50482628 |
Mechanical ventilation | 63.27 | 12.96 | 38 | 121633 | 1148 | 50482305 |
Device related sepsis | 62.75 | 12.96 | 58 | 121613 | 3417 | 50480036 |
Right ventricular dilatation | 62.61 | 12.96 | 35 | 121636 | 921 | 50482532 |
Balloon atrial septostomy | 62.61 | 12.96 | 18 | 121653 | 68 | 50483385 |
Lung disorder | 61.68 | 12.96 | 242 | 121429 | 44557 | 50438896 |
Oxygen saturation abnormal | 60.59 | 12.96 | 51 | 121620 | 2651 | 50480802 |
Wrong technique in product usage process | 60.24 | 12.96 | 29 | 121642 | 55481 | 50427972 |
Infusion site induration | 60.02 | 12.96 | 33 | 121638 | 840 | 50482613 |
Product use in unapproved indication | 59.26 | 12.96 | 118 | 121553 | 115701 | 50367752 |
Acute kidney injury | 57.84 | 12.96 | 317 | 121354 | 227741 | 50255712 |
Neoplasm progression | 57.67 | 12.96 | 3 | 121668 | 29154 | 50454299 |
Right ventricular systolic pressure increased | 57.61 | 12.96 | 27 | 121644 | 485 | 50482968 |
Heart and lung transplant | 57.60 | 12.96 | 18 | 121653 | 96 | 50483357 |
Sleep disorder due to general medical condition, insomnia type | 57.05 | 12.96 | 5 | 121666 | 31442 | 50452011 |
Pain | 56.65 | 12.96 | 1016 | 120655 | 577887 | 49905566 |
Depressed level of consciousness | 56.59 | 12.96 | 27 | 121644 | 51926 | 50431527 |
Chronic respiratory failure | 56.15 | 12.96 | 40 | 121631 | 1622 | 50481831 |
Ventilation perfusion mismatch | 56.11 | 12.96 | 21 | 121650 | 207 | 50483246 |
Deep vein thrombosis | 56.10 | 12.96 | 56 | 121615 | 73248 | 50410205 |
Infusion site irritation | 55.40 | 12.96 | 28 | 121643 | 597 | 50482856 |
Tracheostomy | 55.31 | 12.96 | 27 | 121644 | 533 | 50482920 |
Paraesthesia | 55.31 | 12.96 | 130 | 121541 | 120113 | 50363340 |
Pain in extremity | 54.81 | 12.96 | 941 | 120730 | 271924 | 50211529 |
Cardioversion | 54.22 | 12.96 | 34 | 121637 | 1111 | 50482342 |
Terminal state | 53.98 | 12.96 | 43 | 121628 | 2067 | 50481386 |
Thrombocytopenia | 53.32 | 12.96 | 145 | 121526 | 127528 | 50355925 |
Catheter removal | 53.31 | 12.96 | 23 | 121648 | 337 | 50483116 |
Infusion site cellulitis | 52.78 | 12.96 | 19 | 121652 | 166 | 50483287 |
Atrial septal defect repair | 52.75 | 12.96 | 20 | 121651 | 205 | 50483248 |
Sedation | 52.57 | 12.96 | 6 | 121665 | 30604 | 50452849 |
Thrombosis in device | 51.93 | 12.96 | 47 | 121624 | 2694 | 50480759 |
Congestive hepatopathy | 51.70 | 12.96 | 45 | 121626 | 2449 | 50481004 |
Type 2 diabetes mellitus | 51.55 | 12.96 | 10 | 121661 | 34365 | 50449088 |
Gout | 51.34 | 12.96 | 96 | 121575 | 11374 | 50472079 |
Bone marrow failure | 51.19 | 12.96 | 4 | 121667 | 27620 | 50455833 |
Fibromyalgia | 51.14 | 12.96 | 22 | 121649 | 44956 | 50438497 |
Dependence on oxygen therapy | 51.13 | 12.96 | 22 | 121649 | 320 | 50483133 |
Internal haemorrhage | 51.10 | 12.96 | 58 | 121613 | 4359 | 50479094 |
Pulmonary arterial pressure abnormal | 51.01 | 12.96 | 24 | 121647 | 435 | 50483018 |
Chronic obstructive pulmonary disease | 50.43 | 12.96 | 258 | 121413 | 53177 | 50430276 |
Injection site discharge | 50.17 | 12.96 | 23 | 121648 | 392 | 50483061 |
Catheter site warmth | 49.83 | 12.96 | 19 | 121652 | 198 | 50483255 |
Hypoglycaemia | 49.57 | 12.96 | 34 | 121637 | 53547 | 50429906 |
Infusion site warmth | 49.57 | 12.96 | 35 | 121636 | 1399 | 50482054 |
Therapeutic response decreased | 49.26 | 12.96 | 26 | 121645 | 47205 | 50436248 |
Hypoaesthesia | 49.14 | 12.96 | 150 | 121521 | 127107 | 50356346 |
Device connection issue | 49.09 | 12.96 | 25 | 121646 | 542 | 50482911 |
Feeling abnormal | 48.98 | 12.96 | 489 | 121182 | 125003 | 50358450 |
Intentional product use issue | 48.96 | 12.96 | 68 | 121603 | 76850 | 50406603 |
Nausea | 48.69 | 12.96 | 2115 | 119556 | 703283 | 49780170 |
Right ventricular hypertrophy | 48.22 | 12.96 | 26 | 121645 | 636 | 50482817 |
Injury | 48.06 | 12.96 | 29 | 121642 | 48896 | 50434557 |
Pleural effusion | 48.00 | 12.96 | 348 | 121323 | 81106 | 50402347 |
Cognitive disorder | 47.95 | 12.96 | 23 | 121648 | 44100 | 50439353 |
Drug reaction with eosinophilia and systemic symptoms | 47.76 | 12.96 | 6 | 121665 | 28418 | 50455035 |
Blood culture positive | 47.19 | 12.96 | 55 | 121616 | 4253 | 50479200 |
Respiratory distress | 47.19 | 12.96 | 171 | 121500 | 30318 | 50453135 |
Angioedema | 46.87 | 12.96 | 16 | 121655 | 37660 | 50445793 |
Concomitant disease progression | 46.69 | 12.96 | 39 | 121632 | 2006 | 50481447 |
Device breakage | 46.65 | 12.96 | 83 | 121588 | 9464 | 50473989 |
Injection site swelling | 46.60 | 12.96 | 21 | 121650 | 41752 | 50441701 |
Arthritis | 46.40 | 12.96 | 86 | 121585 | 86635 | 50396818 |
Ill-defined disorder | 46.30 | 12.96 | 38 | 121633 | 54616 | 50428837 |
C-reactive protein increased | 46.20 | 12.96 | 55 | 121616 | 66419 | 50417034 |
Medical device change | 45.69 | 12.96 | 20 | 121651 | 304 | 50483149 |
Injection site pruritus | 45.57 | 12.96 | 20 | 121651 | 40391 | 50443062 |
Rhinovirus infection | 45.36 | 12.96 | 49 | 121622 | 3485 | 50479968 |
Hallucination | 45.35 | 12.96 | 28 | 121643 | 46629 | 50436824 |
Rehabilitation therapy | 45.28 | 12.96 | 32 | 121639 | 1281 | 50482172 |
Inappropriate schedule of product administration | 45.22 | 12.96 | 64 | 121607 | 71767 | 50411686 |
Finger amputation | 44.90 | 12.96 | 23 | 121648 | 505 | 50482948 |
Aspiration pleural cavity | 44.71 | 12.96 | 26 | 121645 | 739 | 50482714 |
Respiration abnormal | 44.38 | 12.96 | 58 | 121613 | 5044 | 50478409 |
Infusion site abscess | 44.18 | 12.96 | 17 | 121654 | 182 | 50483271 |
Hyponatraemia | 44.15 | 12.96 | 104 | 121567 | 96035 | 50387418 |
Peripheral swelling | 43.43 | 12.96 | 716 | 120955 | 205220 | 50278233 |
Red blood cell sedimentation rate increased | 43.19 | 12.96 | 9 | 121662 | 29407 | 50454046 |
Device physical property issue | 43.16 | 12.96 | 34 | 121637 | 1608 | 50481845 |
Transplant | 43.12 | 12.96 | 24 | 121647 | 626 | 50482827 |
Stent placement | 42.96 | 12.96 | 47 | 121624 | 3391 | 50480062 |
Delirium | 42.91 | 12.96 | 19 | 121652 | 38173 | 50445280 |
Abortion spontaneous | 42.10 | 12.96 | 24 | 121647 | 41748 | 50441705 |
Catheterisation cardiac abnormal | 42.08 | 12.96 | 17 | 121654 | 209 | 50483244 |
Device malfunction | 41.68 | 12.96 | 104 | 121567 | 15017 | 50468436 |
Emotional distress | 41.61 | 12.96 | 9 | 121662 | 28654 | 50454799 |
Liver transplant | 41.26 | 12.96 | 37 | 121634 | 2095 | 50481358 |
Blood creatine phosphokinase increased | 40.98 | 12.96 | 7 | 121664 | 26360 | 50457093 |
Lung assist device therapy | 40.89 | 12.96 | 13 | 121658 | 74 | 50483379 |
Blood potassium decreased | 40.33 | 12.96 | 186 | 121485 | 36759 | 50446694 |
Dizziness postural | 40.28 | 12.96 | 61 | 121610 | 6084 | 50477369 |
Biopsy liver | 39.43 | 12.96 | 19 | 121652 | 364 | 50483089 |
Cardiac failure acute | 39.39 | 12.96 | 71 | 121600 | 8179 | 50475274 |
Lymphocyte count decreased | 38.72 | 12.96 | 8 | 121663 | 26299 | 50457154 |
Drug-induced liver injury | 38.46 | 12.96 | 10 | 121661 | 28085 | 50455368 |
Exposure during pregnancy | 37.80 | 12.96 | 156 | 121515 | 120859 | 50362594 |
Right ventricular enlargement | 37.61 | 12.96 | 17 | 121654 | 280 | 50483173 |
Inflammation | 37.55 | 12.96 | 49 | 121622 | 56863 | 50426590 |
Catheter site discolouration | 37.11 | 12.96 | 13 | 121658 | 104 | 50483349 |
Product quality issue | 36.86 | 12.96 | 14 | 121657 | 30844 | 50452609 |
Generalised tonic-clonic seizure | 36.72 | 12.96 | 9 | 121662 | 26301 | 50457152 |
Catheter site nodule | 36.46 | 12.96 | 11 | 121660 | 51 | 50483402 |
Seizure | 36.16 | 12.96 | 153 | 121518 | 117721 | 50365732 |
Plasma cell myeloma | 36.12 | 12.96 | 15 | 121656 | 31307 | 50452146 |
Oral herpes | 35.75 | 12.96 | 4 | 121667 | 20721 | 50462732 |
Catheter site extravasation | 35.59 | 12.96 | 16 | 121655 | 260 | 50483193 |
Left-to-right cardiac shunt | 35.30 | 12.96 | 13 | 121658 | 122 | 50483331 |
Hyperglycaemia | 35.17 | 12.96 | 22 | 121649 | 36383 | 50447070 |
Pulmonary congestion | 35.04 | 12.96 | 98 | 121573 | 15149 | 50468304 |
Renal disorder | 35.00 | 12.96 | 145 | 121526 | 27360 | 50456093 |
Foot deformity | 34.99 | 12.96 | 3 | 121668 | 19207 | 50464246 |
Blood pressure systolic increased | 34.83 | 12.96 | 21 | 121650 | 35428 | 50448025 |
Basal cell carcinoma | 34.59 | 12.96 | 7 | 121664 | 23349 | 50460104 |
Disease recurrence | 34.33 | 12.96 | 4 | 121667 | 20077 | 50463376 |
Catheter site scab | 34.30 | 12.96 | 14 | 121657 | 177 | 50483276 |
Sinus congestion | 34.30 | 12.96 | 92 | 121579 | 13879 | 50469574 |
Drug withdrawal syndrome | 34.19 | 12.96 | 9 | 121662 | 25072 | 50458381 |
Right-to-left cardiac shunt | 34.09 | 12.96 | 14 | 121657 | 180 | 50483273 |
Hepatocellular injury | 34.09 | 12.96 | 10 | 121661 | 25937 | 50457516 |
Bone disorder | 33.96 | 12.96 | 3 | 121668 | 18749 | 50464704 |
Sopor | 33.88 | 12.96 | 4 | 121667 | 19875 | 50463578 |
Lactic acidosis | 33.85 | 12.96 | 19 | 121652 | 33336 | 50450117 |
Pulmonary vascular resistance abnormality | 33.76 | 12.96 | 10 | 121661 | 43 | 50483410 |
Decreased appetite | 33.70 | 12.96 | 674 | 120997 | 200249 | 50283204 |
Drug dependence | 33.62 | 12.96 | 4 | 121667 | 19755 | 50463698 |
Balance disorder | 33.51 | 12.96 | 75 | 121596 | 70515 | 50412938 |
Drug eruption | 33.09 | 12.96 | 8 | 121663 | 23598 | 50459855 |
Acute right ventricular failure | 32.69 | 12.96 | 13 | 121658 | 153 | 50483300 |
Sinusitis | 32.62 | 12.96 | 258 | 121413 | 170300 | 50313153 |
Asthma | 32.59 | 12.96 | 108 | 121563 | 89229 | 50394224 |
Paranasal sinus hypersecretion | 32.57 | 12.96 | 39 | 121632 | 3103 | 50480350 |
Swollen tongue | 32.55 | 12.96 | 14 | 121657 | 28616 | 50454837 |
Orthopnoea | 32.47 | 12.96 | 53 | 121618 | 5636 | 50477817 |
Osteoporosis | 32.41 | 12.96 | 36 | 121635 | 44843 | 50438610 |
Bursitis | 32.03 | 12.96 | 7 | 121664 | 22128 | 50461325 |
Diabetic ketoacidosis | 31.99 | 12.96 | 3 | 121668 | 17869 | 50465584 |
Aggression | 31.97 | 12.96 | 6 | 121665 | 21110 | 50462343 |
Drug resistance | 31.92 | 12.96 | 4 | 121667 | 18985 | 50464468 |
Hospice care | 31.90 | 12.96 | 53 | 121618 | 5719 | 50477734 |
Product supply issue | 31.89 | 12.96 | 25 | 121646 | 1174 | 50482279 |
Dysentery | 31.83 | 12.96 | 21 | 121650 | 750 | 50482703 |
Central venous catheter removal | 31.54 | 12.96 | 16 | 121655 | 344 | 50483109 |
Localised oedema | 31.46 | 12.96 | 48 | 121623 | 4819 | 50478634 |
Pulmonary pain | 31.30 | 12.96 | 33 | 121638 | 2282 | 50481171 |
Stevens-Johnson syndrome | 31.23 | 12.96 | 7 | 121664 | 21745 | 50461708 |
Blood culture negative | 31.22 | 12.96 | 12 | 121659 | 128 | 50483325 |
Incorrect route of product administration | 31.22 | 12.96 | 4 | 121667 | 18662 | 50464791 |
Atrial fibrillation | 31.19 | 12.96 | 378 | 121293 | 101367 | 50382086 |
Adverse drug reaction | 31.13 | 12.96 | 53 | 121618 | 55169 | 50428284 |
Retching | 30.88 | 12.96 | 84 | 121587 | 12778 | 50470675 |
Treatment noncompliance | 30.87 | 12.96 | 149 | 121522 | 30001 | 50453452 |
Infusion site discolouration | 30.79 | 12.96 | 19 | 121652 | 603 | 50482850 |
Medication error | 30.70 | 12.96 | 25 | 121646 | 36079 | 50447374 |
Multiple sclerosis | 30.65 | 12.96 | 6 | 121665 | 20487 | 50462966 |
Pulmonary artery aneurysm | 30.51 | 12.96 | 9 | 121662 | 38 | 50483415 |
Blood bilirubin increased | 30.44 | 12.96 | 155 | 121516 | 31883 | 50451570 |
Pulmonary artery dilatation | 30.15 | 12.96 | 14 | 121657 | 246 | 50483207 |
Infusion site oedema | 30.11 | 12.96 | 18 | 121653 | 539 | 50482914 |
Intentional product misuse | 30.05 | 12.96 | 41 | 121630 | 46693 | 50436760 |
Endotracheal intubation | 29.65 | 12.96 | 31 | 121640 | 2123 | 50481330 |
Orthostatic hypotension | 29.62 | 12.96 | 17 | 121654 | 29464 | 50453989 |
Vascular resistance pulmonary decreased | 29.34 | 12.96 | 10 | 121661 | 73 | 50483380 |
Systemic-pulmonary artery shunt | 29.23 | 12.96 | 8 | 121663 | 24 | 50483429 |
Hepatic steatosis | 29.23 | 12.96 | 11 | 121660 | 24373 | 50459080 |
Therapeutic embolisation | 29.17 | 12.96 | 12 | 121659 | 155 | 50483298 |
Skin lesion | 28.94 | 12.96 | 14 | 121657 | 26713 | 50456740 |
Carbon dioxide increased | 28.87 | 12.96 | 23 | 121648 | 1106 | 50482347 |
Seasonal allergy | 28.64 | 12.96 | 89 | 121582 | 14587 | 50468866 |
Gastrostomy | 28.44 | 12.96 | 17 | 121654 | 509 | 50482944 |
Pulmonary arterial wedge pressure increased | 28.24 | 12.96 | 14 | 121657 | 286 | 50483167 |
Metabolic acidosis | 28.19 | 12.96 | 31 | 121640 | 38794 | 50444659 |
Dyskinesia | 28.09 | 12.96 | 16 | 121655 | 27845 | 50455608 |
Aphasia | 27.83 | 12.96 | 17 | 121654 | 28477 | 50454976 |
Agitation | 27.62 | 12.96 | 54 | 121617 | 53330 | 50430123 |
Heart valve operation | 27.62 | 12.96 | 11 | 121660 | 130 | 50483323 |
Hypocalcaemia | 27.61 | 12.96 | 15 | 121656 | 26801 | 50456652 |
Device issue | 27.57 | 12.96 | 108 | 121563 | 19864 | 50463589 |
Metastases to bone | 27.48 | 12.96 | 5 | 121666 | 17990 | 50465463 |
Application site irritation | 27.32 | 12.96 | 26 | 121645 | 1589 | 50481864 |
Foetal exposure during pregnancy | 27.17 | 12.96 | 16 | 121655 | 27343 | 50456110 |
Application site pruritus | 27.07 | 12.96 | 39 | 121632 | 3720 | 50479733 |
Viral infection | 27.05 | 12.96 | 143 | 121528 | 29843 | 50453610 |
Dysarthria | 27.01 | 12.96 | 30 | 121641 | 37373 | 50446080 |
Device programming error | 26.98 | 12.96 | 9 | 121662 | 61 | 50483392 |
Lymphopenia | 26.98 | 12.96 | 3 | 121668 | 15618 | 50467835 |
Sleep study | 26.94 | 12.96 | 7 | 121664 | 16 | 50483437 |
Gastrointestinal haemorrhage | 26.82 | 12.96 | 282 | 121389 | 73039 | 50410414 |
Accidental exposure to product | 26.65 | 12.96 | 11 | 121660 | 23046 | 50460407 |
Patent ductus arteriosus repair | 26.65 | 12.96 | 7 | 121664 | 17 | 50483436 |
Pulmonary arterial pressure | 26.65 | 12.96 | 7 | 121664 | 17 | 50483436 |
Cardiac output decreased | 26.64 | 12.96 | 20 | 121651 | 880 | 50482573 |
Constipation | 26.50 | 12.96 | 302 | 121369 | 185406 | 50298047 |
Hyperlipidaemia | 26.41 | 12.96 | 5 | 121666 | 17485 | 50465968 |
Dialysis related complication | 26.14 | 12.96 | 9 | 121662 | 68 | 50483385 |
Dysphagia | 26.06 | 12.96 | 97 | 121574 | 77421 | 50406032 |
Disturbance in attention | 26.02 | 12.96 | 22 | 121649 | 31164 | 50452289 |
Sudden death | 26.01 | 12.96 | 63 | 121608 | 8928 | 50474525 |
Hernia repair | 25.82 | 12.96 | 23 | 121648 | 1291 | 50482162 |
Acute myeloid leukaemia | 25.77 | 12.96 | 3 | 121668 | 15071 | 50468382 |
Jugular vein distension | 25.69 | 12.96 | 19 | 121652 | 817 | 50482636 |
Pneumonitis | 25.64 | 12.96 | 20 | 121651 | 29490 | 50453963 |
Mouth ulceration | 25.63 | 12.96 | 18 | 121653 | 28006 | 50455447 |
Generalised oedema | 25.63 | 12.96 | 82 | 121589 | 13649 | 50469804 |
Osteonecrosis | 25.62 | 12.96 | 11 | 121660 | 22506 | 50460947 |
Therapy cessation | 25.52 | 12.96 | 127 | 121544 | 25884 | 50457569 |
Posterior reversible encephalopathy syndrome | 25.45 | 12.96 | 3 | 121668 | 14925 | 50468528 |
Infusion site rash | 25.40 | 12.96 | 23 | 121648 | 1319 | 50482134 |
Nasopharyngitis | 25.32 | 12.96 | 625 | 121046 | 192302 | 50291151 |
Prescribed underdose | 25.31 | 12.96 | 4 | 121667 | 15945 | 50467508 |
Full blood count decreased | 25.29 | 12.96 | 11 | 121660 | 22335 | 50461118 |
Coronary artery compression | 25.17 | 12.96 | 5 | 121666 | 0 | 50483453 |
Anti factor VIII antibody test | 25.17 | 12.96 | 5 | 121666 | 0 | 50483453 |
Carpal tunnel syndrome | 25.15 | 12.96 | 5 | 121666 | 16888 | 50466565 |
Abnormal behaviour | 25.06 | 12.96 | 8 | 121663 | 19650 | 50463803 |
Urinary retention | 25.06 | 12.96 | 16 | 121655 | 26174 | 50457279 |
CREST syndrome | 24.86 | 12.96 | 15 | 121656 | 457 | 50482996 |
Blood glucose increased | 24.80 | 12.96 | 88 | 121583 | 71236 | 50412217 |
Injection site mass | 24.73 | 12.96 | 4 | 121667 | 15676 | 50467777 |
Liver function test abnormal | 24.72 | 12.96 | 187 | 121484 | 44152 | 50439301 |
Platelet count increased | 24.60 | 12.96 | 3 | 121668 | 14537 | 50468916 |
Withdrawal syndrome | 24.58 | 12.96 | 6 | 121665 | 17584 | 50465869 |
Head discomfort | 24.51 | 12.96 | 70 | 121601 | 10949 | 50472504 |
Blood pressure fluctuation | 24.50 | 12.96 | 30 | 121641 | 35793 | 50447660 |
Eczema | 24.41 | 12.96 | 12 | 121659 | 22690 | 50460763 |
Ventricular septal defect repair | 24.34 | 12.96 | 6 | 121665 | 10 | 50483443 |
Pulmonary embolism | 24.32 | 12.96 | 144 | 121527 | 101560 | 50381893 |
Nasal dryness | 24.13 | 12.96 | 36 | 121635 | 3543 | 50479910 |
Staphylococcus test positive | 24.03 | 12.96 | 35 | 121636 | 3371 | 50480082 |
Immunoglobulin G4 related disease | 24.01 | 12.96 | 8 | 121663 | 54 | 50483399 |
Rales | 23.79 | 12.96 | 65 | 121606 | 9913 | 50473540 |
Blood alkaline phosphatase increased | 23.65 | 12.96 | 163 | 121508 | 37363 | 50446090 |
Rhinorrhoea | 23.60 | 12.96 | 208 | 121463 | 51375 | 50432078 |
Somnolence | 23.31 | 12.96 | 249 | 121422 | 154736 | 50328717 |
Sinus disorder | 23.24 | 12.96 | 97 | 121574 | 18361 | 50465092 |
Infection | 23.23 | 12.96 | 285 | 121386 | 172669 | 50310784 |
Respiratory syncytial virus infection | 23.21 | 12.96 | 43 | 121628 | 5059 | 50478394 |
Mood swings | 23.18 | 12.96 | 5 | 121666 | 15949 | 50467504 |
Skin exfoliation | 23.15 | 12.96 | 28 | 121643 | 33584 | 50449869 |
Diagnostic procedure | 23.09 | 12.96 | 9 | 121662 | 100 | 50483353 |
Dizziness exertional | 23.09 | 12.96 | 13 | 121658 | 347 | 50483106 |
Night sweats | 23.09 | 12.96 | 28 | 121643 | 33546 | 50449907 |
Pericardial drainage | 22.91 | 12.96 | 11 | 121660 | 209 | 50483244 |
Hyperkalaemia | 22.90 | 12.96 | 51 | 121620 | 48038 | 50435415 |
Cardiac failure chronic | 22.83 | 12.96 | 35 | 121636 | 3528 | 50479925 |
Joint range of motion decreased | 22.78 | 12.96 | 8 | 121663 | 18504 | 50464949 |
Application site odour | 22.77 | 12.96 | 7 | 121664 | 35 | 50483418 |
Cardiac flutter | 22.71 | 12.96 | 34 | 121637 | 3356 | 50480097 |
Haemorrhage | 22.68 | 12.96 | 212 | 121459 | 53229 | 50430224 |
Pulmonary haemorrhage | 22.67 | 12.96 | 49 | 121622 | 6443 | 50477010 |
Metastases to liver | 22.59 | 12.96 | 10 | 121661 | 20094 | 50463359 |
Drug level increased | 22.59 | 12.96 | 9 | 121662 | 19259 | 50464194 |
Hypokalaemia | 22.43 | 12.96 | 122 | 121549 | 87870 | 50395583 |
Nocturnal dyspnoea | 22.42 | 12.96 | 19 | 121652 | 997 | 50482456 |
Myelosuppression | 22.36 | 12.96 | 3 | 121668 | 13514 | 50469939 |
Epilepsy | 22.30 | 12.96 | 12 | 121659 | 21555 | 50461898 |
Left ventricular failure | 22.27 | 12.96 | 41 | 121630 | 4800 | 50478653 |
Tracheostomy tube removal | 22.24 | 12.96 | 5 | 121666 | 4 | 50483449 |
Joint stiffness | 22.23 | 12.96 | 24 | 121647 | 30284 | 50453169 |
Musculoskeletal disorder | 22.22 | 12.96 | 7 | 121664 | 17342 | 50466111 |
Pancreatitis acute | 22.17 | 12.96 | 15 | 121656 | 23797 | 50459656 |
Body temperature decreased | 22.13 | 12.96 | 6 | 121665 | 16389 | 50467064 |
Exercise test abnormal | 22.11 | 12.96 | 9 | 121662 | 113 | 50483340 |
Hypothyroidism | 21.88 | 12.96 | 30 | 121641 | 34095 | 50449358 |
Abdominal discomfort | 21.76 | 12.96 | 409 | 121262 | 231232 | 50252221 |
Body temperature increased | 21.70 | 12.96 | 26 | 121645 | 31315 | 50452138 |
Sinus bradycardia | 21.63 | 12.96 | 3 | 121668 | 13180 | 50470273 |
Altered state of consciousness | 21.50 | 12.96 | 13 | 121658 | 21897 | 50461556 |
Catheter culture positive | 21.49 | 12.96 | 9 | 121662 | 122 | 50483331 |
Myelodysplastic syndrome | 21.46 | 12.96 | 5 | 121666 | 15127 | 50468326 |
Pulmonary arterial pressure decreased | 21.45 | 12.96 | 8 | 121663 | 78 | 50483375 |
Pulmonary vein stenosis | 21.45 | 12.96 | 8 | 121663 | 78 | 50483375 |
Tracheostomy malfunction | 21.44 | 12.96 | 7 | 121664 | 44 | 50483409 |
Hypercalcaemia | 21.35 | 12.96 | 15 | 121656 | 23337 | 50460116 |
Gastritis hypertrophic | 21.30 | 12.96 | 7 | 121664 | 45 | 50483408 |
Right atrial dilatation | 21.23 | 12.96 | 15 | 121656 | 600 | 50482853 |
Tenderness | 21.23 | 12.96 | 9 | 121662 | 18556 | 50464897 |
Cholestasis | 21.09 | 12.96 | 18 | 121653 | 25383 | 50458070 |
Infusion site inflammation | 21.05 | 12.96 | 11 | 121660 | 252 | 50483201 |
Cardiomegaly | 21.03 | 12.96 | 85 | 121586 | 15860 | 50467593 |
Herpes zoster | 21.01 | 12.96 | 93 | 121578 | 70693 | 50412760 |
Blood pressure abnormal | 21.01 | 12.96 | 73 | 121598 | 12674 | 50470779 |
Hypomagnesaemia | 21.01 | 12.96 | 15 | 121656 | 23141 | 50460312 |
Tendonitis | 20.94 | 12.96 | 7 | 121664 | 16698 | 50466755 |
Loss of personal independence in daily activities | 20.82 | 12.96 | 92 | 121579 | 69958 | 50413495 |
Chronic right ventricular failure | 20.80 | 12.96 | 6 | 121665 | 23 | 50483430 |
Cor pulmonale chronic | 20.78 | 12.96 | 10 | 121661 | 191 | 50483262 |
Large intestinal polypectomy | 20.78 | 12.96 | 10 | 121661 | 191 | 50483262 |
Cardiac arrest | 20.72 | 12.96 | 299 | 121372 | 83352 | 50400101 |
Ataxia | 20.69 | 12.96 | 4 | 121667 | 13782 | 50469671 |
Diet noncompliance | 20.63 | 12.96 | 11 | 121660 | 263 | 50483190 |
Aspartate aminotransferase increased | 20.61 | 12.96 | 282 | 121389 | 77716 | 50405737 |
Right atrial pressure increased | 20.61 | 12.96 | 9 | 121662 | 136 | 50483317 |
Ear tube insertion | 20.60 | 12.96 | 8 | 121663 | 88 | 50483365 |
Echocardiogram abnormal | 20.46 | 12.96 | 19 | 121652 | 1126 | 50482327 |
Cardiogenic shock | 20.45 | 12.96 | 83 | 121588 | 15516 | 50467937 |
Hyperhidrosis | 20.14 | 12.96 | 129 | 121542 | 89297 | 50394156 |
Increased ventricular preload | 20.13 | 12.96 | 4 | 121667 | 0 | 50483453 |
Cytomegalovirus infection | 20.08 | 12.96 | 9 | 121662 | 17953 | 50465500 |
Oxygen consumption | 20.05 | 12.96 | 8 | 121663 | 95 | 50483358 |
Intervertebral disc degeneration | 20.01 | 12.96 | 4 | 121667 | 13457 | 50469996 |
Injection site rash | 19.89 | 12.96 | 7 | 121664 | 16170 | 50467283 |
Status epilepticus | 19.89 | 12.96 | 4 | 121667 | 13402 | 50470051 |
Atrial tachycardia | 19.74 | 12.96 | 25 | 121646 | 2107 | 50481346 |
Tubulointerstitial nephritis | 19.73 | 12.96 | 6 | 121665 | 15205 | 50468248 |
Cardiorenal syndrome | 19.71 | 12.96 | 14 | 121657 | 565 | 50482888 |
Skin operation | 19.70 | 12.96 | 5 | 121666 | 10 | 50483443 |
Ammonia increased | 19.61 | 12.96 | 36 | 121635 | 4205 | 50479248 |
Catheter site dryness | 19.52 | 12.96 | 6 | 121665 | 30 | 50483423 |
Bradycardia | 19.52 | 12.96 | 84 | 121587 | 64342 | 50419111 |
Cyst | 19.47 | 12.96 | 3 | 121668 | 12184 | 50471269 |
Muscular weakness | 19.44 | 12.96 | 141 | 121530 | 94872 | 50388581 |
Deafness | 19.40 | 12.96 | 82 | 121589 | 15609 | 50467844 |
Catheter site cellulitis | 19.38 | 12.96 | 10 | 121661 | 223 | 50483230 |
Cardiac index decreased | 19.36 | 12.96 | 7 | 121664 | 62 | 50483391 |
Spinal osteoarthritis | 19.32 | 12.96 | 5 | 121666 | 14087 | 50469366 |
Catheter site hypersensitivity | 19.26 | 12.96 | 8 | 121663 | 106 | 50483347 |
Speech disorder | 19.23 | 12.96 | 35 | 121636 | 35513 | 50447940 |
Proteinuria | 19.05 | 12.96 | 8 | 121663 | 16589 | 50466864 |
Dry eye | 18.83 | 12.96 | 30 | 121641 | 32065 | 50451388 |
Acne | 18.71 | 12.96 | 12 | 121659 | 19583 | 50463870 |
Blood iron decreased | 18.70 | 12.96 | 66 | 121605 | 11549 | 50471904 |
Peritonitis | 18.54 | 12.96 | 7 | 121664 | 15479 | 50467974 |
Gastrointestinal tube insertion | 18.53 | 12.96 | 17 | 121654 | 992 | 50482461 |
Rheumatoid nodule | 18.48 | 12.96 | 4 | 121667 | 12731 | 50470722 |
Oesophagogastric fundoplasty | 18.44 | 12.96 | 7 | 121664 | 72 | 50483381 |
Vasodilatation | 18.43 | 12.96 | 25 | 121646 | 2254 | 50481199 |
Impaired work ability | 18.39 | 12.96 | 5 | 121666 | 13635 | 50469818 |
Eosinophilia | 18.39 | 12.96 | 11 | 121660 | 18641 | 50464812 |
Osteomyelitis | 18.36 | 12.96 | 16 | 121655 | 22337 | 50461116 |
Cerebral infarction | 18.32 | 12.96 | 15 | 121656 | 21589 | 50461864 |
Brain natriuretic peptide abnormal | 18.26 | 12.96 | 11 | 121660 | 334 | 50483119 |
Colitis | 18.23 | 12.96 | 41 | 121630 | 38488 | 50444965 |
Gastric antral vascular ectasia | 18.16 | 12.96 | 13 | 121658 | 531 | 50482922 |
Sepsis | 18.14 | 12.96 | 433 | 121238 | 132492 | 50350961 |
Cataract | 18.07 | 12.96 | 56 | 121615 | 47244 | 50436209 |
Colitis ulcerative | 17.99 | 12.96 | 9 | 121662 | 16845 | 50466608 |
Protein-losing gastroenteropathy | 17.98 | 12.96 | 9 | 121662 | 188 | 50483265 |
Infusion site ulcer | 17.90 | 12.96 | 4 | 121667 | 3 | 50483450 |
Cavopulmonary anastomosis | 17.90 | 12.96 | 4 | 121667 | 3 | 50483450 |
Cardiac failure high output | 17.89 | 12.96 | 10 | 121661 | 263 | 50483190 |
Ischaemic stroke | 17.81 | 12.96 | 8 | 121663 | 15940 | 50467513 |
Sudden visual loss | 17.80 | 12.96 | 5 | 121666 | 17 | 50483436 |
Infusion site injury | 17.80 | 12.96 | 5 | 121666 | 17 | 50483436 |
Contusion | 17.78 | 12.96 | 178 | 121493 | 112005 | 50371448 |
Femur fracture | 17.62 | 12.96 | 40 | 121631 | 37424 | 50446029 |
Metastases to central nervous system | 17.52 | 12.96 | 3 | 121668 | 11279 | 50472174 |
Toxic skin eruption | 17.46 | 12.96 | 3 | 121668 | 11248 | 50472205 |
Head injury | 17.37 | 12.96 | 108 | 121563 | 23912 | 50459541 |
Choking sensation | 17.31 | 12.96 | 29 | 121642 | 3151 | 50480302 |
Chronic hepatic failure | 17.23 | 12.96 | 12 | 121659 | 469 | 50482984 |
Sleep disorder | 17.16 | 12.96 | 75 | 121596 | 57208 | 50426245 |
Arteriovenous malformation | 17.13 | 12.96 | 18 | 121653 | 1240 | 50482213 |
Choking | 17.01 | 12.96 | 52 | 121619 | 8446 | 50475007 |
Hepatitis | 16.99 | 12.96 | 31 | 121640 | 31422 | 50452031 |
Hypothermia | 16.98 | 12.96 | 4 | 121667 | 12012 | 50471441 |
Metastases to lung | 16.96 | 12.96 | 3 | 121668 | 11017 | 50472436 |
Breast cancer | 16.94 | 12.96 | 50 | 121621 | 42840 | 50440613 |
Bacteraemia | 16.75 | 12.96 | 74 | 121597 | 14359 | 50469094 |
Pulseless electrical activity | 16.74 | 12.96 | 45 | 121626 | 6796 | 50476657 |
Radiotherapy | 16.71 | 12.96 | 10 | 121661 | 300 | 50483153 |
Encephalopathy | 16.67 | 12.96 | 35 | 121636 | 33676 | 50449777 |
Rash erythematous | 16.56 | 12.96 | 37 | 121634 | 34815 | 50448638 |
Throat irritation | 16.56 | 12.96 | 127 | 121544 | 30112 | 50453341 |
Optic ischaemic neuropathy | 16.50 | 12.96 | 16 | 121655 | 1001 | 50482452 |
Pulmonary valve replacement | 16.48 | 12.96 | 4 | 121667 | 6 | 50483447 |
Spinal stenosis | 16.43 | 12.96 | 6 | 121665 | 13544 | 50469909 |
Catheter site induration | 16.42 | 12.96 | 6 | 121665 | 55 | 50483398 |
Life support | 16.41 | 12.96 | 9 | 121662 | 228 | 50483225 |
Weight decreased | 16.39 | 12.96 | 669 | 121002 | 220576 | 50262877 |
Product administration interrupted | 16.34 | 12.96 | 16 | 121655 | 1013 | 50482440 |
Hypercholesterolaemia | 16.34 | 12.96 | 4 | 121667 | 11699 | 50471754 |
Coronary artery disease | 16.32 | 12.96 | 29 | 121642 | 29697 | 50453756 |
Suture insertion | 16.32 | 12.96 | 7 | 121664 | 101 | 50483352 |
Knee arthroplasty | 16.27 | 12.96 | 39 | 121632 | 35807 | 50447646 |
Biopsy | 16.16 | 12.96 | 11 | 121660 | 414 | 50483039 |
Upper respiratory tract infection | 16.10 | 12.96 | 235 | 121436 | 65663 | 50417790 |
Infusion site reaction | 16.05 | 12.96 | 23 | 121648 | 2183 | 50481270 |
Hallucination, visual | 16.04 | 12.96 | 10 | 121661 | 16572 | 50466881 |
Delusion | 16.00 | 12.96 | 3 | 121668 | 10566 | 50472887 |
Coordination abnormal | 15.99 | 12.96 | 4 | 121667 | 11530 | 50471923 |
Paranasal sinus discomfort | 15.95 | 12.96 | 27 | 121644 | 2959 | 50480494 |
Intra-abdominal haemorrhage | 15.94 | 12.96 | 23 | 121648 | 2197 | 50481256 |
Respiratory tract haemorrhage | 15.93 | 12.96 | 11 | 121660 | 424 | 50483029 |
Chemotherapy | 15.88 | 12.96 | 18 | 121653 | 1351 | 50482102 |
Portopulmonary hypertension | 15.84 | 12.96 | 7 | 121664 | 109 | 50483344 |
Biopsy lymph gland | 15.80 | 12.96 | 5 | 121666 | 28 | 50483425 |
Diabetes mellitus inadequate control | 15.64 | 12.96 | 6 | 121665 | 13139 | 50470314 |
Inferior vena cava dilatation | 15.61 | 12.96 | 6 | 121665 | 64 | 50483389 |
Diplopia | 15.56 | 12.96 | 14 | 121657 | 19246 | 50464207 |
Biopsy lung | 15.56 | 12.96 | 8 | 121663 | 177 | 50483276 |
Tremor | 15.55 | 12.96 | 189 | 121482 | 114714 | 50368739 |
Nephrolithiasis | 15.55 | 12.96 | 38 | 121633 | 34655 | 50448798 |
Injection site haemorrhage | 15.54 | 12.96 | 17 | 121654 | 21329 | 50462124 |
Blood triglycerides increased | 15.53 | 12.96 | 4 | 121667 | 11308 | 50472145 |
Ejection fraction decreased | 15.53 | 12.96 | 13 | 121658 | 18507 | 50464946 |
Nodule | 15.44 | 12.96 | 11 | 121660 | 16992 | 50466461 |
Injection site warmth | 15.42 | 12.96 | 7 | 121664 | 13859 | 50469594 |
Angioplasty | 15.41 | 12.96 | 17 | 121654 | 1238 | 50482215 |
Biopsy kidney | 15.39 | 12.96 | 7 | 121664 | 117 | 50483336 |
Metapneumovirus infection | 15.39 | 12.96 | 14 | 121657 | 808 | 50482645 |
Intentional medical device removal by patient | 15.34 | 12.96 | 7 | 121664 | 118 | 50483335 |
Implantable defibrillator insertion | 15.31 | 12.96 | 10 | 121661 | 351 | 50483102 |
Gait disturbance | 15.29 | 12.96 | 261 | 121410 | 149744 | 50333709 |
Mineral supplementation | 15.28 | 12.96 | 13 | 121658 | 686 | 50482767 |
Fistula repair | 15.23 | 12.96 | 5 | 121666 | 32 | 50483421 |
Ear discomfort | 15.16 | 12.96 | 43 | 121628 | 6701 | 50476752 |
Nightmare | 15.15 | 12.96 | 10 | 121661 | 16076 | 50467377 |
Breast tumour excision | 15.10 | 12.96 | 3 | 121668 | 0 | 50483453 |
Jejunostomy | 15.10 | 12.96 | 3 | 121668 | 0 | 50483453 |
Oral pain | 15.07 | 12.96 | 23 | 121648 | 25010 | 50458443 |
Bone density decreased | 15.05 | 12.96 | 4 | 121667 | 11071 | 50472382 |
Obesity | 15.04 | 12.96 | 11 | 121660 | 16764 | 50466689 |
Low cardiac output syndrome | 15.04 | 12.96 | 9 | 121662 | 270 | 50483183 |
Pulmonary thrombosis | 14.96 | 12.96 | 46 | 121625 | 7495 | 50475958 |
Pneumonia bacterial | 14.89 | 12.96 | 45 | 121626 | 7264 | 50476189 |
Heart valve replacement | 14.85 | 12.96 | 11 | 121660 | 474 | 50482979 |
Hereditary haemorrhagic telangiectasia | 14.85 | 12.96 | 5 | 121666 | 35 | 50483418 |
Wrong dose | 14.75 | 12.96 | 14 | 121657 | 853 | 50482600 |
Liver injury | 14.73 | 12.96 | 23 | 121648 | 24783 | 50458670 |
Clostridium difficile infection | 14.58 | 12.96 | 108 | 121563 | 25331 | 50458122 |
Neutrophil count increased | 14.53 | 12.96 | 8 | 121663 | 14187 | 50469266 |
Blood calcium decreased | 14.52 | 12.96 | 17 | 121654 | 20689 | 50462764 |
Unevaluable investigation | 14.50 | 12.96 | 5 | 121666 | 38 | 50483415 |
Infusion site vesicles | 14.42 | 12.96 | 10 | 121661 | 388 | 50483065 |
Intracardiac pressure increased | 14.39 | 12.96 | 5 | 121666 | 39 | 50483414 |
Haemodynamic test abnormal | 14.39 | 12.96 | 5 | 121666 | 39 | 50483414 |
Cardiac output increased | 14.35 | 12.96 | 7 | 121664 | 138 | 50483315 |
Hallucination, auditory | 14.34 | 12.96 | 4 | 121667 | 10724 | 50472729 |
Skin irritation | 14.29 | 12.96 | 46 | 121625 | 7681 | 50475772 |
Sickle cell anaemia | 14.28 | 12.96 | 11 | 121660 | 503 | 50482950 |
Disorientation | 14.28 | 12.96 | 41 | 121630 | 35443 | 50448010 |
Product substitution issue | 14.27 | 12.96 | 8 | 121663 | 14049 | 50469404 |
Poisoning | 14.25 | 12.96 | 6 | 121665 | 12423 | 50471030 |
N-terminal prohormone brain natriuretic peptide abnormal | 14.17 | 12.96 | 5 | 121666 | 41 | 50483412 |
Carbon dioxide abnormal | 14.17 | 12.96 | 7 | 121664 | 142 | 50483311 |
Vasculitis | 14.15 | 12.96 | 8 | 121663 | 13983 | 50469470 |
Mydriasis | 14.14 | 12.96 | 4 | 121667 | 10623 | 50472830 |
Vascular device occlusion | 14.06 | 12.96 | 5 | 121666 | 42 | 50483411 |
Investigation | 14.06 | 12.96 | 18 | 121653 | 1534 | 50481919 |
Product complaint | 14.03 | 12.96 | 5 | 121666 | 11461 | 50471992 |
Muscle twitching | 13.99 | 12.96 | 10 | 121661 | 15421 | 50468032 |
Pulmonary arteriovenous fistula | 13.94 | 12.96 | 4 | 121667 | 15 | 50483438 |
Atrial pressure increased | 13.94 | 12.96 | 4 | 121667 | 15 | 50483438 |
Vitamin D deficiency | 13.91 | 12.96 | 5 | 121666 | 11397 | 50472056 |
Product prescribing error | 13.87 | 12.96 | 18 | 121653 | 20943 | 50462510 |
Premature delivery | 13.87 | 12.96 | 101 | 121570 | 23562 | 50459891 |
Joint effusion | 13.82 | 12.96 | 7 | 121664 | 13014 | 50470439 |
Cardiac procedure complication | 13.82 | 12.96 | 7 | 121664 | 150 | 50483303 |
Chest tube insertion | 13.76 | 12.96 | 5 | 121666 | 45 | 50483408 |
Vascular resistance pulmonary increased | 13.76 | 12.96 | 5 | 121666 | 45 | 50483408 |
Catheter site bruise | 13.75 | 12.96 | 9 | 121662 | 317 | 50483136 |
Decreased activity | 13.59 | 12.96 | 35 | 121636 | 5152 | 50478301 |
Cardiopulmonary failure | 13.59 | 12.96 | 27 | 121644 | 3346 | 50480107 |
Dysgeusia | 13.54 | 12.96 | 48 | 121623 | 38868 | 50444585 |
Abnormal dreams | 13.50 | 12.96 | 3 | 121668 | 9374 | 50474079 |
Respiratory depression | 13.45 | 12.96 | 6 | 121665 | 12004 | 50471449 |
Leukocytosis | 13.35 | 12.96 | 21 | 121650 | 22558 | 50460895 |
Psychomotor hyperactivity | 13.34 | 12.96 | 3 | 121668 | 9298 | 50474155 |
Pyelonephritis | 13.22 | 12.96 | 10 | 121661 | 14979 | 50468474 |
Eye irritation | 13.22 | 12.96 | 13 | 121658 | 17127 | 50466326 |
Suture related complication | 13.14 | 12.96 | 7 | 121664 | 167 | 50483286 |
Obstructive airways disorder | 13.11 | 12.96 | 11 | 121660 | 15641 | 50467812 |
Malignant melanoma | 13.09 | 12.96 | 4 | 121667 | 10104 | 50473349 |
Scar | 13.09 | 12.96 | 6 | 121665 | 11812 | 50471641 |
Mitral valve repair | 13.07 | 12.96 | 7 | 121664 | 169 | 50483284 |
Drug tolerance decreased | 13.05 | 12.96 | 3 | 121668 | 9157 | 50474296 |
Tuberculosis | 13.04 | 12.96 | 4 | 121667 | 10079 | 50473374 |
Abdominal pain | 13.03 | 12.96 | 451 | 121220 | 235777 | 50247676 |
Catheter site mass | 13.01 | 12.96 | 4 | 121667 | 20 | 50483433 |
Urinary tract infection | 12.98 | 12.96 | 425 | 121246 | 223595 | 50259858 |
Tooth disorder | 12.98 | 12.96 | 24 | 121647 | 24204 | 50459249 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Pulmonary arterial hypertension | 879.04 | 10.86 | 417 | 77317 | 7032 | 29489761 |
Pulmonary hypertension | 625.47 | 10.86 | 462 | 77272 | 18146 | 29478647 |
Right ventricular failure | 618.40 | 10.86 | 335 | 77399 | 7555 | 29489238 |
Fluid retention | 563.97 | 10.86 | 479 | 77255 | 23081 | 29473712 |
Dyspnoea | 441.19 | 10.86 | 1858 | 75876 | 324874 | 29171919 |
Headache | 399.15 | 10.86 | 1180 | 76554 | 172827 | 29323966 |
Pain in jaw | 388.73 | 10.86 | 288 | 77446 | 11353 | 29485440 |
Optic ischaemic neuropathy | 360.13 | 10.86 | 149 | 77585 | 1777 | 29495016 |
Cyanopsia | 324.15 | 10.86 | 77 | 77657 | 84 | 29496709 |
Death | 319.25 | 10.86 | 1750 | 75984 | 340334 | 29156459 |
Flushing | 249.65 | 10.86 | 343 | 77391 | 28649 | 29468144 |
Hypervolaemia | 237.82 | 10.86 | 261 | 77473 | 17284 | 29479509 |
Erection increased | 229.37 | 10.86 | 75 | 77659 | 427 | 29496366 |
Nasal congestion | 228.88 | 10.86 | 265 | 77469 | 18614 | 29478179 |
Febrile neutropenia | 206.33 | 10.86 | 26 | 77708 | 112214 | 29384579 |
Neutropenia | 198.08 | 10.86 | 51 | 77683 | 131660 | 29365133 |
Drug ineffective | 189.51 | 10.86 | 1611 | 76123 | 361559 | 29135234 |
Lung transplant | 187.96 | 10.86 | 92 | 77642 | 1664 | 29495129 |
Catheter management | 156.79 | 10.86 | 65 | 77669 | 779 | 29496014 |
Dyspnoea exertional | 155.80 | 10.86 | 315 | 77419 | 36175 | 29460618 |
Oxygen saturation decreased | 153.04 | 10.86 | 354 | 77380 | 44583 | 29452210 |
Malignant neoplasm progression | 151.77 | 10.86 | 11 | 77723 | 73848 | 29422945 |
Catheter site erythema | 140.35 | 10.86 | 67 | 77667 | 1144 | 29495649 |
Infusion site pain | 139.14 | 10.86 | 90 | 77644 | 2835 | 29493958 |
Catheterisation cardiac | 137.60 | 10.86 | 80 | 77654 | 2073 | 29494720 |
Blindness unilateral | 129.61 | 10.86 | 95 | 77639 | 3679 | 29493114 |
Transfusion | 126.67 | 10.86 | 124 | 77610 | 7174 | 29489619 |
Thrombocytopenia | 122.05 | 10.86 | 105 | 77629 | 134718 | 29362075 |
Acute kidney injury | 106.11 | 10.86 | 351 | 77383 | 264916 | 29231877 |
Prescription drug used without a prescription | 103.88 | 10.86 | 56 | 77678 | 1248 | 29495545 |
Erectile dysfunction | 99.95 | 10.86 | 174 | 77560 | 17835 | 29478958 |
Hospitalisation | 99.32 | 10.86 | 306 | 77428 | 45682 | 29451111 |
Oxygen consumption increased | 99.00 | 10.86 | 54 | 77680 | 1233 | 29495560 |
Suspected counterfeit product | 98.77 | 10.86 | 34 | 77700 | 232 | 29496561 |
Priapism | 98.67 | 10.86 | 87 | 77647 | 4401 | 29492392 |
Catheter placement | 98.14 | 10.86 | 44 | 77690 | 646 | 29496147 |
Visual impairment | 97.78 | 10.86 | 231 | 77503 | 29477 | 29467316 |
Leukopenia | 93.93 | 10.86 | 16 | 77718 | 55187 | 29441606 |
Oedema | 93.66 | 10.86 | 276 | 77458 | 40207 | 29456586 |
Condition aggravated | 93.32 | 10.86 | 681 | 77053 | 145614 | 29351179 |
Pulmonary arterial pressure increased | 90.34 | 10.86 | 48 | 77686 | 1038 | 29495755 |
Cardiac operation | 87.47 | 10.86 | 65 | 77669 | 2571 | 29494222 |
Catheter site pruritus | 86.18 | 10.86 | 32 | 77702 | 279 | 29496514 |
Toxicity to various agents | 84.59 | 10.86 | 209 | 77525 | 173452 | 29323341 |
Syncope | 83.78 | 10.86 | 429 | 77305 | 80942 | 29415851 |
Infusion site erythema | 83.61 | 10.86 | 53 | 77681 | 1611 | 29495182 |
Visual field defect | 83.01 | 10.86 | 76 | 77658 | 4040 | 29492753 |
Vision blurred | 80.93 | 10.86 | 261 | 77473 | 39915 | 29456878 |
Cardiac failure | 79.54 | 10.86 | 415 | 77319 | 78872 | 29417921 |
Chromatopsia | 78.72 | 10.86 | 27 | 77707 | 182 | 29496611 |
Catheter site discharge | 74.12 | 10.86 | 34 | 77700 | 528 | 29496265 |
Device related infection | 72.76 | 10.86 | 140 | 77594 | 15496 | 29481297 |
Pulmonary hypertensive crisis | 72.62 | 10.86 | 24 | 77710 | 142 | 29496651 |
Oedema peripheral | 71.76 | 10.86 | 492 | 77242 | 103065 | 29393728 |
Pyrexia | 70.05 | 10.86 | 456 | 77278 | 287166 | 29209627 |
Hypoxia | 68.33 | 10.86 | 276 | 77458 | 47103 | 29449690 |
Peyronie's disease | 66.85 | 10.86 | 18 | 77716 | 44 | 29496749 |
Palpitations | 66.73 | 10.86 | 213 | 77521 | 32391 | 29464402 |
Catheter site pain | 65.89 | 10.86 | 40 | 77694 | 1124 | 29495669 |
Dizziness | 64.61 | 10.86 | 772 | 76962 | 188912 | 29307881 |
Central venous catheterisation | 62.27 | 10.86 | 37 | 77697 | 999 | 29495794 |
Mucosal inflammation | 61.32 | 10.86 | 6 | 77728 | 31589 | 29465204 |
Device alarm issue | 60.82 | 10.86 | 30 | 77704 | 552 | 29496241 |
White blood cell count decreased | 60.68 | 10.86 | 78 | 77656 | 83284 | 29413509 |
Anaemia | 59.97 | 10.86 | 298 | 77436 | 200653 | 29296140 |
Pancytopenia | 59.32 | 10.86 | 79 | 77655 | 83089 | 29413704 |
Catheter site infection | 58.40 | 10.86 | 46 | 77688 | 1986 | 29494807 |
Neutrophil count decreased | 57.95 | 10.86 | 21 | 77713 | 43546 | 29453247 |
Device dislocation | 57.28 | 10.86 | 65 | 77669 | 4462 | 29492331 |
Heart transplant | 56.86 | 10.86 | 32 | 77702 | 778 | 29496015 |
Blindness | 56.36 | 10.86 | 108 | 77626 | 11915 | 29484878 |
Self-medication | 56.04 | 10.86 | 46 | 77688 | 2108 | 29494685 |
Retinal vein occlusion | 53.75 | 10.86 | 39 | 77695 | 1486 | 29495307 |
Cardiac disorder | 53.66 | 10.86 | 217 | 77517 | 37046 | 29459747 |
Electrocardiogram QT prolonged | 52.34 | 10.86 | 15 | 77719 | 36122 | 29460671 |
Counterfeit product administered | 52.27 | 10.86 | 19 | 77715 | 155 | 29496638 |
Infusion site haemorrhage | 52.05 | 10.86 | 29 | 77705 | 691 | 29496102 |
Pain in extremity | 51.94 | 10.86 | 480 | 77254 | 109953 | 29386840 |
Complication associated with device | 51.70 | 10.86 | 66 | 77668 | 5125 | 29491668 |
Hyponatraemia | 51.61 | 10.86 | 61 | 77673 | 67572 | 29429221 |
Chest pain | 51.31 | 10.86 | 484 | 77250 | 111489 | 29385304 |
Catheter site irritation | 50.96 | 10.86 | 17 | 77717 | 104 | 29496689 |
Catheter site rash | 50.45 | 10.86 | 19 | 77715 | 173 | 29496620 |
General physical health deterioration | 49.84 | 10.86 | 124 | 77610 | 102733 | 29394060 |
Thrombosis corpora cavernosa | 49.44 | 10.86 | 10 | 77724 | 0 | 29496793 |
Bone marrow failure | 48.85 | 10.86 | 7 | 77727 | 27442 | 29469351 |
Platelet count decreased | 48.55 | 10.86 | 129 | 77605 | 104543 | 29392250 |
Infusion site infection | 48.05 | 10.86 | 23 | 77711 | 395 | 29496398 |
Transplant evaluation | 47.73 | 10.86 | 24 | 77710 | 461 | 29496332 |
Pulmonary veno-occlusive disease | 46.44 | 10.86 | 23 | 77711 | 427 | 29496366 |
Product use in unapproved indication | 45.88 | 10.86 | 100 | 77634 | 86775 | 29410018 |
Catheter site swelling | 45.27 | 10.86 | 20 | 77714 | 283 | 29496510 |
Infusion related reaction | 44.99 | 10.86 | 30 | 77704 | 43856 | 29452937 |
C-reactive protein increased | 44.39 | 10.86 | 31 | 77703 | 44232 | 29452561 |
Deafness | 44.31 | 10.86 | 88 | 77646 | 9967 | 29486826 |
Deafness unilateral | 43.08 | 10.86 | 37 | 77697 | 1806 | 29494987 |
Peripheral swelling | 43.01 | 10.86 | 301 | 77433 | 63438 | 29433355 |
Pre-existing condition improved | 42.34 | 10.86 | 40 | 77694 | 2213 | 29494580 |
Ventilation perfusion mismatch | 42.18 | 10.86 | 13 | 77721 | 59 | 29496734 |
Completed suicide | 42.01 | 10.86 | 111 | 77623 | 90135 | 29406658 |
Blindness transient | 41.77 | 10.86 | 37 | 77697 | 1883 | 29494910 |
Cytomegalovirus infection | 41.12 | 10.86 | 6 | 77728 | 23209 | 29473584 |
Heart and lung transplant | 40.67 | 10.86 | 13 | 77721 | 68 | 29496725 |
Transient global amnesia | 40.35 | 10.86 | 19 | 77715 | 314 | 29496479 |
Concomitant disease aggravated | 39.98 | 10.86 | 57 | 77677 | 4921 | 29491872 |
Therapy change | 39.33 | 10.86 | 41 | 77693 | 2557 | 29494236 |
Renal impairment | 38.65 | 10.86 | 99 | 77635 | 81234 | 29415559 |
Spontaneous penile erection | 38.42 | 10.86 | 16 | 77718 | 194 | 29496599 |
Cardiac failure congestive | 38.08 | 10.86 | 337 | 77397 | 76244 | 29420549 |
Abdominal discomfort | 37.63 | 10.86 | 235 | 77499 | 47668 | 29449125 |
Dyschromatopsia | 37.61 | 10.86 | 18 | 77716 | 309 | 29496484 |
Off label use | 37.49 | 10.86 | 561 | 77173 | 300239 | 29196554 |
Hepatic function abnormal | 37.42 | 10.86 | 29 | 77705 | 39230 | 29457563 |
Rash maculo-papular | 37.23 | 10.86 | 9 | 77725 | 24280 | 29472513 |
Product counterfeit | 37.22 | 10.86 | 14 | 77720 | 127 | 29496666 |
Stomatitis | 37.20 | 10.86 | 26 | 77708 | 37087 | 29459706 |
Visual brightness | 36.98 | 10.86 | 10 | 77724 | 25 | 29496768 |
Vascular device infection | 36.97 | 10.86 | 39 | 77695 | 2466 | 29494327 |
Colitis | 36.84 | 10.86 | 18 | 77716 | 31230 | 29465563 |
Biopsy liver | 36.76 | 10.86 | 16 | 77718 | 218 | 29496575 |
Liver transplant | 35.87 | 10.86 | 37 | 77697 | 2279 | 29494514 |
Treatment failure | 35.57 | 10.86 | 27 | 77707 | 36912 | 29459881 |
Pulmonary oedema | 35.05 | 10.86 | 212 | 77522 | 42523 | 29454270 |
Ventricular assist device insertion | 34.99 | 10.86 | 9 | 77725 | 17 | 29496776 |
Pruritus | 34.95 | 10.86 | 173 | 77561 | 116676 | 29380117 |
Feeling abnormal | 34.92 | 10.86 | 254 | 77480 | 54191 | 29442602 |
Foetal exposure during pregnancy | 34.92 | 10.86 | 23 | 77711 | 33844 | 29462949 |
Retinal artery occlusion | 34.75 | 10.86 | 31 | 77703 | 1592 | 29495201 |
Dermatitis contact | 34.57 | 10.86 | 41 | 77693 | 2951 | 29493842 |
Malaise | 34.43 | 10.86 | 600 | 77134 | 159002 | 29337791 |
Spinal cord infarction | 34.11 | 10.86 | 16 | 77718 | 262 | 29496531 |
Lymphocyte count abnormal | 34.09 | 10.86 | 21 | 77713 | 606 | 29496187 |
Oxygen therapy | 33.92 | 10.86 | 22 | 77712 | 696 | 29496097 |
N-terminal prohormone brain natriuretic peptide increased | 33.85 | 10.86 | 33 | 77701 | 1899 | 29494894 |
Vascular resistance pulmonary increased | 33.72 | 10.86 | 9 | 77725 | 21 | 29496772 |
Device occlusion | 33.50 | 10.86 | 56 | 77678 | 5552 | 29491241 |
Brain natriuretic peptide increased | 33.33 | 10.86 | 48 | 77686 | 4182 | 29492611 |
Infusion site discharge | 33.32 | 10.86 | 12 | 77722 | 95 | 29496698 |
Infusion site swelling | 32.87 | 10.86 | 32 | 77702 | 1838 | 29494955 |
Confusional state | 32.41 | 10.86 | 200 | 77534 | 127677 | 29369116 |
Viral infection | 32.36 | 10.86 | 99 | 77635 | 14711 | 29482082 |
Cyanosis | 32.17 | 10.86 | 83 | 77651 | 11184 | 29485609 |
Hyperkalaemia | 32.13 | 10.86 | 71 | 77663 | 61321 | 29435472 |
Therapy non-responder | 31.78 | 10.86 | 163 | 77571 | 30748 | 29466045 |
Myalgia | 31.44 | 10.86 | 315 | 77419 | 73704 | 29423089 |
Disseminated intravascular coagulation | 31.42 | 10.86 | 7 | 77727 | 19973 | 29476820 |
Septic shock | 31.40 | 10.86 | 74 | 77660 | 62486 | 29434307 |
Biopsy lung | 31.14 | 10.86 | 12 | 77722 | 117 | 29496676 |
Painful erection | 31.13 | 10.86 | 14 | 77720 | 207 | 29496586 |
Paracentesis | 31.13 | 10.86 | 17 | 77717 | 389 | 29496404 |
Drug resistance | 31.08 | 10.86 | 9 | 77725 | 21531 | 29475262 |
Walking distance test abnormal | 31.05 | 10.86 | 13 | 77721 | 160 | 29496633 |
Dehydration | 30.91 | 10.86 | 176 | 77558 | 114572 | 29382221 |
Drug interaction | 30.84 | 10.86 | 351 | 77383 | 197034 | 29299759 |
Interstitial lung disease | 30.82 | 10.86 | 66 | 77668 | 57652 | 29439141 |
Eosinophilia | 30.64 | 10.86 | 10 | 77724 | 22151 | 29474642 |
Catheter site haemorrhage | 30.43 | 10.86 | 32 | 77702 | 2016 | 29494777 |
Visual acuity reduced | 30.25 | 10.86 | 97 | 77637 | 14779 | 29482014 |
Drug reaction with eosinophilia and systemic symptoms | 30.25 | 10.86 | 18 | 77716 | 27974 | 29468819 |
Medical device change | 30.23 | 10.86 | 11 | 77723 | 90 | 29496703 |
Tracheostomy | 30.20 | 10.86 | 20 | 77714 | 656 | 29496137 |
Pulmonary vein stenosis | 30.11 | 10.86 | 9 | 77725 | 36 | 29496757 |
Expired product administered | 30.00 | 10.86 | 37 | 77697 | 2774 | 29494019 |
Mechanical ventilation | 30.00 | 10.86 | 29 | 77705 | 1651 | 29495142 |
Metabolic acidosis | 29.77 | 10.86 | 33 | 77701 | 37629 | 29459164 |
Loss of visual contrast sensitivity | 29.66 | 10.86 | 6 | 77728 | 0 | 29496793 |
Drug abuse | 29.57 | 10.86 | 109 | 77625 | 79774 | 29417019 |
Scleroderma | 29.53 | 10.86 | 26 | 77708 | 1312 | 29495481 |
Thunderclap headache | 29.35 | 10.86 | 9 | 77725 | 40 | 29496753 |
Rheumatoid arthritis | 29.08 | 10.86 | 25 | 77709 | 32127 | 29464666 |
Pneumonitis | 28.97 | 10.86 | 19 | 77715 | 28025 | 29468768 |
Device connection issue | 28.75 | 10.86 | 15 | 77719 | 312 | 29496481 |
Fracture of penis | 28.56 | 10.86 | 13 | 77721 | 198 | 29496595 |
Delirium | 28.50 | 10.86 | 37 | 77697 | 39360 | 29457433 |
Catheter site inflammation | 28.39 | 10.86 | 13 | 77721 | 201 | 29496592 |
Right ventricular dysfunction | 28.31 | 10.86 | 22 | 77712 | 931 | 29495862 |
Therapeutic response unexpected | 28.22 | 10.86 | 67 | 77667 | 8571 | 29488222 |
Optic disc disorder | 28.01 | 10.86 | 9 | 77725 | 48 | 29496745 |
Exercise tolerance decreased | 27.64 | 10.86 | 44 | 77690 | 4187 | 29492606 |
Macrophages increased | 27.60 | 10.86 | 12 | 77722 | 163 | 29496630 |
Sepsis | 27.13 | 10.86 | 242 | 77492 | 142440 | 29354353 |
Product use issue | 26.92 | 10.86 | 229 | 77505 | 51215 | 29445578 |
Lactic acidosis | 26.78 | 10.86 | 24 | 77710 | 30223 | 29466570 |
Onychomycosis | 26.76 | 10.86 | 30 | 77704 | 2032 | 29494761 |
Multiple organ dysfunction syndrome | 26.16 | 10.86 | 82 | 77652 | 63034 | 29433759 |
Infusion site warmth | 25.64 | 10.86 | 10 | 77724 | 101 | 29496692 |
Aspiration pleural cavity | 25.58 | 10.86 | 19 | 77715 | 751 | 29496042 |
Osteonecrosis of jaw | 25.53 | 10.86 | 6 | 77728 | 16504 | 29480289 |
Penile curvature | 25.47 | 10.86 | 9 | 77725 | 67 | 29496726 |
Atrial septal defect repair | 25.46 | 10.86 | 10 | 77724 | 103 | 29496690 |
Rash | 25.34 | 10.86 | 349 | 77385 | 189470 | 29307323 |
Cor pulmonale | 25.06 | 10.86 | 18 | 77716 | 675 | 29496118 |
Hyperglycaemia | 25.01 | 10.86 | 32 | 77702 | 34255 | 29462538 |
Sinus congestion | 24.85 | 10.86 | 44 | 77690 | 4568 | 29492225 |
Hallucination | 24.82 | 10.86 | 50 | 77684 | 44662 | 29452131 |
Hypoglossal nerve paralysis | 24.72 | 10.86 | 5 | 77729 | 0 | 29496793 |
Plasma cell myeloma | 24.71 | 10.86 | 37 | 77697 | 37078 | 29459715 |
Device infusion issue | 24.69 | 10.86 | 17 | 77717 | 595 | 29496198 |
Neoplasm progression | 24.69 | 10.86 | 9 | 77725 | 18603 | 29478190 |
Product contamination | 24.52 | 10.86 | 17 | 77717 | 602 | 29496191 |
Cardiac index increased | 24.48 | 10.86 | 7 | 77727 | 23 | 29496770 |
Chorioretinopathy | 24.46 | 10.86 | 24 | 77710 | 1392 | 29495401 |
Infusion site discomfort | 24.41 | 10.86 | 10 | 77724 | 116 | 29496677 |
Somnolence | 24.28 | 10.86 | 146 | 77588 | 93809 | 29402984 |
Congestive hepatopathy | 24.08 | 10.86 | 26 | 77708 | 1688 | 29495105 |
Blood culture negative | 24.04 | 10.86 | 7 | 77727 | 25 | 29496768 |
Swelling | 24.01 | 10.86 | 167 | 77567 | 35116 | 29461677 |
Chronic obstructive pulmonary disease | 23.96 | 10.86 | 187 | 77547 | 40768 | 29456025 |
Patent ductus arteriosus repair | 23.81 | 10.86 | 6 | 77728 | 10 | 29496783 |
Ejaculation disorder | 23.78 | 10.86 | 20 | 77714 | 948 | 29495845 |
Tumour lysis syndrome | 23.66 | 10.86 | 4 | 77730 | 13880 | 29482913 |
Acute myeloid leukaemia | 23.64 | 10.86 | 7 | 77727 | 16506 | 29480287 |
Ejaculation failure | 23.42 | 10.86 | 18 | 77716 | 749 | 29496044 |
Catheter removal | 23.41 | 10.86 | 11 | 77723 | 181 | 29496612 |
Blood cholesterol increased | 23.39 | 10.86 | 92 | 77642 | 15503 | 29481290 |
Retinal vascular occlusion | 23.12 | 10.86 | 10 | 77724 | 134 | 29496659 |
Hepatotoxicity | 23.10 | 10.86 | 9 | 77725 | 17858 | 29478935 |
Retinal vascular disorder | 22.60 | 10.86 | 10 | 77724 | 142 | 29496651 |
Weight increased | 22.58 | 10.86 | 304 | 77430 | 76363 | 29420430 |
Anorgasmia | 22.48 | 10.86 | 16 | 77718 | 591 | 29496202 |
Pneumocystis jirovecii pneumonia | 22.45 | 10.86 | 8 | 77726 | 16771 | 29480022 |
Macular degeneration | 22.34 | 10.86 | 26 | 77708 | 1834 | 29494959 |
Dysphagia | 22.31 | 10.86 | 72 | 77662 | 54854 | 29441939 |
Cardiac ablation | 22.28 | 10.86 | 17 | 77717 | 700 | 29496093 |
Cardioversion | 22.00 | 10.86 | 18 | 77716 | 821 | 29495972 |
Balloon atrial septostomy | 21.91 | 10.86 | 6 | 77728 | 16 | 29496777 |
Infusion site scar | 21.84 | 10.86 | 7 | 77727 | 37 | 29496756 |
Blood testosterone decreased | 21.83 | 10.86 | 38 | 77696 | 3892 | 29492901 |
Maculopathy | 21.74 | 10.86 | 18 | 77716 | 835 | 29495958 |
Infusion site inflammation | 21.53 | 10.86 | 7 | 77727 | 39 | 29496754 |
Pneumonia aspiration | 21.33 | 10.86 | 40 | 77694 | 36697 | 29460096 |
Neuropathy peripheral | 21.31 | 10.86 | 105 | 77629 | 70922 | 29425871 |
Urticaria | 21.28 | 10.86 | 73 | 77661 | 54587 | 29442206 |
Inappropriate schedule of product administration | 21.21 | 10.86 | 54 | 77680 | 44418 | 29452375 |
Coma | 21.15 | 10.86 | 45 | 77689 | 39405 | 29457388 |
Optic atrophy | 21.13 | 10.86 | 17 | 77717 | 757 | 29496036 |
Macular oedema | 21.01 | 10.86 | 29 | 77705 | 2429 | 29494364 |
Hypotension | 20.85 | 10.86 | 663 | 77071 | 193691 | 29303102 |
Candida infection | 20.82 | 10.86 | 7 | 77727 | 15218 | 29481575 |
Dizziness exertional | 20.78 | 10.86 | 9 | 77725 | 121 | 29496672 |
Drug eruption | 20.73 | 10.86 | 9 | 77725 | 16732 | 29480061 |
Blood creatinine increased | 20.57 | 10.86 | 135 | 77599 | 84967 | 29411826 |
Sedation | 20.55 | 10.86 | 10 | 77724 | 17395 | 29479398 |
Cor pulmonale chronic | 20.43 | 10.86 | 7 | 77727 | 47 | 29496746 |
Catheterisation cardiac abnormal | 20.31 | 10.86 | 7 | 77727 | 48 | 29496745 |
Myoclonus | 20.26 | 10.86 | 5 | 77729 | 13304 | 29483489 |
Catheter site extravasation | 20.23 | 10.86 | 8 | 77726 | 84 | 29496709 |
Oxygen saturation abnormal | 20.21 | 10.86 | 20 | 77714 | 1172 | 29495621 |
Tinnitus | 20.18 | 10.86 | 88 | 77646 | 15526 | 29481267 |
Bronchopulmonary aspergillosis | 20.08 | 10.86 | 4 | 77730 | 12340 | 29484453 |
Respiratory syncytial virus infection | 19.83 | 10.86 | 35 | 77699 | 3624 | 29493169 |
Palmar-plantar erythrodysaesthesia syndrome | 19.81 | 10.86 | 7 | 77727 | 14752 | 29482041 |
Carbon dioxide increased | 19.67 | 10.86 | 18 | 77716 | 956 | 29495837 |
Infusion site irritation | 19.66 | 10.86 | 10 | 77724 | 197 | 29496596 |
Cough | 19.47 | 10.86 | 453 | 77281 | 126274 | 29370519 |
Penis disorder | 19.42 | 10.86 | 19 | 77715 | 1098 | 29495695 |
Carotid artery dissection | 19.26 | 10.86 | 9 | 77725 | 146 | 29496647 |
Acute respiratory failure | 19.17 | 10.86 | 127 | 77607 | 26275 | 29470518 |
Toxic epidermal necrolysis | 19.16 | 10.86 | 12 | 77722 | 18141 | 29478652 |
Lung disorder | 19.08 | 10.86 | 141 | 77593 | 30221 | 29466572 |
Genital swelling | 19.05 | 10.86 | 9 | 77725 | 150 | 29496643 |
Phlebotomy | 18.93 | 10.86 | 5 | 77729 | 11 | 29496782 |
Hypocalcaemia | 18.77 | 10.86 | 16 | 77718 | 20649 | 29476144 |
Rhabdomyolysis | 18.75 | 10.86 | 89 | 77645 | 60719 | 29436074 |
Abdominal pain | 18.72 | 10.86 | 247 | 77487 | 135110 | 29361683 |
Suture insertion | 18.67 | 10.86 | 6 | 77728 | 32 | 29496761 |
Neutropenic sepsis | 18.66 | 10.86 | 4 | 77730 | 11723 | 29485070 |
Micrococcus test positive | 18.63 | 10.86 | 5 | 77729 | 12 | 29496781 |
Implant site extravasation | 18.49 | 10.86 | 12 | 77722 | 380 | 29496413 |
Myelodysplastic syndrome | 18.45 | 10.86 | 12 | 77722 | 17782 | 29479011 |
Photopsia | 18.38 | 10.86 | 23 | 77711 | 1750 | 29495043 |
Stent placement | 18.15 | 10.86 | 37 | 77697 | 4269 | 29492524 |
Aspergillus infection | 18.14 | 10.86 | 3 | 77731 | 10578 | 29486215 |
Seizure | 18.10 | 10.86 | 157 | 77577 | 92966 | 29403827 |
Photophobia | 17.98 | 10.86 | 45 | 77689 | 5950 | 29490843 |
Haemophagocytic lymphohistiocytosis | 17.95 | 10.86 | 3 | 77731 | 10501 | 29486292 |
Conjunctival hyperaemia | 17.87 | 10.86 | 25 | 77709 | 2120 | 29494673 |
Sudden death | 17.84 | 10.86 | 79 | 77655 | 14031 | 29482762 |
Spontaneous intrahepatic portosystemic venous shunt | 17.83 | 10.86 | 5 | 77729 | 15 | 29496778 |
Hepatitis | 17.79 | 10.86 | 17 | 77717 | 20766 | 29476027 |
Rhinovirus infection | 17.74 | 10.86 | 31 | 77703 | 3185 | 29493608 |
Sudden cardiac death | 17.70 | 10.86 | 31 | 77703 | 3191 | 29493602 |
Full blood count decreased | 17.68 | 10.86 | 10 | 77724 | 15982 | 29480811 |
Polyneuropathy | 17.67 | 10.86 | 5 | 77729 | 12147 | 29484646 |
Lymphadenopathy | 17.63 | 10.86 | 24 | 77710 | 25025 | 29471768 |
Unevaluable event | 17.29 | 10.86 | 136 | 77598 | 29715 | 29467078 |
Device physical property issue | 17.25 | 10.86 | 14 | 77720 | 631 | 29496162 |
Pulmonary embolism | 17.21 | 10.86 | 124 | 77610 | 76410 | 29420383 |
Vitreous detachment | 17.05 | 10.86 | 15 | 77719 | 756 | 29496037 |
Decreased appetite | 17.03 | 10.86 | 274 | 77460 | 145068 | 29351725 |
Hyperbilirubinaemia | 17.00 | 10.86 | 9 | 77725 | 14925 | 29481868 |
Tracheitis | 16.92 | 10.86 | 14 | 77720 | 649 | 29496144 |
Hypophagia | 16.81 | 10.86 | 18 | 77716 | 20854 | 29475939 |
Psoriatic arthropathy | 16.51 | 10.86 | 9 | 77725 | 14682 | 29482111 |
Product quality issue | 16.46 | 10.86 | 84 | 77650 | 15811 | 29480982 |
Blood pressure abnormal | 16.36 | 10.86 | 47 | 77687 | 6743 | 29490050 |
Ocular vascular disorder | 16.33 | 10.86 | 8 | 77726 | 145 | 29496648 |
Heart rate increased | 16.17 | 10.86 | 165 | 77569 | 38773 | 29458020 |
Respiratory tract infection viral | 16.12 | 10.86 | 18 | 77716 | 1214 | 29495579 |
Therapy cessation | 16.09 | 10.86 | 78 | 77656 | 14384 | 29482409 |
Infusion site vesicles | 16.08 | 10.86 | 8 | 77726 | 150 | 29496643 |
Myelosuppression | 16.07 | 10.86 | 6 | 77728 | 12221 | 29484572 |
Blood ethanol increased | 16.05 | 10.86 | 12 | 77722 | 479 | 29496314 |
Hernia repair | 16.05 | 10.86 | 17 | 77717 | 1080 | 29495713 |
Presyncope | 15.95 | 10.86 | 84 | 77650 | 16005 | 29480788 |
Catheter site discolouration | 15.83 | 10.86 | 5 | 77729 | 25 | 29496768 |
Blood pressure decreased | 15.80 | 10.86 | 186 | 77548 | 45291 | 29451502 |
Lymphopenia | 15.64 | 10.86 | 8 | 77726 | 13525 | 29483268 |
Heart valve operation | 15.61 | 10.86 | 6 | 77728 | 58 | 29496735 |
Hypercalcaemia | 15.57 | 10.86 | 7 | 77727 | 12752 | 29484041 |
Contraindicated product administered | 15.57 | 10.86 | 15 | 77719 | 18251 | 29478542 |
Diuretic therapy | 15.51 | 10.86 | 5 | 77729 | 27 | 29496766 |
Chest discomfort | 15.51 | 10.86 | 187 | 77547 | 45796 | 29450997 |
Hypoacusis | 15.48 | 10.86 | 77 | 77657 | 14346 | 29482447 |
Pulmonary vascular resistance abnormality | 15.44 | 10.86 | 6 | 77728 | 60 | 29496733 |
Colour blindness | 15.42 | 10.86 | 9 | 77725 | 235 | 29496558 |
Chloropsia | 15.40 | 10.86 | 4 | 77730 | 8 | 29496785 |
Blood creatine phosphokinase increased | 15.33 | 10.86 | 55 | 77679 | 40589 | 29456204 |
Cardiac pacemaker insertion | 15.13 | 10.86 | 25 | 77709 | 2454 | 29494339 |
Dialysis | 15.13 | 10.86 | 60 | 77674 | 10148 | 29486645 |
Mobility decreased | 15.03 | 10.86 | 28 | 77706 | 25752 | 29471041 |
Papilloedema | 14.98 | 10.86 | 24 | 77710 | 2296 | 29494497 |
Acute right ventricular failure | 14.96 | 10.86 | 7 | 77727 | 114 | 29496679 |
Transplant rejection | 14.95 | 10.86 | 3 | 77731 | 9209 | 29487584 |
Viral labyrinthitis | 14.83 | 10.86 | 3 | 77731 | 0 | 29496793 |
Orchidopexy | 14.83 | 10.86 | 3 | 77731 | 0 | 29496793 |
Device leakage | 14.83 | 10.86 | 35 | 77699 | 4460 | 29492333 |
Therapeutic procedure | 14.81 | 10.86 | 8 | 77726 | 179 | 29496614 |
Catheter site scab | 14.79 | 10.86 | 4 | 77730 | 10 | 29496783 |
Thoracic cavity drainage | 14.69 | 10.86 | 8 | 77726 | 182 | 29496611 |
Encephalopathy | 14.57 | 10.86 | 38 | 77696 | 31005 | 29465788 |
Ileus | 14.55 | 10.86 | 10 | 77724 | 14392 | 29482401 |
Deafness transitory | 14.54 | 10.86 | 5 | 77729 | 34 | 29496759 |
Metastases to bone | 14.53 | 10.86 | 4 | 77730 | 9894 | 29486899 |
Pulmonary congestion | 14.51 | 10.86 | 68 | 77666 | 12368 | 29484425 |
Suicide attempt | 14.35 | 10.86 | 44 | 77690 | 34066 | 29462727 |
Dyskinesia | 14.34 | 10.86 | 19 | 77715 | 20042 | 29476751 |
Anaphylactic reaction | 14.32 | 10.86 | 32 | 77702 | 27541 | 29469252 |
Transplant | 14.31 | 10.86 | 13 | 77721 | 684 | 29496109 |
Basal cell carcinoma | 14.28 | 10.86 | 14 | 77720 | 16896 | 29479897 |
Device breakage | 14.14 | 10.86 | 20 | 77714 | 1714 | 29495079 |
Right ventricular dilatation | 14.11 | 10.86 | 12 | 77722 | 578 | 29496215 |
Oesophageal variceal ligation | 14.10 | 10.86 | 6 | 77728 | 77 | 29496716 |
Colour blindness acquired | 14.10 | 10.86 | 6 | 77728 | 77 | 29496716 |
Chronic respiratory failure | 14.10 | 10.86 | 17 | 77717 | 1245 | 29495548 |
Atrial flutter | 14.09 | 10.86 | 73 | 77661 | 13821 | 29482972 |
Pulmonary arterial pressure abnormal | 14.09 | 10.86 | 8 | 77726 | 198 | 29496595 |
Blood pressure fluctuation | 14.06 | 10.86 | 19 | 77715 | 19875 | 29476918 |
Peritonitis | 14.06 | 10.86 | 11 | 77723 | 14813 | 29481980 |
Hypokalaemia | 14.04 | 10.86 | 76 | 77658 | 50127 | 29446666 |
Lymphocyte count decreased | 14.04 | 10.86 | 18 | 77716 | 19253 | 29477540 |
Right atrial pressure increased | 14.04 | 10.86 | 6 | 77728 | 78 | 29496715 |
Penile vein thrombosis | 14.02 | 10.86 | 4 | 77730 | 13 | 29496780 |
Intentional product misuse | 13.98 | 10.86 | 146 | 77588 | 34515 | 29462278 |
Bradycardia | 13.95 | 10.86 | 108 | 77626 | 65521 | 29431272 |
Infusion site induration | 13.94 | 10.86 | 8 | 77726 | 202 | 29496591 |
Blood lactate dehydrogenase increased | 13.93 | 10.86 | 18 | 77716 | 19191 | 29477602 |
Road traffic accident | 13.92 | 10.86 | 79 | 77655 | 15482 | 29481311 |
Epstein-Barr virus antibody positive | 13.84 | 10.86 | 9 | 77725 | 286 | 29496507 |
Pulmonary arterial pressure decreased | 13.80 | 10.86 | 4 | 77730 | 14 | 29496779 |
Constipation | 13.77 | 10.86 | 214 | 77520 | 113946 | 29382847 |
Mineral supplementation | 13.77 | 10.86 | 6 | 77728 | 82 | 29496711 |
Vertebral artery stenosis | 13.76 | 10.86 | 7 | 77727 | 138 | 29496655 |
Substance use | 13.74 | 10.86 | 11 | 77723 | 486 | 29496307 |
Metastases to liver | 13.71 | 10.86 | 7 | 77727 | 11849 | 29484944 |
Retinal haemorrhage | 13.71 | 10.86 | 34 | 77700 | 4470 | 29492323 |
Chest tube insertion | 13.70 | 10.86 | 6 | 77728 | 83 | 29496710 |
Neurotoxicity | 13.66 | 10.86 | 11 | 77723 | 14602 | 29482191 |
Urinary tract infection | 13.61 | 10.86 | 123 | 77611 | 72231 | 29424562 |
Cardiac failure acute | 13.60 | 10.86 | 54 | 77680 | 9138 | 29487655 |
Epistaxis | 13.60 | 10.86 | 201 | 77533 | 51503 | 29445290 |
Pulmonary capillary haemangiomatosis | 13.58 | 10.86 | 4 | 77730 | 15 | 29496778 |
Endarterectomy | 13.58 | 10.86 | 7 | 77727 | 142 | 29496651 |
Injection site pain | 13.55 | 10.86 | 42 | 77692 | 32404 | 29464389 |
Vasodilatation | 13.46 | 10.86 | 15 | 77719 | 1009 | 29495784 |
Exposure during pregnancy | 13.44 | 10.86 | 3 | 77731 | 8551 | 29488242 |
Viral upper respiratory tract infection | 13.41 | 10.86 | 24 | 77710 | 2513 | 29494280 |
Loss of consciousness | 13.37 | 10.86 | 271 | 77463 | 73785 | 29423008 |
Depressed level of consciousness | 13.27 | 10.86 | 51 | 77683 | 36891 | 29459902 |
Food interaction | 13.26 | 10.86 | 14 | 77720 | 886 | 29495907 |
Bronchopulmonary dysplasia | 13.23 | 10.86 | 11 | 77723 | 513 | 29496280 |
Executive dysfunction | 13.20 | 10.86 | 8 | 77726 | 224 | 29496569 |
Product taste abnormal | 13.19 | 10.86 | 15 | 77719 | 1032 | 29495761 |
Hallucination, visual | 13.18 | 10.86 | 12 | 77722 | 15003 | 29481790 |
Renal tubular necrosis | 13.10 | 10.86 | 11 | 77723 | 14304 | 29482489 |
Altered state of consciousness | 13.07 | 10.86 | 20 | 77714 | 19869 | 29476924 |
Retinitis pigmentosa | 13.04 | 10.86 | 5 | 77729 | 48 | 29496745 |
Corneal abrasion | 12.98 | 10.86 | 8 | 77726 | 231 | 29496562 |
Glare | 12.97 | 10.86 | 6 | 77728 | 95 | 29496698 |
Transaminases increased | 12.87 | 10.86 | 25 | 77709 | 22637 | 29474156 |
Respiratory depression | 12.87 | 10.86 | 10 | 77724 | 13513 | 29483280 |
Retinopathy of prematurity | 12.86 | 10.86 | 6 | 77728 | 97 | 29496696 |
Nodular melanoma | 12.81 | 10.86 | 6 | 77728 | 98 | 29496695 |
Sudden hearing loss | 12.79 | 10.86 | 13 | 77721 | 787 | 29496006 |
Fasciectomy | 12.76 | 10.86 | 3 | 77731 | 3 | 29496790 |
Sensation of blood flow | 12.76 | 10.86 | 3 | 77731 | 3 | 29496790 |
Dyspepsia | 12.67 | 10.86 | 128 | 77606 | 29997 | 29466796 |
Libido decreased | 12.62 | 10.86 | 32 | 77702 | 4266 | 29492527 |
Male orgasmic disorder | 12.59 | 10.86 | 6 | 77728 | 102 | 29496691 |
Therapeutic product effect delayed | 12.59 | 10.86 | 15 | 77719 | 1085 | 29495708 |
Toxic skin eruption | 12.47 | 10.86 | 5 | 77729 | 9752 | 29487041 |
Deep vein thrombosis | 12.42 | 10.86 | 94 | 77640 | 57305 | 29439488 |
Emergency care | 12.37 | 10.86 | 8 | 77726 | 252 | 29496541 |
Exercise test abnormal | 12.30 | 10.86 | 3 | 77731 | 4 | 29496789 |
Right-to-left cardiac shunt | 12.28 | 10.86 | 5 | 77729 | 57 | 29496736 |
Retinal tear | 12.26 | 10.86 | 12 | 77722 | 694 | 29496099 |
Catheter site mass | 12.20 | 10.86 | 4 | 77730 | 23 | 29496770 |
Lung assist device therapy | 12.06 | 10.86 | 4 | 77730 | 24 | 29496769 |
Adulterated product | 12.06 | 10.86 | 4 | 77730 | 24 | 29496769 |
Cardiac discomfort | 12.04 | 10.86 | 10 | 77724 | 466 | 29496327 |
Hypomagnesaemia | 12.03 | 10.86 | 17 | 77717 | 17451 | 29479342 |
Vasculitis | 12.03 | 10.86 | 3 | 77731 | 7925 | 29488868 |
Retinal vein thrombosis | 11.96 | 10.86 | 9 | 77725 | 363 | 29496430 |
Gastrooesophageal reflux disease | 11.92 | 10.86 | 131 | 77603 | 31365 | 29465428 |
Infusion site abscess | 11.92 | 10.86 | 4 | 77730 | 25 | 29496768 |
Catheter site dermatitis | 11.90 | 10.86 | 3 | 77731 | 5 | 29496788 |
Hyperthermia | 11.78 | 10.86 | 5 | 77729 | 9425 | 29487368 |
Infusion site reaction | 11.73 | 10.86 | 12 | 77722 | 732 | 29496061 |
Glomerular filtration rate abnormal | 11.73 | 10.86 | 12 | 77722 | 732 | 29496061 |
Retinal infarction | 11.71 | 10.86 | 6 | 77728 | 120 | 29496673 |
Haematuria | 11.70 | 10.86 | 68 | 77666 | 44071 | 29452722 |
Hepatocellular injury | 11.58 | 10.86 | 24 | 77710 | 21219 | 29475574 |
Lymphocyte count | 11.56 | 10.86 | 5 | 77729 | 67 | 29496726 |
Micrococcus infection | 11.55 | 10.86 | 3 | 77731 | 6 | 29496787 |
Retinal disorder | 11.52 | 10.86 | 13 | 77721 | 887 | 29495906 |
Nephropathy toxic | 11.50 | 10.86 | 7 | 77727 | 10749 | 29486044 |
Prostate cancer | 11.49 | 10.86 | 110 | 77624 | 25417 | 29471376 |
Hypothyroidism | 11.44 | 10.86 | 15 | 77719 | 15891 | 29480902 |
Orgasm abnormal | 11.41 | 10.86 | 6 | 77728 | 127 | 29496666 |
Hypothermia | 11.38 | 10.86 | 5 | 77729 | 9234 | 29487559 |
Tricuspid valve incompetence | 11.38 | 10.86 | 48 | 77686 | 8346 | 29488447 |
Sinus disorder | 11.36 | 10.86 | 38 | 77696 | 5917 | 29490876 |
Accident at work | 11.31 | 10.86 | 11 | 77723 | 631 | 29496162 |
Vascular operation | 11.30 | 10.86 | 4 | 77730 | 30 | 29496763 |
Catheter site vesicles | 11.30 | 10.86 | 4 | 77730 | 30 | 29496763 |
Blood calcium decreased | 11.27 | 10.86 | 5 | 77729 | 9177 | 29487616 |
Melaena | 11.23 | 10.86 | 43 | 77691 | 31133 | 29465660 |
Ventricular dyskinesia | 11.18 | 10.86 | 7 | 77727 | 208 | 29496585 |
Gastrointestinal surgery | 11.18 | 10.86 | 4 | 77730 | 31 | 29496762 |
Product dose omission issue | 11.16 | 10.86 | 332 | 77402 | 96051 | 29400742 |
Psychotic disorder | 11.09 | 10.86 | 23 | 77711 | 20331 | 29476462 |
Haemoptysis | 11.08 | 10.86 | 126 | 77608 | 30424 | 29466369 |
Angioplasty | 11.05 | 10.86 | 13 | 77721 | 928 | 29495865 |
Internal haemorrhage | 11.02 | 10.86 | 31 | 77703 | 4396 | 29492397 |
Aggression | 10.97 | 10.86 | 52 | 77682 | 35489 | 29461304 |
Intentional overdose | 10.96 | 10.86 | 58 | 77676 | 38470 | 29458323 |
Mitral valve replacement | 10.88 | 10.86 | 6 | 77728 | 140 | 29496653 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Pulmonary arterial hypertension | 2948.28 | 11.26 | 1415 | 172129 | 23952 | 64301236 |
Dyspnoea | 2189.38 | 11.26 | 5471 | 168073 | 713203 | 63611985 |
Fluid retention | 2093.48 | 11.26 | 1533 | 172011 | 58073 | 64267115 |
Right ventricular failure | 1991.98 | 11.26 | 1028 | 172516 | 20443 | 64304745 |
Pulmonary hypertension | 1790.78 | 11.26 | 1229 | 172315 | 41910 | 64283278 |
Pain in jaw | 1509.60 | 11.26 | 1083 | 172461 | 39672 | 64285516 |
Death | 1326.01 | 11.26 | 3543 | 170001 | 479162 | 63846026 |
Hypervolaemia | 1031.58 | 11.26 | 842 | 172702 | 37443 | 64287745 |
Headache | 922.31 | 11.26 | 3318 | 170226 | 526149 | 63799039 |
Dyspnoea exertional | 822.67 | 11.26 | 1003 | 172541 | 72727 | 64252461 |
Catheter site erythema | 691.73 | 11.26 | 312 | 173232 | 4537 | 64320651 |
Lung transplant | 616.90 | 11.26 | 274 | 173270 | 3834 | 64321354 |
Nasal congestion | 598.93 | 11.26 | 770 | 172774 | 58888 | 64266300 |
Flushing | 575.65 | 11.26 | 872 | 172672 | 77776 | 64247412 |
Transfusion | 573.30 | 11.26 | 437 | 173107 | 17557 | 64307631 |
Oxygen saturation decreased | 547.12 | 11.26 | 1011 | 172533 | 106165 | 64219023 |
Oedema | 533.15 | 11.26 | 917 | 172627 | 91018 | 64234170 |
Catheter management | 488.51 | 11.26 | 219 | 173325 | 3136 | 64322052 |
Catheter site pruritus | 476.00 | 11.26 | 189 | 173355 | 1959 | 64323229 |
Device related infection | 473.60 | 11.26 | 494 | 173050 | 30132 | 64295056 |
Neutropenia | 438.54 | 11.26 | 62 | 173482 | 239562 | 64085626 |
Infusion site pain | 432.83 | 11.26 | 297 | 173247 | 10100 | 64315088 |
Catheter site pain | 426.14 | 11.26 | 218 | 173326 | 4244 | 64320944 |
Catheterisation cardiac | 422.15 | 11.26 | 223 | 173321 | 4650 | 64320538 |
Hospitalisation | 416.21 | 11.26 | 735 | 172809 | 74472 | 64250716 |
Toxicity to various agents | 399.66 | 11.26 | 242 | 173302 | 363271 | 63961917 |
Febrile neutropenia | 385.29 | 11.26 | 32 | 173512 | 187625 | 64137563 |
Catheter site discharge | 367.38 | 11.26 | 159 | 173385 | 2082 | 64323106 |
Chest pain | 358.85 | 11.26 | 1419 | 172125 | 234561 | 64090627 |
Pulmonary arterial pressure increased | 358.37 | 11.26 | 189 | 173355 | 3927 | 64321261 |
Oedema peripheral | 346.18 | 11.26 | 1297 | 172247 | 209020 | 64116168 |
Hypoxia | 342.19 | 11.26 | 742 | 172802 | 87407 | 64237781 |
Catheter site infection | 326.71 | 11.26 | 199 | 173345 | 5494 | 64319694 |
Infusion related reaction | 324.34 | 11.26 | 33 | 173511 | 164434 | 64160754 |
Syncope | 322.54 | 11.26 | 1045 | 172499 | 156590 | 64168598 |
Cardiac failure | 312.04 | 11.26 | 922 | 172622 | 131451 | 64193737 |
Oxygen consumption increased | 304.35 | 11.26 | 176 | 173368 | 4405 | 64320783 |
Completed suicide | 293.86 | 11.26 | 118 | 173426 | 224296 | 64100892 |
Catheter placement | 283.90 | 11.26 | 139 | 173405 | 2454 | 64322734 |
Central venous catheterisation | 276.58 | 11.26 | 139 | 173405 | 2602 | 64322586 |
Pulmonary oedema | 269.28 | 11.26 | 630 | 172914 | 78044 | 64247144 |
Infusion site erythema | 264.24 | 11.26 | 187 | 173357 | 6686 | 64318502 |
Condition aggravated | 248.84 | 11.26 | 1784 | 171760 | 370642 | 63954546 |
Malignant neoplasm progression | 246.86 | 11.26 | 14 | 173530 | 112857 | 64212331 |
Palpitations | 242.56 | 11.26 | 724 | 172820 | 103764 | 64221424 |
Device alarm issue | 239.44 | 11.26 | 112 | 173432 | 1778 | 64323410 |
Catheter site swelling | 239.22 | 11.26 | 107 | 173437 | 1523 | 64323665 |
Rheumatoid arthritis | 234.40 | 11.26 | 75 | 173469 | 164219 | 64160969 |
Drug interaction | 232.81 | 11.26 | 385 | 173159 | 361698 | 63963490 |
Cough | 231.89 | 11.26 | 1498 | 172046 | 300650 | 64024538 |
Dizziness | 227.49 | 11.26 | 1952 | 171592 | 428211 | 63896977 |
Alopecia | 221.99 | 11.26 | 84 | 173460 | 165606 | 64159582 |
Optic ischaemic neuropathy | 217.42 | 11.26 | 116 | 173428 | 2469 | 64322719 |
Cardiac disorder | 215.55 | 11.26 | 469 | 173075 | 55347 | 64269841 |
Treatment failure | 211.74 | 11.26 | 31 | 173513 | 116785 | 64208403 |
Contraindicated product administered | 209.04 | 11.26 | 23 | 173521 | 107806 | 64217382 |
Cardiac failure congestive | 207.73 | 11.26 | 797 | 172747 | 129783 | 64195405 |
Device leakage | 206.25 | 11.26 | 174 | 173370 | 8092 | 64317096 |
Scleroderma | 206.14 | 11.26 | 140 | 173404 | 4678 | 64320510 |
Drug hypersensitivity | 203.22 | 11.26 | 204 | 173340 | 237611 | 64087577 |
Infusion site infection | 201.31 | 11.26 | 94 | 173450 | 1486 | 64323702 |
Unevaluable event | 193.54 | 11.26 | 423 | 173121 | 50066 | 64275122 |
Cardiac operation | 191.21 | 11.26 | 127 | 173417 | 4087 | 64321101 |
Catheter site haemorrhage | 188.37 | 11.26 | 130 | 173414 | 4461 | 64320727 |
Rash | 187.56 | 11.26 | 621 | 172923 | 457928 | 63867260 |
Transplant evaluation | 187.20 | 11.26 | 89 | 173455 | 1468 | 64323720 |
Acute kidney injury | 184.69 | 11.26 | 607 | 172937 | 448633 | 63876555 |
Drug ineffective | 181.07 | 11.26 | 1423 | 172121 | 838824 | 63486364 |
Stomatitis | 175.19 | 11.26 | 40 | 173504 | 109565 | 64215623 |
Malaise | 166.17 | 11.26 | 1712 | 171832 | 394535 | 63930653 |
Catheter site rash | 163.49 | 11.26 | 70 | 173474 | 891 | 64324297 |
Concomitant disease aggravated | 162.16 | 11.26 | 177 | 173367 | 11365 | 64313823 |
Leukopenia | 161.70 | 11.26 | 37 | 173507 | 101205 | 64223983 |
Thrombocytopenia | 159.06 | 11.26 | 222 | 173322 | 223579 | 64101609 |
Joint swelling | 153.71 | 11.26 | 213 | 173331 | 215169 | 64110019 |
Product dose omission issue | 153.15 | 11.26 | 972 | 172572 | 193775 | 64131413 |
Hypotension | 151.69 | 11.26 | 1629 | 171915 | 379345 | 63945843 |
Device occlusion | 149.80 | 11.26 | 158 | 173386 | 9755 | 64315433 |
Complication associated with device | 148.63 | 11.26 | 193 | 173351 | 14887 | 64310301 |
Respiratory failure | 146.17 | 11.26 | 835 | 172709 | 160348 | 64164840 |
White blood cell count decreased | 145.84 | 11.26 | 126 | 173418 | 157711 | 64167477 |
Pulmonary veno-occlusive disease | 142.86 | 11.26 | 72 | 173472 | 1356 | 64323832 |
Catheter site irritation | 140.97 | 11.26 | 54 | 173490 | 504 | 64324684 |
Disease progression | 139.82 | 11.26 | 751 | 172793 | 140929 | 64184259 |
Pulmonary hypertensive crisis | 137.73 | 11.26 | 46 | 173498 | 275 | 64324913 |
Acute respiratory failure | 136.30 | 11.26 | 367 | 173177 | 49567 | 64275621 |
Mucosal inflammation | 136.09 | 11.26 | 8 | 173536 | 62576 | 64262612 |
Therapy change | 133.57 | 11.26 | 122 | 173422 | 6312 | 64318876 |
Off label use | 133.06 | 11.26 | 1078 | 172466 | 631728 | 63693460 |
Cyanopsia | 132.08 | 11.26 | 33 | 173511 | 50 | 64325138 |
Urticaria | 132.02 | 11.26 | 121 | 173423 | 147196 | 64177992 |
Pruritus | 131.07 | 11.26 | 418 | 173126 | 311982 | 64013206 |
Infusion site swelling | 130.13 | 11.26 | 112 | 173432 | 5353 | 64319835 |
Neutrophil count decreased | 129.87 | 11.26 | 25 | 173519 | 77171 | 64248017 |
Pneumonia | 127.88 | 11.26 | 2164 | 171380 | 557412 | 63767776 |
Musculoskeletal stiffness | 126.96 | 11.26 | 88 | 173456 | 123118 | 64202070 |
Electrocardiogram QT prolonged | 126.94 | 11.26 | 29 | 173515 | 79419 | 64245769 |
Arthropathy | 126.52 | 11.26 | 85 | 173459 | 120882 | 64204306 |
Glossodynia | 124.86 | 11.26 | 14 | 173530 | 64682 | 64260506 |
Drug abuse | 123.10 | 11.26 | 105 | 173439 | 132269 | 64192919 |
Catheter site inflammation | 122.81 | 11.26 | 57 | 173487 | 888 | 64324300 |
Device dislocation | 122.27 | 11.26 | 211 | 173333 | 20967 | 64304221 |
Pancytopenia | 121.11 | 11.26 | 124 | 173420 | 143185 | 64182003 |
Diarrhoea | 119.73 | 11.26 | 2661 | 170883 | 720043 | 63605145 |
Paracentesis | 118.73 | 11.26 | 61 | 173483 | 1198 | 64323990 |
Brain natriuretic peptide increased | 117.73 | 11.26 | 123 | 173421 | 7510 | 64317678 |
Device infusion issue | 115.34 | 11.26 | 67 | 173477 | 1691 | 64323497 |
Vascular device infection | 114.49 | 11.26 | 110 | 173434 | 6070 | 64319118 |
Confusional state | 113.33 | 11.26 | 344 | 173200 | 260800 | 64064388 |
N-terminal prohormone brain natriuretic peptide increased | 112.37 | 11.26 | 86 | 173458 | 3473 | 64321715 |
Pericarditis | 112.31 | 11.26 | 17 | 173527 | 62499 | 64262689 |
Hypersensitivity | 111.68 | 11.26 | 225 | 173319 | 196227 | 64128961 |
Therapeutic product effect decreased | 111.60 | 11.26 | 88 | 173456 | 115263 | 64209925 |
Hepatic enzyme increased | 111.44 | 11.26 | 111 | 173433 | 129832 | 64195356 |
Right ventricular dysfunction | 111.24 | 11.26 | 71 | 173473 | 2132 | 64323056 |
Erection increased | 109.59 | 11.26 | 40 | 173504 | 322 | 64324866 |
Product use in unapproved indication | 108.54 | 11.26 | 193 | 173351 | 176425 | 64148763 |
Exercise tolerance decreased | 107.90 | 11.26 | 118 | 173426 | 7592 | 64317596 |
Infusion site discharge | 105.83 | 11.26 | 44 | 173500 | 518 | 64324670 |
Epistaxis | 104.24 | 11.26 | 531 | 173013 | 97600 | 64227588 |
Injection site pain | 104.03 | 11.26 | 88 | 173456 | 111320 | 64213868 |
Myalgia | 103.93 | 11.26 | 757 | 172787 | 157860 | 64167328 |
Maternal exposure during pregnancy | 102.12 | 11.26 | 66 | 173478 | 95818 | 64229370 |
Oxygen therapy | 101.37 | 11.26 | 68 | 173476 | 2225 | 64322963 |
Dialysis | 100.87 | 11.26 | 171 | 173373 | 16749 | 64308439 |
Chest discomfort | 100.33 | 11.26 | 594 | 172950 | 115512 | 64209676 |
Dermatitis contact | 99.52 | 11.26 | 122 | 173422 | 8878 | 64316310 |
Cyanosis | 99.35 | 11.26 | 198 | 173346 | 21957 | 64303231 |
Hyponatraemia | 98.64 | 11.26 | 154 | 173390 | 148185 | 64177003 |
Ascites | 96.51 | 11.26 | 376 | 173168 | 61625 | 64263563 |
Rash maculo-papular | 96.48 | 11.26 | 8 | 173536 | 47018 | 64278170 |
Bone marrow failure | 96.10 | 11.26 | 9 | 173535 | 47943 | 64277245 |
Anaphylactic reaction | 94.98 | 11.26 | 33 | 173511 | 68631 | 64256557 |
Cardiac ablation | 94.20 | 11.26 | 59 | 173485 | 1713 | 64323475 |
Heart transplant | 93.72 | 11.26 | 52 | 173492 | 1199 | 64323989 |
Osteonecrosis of jaw | 93.46 | 11.26 | 3 | 173541 | 39822 | 64285366 |
Pain in extremity | 93.15 | 11.26 | 1234 | 172310 | 301851 | 64023337 |
Drug intolerance | 90.88 | 11.26 | 235 | 173309 | 187757 | 64137431 |
Cardiac pacemaker insertion | 90.40 | 11.26 | 88 | 173456 | 4935 | 64320253 |
Agranulocytosis | 89.29 | 11.26 | 3 | 173541 | 38226 | 64286962 |
Infusion site haemorrhage | 89.02 | 11.26 | 63 | 173481 | 2252 | 64322936 |
C-reactive protein increased | 88.57 | 11.26 | 75 | 173469 | 94834 | 64230354 |
Peripheral swelling | 88.53 | 11.26 | 906 | 172638 | 208247 | 64116941 |
Psoriasis | 88.50 | 11.26 | 41 | 173503 | 71662 | 64253526 |
Coma | 88.38 | 11.26 | 64 | 173480 | 87551 | 64237637 |
Feeling abnormal | 86.57 | 11.26 | 636 | 172908 | 132966 | 64192222 |
Pericardial effusion | 86.31 | 11.26 | 267 | 173277 | 38987 | 64286201 |
Presyncope | 85.99 | 11.26 | 248 | 173296 | 34841 | 64290347 |
Catheter site related reaction | 84.92 | 11.26 | 45 | 173499 | 944 | 64324244 |
Emergency care | 84.79 | 11.26 | 44 | 173500 | 883 | 64324305 |
Heart and lung transplant | 83.89 | 11.26 | 28 | 173516 | 167 | 64325021 |
Walking distance test abnormal | 83.15 | 11.26 | 40 | 173504 | 678 | 64324510 |
Therapy non-responder | 82.56 | 11.26 | 374 | 173170 | 65525 | 64259663 |
Cor pulmonale | 82.28 | 11.26 | 57 | 173487 | 1968 | 64323220 |
Abdominal distension | 82.21 | 11.26 | 490 | 173054 | 95504 | 64229684 |
Intentional overdose | 81.60 | 11.26 | 73 | 173471 | 89871 | 64235317 |
Erectile dysfunction | 81.15 | 11.26 | 132 | 173412 | 12495 | 64312693 |
Mobility decreased | 81.13 | 11.26 | 67 | 173477 | 85773 | 64239415 |
Drug reaction with eosinophilia and systemic symptoms | 80.44 | 11.26 | 23 | 173521 | 54194 | 64270994 |
Dyspnoea at rest | 80.24 | 11.26 | 92 | 173452 | 6237 | 64318951 |
Hypertension | 79.92 | 11.26 | 392 | 173152 | 258869 | 64066319 |
Psoriatic arthropathy | 77.22 | 11.26 | 12 | 173532 | 43269 | 64281919 |
Influenza | 77.11 | 11.26 | 521 | 173023 | 106010 | 64219178 |
Neoplasm progression | 76.25 | 11.26 | 10 | 173534 | 40954 | 64284234 |
Balloon atrial septostomy | 75.07 | 11.26 | 23 | 173521 | 99 | 64325089 |
Atrial flutter | 74.96 | 11.26 | 163 | 173381 | 19217 | 64305971 |
Tracheostomy | 74.32 | 11.26 | 43 | 173501 | 1077 | 64324111 |
Haemoptysis | 72.74 | 11.26 | 293 | 173251 | 48755 | 64276433 |
Injection site bruising | 72.43 | 11.26 | 7 | 173537 | 36366 | 64288822 |
Injection site erythema | 72.35 | 11.26 | 51 | 173493 | 70749 | 64254439 |
Overdose | 72.20 | 11.26 | 206 | 173338 | 159360 | 64165828 |
Mechanical ventilation | 71.89 | 11.26 | 56 | 173488 | 2322 | 64322866 |
Suicide attempt | 71.44 | 11.26 | 52 | 173492 | 70955 | 64254233 |
Lung disorder | 71.24 | 11.26 | 338 | 173206 | 60362 | 64264826 |
Heart rate increased | 71.07 | 11.26 | 482 | 173062 | 98193 | 64226995 |
Impaired healing | 70.96 | 11.26 | 37 | 173507 | 60436 | 64264752 |
Chronic obstructive pulmonary disease | 70.29 | 11.26 | 377 | 173167 | 70671 | 64254517 |
Rhabdomyolysis | 70.21 | 11.26 | 86 | 173458 | 91640 | 64233548 |
Blood pressure increased | 70.10 | 11.26 | 234 | 173310 | 172318 | 64152870 |
Catheter removal | 70.03 | 11.26 | 33 | 173511 | 533 | 64324655 |
Lactic acidosis | 69.97 | 11.26 | 39 | 173505 | 61371 | 64263817 |
Inappropriate schedule of product administration | 69.10 | 11.26 | 88 | 173456 | 92198 | 64232990 |
Sedation | 68.53 | 11.26 | 14 | 173530 | 41448 | 64283740 |
Delirium | 67.91 | 11.26 | 52 | 173492 | 69142 | 64256046 |
Atrial septal defect repair | 67.88 | 11.26 | 29 | 173515 | 367 | 64324821 |
Toxic epidermal necrolysis | 67.00 | 11.26 | 10 | 173534 | 37156 | 64288032 |
Neuropathy peripheral | 66.41 | 11.26 | 135 | 173409 | 117390 | 64207798 |
Lower respiratory tract infection | 66.00 | 11.26 | 95 | 173449 | 94519 | 64230669 |
Depressed level of consciousness | 65.94 | 11.26 | 73 | 173471 | 81363 | 64243825 |
Infusion site pruritus | 65.30 | 11.26 | 55 | 173489 | 2551 | 64322637 |
Medical device change | 65.30 | 11.26 | 30 | 173514 | 456 | 64324732 |
Injection site reaction | 65.27 | 11.26 | 22 | 173522 | 46642 | 64278546 |
Metabolic acidosis | 65.07 | 11.26 | 57 | 173487 | 70901 | 64254287 |
Congestive hepatopathy | 64.84 | 11.26 | 66 | 173478 | 3907 | 64321281 |
Drug resistance | 64.31 | 11.26 | 9 | 173535 | 35093 | 64290095 |
Sopor | 63.85 | 11.26 | 4 | 173540 | 29657 | 64295531 |
Device related sepsis | 63.78 | 11.26 | 74 | 173470 | 5081 | 64320107 |
Hallucination | 63.75 | 11.26 | 61 | 173483 | 72727 | 64252461 |
Therapeutic product effect incomplete | 63.61 | 11.26 | 113 | 173431 | 103369 | 64221819 |
Infusion site irritation | 63.59 | 11.26 | 29 | 173515 | 433 | 64324755 |
Catheter site vesicles | 63.08 | 11.26 | 26 | 173518 | 299 | 64324889 |
Cytomegalovirus infection | 62.66 | 11.26 | 12 | 173532 | 37187 | 64288001 |
Arthralgia | 62.42 | 11.26 | 827 | 172717 | 441433 | 63883755 |
Aspiration pleural cavity | 62.11 | 11.26 | 42 | 173502 | 1393 | 64323795 |
Folliculitis | 62.02 | 11.26 | 5 | 173539 | 30072 | 64295116 |
Blister | 61.88 | 11.26 | 76 | 173468 | 80891 | 64244297 |
Right ventricular dilatation | 61.84 | 11.26 | 42 | 173502 | 1403 | 64323785 |
Device connection issue | 61.68 | 11.26 | 35 | 173509 | 844 | 64324344 |
Oxygen saturation abnormal | 61.36 | 11.26 | 61 | 173483 | 3510 | 64321678 |
Helicobacter infection | 61.27 | 11.26 | 14 | 173530 | 38348 | 64286840 |
Device breakage | 61.05 | 11.26 | 95 | 173449 | 8660 | 64316528 |
Duodenal ulcer perforation | 60.87 | 11.26 | 10 | 173534 | 34615 | 64290573 |
Ventilation perfusion mismatch | 60.84 | 11.26 | 25 | 173519 | 285 | 64324903 |
Blood pressure decreased | 60.84 | 11.26 | 419 | 173125 | 85780 | 64239408 |
Drug-induced liver injury | 60.74 | 11.26 | 26 | 173518 | 47617 | 64277571 |
Suspected counterfeit product | 60.63 | 11.26 | 29 | 173515 | 485 | 64324703 |
Cardioversion | 60.50 | 11.26 | 46 | 173498 | 1839 | 64323349 |
Prescription drug used without a prescription | 59.31 | 11.26 | 52 | 173492 | 2548 | 64322640 |
Wound | 59.28 | 11.26 | 71 | 173473 | 76406 | 64248782 |
Stent placement | 59.16 | 11.26 | 74 | 173470 | 5497 | 64319691 |
Hyperglycaemia | 58.33 | 11.26 | 47 | 173497 | 60921 | 64264267 |
Biopsy liver | 58.17 | 11.26 | 29 | 173515 | 533 | 64324655 |
Hyperkalaemia | 57.27 | 11.26 | 116 | 173428 | 101013 | 64224175 |
Transplant | 56.38 | 11.26 | 33 | 173511 | 845 | 64324343 |
Palmar-plantar erythrodysaesthesia syndrome | 56.20 | 11.26 | 6 | 173538 | 28813 | 64296375 |
Viral infection | 56.09 | 11.26 | 219 | 173325 | 35921 | 64289267 |
Infusion site warmth | 55.25 | 11.26 | 35 | 173509 | 1037 | 64324151 |
Cognitive disorder | 54.56 | 11.26 | 41 | 173503 | 55046 | 64270142 |
Liver transplant | 54.45 | 11.26 | 61 | 173483 | 4031 | 64321157 |
Counterfeit product administered | 54.26 | 11.26 | 18 | 173526 | 105 | 64325083 |
Drug eruption | 54.21 | 11.26 | 15 | 173529 | 36121 | 64289067 |
Abdominal cavity drainage | 53.71 | 11.26 | 30 | 173514 | 701 | 64324487 |
Systemic scleroderma | 53.56 | 11.26 | 33 | 173511 | 930 | 64324258 |
Productive cough | 53.55 | 11.26 | 359 | 173185 | 72844 | 64252344 |
Device physical property issue | 53.41 | 11.26 | 45 | 173499 | 2088 | 64323100 |
Chronic respiratory failure | 53.28 | 11.26 | 49 | 173495 | 2557 | 64322631 |
Pneumocystis jirovecii pneumonia | 53.27 | 11.26 | 6 | 173538 | 27628 | 64297560 |
Right ventricular hypertrophy | 53.26 | 11.26 | 37 | 173507 | 1283 | 64323905 |
Pneumonitis | 53.16 | 11.26 | 35 | 173509 | 50330 | 64274858 |
Priapism | 52.52 | 11.26 | 59 | 173485 | 3911 | 64321277 |
Sleep disorder due to general medical condition, insomnia type | 52.45 | 11.26 | 5 | 173539 | 26265 | 64298923 |
Suicidal ideation | 52.40 | 11.26 | 61 | 173483 | 66481 | 64258707 |
Thrombosis in device | 51.69 | 11.26 | 66 | 173478 | 5005 | 64320183 |
Eosinophilia | 51.46 | 11.26 | 19 | 173525 | 38057 | 64287131 |
Lung assist device therapy | 50.85 | 11.26 | 17 | 173527 | 102 | 64325086 |
Disease complication | 50.84 | 11.26 | 60 | 173484 | 4195 | 64320993 |
Pulmonary arterial pressure abnormal | 50.57 | 11.26 | 28 | 173516 | 643 | 64324545 |
Acute myeloid leukaemia | 50.41 | 11.26 | 7 | 173537 | 27456 | 64297732 |
Catheter site extravasation | 49.98 | 11.26 | 23 | 173521 | 351 | 64324837 |
Hypocalcaemia | 49.80 | 11.26 | 25 | 173519 | 41728 | 64283460 |
Blindness unilateral | 49.44 | 11.26 | 75 | 173469 | 6686 | 64318502 |
Thrombosis corpora cavernosa | 49.21 | 11.26 | 10 | 173534 | 0 | 64325188 |
Serotonin syndrome | 49.19 | 11.26 | 22 | 173522 | 39260 | 64285928 |
Lymphocyte count decreased | 49.10 | 11.26 | 24 | 173520 | 40675 | 64284513 |
Catheterisation cardiac abnormal | 49.07 | 11.26 | 21 | 173523 | 267 | 64324921 |
General physical health deterioration | 48.56 | 11.26 | 336 | 173208 | 204089 | 64121099 |
Blood pressure fluctuation | 48.37 | 11.26 | 41 | 173503 | 51830 | 64273358 |
Infusion site abscess | 48.10 | 11.26 | 19 | 173525 | 194 | 64324994 |
Sinus congestion | 47.80 | 11.26 | 119 | 173425 | 15320 | 64309868 |
Neutropenic sepsis | 47.62 | 11.26 | 4 | 173540 | 23268 | 64301920 |
Infusion site induration | 47.49 | 11.26 | 29 | 173515 | 804 | 64324384 |
Terminal state | 47.14 | 11.26 | 59 | 173485 | 4385 | 64320803 |
Seizure | 47.08 | 11.26 | 260 | 173284 | 166632 | 64158556 |
Colitis | 47.05 | 11.26 | 53 | 173491 | 58621 | 64266567 |
Deep vein thrombosis | 46.68 | 11.26 | 137 | 173407 | 105045 | 64220143 |
Infusion site cellulitis | 46.61 | 11.26 | 20 | 173524 | 256 | 64324932 |
Internal haemorrhage | 46.38 | 11.26 | 78 | 173466 | 7589 | 64317599 |
Fibromyalgia | 46.35 | 11.26 | 19 | 173525 | 35712 | 64289476 |
Injection site pruritus | 46.10 | 11.26 | 22 | 173522 | 37804 | 64287384 |
Right ventricular systolic pressure increased | 46.09 | 11.26 | 29 | 173515 | 849 | 64324339 |
Blood culture negative | 46.07 | 11.26 | 18 | 173526 | 178 | 64325010 |
Rhinovirus infection | 46.03 | 11.26 | 69 | 173475 | 6087 | 64319101 |
Somnolence | 45.81 | 11.26 | 340 | 173204 | 203305 | 64121883 |
Blood creatine phosphokinase increased | 45.77 | 11.26 | 54 | 173490 | 58504 | 64266684 |
Osteoarthritis | 45.76 | 11.26 | 62 | 173482 | 63274 | 64261914 |
Concomitant disease progression | 45.69 | 11.26 | 50 | 173494 | 3219 | 64321969 |
Hepatocellular injury | 45.67 | 11.26 | 33 | 173511 | 45202 | 64279986 |
Dysphagia | 45.34 | 11.26 | 142 | 173402 | 106670 | 64218518 |
Inappropriate antidiuretic hormone secretion | 45.15 | 11.26 | 4 | 173540 | 22285 | 64302903 |
Catheter site scab | 45.04 | 11.26 | 18 | 173526 | 190 | 64324998 |
Blood pressure systolic increased | 45.01 | 11.26 | 40 | 173504 | 49413 | 64275775 |
Anaphylactic shock | 44.74 | 11.26 | 13 | 173531 | 30315 | 64294873 |
Myoclonus | 44.72 | 11.26 | 7 | 173537 | 25111 | 64300077 |
Vascular resistance pulmonary increased | 43.99 | 11.26 | 14 | 173530 | 70 | 64325118 |
Left-to-right cardiac shunt | 43.92 | 11.26 | 15 | 173529 | 97 | 64325091 |
Psychotic disorder | 43.87 | 11.26 | 19 | 173525 | 34559 | 64290629 |
Patent ductus arteriosus repair | 43.82 | 11.26 | 12 | 173532 | 31 | 64325157 |
Hernia repair | 43.71 | 11.26 | 37 | 173507 | 1728 | 64323460 |
Biopsy lung | 43.51 | 11.26 | 18 | 173526 | 209 | 64324979 |
Red blood cell sedimentation rate increased | 43.21 | 11.26 | 15 | 173529 | 31220 | 64293968 |
Platelet count decreased | 43.19 | 11.26 | 269 | 173275 | 167442 | 64157746 |
Basal cell carcinoma | 42.33 | 11.26 | 15 | 173529 | 30823 | 64294365 |
Blood culture positive | 42.32 | 11.26 | 76 | 173468 | 7792 | 64317396 |
Discomfort | 42.28 | 11.26 | 97 | 173447 | 80781 | 64244407 |
Pyrexia | 42.10 | 11.26 | 1163 | 172381 | 557481 | 63767707 |
Therapeutic response decreased | 42.00 | 11.26 | 47 | 173497 | 52141 | 64273047 |
Hypercalcaemia | 41.91 | 11.26 | 16 | 173528 | 31400 | 64293788 |
Polyneuropathy | 41.89 | 11.26 | 3 | 173541 | 19891 | 64305297 |
Intentional self-injury | 41.84 | 11.26 | 13 | 173531 | 29031 | 64296157 |
Carbon dioxide increased | 41.84 | 11.26 | 38 | 173506 | 1951 | 64323237 |
Neurotoxicity | 41.82 | 11.26 | 11 | 173533 | 27393 | 64297795 |
Hypoglycaemia | 41.42 | 11.26 | 115 | 173429 | 89777 | 64235411 |
Hepatitis | 41.33 | 11.26 | 37 | 173507 | 45545 | 64279643 |
Blood potassium decreased | 41.06 | 11.26 | 216 | 173328 | 40183 | 64285005 |
Gout | 41.05 | 11.26 | 139 | 173405 | 21274 | 64303914 |
Nausea | 40.95 | 11.26 | 2541 | 171003 | 783259 | 63541929 |
Irritable bowel syndrome | 40.77 | 11.26 | 25 | 173519 | 37344 | 64287844 |
Tumour lysis syndrome | 40.74 | 11.26 | 3 | 173541 | 19437 | 64305751 |
Catheter site warmth | 40.57 | 11.26 | 18 | 173526 | 251 | 64324937 |
Right-to-left cardiac shunt | 40.53 | 11.26 | 16 | 173528 | 163 | 64325025 |
Cardiac failure acute | 40.51 | 11.26 | 116 | 173428 | 16228 | 64308960 |
Pulmonary vascular resistance abnormality | 40.44 | 11.26 | 15 | 173529 | 127 | 64325061 |
Medication error | 40.21 | 11.26 | 45 | 173499 | 49921 | 64275267 |
Oral herpes | 39.84 | 11.26 | 6 | 173538 | 22146 | 64303042 |
Pulmonary congestion | 39.76 | 11.26 | 148 | 173396 | 23732 | 64301456 |
Inflammation | 39.50 | 11.26 | 72 | 173472 | 65228 | 64259960 |
Myelosuppression | 39.48 | 11.26 | 8 | 173536 | 23822 | 64301366 |
Heart valve operation | 39.13 | 11.26 | 16 | 173528 | 180 | 64325008 |
Altered state of consciousness | 39.12 | 11.26 | 27 | 173517 | 37875 | 64287313 |
Dizziness exertional | 39.02 | 11.26 | 21 | 173523 | 455 | 64324733 |
Dependence on oxygen therapy | 38.96 | 11.26 | 20 | 173524 | 392 | 64324796 |
Plasma cell myeloma | 38.75 | 11.26 | 40 | 173504 | 46035 | 64279153 |
Pulmonary vein stenosis | 38.69 | 11.26 | 15 | 173529 | 145 | 64325043 |
Infusion site oedema | 38.57 | 11.26 | 23 | 173521 | 610 | 64324578 |
Catheter site discolouration | 38.22 | 11.26 | 14 | 173530 | 114 | 64325074 |
Injection site swelling | 38.18 | 11.26 | 33 | 173511 | 41320 | 64283868 |
Sudden death | 38.13 | 11.26 | 130 | 173414 | 19966 | 64305222 |
Bradycardia | 37.98 | 11.26 | 176 | 173368 | 118043 | 64207145 |
Lymphopenia | 37.84 | 11.26 | 11 | 173533 | 25646 | 64299542 |
Infusion site rash | 37.74 | 11.26 | 28 | 173516 | 1078 | 64324110 |
Intentional product use issue | 37.57 | 11.26 | 131 | 173413 | 95233 | 64229955 |
Stevens-Johnson syndrome | 37.24 | 11.26 | 23 | 173521 | 34226 | 64290962 |
Endotracheal intubation | 37.06 | 11.26 | 49 | 173495 | 3846 | 64321342 |
Device malfunction | 36.97 | 11.26 | 118 | 173426 | 17515 | 64307673 |
Dyskinesia | 36.89 | 11.26 | 31 | 173513 | 39357 | 64285831 |
Myelodysplastic syndrome | 36.87 | 11.26 | 14 | 173530 | 27565 | 64297623 |
Respiratory distress | 36.69 | 11.26 | 254 | 173290 | 52077 | 64273111 |
Body temperature decreased | 36.65 | 11.26 | 12 | 173532 | 25916 | 64299272 |
Cholestasis | 36.57 | 11.26 | 40 | 173504 | 44832 | 64280356 |
Respiratory syncytial virus infection | 36.31 | 11.26 | 68 | 173476 | 7200 | 64317988 |
Central venous catheter removal | 36.23 | 11.26 | 19 | 173525 | 390 | 64324798 |
Pulmonary embolism | 36.02 | 11.26 | 238 | 173306 | 146118 | 64179070 |
Disease recurrence | 35.91 | 11.26 | 20 | 173524 | 31490 | 64293698 |
Finger amputation | 35.83 | 11.26 | 22 | 173522 | 616 | 64324572 |
Hallucination, visual | 35.78 | 11.26 | 15 | 173529 | 27819 | 64297369 |
Muscle rigidity | 35.76 | 11.26 | 3 | 173541 | 17470 | 64307718 |
Metastases to bone | 35.70 | 11.26 | 6 | 173538 | 20429 | 64304759 |
Ventricular septal defect repair | 35.68 | 11.26 | 10 | 173534 | 29 | 64325159 |
Paraesthesia | 35.55 | 11.26 | 214 | 173330 | 134308 | 64190880 |
Hypomagnesaemia | 35.52 | 11.26 | 29 | 173515 | 37347 | 64287841 |
Dizziness postural | 35.43 | 11.26 | 80 | 173464 | 9672 | 64315516 |
Nasopharyngitis | 35.42 | 11.26 | 732 | 172812 | 195341 | 64129847 |
Sinus disorder | 35.32 | 11.26 | 113 | 173431 | 16795 | 64308393 |
Acute right ventricular failure | 35.08 | 11.26 | 17 | 173527 | 293 | 64324895 |
Abortion spontaneous | 34.91 | 11.26 | 12 | 173532 | 25131 | 64300057 |
Hypokalaemia | 34.87 | 11.26 | 189 | 173355 | 121714 | 64203474 |
Systemic-pulmonary artery shunt | 34.71 | 11.26 | 10 | 173534 | 33 | 64325155 |
Cor pulmonale chronic | 34.55 | 11.26 | 16 | 173528 | 248 | 64324940 |
Orthostatic hypotension | 34.53 | 11.26 | 45 | 173499 | 46693 | 64278495 |
Peyronie's disease | 34.45 | 11.26 | 9 | 173535 | 18 | 64325170 |
Muscle injury | 34.39 | 11.26 | 14 | 173530 | 26423 | 64298765 |
Product supply issue | 34.34 | 11.26 | 29 | 173515 | 1350 | 64323838 |
Paranasal sinus hypersecretion | 34.28 | 11.26 | 42 | 173502 | 3054 | 64322134 |
Multiple sclerosis relapse | 34.26 | 11.26 | 36 | 173508 | 41099 | 64284089 |
Hypothyroidism | 34.16 | 11.26 | 35 | 173509 | 40422 | 64284766 |
Exposure during pregnancy | 33.86 | 11.26 | 102 | 173442 | 77573 | 64247615 |
Encephalopathy | 33.70 | 11.26 | 67 | 173477 | 58752 | 64266436 |
Aggression | 33.66 | 11.26 | 45 | 173499 | 46187 | 64279001 |
Haemophagocytic lymphohistiocytosis | 33.50 | 11.26 | 4 | 173540 | 17605 | 64307583 |
Asthma | 33.49 | 11.26 | 137 | 173407 | 95088 | 64230100 |
Disseminated intravascular coagulation | 33.44 | 11.26 | 23 | 173521 | 32325 | 64292863 |
Nephropathy toxic | 33.26 | 11.26 | 4 | 173540 | 17510 | 64307678 |
Visual field defect | 33.21 | 11.26 | 70 | 173474 | 8076 | 64317112 |
Osteoporosis | 32.67 | 11.26 | 39 | 173505 | 42041 | 64283147 |
Progressive multifocal leukoencephalopathy | 32.64 | 11.26 | 5 | 173539 | 18227 | 64306961 |
Suture insertion | 32.38 | 11.26 | 13 | 173531 | 139 | 64325049 |
Injection site discharge | 32.21 | 11.26 | 18 | 173526 | 421 | 64324767 |
Dysarthria | 32.07 | 11.26 | 70 | 173474 | 59336 | 64265852 |
Abdominal pain | 31.99 | 11.26 | 620 | 172924 | 311755 | 64013433 |
Seasonal allergy | 31.80 | 11.26 | 86 | 173458 | 11640 | 64313548 |
Posterior reversible encephalopathy syndrome | 31.77 | 11.26 | 11 | 173533 | 22935 | 64302253 |
Catheter site nodule | 31.59 | 11.26 | 10 | 173534 | 49 | 64325139 |
Peritonitis | 31.35 | 11.26 | 14 | 173530 | 25009 | 64300179 |
Gastrostomy | 31.34 | 11.26 | 24 | 173520 | 970 | 64324218 |
Osteopenia | 30.91 | 11.26 | 3 | 173541 | 15537 | 64309651 |
Right atrial pressure increased | 30.83 | 11.26 | 15 | 173529 | 261 | 64324927 |
Localised oedema | 30.73 | 11.26 | 63 | 173481 | 7128 | 64318060 |
Transplant rejection | 30.64 | 11.26 | 5 | 173539 | 17396 | 64307792 |
Metastases to liver | 30.62 | 11.26 | 13 | 173531 | 23928 | 64301260 |
Renal disorder | 30.56 | 11.26 | 181 | 173363 | 35184 | 64290004 |
Torsade de pointes | 30.55 | 11.26 | 5 | 173539 | 17358 | 64307830 |
Aspergillus infection | 30.48 | 11.26 | 4 | 173540 | 16375 | 64308813 |
Infusion site inflammation | 30.46 | 11.26 | 14 | 173530 | 213 | 64324975 |
Deafness unilateral | 30.39 | 11.26 | 43 | 173501 | 3599 | 64321589 |
Muscular weakness | 30.37 | 11.26 | 209 | 173335 | 127129 | 64198059 |
Rehabilitation therapy | 30.30 | 11.26 | 28 | 173516 | 1470 | 64323718 |
Pulmonary arterial pressure | 30.30 | 11.26 | 8 | 173536 | 17 | 64325171 |
Hypothermia | 30.24 | 11.26 | 8 | 173536 | 19848 | 64305340 |
Deafness | 29.92 | 11.26 | 113 | 173431 | 18246 | 64306942 |
Dystonia | 29.90 | 11.26 | 7 | 173537 | 18858 | 64306330 |
Arthritis | 29.84 | 11.26 | 120 | 173424 | 83694 | 64241494 |
Fracture of penis | 29.75 | 11.26 | 12 | 173532 | 130 | 64325058 |
Right ventricular enlargement | 29.67 | 11.26 | 18 | 173526 | 493 | 64324695 |
Systemic lupus erythematosus | 29.64 | 11.26 | 108 | 173436 | 77504 | 64247684 |
Proteinuria | 29.62 | 11.26 | 19 | 173525 | 27704 | 64297484 |
Respiratory depression | 29.55 | 11.26 | 13 | 173531 | 23430 | 64301758 |
Drug level increased | 29.54 | 11.26 | 29 | 173515 | 34167 | 64291021 |
Loss of visual contrast sensitivity | 29.52 | 11.26 | 6 | 173538 | 0 | 64325188 |
Angioplasty | 29.35 | 11.26 | 29 | 173515 | 1656 | 64323532 |
Agitation | 29.31 | 11.26 | 130 | 173414 | 88237 | 64236951 |
Skin lesion | 29.20 | 11.26 | 33 | 173511 | 36449 | 64288739 |
Renal impairment | 29.13 | 11.26 | 228 | 173316 | 134789 | 64190399 |
Heart disease congenital | 29.07 | 11.26 | 18 | 173526 | 512 | 64324676 |
Constipation | 29.03 | 11.26 | 438 | 173106 | 228899 | 64096289 |
Ill-defined disorder | 29.00 | 11.26 | 46 | 173498 | 44006 | 64281182 |
Toxic skin eruption | 28.94 | 11.26 | 8 | 173536 | 19276 | 64305912 |
Blood pressure abnormal | 28.82 | 11.26 | 95 | 173449 | 14340 | 64310848 |
Pulmonary artery aneurysm | 28.66 | 11.26 | 12 | 173532 | 144 | 64325044 |
Pulmonary arterial wedge pressure increased | 28.64 | 11.26 | 17 | 173527 | 447 | 64324741 |
Blood lactate dehydrogenase increased | 28.63 | 11.26 | 28 | 173516 | 33050 | 64292138 |
Infusion site vesicles | 28.53 | 11.26 | 16 | 173528 | 377 | 64324811 |
Skin exfoliation | 28.50 | 11.26 | 48 | 173496 | 44837 | 64280351 |
Foot deformity | 28.49 | 11.26 | 5 | 173539 | 16499 | 64308689 |
Bronchopulmonary aspergillosis | 28.48 | 11.26 | 8 | 173536 | 19077 | 64306111 |
Retching | 28.34 | 11.26 | 98 | 173446 | 15158 | 64310030 |
Epilepsy | 28.32 | 11.26 | 29 | 173515 | 33502 | 64291686 |
Cytopenia | 28.26 | 11.26 | 4 | 173540 | 15467 | 64309721 |
Weight increased | 28.26 | 11.26 | 763 | 172781 | 212585 | 64112603 |
Hospice care | 28.20 | 11.26 | 63 | 173481 | 7562 | 64317626 |
Painful erection | 28.15 | 11.26 | 12 | 173532 | 151 | 64325037 |
Echocardiogram abnormal | 27.90 | 11.26 | 29 | 173515 | 1760 | 64323428 |
Vascular resistance pulmonary decreased | 27.89 | 11.26 | 10 | 173534 | 76 | 64325112 |
Respiration abnormal | 27.78 | 11.26 | 56 | 173488 | 6259 | 64318929 |
Full blood count decreased | 27.72 | 11.26 | 13 | 173531 | 22569 | 64302619 |
Dialysis related complication | 27.70 | 11.26 | 13 | 173531 | 208 | 64324980 |
Cardiac index increased | 27.41 | 11.26 | 8 | 173536 | 28 | 64325160 |
Upper respiratory tract infection | 27.34 | 11.26 | 308 | 173236 | 72477 | 64252711 |
Cardiac output decreased | 27.25 | 11.26 | 28 | 173516 | 1676 | 64323512 |
Application site irritation | 27.22 | 11.26 | 27 | 173517 | 1549 | 64323639 |
Depression | 27.16 | 11.26 | 339 | 173205 | 182952 | 64142236 |
Product counterfeit | 27.10 | 11.26 | 13 | 173531 | 219 | 64324969 |
Angioedema | 27.07 | 11.26 | 81 | 173463 | 61740 | 64263448 |
Aplastic anaemia | 26.88 | 11.26 | 3 | 173541 | 13917 | 64311271 |
Wrong technique in product usage process | 26.44 | 11.26 | 88 | 173456 | 64886 | 64260302 |
Tracheostomy malfunction | 26.42 | 11.26 | 11 | 173533 | 130 | 64325058 |
Prescribed underdose | 26.07 | 11.26 | 8 | 173536 | 18007 | 64307181 |
Sleep study | 25.87 | 11.26 | 7 | 173537 | 17 | 64325171 |
Therapeutic embolisation | 25.84 | 11.26 | 16 | 173528 | 455 | 64324733 |
Acne | 25.80 | 11.26 | 15 | 173529 | 23066 | 64302122 |
Vasodilatation | 25.73 | 11.26 | 36 | 173508 | 2982 | 64322206 |
Accidental exposure to product | 25.62 | 11.26 | 20 | 173524 | 26344 | 64298844 |
Candida infection | 25.61 | 11.26 | 28 | 173516 | 31391 | 64293797 |
Application site pruritus | 25.51 | 11.26 | 39 | 173505 | 3500 | 64321688 |
Macrophages increased | 25.51 | 11.26 | 12 | 173532 | 193 | 64324995 |
Jugular vein distension | 25.38 | 11.26 | 24 | 173520 | 1298 | 64323890 |
Spinal cord infarction | 25.32 | 11.26 | 17 | 173527 | 557 | 64324631 |
Mouth ulceration | 25.26 | 11.26 | 30 | 173514 | 32414 | 64292774 |
Diagnostic procedure | 25.15 | 11.26 | 11 | 173533 | 148 | 64325040 |
Left ventricular failure | 25.14 | 11.26 | 64 | 173480 | 8353 | 64316835 |
Nocturnal dyspnoea | 25.07 | 11.26 | 24 | 173520 | 1318 | 64323870 |
Device issue | 25.04 | 11.26 | 124 | 173420 | 22524 | 64302664 |
Cardiomegaly | 25.01 | 11.26 | 128 | 173416 | 23556 | 64301632 |
Diabetic ketoacidosis | 24.99 | 11.26 | 26 | 173518 | 29819 | 64295369 |
Mineral supplementation | 24.81 | 11.26 | 19 | 173525 | 768 | 64324420 |
Transient global amnesia | 24.79 | 11.26 | 18 | 173526 | 670 | 64324518 |
Hypoaesthesia | 24.67 | 11.26 | 247 | 173297 | 138861 | 64186327 |
Head injury | 24.57 | 11.26 | 162 | 173382 | 32680 | 64292508 |
Injection site mass | 24.40 | 11.26 | 8 | 173536 | 17262 | 64307926 |
Leukocytosis | 24.29 | 11.26 | 40 | 173504 | 37700 | 64287488 |
Hepatic function abnormal | 24.23 | 11.26 | 90 | 173454 | 64223 | 64260965 |
CREST syndrome | 24.21 | 11.26 | 15 | 173529 | 427 | 64324761 |
Cavopulmonary anastomosis | 24.05 | 11.26 | 6 | 173538 | 9 | 64325179 |
Catheter site induration | 23.93 | 11.26 | 8 | 173536 | 48 | 64325140 |
Pulmonary pain | 23.81 | 11.26 | 32 | 173512 | 2552 | 64322636 |
Head discomfort | 23.73 | 11.26 | 78 | 173466 | 11756 | 64313432 |
Visual impairment | 23.68 | 11.26 | 304 | 173240 | 73773 | 64251415 |
Eczema | 23.66 | 11.26 | 27 | 173517 | 29693 | 64295495 |
Therapy cessation | 23.55 | 11.26 | 159 | 173385 | 32330 | 64292858 |
Pancreatitis acute | 23.54 | 11.26 | 50 | 173494 | 42805 | 64282383 |
Hereditary haemorrhagic telangiectasia | 23.45 | 11.26 | 7 | 173537 | 27 | 64325161 |
Parkinsonism | 23.45 | 11.26 | 5 | 173539 | 14368 | 64310820 |
Chest tube insertion | 23.45 | 11.26 | 10 | 173534 | 126 | 64325062 |
Hepatotoxicity | 23.34 | 11.26 | 45 | 173499 | 39917 | 64285271 |
Abnormal behaviour | 23.20 | 11.26 | 34 | 173510 | 33588 | 64291600 |
Haematuria | 23.19 | 11.26 | 84 | 173460 | 60387 | 64264801 |
Haemodynamic test abnormal | 23.13 | 11.26 | 8 | 173536 | 54 | 64325134 |
Pre-existing condition improved | 23.10 | 11.26 | 44 | 173500 | 4718 | 64320470 |
Paranasal sinus discomfort | 23.07 | 11.26 | 35 | 173509 | 3120 | 64322068 |
Device programming error | 23.04 | 11.26 | 9 | 173535 | 89 | 64325099 |
Thrombotic microangiopathy | 23.03 | 11.26 | 8 | 173536 | 16647 | 64308541 |
Catheter site mass | 23.00 | 11.26 | 8 | 173536 | 55 | 64325133 |
Multiple organ dysfunction syndrome | 22.93 | 11.26 | 169 | 173375 | 101244 | 64223944 |
Transaminases increased | 22.89 | 11.26 | 54 | 173490 | 44540 | 64280648 |
Vasculitis | 22.86 | 11.26 | 10 | 173534 | 18085 | 64307103 |
Blood calcium decreased | 22.86 | 11.26 | 21 | 173523 | 25533 | 64299655 |
Orthopnoea | 22.80 | 11.26 | 65 | 173479 | 9069 | 64316119 |
Hypoacusis | 22.74 | 11.26 | 133 | 173411 | 25734 | 64299454 |
Chemotherapy | 22.73 | 11.26 | 24 | 173520 | 1483 | 64323705 |
Dysentery | 22.71 | 11.26 | 19 | 173525 | 873 | 64324315 |
Delusion | 22.69 | 11.26 | 10 | 173534 | 18004 | 64307184 |
Cardiorenal syndrome | 22.68 | 11.26 | 22 | 173522 | 1228 | 64323960 |
Injury | 22.67 | 11.26 | 76 | 173468 | 55916 | 64269272 |
Treatment noncompliance | 22.67 | 11.26 | 197 | 173347 | 43285 | 64281903 |
Multiple allergies | 22.59 | 11.26 | 49 | 173495 | 5765 | 64319423 |
Chromatopsia | 22.58 | 11.26 | 16 | 173528 | 573 | 64324615 |
Bursitis | 22.58 | 11.26 | 15 | 173529 | 21470 | 64303718 |
Rash erythematous | 22.56 | 11.26 | 62 | 173482 | 48571 | 64276617 |
Renal tubular necrosis | 22.48 | 11.26 | 16 | 173528 | 22094 | 64303094 |
Staphylococcus test positive | 22.42 | 11.26 | 48 | 173496 | 5597 | 64319591 |
Penile curvature | 22.34 | 11.26 | 6 | 173538 | 14 | 64325174 |
Anti factor VIII antibody test | 22.26 | 11.26 | 5 | 173539 | 3 | 64325185 |
Coronary artery compression | 22.26 | 11.26 | 5 | 173539 | 3 | 64325185 |
Self-medication | 22.24 | 11.26 | 40 | 173504 | 4105 | 64321083 |
Diet noncompliance | 22.21 | 11.26 | 14 | 173530 | 411 | 64324777 |
Dyschromatopsia | 22.16 | 11.26 | 17 | 173527 | 689 | 64324499 |
Atrial fibrillation | 22.12 | 11.26 | 610 | 172934 | 170479 | 64154709 |
Obstructive airways disorder | 22.02 | 11.26 | 18 | 173526 | 23167 | 64302021 |
Hypoalbuminaemia | 21.97 | 11.26 | 10 | 173534 | 17664 | 64307524 |
Phlebotomy | 21.77 | 11.26 | 6 | 173538 | 16 | 64325172 |
Diuretic therapy | 21.71 | 11.26 | 10 | 173534 | 153 | 64325035 |
Metastases to lung | 21.69 | 11.26 | 7 | 173537 | 15257 | 64309931 |
Tracheostomy tube removal | 21.68 | 11.26 | 5 | 173539 | 4 | 64325184 |
Psychomotor hyperactivity | 21.67 | 11.26 | 6 | 173538 | 14445 | 64310743 |
Hypertensive crisis | 21.65 | 11.26 | 11 | 173533 | 18237 | 64306951 |
Retinal vein occlusion | 21.64 | 11.26 | 33 | 173511 | 2955 | 64322233 |
Ileus | 21.60 | 11.26 | 18 | 173526 | 22948 | 64302240 |
Catheter site dryness | 21.52 | 11.26 | 7 | 173537 | 38 | 64325150 |
Grip strength decreased | 21.49 | 11.26 | 3 | 173541 | 11721 | 64313467 |
Blood glucose increased | 21.43 | 11.26 | 165 | 173379 | 97908 | 64227280 |
Herpes zoster | 21.43 | 11.26 | 125 | 173419 | 79062 | 64246126 |
Gastrointestinal tube insertion | 21.40 | 11.26 | 23 | 173521 | 1451 | 64323737 |
Pulmonary artery dilatation | 21.30 | 11.26 | 13 | 173531 | 360 | 64324828 |
Encephalitis | 21.29 | 11.26 | 4 | 173540 | 12567 | 64312621 |
Pulmonary valve replacement | 21.26 | 11.26 | 6 | 173538 | 18 | 64325170 |
Pulmonary arterial pressure decreased | 21.20 | 11.26 | 9 | 173535 | 112 | 64325076 |
Loss of consciousness | 21.20 | 11.26 | 536 | 173008 | 147829 | 64177359 |
Respiratory disorder | 21.17 | 11.26 | 168 | 173376 | 35943 | 64289245 |
Spontaneous penile erection | 21.13 | 11.26 | 9 | 173535 | 113 | 64325075 |
Labelled drug-drug interaction medication error | 21.11 | 11.26 | 17 | 173527 | 22045 | 64303143 |
Immune reconstitution inflammatory syndrome | 21.05 | 11.26 | 4 | 173540 | 12466 | 64312722 |
Incorrect route of product administration | 21.01 | 11.26 | 19 | 173525 | 23279 | 64301909 |
Akathisia | 20.97 | 11.26 | 3 | 173541 | 11507 | 64313681 |
Rhinorrhoea | 20.84 | 11.26 | 250 | 173294 | 59719 | 64265469 |
Blood iron decreased | 20.84 | 11.26 | 76 | 173468 | 12066 | 64313122 |
Speech disorder | 20.83 | 11.26 | 64 | 173480 | 48377 | 64276811 |
Erythema | 20.78 | 11.26 | 366 | 173178 | 186704 | 64138484 |
Poisoning | 20.76 | 11.26 | 17 | 173527 | 21862 | 64303326 |
Generalised tonic-clonic seizure | 20.67 | 11.26 | 48 | 173496 | 39809 | 64285379 |
Tubulointerstitial nephritis | 20.61 | 11.26 | 32 | 173512 | 30877 | 64294311 |
Hyperthermia | 20.61 | 11.26 | 8 | 173536 | 15542 | 64309646 |
Gastritis hypertrophic | 20.53 | 11.26 | 7 | 173537 | 45 | 64325143 |
Disorientation | 20.46 | 11.26 | 79 | 173465 | 55749 | 64269439 |
Metastases to central nervous system | 20.45 | 11.26 | 6 | 173538 | 13906 | 64311282 |
Urinary tract infection | 20.37 | 11.26 | 471 | 173073 | 231125 | 64094063 |
Product prescribing error | 20.35 | 11.26 | 40 | 173504 | 35229 | 64289959 |
Enterococcal infection | 20.35 | 11.26 | 6 | 173538 | 13860 | 64311328 |
Nasal dryness | 20.18 | 11.26 | 35 | 173509 | 3491 | 64321697 |
Congenital arterial malformation | 20.13 | 11.26 | 6 | 173538 | 23 | 64325165 |
Bone disorder | 20.04 | 11.26 | 10 | 173534 | 16749 | 64308439 |
Cardiac output increased | 20 | 11.26 | 10 | 173534 | 185 | 64325003 |
Body temperature increased | 19.96 | 11.26 | 43 | 173501 | 36623 | 64288565 |
Atrial tachycardia | 19.94 | 11.26 | 35 | 173509 | 3524 | 64321664 |
Ataxia | 19.93 | 11.26 | 18 | 173526 | 22066 | 64303122 |
Choking | 19.84 | 11.26 | 68 | 173476 | 10470 | 64314718 |
Oxygen consumption | 19.80 | 11.26 | 8 | 173536 | 87 | 64325101 |
Penile vein thrombosis | 19.68 | 11.26 | 4 | 173540 | 0 | 64325188 |
Increased ventricular preload | 19.68 | 11.26 | 4 | 173540 | 0 | 64325188 |
Catheter culture positive | 19.62 | 11.26 | 10 | 173534 | 193 | 64324995 |
Pericardial drainage | 19.61 | 11.26 | 12 | 173532 | 334 | 64324854 |
Blood bilirubin increased | 19.60 | 11.26 | 239 | 173305 | 57314 | 64267874 |
Pulmonary capillary haemangiomatosis | 19.55 | 11.26 | 7 | 173537 | 53 | 64325135 |
Tenosynovitis | 19.54 | 11.26 | 4 | 173540 | 11829 | 64313359 |
Infusion site reaction | 19.47 | 11.26 | 26 | 173518 | 2060 | 64323128 |
Pain | 19.47 | 11.26 | 1256 | 172288 | 552255 | 63772933 |
Infective pulmonary exacerbation of cystic fibrosis | 19.46 | 11.26 | 4 | 173540 | 11792 | 64313396 |
Therapeutic procedure | 19.39 | 11.26 | 16 | 173528 | 721 | 64324467 |
Injection site haemorrhage | 19.39 | 11.26 | 22 | 173522 | 24256 | 64300932 |
Disturbance in attention | 19.32 | 11.26 | 52 | 173492 | 41022 | 64284166 |
Cytomegalovirus viraemia | 19.32 | 11.26 | 3 | 173541 | 10825 | 64314363 |
Type 2 diabetes mellitus | 19.27 | 11.26 | 39 | 173505 | 33981 | 64291207 |
Septic shock | 19.20 | 11.26 | 186 | 173358 | 105251 | 64219937 |
Pneumonia aspiration | 19.17 | 11.26 | 88 | 173456 | 59183 | 64266005 |
Ejaculation failure | 19.14 | 11.26 | 12 | 173532 | 349 | 64324839 |
Haemorrhage | 19.13 | 11.26 | 310 | 173234 | 79041 | 64246147 |
Sinus bradycardia | 19.11 | 11.26 | 20 | 173524 | 22873 | 64302315 |
Liver function test abnormal | 19.08 | 11.26 | 244 | 173300 | 59157 | 64266031 |
Application site odour | 19.02 | 11.26 | 6 | 173538 | 29 | 64325159 |
Catheter site abscess | 19.02 | 11.26 | 6 | 173538 | 29 | 64325159 |
Infusion site discolouration | 18.89 | 11.26 | 14 | 173530 | 538 | 64324650 |
Joint stiffness | 18.85 | 11.26 | 33 | 173511 | 30371 | 64294817 |
Choking sensation | 18.82 | 11.26 | 34 | 173510 | 3501 | 64321687 |
Oral pain | 18.78 | 11.26 | 28 | 173516 | 27465 | 64297723 |
Ammonia increased | 18.75 | 11.26 | 51 | 173493 | 6926 | 64318262 |
Product administration interrupted | 18.75 | 11.26 | 19 | 173525 | 1119 | 64324069 |
Ear tube insertion | 18.67 | 11.26 | 8 | 173536 | 102 | 64325086 |
Hepatic cirrhosis | 18.64 | 11.26 | 128 | 173416 | 26170 | 64299018 |
Herpes simplex | 18.61 | 11.26 | 3 | 173541 | 10533 | 64314655 |
Micrococcus test positive | 18.52 | 11.26 | 5 | 173539 | 12 | 64325176 |
Respiratory therapy | 18.52 | 11.26 | 5 | 173539 | 12 | 64325176 |
Tracheitis | 18.50 | 11.26 | 20 | 173524 | 1270 | 64323918 |
Tuberculosis | 18.49 | 11.26 | 6 | 173538 | 13032 | 64312156 |
Peripheral sensory neuropathy | 18.48 | 11.26 | 4 | 173540 | 11374 | 64313814 |
Arteriovenous malformation | 18.46 | 11.26 | 22 | 173522 | 1554 | 64323634 |
Expired product administered | 18.38 | 11.26 | 46 | 173498 | 5941 | 64319247 |
Cardiac flutter | 18.25 | 11.26 | 37 | 173507 | 4152 | 64321036 |
Loss of personal independence in daily activities | 18.23 | 11.26 | 117 | 173427 | 72337 | 64252851 |
Purpura | 18.18 | 11.26 | 12 | 173532 | 17234 | 64307954 |
Enteritis | 18.14 | 11.26 | 5 | 173539 | 12072 | 64313116 |
Hypertriglyceridaemia | 18.07 | 11.26 | 4 | 173540 | 11201 | 64313987 |
COVID-19 | 18.07 | 11.26 | 102 | 173442 | 65038 | 64260150 |
Hypogammaglobulinaemia | 18.04 | 11.26 | 3 | 173541 | 10296 | 64314892 |
Injection site urticaria | 18.02 | 11.26 | 4 | 173540 | 11177 | 64314011 |
Pleural effusion | 18.01 | 11.26 | 457 | 173087 | 126102 | 64199086 |
Blood creatinine increased | 17.97 | 11.26 | 257 | 173287 | 135525 | 64189663 |
Product use issue | 17.97 | 11.26 | 535 | 173009 | 151180 | 64174008 |
Exercise test abnormal | 17.94 | 11.26 | 7 | 173537 | 69 | 64325119 |
Injection site rash | 17.92 | 11.26 | 10 | 173534 | 15732 | 64309456 |
Tracheostomy infection | 17.76 | 11.26 | 7 | 173537 | 71 | 64325117 |
Immunoglobulin G4 related disease | 17.75 | 11.26 | 8 | 173536 | 116 | 64325072 |
Spontaneous intrahepatic portosystemic venous shunt | 17.71 | 11.26 | 5 | 173539 | 15 | 64325173 |
Large intestine perforation | 17.52 | 11.26 | 6 | 173538 | 12598 | 64312590 |
Heart valve replacement | 17.50 | 11.26 | 15 | 173529 | 713 | 64324475 |
Skin operation | 17.47 | 11.26 | 5 | 173539 | 16 | 64325172 |
Radiotherapy | 17.43 | 11.26 | 12 | 173532 | 410 | 64324778 |
Emotional distress | 17.43 | 11.26 | 45 | 173499 | 35993 | 64289195 |
Large intestinal polypectomy | 17.30 | 11.26 | 10 | 173534 | 250 | 64324938 |
Biopsy bone marrow | 17.18 | 11.26 | 11 | 173533 | 332 | 64324856 |
Osteonecrosis | 17.18 | 11.26 | 31 | 173513 | 28198 | 64296990 |
Pneumothorax | 17.07 | 11.26 | 118 | 173426 | 24180 | 64301008 |
Cardiac failure high output | 17.05 | 11.26 | 10 | 173534 | 257 | 64324931 |
Mitral valve replacement | 17.04 | 11.26 | 11 | 173533 | 337 | 64324851 |
Withdrawal syndrome | 16.96 | 11.26 | 23 | 173521 | 23469 | 64301719 |
Nodule | 16.96 | 11.26 | 14 | 173530 | 17933 | 64307255 |
Pyelonephritis | 16.90 | 11.26 | 13 | 173531 | 17253 | 64307935 |
Decreased activity | 16.87 | 11.26 | 50 | 173494 | 7130 | 64318058 |
Device difficult to use | 16.85 | 11.26 | 3 | 173541 | 9795 | 64315393 |
Restlessness | 16.80 | 11.26 | 53 | 173491 | 39732 | 64285456 |
Catheter site dermatitis | 16.79 | 11.26 | 7 | 173537 | 83 | 64325105 |
Tricuspid valve incompetence | 16.65 | 11.26 | 90 | 173454 | 16913 | 64308275 |
Tendonitis | 16.61 | 11.26 | 18 | 173526 | 20264 | 64304924 |
Urinary retention | 16.54 | 11.26 | 72 | 173472 | 49129 | 64276059 |
Hypophagia | 16.53 | 11.26 | 53 | 173491 | 39534 | 64285654 |
Haematotoxicity | 16.50 | 11.26 | 7 | 173537 | 12889 | 64312299 |
Ear discomfort | 16.45 | 11.26 | 50 | 173494 | 7230 | 64317958 |
Throat irritation | 16.43 | 11.26 | 147 | 173397 | 32564 | 64292624 |
Portopulmonary hypertension | 16.35 | 11.26 | 8 | 173536 | 141 | 64325047 |
Blindness transient | 16.32 | 11.26 | 35 | 173509 | 4087 | 64321101 |
Colitis ulcerative | 16.17 | 11.26 | 23 | 173521 | 23005 | 64302183 |
Skin irritation | 16.16 | 11.26 | 58 | 173486 | 9136 | 64316052 |
Ventricular assist device insertion | 16.15 | 11.26 | 6 | 173538 | 51 | 64325137 |
Visual brightness | 16.15 | 11.26 | 6 | 173538 | 51 | 64325137 |
Product contamination | 16.08 | 11.26 | 17 | 173527 | 1052 | 64324136 |
Hypoglossal nerve paralysis | 16.05 | 11.26 | 5 | 173539 | 23 | 64325165 |
Joint range of motion decreased | 16.03 | 11.26 | 17 | 173527 | 19326 | 64305862 |
Biopsy kidney | 16 | 11.26 | 8 | 173536 | 148 | 64325040 |
Lymphadenopathy | 15.89 | 11.26 | 68 | 173476 | 46618 | 64278570 |
Right atrial dilatation | 15.86 | 11.26 | 14 | 173530 | 692 | 64324496 |
Thunderclap headache | 15.86 | 11.26 | 9 | 173535 | 217 | 64324971 |
Cataract operation | 15.86 | 11.26 | 33 | 173511 | 3773 | 64321415 |
Product storage error | 15.84 | 11.26 | 8 | 173536 | 13310 | 64311878 |
Blood cholesterol increased | 15.80 | 11.26 | 75 | 173469 | 49991 | 64275197 |
Muscle spasticity | 15.75 | 11.26 | 13 | 173531 | 16656 | 64308532 |
Optic disc disorder | 15.75 | 11.26 | 7 | 173537 | 98 | 64325090 |
Colonoscopy | 15.73 | 11.26 | 21 | 173523 | 1664 | 64323524 |
Pulmonary thrombosis | 15.72 | 11.26 | 63 | 173481 | 10455 | 64314733 |
Glare | 15.69 | 11.26 | 7 | 173537 | 99 | 64325089 |
Fistula repair | 15.66 | 11.26 | 6 | 173538 | 56 | 64325132 |
Gastrointestinal surgery | 15.50 | 11.26 | 9 | 173535 | 227 | 64324961 |
Eating disorder symptom | 15.48 | 11.26 | 6 | 173538 | 58 | 64325130 |
Catheter site hypersensitivity | 15.44 | 11.26 | 7 | 173537 | 103 | 64325085 |
Ejaculation disorder | 15.44 | 11.26 | 12 | 173532 | 496 | 64324692 |
Chronic hepatic failure | 15.37 | 11.26 | 15 | 173529 | 844 | 64324344 |
Biopsy | 15.31 | 11.26 | 12 | 173532 | 502 | 64324686 |
Osteomyelitis | 15.31 | 11.26 | 32 | 173512 | 27555 | 64297633 |
Balance disorder | 15.30 | 11.26 | 148 | 173396 | 83778 | 64241410 |
Adenotonsillectomy | 15.30 | 11.26 | 6 | 173538 | 60 | 64325128 |
Oesophageal dilation procedure | 15.30 | 11.26 | 6 | 173538 | 60 | 64325128 |
Thoracic cavity drainage | 15.25 | 11.26 | 9 | 173535 | 234 | 64324954 |
Drug level decreased | 15.11 | 11.26 | 6 | 173538 | 11497 | 64313691 |
Respiratory tract infection viral | 15.11 | 11.26 | 26 | 173518 | 2577 | 64322611 |
Hallucination, auditory | 15.06 | 11.26 | 14 | 173530 | 16925 | 64308263 |
Cardiac failure chronic | 15.02 | 11.26 | 56 | 173488 | 8985 | 64316203 |
Exostosis | 14.97 | 11.26 | 6 | 173538 | 11432 | 64313756 |
Bronchopulmonary dysplasia | 14.96 | 11.26 | 8 | 173536 | 171 | 64325017 |
Sudden cardiac death | 14.88 | 11.26 | 36 | 173508 | 4551 | 64320637 |
Atrioventricular septal defect | 14.87 | 11.26 | 6 | 173538 | 65 | 64325123 |
Catheter site erosion | 14.87 | 11.26 | 6 | 173538 | 65 | 64325123 |
Metapneumovirus infection | 14.87 | 11.26 | 19 | 173525 | 1442 | 64323746 |
Protein-losing gastroenteropathy | 14.77 | 11.26 | 12 | 173532 | 529 | 64324659 |
Primary headache associated with sexual activity | 14.76 | 11.26 | 3 | 173541 | 0 | 64325188 |
Orchidopexy | 14.76 | 11.26 | 3 | 173541 | 0 | 64325188 |
Pharyngeal injury | 14.76 | 11.26 | 3 | 173541 | 0 | 64325188 |
Breast tumour excision | 14.76 | 11.26 | 3 | 173541 | 0 | 64325188 |
Infusion site nodule | 14.76 | 11.26 | 9 | 173535 | 249 | 64324939 |
Acute hepatic failure | 14.73 | 11.26 | 30 | 173514 | 26082 | 64299106 |
Immunodeficiency | 14.72 | 11.26 | 13 | 173531 | 16111 | 64309077 |
Injection site warmth | 14.69 | 11.26 | 9 | 173535 | 13453 | 64311735 |
Hydronephrosis | 14.66 | 11.26 | 10 | 173534 | 14115 | 64311073 |
Polyarthritis | 14.63 | 11.26 | 4 | 173540 | 9711 | 64315477 |
Viral upper respiratory tract infection | 14.59 | 11.26 | 52 | 173492 | 8163 | 64317025 |
Hypophosphataemia | 14.52 | 11.26 | 11 | 173533 | 14709 | 64310479 |
Generalised oedema | 14.49 | 11.26 | 101 | 173443 | 20752 | 64304436 |
Oesophagogastric fundoplasty | 14.43 | 11.26 | 7 | 173537 | 121 | 64325067 |
Aortic valve repair | 14.43 | 11.26 | 4 | 173540 | 11 | 64325177 |
Adrenal insufficiency | 14.32 | 11.26 | 24 | 173520 | 22463 | 64302725 |
Retinal artery occlusion | 14.30 | 11.26 | 27 | 173517 | 2876 | 64322312 |
Central nervous system lesion | 14.27 | 11.26 | 7 | 173537 | 11842 | 64313346 |
Dermatitis exfoliative | 14.27 | 11.26 | 5 | 173539 | 10347 | 64314841 |
Right ventricular systolic pressure decreased | 14.25 | 11.26 | 6 | 173538 | 73 | 64325115 |
COVID-19 pneumonia | 14.25 | 11.26 | 14 | 173530 | 16490 | 64308698 |
Sudden visual loss | 14.18 | 11.26 | 5 | 173539 | 36 | 64325152 |
Blood carbon monoxide increased | 14.17 | 11.26 | 4 | 173540 | 12 | 64325176 |
Clubbing | 14.17 | 11.26 | 12 | 173532 | 561 | 64324627 |
Fibrinous bronchitis | 14.06 | 11.26 | 5 | 173539 | 37 | 64325151 |
Extra dose administered | 13.99 | 11.26 | 45 | 173499 | 6705 | 64318483 |
Blood alkaline phosphatase increased | 13.99 | 11.26 | 221 | 173323 | 56058 | 64269130 |
Retinal vascular disorder | 13.99 | 11.26 | 9 | 173535 | 274 | 64324914 |
Administration site infection | 13.93 | 11.26 | 4 | 173540 | 13 | 64325175 |
Status epilepticus | 13.90 | 11.26 | 23 | 173521 | 21640 | 64303548 |
Therapeutic response shortened | 13.87 | 11.26 | 5 | 173539 | 10165 | 64315023 |
Localised infection | 13.87 | 11.26 | 133 | 173411 | 30028 | 64295160 |
Oesophagitis | 13.85 | 11.26 | 23 | 173521 | 21607 | 64303581 |
Melaena | 13.71 | 11.26 | 86 | 173458 | 53462 | 64271726 |
Catheter site bruise | 13.68 | 11.26 | 9 | 173535 | 285 | 64324903 |
Limb operation | 13.65 | 11.26 | 26 | 173518 | 2788 | 64322400 |
Drain placement | 13.65 | 11.26 | 7 | 173537 | 137 | 64325051 |
Pancreatitis | 13.63 | 11.26 | 99 | 173445 | 59508 | 64265680 |
Hypernatraemia | 13.51 | 11.26 | 8 | 173536 | 12181 | 64313007 |
Catheter site scar | 13.49 | 11.26 | 4 | 173540 | 15 | 64325173 |
Musculoskeletal disorder | 13.47 | 11.26 | 17 | 173527 | 17889 | 64307299 |
Hepatitis cholestatic | 13.44 | 11.26 | 8 | 173536 | 12147 | 64313041 |
Renal injury | 13.42 | 11.26 | 13 | 173531 | 15416 | 64309772 |
Vision blurred | 13.40 | 11.26 | 328 | 173216 | 89988 | 64235200 |
Hyperhidrosis | 13.36 | 11.26 | 246 | 173298 | 124674 | 64200514 |
Application site erythema | 13.33 | 11.26 | 35 | 173509 | 4654 | 64320534 |
Infection | 13.32 | 11.26 | 387 | 173157 | 184493 | 64140695 |
Maculopathy | 13.28 | 11.26 | 24 | 173520 | 2472 | 64322716 |
Liver injury | 13.26 | 11.26 | 39 | 173505 | 29893 | 64295295 |
Rash pustular | 13.24 | 11.26 | 5 | 173539 | 9880 | 64315308 |
Dermatitis bullous | 13.24 | 11.26 | 8 | 173536 | 12046 | 64313142 |
Blindness | 13.21 | 11.26 | 103 | 173441 | 21916 | 64303272 |
Intestinal perforation | 13.21 | 11.26 | 13 | 173531 | 15300 | 64309888 |
Enterocolitis | 13.16 | 11.26 | 8 | 173536 | 12010 | 64313178 |
Human metapneumovirus test positive | 13.12 | 11.26 | 7 | 173537 | 149 | 64325039 |
Exposure to fungus | 13.07 | 11.26 | 6 | 173538 | 91 | 64325097 |
Aphasia | 13.07 | 11.26 | 61 | 173483 | 40845 | 64284343 |
Vertigo | 13.02 | 11.26 | 99 | 173445 | 58912 | 64266276 |
Substance use | 13.02 | 11.26 | 12 | 173532 | 628 | 64324560 |
Infusion site discomfort | 13.00 | 11.26 | 13 | 173531 | 753 | 64324435 |
Spinal stenosis | 13.00 | 11.26 | 11 | 173533 | 13920 | 64311268 |
Middle ear effusion | 12.98 | 11.26 | 21 | 173523 | 1978 | 64323210 |
Gastric ulcer | 12.96 | 11.26 | 40 | 173504 | 30194 | 64294994 |
Cardiac arrest | 12.90 | 11.26 | 522 | 173022 | 153542 | 64171646 |
Catheter site cellulitis | 12.87 | 11.26 | 10 | 173534 | 413 | 64324775 |
Secretion discharge | 12.87 | 11.26 | 65 | 173479 | 11899 | 64313289 |
Collateral circulation | 12.84 | 11.26 | 5 | 173539 | 49 | 64325139 |
Endarterectomy | 12.81 | 11.26 | 9 | 173535 | 318 | 64324870 |
Subdural haematoma evacuation | 12.75 | 11.26 | 5 | 173539 | 50 | 64325138 |
Epstein-Barr virus infection | 12.75 | 11.26 | 9 | 173535 | 12479 | 64312709 |
Blood ethanol increased | 12.74 | 11.26 | 12 | 173532 | 646 | 64324542 |
Dry eye | 12.72 | 11.26 | 38 | 173506 | 28981 | 64296207 |
Conjunctivitis | 12.70 | 11.26 | 22 | 173522 | 20332 | 64304856 |
Biopsy colon | 12.69 | 11.26 | 3 | 173541 | 3 | 64325185 |
Cell-free and concentrated ascites reinfusion therapy | 12.69 | 11.26 | 3 | 173541 | 3 | 64325185 |
Fasciectomy | 12.69 | 11.26 | 3 | 173541 | 3 | 64325185 |
Male orgasmic disorder | 12.66 | 11.26 | 5 | 173539 | 51 | 64325137 |
Implantable defibrillator insertion | 12.65 | 11.26 | 13 | 173531 | 778 | 64324410 |
Nervous system disorder | 12.61 | 11.26 | 27 | 173517 | 23051 | 64302137 |
Low cardiac output syndrome | 12.60 | 11.26 | 13 | 173531 | 782 | 64324406 |
Skin necrosis | 12.55 | 11.26 | 12 | 173532 | 14317 | 64310871 |
Hysterectomy | 12.51 | 11.26 | 36 | 173508 | 5049 | 64320139 |
Drug titration error | 12.49 | 11.26 | 14 | 173530 | 926 | 64324262 |
Kidney transplant rejection | 12.43 | 11.26 | 5 | 173539 | 9506 | 64315682 |
Cardiac discomfort | 12.43 | 11.26 | 15 | 173529 | 1074 | 64324114 |
Gastric antral vascular ectasia | 12.42 | 11.26 | 13 | 173531 | 795 | 64324393 |
Metastases to lymph nodes | 12.38 | 11.26 | 4 | 173540 | 8713 | 64316475 |
Respiratory tract irritation | 12.36 | 11.26 | 11 | 173533 | 550 | 64324638 |
Thyroidectomy | 12.36 | 11.26 | 13 | 173531 | 800 | 64324388 |
Life support | 12.34 | 11.26 | 10 | 173534 | 439 | 64324749 |
Executive dysfunction | 12.31 | 11.26 | 8 | 173536 | 248 | 64324940 |
Drug withdrawal syndrome | 12.31 | 11.26 | 43 | 173501 | 31248 | 64293940 |
Ejection fraction decreased | 12.29 | 11.26 | 38 | 173506 | 28669 | 64296519 |
Annuloplasty | 12.23 | 11.26 | 3 | 173541 | 4 | 64325184 |
Hip fracture | 12.21 | 11.26 | 119 | 173425 | 26980 | 64298208 |
Bronchitis | 12.21 | 11.26 | 381 | 173163 | 108362 | 64216826 |
Abdominal pain upper | 12.21 | 11.26 | 582 | 172962 | 174448 | 64150740 |
Polypectomy | 12.17 | 11.26 | 14 | 173530 | 952 | 64324236 |
Oesophagogastroduodenoscopy | 12.11 | 11.26 | 7 | 173537 | 175 | 64325013 |
Carbon dioxide abnormal | 12.08 | 11.26 | 8 | 173536 | 256 | 64324932 |
Cardiac index decreased | 12 | 11.26 | 6 | 173538 | 111 | 64325077 |
Atrioventricular block first degree | 11.96 | 11.26 | 7 | 173537 | 10727 | 64314461 |
Tongue disorder | 11.95 | 11.26 | 9 | 173535 | 12071 | 64313117 |
Brain oedema | 11.92 | 11.26 | 26 | 173518 | 22049 | 64303139 |
Needle issue | 11.91 | 11.26 | 5 | 173539 | 9267 | 64315921 |
Stress cardiomyopathy | 11.88 | 11.26 | 5 | 173539 | 9252 | 64315936 |
Purulent discharge | 11.87 | 11.26 | 37 | 173507 | 5424 | 64319764 |
Vertebral artery stenosis | 11.86 | 11.26 | 7 | 173537 | 182 | 64325006 |
Platelet count increased | 11.86 | 11.26 | 20 | 173524 | 18676 | 64306512 |
Cholecystitis acute | 11.84 | 11.26 | 8 | 173536 | 11352 | 64313836 |
Echocardiogram | 11.83 | 11.26 | 4 | 173540 | 25 | 64325163 |
Bone density decreased | 11.80 | 11.26 | 6 | 173538 | 9946 | 64315242 |
Cardiopulmonary failure | 11.78 | 11.26 | 40 | 173504 | 6130 | 64319058 |
Guillain-Barre syndrome | 11.77 | 11.26 | 3 | 173541 | 7632 | 64317556 |
Macular detachment | 11.76 | 11.26 | 7 | 173537 | 185 | 64325003 |
Dyspepsia | 11.72 | 11.26 | 291 | 173253 | 80021 | 64245167 |
Ileus paralytic | 11.71 | 11.26 | 4 | 173540 | 8411 | 64316777 |
Sickle cell anaemia | 11.69 | 11.26 | 11 | 173533 | 591 | 64324597 |
Gastroenteritis viral | 11.68 | 11.26 | 92 | 173452 | 19637 | 64305551 |
Sinusitis | 11.66 | 11.26 | 301 | 173243 | 145627 | 64179561 |
Drug dependence | 11.66 | 11.26 | 48 | 173496 | 33264 | 64291924 |
Suture related complication | 11.63 | 11.26 | 8 | 173536 | 273 | 64324915 |
Cardiogenic shock | 11.62 | 11.26 | 136 | 173408 | 32291 | 64292897 |
Epstein-Barr virus antibody positive | 11.55 | 11.26 | 11 | 173533 | 600 | 64324588 |
Oesophageal variceal ligation | 11.54 | 11.26 | 6 | 173538 | 121 | 64325067 |
Upper limb fracture | 11.53 | 11.26 | 74 | 173470 | 14792 | 64310396 |
Emergency care examination | 11.52 | 11.26 | 5 | 173539 | 66 | 64325122 |
Tenderness | 11.51 | 11.26 | 22 | 173522 | 19580 | 64305608 |
Intestinal adhesion lysis | 11.48 | 11.26 | 3 | 173541 | 6 | 64325182 |
Sedative therapy | 11.48 | 11.26 | 3 | 173541 | 6 | 64325182 |
Implant site extravasation | 11.47 | 11.26 | 12 | 173532 | 734 | 64324454 |
Blood pressure diastolic decreased | 11.45 | 11.26 | 27 | 173517 | 22274 | 64302914 |
Spinal osteoarthritis | 11.45 | 11.26 | 13 | 173531 | 14328 | 64310860 |
Hyperbilirubinaemia | 11.43 | 11.26 | 25 | 173519 | 21180 | 64304008 |
Contusion | 11.39 | 11.26 | 227 | 173317 | 113738 | 64211450 |
Night sweats | 11.37 | 11.26 | 54 | 173490 | 35992 | 64289196 |
Lung operation | 11.37 | 11.26 | 7 | 173537 | 197 | 64324991 |
Injection site infection | 11.32 | 11.26 | 19 | 173525 | 1846 | 64323342 |
Hepatic steatosis | 11.28 | 11.26 | 44 | 173500 | 30963 | 64294225 |
None
Source | Code | Description |
---|---|---|
ATC | G04BE03 | GENITO URINARY SYSTEM AND SEX HORMONES UROLOGICALS UROLOGICALS Drugs used in erectile dysfunction |
FDA MoA | N0000020026 | Phosphodiesterase 5 Inhibitors |
FDA EPC | N0000175599 | Phosphodiesterase 5 Inhibitor |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D058986 | Phosphodiesterase 5 Inhibitors |
MeSH PA | D010726 | Phosphodiesterase Inhibitors |
MeSH PA | D064804 | Urological Agents |
MeSH PA | D014665 | Vasodilator Agents |
CHEBI has role | CHEBI:35620 | vasodilator agents |
CHEBI has role | CHEBI:71942 | PDE5 inhibitor |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Pulmonary arterial hypertension | indication | 11399002 | |
Impotence | indication | 397803000 | |
Induratio penis plastica | contraindication | 1335005 | DOID:8616 |
Priapism | contraindication | 6273006 | DOID:9286 |
Hearing loss | contraindication | 15188001 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Fibrosis of corpus cavernosum | contraindication | 32608004 | |
Dehydration | contraindication | 34095006 | |
Low blood pressure | contraindication | 45007003 | |
Chronic heart failure | contraindication | 48447003 | |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Aortic valve stenosis | contraindication | 60573004 | DOID:1712 |
Pulmonary veno-occlusive disease | contraindication | 89420002 | DOID:5453 |
Leukemia, disease | contraindication | 93143009 | DOID:1240 |
Multiple myeloma | contraindication | 109989006 | DOID:9538 |
Hb SS disease | contraindication | 127040003 | DOID:10923 |
Cerebrovascular accident | contraindication | 230690007 | |
Penis bent | contraindication | 249247007 | |
Esophageal dysmotility | contraindication | 266434009 | DOID:9192 |
Idiopathic hypertrophic subaortic stenosis | contraindication | 360465008 | |
Acute coronary syndrome | contraindication | 394659003 | |
Anterior ischemic optic neuropathy | contraindication | 404659001 | |
Hypertensive urgency | contraindication | 443482000 | |
Pigmentary Retinopathy | contraindication | ||
Severe Autonomic Insufficiency | contraindication | ||
Hereditary Degeneration of Retina | contraindication | ||
Life-Threatening Cardiac Arrhythmias | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.35 | acidic |
pKa2 | 7.72 | Basic |
pKa3 | 3.61 | Basic |
pKa4 | 2.92 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
cGMP-specific 3',5'-cyclic phosphodiesterase | Enzyme | INHIBITOR | IC50 | 9 | IUPHAR | CHEMBL | |||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 5.48 | CHEMBL | |||||
Adenosine receptor A1 | GPCR | Ki | 6.06 | DRUG MATRIX | |||||
Multidrug resistance-associated protein 5 | Transporter | Ki | 5.92 | CHEMBL | |||||
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha | Enzyme | WOMBAT-PK | |||||||
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | Enzyme | IC50 | 5.64 | CHEMBL | |||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | Enzyme | IC50 | 5.51 | CHEMBL | |||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Enzyme | IC50 | 4.70 | CHEMBL | |||||
cGMP-dependent 3',5'-cyclic phosphodiesterase | Enzyme | IC50 | 4.20 | CHEMBL | |||||
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | Enzyme | IC50 | 5.33 | CHEMBL | |||||
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' | Enzyme | IC50 | 7.41 | CHEMBL | |||||
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | Enzyme | IC50 | 5.47 | CHEMBL | |||||
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A | Enzyme | IC50 | 4 | CHEMBL | |||||
Phosphodiesterase 3 | Enzyme | IC50 | 5.15 | CHEMBL | |||||
Phosphodiesterase 4 | Enzyme | IC50 | 5.11 | CHEMBL | |||||
Phosphodiesterase 1 | Enzyme | IC50 | 6.57 | CHEMBL | |||||
Solute carrier organic anion transporter family member 1B3 | Transporter | INHIBITOR | IC50 | 6.10 | IUPHAR | ||||
Adenosine receptor A2a | GPCR | Ki | 6.70 | CHEMBL | |||||
Alpha-1B adrenergic receptor | GPCR | Ki | 6.09 | DRUG MATRIX | |||||
cGMP-specific 3',5'-cyclic phosphodiesterase | Enzyme | Ki | 8.74 | CHEMBL | |||||
Uncharacterized protein | Enzyme | IC50 | 5.04 | CHEMBL | |||||
cGMP-specific 3',5'-cyclic phosphodiesterase | Enzyme | IC50 | 8.22 | CHEMBL | |||||
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' | Enzyme | IC50 | 7.48 | CHEMBL | |||||
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha | Enzyme | IC50 | 6.85 | CHEMBL | |||||
Indoleamine 2,3-dioxygenase 2 | Enzyme | IC50 | 5.35 | CHEMBL | |||||
cGMP-specific 3',5'-cyclic phosphodiesterase | Enzyme | IC50 | 9 | CHEMBL | |||||
Phosphodiesterase 4 | Enzyme | IC50 | 5.34 | CHEMBL | |||||
Phosphodiesterase 1 | Enzyme | IC50 | 6.40 | CHEMBL | |||||
Phosphodiesterase 6 | Enzyme | IC50 | 7.70 | CHEMBL | |||||
Phosphodiesterase 1 | Enzyme | IC50 | 6.59 | CHEMBL | |||||
Phosphodiesterase 2A | Enzyme | IC50 | 4.37 | CHEMBL |
ID | Source |
---|---|
4024110 | VUID |
N0000022115 | NUI |
D02229 | KEGG_DRUG |
171599-83-0 | SECONDARY_CAS_RN |
4021093 | VANDF |
4024110 | VANDF |
C1318700 | UMLSCUI |
CHEBI:9139 | CHEBI |
VIA | PDB_CHEM_ID |
CHEMBL192 | ChEMBL_ID |
CHEMBL1737 | ChEMBL_ID |
D000068677 | MESH_DESCRIPTOR_UI |
DB00203 | DRUGBANK_ID |
4743 | IUPHAR_LIGAND_ID |
7374 | INN_ID |
3M7OB98Y7H | UNII |
135398744 | PUBCHEM_CID |
136411 | RXNORM |
147641 | MMSL |
194438 | MMSL |
26866 | MMSL |
29679 | MMSL |
5460 | MMSL |
69683 | MMSL |
d04299 | MMSL |
007448 | NDDF |
007449 | NDDF |
108482004 | SNOMEDCT_US |
109123009 | SNOMEDCT_US |
372572000 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Revatio | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0336 | POWDER, FOR SUSPENSION | 10 mg | ORAL | NDA | 28 sections |
Revatio | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0338 | INJECTION, SOLUTION | 0.80 mg | INTRAVENOUS | NDA | 28 sections |
Revatio | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-4190 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 28 sections |
Viagra | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-4200 | TABLET, FILM COATED | 25 mg | ORAL | NDA | 28 sections |
Viagra | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-4210 | TABLET, FILM COATED | 50 mg | ORAL | NDA | 28 sections |
Viagra | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-4220 | TABLET, FILM COATED | 100 mg | ORAL | NDA | 28 sections |
Sildenafil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5341 | TABLET, FILM COATED | 25 mg | ORAL | ANDA | 26 sections |
Sildenafil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5342 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 26 sections |
Sildenafil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5343 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 26 sections |
Sildenafil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5517 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 26 sections |
Sildenafil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1657 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 28 sections |
Sildenafil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1658 | TABLET, FILM COATED | 25 mg | ORAL | ANDA | 29 sections |
Sildenafil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1659 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 29 sections |
Sildenafil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1660 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 29 sections |
Sildenafil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-4050 | POWDER, FOR SUSPENSION | 10 mg | ORAL | ANDA | 26 sections |
SILDENAFIL CITRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6671 | TABLET | 20 mg | ORAL | ANDA | 26 sections |
SILDENAFIL CITRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-185 | TABLET | 20 mg | ORAL | ANDA | 27 sections |
SILDENAFIL CITRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-185 | TABLET | 20 mg | ORAL | ANDA | 27 sections |
SILDENAFIL CITRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-186 | TABLET, FILM COATED | 25 mg | ORAL | ANDA | 19 sections |
SILDENAFIL CITRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-186 | TABLET, FILM COATED | 25 mg | ORAL | ANDA | 19 sections |
SILDENAFIL CITRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-187 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 19 sections |
SILDENAFIL CITRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-187 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 19 sections |
SILDENAFIL CITRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-188 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 19 sections |
SILDENAFIL CITRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-188 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 19 sections |
Sildenafil | Human Prescription Drug Label | 1 | 17224-460 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 26 sections |
Sildenafil Citrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17856-8100 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 26 sections |
Viagra | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-157 | TABLET, FILM COATED | 50 mg | ORAL | NDA | 14 sections |
Viagra | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-158 | TABLET, FILM COATED | 100 mg | ORAL | NDA | 14 sections |
Sildenafil Citrate | Human Prescription Drug Label | 1 | 27241-067 | TABLET, FILM COATED | 25 mg | ORAL | ANDA | 26 sections |
Sildenafil Citrate | Human Prescription Drug Label | 1 | 27241-068 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 26 sections |