Stem definition | Drug id | CAS RN |
---|---|---|
inhibitors of phosphodiesterase PDE5 with vasodilator action | 2441 | 139755-83-2 |
Dose | Unit | Route |
---|---|---|
50 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 3.50 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 7.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 3.52 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 38 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 1.36 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 9 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.04 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 2.20 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
March 27, 1998 | FDA | PFIZER IRELAND |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Pulmonary arterial hypertension | 3001.59 | 13.04 | 1404 | 114011 | 24524 | 46546123 |
Dyspnoea | 2014.65 | 13.04 | 4112 | 111303 | 511436 | 46059211 |
Pulmonary hypertension | 1741.90 | 13.04 | 1093 | 114322 | 34900 | 46535747 |
Fluid retention | 1631.66 | 13.04 | 1199 | 114216 | 49847 | 46520800 |
Right ventricular failure | 1562.46 | 13.04 | 773 | 114642 | 15320 | 46555327 |
Pain in jaw | 1193.41 | 13.04 | 887 | 114528 | 37485 | 46533162 |
Death | 1105.34 | 13.04 | 2505 | 112910 | 333043 | 46237604 |
Fluid overload | 792.93 | 13.04 | 605 | 114810 | 26580 | 46544067 |
Dyspnoea exertional | 776.76 | 13.04 | 779 | 114636 | 49510 | 46521137 |
Drug ineffective | 673.13 | 13.04 | 426 | 114989 | 677412 | 45893235 |
Catheter site erythema | 620.97 | 13.04 | 266 | 115149 | 3717 | 46566930 |
Headache | 614.34 | 13.04 | 2568 | 112847 | 475784 | 46094863 |
Nasal congestion | 507.23 | 13.04 | 610 | 114805 | 47503 | 46523144 |
Oxygen saturation decreased | 491.76 | 13.04 | 723 | 114692 | 68441 | 46502206 |
Lung transplant | 490.29 | 13.04 | 205 | 115210 | 2687 | 46567960 |
Oedema | 489.74 | 13.04 | 710 | 114705 | 66361 | 46504286 |
Transfusion | 486.82 | 13.04 | 339 | 115076 | 12892 | 46557755 |
Hospitalisation | 452.61 | 13.04 | 664 | 114751 | 62721 | 46507926 |
Device related infection | 452.24 | 13.04 | 392 | 115023 | 20649 | 46549998 |
Flushing | 445.74 | 13.04 | 666 | 114749 | 63948 | 46506699 |
Catheter site pruritus | 431.10 | 13.04 | 168 | 115247 | 1811 | 46568836 |
Catheter management | 423.66 | 13.04 | 183 | 115232 | 2612 | 46568035 |
Catheter site pain | 414.79 | 13.04 | 198 | 115217 | 3608 | 46567039 |
Rheumatoid arthritis | 386.27 | 13.04 | 65 | 115350 | 240150 | 46330497 |
Infusion site pain | 381.29 | 13.04 | 263 | 115152 | 9844 | 46560803 |
Toxicity to various agents | 347.81 | 13.04 | 54 | 115361 | 211712 | 46358935 |
Hypoxia | 339.95 | 13.04 | 522 | 114893 | 51316 | 46519331 |
Pulmonary arterial pressure increased | 320.01 | 13.04 | 159 | 115256 | 3173 | 46567474 |
Chest pain | 318.63 | 13.04 | 1059 | 114356 | 175265 | 46395382 |
Catheter site discharge | 318.30 | 13.04 | 135 | 115280 | 1837 | 46568810 |
Completed suicide | 305.06 | 13.04 | 13 | 115402 | 145907 | 46424740 |
Catheterisation cardiac | 299.20 | 13.04 | 162 | 115253 | 3885 | 46566762 |
Drug hypersensitivity | 290.10 | 13.04 | 120 | 115295 | 243705 | 46326942 |
Oedema peripheral | 278.53 | 13.04 | 948 | 114467 | 158758 | 46411889 |
Catheter site infection | 277.52 | 13.04 | 163 | 115252 | 4590 | 46566057 |
Cardiac failure | 274.72 | 13.04 | 609 | 114806 | 79339 | 46491308 |
Neutropenia | 271.38 | 13.04 | 22 | 115393 | 143182 | 46427465 |
Syncope | 266.73 | 13.04 | 711 | 114704 | 104092 | 46466555 |
Cough | 250.35 | 13.04 | 1179 | 114236 | 229070 | 46341577 |
Oxygen consumption increased | 247.02 | 13.04 | 138 | 115277 | 3525 | 46567122 |
Pulmonary oedema | 242.08 | 13.04 | 445 | 114970 | 50660 | 46519987 |
Condition aggravated | 237.99 | 13.04 | 1215 | 114200 | 243837 | 46326810 |
Central venous catheterisation | 228.52 | 13.04 | 108 | 115307 | 1922 | 46568725 |
Catheter site swelling | 221.77 | 13.04 | 93 | 115322 | 1228 | 46569419 |
Scleroderma | 219.60 | 13.04 | 139 | 115276 | 4490 | 46566157 |
Infusion site erythema | 218.11 | 13.04 | 168 | 115247 | 7474 | 46563173 |
Pneumonia | 216.58 | 13.04 | 1630 | 113785 | 374690 | 46195957 |
Infusion related reaction | 211.53 | 13.04 | 9 | 115406 | 101199 | 46469448 |
Drug interaction | 205.29 | 13.04 | 124 | 115291 | 202970 | 46367677 |
Device leakage | 203.27 | 13.04 | 140 | 115275 | 5225 | 46565422 |
Alopecia | 202.83 | 13.04 | 74 | 115341 | 162340 | 46408307 |
Catheter placement | 199.46 | 13.04 | 97 | 115318 | 1844 | 46568803 |
Device alarm issue | 191.17 | 13.04 | 85 | 115330 | 1305 | 46569342 |
Catheter site haemorrhage | 190.73 | 13.04 | 105 | 115310 | 2604 | 46568043 |
Palpitations | 189.76 | 13.04 | 592 | 114823 | 94667 | 46475980 |
Respiratory failure | 186.81 | 13.04 | 587 | 114828 | 94229 | 46476418 |
Treatment failure | 185.89 | 13.04 | 11 | 115404 | 93076 | 46477571 |
Febrile neutropenia | 183.57 | 13.04 | 13 | 115402 | 94614 | 46476033 |
Disease progression | 177.81 | 13.04 | 563 | 114852 | 90737 | 46479910 |
Rash | 177.73 | 13.04 | 386 | 115029 | 356126 | 46214521 |
Unevaluable event | 173.69 | 13.04 | 365 | 115050 | 45810 | 46524837 |
Infusion site infection | 171.57 | 13.04 | 80 | 115335 | 1379 | 46569268 |
Psoriasis | 171.18 | 13.04 | 5 | 115410 | 78599 | 46492048 |
Cardiac failure congestive | 166.22 | 13.04 | 552 | 114863 | 91198 | 46479449 |
Hypotension | 163.77 | 13.04 | 1059 | 114356 | 231530 | 46339117 |
Transplant evaluation | 161.59 | 13.04 | 70 | 115345 | 1006 | 46569641 |
Contraindicated product administered | 149.41 | 13.04 | 13 | 115402 | 79934 | 46490713 |
Concomitant disease aggravated | 141.99 | 13.04 | 133 | 115282 | 7749 | 46562898 |
Dizziness | 141.38 | 13.04 | 1372 | 114043 | 339042 | 46231605 |
Cardiac operation | 138.96 | 13.04 | 85 | 115330 | 2581 | 46568066 |
Therapy change | 136.80 | 13.04 | 108 | 115307 | 4982 | 46565665 |
Catheter site rash | 136.42 | 13.04 | 56 | 115359 | 698 | 46569949 |
Catheter site irritation | 134.41 | 13.04 | 49 | 115366 | 432 | 46570215 |
Diarrhoea | 129.85 | 13.04 | 2020 | 113395 | 557582 | 46013065 |
Acute respiratory failure | 129.53 | 13.04 | 247 | 115168 | 28891 | 46541756 |
Drug abuse | 128.09 | 13.04 | 7 | 115408 | 63401 | 46507246 |
Cardiac disorder | 127.43 | 13.04 | 313 | 115102 | 43545 | 46527102 |
Injection site pain | 126.81 | 13.04 | 53 | 115362 | 107099 | 46463548 |
Malignant neoplasm progression | 125.68 | 13.04 | 9 | 115406 | 64917 | 46505730 |
White blood cell count decreased | 121.25 | 13.04 | 63 | 115352 | 112168 | 46458479 |
Joint swelling | 120.25 | 13.04 | 140 | 115275 | 165933 | 46404714 |
Malaise | 118.88 | 13.04 | 1296 | 114119 | 329936 | 46240711 |
Dialysis | 117.68 | 13.04 | 135 | 115280 | 9981 | 46560666 |
Therapeutic product effect decreased | 116.80 | 13.04 | 30 | 115385 | 82571 | 46488076 |
Musculoskeletal stiffness | 116.72 | 13.04 | 48 | 115367 | 97945 | 46472702 |
Product dose omission issue | 116.44 | 13.04 | 764 | 114651 | 167756 | 46402891 |
Urticaria | 116.21 | 13.04 | 74 | 115341 | 117818 | 46452829 |
Depression | 116.21 | 13.04 | 150 | 115265 | 169954 | 46400693 |
Pulmonary veno-occlusive disease | 116.11 | 13.04 | 53 | 115362 | 868 | 46569779 |
Device occlusion | 114.23 | 13.04 | 104 | 115311 | 5841 | 46564806 |
Dermatitis contact | 112.87 | 13.04 | 119 | 115296 | 8004 | 46562643 |
Hypertension | 110.22 | 13.04 | 198 | 115217 | 196158 | 46374489 |
Exercise tolerance decreased | 110.05 | 13.04 | 91 | 115324 | 4486 | 46566161 |
Overdose | 106.14 | 13.04 | 60 | 115355 | 101919 | 46468728 |
Epistaxis | 105.14 | 13.04 | 374 | 115041 | 63931 | 46506716 |
Dyspnoea at rest | 104.84 | 13.04 | 80 | 115335 | 3508 | 46567139 |
Ascites | 104.07 | 13.04 | 259 | 115156 | 36325 | 46534322 |
Pulmonary hypertensive crisis | 103.23 | 13.04 | 32 | 115383 | 160 | 46570487 |
Paracentesis | 102.47 | 13.04 | 49 | 115366 | 896 | 46569751 |
Infusion site swelling | 102.34 | 13.04 | 96 | 115319 | 5603 | 46565044 |
Vascular device infection | 101.85 | 13.04 | 78 | 115337 | 3439 | 46567208 |
Anaphylactic reaction | 100.98 | 13.04 | 8 | 115407 | 53104 | 46517543 |
Infusion site discharge | 100.53 | 13.04 | 42 | 115373 | 549 | 46570098 |
Stomatitis | 98.11 | 13.04 | 24 | 115391 | 68273 | 46502374 |
Device infusion issue | 95.45 | 13.04 | 49 | 115366 | 1050 | 46569597 |
Catheter site inflammation | 94.85 | 13.04 | 42 | 115373 | 638 | 46570009 |
Pericardial effusion | 93.80 | 13.04 | 200 | 115215 | 25343 | 46545304 |
Therapy non-responder | 91.51 | 13.04 | 266 | 115149 | 40886 | 46529761 |
Chest discomfort | 91.12 | 13.04 | 453 | 114962 | 89816 | 46480831 |
Suicidal ideation | 91.01 | 13.04 | 15 | 115400 | 56367 | 46514280 |
Injection site erythema | 91.01 | 13.04 | 35 | 115380 | 74392 | 46496255 |
Intentional overdose | 89.14 | 13.04 | 25 | 115390 | 64919 | 46505728 |
Electrocardiogram QT prolonged | 89.04 | 13.04 | 11 | 115404 | 51314 | 46519333 |
Therapeutic product effect incomplete | 88.75 | 13.04 | 41 | 115374 | 78112 | 46492535 |
Leukopenia | 87.19 | 13.04 | 30 | 115385 | 68313 | 46502334 |
Multiple sclerosis relapse | 87.15 | 13.04 | 4 | 115411 | 42121 | 46528526 |
Peripheral swelling | 86.72 | 13.04 | 678 | 114737 | 157393 | 46413254 |
Pruritus | 85.90 | 13.04 | 309 | 115106 | 242043 | 46328604 |
Right ventricular dysfunction | 85.84 | 13.04 | 51 | 115364 | 1467 | 46569180 |
Abdominal distension | 85.63 | 13.04 | 384 | 115031 | 72967 | 46497680 |
Catheter site related reaction | 85.48 | 13.04 | 41 | 115374 | 755 | 46569892 |
N-terminal prohormone brain natriuretic peptide increased | 85.23 | 13.04 | 53 | 115362 | 1658 | 46568989 |
Complication associated with device | 84.08 | 13.04 | 143 | 115272 | 15298 | 46555349 |
Cardiac pacemaker insertion | 83.68 | 13.04 | 71 | 115344 | 3628 | 46567019 |
Injection site reaction | 83.64 | 13.04 | 10 | 115405 | 47839 | 46522808 |
Emergency care | 83.29 | 13.04 | 41 | 115374 | 801 | 46569846 |
Blood pressure increased | 83.11 | 13.04 | 115 | 115300 | 126551 | 46444096 |
Mucosal inflammation | 82.98 | 13.04 | 3 | 115412 | 38973 | 46531674 |
Device dislocation | 82.71 | 13.04 | 173 | 115242 | 21629 | 46549018 |
Presyncope | 82.44 | 13.04 | 185 | 115230 | 24269 | 46546378 |
Walking distance test abnormal | 82.07 | 13.04 | 35 | 115380 | 483 | 46570164 |
Haemoptysis | 81.53 | 13.04 | 192 | 115223 | 25997 | 46544650 |
Neutrophil count decreased | 81.29 | 13.04 | 7 | 115408 | 43419 | 46527228 |
Brain natriuretic peptide increased | 80.96 | 13.04 | 77 | 115338 | 4573 | 46566074 |
Suicide attempt | 79.71 | 13.04 | 19 | 115396 | 55017 | 46515630 |
Acute kidney injury | 79.47 | 13.04 | 307 | 115108 | 235548 | 46335099 |
Arthropathy | 78.33 | 13.04 | 57 | 115358 | 84643 | 46486004 |
Maternal exposure during pregnancy | 77.97 | 13.04 | 83 | 115332 | 102466 | 46468181 |
Oxygen therapy | 76.40 | 13.04 | 51 | 115364 | 1806 | 46568841 |
Hypersensitivity | 76.14 | 13.04 | 161 | 115254 | 150160 | 46420487 |
Glossodynia | 75.79 | 13.04 | 10 | 115405 | 44363 | 46526284 |
Neuropathy peripheral | 75.53 | 13.04 | 68 | 115347 | 90825 | 46479822 |
Productive cough | 75.35 | 13.04 | 286 | 115129 | 50429 | 46520218 |
Confusional state | 73.89 | 13.04 | 180 | 115235 | 159712 | 46410935 |
Off label use | 73.51 | 13.04 | 594 | 114821 | 379247 | 46191400 |
Cardiac ablation | 73.03 | 13.04 | 43 | 115372 | 1216 | 46569431 |
Coma | 72.06 | 13.04 | 27 | 115388 | 58322 | 46512325 |
Injection site bruising | 71.76 | 13.04 | 4 | 115411 | 35632 | 46535015 |
Infusion site haemorrhage | 71.40 | 13.04 | 52 | 115363 | 2122 | 46568525 |
Arthralgia | 71.09 | 13.04 | 569 | 114846 | 364034 | 46206613 |
Deep vein thrombosis | 70.80 | 13.04 | 56 | 115359 | 79717 | 46490930 |
Drug intolerance | 70.77 | 13.04 | 162 | 115253 | 146887 | 46423760 |
Pancytopenia | 70.24 | 13.04 | 64 | 115351 | 84994 | 46485653 |
Osteoarthritis | 69.71 | 13.04 | 33 | 115382 | 61992 | 46508655 |
Catheter site vesicles | 69.06 | 13.04 | 26 | 115389 | 253 | 46570394 |
Heart rate increased | 68.96 | 13.04 | 366 | 115049 | 74425 | 46496222 |
Cor pulmonale | 67.30 | 13.04 | 48 | 115367 | 1895 | 46568752 |
Wrong technique in product usage process | 65.85 | 13.04 | 26 | 115389 | 54396 | 46516251 |
Plasma cell myeloma | 65.12 | 13.04 | 15 | 115400 | 44463 | 46526184 |
Systemic scleroderma | 64.94 | 13.04 | 35 | 115380 | 831 | 46569816 |
Atrial flutter | 63.99 | 13.04 | 95 | 115320 | 9053 | 46561594 |
Blood cholesterol increased | 63.79 | 13.04 | 11 | 115404 | 40002 | 46530645 |
Thrombocytopenia | 62.90 | 13.04 | 137 | 115278 | 126444 | 46444203 |
Paraesthesia | 62.68 | 13.04 | 122 | 115293 | 117315 | 46453332 |
Hyponatraemia | 62.53 | 13.04 | 96 | 115319 | 101236 | 46469411 |
Infusion site pruritus | 62.46 | 13.04 | 56 | 115359 | 3082 | 46567565 |
Hepatic enzyme increased | 62.38 | 13.04 | 66 | 115349 | 81721 | 46488926 |
Angioedema | 62.32 | 13.04 | 11 | 115404 | 39331 | 46531316 |
Balloon atrial septostomy | 61.50 | 13.04 | 18 | 115397 | 71 | 46570576 |
Myalgia | 61.00 | 13.04 | 516 | 114899 | 122572 | 46448075 |
Heart transplant | 60.69 | 13.04 | 27 | 115388 | 415 | 46570232 |
Influenza | 60.51 | 13.04 | 403 | 115012 | 88867 | 46481780 |
Infusion site irritation | 60.13 | 13.04 | 28 | 115387 | 481 | 46570166 |
Mechanical ventilation | 59.68 | 13.04 | 38 | 115377 | 1240 | 46569407 |
Hypoglycaemia | 59.43 | 13.04 | 30 | 115385 | 54319 | 46516328 |
Cyanosis | 58.57 | 13.04 | 125 | 115290 | 15846 | 46554801 |
Bone marrow failure | 57.73 | 13.04 | 4 | 115411 | 29665 | 46540982 |
Lung disorder | 57.68 | 13.04 | 236 | 115179 | 43068 | 46527579 |
Abdominal cavity drainage | 57.60 | 13.04 | 25 | 115390 | 361 | 46570286 |
Mobility decreased | 57.03 | 13.04 | 40 | 115375 | 60554 | 46510093 |
Heart and lung transplant | 56.95 | 13.04 | 18 | 115397 | 97 | 46570550 |
Injury | 56.71 | 13.04 | 19 | 115396 | 44008 | 46526639 |
Hallucination | 55.48 | 13.04 | 27 | 115388 | 49924 | 46520723 |
Right ventricular dilatation | 55.08 | 13.04 | 32 | 115383 | 882 | 46569765 |
Injection site swelling | 54.45 | 13.04 | 16 | 115399 | 40311 | 46530336 |
Disease complication | 54.40 | 13.04 | 51 | 115364 | 2974 | 46567673 |
Infusion site cellulitis | 54.06 | 13.04 | 19 | 115396 | 149 | 46570498 |
Hypoaesthesia | 53.96 | 13.04 | 135 | 115280 | 118734 | 46451913 |
Tracheostomy | 53.65 | 13.04 | 27 | 115388 | 554 | 46570093 |
Chronic respiratory failure | 53.42 | 13.04 | 40 | 115375 | 1704 | 46568943 |
Device related sepsis | 52.66 | 13.04 | 52 | 115363 | 3235 | 46567412 |
Impaired healing | 52.59 | 13.04 | 13 | 115402 | 36730 | 46533917 |
Ventilation perfusion mismatch | 52.29 | 13.04 | 20 | 115395 | 204 | 46570443 |
Drug reaction with eosinophilia and systemic symptoms | 52.07 | 13.04 | 6 | 115409 | 29542 | 46541105 |
Right ventricular systolic pressure increased | 51.91 | 13.04 | 26 | 115389 | 528 | 46570119 |
Atrial septal defect repair | 51.19 | 13.04 | 20 | 115395 | 217 | 46570430 |
Oxygen saturation abnormal | 51.15 | 13.04 | 47 | 115368 | 2671 | 46567976 |
Depressed level of consciousness | 50.91 | 13.04 | 27 | 115388 | 47542 | 46523105 |
Blood pressure decreased | 50.83 | 13.04 | 277 | 115138 | 56882 | 46513765 |
Cardioversion | 50.70 | 13.04 | 33 | 115382 | 1119 | 46569528 |
Terminal state | 50.45 | 13.04 | 43 | 115372 | 2211 | 46568436 |
Product quality issue | 50.27 | 13.04 | 13 | 115402 | 35635 | 46535012 |
Catheter removal | 50.18 | 13.04 | 22 | 115393 | 326 | 46570321 |
Emotional distress | 49.93 | 13.04 | 8 | 115407 | 30699 | 46539948 |
Nasopharyngitis | 49.81 | 13.04 | 591 | 114824 | 153407 | 46417240 |
Asthma | 49.79 | 13.04 | 94 | 115321 | 91448 | 46479199 |
Seizure | 49.68 | 13.04 | 148 | 115267 | 122906 | 46447741 |
Abortion spontaneous | 49.38 | 13.04 | 23 | 115392 | 43623 | 46527024 |
Catheter site warmth | 49.23 | 13.04 | 19 | 115396 | 199 | 46570448 |
Gout | 48.90 | 13.04 | 95 | 115320 | 11261 | 46559386 |
Injection site pruritus | 48.06 | 13.04 | 19 | 115396 | 39724 | 46530923 |
Packed red blood cell transfusion | 47.87 | 13.04 | 41 | 115374 | 2122 | 46568525 |
Thrombosis in device | 47.48 | 13.04 | 47 | 115368 | 2932 | 46567715 |
Infusion site warmth | 46.06 | 13.04 | 32 | 115383 | 1211 | 46569436 |
Exposure during pregnancy | 45.99 | 13.04 | 127 | 115288 | 108085 | 46462562 |
Blood creatine phosphokinase increased | 45.58 | 13.04 | 7 | 115408 | 27717 | 46542930 |
Therapeutic response decreased | 45.42 | 13.04 | 25 | 115390 | 43120 | 46527527 |
Finger amputation | 44.34 | 13.04 | 23 | 115392 | 504 | 46570143 |
Device breakage | 44.10 | 13.04 | 83 | 115332 | 9609 | 46561038 |
Concomitant disease progression | 43.86 | 13.04 | 39 | 115376 | 2123 | 46568524 |
Inappropriate schedule of product administration | 43.65 | 13.04 | 58 | 115357 | 64955 | 46505692 |
Pain in extremity | 43.62 | 13.04 | 889 | 114526 | 257791 | 46312856 |
Pulmonary arterial pressure abnormal | 43.60 | 13.04 | 22 | 115393 | 454 | 46570193 |
Congestive hepatopathy | 43.36 | 13.04 | 41 | 115374 | 2417 | 46568230 |
Hepatocellular injury | 43.12 | 13.04 | 10 | 115405 | 29512 | 46541135 |
Delirium | 43.08 | 13.04 | 19 | 115396 | 37209 | 46533438 |
Infusion site induration | 42.90 | 13.04 | 26 | 115389 | 776 | 46569871 |
Lung assist device therapy | 42.61 | 13.04 | 13 | 115402 | 61 | 46570586 |
Aspiration pleural cavity | 42.34 | 13.04 | 26 | 115389 | 795 | 46569852 |
Blood culture positive | 42.33 | 13.04 | 54 | 115361 | 4458 | 46566189 |
Injection site discharge | 42.31 | 13.04 | 20 | 115395 | 356 | 46570291 |
Transplant | 42.26 | 13.04 | 24 | 115391 | 633 | 46570014 |
Product use in unapproved indication | 42.16 | 13.04 | 101 | 115314 | 90172 | 46480475 |
Device physical property issue | 41.66 | 13.04 | 32 | 115383 | 1417 | 46569230 |
Multiple sclerosis | 41.36 | 13.04 | 6 | 115409 | 24785 | 46545862 |
Dependence on oxygen therapy | 40.61 | 13.04 | 19 | 115396 | 330 | 46570317 |
Stent placement | 40.59 | 13.04 | 47 | 115368 | 3509 | 46567138 |
Drug withdrawal syndrome | 40.55 | 13.04 | 9 | 115406 | 27375 | 46543272 |
Device malfunction | 40.48 | 13.04 | 97 | 115318 | 13277 | 46557370 |
Medical device change | 40.30 | 13.04 | 19 | 115396 | 336 | 46570311 |
Infusion site abscess | 40.05 | 13.04 | 16 | 115399 | 185 | 46570462 |
Generalised tonic-clonic seizure | 39.99 | 13.04 | 9 | 115406 | 27113 | 46543534 |
Internal haemorrhage | 39.73 | 13.04 | 52 | 115363 | 4403 | 46566244 |
Pulmonary pain | 39.62 | 13.04 | 33 | 115382 | 1643 | 46569004 |
Aggression | 39.14 | 13.04 | 5 | 115410 | 22739 | 46547908 |
Right ventricular hypertrophy | 39.01 | 13.04 | 23 | 115392 | 652 | 46569995 |
Arthritis | 38.95 | 13.04 | 83 | 115332 | 77233 | 46493414 |
Device connection issue | 38.95 | 13.04 | 23 | 115392 | 654 | 46569993 |
Lymphocyte count decreased | 38.73 | 13.04 | 8 | 115407 | 25581 | 46545066 |
Fibromyalgia | 38.57 | 13.04 | 21 | 115394 | 36442 | 46534205 |
Foetal exposure during pregnancy | 38.34 | 13.04 | 14 | 115401 | 30733 | 46539914 |
Lactic acidosis | 38.16 | 13.04 | 18 | 115397 | 33891 | 46536756 |
Bone disorder | 38.12 | 13.04 | 3 | 115412 | 20030 | 46550617 |
Rehabilitation therapy | 37.99 | 13.04 | 28 | 115387 | 1164 | 46569483 |
C-reactive protein increased | 37.60 | 13.04 | 54 | 115361 | 58536 | 46512111 |
Right ventricular enlargement | 37.60 | 13.04 | 17 | 115398 | 272 | 46570375 |
Catheterisation cardiac abnormal | 37.44 | 13.04 | 16 | 115399 | 222 | 46570425 |
Sedation | 37.18 | 13.04 | 6 | 115409 | 22904 | 46547743 |
Biopsy liver | 37.02 | 13.04 | 19 | 115396 | 407 | 46570240 |
Swollen tongue | 36.98 | 13.04 | 13 | 115402 | 29219 | 46541428 |
Agitation | 36.63 | 13.04 | 50 | 115365 | 55365 | 46515282 |
Chronic obstructive pulmonary disease | 36.55 | 13.04 | 256 | 115159 | 57377 | 46513270 |
Cognitive disorder | 36.52 | 13.04 | 23 | 115392 | 36860 | 46533787 |
Rhinovirus infection | 36.48 | 13.04 | 45 | 115370 | 3591 | 46567056 |
Sinus congestion | 36.42 | 13.04 | 92 | 115323 | 13017 | 46557630 |
Catheter site nodule | 36.16 | 13.04 | 11 | 115404 | 51 | 46570596 |
Catheter site discolouration | 36.13 | 13.04 | 13 | 115402 | 110 | 46570537 |
Pulmonary embolism | 36.08 | 13.04 | 142 | 115273 | 108443 | 46462204 |
Stevens-Johnson syndrome | 35.85 | 13.04 | 7 | 115408 | 23290 | 46547357 |
Osteoporosis | 35.40 | 13.04 | 29 | 115386 | 40579 | 46530068 |
Drug dependence | 35.17 | 13.04 | 4 | 115411 | 19897 | 46550750 |
Pericarditis | 35.16 | 13.04 | 8 | 115407 | 23919 | 46546728 |
Right-to-left cardiac shunt | 35.03 | 13.04 | 14 | 115401 | 162 | 46570485 |
Sopor | 35.00 | 13.04 | 4 | 115411 | 19824 | 46550823 |
Liver transplant | 34.63 | 13.04 | 36 | 115379 | 2381 | 46568266 |
Hyperglycaemia | 34.55 | 13.04 | 22 | 115393 | 35049 | 46535598 |
Disease recurrence | 34.50 | 13.04 | 3 | 115412 | 18468 | 46552179 |
Drug-induced liver injury | 34.37 | 13.04 | 10 | 115405 | 25358 | 46545289 |
Somnolence | 34.35 | 13.04 | 236 | 115179 | 156285 | 46414362 |
Cardiac failure acute | 34.08 | 13.04 | 67 | 115348 | 8011 | 46562636 |
Oral herpes | 34.01 | 13.04 | 4 | 115411 | 19386 | 46551261 |
Catheter site scab | 33.86 | 13.04 | 14 | 115401 | 178 | 46570469 |
Pleural effusion | 33.58 | 13.04 | 333 | 115082 | 82619 | 46488028 |
Respiratory distress | 33.47 | 13.04 | 162 | 115253 | 31754 | 46538893 |
Osteonecrosis | 33.35 | 13.04 | 11 | 115404 | 25733 | 46544914 |
Product use issue | 33.16 | 13.04 | 369 | 115046 | 94275 | 46476372 |
Dyskinesia | 33.10 | 13.04 | 15 | 115400 | 28910 | 46541737 |
Intentional product misuse | 32.71 | 13.04 | 41 | 115374 | 47087 | 46523560 |
Central venous catheter removal | 32.67 | 13.04 | 16 | 115399 | 309 | 46570338 |
Metabolic acidosis | 32.21 | 13.04 | 29 | 115386 | 38751 | 46531896 |
Pulmonary artery dilatation | 32.14 | 13.04 | 14 | 115401 | 204 | 46570443 |
Hyperlipidaemia | 32.08 | 13.04 | 4 | 115411 | 18535 | 46552112 |
Left-to-right cardiac shunt | 32.04 | 13.04 | 12 | 115403 | 115 | 46570532 |
Infusion site oedema | 31.93 | 13.04 | 18 | 115397 | 468 | 46570179 |
Dysphagia | 31.90 | 13.04 | 92 | 115323 | 77220 | 46493427 |
Basal cell carcinoma | 31.86 | 13.04 | 6 | 115409 | 20481 | 46550166 |
Hepatic steatosis | 31.62 | 13.04 | 10 | 115405 | 24032 | 46546615 |
Drug eruption | 31.60 | 13.04 | 7 | 115408 | 21322 | 46549325 |
Dizziness postural | 31.59 | 13.04 | 57 | 115358 | 6389 | 46564258 |
Hospice care | 31.46 | 13.04 | 51 | 115364 | 5244 | 46565403 |
Dysentery | 31.45 | 13.04 | 21 | 115394 | 744 | 46569903 |
Inflammation | 31.26 | 13.04 | 45 | 115370 | 48736 | 46521911 |
Feeling abnormal | 31.25 | 13.04 | 458 | 114957 | 124602 | 46446045 |
Acute right ventricular failure | 31.04 | 13.04 | 13 | 115402 | 171 | 46570476 |
Pulmonary artery aneurysm | 30.65 | 13.04 | 9 | 115406 | 36 | 46570611 |
Pulmonary vascular resistance abnormality | 30.65 | 13.04 | 9 | 115406 | 36 | 46570611 |
Hypocalcaemia | 30.47 | 13.04 | 14 | 115401 | 26771 | 46543876 |
Bursitis | 30.45 | 13.04 | 6 | 115409 | 19836 | 46550811 |
Pulmonary congestion | 30.36 | 13.04 | 93 | 115322 | 14706 | 46555941 |
Hyperkalaemia | 30.36 | 13.04 | 49 | 115366 | 50660 | 46519987 |
Skin lesion | 30.33 | 13.04 | 14 | 115401 | 26699 | 46543948 |
Peritonitis | 30.29 | 13.04 | 7 | 115408 | 20707 | 46549940 |
Blood culture negative | 29.57 | 13.04 | 12 | 115403 | 145 | 46570502 |
Drug resistance | 29.45 | 13.04 | 4 | 115411 | 17364 | 46553283 |
Vascular resistance pulmonary decreased | 29.43 | 13.04 | 10 | 115405 | 70 | 46570577 |
Aphasia | 29.42 | 13.04 | 17 | 115398 | 28550 | 46542097 |
Paranasal sinus hypersecretion | 29.33 | 13.04 | 38 | 115377 | 3186 | 46567461 |
Hypokalaemia | 29.31 | 13.04 | 115 | 115300 | 87909 | 46482738 |
Epilepsy | 29.28 | 13.04 | 11 | 115404 | 23727 | 46546920 |
Red blood cell sedimentation rate increased | 29.26 | 13.04 | 10 | 115405 | 22879 | 46547768 |
Renal disorder | 29.11 | 13.04 | 137 | 115278 | 26549 | 46544098 |
Abnormal behaviour | 29.08 | 13.04 | 8 | 115407 | 21050 | 46549597 |
Dysarthria | 28.87 | 13.04 | 30 | 115385 | 37468 | 46533179 |
Respiration abnormal | 28.86 | 13.04 | 45 | 115370 | 4476 | 46566171 |
Product supply issue | 28.83 | 13.04 | 21 | 115394 | 857 | 46569790 |
Orthopnoea | 28.82 | 13.04 | 52 | 115363 | 5828 | 46564819 |
Endotracheal intubation | 28.81 | 13.04 | 31 | 115384 | 2134 | 46568513 |
Blood glucose increased | 28.77 | 13.04 | 87 | 115328 | 71926 | 46498721 |
Balance disorder | 28.70 | 13.04 | 74 | 115341 | 64447 | 46506200 |
Altered state of consciousness | 28.49 | 13.04 | 11 | 115404 | 23337 | 46547310 |
Acute myeloid leukaemia | 28.32 | 13.04 | 3 | 115412 | 15775 | 46554872 |
Pulmonary arterial wedge pressure increased | 28.19 | 13.04 | 14 | 115401 | 279 | 46570368 |
Disturbance in attention | 28.18 | 13.04 | 22 | 115393 | 31538 | 46539109 |
Hernia repair | 28.14 | 13.04 | 23 | 115392 | 1115 | 46569532 |
Catheter site extravasation | 27.99 | 13.04 | 13 | 115402 | 222 | 46570425 |
Full blood count decreased | 27.89 | 13.04 | 10 | 115405 | 22201 | 46548446 |
Systemic-pulmonary artery shunt | 27.86 | 13.04 | 8 | 115407 | 29 | 46570618 |
Localised oedema | 27.67 | 13.04 | 47 | 115368 | 5022 | 46565625 |
Urinary retention | 27.58 | 13.04 | 15 | 115400 | 26046 | 46544601 |
Foot deformity | 27.51 | 13.04 | 3 | 115412 | 15422 | 46555225 |
Metastases to bone | 27.43 | 13.04 | 5 | 115410 | 17471 | 46553176 |
Accidental exposure to product | 27.32 | 13.04 | 9 | 115406 | 21072 | 46549575 |
Incorrect route of product administration | 27.25 | 13.04 | 4 | 115411 | 16379 | 46554268 |
Blood pressure systolic increased | 27.09 | 13.04 | 19 | 115396 | 28768 | 46541879 |
Therapeutic embolisation | 26.88 | 13.04 | 11 | 115404 | 136 | 46570511 |
Posterior reversible encephalopathy syndrome | 26.86 | 13.04 | 3 | 115412 | 15138 | 46555509 |
Pancreatitis acute | 26.78 | 13.04 | 14 | 115401 | 24858 | 46545789 |
Withdrawal syndrome | 26.77 | 13.04 | 6 | 115409 | 18128 | 46552519 |
Gastrostomy | 26.61 | 13.04 | 17 | 115398 | 558 | 46570089 |
Blood potassium decreased | 26.48 | 13.04 | 173 | 115242 | 37890 | 46532757 |
Sleep study | 26.45 | 13.04 | 7 | 115408 | 17 | 46570630 |
Pulmonary arterial pressure | 26.45 | 13.04 | 7 | 115408 | 17 | 46570630 |
Constipation | 26.38 | 13.04 | 289 | 115126 | 173808 | 46396839 |
Platelet count increased | 26.26 | 13.04 | 3 | 115412 | 14871 | 46555776 |
Heart valve operation | 26.11 | 13.04 | 11 | 115404 | 147 | 46570500 |
Patent ductus arteriosus repair | 25.90 | 13.04 | 7 | 115408 | 19 | 46570628 |
Hyperhidrosis | 25.87 | 13.04 | 123 | 115292 | 89185 | 46481462 |
Bradycardia | 25.84 | 13.04 | 81 | 115334 | 66217 | 46504430 |
Carbon dioxide increased | 25.47 | 13.04 | 22 | 115393 | 1152 | 46569495 |
Device programming error | 25.33 | 13.04 | 8 | 115407 | 43 | 46570604 |
Dialysis related complication | 25.24 | 13.04 | 9 | 115406 | 74 | 46570573 |
Muscular weakness | 25.16 | 13.04 | 129 | 115286 | 91715 | 46478932 |
Pneumonitis | 25.14 | 13.04 | 20 | 115395 | 28400 | 46542247 |
Device issue | 25.12 | 13.04 | 107 | 115308 | 19873 | 46550774 |
Anti factor VIII antibody test | 25.03 | 13.04 | 5 | 115410 | 0 | 46570647 |
Coronary artery compression | 25.03 | 13.04 | 5 | 115410 | 0 | 46570647 |
Cholestasis | 24.98 | 13.04 | 18 | 115397 | 26875 | 46543772 |
Type 2 diabetes mellitus | 24.87 | 13.04 | 9 | 115406 | 19866 | 46550781 |
Mouth ulceration | 24.87 | 13.04 | 18 | 115397 | 26814 | 46543833 |
Mood swings | 24.76 | 13.04 | 5 | 115410 | 16247 | 46554400 |
Infusion site rash | 24.73 | 13.04 | 20 | 115395 | 955 | 46569692 |
Lower respiratory tract infection | 24.65 | 13.04 | 63 | 115352 | 55026 | 46515621 |
Skin exfoliation | 24.64 | 13.04 | 27 | 115388 | 32911 | 46537736 |
Medication error | 24.63 | 13.04 | 24 | 115391 | 30887 | 46539760 |
Nausea | 24.54 | 13.04 | 1994 | 113421 | 685460 | 45885187 |
Breast cancer | 24.51 | 13.04 | 47 | 115368 | 45471 | 46525176 |
Jugular vein distension | 24.43 | 13.04 | 19 | 115396 | 857 | 46569790 |
Herpes zoster | 24.34 | 13.04 | 86 | 115329 | 67786 | 46502861 |
Application site pruritus | 24.31 | 13.04 | 39 | 115376 | 3974 | 46566673 |
Injection site mass | 24.27 | 13.04 | 4 | 115411 | 15036 | 46555611 |
Sinus disorder | 24.25 | 13.04 | 93 | 115322 | 16470 | 46554177 |
Ventricular septal defect repair | 24.17 | 13.04 | 6 | 115409 | 10 | 46570637 |
Tremor | 24.07 | 13.04 | 177 | 115238 | 115462 | 46455185 |
Cerebral infarction | 23.93 | 13.04 | 14 | 115401 | 23352 | 46547295 |
Carpal tunnel syndrome | 23.91 | 13.04 | 5 | 115410 | 15854 | 46554793 |
Coronary artery disease | 23.81 | 13.04 | 29 | 115386 | 33723 | 46536924 |
Sinus bradycardia | 23.79 | 13.04 | 3 | 115412 | 13779 | 46556868 |
Cardiac output decreased | 23.75 | 13.04 | 19 | 115396 | 893 | 46569754 |
Treatment noncompliance | 23.73 | 13.04 | 140 | 115275 | 29591 | 46541056 |
Drug level increased | 23.67 | 13.04 | 8 | 115407 | 18433 | 46552214 |
Myelodysplastic syndrome | 23.60 | 13.04 | 5 | 115410 | 15706 | 46554941 |
Orthostatic hypotension | 23.57 | 13.04 | 16 | 115399 | 24642 | 46546005 |
Weight increased | 23.45 | 13.04 | 552 | 114863 | 163921 | 46406726 |
Proteinuria | 23.41 | 13.04 | 6 | 115409 | 16547 | 46554100 |
Dizziness exertional | 23.37 | 13.04 | 13 | 115402 | 329 | 46570318 |
Retching | 23.11 | 13.04 | 78 | 115337 | 12979 | 46557668 |
Diagnostic procedure | 23.09 | 13.04 | 9 | 115406 | 97 | 46570550 |
Pain | 23.01 | 13.04 | 955 | 114460 | 475993 | 46094654 |
Blood bilirubin increased | 22.95 | 13.04 | 154 | 115261 | 34030 | 46536617 |
Joint stiffness | 22.84 | 13.04 | 20 | 115395 | 27088 | 46543559 |
Eczema | 22.69 | 13.04 | 11 | 115404 | 20389 | 46550258 |
Metastases to liver | 22.65 | 13.04 | 10 | 115405 | 19575 | 46551072 |
Speech disorder | 22.55 | 13.04 | 34 | 115381 | 36133 | 46534514 |
Hallucination, visual | 22.52 | 13.04 | 8 | 115407 | 17865 | 46552782 |
Application site odour | 22.42 | 13.04 | 7 | 115408 | 36 | 46570611 |
Blister | 22.40 | 13.04 | 48 | 115367 | 44583 | 46526064 |
Application site irritation | 22.39 | 13.04 | 25 | 115390 | 1794 | 46568853 |
Anxiety | 22.32 | 13.04 | 316 | 115099 | 181641 | 46389006 |
Colitis ulcerative | 22.23 | 13.04 | 8 | 115407 | 17724 | 46552923 |
Head discomfort | 22.13 | 13.04 | 66 | 115349 | 10285 | 46560362 |
Nocturnal dyspnoea | 22.04 | 13.04 | 19 | 115396 | 992 | 46569655 |
Status epilepticus | 21.94 | 13.04 | 4 | 115411 | 13975 | 46556672 |
Ataxia | 21.83 | 13.04 | 4 | 115411 | 13926 | 46556721 |
CREST syndrome | 21.82 | 13.04 | 13 | 115402 | 376 | 46570271 |
Immunoglobulin G4 related disease | 21.80 | 13.04 | 8 | 115407 | 72 | 46570575 |
Portopulmonary hypertension | 21.79 | 13.04 | 9 | 115406 | 114 | 46570533 |
Acne | 21.76 | 13.04 | 11 | 115404 | 19908 | 46550739 |
Decreased appetite | 21.67 | 13.04 | 630 | 114785 | 193206 | 46377441 |
Intentional product use issue | 21.63 | 13.04 | 63 | 115352 | 52717 | 46517930 |
Pericardial drainage | 21.63 | 13.04 | 11 | 115404 | 231 | 46570416 |
Cytomegalovirus infection | 21.40 | 13.04 | 9 | 115406 | 18135 | 46552512 |
Viral infection | 21.38 | 13.04 | 138 | 115277 | 30097 | 46540550 |
Exercise test abnormal | 21.31 | 13.04 | 9 | 115406 | 121 | 46570526 |
Generalised oedema | 21.20 | 13.04 | 81 | 115334 | 14318 | 46556329 |
Gastritis hypertrophic | 21.11 | 13.04 | 7 | 115408 | 45 | 46570602 |
Hypercalcaemia | 21.01 | 13.04 | 13 | 115402 | 21033 | 46549614 |
Femur fracture | 20.99 | 13.04 | 37 | 115378 | 36960 | 46533687 |
Hypothyroidism | 20.99 | 13.04 | 28 | 115387 | 31310 | 46539337 |
Ear tube insertion | 20.97 | 13.04 | 8 | 115407 | 81 | 46570566 |
Pulmonary arterial pressure decreased | 20.88 | 13.04 | 8 | 115407 | 82 | 46570565 |
Chronic right ventricular failure | 20.84 | 13.04 | 6 | 115409 | 22 | 46570625 |
Osteomyelitis | 20.76 | 13.04 | 15 | 115400 | 22368 | 46548279 |
Toxic skin eruption | 20.66 | 13.04 | 3 | 115412 | 12384 | 46558263 |
Echocardiogram abnormal | 20.63 | 13.04 | 18 | 115397 | 955 | 46569692 |
Pulmonary haemorrhage | 20.58 | 13.04 | 48 | 115367 | 6457 | 46564190 |
Cor pulmonale chronic | 20.56 | 13.04 | 10 | 115405 | 190 | 46570457 |
Hypomagnesaemia | 20.45 | 13.04 | 15 | 115400 | 22195 | 46548452 |
Eosinophilia | 20.42 | 13.04 | 11 | 115404 | 19206 | 46551441 |
Adverse drug reaction | 20.41 | 13.04 | 50 | 115365 | 44312 | 46526335 |
Catheter culture positive | 20.37 | 13.04 | 9 | 115406 | 136 | 46570511 |
Intervertebral disc degeneration | 20.35 | 13.04 | 4 | 115411 | 13248 | 46557399 |
Diet noncompliance | 20.30 | 13.04 | 11 | 115404 | 264 | 46570383 |
Spinal osteoarthritis | 20.26 | 13.04 | 5 | 115410 | 14146 | 46556501 |
Ischaemic stroke | 20.21 | 13.04 | 8 | 115407 | 16714 | 46553933 |
Infusion site inflammation | 20.15 | 13.04 | 10 | 115405 | 199 | 46570448 |
Injection site rash | 20.06 | 13.04 | 7 | 115408 | 15806 | 46554841 |
Increased ventricular preload | 20.02 | 13.04 | 4 | 115411 | 0 | 46570647 |
Cyst | 20.02 | 13.04 | 3 | 115412 | 12097 | 46558550 |
Vertigo | 19.99 | 13.04 | 64 | 115351 | 51984 | 46518663 |
Nightmare | 19.96 | 13.04 | 8 | 115407 | 16590 | 46554057 |
Dysgeusia | 19.95 | 13.04 | 44 | 115371 | 40447 | 46530200 |
Prescribed underdose | 19.91 | 13.04 | 3 | 115412 | 12050 | 46558597 |
Infusion site discolouration | 19.87 | 13.04 | 14 | 115401 | 542 | 46570105 |
Oxygen consumption | 19.83 | 13.04 | 8 | 115407 | 95 | 46570552 |
Nasal dryness | 19.83 | 13.04 | 33 | 115382 | 3467 | 46567180 |
Colitis | 19.73 | 13.04 | 39 | 115376 | 37308 | 46533339 |
Tubulointerstitial nephritis | 19.72 | 13.04 | 6 | 115409 | 14782 | 46555865 |
Skin operation | 19.56 | 13.04 | 5 | 115410 | 10 | 46570637 |
Musculoskeletal disorder | 19.51 | 13.04 | 7 | 115408 | 15538 | 46555109 |
Injection site warmth | 19.46 | 13.04 | 5 | 115410 | 13767 | 46556880 |
Urinary tract infection | 19.42 | 13.04 | 406 | 115009 | 219860 | 46350787 |
Hepatitis | 19.40 | 13.04 | 31 | 115384 | 32184 | 46538463 |
Blood triglycerides increased | 19.31 | 13.04 | 3 | 115412 | 11780 | 46558867 |
Breast cancer metastatic | 19.26 | 13.04 | 5 | 115410 | 13673 | 46556974 |
Staphylococcus test positive | 19.26 | 13.04 | 33 | 115382 | 3551 | 46567096 |
Protein-losing gastroenteropathy | 19.25 | 13.04 | 9 | 115406 | 156 | 46570491 |
Disorientation | 19.12 | 13.04 | 39 | 115376 | 36879 | 46533768 |
Respiratory syncytial virus infection | 19.08 | 13.04 | 39 | 115376 | 4796 | 46565851 |
Impaired work ability | 19.02 | 13.04 | 4 | 115411 | 12632 | 46558015 |
Gait disturbance | 18.99 | 13.04 | 249 | 115166 | 145014 | 46425633 |
Tenderness | 18.93 | 13.04 | 9 | 115406 | 16872 | 46553775 |
Rash erythematous | 18.91 | 13.04 | 35 | 115380 | 34315 | 46536332 |
Cataract | 18.76 | 13.04 | 54 | 115361 | 45361 | 46525286 |
Atrial fibrillation | 18.74 | 13.04 | 360 | 115055 | 103230 | 46467417 |
Tendonitis | 18.67 | 13.04 | 6 | 115409 | 14271 | 46556376 |
Blood pressure fluctuation | 18.62 | 13.04 | 29 | 115386 | 30419 | 46540228 |
Product substitution issue | 18.48 | 13.04 | 7 | 115408 | 15024 | 46555623 |
Catheter site dryness | 18.45 | 13.04 | 6 | 115409 | 36 | 46570611 |
Dry eye | 18.43 | 13.04 | 29 | 115386 | 30293 | 46540354 |
Catheter site cellulitis | 18.42 | 13.04 | 10 | 115405 | 241 | 46570406 |
Cardiac failure chronic | 18.35 | 13.04 | 32 | 115383 | 3492 | 46567155 |
Wound | 18.34 | 13.04 | 50 | 115365 | 42752 | 46527895 |
Left ventricular failure | 18.23 | 13.04 | 39 | 115376 | 4951 | 46565696 |
Cardiac flutter | 18.21 | 13.04 | 31 | 115384 | 3318 | 46567329 |
Oesophagogastric fundoplasty | 18.16 | 13.04 | 7 | 115408 | 73 | 46570574 |
Ammonia increased | 18.10 | 13.04 | 36 | 115379 | 4341 | 46566306 |
Poisoning | 18.09 | 13.04 | 6 | 115409 | 13988 | 46556659 |
Metastases to central nervous system | 18.07 | 13.04 | 3 | 115412 | 11218 | 46559429 |
Hypothermia | 18.05 | 13.04 | 4 | 115411 | 12179 | 46558468 |
Seasonal allergy | 18.01 | 13.04 | 73 | 115342 | 13261 | 46557386 |
Diplopia | 18.00 | 13.04 | 13 | 115402 | 19392 | 46551255 |
Blood alkaline phosphatase increased | 18.00 | 13.04 | 163 | 115252 | 39446 | 46531201 |
Delusion | 18.00 | 13.04 | 3 | 115412 | 11185 | 46559462 |
Pulmonary vein stenosis | 18.00 | 13.04 | 7 | 115408 | 75 | 46570572 |
Cardiac failure high output | 17.95 | 13.04 | 10 | 115405 | 254 | 46570393 |
Tracheostomy malfunction | 17.91 | 13.04 | 6 | 115409 | 40 | 46570607 |
Product complaint | 17.87 | 13.04 | 4 | 115411 | 12097 | 46558550 |
Encephalopathy | 17.81 | 13.04 | 35 | 115380 | 33554 | 46537093 |
Infusion site ulcer | 17.79 | 13.04 | 4 | 115411 | 3 | 46570644 |
Injection site haemorrhage | 17.79 | 13.04 | 15 | 115400 | 20694 | 46549953 |
Rhinorrhoea | 17.68 | 13.04 | 188 | 115227 | 47477 | 46523170 |
Right atrial pressure increased | 17.58 | 13.04 | 8 | 115407 | 130 | 46570517 |
Large intestinal polypectomy | 17.48 | 13.04 | 9 | 115406 | 194 | 46570453 |
Blood pressure abnormal | 17.40 | 13.04 | 68 | 115347 | 12149 | 46558498 |
Tracheostomy tube removal | 17.26 | 13.04 | 4 | 115411 | 4 | 46570643 |
Cavopulmonary anastomosis | 17.26 | 13.04 | 4 | 115411 | 4 | 46570643 |
Cerebrovascular accident | 17.24 | 13.04 | 163 | 115252 | 100876 | 46469771 |
Joint range of motion decreased | 17.06 | 13.04 | 8 | 115407 | 15116 | 46555531 |
Gastric antral vascular ectasia | 17.05 | 13.04 | 13 | 115402 | 569 | 46570078 |
Sudden visual loss | 17.03 | 13.04 | 5 | 115410 | 20 | 46570627 |
Mineral supplementation | 16.96 | 13.04 | 13 | 115402 | 574 | 46570073 |
Neutrophil count increased | 16.93 | 13.04 | 7 | 115408 | 14246 | 46556401 |
Metastases to lung | 16.92 | 13.04 | 3 | 115412 | 10693 | 46559954 |
Body temperature decreased | 16.90 | 13.04 | 6 | 115409 | 13403 | 46557244 |
Gastrointestinal haemorrhage | 16.88 | 13.04 | 277 | 115138 | 77096 | 46493551 |
Optic ischaemic neuropathy | 16.87 | 13.04 | 16 | 115399 | 947 | 46569700 |
Erythema | 16.82 | 13.04 | 250 | 115165 | 142570 | 46428077 |
Hypervolaemia | 16.77 | 13.04 | 21 | 115394 | 1701 | 46568946 |
Oral pain | 16.76 | 13.04 | 22 | 115393 | 24775 | 46545872 |
Biopsy | 16.74 | 13.04 | 11 | 115404 | 379 | 46570268 |
Hypercholesterolaemia | 16.65 | 13.04 | 4 | 115411 | 11526 | 46559121 |
Chronic hepatic failure | 16.64 | 13.04 | 12 | 115403 | 482 | 46570165 |
Night sweats | 16.62 | 13.04 | 26 | 115389 | 27224 | 46543423 |
Diabetes mellitus inadequate control | 16.50 | 13.04 | 6 | 115409 | 13208 | 46557439 |
Deafness | 16.45 | 13.04 | 81 | 115334 | 15987 | 46554660 |
Pulmonary valve replacement | 16.37 | 13.04 | 4 | 115411 | 6 | 46570641 |
Cardiorenal syndrome | 16.33 | 13.04 | 13 | 115402 | 607 | 46570040 |
Infusion site reaction | 16.32 | 13.04 | 21 | 115394 | 1748 | 46568899 |
Acute myocardial infarction | 16.30 | 13.04 | 34 | 115381 | 31890 | 46538757 |
Diabetes mellitus | 16.29 | 13.04 | 66 | 115349 | 49999 | 46520648 |
Right atrial dilatation | 16.28 | 13.04 | 12 | 115403 | 499 | 46570148 |
Catheter site induration | 16.25 | 13.04 | 6 | 115409 | 55 | 46570592 |
Radiotherapy | 16.19 | 13.04 | 10 | 115405 | 309 | 46570338 |
Aspartate aminotransferase increased | 16.16 | 13.04 | 279 | 115136 | 78421 | 46492226 |
Discomfort | 16.16 | 13.04 | 60 | 115355 | 46610 | 46524037 |
Pyelonephritis | 16.01 | 13.04 | 9 | 115406 | 15348 | 46555299 |
Suture insertion | 16.01 | 13.04 | 7 | 115408 | 103 | 46570544 |
Abnormal dreams | 16.00 | 13.04 | 3 | 115412 | 10276 | 46560371 |
Malignant melanoma | 15.91 | 13.04 | 3 | 115412 | 10231 | 46560416 |
Vitamin D deficiency | 15.81 | 13.04 | 4 | 115411 | 11130 | 46559517 |
Scar | 15.81 | 13.04 | 5 | 115410 | 12014 | 46558633 |
Lip swelling | 15.71 | 13.04 | 24 | 115391 | 25371 | 46545276 |
Liver function test abnormal | 15.71 | 13.04 | 180 | 115235 | 46307 | 46524340 |
Biopsy lung | 15.69 | 13.04 | 8 | 115407 | 169 | 46570478 |
Biopsy lymph gland | 15.66 | 13.04 | 5 | 115410 | 28 | 46570619 |
Metapneumovirus infection | 15.65 | 13.04 | 14 | 115401 | 768 | 46569879 |
Chemotherapy | 15.65 | 13.04 | 18 | 115397 | 1334 | 46569313 |
Leukocytosis | 15.57 | 13.04 | 21 | 115394 | 23377 | 46547270 |
Irritability | 15.49 | 13.04 | 30 | 115385 | 28916 | 46541731 |
Respiratory disorder | 15.43 | 13.04 | 118 | 115297 | 27182 | 46543465 |
No adverse event | 15.42 | 13.04 | 39 | 115376 | 34192 | 46536455 |
Coordination abnormal | 15.42 | 13.04 | 4 | 115411 | 10945 | 46559702 |
Nephrolithiasis | 15.40 | 13.04 | 37 | 115378 | 33014 | 46537633 |
Ejection fraction decreased | 15.40 | 13.04 | 13 | 115402 | 17924 | 46552723 |
Abdominal pain | 15.36 | 13.04 | 442 | 114973 | 229589 | 46341058 |
Sudden death | 15.28 | 13.04 | 55 | 115360 | 9449 | 46561198 |
Loss of personal independence in daily activities | 15.27 | 13.04 | 81 | 115334 | 57102 | 46513545 |
Biopsy kidney | 15.21 | 13.04 | 7 | 115408 | 117 | 46570530 |
Paranasal sinus discomfort | 15.16 | 13.04 | 25 | 115390 | 2607 | 46568040 |
Spinal stenosis | 15.16 | 13.04 | 6 | 115409 | 12537 | 46558110 |
Blood lactate dehydrogenase increased | 15.12 | 13.04 | 17 | 115398 | 20483 | 46550164 |
Hallucination, auditory | 15.02 | 13.04 | 4 | 115411 | 10752 | 46559895 |
Breast tumour excision | 15.02 | 13.04 | 3 | 115412 | 0 | 46570647 |
Therapy cessation | 14.99 | 13.04 | 115 | 115300 | 26514 | 46544133 |
Brain natriuretic peptide abnormal | 14.88 | 13.04 | 10 | 115405 | 358 | 46570289 |
Gastrointestinal tube insertion | 14.80 | 13.04 | 16 | 115399 | 1107 | 46569540 |
Erythema multiforme | 14.76 | 13.04 | 3 | 115412 | 9701 | 46560946 |
Muscle twitching | 14.73 | 13.04 | 9 | 115406 | 14663 | 46555984 |
Unevaluable investigation | 14.72 | 13.04 | 5 | 115410 | 35 | 46570612 |
Haemodynamic test abnormal | 14.59 | 13.04 | 5 | 115410 | 36 | 46570611 |
Mydriasis | 14.59 | 13.04 | 4 | 115411 | 10549 | 46560098 |
Psychomotor hyperactivity | 14.56 | 13.04 | 3 | 115412 | 9610 | 46561037 |
Vasculitis | 14.35 | 13.04 | 8 | 115407 | 13703 | 46556944 |
Low cardiac output syndrome | 14.35 | 13.04 | 9 | 115406 | 286 | 46570361 |
Cardiogenic shock | 14.29 | 13.04 | 79 | 115336 | 16305 | 46554342 |
Infusion site injury | 14.27 | 13.04 | 4 | 115411 | 13 | 46570634 |
Cardiac output increased | 14.25 | 13.04 | 7 | 115408 | 136 | 46570511 |
Intracardiac pressure increased | 14.25 | 13.04 | 5 | 115410 | 39 | 46570608 |
Heart valve replacement | 14.24 | 13.04 | 11 | 115404 | 491 | 46570156 |
Bacteraemia | 14.17 | 13.04 | 71 | 115344 | 14108 | 46556539 |
Tuberculosis | 13.99 | 13.04 | 4 | 115411 | 10261 | 46560386 |
Choking | 13.92 | 13.04 | 49 | 115366 | 8327 | 46562320 |
Clostridium difficile infection | 13.91 | 13.04 | 108 | 115307 | 24995 | 46545652 |
Catheter site hypersensitivity | 13.80 | 13.04 | 6 | 115409 | 87 | 46570560 |
Pulmonary thrombosis | 13.79 | 13.04 | 45 | 115370 | 7357 | 46563290 |
Anger | 13.79 | 13.04 | 6 | 115409 | 11846 | 46558801 |
Nodule | 13.78 | 13.04 | 11 | 115404 | 15594 | 46555053 |
Carbon dioxide abnormal | 13.76 | 13.04 | 7 | 115408 | 147 | 46570500 |
Haemorrhage | 13.71 | 13.04 | 201 | 115214 | 54668 | 46515979 |
Dermatitis allergic | 13.71 | 13.04 | 7 | 115408 | 12596 | 46558051 |
Throat irritation | 13.68 | 13.04 | 120 | 115295 | 28781 | 46541866 |
Chest tube insertion | 13.62 | 13.04 | 5 | 115410 | 45 | 46570602 |
Pulmonary capillary haemangiomatosis | 13.62 | 13.04 | 4 | 115411 | 16 | 46570631 |
Blood iron decreased | 13.62 | 13.04 | 59 | 115356 | 11038 | 46559609 |
Illness | 13.51 | 13.04 | 63 | 115352 | 12161 | 46558486 |
Infusion site discomfort | 13.50 | 13.04 | 12 | 115403 | 653 | 46569994 |
Tooth disorder | 13.50 | 13.04 | 23 | 115392 | 23280 | 46547367 |
Haematuria | 13.38 | 13.04 | 29 | 115386 | 26829 | 46543818 |
Arteriovenous malformation | 13.37 | 13.04 | 16 | 115399 | 1237 | 46569410 |
Product prescribing error | 13.33 | 13.04 | 18 | 115397 | 20029 | 46550618 |
Respiratory depression | 13.29 | 13.04 | 6 | 115409 | 11594 | 46559053 |
Urinary incontinence | 13.25 | 13.04 | 32 | 115383 | 28498 | 46542149 |
Atrial pressure increased | 13.25 | 13.04 | 4 | 115411 | 18 | 46570629 |
Tracheostomy infection | 13.25 | 13.04 | 4 | 115411 | 18 | 46570629 |
Angioplasty | 13.23 | 13.04 | 16 | 115399 | 1251 | 46569396 |
Restlessness | 13.19 | 13.04 | 27 | 115388 | 25497 | 46545150 |
Eye irritation | 13.12 | 13.04 | 13 | 115402 | 16601 | 46554046 |
Cardiomegaly | 13.11 | 13.04 | 81 | 115334 | 17401 | 46553246 |
Head injury | 13.10 | 13.04 | 105 | 115310 | 24531 | 46546116 |
Body temperature increased | 13.10 | 13.04 | 26 | 115389 | 24835 | 46545812 |
Sensory disturbance | 13.07 | 13.04 | 7 | 115408 | 12260 | 46558387 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Pulmonary arterial hypertension | 1095.29 | 10.99 | 509 | 73054 | 8792 | 29870123 |
Pulmonary hypertension | 776.11 | 10.99 | 518 | 73045 | 18518 | 29860397 |
Right ventricular failure | 591.83 | 10.99 | 320 | 73243 | 7716 | 29871199 |
Fluid retention | 526.85 | 10.99 | 459 | 73104 | 24539 | 29854376 |
Dyspnoea | 416.67 | 10.99 | 1766 | 71797 | 331529 | 29547386 |
Optic ischaemic neuropathy | 368.04 | 10.99 | 150 | 73413 | 1848 | 29877067 |
Pain in jaw | 354.81 | 10.99 | 270 | 73293 | 11886 | 29867029 |
Headache | 350.35 | 10.99 | 1112 | 72451 | 181194 | 29697721 |
Cyanopsia | 320.81 | 10.99 | 77 | 73486 | 103 | 29878812 |
Death | 274.82 | 10.99 | 1652 | 71911 | 355631 | 29523284 |
Erectile dysfunction | 247.51 | 10.99 | 262 | 73301 | 17840 | 29861075 |
Flushing | 244.83 | 10.99 | 331 | 73232 | 29161 | 29849754 |
Drug ineffective | 234.06 | 10.99 | 1530 | 72033 | 338857 | 29540058 |
Nasal congestion | 224.70 | 10.99 | 252 | 73311 | 18314 | 29860601 |
Erection increased | 212.39 | 10.99 | 72 | 73491 | 504 | 29878411 |
Fluid overload | 200.66 | 10.99 | 241 | 73322 | 18851 | 29860064 |
Febrile neutropenia | 183.47 | 10.99 | 23 | 73540 | 106670 | 29772245 |
Neutropenia | 175.89 | 10.99 | 49 | 73514 | 128491 | 29750424 |
Lung transplant | 171.54 | 10.99 | 87 | 73476 | 1829 | 29877086 |
Catheter management | 159.91 | 10.99 | 66 | 73497 | 841 | 29878074 |
Dyspnoea exertional | 156.16 | 10.99 | 298 | 73265 | 35132 | 29843783 |
Oxygen saturation decreased | 146.28 | 10.99 | 327 | 73236 | 43113 | 29835802 |
Catheter site erythema | 145.59 | 10.99 | 67 | 73496 | 1127 | 29877788 |
Catheterisation cardiac | 137.33 | 10.99 | 79 | 73484 | 2152 | 29876763 |
Malignant neoplasm progression | 136.13 | 10.99 | 11 | 73552 | 72276 | 29806639 |
Blindness unilateral | 131.03 | 10.99 | 95 | 73468 | 3877 | 29875038 |
Transfusion | 127.69 | 10.99 | 122 | 73441 | 7339 | 29871576 |
Infusion site pain | 127.26 | 10.99 | 80 | 73483 | 2570 | 29876345 |
Condition aggravated | 123.87 | 10.99 | 666 | 72897 | 137200 | 29741715 |
Thrombocytopenia | 118.05 | 10.99 | 98 | 73465 | 136946 | 29741969 |
Acute kidney injury | 112.76 | 10.99 | 324 | 73239 | 273518 | 29605397 |
Catheter placement | 98.91 | 10.99 | 44 | 73519 | 681 | 29878234 |
Suspected counterfeit product | 97.70 | 10.99 | 34 | 73529 | 260 | 29878655 |
Priapism | 97.61 | 10.99 | 86 | 73477 | 4657 | 29874258 |
Oxygen consumption increased | 96.76 | 10.99 | 52 | 73511 | 1236 | 29877679 |
Visual impairment | 93.45 | 10.99 | 221 | 73342 | 30217 | 29848698 |
Hospitalisation | 92.66 | 10.99 | 279 | 73284 | 44040 | 29834875 |
Prescription drug used without a prescription | 92.15 | 10.99 | 50 | 73513 | 1212 | 29877703 |
Toxicity to various agents | 90.64 | 10.99 | 187 | 73376 | 176996 | 29701919 |
Leukopenia | 89.75 | 10.99 | 15 | 73548 | 56144 | 29822771 |
Oedema | 88.33 | 10.99 | 269 | 73294 | 42724 | 29836191 |
Pulmonary arterial pressure increased | 86.96 | 10.99 | 46 | 73517 | 1058 | 29877857 |
Catheter site pruritus | 84.67 | 10.99 | 31 | 73532 | 279 | 29878636 |
Visual field defect | 84.50 | 10.99 | 77 | 73486 | 4359 | 29874556 |
Cardiac operation | 81.82 | 10.99 | 60 | 73503 | 2492 | 29876423 |
Chromatopsia | 81.51 | 10.99 | 28 | 73535 | 205 | 29878710 |
Vision blurred | 78.86 | 10.99 | 254 | 73309 | 41562 | 29837353 |
Infusion site erythema | 77.31 | 10.99 | 49 | 73514 | 1597 | 29877318 |
Pulmonary hypertensive crisis | 77.16 | 10.99 | 25 | 73538 | 149 | 29878766 |
Catheter site discharge | 76.79 | 10.99 | 34 | 73529 | 520 | 29878395 |
Catheter site pain | 71.62 | 10.99 | 40 | 73523 | 1028 | 29877887 |
Foetal exposure during pregnancy | 71.12 | 10.99 | 5 | 73558 | 36866 | 29842049 |
Syncope | 70.65 | 10.99 | 402 | 73161 | 84501 | 29794414 |
Hypoxia | 68.95 | 10.99 | 266 | 73297 | 47588 | 29831327 |
Device related infection | 67.52 | 10.99 | 137 | 73426 | 16878 | 29862037 |
Pyrexia | 67.16 | 10.99 | 436 | 73127 | 294053 | 29584862 |
Oedema peripheral | 66.85 | 10.99 | 467 | 73096 | 105365 | 29773550 |
Central venous catheterisation | 66.24 | 10.99 | 37 | 73526 | 951 | 29877964 |
Cardiac failure | 66.17 | 10.99 | 390 | 73173 | 83028 | 29795887 |
Peyronie's disease | 63.29 | 10.99 | 18 | 73545 | 63 | 29878852 |
Heart transplant | 63.16 | 10.99 | 29 | 73534 | 485 | 29878430 |
Pancytopenia | 62.49 | 10.99 | 70 | 73493 | 84982 | 29793933 |
White blood cell count decreased | 58.55 | 10.99 | 72 | 73491 | 83875 | 29795040 |
Blindness | 58.52 | 10.99 | 107 | 73456 | 12202 | 29866713 |
Retinal vein occlusion | 55.36 | 10.99 | 39 | 73524 | 1520 | 29877395 |
Anaemia | 55.29 | 10.99 | 293 | 73270 | 207699 | 29671216 |
Device alarm issue | 54.53 | 10.99 | 30 | 73533 | 748 | 29878167 |
Pain in extremity | 53.78 | 10.99 | 458 | 73105 | 109763 | 29769152 |
Mucosal inflammation | 53.78 | 10.99 | 6 | 73557 | 30488 | 29848427 |
Catheter site infection | 53.09 | 10.99 | 46 | 73517 | 2435 | 29876480 |
Drug abuse | 52.53 | 10.99 | 75 | 73488 | 81997 | 29796918 |
Bone marrow failure | 52.18 | 10.99 | 6 | 73557 | 29779 | 29849136 |
Neutrophil count decreased | 51.29 | 10.99 | 20 | 73543 | 42434 | 29836481 |
Palpitations | 51.14 | 10.99 | 190 | 73373 | 33383 | 29845532 |
Catheter site swelling | 50.68 | 10.99 | 20 | 73543 | 225 | 29878690 |
Catheter site rash | 50.49 | 10.99 | 19 | 73544 | 186 | 29878729 |
Device dislocation | 50.38 | 10.99 | 62 | 73501 | 4969 | 29873946 |
Infusion site haemorrhage | 50.18 | 10.99 | 24 | 73539 | 442 | 29878473 |
Thrombosis corpora cavernosa | 50.12 | 10.99 | 10 | 73553 | 0 | 29878915 |
Peripheral swelling | 49.35 | 10.99 | 287 | 73276 | 60787 | 29818128 |
Completed suicide | 49.12 | 10.99 | 107 | 73456 | 99385 | 29779530 |
Counterfeit product administered | 48.87 | 10.99 | 18 | 73545 | 165 | 29878750 |
Plasma cell myeloma | 48.78 | 10.99 | 36 | 73527 | 53426 | 29825489 |
Catheter site irritation | 48.74 | 10.99 | 16 | 73547 | 100 | 29878815 |
Platelet count decreased | 48.49 | 10.99 | 119 | 73444 | 106010 | 29772905 |
Infusion related reaction | 47.55 | 10.99 | 20 | 73543 | 40544 | 29838371 |
Cardiac disorder | 47.40 | 10.99 | 209 | 73354 | 39684 | 29839231 |
Transplant evaluation | 47.29 | 10.99 | 24 | 73539 | 505 | 29878410 |
Deafness unilateral | 46.62 | 10.99 | 37 | 73526 | 1731 | 29877184 |
Electrocardiogram QT prolonged | 46.51 | 10.99 | 15 | 73548 | 35820 | 29843095 |
Hyponatraemia | 46.47 | 10.99 | 58 | 73505 | 67144 | 29811771 |
Dizziness | 46.20 | 10.99 | 703 | 72860 | 194206 | 29684709 |
Self-medication | 46.02 | 10.99 | 41 | 73522 | 2253 | 29876662 |
Deafness | 45.64 | 10.99 | 87 | 73476 | 10238 | 29868677 |
Pulmonary veno-occlusive disease | 44.86 | 10.99 | 22 | 73541 | 429 | 29878486 |
Biopsy liver | 44.20 | 10.99 | 16 | 73547 | 139 | 29878776 |
Ventilation perfusion mismatch | 44.16 | 10.99 | 13 | 73550 | 53 | 29878862 |
Complication associated with device | 44.11 | 10.99 | 62 | 73501 | 5658 | 29873257 |
Blindness transient | 43.30 | 10.99 | 37 | 73526 | 1922 | 29876993 |
General physical health deterioration | 42.63 | 10.99 | 116 | 73447 | 99828 | 29779087 |
Pre-existing condition improved | 42.62 | 10.99 | 37 | 73526 | 1964 | 29876951 |
Concomitant disease aggravated | 41.66 | 10.99 | 57 | 73506 | 5072 | 29873843 |
Heart and lung transplant | 41.38 | 10.99 | 13 | 73550 | 69 | 29878846 |
Rheumatoid arthritis | 41.27 | 10.99 | 25 | 73538 | 41172 | 29837743 |
Chest pain | 41.22 | 10.99 | 456 | 73107 | 117171 | 29761744 |
Product use issue | 40.98 | 10.99 | 222 | 73341 | 45794 | 29833121 |
Transient global amnesia | 40.94 | 10.99 | 19 | 73544 | 326 | 29878589 |
Infusion site infection | 40.79 | 10.99 | 19 | 73544 | 329 | 29878586 |
Dyschromatopsia | 40.44 | 10.99 | 18 | 73545 | 279 | 29878636 |
Renal impairment | 38.75 | 10.99 | 94 | 73469 | 84090 | 29794825 |
C-reactive protein increased | 38.73 | 10.99 | 30 | 73533 | 43443 | 29835472 |
Hepatic function abnormal | 38.58 | 10.99 | 28 | 73535 | 41917 | 29836998 |
Cytomegalovirus infection | 38.54 | 10.99 | 6 | 73557 | 23668 | 29855247 |
Spinal cord infarction | 38.20 | 10.99 | 16 | 73547 | 212 | 29878703 |
Product counterfeit | 38.15 | 10.99 | 15 | 73548 | 167 | 29878748 |
Dehydration | 36.82 | 10.99 | 167 | 73396 | 123372 | 29755543 |
Visual brightness | 36.33 | 10.99 | 10 | 73553 | 30 | 29878885 |
Confusional state | 36.29 | 10.99 | 189 | 73374 | 134645 | 29744270 |
Brain natriuretic peptide increased | 36.08 | 10.99 | 47 | 73516 | 3988 | 29874927 |
Rash maculo-papular | 36.02 | 10.99 | 9 | 73554 | 25409 | 29853506 |
Pulmonary oedema | 35.74 | 10.99 | 207 | 73356 | 43768 | 29835147 |
Vascular device infection | 35.63 | 10.99 | 32 | 73531 | 1777 | 29877138 |
Stomatitis | 35.45 | 10.99 | 24 | 73539 | 37255 | 29841660 |
Oxygen therapy | 35.37 | 10.99 | 22 | 73541 | 693 | 29878222 |
Colitis | 34.85 | 10.99 | 16 | 73547 | 30804 | 29848111 |
Pruritus | 34.51 | 10.99 | 161 | 73402 | 118043 | 29760872 |
Biopsy lung | 34.34 | 10.99 | 12 | 73551 | 93 | 29878822 |
Ventricular assist device insertion | 34.32 | 10.99 | 9 | 73554 | 21 | 29878894 |
Therapy change | 34.29 | 10.99 | 37 | 73526 | 2572 | 29876343 |
Abdominal discomfort | 34.17 | 10.99 | 221 | 73342 | 48570 | 29830345 |
Retinal artery occlusion | 33.59 | 10.99 | 30 | 73533 | 1654 | 29877261 |
Hyperkalaemia | 33.39 | 10.99 | 70 | 73493 | 65940 | 29812975 |
Therapy non-responder | 33.25 | 10.99 | 152 | 73411 | 29301 | 29849614 |
Hallucination | 33.22 | 10.99 | 43 | 73520 | 49016 | 29829899 |
Disseminated intravascular coagulation | 33.11 | 10.99 | 7 | 73556 | 22164 | 29856751 |
Expired product administered | 33.09 | 10.99 | 38 | 73525 | 2831 | 29876084 |
Viral infection | 33.04 | 10.99 | 97 | 73466 | 15088 | 29863827 |
Paracentesis | 32.77 | 10.99 | 17 | 73546 | 375 | 29878540 |
Infusion site swelling | 32.65 | 10.99 | 29 | 73534 | 1587 | 29877328 |
Dermatitis contact | 32.65 | 10.99 | 40 | 73523 | 3191 | 29875724 |
Visual acuity reduced | 32.38 | 10.99 | 99 | 73464 | 15747 | 29863168 |
Exercise tolerance decreased | 31.92 | 10.99 | 43 | 73520 | 3769 | 29875146 |
Painful erection | 31.57 | 10.99 | 14 | 73549 | 215 | 29878700 |
Malaise | 31.36 | 10.99 | 580 | 72983 | 166382 | 29712533 |
Scleroderma | 31.26 | 10.99 | 26 | 73537 | 1301 | 29877614 |
Mechanical ventilation | 31.18 | 10.99 | 29 | 73534 | 1685 | 29877230 |
Interstitial lung disease | 31.15 | 10.99 | 63 | 73500 | 60134 | 29818781 |
Coma | 31.12 | 10.99 | 32 | 73531 | 40417 | 29838498 |
Lymphocyte count abnormal | 31.11 | 10.99 | 19 | 73544 | 579 | 29878336 |
Eosinophilia | 31.10 | 10.99 | 8 | 73555 | 22152 | 29856763 |
Infusion site discharge | 31.09 | 10.99 | 10 | 73553 | 58 | 29878857 |
Feeling abnormal | 30.96 | 10.99 | 242 | 73321 | 56514 | 29822401 |
Right ventricular dysfunction | 30.85 | 10.99 | 22 | 73541 | 874 | 29878041 |
Walking distance test abnormal | 30.49 | 10.99 | 12 | 73551 | 134 | 29878781 |
Device occlusion | 30.10 | 10.99 | 54 | 73509 | 6066 | 29872849 |
Loss of visual contrast sensitivity | 30.07 | 10.99 | 6 | 73557 | 0 | 29878915 |
Cardiac failure congestive | 29.90 | 10.99 | 328 | 73235 | 84079 | 29794836 |
Fracture of penis | 29.77 | 10.99 | 13 | 73550 | 192 | 29878723 |
Treatment failure | 29.55 | 10.99 | 25 | 73538 | 34654 | 29844261 |
Pulmonary vein stenosis | 29.43 | 10.99 | 9 | 73554 | 43 | 29878872 |
Sepsis | 29.20 | 10.99 | 225 | 73338 | 146170 | 29732745 |
Myalgia | 29.05 | 10.99 | 302 | 73261 | 76365 | 29802550 |
Drug reaction with eosinophilia and systemic symptoms | 28.93 | 10.99 | 17 | 73546 | 28471 | 29850444 |
Liver transplant | 28.81 | 10.99 | 35 | 73528 | 2767 | 29876148 |
Spontaneous penile erection | 28.66 | 10.99 | 13 | 73550 | 211 | 29878704 |
Septic shock | 28.50 | 10.99 | 72 | 73491 | 63535 | 29815380 |
Macrophages increased | 28.45 | 10.99 | 12 | 73551 | 162 | 29878753 |
Optic disc disorder | 28.31 | 10.99 | 9 | 73554 | 50 | 29878865 |
Tracheostomy | 27.84 | 10.99 | 19 | 73544 | 703 | 29878212 |
Cyanosis | 27.67 | 10.99 | 78 | 73485 | 11857 | 29867058 |
Osteonecrosis of jaw | 27.55 | 10.99 | 6 | 73557 | 18612 | 29860303 |
Product use in unapproved indication | 27.48 | 10.99 | 91 | 73472 | 73602 | 29805313 |
Drug interaction | 27.44 | 10.99 | 336 | 73227 | 199232 | 29679683 |
Onychomycosis | 27.25 | 10.99 | 30 | 73533 | 2133 | 29876782 |
Catheter site haemorrhage | 27.15 | 10.99 | 30 | 73533 | 2142 | 29876773 |
Medical device change | 27.09 | 10.99 | 11 | 73552 | 134 | 29878781 |
Pneumonitis | 27.02 | 10.99 | 17 | 73546 | 27437 | 29851478 |
Somnolence | 26.95 | 10.99 | 134 | 73429 | 96629 | 29782286 |
Drug resistance | 26.89 | 10.99 | 8 | 73555 | 20125 | 29858790 |
Infusion site scar | 26.79 | 10.99 | 7 | 73556 | 16 | 29878899 |
Penile curvature | 26.67 | 10.99 | 9 | 73554 | 62 | 29878853 |
Therapeutic response unexpected | 26.61 | 10.99 | 64 | 73499 | 8839 | 29870076 |
Swelling | 26.45 | 10.99 | 165 | 73398 | 35810 | 29843105 |
Cardiac ablation | 26.23 | 10.99 | 17 | 73546 | 576 | 29878339 |
Delirium | 26.11 | 10.99 | 37 | 73526 | 40594 | 29838321 |
Rash | 26.02 | 10.99 | 324 | 73239 | 191565 | 29687350 |
Weight increased | 26.02 | 10.99 | 290 | 73273 | 74623 | 29804292 |
Vascular resistance pulmonary increased | 25.94 | 10.99 | 7 | 73556 | 19 | 29878896 |
Peritonitis | 25.93 | 10.99 | 10 | 73553 | 21365 | 29857550 |
Aspiration pleural cavity | 25.76 | 10.99 | 19 | 73544 | 796 | 29878119 |
Infusion site discomfort | 25.51 | 10.99 | 9 | 73554 | 72 | 29878843 |
Metabolic acidosis | 25.19 | 10.99 | 33 | 73530 | 37428 | 29841487 |
Cardiac index increased | 25.19 | 10.99 | 7 | 73556 | 22 | 29878893 |
Retinal vascular occlusion | 25.07 | 10.99 | 10 | 73553 | 116 | 29878799 |
Hypoglossal nerve paralysis | 25.06 | 10.99 | 5 | 73558 | 0 | 29878915 |
Retinitis pigmentosa | 25.06 | 10.99 | 5 | 73558 | 0 | 29878915 |
Product contamination | 24.84 | 10.99 | 17 | 73546 | 632 | 29878283 |
Lactic acidosis | 24.81 | 10.99 | 24 | 73539 | 31189 | 29847726 |
Blood culture negative | 24.51 | 10.99 | 7 | 73556 | 25 | 29878890 |
Ejaculation disorder | 24.40 | 10.99 | 20 | 73543 | 980 | 29877935 |
Acute myeloid leukaemia | 24.33 | 10.99 | 7 | 73556 | 17999 | 29860916 |
Patent ductus arteriosus repair | 24.21 | 10.99 | 6 | 73557 | 10 | 29878905 |
Catheter site inflammation | 24.02 | 10.99 | 12 | 73551 | 244 | 29878671 |
Respiratory syncytial virus infection | 23.76 | 10.99 | 35 | 73528 | 3333 | 29875582 |
Hyperglycaemia | 23.68 | 10.99 | 31 | 73532 | 35169 | 29843746 |
Infusion site warmth | 23.66 | 10.99 | 9 | 73554 | 91 | 29878824 |
Sinus congestion | 23.65 | 10.99 | 42 | 73521 | 4680 | 29874235 |
Blood creatinine increased | 23.50 | 10.99 | 130 | 73433 | 91245 | 29787670 |
Psoriatic arthropathy | 23.48 | 10.99 | 5 | 73558 | 15756 | 29863159 |
Chorioretinopathy | 23.44 | 10.99 | 23 | 73540 | 1429 | 29877486 |
Atrial septal defect repair | 23.40 | 10.99 | 9 | 73554 | 94 | 29878821 |
Psoriasis | 23.28 | 10.99 | 43 | 73520 | 42463 | 29836452 |
Catheter removal | 23.28 | 10.99 | 11 | 73552 | 197 | 29878718 |
Anorgasmia | 23.28 | 10.99 | 16 | 73547 | 599 | 29878316 |
Infusion site irritation | 23.25 | 10.99 | 10 | 73553 | 142 | 29878773 |
Blood testosterone decreased | 23.19 | 10.99 | 40 | 73523 | 4356 | 29874559 |
Retinal vascular disorder | 22.94 | 10.99 | 10 | 73553 | 147 | 29878768 |
Cor pulmonale | 22.73 | 10.99 | 17 | 73546 | 728 | 29878187 |
Acute macular outer retinopathy | 22.72 | 10.99 | 5 | 73558 | 3 | 29878912 |
Candida infection | 22.63 | 10.99 | 5 | 73558 | 15357 | 29863558 |
Neoplasm progression | 22.59 | 10.99 | 8 | 73555 | 18015 | 29860900 |
Cardioversion | 22.57 | 10.99 | 18 | 73545 | 848 | 29878067 |
Device infusion issue | 22.36 | 10.99 | 15 | 73548 | 539 | 29878376 |
Balloon atrial septostomy | 22.31 | 10.99 | 6 | 73557 | 16 | 29878899 |
Infusion site inflammation | 22.31 | 10.99 | 7 | 73556 | 37 | 29878878 |
Penis disorder | 22.25 | 10.99 | 20 | 73543 | 1112 | 29877803 |
Optic atrophy | 22.11 | 10.99 | 17 | 73546 | 759 | 29878156 |
Pulmonary capillary haemangiomatosis | 22.05 | 10.99 | 6 | 73557 | 17 | 29878898 |
Maculopathy | 22.03 | 10.99 | 18 | 73545 | 878 | 29878037 |
Multiple organ dysfunction syndrome | 21.91 | 10.99 | 81 | 73482 | 63406 | 29815509 |
Ejaculation failure | 21.69 | 10.99 | 17 | 73546 | 781 | 29878134 |
Congestive hepatopathy | 21.59 | 10.99 | 25 | 73538 | 1879 | 29877036 |
Tumour lysis syndrome | 21.58 | 10.99 | 3 | 73560 | 12882 | 29866033 |
Dizziness exertional | 21.37 | 10.99 | 9 | 73554 | 121 | 29878794 |
Device connection issue | 21.30 | 10.99 | 14 | 73549 | 486 | 29878429 |
Hepatotoxicity | 21.18 | 10.99 | 9 | 73554 | 18136 | 29860779 |
Dysphagia | 21.14 | 10.99 | 70 | 73493 | 56628 | 29822287 |
Decreased appetite | 21.11 | 10.99 | 251 | 73312 | 149659 | 29729256 |
Carotid artery dissection | 21.04 | 10.99 | 9 | 73554 | 126 | 29878789 |
Pneumonia aspiration | 20.88 | 10.99 | 38 | 73525 | 37742 | 29841173 |
Pneumocystis jirovecii pneumonia | 20.78 | 10.99 | 8 | 73555 | 17112 | 29861803 |
Cough | 20.70 | 10.99 | 428 | 73135 | 125214 | 29753701 |
Urticaria | 20.65 | 10.99 | 67 | 73496 | 54539 | 29824376 |
Neuropathy peripheral | 20.54 | 10.99 | 96 | 73467 | 70379 | 29808536 |
Tinnitus | 20.41 | 10.99 | 86 | 73477 | 16002 | 29862913 |
Macular degeneration | 20.32 | 10.99 | 25 | 73538 | 2003 | 29876912 |
Rhinovirus infection | 20.30 | 10.99 | 30 | 73533 | 2865 | 29876050 |
Myoclonus | 20.30 | 10.99 | 4 | 73559 | 13308 | 29865607 |
Rhabdomyolysis | 20.11 | 10.99 | 84 | 73479 | 63496 | 29815419 |
Drug eruption | 19.97 | 10.99 | 9 | 73554 | 17517 | 29861398 |
Catheterisation cardiac abnormal | 19.95 | 10.99 | 7 | 73556 | 55 | 29878860 |
Blood ethanol increased | 19.91 | 10.99 | 12 | 73551 | 357 | 29878558 |
Acute respiratory failure | 19.91 | 10.99 | 120 | 73443 | 25730 | 29853185 |
Palmar-plantar erythrodysaesthesia syndrome | 19.69 | 10.99 | 6 | 73557 | 14864 | 29864051 |
Blood cholesterol increased | 19.46 | 10.99 | 88 | 73475 | 16882 | 29862033 |
Myelodysplastic syndrome | 19.36 | 10.99 | 11 | 73552 | 18767 | 29860148 |
Seizure | 19.31 | 10.99 | 152 | 73411 | 98323 | 29780592 |
Phlebotomy | 19.27 | 10.99 | 5 | 73558 | 11 | 29878904 |
Micrococcus test positive | 18.97 | 10.99 | 5 | 73558 | 12 | 29878903 |
Hyperbilirubinaemia | 18.84 | 10.99 | 9 | 73554 | 16933 | 29861982 |
Device leakage | 18.69 | 10.99 | 33 | 73530 | 3661 | 29875254 |
Photophobia | 18.58 | 10.99 | 43 | 73520 | 5793 | 29873122 |
Stent placement | 18.22 | 10.99 | 37 | 73526 | 4559 | 29874356 |
Respiratory tract infection viral | 18.22 | 10.99 | 18 | 73545 | 1128 | 29877787 |
Spontaneous intrahepatic portosystemic venous shunt | 18.16 | 10.99 | 5 | 73558 | 15 | 29878900 |
Conjunctival hyperaemia | 18.12 | 10.99 | 25 | 73538 | 2242 | 29876673 |
Depressed level of consciousness | 18.11 | 10.99 | 42 | 73521 | 38180 | 29840735 |
Bronchopulmonary aspergillosis | 18.09 | 10.99 | 4 | 73559 | 12280 | 29866635 |
Abdominal pain | 18.01 | 10.99 | 230 | 73333 | 135424 | 29743491 |
Chloropsia | 17.82 | 10.99 | 4 | 73559 | 3 | 29878912 |
Toxic epidermal necrolysis | 17.80 | 10.99 | 11 | 73552 | 17929 | 29860986 |
Executive dysfunction | 17.80 | 10.99 | 8 | 73555 | 127 | 29878788 |
Implant site extravasation | 17.75 | 10.99 | 12 | 73551 | 437 | 29878478 |
Suture insertion | 17.70 | 10.99 | 6 | 73557 | 42 | 29878873 |
Ocular vascular disorder | 17.69 | 10.99 | 8 | 73555 | 129 | 29878786 |
Suicide attempt | 17.65 | 10.99 | 40 | 73523 | 36657 | 29842258 |
Heart valve operation | 17.58 | 10.99 | 6 | 73557 | 43 | 29878872 |
Hypocalcaemia | 17.50 | 10.99 | 16 | 73547 | 21360 | 29857555 |
Product dose omission issue | 17.40 | 10.99 | 319 | 73244 | 91312 | 29787603 |
Vitreous detachment | 17.38 | 10.99 | 15 | 73548 | 790 | 29878125 |
Catheter site extravasation | 17.26 | 10.99 | 7 | 73556 | 85 | 29878830 |
Hallucination, visual | 17.25 | 10.99 | 9 | 73554 | 16104 | 29862811 |
Prostate cancer | 17.06 | 10.99 | 109 | 73454 | 23848 | 29855067 |
Unevaluable event | 17.03 | 10.99 | 135 | 73428 | 31650 | 29847265 |
Hernia repair | 16.92 | 10.99 | 17 | 73546 | 1087 | 29877828 |
Hepatitis | 16.84 | 10.99 | 18 | 73545 | 22338 | 29856577 |
Hypoacusis | 16.72 | 10.99 | 74 | 73489 | 14065 | 29864850 |
Chest discomfort | 16.67 | 10.99 | 178 | 73385 | 45302 | 29833613 |
Chronic obstructive pulmonary disease | 16.66 | 10.99 | 180 | 73383 | 45946 | 29832969 |
Colour blindness | 16.55 | 10.99 | 9 | 73554 | 219 | 29878696 |
Contraindicated product administered | 16.51 | 10.99 | 11 | 73552 | 17220 | 29861695 |
Full blood count decreased | 16.50 | 10.99 | 9 | 73554 | 15708 | 29863207 |
Pulmonary vascular resistance abnormality | 16.49 | 10.99 | 6 | 73557 | 53 | 29878862 |
Tracheitis | 16.46 | 10.99 | 13 | 73550 | 604 | 29878311 |
Blood creatine phosphokinase increased | 16.44 | 10.99 | 54 | 73509 | 43794 | 29835121 |
Acute right ventricular failure | 16.43 | 10.99 | 7 | 73556 | 97 | 29878818 |
Sedation | 16.30 | 10.99 | 10 | 73553 | 16363 | 29862552 |
Neutropenic sepsis | 16.24 | 10.99 | 4 | 73559 | 11405 | 29867510 |
Catheter site discolouration | 16.16 | 10.99 | 5 | 73558 | 25 | 29878890 |
Photopsia | 16.09 | 10.99 | 21 | 73542 | 1785 | 29877130 |
Papilloedema | 15.93 | 10.99 | 24 | 73539 | 2332 | 29876583 |
Diuretic therapy | 15.84 | 10.99 | 5 | 73558 | 27 | 29878888 |
Heart rate increased | 15.84 | 10.99 | 155 | 73408 | 38566 | 29840349 |
Pulmonary congestion | 15.84 | 10.99 | 66 | 73497 | 12221 | 29866694 |
Transplant | 15.83 | 10.99 | 13 | 73550 | 639 | 29878276 |
Infusion site vesicles | 15.81 | 10.99 | 7 | 73556 | 107 | 29878808 |
Hypotension | 15.80 | 10.99 | 622 | 72941 | 199943 | 29678972 |
Aspergillus infection | 15.72 | 10.99 | 3 | 73560 | 10211 | 29868704 |
Cardiac discomfort | 15.69 | 10.99 | 10 | 73553 | 329 | 29878586 |
Pulmonary arterial pressure abnormal | 15.61 | 10.99 | 8 | 73555 | 172 | 29878743 |
Pulmonary embolism | 15.60 | 10.99 | 120 | 73443 | 78015 | 29800900 |
Hepatocellular injury | 15.57 | 10.99 | 24 | 73539 | 25447 | 29853468 |
Encephalopathy | 15.57 | 10.99 | 35 | 73528 | 32170 | 29846745 |
Hypophagia | 15.56 | 10.99 | 19 | 73544 | 22217 | 29856698 |
Premature baby | 15.53 | 10.99 | 11 | 73552 | 16680 | 29862235 |
Device physical property issue | 15.45 | 10.99 | 13 | 73550 | 661 | 29878254 |
Therapeutic procedure | 15.36 | 10.99 | 8 | 73555 | 178 | 29878737 |
Sudden death | 15.34 | 10.99 | 77 | 73486 | 15415 | 29863500 |
Presyncope | 15.34 | 10.99 | 79 | 73484 | 15977 | 29862938 |
Polyneuropathy | 15.25 | 10.99 | 5 | 73558 | 11818 | 29867097 |
Right atrial pressure increased | 15.24 | 10.99 | 6 | 73557 | 67 | 29878848 |
Altered state of consciousness | 15.05 | 10.99 | 16 | 73547 | 19903 | 29859012 |
Viral labyrinthitis | 15.04 | 10.99 | 3 | 73560 | 0 | 29878915 |
Dyskinesia | 14.92 | 10.99 | 19 | 73544 | 21815 | 29857100 |
Lymphadenopathy | 14.87 | 10.99 | 23 | 73540 | 24353 | 29854562 |
Atrial flutter | 14.87 | 10.99 | 72 | 73491 | 14209 | 29864706 |
Inappropriate schedule of product administration | 14.84 | 10.99 | 49 | 73514 | 39679 | 29839236 |
Haemophagocytic lymphohistiocytosis | 14.81 | 10.99 | 3 | 73560 | 9788 | 29869127 |
Ileus | 14.81 | 10.99 | 10 | 73553 | 15545 | 29863370 |
Ascites | 14.80 | 10.99 | 144 | 73419 | 35777 | 29843138 |
Urinary tract infection | 14.76 | 10.99 | 113 | 73450 | 73546 | 29805369 |
Device breakage | 14.69 | 10.99 | 19 | 73544 | 1601 | 29877314 |
Deafness transitory | 14.63 | 10.99 | 5 | 73558 | 36 | 29878879 |
Lymphopenia | 14.62 | 10.99 | 7 | 73556 | 13156 | 29865759 |
Injection site pain | 14.61 | 10.99 | 33 | 73530 | 30277 | 29848638 |
Retinal infarction | 14.57 | 10.99 | 6 | 73557 | 76 | 29878839 |
Blood pressure abnormal | 14.55 | 10.99 | 44 | 73519 | 6955 | 29871960 |
Cardiac pacemaker insertion | 14.54 | 10.99 | 24 | 73539 | 2521 | 29876394 |
Deep vein thrombosis | 14.52 | 10.99 | 88 | 73475 | 60413 | 29818502 |
Chest tube insertion | 14.50 | 10.99 | 6 | 73557 | 77 | 29878838 |
Colour blindness acquired | 14.50 | 10.99 | 6 | 73557 | 77 | 29878838 |
Food interaction | 14.39 | 10.99 | 14 | 73549 | 861 | 29878054 |
Carbon dioxide increased | 14.29 | 10.99 | 15 | 73548 | 1010 | 29877905 |
N-terminal prohormone brain natriuretic peptide increased | 14.15 | 10.99 | 17 | 73546 | 1329 | 29877586 |
Mineral supplementation | 14.09 | 10.99 | 6 | 73557 | 83 | 29878832 |
Retinal haemorrhage | 14.07 | 10.99 | 34 | 73529 | 4709 | 29874206 |
Pulmonary arterial pressure decreased | 14.07 | 10.99 | 4 | 73559 | 14 | 29878901 |
Infusion site cellulitis | 14.06 | 10.99 | 5 | 73558 | 41 | 29878874 |
Blood lactate dehydrogenase increased | 14 | 10.99 | 18 | 73545 | 20583 | 29858332 |
Metastases to liver | 13.86 | 10.99 | 6 | 73557 | 11959 | 29866956 |
Chronic respiratory failure | 13.82 | 10.99 | 16 | 73547 | 1202 | 29877713 |
Intentional product misuse | 13.81 | 10.99 | 138 | 73425 | 34529 | 29844386 |
Nodular melanoma | 13.72 | 10.99 | 6 | 73557 | 89 | 29878826 |
Endarterectomy | 13.68 | 10.99 | 7 | 73556 | 150 | 29878765 |
Exposure during pregnancy | 13.67 | 10.99 | 3 | 73560 | 9258 | 29869657 |
Catheter site scab | 13.65 | 10.99 | 4 | 73559 | 16 | 29878899 |
Lymphocyte count decreased | 13.63 | 10.99 | 16 | 73547 | 19039 | 29859876 |
Mobility decreased | 13.62 | 10.99 | 27 | 73536 | 25972 | 29852943 |
Toxic skin eruption | 13.61 | 10.99 | 5 | 73558 | 11010 | 29867905 |
Blood pressure decreased | 13.60 | 10.99 | 176 | 73387 | 46899 | 29832016 |
Transaminases increased | 13.50 | 10.99 | 23 | 73540 | 23434 | 29855481 |
Sudden cardiac death | 13.47 | 10.99 | 29 | 73534 | 3723 | 29875192 |
Penile vein thrombosis | 13.46 | 10.99 | 4 | 73559 | 17 | 29878898 |
Epstein-Barr virus antibody positive | 13.38 | 10.99 | 9 | 73554 | 325 | 29878590 |
Vasodilatation | 13.36 | 10.99 | 14 | 73549 | 941 | 29877974 |
Dialysis | 13.35 | 10.99 | 58 | 73505 | 10938 | 29867977 |
Hypercalcaemia | 13.35 | 10.99 | 7 | 73556 | 12488 | 29866427 |
Therapeutic product effect delayed | 13.32 | 10.99 | 15 | 73548 | 1094 | 29877821 |
Lung assist device therapy | 13.27 | 10.99 | 4 | 73559 | 18 | 29878897 |
Schizophrenia | 13.22 | 10.99 | 3 | 73560 | 9045 | 29869870 |
Basal cell carcinoma | 13.18 | 10.99 | 12 | 73551 | 16056 | 29862859 |
Retinal tear | 13.10 | 10.99 | 12 | 73551 | 684 | 29878231 |
Anaphylactic reaction | 13.05 | 10.99 | 31 | 73532 | 27951 | 29850964 |
Renal tubular necrosis | 12.98 | 10.99 | 11 | 73552 | 15240 | 29863675 |
Sensation of blood flow | 12.96 | 10.99 | 3 | 73560 | 3 | 29878912 |
Orchidopexy | 12.96 | 10.99 | 3 | 73560 | 3 | 29878912 |
Retinal vein thrombosis | 12.90 | 10.99 | 9 | 73554 | 345 | 29878570 |
Epistaxis | 12.84 | 10.99 | 192 | 73371 | 52789 | 29826126 |
Libido decreased | 12.77 | 10.99 | 32 | 73531 | 4534 | 29874381 |
Glare | 12.77 | 10.99 | 6 | 73557 | 106 | 29878809 |
Loss of proprioception | 12.72 | 10.99 | 8 | 73555 | 257 | 29878658 |
Corneal abrasion | 12.70 | 10.99 | 8 | 73555 | 258 | 29878657 |
Constipation | 12.65 | 10.99 | 198 | 73365 | 112708 | 29766207 |
Metastases to bone | 12.60 | 10.99 | 4 | 73559 | 9654 | 29869261 |
Catheter site mass | 12.47 | 10.99 | 4 | 73559 | 23 | 29878892 |
Thoracic cavity drainage | 12.46 | 10.99 | 7 | 73556 | 182 | 29878733 |
Bradycardia | 12.44 | 10.99 | 102 | 73461 | 65424 | 29813491 |
Cor pulmonale chronic | 12.38 | 10.99 | 5 | 73558 | 60 | 29878855 |
Oesophageal variceal ligation | 12.38 | 10.99 | 5 | 73558 | 60 | 29878855 |
Internal haemorrhage | 12.38 | 10.99 | 31 | 73532 | 4391 | 29874524 |
Viral upper respiratory tract infection | 12.37 | 10.99 | 23 | 73540 | 2655 | 29876260 |
Right-to-left cardiac shunt | 12.32 | 10.99 | 4 | 73559 | 24 | 29878891 |
Emergency care | 12.32 | 10.99 | 7 | 73556 | 186 | 29878729 |
Stevens-Johnson syndrome | 12.29 | 10.99 | 15 | 73548 | 17541 | 29861374 |
Infective pulmonary exacerbation of cystic fibrosis | 12.21 | 10.99 | 3 | 73560 | 8569 | 29870346 |
Therapy cessation | 12.12 | 10.99 | 71 | 73492 | 15066 | 29863849 |
Off label use | 12.12 | 10.99 | 495 | 73068 | 248795 | 29630120 |
Optic disc haemorrhage | 12.05 | 10.99 | 4 | 73559 | 26 | 29878889 |
Infusion site abscess | 12.05 | 10.99 | 4 | 73559 | 26 | 29878889 |
Hypokalaemia | 12.04 | 10.99 | 73 | 73490 | 50119 | 29828796 |
Haemoptysis | 12.03 | 10.99 | 123 | 73440 | 30955 | 29847960 |
Orgasm abnormal | 12.01 | 10.99 | 6 | 73557 | 122 | 29878793 |
Thunderclap headache | 11.89 | 10.99 | 5 | 73558 | 67 | 29878848 |
Accident at work | 11.80 | 10.99 | 11 | 73552 | 641 | 29878274 |
Hyperthermia | 11.80 | 10.99 | 5 | 73558 | 10094 | 29868821 |
Oesophagogastroduodenoscopy | 11.80 | 10.99 | 4 | 73559 | 28 | 29878887 |
Intentional overdose | 11.79 | 10.99 | 57 | 73506 | 41424 | 29837491 |
Infusion site rash | 11.63 | 10.99 | 8 | 73555 | 300 | 29878615 |
Psychotic disorder | 11.57 | 10.99 | 22 | 73541 | 21493 | 29857422 |
Dyspnoea at rest | 11.57 | 10.99 | 22 | 73541 | 2584 | 29876331 |
Product taste abnormal | 11.55 | 10.99 | 14 | 73549 | 1104 | 29877811 |
Leukocytosis | 11.55 | 10.99 | 22 | 73541 | 21480 | 29857435 |
Exercise test abnormal | 11.44 | 10.99 | 3 | 73560 | 7 | 29878908 |
Epilepsy | 11.40 | 10.99 | 20 | 73543 | 20149 | 29858766 |
Retinal disorder | 11.24 | 10.99 | 13 | 73550 | 976 | 29877939 |
Catheter site vesicles | 11.23 | 10.99 | 4 | 73559 | 33 | 29878882 |
Vascular operation | 11.23 | 10.99 | 4 | 73559 | 33 | 29878882 |
Catheter site dermatitis | 11.16 | 10.99 | 3 | 73560 | 8 | 29878907 |
Secretion discharge | 11.13 | 10.99 | 27 | 73536 | 3748 | 29875167 |
Mitral valve replacement | 11.11 | 10.99 | 6 | 73557 | 144 | 29878771 |
Sudden hearing loss | 11.03 | 10.99 | 12 | 73551 | 842 | 29878073 |
Delusion | 11.02 | 10.99 | 8 | 73555 | 11981 | 29866934 |
Source | Code | Description |
---|---|---|
ATC | G04BE03 | GENITO URINARY SYSTEM AND SEX HORMONES UROLOGICALS UROLOGICALS Drugs used in erectile dysfunction |
FDA MoA | N0000020026 | Phosphodiesterase 5 Inhibitors |
FDA EPC | N0000175599 | Phosphodiesterase 5 Inhibitor |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D058986 | Phosphodiesterase 5 Inhibitors |
MeSH PA | D010726 | Phosphodiesterase Inhibitors |
MeSH PA | D064804 | Urological Agents |
MeSH PA | D014665 | Vasodilator Agents |
CHEBI has role | CHEBI:35620 | vasodilator |
CHEBI has role | CHEBI:71942 | pde5 inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Pulmonary arterial hypertension | indication | 11399002 | |
Impotence | indication | 397803000 | |
Induratio penis plastica | contraindication | 1335005 | DOID:8616 |
Priapism | contraindication | 6273006 | DOID:9286 |
Hearing loss | contraindication | 15188001 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Fibrosis of corpus cavernosum | contraindication | 32608004 | |
Dehydration | contraindication | 34095006 | |
Low blood pressure | contraindication | 45007003 | |
Chronic heart failure | contraindication | 48447003 | |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Aortic valve stenosis | contraindication | 60573004 | DOID:1712 |
Pulmonary veno-occlusive disease | contraindication | 89420002 | DOID:5453 |
Leukemia, disease | contraindication | 93143009 | DOID:1240 |
Multiple myeloma | contraindication | 109989006 | DOID:9538 |
Hb SS disease | contraindication | 127040003 | DOID:10923 |
Cerebrovascular accident | contraindication | 230690007 | |
Penis bent | contraindication | 249247007 | |
Esophageal dysmotility | contraindication | 266434009 | DOID:9192 |
Idiopathic hypertrophic subaortic stenosis | contraindication | 360465008 | |
Acute coronary syndrome | contraindication | 394659003 | |
Anterior ischemic optic neuropathy | contraindication | 404659001 | |
Hypertensive urgency | contraindication | 443482000 | |
Pigmentary Retinopathy | contraindication | ||
Severe Autonomic Insufficiency | contraindication | ||
Hereditary Degeneration of Retina | contraindication | ||
Life-Threatening Cardiac Arrhythmias | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.35 | acidic |
pKa2 | 7.72 | Basic |
pKa3 | 3.61 | Basic |
pKa4 | 2.92 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
cGMP-specific 3',5'-cyclic phosphodiesterase | Enzyme | INHIBITOR | IC50 | 9 | IUPHAR | CHEMBL | |||
Adenosine receptor A1 | GPCR | Ki | 6.06 | DRUG MATRIX | |||||
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha | Enzyme | WOMBAT-PK | |||||||
Solute carrier organic anion transporter family member 1B3 | Transporter | INHIBITOR | IC50 | 6.10 | IUPHAR | ||||
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | Enzyme | IC50 | 5.33 | CHEMBL | |||||
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | Enzyme | IC50 | 5.47 | CHEMBL | |||||
Phosphodiesterase 4 | Enzyme | IC50 | 5.11 | CHEMBL | |||||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 5.48 | CHEMBL | |||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Enzyme | IC50 | 4.70 | CHEMBL | |||||
Multidrug resistance-associated protein 5 | Transporter | Ki | 5.92 | CHEMBL | |||||
Adenosine receptor A2a | GPCR | Ki | 6.70 | CHEMBL | |||||
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' | Enzyme | IC50 | 7.41 | CHEMBL | |||||
Phosphodiesterase 1 | Enzyme | IC50 | 6.57 | CHEMBL | |||||
Phosphodiesterase 3 | Enzyme | IC50 | 5.15 | CHEMBL | |||||
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | Enzyme | IC50 | 5.64 | CHEMBL | |||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | Enzyme | IC50 | 5.51 | CHEMBL | |||||
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A | Enzyme | IC50 | 4 | CHEMBL | |||||
cGMP-dependent 3',5'-cyclic phosphodiesterase | Enzyme | IC50 | 4.20 | CHEMBL | |||||
Alpha-1B adrenergic receptor | GPCR | Ki | 6.09 | DRUG MATRIX | |||||
cGMP-specific 3',5'-cyclic phosphodiesterase | Enzyme | Ki | 8.74 | CHEMBL | |||||
Uncharacterized protein | Enzyme | IC50 | 5.04 | CHEMBL | |||||
cGMP-specific 3',5'-cyclic phosphodiesterase | Enzyme | IC50 | 9 | CHEMBL | |||||
Phosphodiesterase 1 | Enzyme | IC50 | 6.59 | CHEMBL | |||||
Indoleamine 2,3-dioxygenase 2 | Enzyme | IC50 | 5.35 | CHEMBL | |||||
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha | Enzyme | IC50 | 6.85 | CHEMBL | |||||
Phosphodiesterase 1 | Enzyme | IC50 | 6.40 | CHEMBL | |||||
Phosphodiesterase 6 | Enzyme | IC50 | 7.70 | CHEMBL | |||||
Phosphodiesterase 2A | Unclassified | IC50 | 4.37 | CHEMBL | |||||
Phosphodiesterase 4 | Enzyme | IC50 | 5.34 | CHEMBL | |||||
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' | Enzyme | IC50 | 7.48 | CHEMBL | |||||
cGMP-specific 3',5'-cyclic phosphodiesterase | Enzyme | IC50 | 8.22 | CHEMBL |
ID | Source |
---|---|
4024110 | VUID |
N0000022115 | NUI |
D02229 | KEGG_DRUG |
171599-83-0 | SECONDARY_CAS_RN |
4021093 | VANDF |
4024110 | VANDF |
C1614029 | UMLSCUI |
CHEBI:58987 | CHEBI |
VIA | PDB_CHEM_ID |
CHEMBL192 | ChEMBL_ID |
CHEMBL1737 | ChEMBL_ID |
D000068677 | MESH_DESCRIPTOR_UI |
4743 | IUPHAR_LIGAND_ID |
7374 | INN_ID |
DB00203 | DRUGBANK_ID |
3M7OB98Y7H | UNII |
135413523 | PUBCHEM_CID |
136411 | RXNORM |
147641 | MMSL |
194438 | MMSL |
26866 | MMSL |
29679 | MMSL |
5460 | MMSL |
69683 | MMSL |
d04299 | MMSL |
007448 | NDDF |
007449 | NDDF |
108482004 | SNOMEDCT_US |
109123009 | SNOMEDCT_US |
372572000 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Revatio | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0336 | POWDER, FOR SUSPENSION | 10 mg | ORAL | NDA | 28 sections |
Revatio | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0338 | INJECTION, SOLUTION | 0.80 mg | INTRAVENOUS | NDA | 28 sections |
Revatio | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-4190 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 28 sections |
Viagra | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-4200 | TABLET, FILM COATED | 25 mg | ORAL | NDA | 28 sections |
Viagra | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-4210 | TABLET, FILM COATED | 50 mg | ORAL | NDA | 28 sections |
Viagra | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-4220 | TABLET, FILM COATED | 100 mg | ORAL | NDA | 28 sections |
Sildenafil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5341 | TABLET, FILM COATED | 25 mg | ORAL | ANDA | 26 sections |
Sildenafil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5342 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 26 sections |
Sildenafil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5343 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 26 sections |
Sildenafil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5517 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 26 sections |
Sildenafil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1657 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 28 sections |
Sildenafil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1658 | TABLET, FILM COATED | 25 mg | ORAL | ANDA | 29 sections |
Sildenafil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1659 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 29 sections |
Sildenafil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1660 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 29 sections |
Sildenafil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-4050 | POWDER, FOR SUSPENSION | 10 mg | ORAL | ANDA | 26 sections |
SILDENULLFIL CITRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6671 | TABLET | 20 mg | ORAL | ANDA | 26 sections |
SILDENULLFIL CITRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-185 | TABLET | 20 mg | ORAL | ANDA | 26 sections |
SILDENULLFIL CITRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-186 | TABLET, FILM COATED | 25 mg | ORAL | ANDA | 19 sections |
SILDENULLFIL CITRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-187 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 19 sections |
SILDENULLFIL CITRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-188 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 19 sections |
Sildenafil | Human Prescription Drug Label | 1 | 17224-460 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 26 sections |
Sildenafil Citrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17856-8100 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 26 sections |
Viagra | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-157 | TABLET, FILM COATED | 50 mg | ORAL | NDA | 14 sections |
Viagra | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-158 | TABLET, FILM COATED | 100 mg | ORAL | NDA | 14 sections |
Sildenafil Citrate | Human Prescription Drug Label | 1 | 27241-067 | TABLET, FILM COATED | 25 mg | ORAL | ANDA | 26 sections |
Sildenafil Citrate | Human Prescription Drug Label | 1 | 27241-068 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 26 sections |
Sildenafil Citrate | Human Prescription Drug Label | 1 | 27241-069 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 26 sections |
Sildenafil | Human Prescription Drug Label | 1 | 27241-124 | TABLET | 20 mg | ORAL | ANDA | 27 sections |
Sildenafil | Human Prescription Drug Label | 1 | 27241-175 | POWDER, FOR SUSPENSION | 10 mg | ORAL | ANDA | 26 sections |
Sildenafil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 31722-136 | FOR SUSPENSION | 10 mg | ORAL | ANDA | 25 sections |