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udenafil 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| inhibitors of phosphodiesterase PDE5 with vasodilator action | 4141 | 268203-93-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
a pyrazolo-pyrimidinone similar to sildenafil; phosphodiesterase type 5 inhibitor
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,ITK,MAP3K21,MAPK7,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PRKDC | 18 | |||
| kinase-selectivity-class | BRAF,CAMK2D,PDK1,SIK2 | 4 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 31, 2005 | Korean Food and Drug Administration (KFDA) |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | G04BE11 | GENITO URINARY SYSTEM AND SEX HORMONES UROLOGICALS UROLOGICALS Drugs used in erectile dysfunction |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D010726 | Phosphodiesterase Inhibitors |
| MeSH PA | D058986 | Phosphodiesterase 5 Inhibitors |
| CHEBI has role | CHEBI:35554 | cardiovascular drug |
| CHEBI has role | CHEBI:35620 | vasodilator agent |
| CHEBI has role | CHEBI:35674 | antihypertensive agent |
Related Drugs by ATC class:
G04BE Drugs used in erectile dysfunction 9 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Impotence | indication | 397803000 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.42 | acidic |
| pKa2 | 9.92 | acidic |
| pKa3 | 8.92 | Basic |
| pKa4 | 3.71 | Basic |
| pKa5 | 2.65 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase | Enzyme | INHIBITOR | IC50 | 8.08 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
| Multidrug resistance protein 1 | Transporter | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| D10027 | KEGG_DRUG |
| CHEBI:135926 | CHEBI |
| ZUD | PDB_CHEM_ID |
| CHEMBL2103849 | ChEMBL_ID |
| C419664 | MESH_SUPPLEMENTAL_RECORD_UI |
| 11577 | IUPHAR_LIGAND_ID |
| DB06267 | DRUGBANK_ID |
| L5IB4XLY36 | UNII |
| C1742789 | UMLSCUI |
| 8551 | INN_ID |
| 135413547 | PUBCHEM_CID |
| L5IB4XLY36 | INXIGHT DRUGS |
Pharmaceutical products:
None