udenafil Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
inhibitors of phosphodiesterase PDE5 with vasodilator action 4141 268203-93-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • zydena
  • udenafil
  • DA-8159
a pyrazolo-pyrimidinone similar to sildenafil; phosphodiesterase type 5 inhibitor
  • Molecular weight: 516.66
  • Formula: C25H36N6O4S
  • CLOGP: 3.15
  • LIPINSKI: 1
  • HAC: 10
  • HDO: 2
  • TPSA: 117.92
  • ALOGS: -3.81
  • ROTB: 10

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 31, 2005 Korean Food and Drug Administration (KFDA)

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC G04BE11 GENITO URINARY SYSTEM AND SEX HORMONES
UROLOGICALS
UROLOGICALS
Drugs used in erectile dysfunction
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D058986 Phosphodiesterase 5 Inhibitors
MeSH PA D010726 Phosphodiesterase Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Impotence indication 397803000

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.42 acidic
pKa2 9.92 acidic
pKa3 8.92 Basic
pKa4 3.71 Basic
pKa5 2.65 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
cGMP-specific 3',5'-cyclic phosphodiesterase Enzyme INHIBITOR IC50 8.08 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Multidrug resistance protein 1 Transporter WOMBAT-PK

External reference:

IDSource
D10027 KEGG_DRUG
CHEBI:135926 CHEBI
CHEMBL2103849 ChEMBL_ID
C419664 MESH_SUPPLEMENTAL_RECORD_UI
11577 IUPHAR_LIGAND_ID
8551 INN_ID
DB06267 DRUGBANK_ID
L5IB4XLY36 UNII
135413547 PUBCHEM_CID
C1742789 UMLSCUI

Pharmaceutical products:

None