Stem definition | Drug id | CAS RN |
---|---|---|
inhibitors of phosphodiesterase PDE5 with vasodilator action | 4305 | 330784-47-9 |
Dose | Unit | Route |
---|---|---|
0.10 | g | O |
None
Date | Agency | Company | Orphan |
---|---|---|---|
June 21, 2013 | EMA | ||
April 27, 2012 | FDA | VIVUS |
None
None
Source | Code | Description |
---|---|---|
ATC | G04BE10 | GENITO URINARY SYSTEM AND SEX HORMONES UROLOGICALS UROLOGICALS Drugs used in erectile dysfunction |
FDA MoA | N0000020026 | Phosphodiesterase 5 Inhibitors |
FDA EPC | N0000175599 | Phosphodiesterase 5 Inhibitor |
CHEBI has role | CHEBI:35620 | vasodilator |
CHEBI has role | CHEBI:50218 | phosphodiesterase inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Impotence | indication | 397803000 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 11.01 | acidic |
pKa2 | 4.93 | Basic |
pKa3 | 3.61 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
cGMP-specific 3',5'-cyclic phosphodiesterase | Enzyme | INHIBITOR | IC50 | 8.28 | WOMBAT-PK | CHEMBL | |||
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' | Enzyme | IC50 | 6.20 | WOMBAT-PK | |||||
cGMP-specific 3',5'-cyclic phosphodiesterase | Enzyme | IC50 | 8.28 | CHEMBL |
ID | Source |
---|---|
DR5S136IVO | UNII |
D03217 | KEGG_DRUG |
4032978 | VANDF |
C2698280 | UMLSCUI |
CHEBI:66876 | CHEBI |
E6L | PDB_CHEM_ID |
CHEMBL1963681 | ChEMBL_ID |
DB06237 | DRUGBANK_ID |
9869929 | PUBCHEM_CID |
8572 | INN_ID |
C553414 | MESH_SUPPLEMENTAL_RECORD_UI |
7448 | IUPHAR_LIGAND_ID |
1291301 | RXNORM |
189434 | MMSL |
28514 | MMSL |
d07863 | MMSL |
015259 | NDDF |
703956007 | SNOMEDCT_US |
703957003 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Stendra | HUMAN PRESCRIPTION DRUG LABEL | 1 | 72384-751 | TABLET | 50 mg | ORAL | NDA | 29 sections |
Stendra | HUMAN PRESCRIPTION DRUG LABEL | 1 | 72384-752 | TABLET | 100 mg | ORAL | NDA | 29 sections |
Stendra | HUMAN PRESCRIPTION DRUG LABEL | 1 | 72384-753 | TABLET | 200 mg | ORAL | NDA | 29 sections |
Stendra | HUMAN PRESCRIPTION DRUG LABEL | 1 | 76299-320 | TABLET | 50 mg | ORAL | NDA | 29 sections |
Stendra | HUMAN PRESCRIPTION DRUG LABEL | 1 | 76299-321 | TABLET | 100 mg | ORAL | NDA | 29 sections |
Stendra | HUMAN PRESCRIPTION DRUG LABEL | 1 | 76299-322 | TABLET | 200 mg | ORAL | NDA | 29 sections |