metrizamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1788 31112-62-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • metrizamide
  • amipaque
  • telebrix
A solute for density gradient centrifugation offering higher maximum solution density without the problems of increased viscosity. It is also used as a resorbable, non-ionic contrast medium.
  • Molecular weight: 789.10
  • Formula: C18H22I3N3O8
  • CLOGP: -1.70
  • LIPINSKI: 3
  • HAC: 11
  • HDO: 6
  • TPSA: 168.66
  • ALOGS: -3.09
  • ROTB: 5
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,JAK3,KDR,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 52
kinase-selectivity-class AXL,BRAF,CDK1,CDK16,CDK2,CDK3,CDK4,CDK6,CDK7,CDK9,CHUK,CLK4,DYRK1A,EIF2AK3,EPHB4,GRK2,INSR,MAP2K6,MAP3K14,MAP3K21,MAPK7,PDK1,PIK3CD,PRKDC,STK33,SYK,TEK,TGFBR1,ZAP70 29
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Aug. 23, 1978 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC V08AB01 VARIOUS
CONTRAST MEDIA
X-RAY CONTRAST MEDIA, IODINATED
Watersoluble, nephrotropic, low osmolar X-ray contrast media
MeSH PA D003287 Contrast Media
MeSH PA D064907 Diagnostic Uses of Chemicals

Related Drugs by ATC class:

V08AB Watersoluble, nephrotropic, low osmolar X-ray contrast media 11 drugs
iobitridoliodixanoliohexoliomeproliopamidoliopentoliopromideiotrolanioversolioxaglic acidioxilan

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.26 acidic
pKa2 11.87 acidic
pKa3 12.83 acidic
pKa4 13.76 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018226 VUID
N0000146557 NUI
D01311 KEGG_DRUG
4018226 VANDF
C0025869 UMLSCUI
CHEBI:31841 CHEBI
CHEMBL462394 ChEMBL_ID
D008793 MESH_DESCRIPTOR_UI
DB01578 DRUGBANK_ID
C002587 MESH_SUPPLEMENTAL_RECORD_UI
3116 INN_ID
RHH3W8F1CO UNII
443944 PUBCHEM_CID
6920 RXNORM
464 MMSL
5104 MMSL
d01472 MMSL
002350 NDDF
414693007 SNOMEDCT_US
90733003 SNOMEDCT_US

Pharmaceutical products:

None