iotrolan 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| iodine-containing contrast media | 1470 | 79770-24-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
nonionic, isotonic contrast medium designed for intrathecal use; RN given refers to cpd without isomeric designation; DL-3-117 refers to stereoisomer; structure given in first source
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 0.23 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 1.49 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 1 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 2.03 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA | BAYER HLTHCARE |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | V08AB06 | VARIOUS CONTRAST MEDIA X-RAY CONTRAST MEDIA, IODINATED Watersoluble, nephrotropic, low osmolar X-ray contrast media |
| MeSH PA | D003287 | Contrast Media |
| MeSH PA | D064907 | Diagnostic Uses of Chemicals |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.81 | acidic |
| pKa2 | 10.19 | acidic |
| pKa3 | 10.62 | acidic |
| pKa4 | 10.97 | acidic |
| pKa5 | 11.4 | acidic |
| pKa6 | 13.25 | acidic |
| pKa7 | 13.67 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4019577 | VUID |
| N0000171578 | NUI |
| D01714 | KEGG_DRUG |
| 4019577 | VANDF |
| C0123865 | UMLSCUI |
| CHEBI:31715 | CHEBI |
| CHEMBL1200555 | ChEMBL_ID |
| DB09487 | DRUGBANK_ID |
| C033300 | MESH_SUPPLEMENTAL_RECORD_UI |
| 5179 | INN_ID |
| 16FL47B687 | UNII |
| 3738 | PUBCHEM_CID |
| 51474 | RXNORM |
| 005146 | NDDF |
| 353919004 | SNOMEDCT_US |
| 395758008 | SNOMEDCT_US |
Pharmaceutical products:
None