iomeprol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
iodine-containing contrast media 1463 78649-41-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • iomeprol
  • iomeron
  • imeron
  • Molecular weight: 777.09
  • Formula: C17H22I3N3O8
  • CLOGP: -2.31
  • LIPINSKI: 3
  • HAC: 11
  • HDO: 7
  • TPSA: 179.66
  • ALOGS: -3.12
  • ROTB: 10

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.23 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.40 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 1 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.30 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute generalised exanthematous pustulosis 140.70 60.80 30 513 10251 53338272
Rash maculo-papular 123.12 60.80 33 510 29716 53318807
Toxic skin eruption 101.23 60.80 24 519 13115 53335408
Drug reaction with eosinophilia and systemic symptoms 92.61 60.80 27 516 32773 53315750
Eosinophilia 71.04 60.80 20 523 21315 53327208

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug reaction with eosinophilia and systemic symptoms 201.31 79.49 52 376 32433 32480665

Pharmacologic Action:

SourceCodeDescription
ATC V08AB10 VARIOUS
CONTRAST MEDIA
X-RAY CONTRAST MEDIA, IODINATED
Watersoluble, nephrotropic, low osmolar X-ray contrast media
MeSH PA D003287 Contrast Media
MeSH PA D064907 Diagnostic Uses of Chemicals
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:37338 radioopaque media
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.56 acidic
pKa2 11.03 acidic
pKa3 11.52 acidic
pKa4 13.95 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01719 KEGG_DRUG
C0063810 UMLSCUI
CHEBI:31710 CHEBI
CHEMBL2107214 ChEMBL_ID
DB11705 DRUGBANK_ID
C057937 MESH_SUPPLEMENTAL_RECORD_UI
5859 INN_ID
17E17JBP8L UNII
3731 PUBCHEM_CID
006219 NDDF
356671000 SNOMEDCT_US
395753004 SNOMEDCT_US

Pharmaceutical products:

None