Stem definition | Drug id | CAS RN |
---|---|---|
iodine-containing contrast media | 1463 | 78649-41-9 |
Molecule | Description |
---|---|
Synonyms:
|
|
None
Property | Value | Reference |
---|---|---|
Vd (Volume of distribution) | 0.23 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 1.40 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 1 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 2.30 hours | Lombardo F, Berellini G, Obach RS |
None
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Acute generalised exanthematous pustulosis | 140.70 | 60.80 | 30 | 513 | 10251 | 53338272 |
Rash maculo-papular | 123.12 | 60.80 | 33 | 510 | 29716 | 53318807 |
Toxic skin eruption | 101.23 | 60.80 | 24 | 519 | 13115 | 53335408 |
Drug reaction with eosinophilia and systemic symptoms | 92.61 | 60.80 | 27 | 516 | 32773 | 53315750 |
Eosinophilia | 71.04 | 60.80 | 20 | 523 | 21315 | 53327208 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug reaction with eosinophilia and systemic symptoms | 201.31 | 79.49 | 52 | 376 | 32433 | 32480665 |
Source | Code | Description |
---|---|---|
ATC | V08AB10 | VARIOUS CONTRAST MEDIA X-RAY CONTRAST MEDIA, IODINATED Watersoluble, nephrotropic, low osmolar X-ray contrast media |
MeSH PA | D003287 | Contrast Media |
MeSH PA | D064907 | Diagnostic Uses of Chemicals |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:37338 | radioopaque media |
CHEBI has role | CHEBI:78298 | environmental contaminants |
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 10.56 | acidic |
pKa2 | 11.03 | acidic |
pKa3 | 11.52 | acidic |
pKa4 | 13.95 | acidic |
None
None
None
ID | Source |
---|---|
D01719 | KEGG_DRUG |
C0063810 | UMLSCUI |
CHEBI:31710 | CHEBI |
CHEMBL2107214 | ChEMBL_ID |
DB11705 | DRUGBANK_ID |
C057937 | MESH_SUPPLEMENTAL_RECORD_UI |
5859 | INN_ID |
17E17JBP8L | UNII |
3731 | PUBCHEM_CID |
006219 | NDDF |
356671000 | SNOMEDCT_US |
395753004 | SNOMEDCT_US |
None