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iopentol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| iodine-containing contrast media | 1466 | 89797-00-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 0.20 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 1.27 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 1 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 2.04 hours | Lombardo F, Berellini G, Obach RS |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,ACVRL1,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAPK10,MAPK7,NTRK2,PDK1,PDK2,PDK4,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,ZAP70 | 31 | |||
| kinase-selectivity-class | ALK,AURKC,AXL,BRAF,CAMK2A,CAMK2B,CAMK2D,CDK16,CDK4,CDK6,CDK9,CLK4,DYRK1B,EIF2AK3,EPHB4,FLT3,GAK,GRK2,GSK3A,GSK3B,IRAK3,MAP2K6,MAP3K21,MAP4K1,MAPK7,PDK1,PIK3CD,PRKDC,SIK2,SIK3,STK17A,STK33,SYK,TEK,TGFBR1,TTK,TYRO3,ULK1,ULK2 | 39 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | V08AB08 | VARIOUS CONTRAST MEDIA X-RAY CONTRAST MEDIA, IODINATED Watersoluble, nephrotropic, low osmolar X-ray contrast media |
| MeSH PA | D003287 | Contrast Media |
| MeSH PA | D064907 | Diagnostic Uses of Chemicals |
Related Drugs by ATC class:
V08AB Watersoluble, nephrotropic, low osmolar X-ray contrast media 11 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.73 | acidic |
| pKa2 | 11.33 | acidic |
| pKa3 | 13.7 | acidic |
| pKa4 | 13.95 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D04582 | KEGG_DRUG |
| C0063815 | UMLSCUI |
| CHEBI:135893 | CHEBI |
| CHEMBL2104783 | ChEMBL_ID |
| DB13861 | DRUGBANK_ID |
| C053571 | MESH_SUPPLEMENTAL_RECORD_UI |
| 5580 | INN_ID |
| 7D6XWX076T | UNII |
| 56016 | PUBCHEM_CID |
| 27779 | RXNORM |
| 006220 | NDDF |
Pharmaceutical products:
None