ioversol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
iodine-containing contrast media	1471	87771-40-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: ioversol joversol MP-328	Molecular weight: 807.12 Formula: C18H24I3N3O9 CLOGP: -2.73 LIPINSKI: 3 HAC: 12 HDO: 8 TPSA: 199.89 ALOGS: -2.89 ROTB: 12 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

ioversol
joversol
MP-328

Molecular weight: 807.12
Formula: C18H24I3N3O9
CLOGP: -2.73
LIPINSKI: 3
HAC: 12
HDO: 8
TPSA: 199.89
ALOGS: -2.89
ROTB: 12

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Dec. 30, 1988	FDA	LIEBEL-FLARSHEIM

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Urticaria	666.60	59.90	286	3999	129275	50471564
Sneezing	345.53	59.90	100	4185	13944	50586895
Throat irritation	334.27	59.90	117	4168	30122	50570717
Pruritus	295.91	59.90	220	4065	283348	50317491
Throat tightness	197.35	59.90	72	4213	20775	50580064
Dyspnoea	185.46	59.90	228	4057	547380	50053459
Anaphylactic shock	170.12	59.90	64	4221	20091	50580748
Contrast media reaction	151.97	59.90	31	4254	976	50599863
Chest discomfort	138.17	59.90	90	4195	92632	50508207
Erythema	132.74	59.90	105	4180	146309	50454530
Eye pruritus	117.44	59.90	43	4242	12491	50588348
Pharyngeal oedema	115.38	59.90	43	4242	13122	50587717
Laryngeal discomfort	107.84	59.90	19	4266	265	50600574
Laryngeal oedema	89.59	59.90	28	4257	5025	50595814
Air embolism	78.19	59.90	14	4271	215	50600624
Rash	77.76	59.90	135	4150	437336	50163503
Type I hypersensitivity	76.78	59.90	21	4264	2364	50598475
Cough	72.09	59.90	95	4190	241169	50359670
Eye swelling	69.57	59.90	34	4251	20110	50580729
Extravasation	66.18	59.90	18	4267	1984	50598855
Bronchospasm	63.35	59.90	29	4256	14825	50586014
Eyelid oedema	61.87	59.90	25	4260	9441	50591398

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Urticaria	357.94	45.72	146	2512	54514	29517355
Sneezing	197.56	45.72	51	2607	4363	29567506
Anaphylactic shock	192.52	45.72	64	2594	13272	29558597
Pruritus	180.17	45.72	118	2540	116731	29455138
Nephropathy toxic	176.95	45.72	57	2601	10699	29561170
Contrast media reaction	103.94	45.72	22	2636	783	29571086
Throat irritation	102.54	45.72	36	2622	8749	29563120
Air embolism	99.01	45.72	16	2642	119	29571750
Dyspnoea	84.24	45.72	123	2535	326609	29245260
Throat tightness	78.70	45.72	28	2630	7063	29564806
Erythema	71.50	45.72	57	2601	75549	29496320
Anaphylactic reaction	57.71	45.72	34	2624	27539	29544330
Laryngeal oedema	53.50	45.72	17	2641	3031	29568838
Hypersensitivity	48.05	45.72	39	2619	52864	29519005

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Urticaria	746.49	45.71	325	5303	146992	64346112
Sneezing	360.35	45.71	106	5522	15145	64477959
Anaphylactic shock	333.94	45.71	118	5510	30210	64462894
Pruritus	333.51	45.71	249	5379	312151	64180953
Throat irritation	255.76	45.71	99	5529	32612	64460492
Contrast media reaction	238.20	45.71	50	5578	1762	64491342
Dyspnoea	171.66	45.71	257	5371	718417	63774687
Erythema	163.55	45.71	133	5495	186937	64306167
Throat tightness	159.51	45.71	64	5564	23096	64470008
Laryngeal oedema	123.23	45.71	39	5589	7074	64486030
Laryngeal discomfort	121.29	45.71	23	5605	476	64492628
Pharyngeal oedema	114.15	45.71	45	5583	15486	64477618
Type I hypersensitivity	107.38	45.71	30	5598	3544	64489560
Air embolism	106.50	45.71	20	5608	392	64492712
Chest discomfort	89.70	45.71	77	5551	116029	64377075
Cyanosis	89.37	45.71	42	5586	22113	64470991
Eye pruritus	83.72	45.71	34	5594	12625	64480479
Extravasation	83.37	45.71	24	5604	3156	64489948
Bronchospasm	75.02	45.71	37	5591	21645	64471459
Rash	71.23	45.71	136	5492	458413	64034691
Eye swelling	68.21	45.71	35	5593	22246	64470858
Eyelid oedema	67.79	45.71	29	5599	12250	64480854
Anaphylactic reaction	64.39	45.71	51	5577	68613	64424491
Cough	60.17	45.71	100	5528	302048	64191056
Hypersensitivity	57.66	45.71	78	5550	196374	64296730
Procedural complication	56.71	45.71	22	5606	7243	64485861
Anaphylactoid reaction	54.17	45.71	19	5609	4719	64488385
Blood pressure decreased	52.40	45.71	50	5578	86149	64406955
Shock	50.69	45.71	35	5593	38205	64454899
Loss of consciousness	49.86	45.71	63	5565	148302	64344802
Flushing	46.62	45.71	45	5583	78603	64414501

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	V08AB07	VARIOUS CONTRAST MEDIA X-RAY CONTRAST MEDIA, IODINATED Watersoluble, nephrotropic, low osmolar X-ray contrast media
FDA MoA	N0000010258	X-Ray Contrast Activity
MeSH PA	D003287	Contrast Media
MeSH PA	D064907	Diagnostic Uses of Chemicals
FDA EPC	N0000180185	Radiographic Contrast Agent

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.63	acidic
pKa2	11.03	acidic
pKa3	11.71	acidic
pKa4	13.6	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4020983	VUID
N0000148454	NUI
D01555	KEGG_DRUG
4020983	VANDF
C0063828	UMLSCUI
CHEBI:31717	CHEBI
CHEMBL1200614	ChEMBL_ID
DB09134	DRUGBANK_ID
C054871	MESH_SUPPLEMENTAL_RECORD_UI
6007	INN_ID
N3RIB7X24K	UNII
3741	PUBCHEM_CID
27792	RXNORM
4909	MMSL
d01469	MMSL
003499	NDDF
109222009	SNOMEDCT_US
395759000	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Optiray320	HUMAN PRESCRIPTION DRUG LABEL	1	0019-1323	INJECTION	678 mg	INTRA-ARTERIAL	NDA	28 sections
Optiray320	HUMAN PRESCRIPTION DRUG LABEL	1	0019-1323	INJECTION	678 mg	INTRA-ARTERIAL	NDA	28 sections
Optiray320	HUMAN PRESCRIPTION DRUG LABEL	1	0019-1323	INJECTION	678 mg	INTRA-ARTERIAL	NDA	28 sections
Optiray320	HUMAN PRESCRIPTION DRUG LABEL	1	0019-1323	INJECTION	678 mg	INTRA-ARTERIAL	NDA	28 sections
Optiray320	HUMAN PRESCRIPTION DRUG LABEL	1	0019-1323	INJECTION	678 mg	INTRA-ARTERIAL	NDA	28 sections
Optiray320	HUMAN PRESCRIPTION DRUG LABEL	1	0019-1323	INJECTION	678 mg	INTRA-ARTERIAL	NDA	28 sections
Optiray300	HUMAN PRESCRIPTION DRUG LABEL	1	0019-1332	INJECTION	636 mg	INTRA-ARTERIAL	NDA	28 sections
Optiray300	HUMAN PRESCRIPTION DRUG LABEL	1	0019-1332	INJECTION	636 mg	INTRA-ARTERIAL	NDA	28 sections
Optiray300	HUMAN PRESCRIPTION DRUG LABEL	1	0019-1332	INJECTION	636 mg	INTRA-ARTERIAL	NDA	28 sections
Optiray300	HUMAN PRESCRIPTION DRUG LABEL	1	0019-1332	INJECTION	636 mg	INTRA-ARTERIAL	NDA	28 sections
Optiray300	HUMAN PRESCRIPTION DRUG LABEL	1	0019-1332	INJECTION	636 mg	INTRA-ARTERIAL	NDA	28 sections
Optiray300	HUMAN PRESCRIPTION DRUG LABEL	1	0019-1332	INJECTION	636 mg	INTRA-ARTERIAL	NDA	28 sections
Optiray350	HUMAN PRESCRIPTION DRUG LABEL	1	0019-1333	INJECTION	741 mg	INTRA-ARTERIAL	NDA	28 sections
Optiray350	HUMAN PRESCRIPTION DRUG LABEL	1	0019-1333	INJECTION	741 mg	INTRA-ARTERIAL	NDA	28 sections
Optiray350	HUMAN PRESCRIPTION DRUG LABEL	1	0019-1333	INJECTION	741 mg	INTRA-ARTERIAL	NDA	28 sections
Optiray350	HUMAN PRESCRIPTION DRUG LABEL	1	0019-1333	INJECTION	741 mg	INTRA-ARTERIAL	NDA	28 sections
Optiray350	HUMAN PRESCRIPTION DRUG LABEL	1	0019-1333	INJECTION	741 mg	INTRA-ARTERIAL	NDA	28 sections
Optiray350	HUMAN PRESCRIPTION DRUG LABEL	1	0019-1333	INJECTION	741 mg	INTRA-ARTERIAL	NDA	28 sections