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ioxilan 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| iodine-containing contrast media | 1473 | 107793-72-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,NTRK2,PDK1,PDK2,PDK4,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 | 46 | |||
| kinase-selectivity-class | ALK,AURKA,AURKB,AURKC,AXL,BRAF,CAMK2A,CAMK2B,CAMK2D,CDK1,CDK16,CDK2,CDK3,CDK4,CDK6,CDK7,CDK9,CLK2,CLK4,DDR1,DYRK1A,DYRK1B,EIF2AK3,EPHB4,FLT3,FLT4,FYN,GAK,GRK2,GSK3A,GSK3B,INSR,IRAK1,IRAK3,KDR,KIT,MAP2K6,MAP3K21,MAP3K7,MAP4K1,MAPK1,MAPK7,MARK4,PDK1,PIK3CB,PIK3CD,PIK3CG,PRKDC,SIK2,SIK3,STK10,STK17A,STK33,SYK,TEK,TGFBR1,TTK,TYRO3,UHMK1,ULK1,ULK2 | 61 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 21, 1995 | FDA | GUERBET |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Urticaria | 67.72 | 55.91 | 18 | 45 | 318839 | 110270397 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | V08AB12 | VARIOUS CONTRAST MEDIA X-RAY CONTRAST MEDIA, IODINATED Watersoluble, nephrotropic, low osmolar X-ray contrast media |
| FDA MoA | N0000010258 | X-Ray Contrast Activity |
| MeSH PA | D003287 | Contrast Media |
| MeSH PA | D064907 | Diagnostic Uses of Chemicals |
| FDA EPC | N0000180185 | Radiographic Contrast Agent |
Related Drugs by ATC class:
V08AB Watersoluble, nephrotropic, low osmolar X-ray contrast media 11 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.82 | acidic |
| pKa2 | 11.45 | acidic |
| pKa3 | 12.2 | acidic |
| pKa4 | 13.77 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4021131 | VUID |
| N0000148585 | NUI |
| D02161 | KEGG_DRUG |
| 4021131 | VANDF |
| C0063829 | UMLSCUI |
| CHEBI:135884 | CHEBI |
| CHEMBL1201075 | ChEMBL_ID |
| DB09135 | DRUGBANK_ID |
| C055357 | MESH_SUPPLEMENTAL_RECORD_UI |
| 6301 | INN_ID |
| A4YJ7J11TG | UNII |
| 3743 | PUBCHEM_CID |
| 27793 | RXNORM |
| d06227 | MMSL |
| 007425 | NDDF |
| 409484007 | SNOMEDCT_US |
| 409485008 | SNOMEDCT_US |
Pharmaceutical products:
None