iobitridol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
iodine-containing contrast media	1449	136949-58-1

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

iobitridol

a nonionic monomeric low-osmolality contrast medium; structure given in second source

Molecular weight: 835.17
Formula: C20H28I3N3O9
CLOGP: -2.17
LIPINSKI: 3
HAC: 12
HDO: 7
TPSA: 191.10
ALOGS: -3.03
ROTB: 12

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAPK10,MAPK7,NTRK2,PDK1,PDK2,PDK4,PIK3CA,PIK3CB,PIK3CG,PRKDC,TEK,ZAP70	25
kinase-selectivity-class	ALK,AURKA,AURKB,AURKC,AXL,BRAF,CAMK2B,CAMK2D,CDK1,CDK16,CDK2,CDK3,CDK4,CDK6,CDK7,CDK9,CLK2,CLK4,DDR1,DYRK1A,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3A,GSK3B,INSR,IRAK1,IRAK3,JAK2,KIT,MAP2K6,MAP3K21,MAP3K7,MAP4K1,MAPK1,MAPK7,MET,PDK1,PDK2,PIK3CB,PIK3CD,PIK3CG,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TYRO3	51
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug reaction with eosinophilia and systemic symptoms	176.92	119.11	41	409	42717	90585280
Acute kidney injury	148.46	119.11	56	394	320331	90307666
Rash maculo-papular	136.39	119.11	33	417	40900	90587097
Eosinophilia	121.04	119.11	28	422	28505	90599492

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug reaction with eosinophilia and systemic symptoms	204.15	90.17	61	780	42014	42578480
Rash maculo-papular	137.63	90.17	44	797	37459	42583035
Toxic skin eruption	136.14	90.17	35	806	13695	42606799
Acute kidney injury	127.63	90.17	82	759	367255	42253239
Toxic epidermal necrolysis	96.35	90.17	31	810	26719	42593775

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug reaction with eosinophilia and systemic symptoms	376.14	94.98	102	1226	81993	110505978
Acute kidney injury	275.81	94.98	138	1190	635292	109952679
Rash maculo-papular	269.45	94.98	77	1251	74145	110513826
Eosinophilia	200.50	94.98	58	1270	57878	110530093
Toxic skin eruption	157.62	94.98	41	1287	27474	110560497
Toxic epidermal necrolysis	132.44	94.98	42	1286	56685	110531286
Acute generalised exanthematous pustulosis	132.37	94.98	34	1294	21630	110566341

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	V08AB11	VARIOUS CONTRAST MEDIA X-RAY CONTRAST MEDIA, IODINATED Watersoluble, nephrotropic, low osmolar X-ray contrast media
MeSH PA	D003287	Contrast Media
MeSH PA	D064907	Diagnostic Uses of Chemicals
CHEBI has role	CHEBI:35703	xenobiotic
CHEBI has role	CHEBI:37338	radioopaque medium
CHEBI has role	CHEBI:78298	environmental contaminant
CHEBI has role	CHEBI:231911	renoprotective agent

Related Drugs by ATC class:

V08AB Watersoluble, nephrotropic, low osmolar X-ray contrast media 11 drugs

iodixanol iohexol iomeprol iopamidol iopentol iopromide iotrolan ioversol ioxaglic acid ioxilan metrizamide

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	13.71	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D01181	KEGG_DRUG
C0296806	UMLSCUI
CHEMBL2107212	ChEMBL_ID
DB12407	DRUGBANK_ID
C093233	MESH_SUPPLEMENTAL_RECORD_UI
7040	INN_ID
182ECH14UH	UNII
65985	PUBCHEM_CID
87639	RXNORM
005259	NDDF
704384003	SNOMEDCT_US
715519002	SNOMEDCT_US

Pharmaceutical products:

None