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iohexol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| iodine-containing contrast media | 1461 | 66108-95-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 95 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 4597.21 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| Vd (Volume of distribution) | 0.16 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 2 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 1 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 1.50 hours | Lombardo F, Berellini G, Obach RS |
| S (Water solubility) | 0.80 mg/mL | Bocci G, Oprea TI, Benet LZ |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,ACVRL1,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAP2K6,MAPK10,MAPK7,MAPK9,NTRK2,PDK1,PDK2,PDK4,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,ZAP70 | 35 | |||
| kinase-selectivity-class | ALK,AURKA,AURKB,AURKC,AXL,BRAF,CAMK2A,CAMK2B,CAMK2D,CDK16,CDK2,CDK3,CDK4,CDK6,CDK7,CDK9,CLK2,CLK4,DYRK1B,EIF2AK3,EPHB4,FLT3,FYN,GAK,GRK2,GSK3A,GSK3B,IRAK1,IRAK3,KDR,KIT,MAP2K6,MAP3K21,MAP3K7,MAP4K1,MAPK7,MARK4,PDK1,PIK3CB,PIK3CD,PIK3CG,PRKDC,SIK2,SIK3,STK10,STK17A,STK33,SYK,TEK,TGFBR1,TTK,TYRO3,UHMK1,ULK1,ULK2 | 55 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 26, 1985 | FDA | GE HEALTHCARE |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Sneezing | 961.14 | 29.90 | 276 | 9438 | 29593 | 90589140 |
| Urticaria | 863.30 | 29.90 | 488 | 9226 | 312246 | 90306487 |
| Contrast media reaction | 608.71 | 29.90 | 107 | 9607 | 1144 | 90617589 |
| Pruritus | 523.17 | 29.90 | 443 | 9271 | 541082 | 90077651 |
| Contrast media allergy | 506.67 | 29.90 | 106 | 9608 | 2975 | 90615758 |
| Erythema | 357.18 | 29.90 | 250 | 9464 | 228996 | 90389737 |
| Throat irritation | 356.67 | 29.90 | 149 | 9565 | 48546 | 90570187 |
| Extravasation | 281.40 | 29.90 | 65 | 9649 | 2899 | 90615834 |
| Throat tightness | 270.06 | 29.90 | 106 | 9608 | 29378 | 90589355 |
| Dyspnoea | 218.55 | 29.90 | 359 | 9355 | 880596 | 89738137 |
| Anaphylactic reaction | 175.66 | 29.90 | 112 | 9602 | 87412 | 90531321 |
| Chest discomfort | 167.73 | 29.90 | 130 | 9584 | 138235 | 90480498 |
| Chills | 147.01 | 29.90 | 118 | 9596 | 131863 | 90486870 |
| Anaphylactic shock | 136.54 | 29.90 | 67 | 9647 | 31550 | 90587183 |
| Contrast encephalopathy | 125.31 | 29.90 | 21 | 9693 | 164 | 90618569 |
| Cough | 101.12 | 29.90 | 158 | 9556 | 368804 | 90249929 |
| Eye swelling | 99.90 | 29.90 | 53 | 9661 | 29333 | 90589400 |
| Eye pruritus | 83.82 | 29.90 | 47 | 9667 | 28980 | 90589753 |
| Rash maculo-papular | 81.08 | 29.90 | 52 | 9662 | 40881 | 90577852 |
| Laryngeal oedema | 78.26 | 29.90 | 29 | 9685 | 6852 | 90611881 |
| Drug ineffective | 71.15 | 29.90 | 30 | 9684 | 1384268 | 89234465 |
| Blood pressure decreased | 68.85 | 29.90 | 60 | 9654 | 74835 | 90543898 |
| Drug reaction with eosinophilia and systemic symptoms | 64.76 | 29.90 | 46 | 9668 | 42712 | 90576021 |
| Paraesthesia oral | 64.63 | 29.90 | 41 | 9673 | 31618 | 90587115 |
| Dysphagia | 60.22 | 29.90 | 67 | 9647 | 112211 | 90506522 |
| Pharyngeal oedema | 58.88 | 29.90 | 29 | 9685 | 13742 | 90604991 |
| Sensation of foreign body | 58.62 | 29.90 | 23 | 9691 | 6343 | 90612390 |
| Tachypnoea | 57.46 | 29.90 | 33 | 9681 | 21276 | 90597457 |
| Vomiting | 55.78 | 29.90 | 198 | 9516 | 788095 | 89830638 |
| Dysphonia | 54.90 | 29.90 | 49 | 9665 | 63035 | 90555698 |
| Cyanosis | 52.11 | 29.90 | 30 | 9684 | 19425 | 90599308 |
| Swelling face | 51.47 | 29.90 | 53 | 9661 | 81299 | 90537434 |
| Loss of consciousness | 51.34 | 29.90 | 69 | 9645 | 140169 | 90478564 |
| Hypotension | 49.23 | 29.90 | 108 | 9606 | 325289 | 90293444 |
| Pharyngeal swelling | 48.74 | 29.90 | 23 | 9691 | 9921 | 90608812 |
| Nasal pruritus | 48.16 | 29.90 | 12 | 9702 | 738 | 90617995 |
| Tremor | 48.08 | 29.90 | 70 | 9644 | 153103 | 90465630 |
| Anaphylactoid reaction | 47.77 | 29.90 | 18 | 9696 | 4450 | 90614283 |
| Fatigue | 47.52 | 29.90 | 33 | 9681 | 1153990 | 89464743 |
| Nasal congestion | 46.83 | 29.90 | 51 | 9663 | 83363 | 90535370 |
| Aneurysm ruptured | 44.72 | 29.90 | 11 | 9703 | 641 | 90618092 |
| Papule | 43.86 | 29.90 | 20 | 9694 | 7982 | 90610751 |
| Flushing | 42.69 | 29.90 | 50 | 9664 | 88441 | 90530292 |
| Eyelid oedema | 42.60 | 29.90 | 22 | 9692 | 11512 | 90607221 |
| Joint swelling | 42.41 | 29.90 | 3 | 9711 | 503297 | 90115436 |
| Off label use | 42.16 | 29.90 | 34 | 9680 | 1102218 | 89516515 |
| Lip swelling | 41.79 | 29.90 | 34 | 9680 | 38576 | 90580157 |
| Alopecia | 41.58 | 29.90 | 3 | 9711 | 495068 | 90123665 |
| Ocular hyperaemia | 41.38 | 29.90 | 32 | 9682 | 33766 | 90584967 |
| Patent ductus arteriosus | 40.29 | 29.90 | 16 | 9698 | 4553 | 90614180 |
| Rash | 40.16 | 29.90 | 180 | 9534 | 795920 | 89822813 |
| Swollen tongue | 38.60 | 29.90 | 35 | 9679 | 45921 | 90572812 |
| Meningitis chemical | 36.36 | 29.90 | 8 | 9706 | 285 | 90618448 |
| Bronchospasm | 35.38 | 29.90 | 24 | 9690 | 20685 | 90598048 |
| Arthralgia | 35.09 | 29.90 | 20 | 9694 | 778502 | 89840231 |
| Air embolism | 34.43 | 29.90 | 8 | 9706 | 365 | 90618368 |
| Meningitis aseptic | 34.22 | 29.90 | 16 | 9698 | 6757 | 90611976 |
| Lacrimation increased | 33.95 | 29.90 | 26 | 9688 | 27036 | 90591697 |
| Unresponsive to stimuli | 33.93 | 29.90 | 30 | 9684 | 38091 | 90580642 |
| Angioedema | 33.54 | 29.90 | 38 | 9676 | 64838 | 90553895 |
| Local anaesthetic systemic toxicity | 33.47 | 29.90 | 13 | 9701 | 3487 | 90615246 |
| Infusion site extravasation | 33.32 | 29.90 | 18 | 9696 | 10310 | 90608423 |
| Tongue pruritus | 33.05 | 29.90 | 9 | 9705 | 784 | 90617949 |
| Laryngeal discomfort | 32.96 | 29.90 | 8 | 9706 | 441 | 90618292 |
| Hypersensitivity | 32.70 | 29.90 | 115 | 9599 | 454562 | 90164171 |
| Nasopharyngitis | 32.69 | 29.90 | 3 | 9711 | 407101 | 90211632 |
| Foaming at mouth | 32.51 | 29.90 | 10 | 9704 | 1340 | 90617393 |
| Oropharyngeal discomfort | 32.20 | 29.90 | 16 | 9698 | 7719 | 90611014 |
| Acute kidney injury | 30.25 | 29.90 | 89 | 9625 | 320298 | 90298435 |
| Rash erythematous | 30.09 | 29.90 | 36 | 9678 | 65068 | 90553665 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Urticaria | 681.24 | 27.51 | 304 | 6975 | 73732 | 42540324 |
| Sneezing | 636.55 | 27.51 | 159 | 7120 | 6204 | 42607852 |
| Contrast media reaction | 434.21 | 27.51 | 85 | 7194 | 1031 | 42613025 |
| Contrast media allergy | 412.55 | 27.51 | 77 | 7202 | 710 | 42613346 |
| Pruritus | 344.33 | 27.51 | 272 | 7007 | 188499 | 42425557 |
| Erythema | 270.01 | 27.51 | 189 | 7090 | 108604 | 42505452 |
| Extravasation | 181.39 | 27.51 | 48 | 7231 | 2342 | 42611714 |
| Anaphylactic reaction | 177.56 | 27.51 | 103 | 7176 | 42640 | 42571416 |
| Rash maculo-papular | 170.86 | 27.51 | 96 | 7183 | 37407 | 42576649 |
| Chills | 158.78 | 27.51 | 130 | 7149 | 93936 | 42520120 |
| Contrast encephalopathy | 144.17 | 27.51 | 25 | 7254 | 144 | 42613912 |
| Anaphylactic shock | 120.23 | 27.51 | 65 | 7214 | 23452 | 42590604 |
| Throat tightness | 112.51 | 27.51 | 47 | 7232 | 9552 | 42604504 |
| Throat irritation | 89.64 | 27.51 | 44 | 7235 | 12992 | 42601064 |
| Dyspnoea | 69.30 | 27.51 | 198 | 7081 | 442423 | 42171633 |
| Drug reaction with eosinophilia and systemic symptoms | 64.28 | 27.51 | 55 | 7224 | 42020 | 42572036 |
| Acute kidney injury | 62.00 | 27.51 | 169 | 7110 | 367168 | 42246888 |
| Vomiting | 61.01 | 27.51 | 145 | 7134 | 289578 | 42324478 |
| Drug ineffective | 49.63 | 27.51 | 23 | 7256 | 630174 | 41983882 |
| Blood pressure decreased | 49.07 | 27.51 | 55 | 7224 | 58277 | 42555779 |
| Death | 47.92 | 27.51 | 11 | 7268 | 471174 | 42142882 |
| Chest discomfort | 46.84 | 27.51 | 56 | 7223 | 63560 | 42550496 |
| Off label use | 46.23 | 27.51 | 26 | 7253 | 638309 | 41975747 |
| Flushing | 45.84 | 27.51 | 43 | 7236 | 36985 | 42577071 |
| Anaphylactoid shock | 43.05 | 27.51 | 11 | 7268 | 466 | 42613590 |
| Eosinophilia | 42.26 | 27.51 | 39 | 7240 | 32860 | 42581196 |
| Rash | 42.25 | 27.51 | 123 | 7156 | 276831 | 42337225 |
| Eye pruritus | 40.78 | 27.51 | 25 | 7254 | 11387 | 42602669 |
| Hypersensitivity | 39.60 | 27.51 | 55 | 7224 | 72315 | 42541741 |
| Tachypnoea | 38.65 | 27.51 | 31 | 7248 | 21631 | 42592425 |
| Oxygen saturation decreased | 36.64 | 27.51 | 50 | 7229 | 64637 | 42549419 |
| Overlap syndrome | 36.32 | 27.51 | 9 | 7270 | 336 | 42613720 |
| Rash erythematous | 35.44 | 27.51 | 35 | 7244 | 32056 | 42582000 |
| Feeling hot | 34.43 | 27.51 | 30 | 7249 | 23452 | 42590604 |
| Nasal congestion | 34.11 | 27.51 | 33 | 7246 | 29468 | 42584588 |
| Rash maculovesicular | 32.77 | 27.51 | 6 | 7273 | 49 | 42614007 |
| Eyelid oedema | 32.63 | 27.51 | 17 | 7262 | 5678 | 42608378 |
| Eye swelling | 32.43 | 27.51 | 22 | 7257 | 11898 | 42602158 |
| Blister | 32.26 | 27.51 | 31 | 7248 | 27459 | 42586597 |
| Nephropathy toxic | 31.97 | 27.51 | 25 | 7254 | 16813 | 42597243 |
| Hypotension | 31.47 | 27.51 | 106 | 7173 | 257525 | 42356531 |
| Dysphoria | 30.51 | 27.51 | 13 | 7266 | 2767 | 42611289 |
| Pallor | 29.13 | 27.51 | 30 | 7249 | 28856 | 42585200 |
| Air embolism | 28.77 | 27.51 | 7 | 7272 | 242 | 42613814 |
| Swelling face | 28.48 | 27.51 | 29 | 7250 | 27525 | 42586531 |
| Nausea | 28.25 | 27.51 | 138 | 7141 | 396661 | 42217395 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Sneezing | 1446.79 | 25.19 | 415 | 16137 | 31569 | 110541178 |
| Urticaria | 1229.85 | 25.19 | 696 | 15856 | 318161 | 110254586 |
| Contrast media reaction | 940.51 | 25.19 | 180 | 16372 | 2218 | 110570529 |
| Contrast media allergy | 829.81 | 25.19 | 172 | 16380 | 3251 | 110569496 |
| Pruritus | 780.38 | 25.19 | 663 | 15889 | 580897 | 109991850 |
| Erythema | 547.34 | 25.19 | 406 | 16146 | 291041 | 110281706 |
| Extravasation | 423.45 | 25.19 | 106 | 16446 | 4739 | 110568008 |
| Throat irritation | 395.26 | 25.19 | 182 | 16370 | 53370 | 110519377 |
| Throat tightness | 335.07 | 25.19 | 141 | 16411 | 33348 | 110539399 |
| Anaphylactic reaction | 314.83 | 25.19 | 202 | 16350 | 114098 | 110458649 |
| Chills | 294.65 | 25.19 | 237 | 16315 | 190343 | 110382404 |
| Contrast encephalopathy | 261.87 | 25.19 | 46 | 16506 | 336 | 110572411 |
| Dyspnoea | 259.65 | 25.19 | 533 | 16019 | 1106339 | 109466408 |
| Rash maculo-papular | 249.52 | 25.19 | 149 | 16403 | 74073 | 110498674 |
| Anaphylactic shock | 239.69 | 25.19 | 128 | 16424 | 51418 | 110521329 |
| Chest discomfort | 191 | 25.19 | 178 | 16374 | 173670 | 110399077 |
| Eye swelling | 128.59 | 25.19 | 73 | 16479 | 32975 | 110539772 |
| Drug reaction with eosinophilia and systemic symptoms | 124.29 | 25.19 | 101 | 16451 | 81994 | 110490753 |
| Blood pressure decreased | 113.30 | 25.19 | 111 | 16441 | 114980 | 110457767 |
| Eye pruritus | 113.18 | 25.19 | 67 | 16485 | 32708 | 110540039 |
| Drug ineffective | 109.04 | 25.19 | 46 | 16506 | 1520494 | 109052253 |
| Cough | 96.52 | 25.19 | 213 | 16339 | 461428 | 110111319 |
| Off label use | 94.47 | 25.19 | 54 | 16498 | 1500131 | 109072616 |
| Acute kidney injury | 92.39 | 25.19 | 255 | 16297 | 635175 | 109937572 |
| Vomiting | 92.17 | 25.19 | 322 | 16230 | 910353 | 109662394 |
| Laryngeal oedema | 90.42 | 25.19 | 39 | 16513 | 9768 | 110562979 |
| Tachypnoea | 89.87 | 25.19 | 62 | 16490 | 39333 | 110533414 |
| Rash | 84.50 | 25.19 | 292 | 16260 | 820672 | 109752075 |
| Flushing | 76.22 | 25.19 | 86 | 16466 | 104650 | 110468097 |
| Hypotension | 73.85 | 25.19 | 208 | 16344 | 523641 | 110049106 |
| Pharyngeal swelling | 70.68 | 25.19 | 35 | 16517 | 11997 | 110560750 |
| Loss of consciousness | 70.16 | 25.19 | 114 | 16438 | 196192 | 110376555 |
| Dysphagia | 68.71 | 25.19 | 99 | 16453 | 153501 | 110419246 |
| Cyanosis | 68.28 | 25.19 | 47 | 16505 | 29694 | 110543053 |
| Swelling face | 67.50 | 25.19 | 76 | 16476 | 92245 | 110480502 |
| Pharyngeal oedema | 65.81 | 25.19 | 37 | 16515 | 16391 | 110556356 |
| Eyelid oedema | 65.59 | 25.19 | 36 | 16516 | 15226 | 110557521 |
| Nasal congestion | 65.28 | 25.19 | 77 | 16475 | 98205 | 110474542 |
| Rash erythematous | 64.37 | 25.19 | 70 | 16482 | 81762 | 110490985 |
| Dysphonia | 63.33 | 25.19 | 67 | 16485 | 75862 | 110496885 |
| Aneurysm ruptured | 61.41 | 25.19 | 17 | 16535 | 1123 | 110571624 |
| Papule | 61.08 | 25.19 | 30 | 16522 | 10103 | 110562644 |
| Air embolism | 60.91 | 25.19 | 15 | 16537 | 625 | 110572122 |
| Paraesthesia oral | 60.81 | 25.19 | 46 | 16506 | 33625 | 110539122 |
| Nephropathy toxic | 59.75 | 25.19 | 42 | 16510 | 27436 | 110545311 |
| Anaphylactoid shock | 59.13 | 25.19 | 16 | 16536 | 970 | 110571777 |
| Angioedema | 58.63 | 25.19 | 73 | 16479 | 98427 | 110474320 |
| Lip swelling | 57.70 | 25.19 | 53 | 16499 | 50614 | 110522133 |
| Lacrimation increased | 57.49 | 25.19 | 43 | 16509 | 30907 | 110541840 |
| Sensation of foreign body | 55.32 | 25.19 | 26 | 16526 | 7949 | 110564798 |
| Dysphoria | 54.18 | 25.19 | 24 | 16528 | 6404 | 110566343 |
| Eosinophilia | 53.50 | 25.19 | 54 | 16498 | 57882 | 110514865 |
| Hypersensitivity | 52.60 | 25.19 | 156 | 16396 | 403842 | 110168905 |
| Pallor | 50.99 | 25.19 | 52 | 16500 | 56415 | 110516332 |
| Anaphylactoid reaction | 49.66 | 25.19 | 23 | 16529 | 6803 | 110565944 |
| Blood pressure immeasurable | 48.78 | 25.19 | 17 | 16535 | 2406 | 110570341 |
| Death | 48.51 | 25.19 | 22 | 16530 | 698847 | 109873900 |
| Joint swelling | 48.47 | 25.19 | 5 | 16547 | 442840 | 110129907 |
| Meningitis chemical | 47.27 | 25.19 | 11 | 16541 | 359 | 110572388 |
| Ocular hyperaemia | 44.54 | 25.19 | 41 | 16511 | 39245 | 110533502 |
| Nausea | 44.34 | 25.19 | 326 | 16226 | 1235364 | 109337383 |
| Oxygen saturation decreased | 44.09 | 25.19 | 82 | 16470 | 156900 | 110415847 |
| Cold sweat | 44.05 | 25.19 | 32 | 16520 | 21999 | 110550748 |
| Infusion site extravasation | 43.36 | 25.19 | 25 | 16527 | 11609 | 110561138 |
| Condition aggravated | 42.53 | 25.19 | 29 | 16523 | 734807 | 109837940 |
| Cardiac arrest | 42.37 | 25.19 | 92 | 16460 | 196661 | 110376086 |
| Tongue pruritus | 42.31 | 25.19 | 12 | 16540 | 866 | 110571881 |
| Nasopharyngitis | 41.77 | 25.19 | 5 | 16547 | 394356 | 110178391 |
| Nasal pruritus | 41.50 | 25.19 | 12 | 16540 | 928 | 110571819 |
| Fatigue | 40.86 | 25.19 | 75 | 16477 | 1215883 | 109356864 |
| Hyperhidrosis | 40.81 | 25.19 | 88 | 16464 | 187210 | 110385537 |
| Weight decreased | 40.70 | 25.19 | 10 | 16542 | 468047 | 110104700 |
| Toxic skin eruption | 39.82 | 25.19 | 33 | 16519 | 27482 | 110545265 |
| Arthralgia | 39.75 | 25.19 | 35 | 16517 | 779597 | 109793150 |
| Tremor | 39.55 | 25.19 | 91 | 16461 | 202141 | 110370606 |
| Pneumonia | 39.37 | 25.19 | 44 | 16508 | 876670 | 109696077 |
| Fall | 38.83 | 25.19 | 21 | 16531 | 603461 | 109969286 |
| Product dose omission issue | 36.90 | 25.19 | 3 | 16549 | 321779 | 110250968 |
| Swollen tongue | 36.33 | 25.19 | 45 | 16507 | 60317 | 110512430 |
| Unresponsive to stimuli | 35.92 | 25.19 | 46 | 16506 | 63744 | 110509003 |
| Diarrhoea | 35.90 | 25.19 | 73 | 16479 | 1139432 | 109433315 |
| Shock | 35.59 | 25.19 | 42 | 16510 | 53546 | 110519201 |
| General physical health deterioration | 35.23 | 25.19 | 10 | 16542 | 425285 | 110147462 |
| Bronchospasm | 35.14 | 25.19 | 32 | 16520 | 30207 | 110542540 |
| Insomnia | 34.86 | 25.19 | 6 | 16546 | 360584 | 110212163 |
| Tachycardia | 33.82 | 25.19 | 92 | 16460 | 226553 | 110346194 |
| Toxicity to various agents | 33.51 | 25.19 | 15 | 16537 | 480540 | 110092207 |
| Pulse abnormal | 33.40 | 25.19 | 15 | 16537 | 4134 | 110568613 |
| Rash maculovesicular | 33.24 | 25.19 | 6 | 16546 | 52 | 110572695 |
| Product use in unapproved indication | 32.74 | 25.19 | 13 | 16539 | 447364 | 110125383 |
| Face oedema | 32.37 | 25.19 | 32 | 16520 | 33437 | 110539310 |
| Pain | 31.94 | 25.19 | 59 | 16493 | 954896 | 109617851 |
| Resuscitation | 31.49 | 25.19 | 13 | 16539 | 2920 | 110569827 |
| Rash pustular | 31.17 | 25.19 | 21 | 16531 | 12808 | 110559939 |
| Foaming at mouth | 31.12 | 25.19 | 12 | 16540 | 2258 | 110570489 |
| Sinusitis | 30.83 | 25.19 | 4 | 16548 | 296684 | 110276063 |
| Product use issue | 30.54 | 25.19 | 5 | 16547 | 311690 | 110261057 |
| Injection site extravasation | 30.50 | 25.19 | 19 | 16533 | 10150 | 110562597 |
| Respiratory distress | 30.20 | 25.19 | 44 | 16508 | 68830 | 110503917 |
| Decreased appetite | 29.96 | 25.19 | 17 | 16535 | 475829 | 110096918 |
| Feeling hot | 29.95 | 25.19 | 51 | 16501 | 91055 | 110481692 |
| Hepatic enzyme increased | 29.60 | 25.19 | 6 | 16546 | 320886 | 110251861 |
| Temperature intolerance | 29.57 | 25.19 | 21 | 16531 | 13929 | 110558818 |
| No adverse event | 29.27 | 25.19 | 45 | 16507 | 73794 | 110498953 |
| Hyperpyrexia | 29.17 | 25.19 | 17 | 16535 | 8052 | 110564695 |
| Pulse absent | 28.67 | 25.19 | 19 | 16533 | 11273 | 110561474 |
| Amaurosis | 27.63 | 25.19 | 10 | 16542 | 1579 | 110571168 |
| Enanthema | 26.91 | 25.19 | 9 | 16543 | 1125 | 110571622 |
| Meningitis aseptic | 26.02 | 25.19 | 17 | 16535 | 9853 | 110562894 |
| Laryngeal discomfort | 25.91 | 25.19 | 8 | 16544 | 775 | 110571972 |
| Renal tubular necrosis | 25.59 | 25.19 | 27 | 16525 | 30448 | 110542299 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | V08AB02 | VARIOUS CONTRAST MEDIA X-RAY CONTRAST MEDIA, IODINATED Watersoluble, nephrotropic, low osmolar X-ray contrast media |
| FDA MoA | N0000010258 | X-Ray Contrast Activity |
| MeSH PA | D003287 | Contrast Media |
| FDA EPC | N0000180185 | Radiographic Contrast Agent |
| CHEBI has role | CHEBI:35554 | cardiovascular drug |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:35703 | xenobiotic |
| CHEBI has role | CHEBI:37338 | radioopaque medium |
| CHEBI has role | CHEBI:64946 | anti-HIV agent |
| CHEBI has role | CHEBI:78298 | environmental contaminant |
| CHEBI has role | CHEBI:231911 | renoprotective agent |
Related Drugs by ATC class:
V08AB Watersoluble, nephrotropic, low osmolar X-ray contrast media 11 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.73 | acidic |
| pKa2 | 11.33 | acidic |
| pKa3 | 12.2 | acidic |
| pKa4 | 13.65 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
|---|---|---|---|---|---|---|---|---|---|
| 64.7% | IOHEXOL | AMNEAL | A217737 | Nov. 13, 2025 | RX | SOLUTION | INJECTION, ORAL, RECTAL | July 26, 2026 | COMPETITIVE GENERIC THERAPY |
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4018251 | VUID |
| N0000146581 | NUI |
| D01817 | KEGG_DRUG |
| 4018251 | VANDF |
| C0022005 | UMLSCUI |
| CHEBI:31709 | CHEBI |
| CHEMBL1200455 | ChEMBL_ID |
| D007472 | MESH_DESCRIPTOR_UI |
| DB01362 | DRUGBANK_ID |
| 4848 | INN_ID |
| 4419T9MX03 | UNII |
| 3730 | PUBCHEM_CID |
| 5956 | RXNORM |
| 195194 | MMSL |
| 4904 | MMSL |
| d01456 | MMSL |
| 000673 | NDDF |
| 109218004 | SNOMEDCT_US |
| 395751002 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| OMNIPAQUE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0407-1401 | INJECTION, SOLUTION | 140 mg | INTRAVENOUS | NDA | 31 sections |
| OMNIPAQUE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0407-1411 | INJECTION, SOLUTION | 180 mg | ORAL | NDA | 31 sections |
| OMNIPAQUE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0407-1412 | INJECTION, SOLUTION | 240 mg | INTRAVENOUS | NDA | 31 sections |
| Omnipaque | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0407-1413 | INJECTION, SOLUTION | 300 mg | INTRAVENOUS | NDA | 31 sections |
| Omnipaque | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0407-1413 | INJECTION, SOLUTION | 300 mg | INTRAVENOUS | NDA | 31 sections |
| Omnipaque | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0407-1414 | INJECTION, SOLUTION | 350 mg | INTRAVENOUS | NDA | 31 sections |
| Omnipaque | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0407-1414 | INJECTION, SOLUTION | 350 mg | INTRAVENOUS | NDA | 31 sections |
| OMNIPAQUE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0407-1415 | SOLUTION | 9 mg | ORAL | NDA | 31 sections |
| OMNIPAQUE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0407-1416 | SOLUTION | 12 mg | ORAL | NDA | 31 sections |
| ORALTAG | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54702-501 | FOR SOLUTION | 4.50 g | ORAL | NDA | 19 sections |
| OMNIPAQUE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 71872-7369 | INJECTION, SOLUTION | 240 mg | INTRAVASCULAR | NDA | 31 sections |
| OMNIPAQUE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 71872-7370 | INJECTION, SOLUTION | 300 mg | RECTAL | NDA | 31 sections |
| Iohexol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 80830-2466 | INJECTION, SOLUTION | 300 mg | INTRA-ARTICULAR | ANDA | 26 sections |
| Iohexol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 80830-2467 | INJECTION, SOLUTION | 300 mg | INTRA-ARTICULAR | ANDA | 26 sections |
| Iohexol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 80830-2468 | INJECTION, SOLUTION | 300 mg | INTRA-ARTICULAR | ANDA | 26 sections |
| Iohexol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 80830-2471 | INJECTION, SOLUTION | 350 mg | INTRA-ARTICULAR | ANDA | 26 sections |
| Iohexol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 80830-2472 | INJECTION, SOLUTION | 350 mg | INTRA-ARTICULAR | ANDA | 26 sections |
| Iohexol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 80830-2473 | INJECTION, SOLUTION | 350 mg | INTRA-ARTICULAR | ANDA | 26 sections |