acyclovir 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antivirals bicyclic heterocycle compounds 85 59277-89-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • zovirax
  • acyclovir
  • aciclovir
  • acyclovir sodium
Acyclovir is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and varicella-zoster virus (VZV). The inhibitory activity of acyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts acyclovir into acyclovir monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. In vitro, acyclovir triphosphate stops replication of herpes viral DNA.
  • Molecular weight: 225.21
  • Formula: C8H11N5O3
  • CLOGP: -2.02
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 3
  • TPSA: 114.76
  • ALOGS: -1.42
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
4 g O
4 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 4 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 2.50 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 75 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 59.06 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 22.50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.71 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 4.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.85 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.50 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
March 29, 1982 FDA VALEANT BERMUDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Plasma cell myeloma 1332.77 10.18 907 135595 30415 50438207
White blood cell count decreased 716.61 10.18 1195 135307 115527 50353095
Febrile neutropenia 656.47 10.18 1042 135460 96625 50371997
Neuropathy peripheral 486.58 10.18 908 135594 95849 50372773
Platelet count decreased 481.49 10.18 925 135577 99801 50368821
Drug ineffective 439.54 10.18 979 135523 818354 49650268
Lymphocyte count decreased 434.31 10.18 440 136062 25867 50442755
Rheumatoid arthritis 394.98 10.18 43 136459 202507 50266115
Full blood count decreased 393.29 10.18 387 136115 21959 50446663
Urine abnormality 370.26 10.18 223 136279 6015 50462607
Contraindicated product administered 363.04 10.18 8 136494 148950 50319672
Neutrophil count decreased 356.74 10.18 525 135977 45501 50423121
Neutropenia 342.33 10.18 1025 135477 146940 50321682
Synovitis 304.39 10.18 6 136496 123859 50344763
Pemphigus 298.65 10.18 5 136497 120161 50348461
Pneumonia 292.94 10.18 1882 134620 376519 50092103
Thrombocytopenia 287.26 10.18 876 135626 126797 50341825
Systemic lupus erythematosus 281.42 10.18 27 136475 140595 50328027
Diarrhoea 271.62 10.18 2595 133907 585881 49882741
Laboratory test abnormal 268.21 10.18 322 136180 22886 50445736
Completed suicide 239.97 10.18 35 136467 131854 50336768
Urine leukocyte esterase positive 238.35 10.18 128 136374 2755 50465867
Pyrexia 236.97 10.18 1794 134708 378409 50090213
Urinary sediment present 230.59 10.18 111 136391 1880 50466742
Cytokine release syndrome 219.70 10.18 184 136318 8450 50460172
Arthralgia 212.66 10.18 551 135951 438151 50030471
Treatment failure 211.60 10.18 55 136447 137582 50331040
Glossodynia 204.91 10.18 33 136469 115536 50353086
Therapeutic product effect decreased 202.33 10.18 58 136444 135992 50332630
White blood cells urine positive 197.90 10.18 134 136368 4444 50464178
Crystal urine present 197.89 10.18 91 136411 1383 50467239
Red blood cells urine positive 195.85 10.18 111 136391 2664 50465958
Pain 195.22 10.18 852 135650 578051 49890571
Cytomegalovirus infection 187.82 10.18 237 136265 17725 50450897
Neurotoxicity 187.75 10.18 215 136287 14525 50454097
Constipation 178.77 10.18 979 135523 184729 50283893
Maternal exposure during pregnancy 173.90 10.18 108 136394 159670 50308952
Thrombosis 173.07 10.18 431 136071 55402 50413220
Wound 173.01 10.18 37 136465 105757 50362865
Drug intolerance 171.63 10.18 203 136299 218901 50249721
Joint swelling 169.92 10.18 249 136253 245037 50223585
Swelling 161.75 10.18 182 136320 200690 50267932
Graft versus host disease 160.19 10.18 133 136369 6033 50462589
Condition aggravated 158.83 10.18 354 136148 296704 50171918
Drug hypersensitivity 158.54 10.18 271 136231 250739 50217883
Blood urine present 156.42 10.18 183 136319 12650 50455972
Sepsis 153.10 10.18 737 135765 132188 50336434
Lymphocyte percentage decreased 151.84 10.18 94 136408 2666 50465956
Neutrophil percentage increased 150.33 10.18 93 136409 2634 50465988
Discomfort 147.35 10.18 54 136448 108326 50360296
Toxicity to various agents 146.86 10.18 216 136286 212283 50256339
Pancytopenia 146.34 10.18 529 135973 83501 50385121
Urine analysis abnormal 145.72 10.18 109 136393 4241 50464381
Arthropathy 132.71 10.18 138 136364 157768 50310854
Injection site pain 130.86 10.18 68 136434 110956 50357666
Alopecia 128.49 10.18 295 136207 244752 50223870
Pericarditis 127.66 10.18 28 136474 78661 50389961
Infusion related reaction 120.42 10.18 169 136333 169388 50299234
Intentional overdose 117.39 10.18 15 136487 62489 50406133
Bacterial test positive 112.67 10.18 97 136405 4626 50463996
Plasma cell myeloma recurrent 110.61 10.18 76 136426 2582 50466040
Abdominal discomfort 110.34 10.18 293 136209 231348 50237274
Bacterial test 108.82 10.18 56 136446 1101 50467521
Drug abuse 108.52 10.18 16 136486 59830 50408792
Encephalitis viral 107.66 10.18 62 136440 1535 50467087
Urine ketone body present 107.36 10.18 71 136431 2262 50466360
Helicobacter infection 103.57 10.18 8 136494 49694 50418928
Product use issue 103.14 10.18 152 136350 149323 50319299
Culture urine positive 99.27 10.18 79 136423 3372 50465250
Pathogen resistance 99.08 10.18 98 136404 5591 50463031
Acute graft versus host disease 95.87 10.18 82 136420 3876 50464746
Multiple organ dysfunction syndrome 94.57 10.18 325 136177 50012 50418610
Muscle spasms 94.48 10.18 621 135881 124932 50343690
Hypersensitivity 94.44 10.18 283 136219 214878 50253744
Meningoencephalitis herpetic 92.57 10.18 49 136453 1023 50467599
Cytomegalovirus viraemia 91.20 10.18 86 136416 4623 50463999
Hepatic enzyme increased 88.76 10.18 146 136356 137234 50331388
Haemoglobin urine present 87.52 10.18 43 136459 763 50467859
Acute kidney injury 85.10 10.18 965 135537 227093 50241529
Neutropenic sepsis 84.11 10.18 143 136359 14004 50454618
Acute myeloid leukaemia 82.62 10.18 147 136355 14927 50453695
Pre-engraftment immune reaction 82.15 10.18 29 136473 209 50468413
Epstein-Barr virus infection 80.68 10.18 97 136405 6900 50461722
Smooth muscle cell neoplasm 80.35 10.18 40 136462 731 50467891
Muscle injury 80.15 10.18 5 136497 37106 50431516
Sensitisation 79.80 10.18 51 136451 1531 50467091
Mucosal inflammation 79.66 10.18 264 136238 39878 50428744
Cytopenia 79.63 10.18 108 136394 8667 50459955
Red blood cell count decreased 79.56 10.18 236 136266 33599 50435023
Lymphopenia 78.86 10.18 147 136355 15474 50453148
Crystalluria 78.42 10.18 32 136470 357 50468265
Blood potassium decreased 77.84 10.18 248 136254 36697 50431925
Knee arthroplasty 76.91 10.18 5 136497 35841 50432781
Psoriatic arthropathy 75.74 10.18 17 136485 47015 50421607
Acute graft versus host disease in skin 74.07 10.18 63 136439 2955 50465667
Specific gravity urine decreased 72.66 10.18 36 136466 651 50467971
Rash 72.51 10.18 1615 134887 435856 50032766
Red cell distribution width increased 71.17 10.18 101 136401 8458 50460164
Impaired healing 70.71 10.18 51 136451 69735 50398887
Bronchopulmonary aspergillosis 69.75 10.18 94 136408 7498 50461124
Light chain analysis increased 69.71 10.18 41 136461 1057 50467565
Overdose 69.17 10.18 101 136401 99626 50368996
Ageusia 68.75 10.18 117 136385 11466 50457156
Fatigue 68.21 10.18 2437 134065 705164 49763458
Nephropathy toxic 67.14 10.18 95 136407 7934 50460688
Post transplant lymphoproliferative disorder 66.95 10.18 69 136433 4135 50464487
Off label use 66.32 10.18 892 135610 473534 49995088
Injection site reaction 66.18 10.18 26 136476 50006 50418616
Human herpesvirus 6 infection 65.19 10.18 55 136447 2551 50466071
Encephalitis cytomegalovirus 65.15 10.18 31 136471 511 50468111
Musculoskeletal stiffness 64.59 10.18 158 136344 128323 50340299
Folliculitis 63.52 10.18 14 136488 39211 50429411
Suicide attempt 63.47 10.18 30 136472 51702 50416920
Herpes simplex 63.26 10.18 87 136415 7075 50461547
Acute myeloid leukaemia recurrent 63.23 10.18 42 136460 1348 50467274
Psoriasis 62.92 10.18 56 136446 68944 50399678
Nitrite urine present 62.52 10.18 36 136466 891 50467731
Inappropriate schedule of product administration 62.32 10.18 61 136441 71770 50396852
Intentional product misuse 62.29 10.18 24 136478 46710 50421912
Acute graft versus host disease in intestine 61.53 10.18 44 136458 1595 50467027
Ejection fraction 61.31 10.18 39 136463 1161 50467461
Encephalopathy 61.00 10.18 215 136287 33496 50435126
Stem cell transplant 60.84 10.18 44 136458 1624 50466998
Unevaluable event 60.03 10.18 265 136237 45801 50422821
Wrong technique in product usage process 59.67 10.18 38 136464 55472 50413150
Polycystic ovaries 59.22 10.18 51 136451 2433 50466189
Injection site erythema 59.04 10.18 69 136433 74867 50393755
Plasmacytoma 58.97 10.18 50 136452 2335 50466287
Monocyte percentage increased 58.65 10.18 36 136466 1005 50467617
Drug interaction 58.60 10.18 308 136194 199313 50269309
Hip arthroplasty 57.87 10.18 7 136495 30422 50438200
Irritable bowel syndrome 56.98 10.18 34 136468 51407 50417215
Blood creatinine increased 56.82 10.18 376 136126 75784 50392838
Suicidal ideation 56.73 10.18 40 136462 55345 50413277
Deep vein thrombosis 55.96 10.18 364 136138 72940 50395682
Therapeutic product effect incomplete 54.78 10.18 102 136400 91413 50377209
Haemoglobin decreased 54.20 10.18 553 135949 126663 50341959
Multiple allergies 53.59 10.18 88 136414 8375 50460247
Mobility decreased 53.47 10.18 83 136419 79865 50388757
Sleep disorder due to general medical condition, insomnia type 53.47 10.18 10 136492 31437 50437185
Toxoplasmosis 53.10 10.18 38 136464 1379 50467243
Renal disorder 52.88 10.18 179 136323 27326 50441296
Encephalitis 52.60 10.18 81 136421 7299 50461323
Type 2 diabetes mellitus 52.28 10.18 14 136488 34361 50434261
Adverse drug reaction 52.24 10.18 290 136212 54932 50413690
Injection site bruising 52.22 10.18 17 136485 36751 50431871
Blood test abnormal 51.58 10.18 102 136400 11217 50457405
Cytomegalovirus test positive 51.47 10.18 48 136454 2544 50466078
Seasonal allergy 50.49 10.18 118 136384 14558 50454064
Pneumonia fungal 49.99 10.18 60 136442 4260 50464362
Tumour lysis syndrome 49.49 10.18 79 136423 7342 50461280
Immune effector cell-associated neurotoxicity syndrome 48.13 10.18 33 136469 1117 50467505
Ill-defined disorder 47.89 10.18 46 136456 54608 50414014
Herpes zoster 47.78 10.18 341 136161 70445 50398177
Rhabdomyolysis 47.31 10.18 23 136479 39004 50429618
Hypoglycaemia 47.06 10.18 45 136457 53536 50415086
Mean cell haemoglobin decreased 46.64 10.18 51 136451 3272 50465350
Septic shock 46.16 10.18 288 136214 56887 50411735
Aspergillus infection 46.02 10.18 73 136429 6748 50461874
Thyroxine free increased 45.89 10.18 28 136474 773 50467849
Clostridium difficile colitis 45.81 10.18 128 136374 17614 50451008
Intentional product use issue 45.79 10.18 86 136416 76832 50391790
Respiratory syncytial virus infection 45.09 10.18 62 136440 5040 50463582
Intentional self-injury 44.74 10.18 5 136497 23107 50445515
Injection site swelling 44.34 10.18 29 136473 41744 50426878
Factor XIII deficiency 43.96 10.18 14 136488 70 50468552
Chronic graft versus host disease 43.76 10.18 46 136456 2821 50465801
Myocardial infarction 43.54 10.18 111 136391 88916 50379706
Influenza 43.42 10.18 400 136102 89138 50379484
Anaphylactic reaction 43.41 10.18 49 136453 54006 50414616
Cytomegalovirus infection reactivation 43.38 10.18 44 136458 2587 50466035
Disseminated mucormycosis 43.14 10.18 16 136486 135 50468487
Injection site pruritus 42.97 10.18 28 136474 40383 50428239
C-reactive protein abnormal 42.91 10.18 11 136491 27798 50440824
Red blood cell sedimentation rate increased 42.85 10.18 13 136489 29403 50439219
Engraftment syndrome 42.79 10.18 20 136482 316 50468306
Urinary casts 42.73 10.18 25 136477 638 50467984
Protein urine present 42.58 10.18 62 136440 5315 50463307
Blood thyroid stimulating hormone increased 42.21 10.18 66 136436 6026 50462596
Haemophagocytic lymphohistiocytosis 42.03 10.18 80 136422 8553 50460069
Sedation 42.00 10.18 15 136487 30595 50438027
Taste disorder 41.60 10.18 78 136424 8246 50460376
Blood pressure systolic increased 41.31 10.18 22 136480 35427 50433195
Rash pruritic 41.15 10.18 245 136257 47601 50421021
Drug resistance 40.48 10.18 128 136374 18861 50449761
Cystitis haemorrhagic 38.93 10.18 49 136453 3653 50464969
Pain in extremity 37.66 10.18 514 135988 272351 50196271
Urine leukocyte esterase 37.66 10.18 14 136488 119 50468503
Flushing 37.49 10.18 309 136193 66706 50401916
Nephrectomy 37.43 10.18 25 136477 810 50467812
Blood thyroid stimulating hormone decreased 37.33 10.18 51 136451 4121 50464501
Skin exfoliation 36.93 10.18 184 136318 33428 50435194
Haematocrit decreased 36.69 10.18 189 136313 34787 50433835
Arthritis 36.61 10.18 116 136386 86605 50382017
Osteoarthritis 36.35 10.18 82 136420 68524 50400098
Pleocytosis 35.79 10.18 21 136481 539 50468083
Monocyte count decreased 35.68 10.18 34 136468 1852 50466770
Therapeutic response decreased 35.60 10.18 45 136457 47186 50421436
Bacterial sepsis 35.14 10.18 46 136456 3566 50465056
Tooth disorder 35.14 10.18 144 136358 24084 50444538
Venoocclusive liver disease 35.01 10.18 50 136452 4211 50464411
Leukocyturia 34.63 10.18 26 136476 1017 50467605
Musculoskeletal pain 34.52 10.18 91 136411 72086 50396536
Dry skin 34.51 10.18 217 136285 42974 50425648
Sopor 34.49 10.18 6 136496 19873 50448749
Graft versus host disease in gastrointestinal tract 34.46 10.18 40 136462 2741 50465881
Exposure during pregnancy 34.22 10.18 189 136313 120826 50347796
Herpes virus infection 33.98 10.18 53 136449 4828 50463794
Thrombotic microangiopathy 33.94 10.18 74 136428 8717 50459905
Insomnia 33.87 10.18 661 135841 174204 50294418
Enterococcal infection 33.68 10.18 64 136438 6834 50461788
CSF protein increased 33.37 10.18 19 136483 460 50468162
Bacteraemia 33.28 10.18 100 136402 14333 50454289
CD4 lymphocytes decreased 32.96 10.18 28 136474 1311 50467311
Cells in urine 32.61 10.18 14 136488 179 50468443
Respiratory failure 32.21 10.18 382 136120 90799 50377823
Dysgeusia 32.02 10.18 197 136305 38719 50429903
Mucormycosis 31.24 10.18 36 136466 2447 50466175
Red cell distribution width decreased 31.15 10.18 25 136477 1080 50467542
Haematotoxicity 31.10 10.18 67 136435 7828 50460794
Injury 30.64 10.18 53 136449 48872 50419750
Differentiation syndrome 30.41 10.18 23 136479 910 50467712
Graft versus host disease in skin 30.40 10.18 36 136466 2520 50466102
Adenovirus infection 30.29 10.18 40 136462 3128 50465494
Microtia 30.10 10.18 16 136486 337 50468285
Injection site haemorrhage 30.08 10.18 10 136492 21336 50447286
Congenital nail disorder 30.06 10.18 11 136491 89 50468533
Varicella zoster virus infection 29.51 10.18 35 136467 2454 50466168
Primary myelofibrosis 29.49 10.18 9 136493 38 50468584
Creutzfeldt-Jakob disease 29.48 10.18 12 136490 133 50468489
Band sensation 29.35 10.18 20 136482 670 50467952
Obesity 29.24 10.18 5 136497 16770 50451852
Metastases to liver 29.07 10.18 9 136493 20095 50448527
Accidental exposure to product 28.85 10.18 13 136489 23044 50445578
Hypoaesthesia 28.82 10.18 493 136009 126764 50341858
Plasma cell leukaemia 28.69 10.18 23 136479 992 50467630
Drug withdrawal syndrome 28.59 10.18 16 136486 25065 50443557
Pulmonary thrombosis 28.57 10.18 63 136439 7478 50461144
Mean cell haemoglobin concentration increased 28.47 10.18 17 136485 451 50468171
Immune thrombocytopenia 28.33 10.18 70 136432 8947 50459675
Specific gravity urine increased 28.30 10.18 13 136489 197 50468425
Haemorrhage intracranial 27.84 10.18 85 136417 12289 50456333
Escherichia bacteraemia 27.74 10.18 38 136464 3078 50465544
Underdose 27.71 10.18 10 136492 20268 50448354
General physical health deterioration 27.71 10.18 248 136254 142186 50326436
Oxygen saturation decreased 27.52 10.18 103 136399 73145 50395477
Cataract 27.48 10.18 220 136282 47080 50421542
Engraft failure 27.43 10.18 15 136487 335 50468287
Staphylococcal bacteraemia 27.29 10.18 48 136454 4829 50463793
Lower respiratory tract infection 27.28 10.18 148 136354 95053 50373569
Antiviral drug level above therapeutic 27.08 10.18 6 136496 3 50468619
Foot deformity 27.07 10.18 9 136493 19201 50449421
Infusion site pain 27.03 10.18 84 136418 12262 50456360
Red blood cells urine 27.03 10.18 17 136485 496 50468126
Full blood count increased 26.82 10.18 21 136481 875 50467747
Device expulsion 26.74 10.18 23 136479 28799 50439823
Renal failure 26.70 10.18 420 136082 106213 50362409
Rash maculo-papular 26.59 10.18 142 136360 26499 50442123
COVID-19 26.55 10.18 216 136286 46446 50422176
Human chorionic gonadotropin increased 26.46 10.18 24 136478 1227 50467395
Skin discolouration 26.43 10.18 165 136337 32592 50436030
Red blood cell count increased 26.37 10.18 34 136468 2597 50466025
Abdominal wall infection 26.30 10.18 10 136492 91 50468531
Tri-iodothyronine free decreased 26.29 10.18 14 136488 296 50468326
Fryns syndrome 26.09 10.18 9 136493 60 50468562
Blister 26.04 10.18 130 136372 85288 50383334
Osteoporosis 25.99 10.18 51 136451 44828 50423794
Rhinitis allergic 25.99 10.18 59 136443 7141 50461481
Lactic acidosis 25.95 10.18 31 136471 33324 50435298
International normalised ratio increased 25.90 10.18 48 136454 43104 50425518
Incorrect route of product administration 25.86 10.18 9 136493 18657 50449965
Vision blurred 25.82 10.18 325 136177 78322 50390300
Abortion spontaneous 25.48 10.18 46 136456 41726 50426896
Breast cancer 25.48 10.18 48 136454 42842 50425780
Anaemia 25.22 10.18 874 135628 251582 50217040
Hepatitis fulminant 25.21 10.18 36 136466 3032 50465590
Drug dependence 24.95 10.18 11 136491 19748 50448874
Antinuclear antibody negative 24.88 10.18 12 136490 204 50468418
Mean cell volume decreased 24.84 10.18 33 136469 2596 50466026
Band neutrophil percentage increased 24.62 10.18 12 136490 209 50468413
Hordeolum 24.52 10.18 31 136471 2322 50466300
Aplastic anaemia 24.41 10.18 60 136442 7643 50460979
Acute graft versus host disease in liver 24.35 10.18 17 136485 593 50468029
Clostridium difficile infection 24.32 10.18 134 136368 25305 50443317
Dyspnoea 24.24 10.18 1219 135283 546389 49922233
Blood pressure fluctuation 24.12 10.18 37 136465 35786 50432836
Epstein-Barr virus associated lymphoproliferative disorder 23.84 10.18 26 136476 1663 50466959
Serotonin syndrome 23.82 10.18 19 136483 24694 50443928
Acute lymphocytic leukaemia recurrent 23.79 10.18 28 136474 1947 50466675
Hyperbilirubinaemia 23.69 10.18 68 136434 9502 50459120
Dilatation intrahepatic duct acquired 23.49 10.18 17 136485 628 50467994
Loss of personal independence in daily activities 23.48 10.18 103 136399 69947 50398675
Tremor 23.48 10.18 438 136064 114465 50354157
Blood brain barrier defect 23.47 10.18 9 136493 84 50468538
Metabolic acidosis 23.46 10.18 43 136459 38782 50429840
Device malfunction 23.29 10.18 6 136496 15115 50453507
Blood cholesterol increased 23.20 10.18 74 136428 55141 50413481
Systemic mycosis 23.11 10.18 21 136481 1076 50467546
Pulmonary arterial hypertension 23.11 10.18 13 136489 20306 50448316
Herpes simplex reactivation 23.06 10.18 14 136488 383 50468239
Venoocclusive disease 23.04 10.18 27 136475 1869 50466753
CSF measles antibody positive 22.74 10.18 8 136494 57 50468565
Medication error 22.71 10.18 39 136463 36065 50432557
Encephalitis autoimmune 22.52 10.18 22 136480 1236 50467386
Magnetic resonance imaging abnormal 22.49 10.18 32 136470 2686 50465936
Anti-thyroid antibody positive 22.46 10.18 14 136488 402 50468220
Coombs positive haemolytic anaemia 22.42 10.18 13 136489 326 50468296
Lymph node palpable 22.41 10.18 9 136493 96 50468526
Tri-iodothyronine free increased 22.15 10.18 11 136491 200 50468422
Renal impairment 22.07 10.18 306 136196 75355 50393267
Congenital diaphragmatic hernia 22.00 10.18 11 136491 203 50468419
Cytokine storm 21.94 10.18 12 136490 268 50468354
Rubella antibody positive 21.94 10.18 8 136494 64 50468558
Myelocyte count increased 21.93 10.18 13 136489 340 50468282
Target skin lesion 21.70 10.18 9 136493 105 50468517
Extrapyramidal disorder 21.67 10.18 3 136499 11767 50456855
Acute generalised exanthematous pustulosis 21.63 10.18 63 136439 8875 50459747
Dyslalia 21.62 10.18 14 136488 430 50468192
Urinary tract infection 21.49 10.18 772 135730 223248 50245374
Bone erosion 21.47 10.18 3 136499 11684 50456938
Staphylococcal sepsis 21.45 10.18 54 136448 6982 50461640
Pregnancy 21.44 10.18 29 136473 29548 50439074
Anaphylactic shock 21.38 10.18 14 136488 20141 50448481
Ophthalmic herpes simplex 21.30 10.18 13 136489 359 50468263
Pneumonia bacterial 21.15 10.18 55 136447 7254 50461368
Post herpetic neuralgia 21.07 10.18 26 136476 1900 50466722
Injection site mass 20.98 10.18 8 136494 15672 50452950
Eczema herpeticum 20.97 10.18 9 136493 115 50468507
Urine oxalate increased 20.94 10.18 11 136491 226 50468396
Pneumonia cytomegaloviral 20.91 10.18 26 136476 1915 50466707
Hypogammaglobulinaemia 20.90 10.18 47 136455 5652 50462970
Urobilinogen urine increased 20.89 10.18 11 136491 227 50468395
Depression 20.89 10.18 317 136185 165106 50303516
Blood bilirubin increased 20.83 10.18 153 136349 31885 50436737
Inflammation 20.75 10.18 81 136421 56831 50411791
Cytomegalovirus hepatitis 20.55 10.18 12 136490 305 50468317
Surgery 20.53 10.18 31 136471 30174 50438448
Ear swelling 20.51 10.18 20 136482 1121 50467501
Tonsillar haemorrhage 20.51 10.18 11 136491 236 50468386
Corneal lesion 20.33 10.18 6 136496 22 50468600
Graft versus host disease in liver 20.26 10.18 14 136488 480 50468142
Blood pressure diastolic decreased 20.17 10.18 10 136492 16771 50451851
Fall 20.16 10.18 720 135782 334212 50134410
Klebsiella test positive 19.97 10.18 18 136484 913 50467709
Focal myositis 19.92 10.18 6 136496 24 50468598
Gastrointestinal haemorrhage 19.91 10.18 116 136386 73205 50395417
Multiple sclerosis relapse 19.84 10.18 190 136312 42774 50425848
Pulmonary fibrosis 19.78 10.18 22 136480 24415 50444207
Pneumonia influenzal 19.70 10.18 22 136480 1445 50467177
Premature delivery 19.49 10.18 21 136481 23642 50444980
Joint range of motion decreased 19.44 10.18 13 136489 18499 50450123
Band neutrophil count increased 19.42 10.18 12 136490 339 50468283
Thyroxine free decreased 19.42 10.18 14 136488 514 50468108
Body temperature decreased 19.36 10.18 10 136492 16385 50452237
Monoclonal immunoglobulin present 19.30 10.18 16 136486 724 50467898
Agranulocytosis 19.26 10.18 111 136391 21310 50447312
Blood thyroid stimulating hormone abnormal 19.21 10.18 16 136486 729 50467893
Herpes simplex pneumonia 19.13 10.18 5 136497 10 50468612
Brain oedema 19.12 10.18 75 136427 12295 50456327
Myelocyte percentage increased 19.10 10.18 10 136492 204 50468418
Diabetes mellitus 19.04 10.18 68 136434 48965 50419657
Systemic candida 19.01 10.18 30 136472 2760 50465862
Feeling hot 18.92 10.18 175 136327 39027 50429595
Diffuse large B-cell lymphoma 18.90 10.18 45 136457 5617 50463005
Atrial fibrillation 18.80 10.18 382 136120 101363 50367259
Haemorrhagic disorder 18.80 10.18 16 136486 751 50467871
Extravasation 18.71 10.18 25 136477 1977 50466645
Jarisch-Herxheimer reaction 18.69 10.18 11 136491 284 50468338
Pulmonary mucormycosis 18.59 10.18 10 136492 216 50468406
Thyroid stimulating immunoglobulin 18.58 10.18 7 136495 62 50468560
Metastases to bone 18.42 10.18 13 136489 17982 50450640
Eosinophil count increased 18.34 10.18 59 136443 8771 50459851
pH urine increased 18.32 10.18 12 136490 376 50468246
Right ventricular failure 18.32 10.18 10 136492 15883 50452739
Hospitalisation 18.17 10.18 108 136394 67829 50400793
Herpes simplex encephalitis 18.12 10.18 11 136491 301 50468321
Immune system disorder 18.07 10.18 56 136446 8161 50460461
Creatinine urine decreased 18.00 10.18 9 136493 166 50468456
Autoimmune thyroiditis 17.95 10.18 32 136470 3253 50465369
Craniofacial deformity 17.86 10.18 8 136494 114 50468508
Obstructive airways disorder 17.82 10.18 10 136492 15642 50452980
Abdominal wall wound 17.66 10.18 7 136495 72 50468550
Electrocardiogram QT prolonged 17.57 10.18 76 136426 51810 50416812
Antineutrophil cytoplasmic antibody positive 17.55 10.18 13 136489 498 50468124
Monocyte count increased 17.40 10.18 43 136459 5496 50463126
Infusion site scar 17.37 10.18 11 136491 325 50468297
Myeloblast percentage decreased 17.27 10.18 6 136496 41 50468581
Product dose omission issue 17.24 10.18 632 135870 183206 50285416
Hypoglossal nerve paralysis 17.23 10.18 5 136497 17 50468605
Tendonitis 17.19 10.18 12 136490 16693 50451929
Chronic lymphocytic leukaemia 17.18 10.18 26 136476 2307 50466315
Thyroid stimulating immunoglobulin increased 17.16 10.18 7 136495 78 50468544
Weight increased 17.15 10.18 414 136088 201477 50267145
Mean cell haemoglobin concentration decreased 17.13 10.18 29 136473 2830 50465792
Joint stiffness 17.07 10.18 35 136467 30273 50438349
Injection site warmth 17.07 10.18 8 136494 13858 50454764
Bradycardia 16.98 10.18 256 136246 64170 50404452
Infusion site discomfort 16.94 10.18 16 136486 862 50467760
Pseudomonas infection 16.93 10.18 60 136442 9370 50459252
Lipaemic index score 16.93 10.18 7 136495 81 50468541
Premature labour 16.84 10.18 5 136497 11471 50457151
Mantle cell lymphoma 16.80 10.18 12 136490 434 50468188
Small intestine adenocarcinoma 16.80 10.18 5 136497 19 50468603
Injection site urticaria 16.74 10.18 6 136496 12211 50456411
Lactose intolerance 16.64 10.18 27 136475 2543 50466079
Acute disseminated encephalomyelitis 16.62 10.18 9 136493 197 50468425
Ulcer 16.56 10.18 18 136484 20182 50448440
No adverse event 16.31 10.18 42 136460 33536 50435086
Pulmonary hypoplasia 16.26 10.18 10 136492 280 50468342
Product quality issue 16.25 10.18 37 136465 30821 50437801
Lupus-like syndrome 16.17 10.18 3 136499 9488 50459134
Glomerulonephritis chronic 16.13 10.18 8 136494 145 50468477
Dystonia 16.10 10.18 6 136496 11920 50456702
Meningitis aseptic 16.08 10.18 35 136467 4117 50464505
Toxic neuropathy 16.08 10.18 11 136491 371 50468251
Sepsis syndrome 16.04 10.18 15 136487 798 50467824
Delayed engraftment 16.00 10.18 7 136495 94 50468528
Eye swelling 15.96 10.18 101 136401 20043 50448579
Metastases to lung 15.82 10.18 5 136497 11015 50457607
Gastritis fungal 15.80 10.18 7 136495 97 50468525
Neutrophil count increased 15.80 10.18 78 136424 14117 50454505
Leukopenia 15.78 10.18 263 136239 67265 50401357
Pulmonary embolism 15.66 10.18 372 136130 101332 50367290
Thunderclap headache 15.60 10.18 8 136494 156 50468466
Spinal fracture 15.54 10.18 83 136419 15490 50453132
Ejection fraction abnormal 15.51 10.18 15 136487 832 50467790
Chest pain 15.49 10.18 361 136141 176521 50292101
CSF test abnormal 15.48 10.18 10 136492 306 50468316
Body height decreased 15.42 10.18 56 136446 8852 50459770
Amyloidosis 15.41 10.18 16 136486 967 50467655
Therapy interrupted 15.39 10.18 19 136483 20133 50448489
Coronary artery disease 15.36 10.18 36 136466 29690 50438932
Cardio-respiratory arrest 15.31 10.18 84 136418 53808 50414814
Leukaemia 15.31 10.18 31 136471 3468 50465154
Rash papular 15.29 10.18 71 136431 12533 50456089
Capillary leak syndrome 15.27 10.18 22 136480 1868 50466754
Gait disturbance 15.21 10.18 299 136203 149706 50318916
Treatment noncompliance 15.19 10.18 37 136465 30113 50438509
Posterior reversible encephalopathy syndrome 15.19 10.18 80 136422 14848 50453774
Blood pressure increased 15.18 10.18 260 136242 132872 50335750
Caesarean section 15.10 10.18 12 136490 15627 50452995
Escherichia infection 15.06 10.18 64 136438 10877 50457745
Blastomycosis 15.03 10.18 9 136493 240 50468382
Blood creatinine decreased 14.97 10.18 38 136464 4938 50463684
Angina pectoris 14.95 10.18 30 136472 26158 50442464
Injection site rash 14.90 10.18 13 136489 16164 50452458
Basophil percentage decreased 14.76 10.18 3 136499 0 50468622
Bone marrow transplant 14.73 10.18 13 136489 641 50467981
Refractoriness to platelet transfusion 14.67 10.18 5 136497 32 50468590
Lung infiltration 14.48 10.18 73 136429 13320 50455302
Toxic encephalopathy 14.44 10.18 40 136462 5475 50463147
Death 14.43 10.18 1041 135461 324338 50144284
Chills 14.39 10.18 352 136150 96335 50372287
Organic brain syndrome 14.38 10.18 8 136494 185 50468437
Hyperuricaemia 14.35 10.18 36 136466 4644 50463978
Tumour flare 14.30 10.18 9 136493 263 50468359
Sinus disorder 14.28 10.18 92 136410 18366 50450256
Pneumonia parainfluenzae viral 14.24 10.18 6 136496 73 50468549
Listeriosis 14.22 10.18 18 136484 1350 50467272
Eosinophil percentage decreased 14.15 10.18 8 136494 191 50468431
Pneumonia aspiration 14.14 10.18 40 136462 30964 50437658
Geotrichum infection 14.04 10.18 11 136491 459 50468163
Hepatic cirrhosis 14.04 10.18 16 136486 17561 50451061
Avulsion fracture 14.00 10.18 9 136493 273 50468349
Monocyte percentage decreased 13.97 10.18 8 136494 196 50468426
Bilirubin urine present 13.95 10.18 6 136496 77 50468545
Malignant sweat gland neoplasm 13.92 10.18 4 136498 13 50468609
Basophil count increased 13.87 10.18 14 136488 818 50467804
Cardiac disorder 13.84 10.18 177 136325 42802 50425820
Bursitis 13.84 10.18 24 136478 22111 50446511
Dehydration 13.78 10.18 522 135980 151927 50316695
Bacterial infection 13.76 10.18 83 136419 16198 50452424
Meningitis 13.73 10.18 42 136460 6079 50462543
Gastrointestinal disorder 13.70 10.18 176 136326 94280 50374342
Model for end stage liver disease score increased 13.69 10.18 4 136498 14 50468608
Culture stool positive 13.68 10.18 9 136493 284 50468338
Herpes zoster meningoencephalitis 13.66 10.18 9 136493 285 50468337
Peripheral sensory neuropathy 13.65 10.18 44 136458 6547 50462075
Meningitis listeria 13.63 10.18 11 136491 479 50468143
Disseminated intravascular coagulation 13.63 10.18 86 136416 17049 50451573
Lung neoplasm malignant 13.60 10.18 13 136489 15471 50453151
Fumbling 13.54 10.18 7 136495 139 50468483
Duodenal stenosis 13.51 10.18 11 136491 485 50468137
Pseudomonal sepsis 13.46 10.18 22 136480 2085 50466537
Blast cell count increased 13.44 10.18 10 136492 386 50468236
Arteritis infective 13.30 10.18 5 136497 44 50468578
Chronic obstructive pulmonary disease 13.23 10.18 87 136415 53348 50415274
Housebound 13.21 10.18 8 136494 218 50468404
Muscle rigidity 13.17 10.18 5 136497 9824 50458798
Device issue 13.09 10.18 21 136481 19951 50448671
Increased tendency to bruise 13.09 10.18 55 136447 9301 50459321
Viral skin infection 13.09 10.18 4 136498 17 50468605
Angioimmunoblastic T-cell lymphoma 13.06 10.18 6 136496 91 50468531
Pneumococcal sepsis 12.98 10.18 11 136491 513 50468109
Blood loss anaemia 12.98 10.18 3 136499 8136 50460486
Human herpesvirus 6 encephalitis 12.98 10.18 7 136495 152 50468470
Toxic epidermal necrolysis 12.94 10.18 99 136403 20893 50447729
Oesophageal atresia 12.93 10.18 11 136491 516 50468106
Procedural pain 12.88 10.18 11 136491 13821 50454801
Renal tubular necrosis 12.87 10.18 58 136444 10110 50458512
Tracheo-oesophageal fistula 12.80 10.18 11 136491 523 50468099
Pneumonia pseudomonal 12.76 10.18 21 136481 2002 50466620
Congenital syphilis 12.68 10.18 3 136499 3 50468619
Swelling of eyelid 12.68 10.18 20 136482 1840 50466782
Gastroenteritis salmonella 12.66 10.18 11 136491 531 50468091
Migraine 12.56 10.18 136 136366 75144 50393478
Device breakage 12.56 10.18 5 136497 9542 50459080
Periorbital swelling 12.54 10.18 20 136482 1857 50466765
Adenoviral hepatitis 12.52 10.18 8 136494 240 50468382
Joint dislocation 12.50 10.18 9 136493 12324 50456298
Rash macular 12.50 10.18 92 136410 19185 50449437
Monoclonal immunoglobulin increased 12.50 10.18 6 136496 101 50468521
Diabetic ketoacidosis 12.48 10.18 18 136484 17854 50450768
Staphylococcal infection 12.47 10.18 149 136353 35467 50433155
Acute lymphocytic leukaemia 12.47 10.18 22 136480 2219 50466403
Interstitial lung disease 12.46 10.18 88 136414 53088 50415534
Joint injury 12.41 10.18 25 136477 21764 50446858
Haemodialysis 12.36 10.18 50 136452 8312 50460310
Oesophageal irritation 12.34 10.18 6 136496 104 50468518
White blood cells urine 12.33 10.18 9 136493 337 50468285
Dust allergy 12.32 10.18 11 136491 551 50468071
Hiatus hernia 12.30 10.18 19 136483 18325 50450297
COVID-19 pneumonia 12.25 10.18 50 136452 8345 50460277
White blood cell disorder 12.24 10.18 21 136481 2071 50466551
Genital rash 12.21 10.18 10 136492 445 50468177
Gastroenteritis norovirus 12.20 10.18 19 136483 1728 50466894
Ingrowing nail 12.11 10.18 20 136482 1912 50466710
Factor XIII Inhibition 12.10 10.18 4 136498 23 50468599
Blood creatine phosphokinase increased 12.03 10.18 34 136468 26333 50442289
Depressed mood 12.03 10.18 49 136453 33974 50434648
Klebsiella bacteraemia 12.02 10.18 16 136486 1261 50467361
Live birth 11.98 10.18 16 136486 16392 50452230
Blood pressure systolic abnormal 11.98 10.18 3 136499 7703 50460919
Immunosuppressant drug level increased 11.96 10.18 26 136476 3056 50465566
Panniculitis 11.95 10.18 4 136498 8499 50460123
Chronic hepatitis B 11.85 10.18 7 136495 182 50468440
Ear pruritus 11.80 10.18 23 136479 2503 50466119
Cytomegalovirus gastroenteritis 11.78 10.18 7 136495 184 50468438
Campylobacter gastroenteritis 11.73 10.18 9 136493 364 50468258
Injection site induration 11.72 10.18 4 136498 8393 50460229
Salmonella test positive 11.68 10.18 4 136498 26 50468596
Diabetes mellitus inadequate control 11.59 10.18 11 136491 13134 50455488
Retinal depigmentation 11.59 10.18 8 136494 274 50468348
Asthenia 11.57 10.18 1005 135497 318037 50150585
CSF oligoclonal band present 11.57 10.18 6 136496 120 50468502
Injection site phlebitis 11.52 10.18 6 136496 121 50468501
Mycobacterium kansasii infection 11.48 10.18 6 136496 122 50468500
Acute HIV infection 11.48 10.18 3 136499 6 50468616
Viral oesophagitis 11.48 10.18 3 136499 6 50468616
Phyllodes tumour 11.43 10.18 4 136498 28 50468594
Anti-thyroid antibody 11.43 10.18 4 136498 28 50468594
Bone pain 11.42 10.18 185 136317 47044 50421578
Femur fracture 11.42 10.18 57 136445 37407 50431215
Respiratory arrest 11.40 10.18 42 136460 29967 50438655
Varicella virus test positive 11.39 10.18 6 136496 124 50468498
Obliterative bronchiolitis 11.37 10.18 19 136483 1834 50466788
Cardiac arrest 11.35 10.18 158 136344 83493 50385129
Antiphospholipid syndrome 11.30 10.18 17 136485 1500 50467122
Staphylococcus test positive 11.30 10.18 27 136475 3379 50465243
Blood calcium increased 11.29 10.18 46 136456 7673 50460949
Neuralgia 11.27 10.18 99 136403 21764 50446858
Therapy non-responder 11.20 10.18 86 136416 50936 50417686
Prescribed underdose 11.20 10.18 16 136486 15933 50452689
Herpes ophthalmic 11.16 10.18 14 136488 1040 50467582
Non-Hodgkin's lymphoma recurrent 11.16 10.18 3 136499 7 50468615
Varicella 11.09 10.18 18 136484 1696 50466926
Cerebral artery stenosis 11.09 10.18 9 136493 395 50468227
Malignant neoplasm progression 11.00 10.18 124 136378 68000 50400622
Refractory anaemia with an excess of blasts 10.99 10.18 9 136493 400 50468222
Pneumonia respiratory syncytial viral 10.95 10.18 11 136491 639 50467983
Alanine aminotransferase increased 10.93 10.18 314 136188 88045 50380577
Prescribed overdose 10.91 10.18 14 136488 14586 50454036
Immature granulocyte percentage increased 10.88 10.18 3 136499 8 50468614
Blood lactate dehydrogenase increased 10.83 10.18 90 136412 19472 50449150
Enthesopathy 10.80 10.18 3 136499 7190 50461432
Wheezing 10.80 10.18 111 136391 61936 50406686
Protein total increased 10.78 10.18 22 136480 2474 50466148
Oral herpes 10.76 10.18 94 136408 20631 50447991
Post procedural complication 10.76 10.18 15 136487 15089 50453533
Vulvovaginal injury 10.75 10.18 9 136493 413 50468209
Tendon rupture 10.69 10.18 3 136499 7141 50461481
Myositis 10.66 10.18 4 136498 7916 50460706
Weight decreased 10.62 10.18 488 136014 220757 50247865
Pancreatitis viral 10.62 10.18 3 136499 9 50468613
Melaena 10.60 10.18 37 136465 26827 50441795
Transplant failure 10.59 10.18 16 136486 1417 50467205
Coagulation test abnormal 10.59 10.18 11 136491 665 50467957
Liver injury 10.59 10.18 33 136469 24773 50443849
Hypoaesthesia oral 10.58 10.18 57 136445 10671 50457951
Large intestine infection 10.58 10.18 17 136485 1589 50467033
Partial seizures 10.56 10.18 33 136469 4832 50463790
Myalgia 10.52 10.18 255 136247 124064 50344558
Nystagmus 10.52 10.18 36 136466 5525 50463097
Premature baby 10.48 10.18 21 136481 18316 50450306
Transfusion reaction 10.47 10.18 13 136489 956 50467666
Hepatitis B antibody positive 10.46 10.18 4 136498 37 50468585
Tri-iodothyronine free abnormal 10.46 10.18 4 136498 37 50468585
Back pain 10.44 10.18 708 135794 219322 50249300
Incorrect dose administered 10.44 10.18 82 136420 48332 50420290
Streptococcal bacteraemia 10.39 10.18 16 136486 1442 50467180
Viral haemorrhagic cystitis 10.37 10.18 11 136491 682 50467940
Mental status changes 10.29 10.18 146 136356 36126 50432496
Vibration test abnormal 10.28 10.18 4 136498 39 50468583
Idiopathic pneumonia syndrome 10.25 10.18 8 136494 332 50468290
Squamous cell carcinoma of skin 10.22 10.18 34 136468 5144 50463478

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Plasma cell myeloma 1227.57 10.52 1099 120437 36016 29416975
Neuropathy peripheral 462.40 10.52 948 120588 70079 29382912
White blood cell count decreased 455.03 10.52 1036 120500 82326 29370665
Febrile neutropenia 442.10 10.52 1232 120304 111008 29341983
Pneumonia 438.12 10.52 2518 119018 317654 29135337
Platelet count decreased 383.91 10.52 1120 120416 103552 29349439
Drug abuse 307.08 10.52 4 121532 79879 29373112
Full blood count decreased 298.10 10.52 348 121188 15644 29437347
Completed suicide 284.42 10.52 23 121513 90223 29362768
Thrombosis 266.31 10.52 563 120973 42482 29410509
Neutropenia 261.73 10.52 1153 120383 130558 29322433
Cytokine release syndrome 260.54 10.52 295 121241 12824 29440167
Pyrexia 258.40 10.52 2040 119496 285582 29167409
Neurotoxicity 250.96 10.52 305 121231 14308 29438683
Toxicity to various agents 233.42 10.52 222 121314 173439 29279552
Rash 212.40 10.52 1420 120116 188399 29264592
Neutrophil count decreased 202.32 10.52 509 121027 43058 29409933
Adverse drug reaction 198.36 10.52 355 121181 23665 29429326
Drug interaction 187.13 10.52 328 121208 197057 29255934
Graft versus host disease 186.92 10.52 214 121322 9414 29443577
Laboratory test abnormal 166.08 10.52 281 121255 17904 29435087
Fatigue 159.07 10.52 1992 119544 314829 29138162
Cytomegalovirus infection 158.06 10.52 316 121220 22899 29430092
Pancytopenia 125.25 10.52 673 120863 82495 29370496
Thrombocytopenia 115.86 10.52 948 120588 133875 29319116
Intentional product misuse 114.42 10.52 7 121529 34654 29418337
Acute graft versus host disease 113.97 10.52 130 121406 5694 29447297
Acute graft versus host disease in skin 110.26 10.52 115 121421 4549 29448442
Intentional overdose 105.74 10.52 16 121520 38512 29414479
Overdose 100.23 10.52 108 121428 79711 29373280
Influenza 99.70 10.52 388 121148 41493 29411498
Deep vein thrombosis 92.91 10.52 474 121062 56925 29396066
Tooth disorder 92.01 10.52 151 121385 9378 29443613
Sepsis 91.94 10.52 943 120593 141739 29311252
Meningoencephalitis herpetic 91.24 10.52 50 121486 719 29452272
Diarrhoea 90.99 10.52 1892 119644 330806 29122185
Cytomegalovirus viraemia 89.67 10.52 120 121416 6200 29446791
Hypoglycaemia 85.47 10.52 46 121490 48300 29404691
Rheumatoid arthritis 84.55 10.52 15 121521 32137 29420854
Bronchopulmonary aspergillosis 83.96 10.52 168 121368 12176 29440815
Plasma cell myeloma recurrent 83.83 10.52 89 121447 3594 29449397
Suicide attempt 83.26 10.52 19 121517 34091 29418900
Cystitis haemorrhagic 79.77 10.52 99 121437 4743 29448248
Constipation 79.06 10.52 766 120770 113394 29339597
Chronic lymphocytic leukaemia 76.06 10.52 84 121452 3549 29449442
International normalised ratio increased 75.87 10.52 44 121492 44328 29408663
Acute graft versus host disease in intestine 74.62 10.52 68 121468 2273 29450718
Myocardial infarction 74.46 10.52 220 121316 110076 29342915
Muscle spasms 70.73 10.52 484 121052 64598 29388393
Encephalitis 70.50 10.52 108 121428 6322 29446669
Injection site pain 69.97 10.52 23 121513 32423 29420568
Herpes simplex 69.60 10.52 93 121443 4797 29448194
Infection 68.15 10.52 544 120992 76207 29376784
Suicidal ideation 67.52 10.52 29 121507 34687 29418304
Acute myeloid leukaemia recurrent 67.35 10.52 57 121479 1723 29451268
Inappropriate schedule of product administration 66.74 10.52 51 121485 44421 29408570
Wrong technique in product usage process 66.51 10.52 23 121513 31405 29421586
Drug dependence 64.26 10.52 6 121530 20975 29432016
Chronic graft versus host disease 64.17 10.52 81 121455 3948 29449043
Psoriasis 62.55 10.52 27 121509 32200 29420791
Immune effector cell-associated neurotoxicity syndrome 62.23 10.52 51 121485 1473 29451518
Drug ineffective 62.20 10.52 1085 120451 362085 29090906
Rhabdomyolysis 61.19 10.52 97 121439 60711 29392280
Lymphocyte count decreased 60.87 10.52 196 121340 19075 29433916
Herpes zoster 60.15 10.52 264 121272 29788 29423203
Encephalitis viral 59.52 10.52 44 121492 1088 29451903
Mucosal inflammation 59.07 10.52 272 121264 31323 29421668
Light chain analysis increased 58.35 10.52 43 121493 1058 29451933
Tumour lysis syndrome 57.00 10.52 155 121381 13729 29439262
Bradycardia 56.78 10.52 115 121421 65514 29387477
Toxic encephalopathy 55.62 10.52 81 121455 4531 29448460
Cardio-respiratory arrest 55.52 10.52 76 121460 50525 29402466
Adenovirus infection 54.94 10.52 79 121457 4368 29448623
Arthralgia 54.51 10.52 343 121193 139274 29313717
Hyperkalaemia 54.46 10.52 106 121430 61286 29391705
Body height decreased 54.38 10.52 69 121467 3381 29449610
Dyspnoea 54.34 10.52 981 120555 325751 29127240
Ageusia 54.15 10.52 116 121420 8822 29444169
Acute myeloid leukaemia 54.02 10.52 170 121366 16343 29436648
Acute myocardial infarction 51.90 10.52 74 121462 48364 29404627
Plasmacytoma 51.79 10.52 65 121471 3150 29449841
Haematotoxicity 50.22 10.52 95 121441 6604 29446387
Pneumonia fungal 49.75 10.52 87 121449 5690 29447301
Gastrointestinal haemorrhage 48.48 10.52 166 121370 79367 29373624
Drug resistance 48.37 10.52 196 121340 21344 29431647
Off label use 48.15 10.52 909 120627 299891 29153100
Taste disorder 47.89 10.52 77 121459 4699 29448292
Pathogen resistance 47.65 10.52 104 121432 8012 29444979
Necrotising retinitis 47.62 10.52 33 121503 735 29452256
Contraindicated product administered 46.99 10.52 9 121527 18257 29434734
Cardiac arrest 46.71 10.52 187 121349 85404 29367587
Renal disorder 46.36 10.52 200 121336 22395 29430596
Anxiety 46.27 10.52 187 121349 85178 29367813
Seasonal allergy 45.46 10.52 78 121458 5024 29447967
Red blood cell count decreased 44.63 10.52 216 121320 25386 29427605
Septic shock 43.84 10.52 421 121115 62139 29390852
Respiratory depression 43.83 10.52 3 121533 13520 29439471
Angioedema 43.69 10.52 40 121496 31875 29421116
Parainfluenzae virus infection 43.66 10.52 50 121486 2199 29450792
COVID-19 42.83 10.52 274 121262 35740 29417251
Interstitial lung disease 42.74 10.52 110 121426 57608 29395383
Condition aggravated 42.60 10.52 390 121146 145905 29307086
Blood pressure increased 42.35 10.52 158 121378 73645 29379346
Respiratory arrest 42.22 10.52 27 121509 25806 29427185
Therapeutic product effect incomplete 42.15 10.52 60 121476 39245 29413746
Nephropathy toxic 42.09 10.52 118 121418 10638 29442353
Thrombotic microangiopathy 41.90 10.52 103 121433 8578 29444413
Pulmonary thrombosis 41.86 10.52 87 121449 6478 29446513
Post transplant lymphoproliferative disorder 41.30 10.52 78 121458 5415 29447576
Unevaluable event 40.49 10.52 235 121301 29616 29423375
Neutropenic sepsis 40.47 10.52 123 121413 11604 29441387
Cytomegalovirus infection reactivation 40.45 10.52 59 121477 3305 29449686
Aggression 40.39 10.52 52 121484 35489 29417502
Depression 39.84 10.52 197 121339 84950 29368041
Full blood count increased 39.82 10.52 30 121506 764 29452227
Cytomegalovirus test positive 39.67 10.52 59 121477 3364 29449627
Organic brain syndrome 39.59 10.52 20 121516 241 29452750
Ophthalmic herpes simplex 39.23 10.52 20 121516 246 29452745
Electrocardiogram QT prolonged 38.91 10.52 55 121481 36082 29416909
Blood creatine phosphokinase increased 38.87 10.52 67 121469 40577 29412414
Pneumonia cytomegaloviral 38.16 10.52 51 121485 2631 29450360
Crystal urine present 37.84 10.52 23 121513 406 29452585
Coronary artery disease 37.73 10.52 78 121458 44112 29408879
Venoocclusive liver disease 37.65 10.52 86 121450 6831 29446160
Intentional self-injury 37.02 10.52 4 121532 12457 29440534
Drug withdrawal syndrome 36.63 10.52 14 121522 17970 29435021
Cytopenia 36.48 10.52 106 121430 9753 29443238
Sedation 36.37 10.52 13 121523 17392 29435599
Multiple allergies 36.28 10.52 44 121492 2058 29450933
Labelled drug-drug interaction medication error 35.88 10.52 4 121532 12155 29440836
Cardiogenic shock 35.79 10.52 17 121519 19173 29433818
Epstein-Barr virus infection 35.62 10.52 82 121454 6547 29446444
Blood pressure fluctuation 35.04 10.52 19 121517 19875 29433116
Foetal exposure during pregnancy 35.04 10.52 53 121483 33814 29419177
Blood bilirubin increased 34.99 10.52 249 121287 33644 29419347
Rash pruritic 34.98 10.52 183 121353 22180 29430811
Stem cell transplant 34.96 10.52 42 121494 1945 29451046
Spinal fracture 34.59 10.52 80 121456 6406 29446585
Hospitalisation 34.54 10.52 87 121449 45901 29407090
Protein total increased 34.40 10.52 43 121493 2075 29450916
Psoriatic arthropathy 34.25 10.52 9 121527 14682 29438309
Mantle cell lymphoma 34.05 10.52 32 121504 1113 29451878
Fusarium infection 33.83 10.52 30 121506 967 29452024
Human herpesvirus 6 infection 33.80 10.52 40 121496 1823 29451168
Fungal infection 33.53 10.52 128 121408 13557 29439434
Acute graft versus host disease in liver 33.45 10.52 34 121502 1304 29451687
Somnolence 33.04 10.52 238 121298 93717 29359274
Lymphocyte percentage decreased 32.84 10.52 41 121495 1976 29451015
Full blood count abnormal 32.43 10.52 135 121401 14878 29438113
Rectal haemorrhage 32.08 10.52 58 121478 34491 29418500
Urine abnormality 31.78 10.52 37 121499 1657 29451334
Metabolic acidosis 31.71 10.52 67 121469 37595 29415396
Toxoplasmosis 31.65 10.52 31 121505 1136 29451855
Loss of consciousness 31.47 10.52 177 121359 73879 29379112
Herpes virus infection 31.32 10.52 45 121491 2486 29450505
Blood pressure systolic increased 31.30 10.52 15 121521 16830 29436161
Asthma 31.28 10.52 57 121479 33792 29419199
Treatment noncompliance 31.26 10.52 32 121504 24195 29428796
Diffuse large B-cell lymphoma 30.86 10.52 75 121461 6201 29446790
Engraft failure 30.86 10.52 20 121516 397 29452594
Abdominal pain 30.82 10.52 382 121154 134975 29318016
Bacterial infection 30.82 10.52 120 121416 12828 29440163
Intentional product use issue 30.69 10.52 82 121454 42416 29410575
Lactic acidosis 30.65 10.52 48 121488 30199 29422792
Graft versus host disease in skin 30.55 10.52 52 121484 3327 29449664
Drug hypersensitivity 30.44 10.52 161 121375 68245 29384746
Melaena 30.17 10.52 51 121485 31125 29421866
Aspartate aminotransferase 30.13 10.52 12 121524 78 29452913
Clostridium difficile infection 29.45 10.52 138 121398 16003 29436988
Cardiac failure congestive 29.40 10.52 189 121347 76392 29376599
Haematochezia 29.32 10.52 68 121468 36915 29416076
Encephalopathy 29.15 10.52 223 121313 30820 29422171
Neuroleptic malignant syndrome 29.07 10.52 15 121521 16133 29436858
Malignant neoplasm progression 29.02 10.52 181 121355 73678 29379313
Pain in extremity 28.92 10.52 302 121234 110131 29342860
Neutrophil percentage increased 28.67 10.52 36 121500 1745 29451246
Chest pain 28.60 10.52 308 121228 111665 29341326
Immune system disorder 28.45 10.52 58 121478 4259 29448732
Venoocclusive disease 28.33 10.52 43 121493 2496 29450495
General physical health deterioration 28.29 10.52 278 121258 102579 29350412
Hyperbilirubinaemia 28.22 10.52 129 121407 14805 29438186
Vomiting 28.13 10.52 661 120875 211599 29241392
Peripheral swelling 28.05 10.52 392 121144 63347 29389644
Engraftment syndrome 27.88 10.52 25 121511 818 29452173
Enterococcal infection 27.85 10.52 86 121450 8182 29444809
Acute lymphocytic leukaemia recurrent 27.22 10.52 42 121494 2474 29450517
Pneumonia viral 26.89 10.52 43 121493 2612 29450379
Mucormycosis 26.83 10.52 63 121473 5095 29447896
Monoclonal immunoglobulin present 26.55 10.52 25 121511 872 29452119
Urine analysis abnormal 26.50 10.52 35 121501 1785 29451206
Wheezing 26.45 10.52 61 121475 33179 29419812
Atrial fibrillation 26.15 10.52 593 120943 105053 29347938
Treatment failure 26.12 10.52 72 121464 36867 29416124
Stress 25.94 10.52 30 121506 21460 29431531
Injury 25.91 10.52 24 121512 19022 29433969
Colitis ulcerative 25.90 10.52 10 121526 12759 29440232
Multiple organ dysfunction syndrome 25.72 10.52 383 121153 62733 29390258
Arteriosclerosis coronary artery 25.69 10.52 6 121530 10599 29442392
Pre-engraftment immune reaction 25.68 10.52 11 121525 88 29452903
Glycosylated haemoglobin increased 25.66 10.52 4 121532 9422 29443569
Oxygen saturation decreased 25.25 10.52 97 121439 44840 29408151
Hepatic cirrhosis 25.14 10.52 14 121522 14430 29438561
Therapeutic product effect decreased 25.12 10.52 52 121484 29399 29423592
Anaphylactic reaction 24.97 10.52 47 121489 27526 29425465
COVID-19 pneumonia 24.94 10.52 91 121445 9431 29443560
Emotional distress 24.87 10.52 13 121523 13882 29439109
Synovitis 24.77 10.52 7 121529 10883 29442108
Device malfunction 24.60 10.52 3 121533 8504 29444487
Crystalluria 23.80 10.52 17 121519 398 29452593
Tooth deposit 23.78 10.52 10 121526 76 29452915
Bacteraemia 23.78 10.52 131 121405 16192 29436799
Hiccups 23.52 10.52 85 121451 8768 29444223
Chest discomfort 23.49 10.52 103 121433 45880 29407111
Squamous cell carcinoma of skin 23.46 10.52 89 121447 9397 29443594
Metastases to bone 23.20 10.52 6 121530 9892 29443099
Oroantral fistula 23.12 10.52 13 121523 197 29452794
Obesity 23.08 10.52 6 121530 9857 29443134
Angina pectoris 23.06 10.52 50 121486 27800 29425191
Sleep apnoea syndrome 22.98 10.52 23 121513 17576 29435415
Polyomavirus viraemia 22.96 10.52 20 121516 629 29452362
Underdose 22.94 10.52 10 121526 11859 29441132
Coma 22.91 10.52 84 121452 39366 29413625
Product quality issue 22.87 10.52 19 121517 15876 29437115
Lower respiratory tract infection fungal 22.86 10.52 19 121517 560 29452431
Strongyloidiasis 22.81 10.52 37 121499 2275 29450716
Clostridium difficile colitis 22.69 10.52 111 121425 13101 29439890
Mobility decreased 22.43 10.52 45 121491 25735 29427256
Blood test abnormal 22.42 10.52 63 121473 5686 29447305
Pseudomonal sepsis 22.40 10.52 42 121494 2900 29450091
Herpes ophthalmic 22.33 10.52 17 121519 440 29452551
Body temperature decreased 22.22 10.52 8 121528 10656 29442335
Cellulitis enterococcal 22.15 10.52 9 121527 62 29452929
Streptococcal bacteraemia 22.03 10.52 31 121505 1680 29451311
Urine leukocyte esterase positive 21.88 10.52 16 121520 389 29452602
Graft versus host disease in gastrointestinal tract 21.74 10.52 44 121492 3214 29449777
Myalgia 21.65 10.52 197 121339 73822 29379169
Specific gravity urine increased 21.53 10.52 11 121525 136 29452855
Anti-platelet antibody positive 21.51 10.52 13 121523 227 29452764
Paranoia 21.29 10.52 7 121529 9870 29443121
Fibrous histiocytoma 21.25 10.52 10 121526 102 29452889
Herpes zoster meningitis 21.17 10.52 7 121529 24 29452967
Neutrophil Pelger-Huet anomaly present 21.12 10.52 13 121523 235 29452756
Product dose omission issue 21.11 10.52 532 121004 95851 29357140
Incorrect route of product administration 21.03 10.52 9 121527 10792 29442199
Varicella zoster virus infection 21.02 10.52 28 121508 1440 29451551
Cyanosis 20.98 10.52 10 121526 11257 29441734
Dystonia 20.86 10.52 7 121529 9742 29443249
Lactose intolerance 20.84 10.52 25 121511 1156 29451835
Haemophagocytic lymphohistiocytosis 20.80 10.52 92 121444 10412 29442579
Diabetes mellitus inadequate control 20.78 10.52 12 121524 12122 29440869
Product use issue 20.75 10.52 125 121411 51319 29401672
Pneumonia respiratory syncytial viral 20.71 10.52 21 121515 803 29452188
Monocyte percentage increased 20.67 10.52 22 121514 891 29452100
Respiratory syncytial virus infection 20.48 10.52 46 121490 3613 29449378
Neutropenic infection 20.38 10.52 26 121510 1281 29451710
Dry eye 20.20 10.52 71 121465 7225 29445766
Candida infection 20.08 10.52 119 121417 15106 29437885
Enterococcal bacteraemia 20.07 10.52 28 121508 1505 29451486
Fear 20.03 10.52 7 121529 9497 29443494
Bronchiolitis obliterans syndrome 20.02 10.52 11 121525 159 29452832
Diaphragmatic injury 19.83 10.52 10 121526 120 29452871
Phlebitis infective 19.83 10.52 10 121526 120 29452871
Nasopharyngitis 19.80 10.52 350 121186 59315 29393676
Muscle rigidity 19.71 10.52 7 121529 9404 29443587
Hordeolum 19.61 10.52 20 121516 770 29452221
Hypogammaglobulinaemia 19.49 10.52 61 121475 5846 29447145
Leukaemia recurrent 19.37 10.52 27 121509 1450 29451541
Congenital herpes simplex infection 19.26 10.52 7 121529 34 29452957
Back disorder 19.08 10.52 61 121475 5912 29447079
Hypertension 19.00 10.52 351 121185 116263 29336728
Disturbance in attention 18.98 10.52 37 121499 21387 29431604
Diabetic ketoacidosis 18.80 10.52 23 121513 16050 29436941
Mucosal disorder 18.77 10.52 27 121509 1493 29451498
Stevens-Johnson syndrome 18.68 10.52 124 121412 16373 29436618
Immunodeficiency common variable 18.67 10.52 10 121526 137 29452854
Withdrawal syndrome 18.64 10.52 11 121525 10981 29442010
Corneal deposits 18.56 10.52 11 121525 185 29452806
Red blood cell sedimentation rate increased 18.52 10.52 4 121532 7457 29445534
Pneumonia influenzal 18.48 10.52 25 121511 1305 29451686
Bone marrow transplant 18.42 10.52 21 121515 919 29452072
Salivary hypersecretion 18.33 10.52 4 121532 7405 29445586
Surgery 18.32 10.52 13 121523 11766 29441225
Accessory spleen 18.30 10.52 10 121526 143 29452848
Atrial septal defect 18.21 10.52 3 121533 6786 29446205
Ventricular fibrillation 18.16 10.52 23 121513 15810 29437181
Staphylococcal bacteraemia 17.99 10.52 67 121469 7012 29445979
Blood immunoglobulin G decreased 17.98 10.52 23 121513 1136 29451855
Anaphylactic shock 17.91 10.52 17 121519 13319 29439672
Dry skin 17.90 10.52 160 121376 23147 29429844
Pulmonary embolism 17.82 10.52 426 121110 76108 29376883
Pancreatitis 17.82 10.52 77 121459 34437 29418554
Herpes simplex viraemia 17.77 10.52 8 121528 73 29452918
Product prescribing error 17.76 10.52 29 121507 17947 29435044
Epstein-Barr viraemia 17.74 10.52 21 121515 957 29452034
Device issue 17.70 10.52 5 121531 7775 29445216
Fungaemia 17.69 10.52 32 121504 2149 29450842
Plasma cell leukaemia 17.68 10.52 19 121517 778 29452213
Enterococcal sepsis 17.56 10.52 26 121510 1476 29451515
Cerebral infarction 17.52 10.52 48 121488 24627 29428364
Duodenal ulcer 17.51 10.52 8 121528 9230 29443761
Type 2 diabetes mellitus 17.45 10.52 18 121518 13563 29439428
Bone lesion 17.43 10.52 36 121500 2668 29450323
Schizophrenia 17.39 10.52 3 121533 6562 29446429
Headache 17.31 10.52 564 120972 173443 29279548
Product substitution issue 17.30 10.52 8 121528 9164 29443827
Poikiloderma 17.26 10.52 10 121526 161 29452830
Blood glucose increased 17.24 10.52 157 121379 58827 29394164
Mania 17.22 10.52 7 121529 8656 29444335
NPM1 gene mutation 17.22 10.52 9 121527 117 29452874
Haematopoietic stem cell mobilisation 17.15 10.52 10 121526 163 29452828
Cerebrovascular accident 17.13 10.52 218 121318 76693 29376298
Light chain disease 17.02 10.52 9 121527 120 29452871
Poisoning 16.94 10.52 10 121526 9983 29443008
Coronary artery stenosis 16.92 10.52 7 121529 8566 29444425
Malaise 16.92 10.52 513 121023 159089 29293902
Autoimmune haemolytic anaemia 16.84 10.52 44 121492 3804 29449187
Aspergillus infection 16.83 10.52 87 121449 10494 29442497
CNS ventriculitis 16.77 10.52 11 121525 223 29452768
Depressed mood 16.76 10.52 26 121510 16422 29436569
Musculoskeletal stiffness 16.74 10.52 88 121448 37370 29415621
Miosis 16.70 10.52 6 121530 8003 29444988
Immunodeficiency 16.68 10.52 48 121488 4392 29448599
Achromobacter infection 16.56 10.52 7 121529 54 29452937
Accidental exposure to product 16.55 10.52 12 121524 10741 29442250
Ischaemic stroke 16.53 10.52 25 121511 15952 29437039
Psychotic disorder 16.47 10.52 37 121499 20317 29432674
Blood potassium decreased 16.47 10.52 116 121420 15618 29437373
Cataract 16.36 10.52 152 121384 22226 29430765
Injection site haemorrhage 16.31 10.52 7 121529 8379 29444612
Toxic epidermal necrolysis 16.26 10.52 129 121407 18024 29434967
Cytomegalovirus chorioretinitis 16.25 10.52 39 121497 3199 29449792
Therapeutic response decreased 16.13 10.52 50 121486 24661 29428330
Escherichia sepsis 16.12 10.52 44 121492 3905 29449086
Oral herpes 16.07 10.52 48 121488 4484 29448507
Cytomegalovirus colitis 16.07 10.52 33 121503 2436 29450555
Metastases to liver 16.06 10.52 15 121521 11841 29441150
Erectile dysfunction 16.04 10.52 31 121505 17978 29435013
Congenital pneumonia 16.01 10.52 8 121528 94 29452897
Meningitis cryptococcal 16.01 10.52 30 121506 2070 29450921
Viral infection 15.98 10.52 110 121426 14700 29438291
Ventricular tachycardia 15.96 10.52 44 121492 22530 29430461
Hepatic encephalopathy 15.94 10.52 18 121518 13017 29439974
Sinusitis 15.81 10.52 213 121323 34137 29418854
Neuralgic amyotrophy 15.76 10.52 10 121526 191 29452800
Cardiac failure 15.76 10.52 230 121306 79057 29373934
Hypouricaemia 15.76 10.52 11 121525 248 29452743
Light chain analysis decreased 15.75 10.52 6 121530 34 29452957
Antiviral drug level above therapeutic 15.75 10.52 6 121530 34 29452957
Febrile infection 15.74 10.52 29 121507 1975 29451016
Protein total abnormal 15.65 10.52 12 121524 314 29452677
Angina unstable 15.61 10.52 13 121523 10852 29442139
Bone pain 15.38 10.52 129 121407 18323 29434668
Reticulocytosis 15.23 10.52 11 121525 262 29452729
Campylobacter gastroenteritis 15.19 10.52 17 121519 729 29452262
Acute generalised exanthematous pustulosis 15.17 10.52 54 121482 5529 29447462
Blood pressure decreased 15.11 10.52 117 121419 45360 29407631
Hyperhidrosis 15.10 10.52 181 121355 64359 29388632
Sideroblastic anaemia 15.02 10.52 10 121526 208 29452783
Transplant failure 14.98 10.52 35 121501 2821 29450170
Escherichia bacteraemia 14.97 10.52 35 121501 2823 29450168
Blood lactate dehydrogenase increased 14.82 10.52 132 121404 19077 29433914
Follicular mucinosis 14.73 10.52 5 121531 19 29452972
Liver function test 14.69 10.52 6 121530 42 29452949
Prostatic specific antigen increased 14.67 10.52 18 121518 12546 29440445
Knee arthroplasty 14.65 10.52 3 121533 5806 29447185
Pulmonary fibrosis 14.61 10.52 26 121510 15556 29437435
Therapy cessation 14.60 10.52 23 121513 14439 29438552
Haematemesis 14.59 10.52 52 121484 24574 29428417
Syncope 14.50 10.52 241 121295 81130 29371861
Chimerism 14.50 10.52 10 121526 221 29452770
Haematoma 14.43 10.52 48 121488 23164 29429827
Splenic embolism 14.41 10.52 9 121527 167 29452824
Palpitations 14.35 10.52 77 121459 32527 29420464
Lymphopenia 14.30 10.52 100 121436 13433 29439558
Gynaecomastia 14.25 10.52 8 121528 8209 29444782
Blood loss anaemia 14.23 10.52 6 121530 7260 29445731
Klebsiella bacteraemia 14.17 10.52 20 121516 1087 29451904
Therapeutic response unexpected 14.15 10.52 9 121527 8629 29444362
Herpes simplex encephalitis 14.15 10.52 11 121525 294 29452697
Pulmonary hypertension 14.12 10.52 35 121501 18573 29434418
Musculoskeletal pain 14.10 10.52 66 121470 28887 29424104
Fall 14.09 10.52 590 120946 176588 29276403
White blood cell count abnormal 14.07 10.52 34 121502 2801 29450190
Postural tremor 14.05 10.52 11 121525 297 29452694
Impaired work ability 14.05 10.52 3 121533 5637 29447354
Dyspnoea exertional 14.02 10.52 90 121446 36400 29416591
Hyperpyrexia 14.01 10.52 30 121506 2280 29450711
CSF protein increased 13.87 10.52 16 121520 709 29452282
Injection site swelling 13.87 10.52 11 121525 9406 29443585
Pancreatic carcinoma 13.85 10.52 6 121530 7144 29445847
Osteoarthritis 13.78 10.52 34 121502 18069 29434922
Gastric disorder 13.69 10.52 83 121453 10621 29442370
Eczema herpeticum 13.63 10.52 8 121528 132 29452859
Cardiac disorder 13.60 10.52 222 121314 37041 29415950
Gastroenteritis adenovirus 13.58 10.52 8 121528 133 29452858
Viral haemorrhagic cystitis 13.57 10.52 18 121518 922 29452069
Haematuria 13.55 10.52 116 121420 44023 29408968
Hallucination 13.50 10.52 118 121418 44594 29408397
CSF lactate increased 13.50 10.52 3 121533 0 29452991
Accidental overdose 13.42 10.52 33 121503 17560 29435431
Immunosuppression 13.41 10.52 50 121486 5236 29447755
Pallor 13.40 10.52 43 121493 20981 29432010
Blood phosphorus decreased 13.39 10.52 33 121503 2752 29450239
Injection site mass 13.39 10.52 3 121533 5452 29447539
Pneumocystis jirovecii pneumonia 13.30 10.52 116 121420 16663 29436328
Skin exfoliation 13.28 10.52 147 121389 22498 29430493
White blood cells urine positive 13.27 10.52 20 121516 1154 29451837
Product storage error 13.24 10.52 5 121531 6465 29446526
Haemophilus sepsis 13.17 10.52 5 121531 28 29452963
Neurological examination abnormal 13.13 10.52 10 121526 259 29452732
Agitation 13.13 10.52 141 121395 51163 29401828
Metastases to lung 13.12 10.52 8 121528 7847 29445144
Medication error 13.09 10.52 44 121492 21167 29431824
Myocardial ischaemia 13.08 10.52 29 121507 15999 29436992
Herpes zoster meningoencephalitis 13.06 10.52 10 121526 261 29452730
Oesophagopleural fistula 13.03 10.52 6 121530 58 29452933
Disseminated strongyloidiasis 13.00 10.52 7 121529 97 29452894
Graft versus host disease in liver 12.99 10.52 19 121517 1067 29451924
Neutrophil morphology abnormal 12.94 10.52 6 121530 59 29452932
Abnormal behaviour 12.94 10.52 50 121486 23077 29429914
Cardiomegaly 12.90 10.52 23 121513 13753 29439238
Pathological fracture 12.89 10.52 40 121496 3815 29449176
Polyarteritis nodosa 12.89 10.52 9 121527 203 29452788
Red blood cells urine positive 12.88 10.52 24 121512 1649 29451342
Asterixis 12.87 10.52 19 121517 1076 29451915
Road traffic accident 12.83 10.52 28 121508 15533 29437458
Marrow hyperplasia 12.82 10.52 18 121518 973 29452018
Eosinophil percentage increased 12.78 10.52 13 121523 499 29452492
Upper respiratory tract infection 12.75 10.52 170 121366 27179 29425812
Herpes simplex meningoencephalitis 12.75 10.52 4 121532 11 29452980
Neutrophil percentage decreased 12.74 10.52 11 121525 342 29452649
Hyperlipidaemia 12.73 10.52 20 121516 12570 29440421
Arteriosclerosis 12.72 10.52 14 121522 10242 29442749
Adenomatous polyposis coli 12.69 10.52 8 121528 151 29452840
Nightmare 12.66 10.52 17 121519 11400 29441591
Band neutrophil percentage increased 12.57 10.52 7 121529 104 29452887
Hip fracture 12.57 10.52 80 121456 10412 29442579
CSF cell count increased 12.49 10.52 5 121531 33 29452958
Bacterial test 12.47 10.52 8 121528 156 29452835
Flushing 12.46 10.52 69 121467 28923 29424068
Cardiovascular disorder 12.46 10.52 11 121525 8924 29444067
Anal cancer 12.44 10.52 11 121525 353 29452638
Haemoptysis 12.44 10.52 74 121462 30476 29422515
Blood triglycerides increased 12.41 10.52 21 121515 12813 29440178
Middle insomnia 12.38 10.52 4 121532 5704 29447287
Loss of personal independence in daily activities 12.38 10.52 58 121478 25382 29427609
Listeriosis 12.37 10.52 17 121519 901 29452090
Cataract subcapsular 12.37 10.52 11 121525 356 29452635
Varicella virus test positive 12.35 10.52 6 121530 66 29452925
Meningitis aseptic 12.33 10.52 29 121507 2347 29450644
Pyogenic granuloma 12.33 10.52 9 121527 218 29452773
Glomerulosclerosis 12.31 10.52 15 121521 705 29452286
Anger 12.30 10.52 16 121520 10874 29442117
Metastases to central nervous system 12.28 10.52 7 121529 7124 29445867
Blood immunoglobulin A increased 12.25 10.52 10 121526 287 29452704
Atrioventricular block complete 12.25 10.52 9 121527 8002 29444989
Epstein-Barr virus associated lymphoproliferative disorder 12.23 10.52 24 121512 1714 29451277
Rash maculo-papular 12.18 10.52 153 121383 24136 29428855
Ischaemic cardiomyopathy 12.15 10.52 4 121532 5634 29447357
Illness 12.13 10.52 57 121479 6617 29446374
Amyloidosis 12.13 10.52 26 121510 1978 29451013
Atrial flutter 12.05 10.52 98 121438 13796 29439195
Gastric fistula 12.05 10.52 6 121530 70 29452921
Chronic obstructive pulmonary disease 11.97 10.52 109 121427 40846 29412145
Thoracic vertebral fracture 11.97 10.52 21 121515 1377 29451614
Peritonitis 11.95 10.52 27 121509 14797 29438194
Mastitis 11.95 10.52 8 121528 168 29452823
Swollen tongue 11.92 10.52 20 121516 12246 29440745
Peptic ulcer haemorrhage 11.89 10.52 12 121524 456 29452535
Dyslipidaemia 11.88 10.52 5 121531 6056 29446935
Faeces discoloured 11.87 10.52 23 121513 13328 29439663
West Nile viral infection 11.86 10.52 14 121522 636 29452355
Vitamin B complex deficiency 11.83 10.52 8 121528 171 29452820
JC virus CSF test positive 11.80 10.52 7 121529 118 29452873
Hepatosplenomegaly neonatal 11.78 10.52 5 121531 39 29452952
Bronchitis 11.77 10.52 215 121321 36653 29416338
Renal failure 11.75 10.52 598 120938 118001 29334990
Lung neoplasm malignant 11.70 10.52 26 121510 14331 29438660
Idiopathic pneumonia syndrome 11.69 10.52 9 121527 237 29452754
pH urine increased 11.68 10.52 6 121530 75 29452916
Sleep disorder 11.63 10.52 56 121480 24330 29428661
Injection site erythema 11.60 10.52 25 121511 13931 29439060
Central nervous system lesion 11.59 10.52 50 121486 5598 29447393
Pain 11.58 10.52 581 120955 170851 29282140
Acute kidney injury 11.58 10.52 1252 120284 264015 29188976
Encephalomyelitis 11.57 10.52 5 121531 41 29452950
Gait disturbance 11.55 10.52 222 121314 73127 29379864
Eye infection fungal 11.47 10.52 10 121526 315 29452676
Lumbar puncture abnormal 11.43 10.52 3 121533 3 29452988
Selective IgG subclass deficiency 11.43 10.52 3 121533 3 29452988
Hepatic vein occlusion 11.40 10.52 7 121529 126 29452865
Chronic lymphocytic leukaemia transformation 11.40 10.52 8 121528 182 29452809
Dyslalia 11.39 10.52 12 121524 480 29452511
Vitamin B1 decreased 11.37 10.52 9 121527 247 29452744
Parkinsonism 11.36 10.52 8 121528 7270 29445721
Chills 11.31 10.52 378 121158 70922 29382069
Xerophthalmia 11.28 10.52 6 121530 81 29452910
Adult T-cell lymphoma/leukaemia 11.25 10.52 7 121529 129 29452862
Unresponsive to stimuli 11.24 10.52 59 121477 25067 29427924
Cytomegalovirus oesophagitis 11.19 10.52 11 121525 405 29452586
Embolism 11.18 10.52 57 121479 6839 29446152
Acanthamoeba infection 11.14 10.52 11 121525 407 29452584
Anhedonia 11.13 10.52 8 121528 7192 29445799
Rash papulosquamous 11.07 10.52 5 121531 46 29452945
Asphyxia 11.05 10.52 4 121532 5311 29447680
Chronic kidney disease 11.04 10.52 96 121440 36320 29416671
Gastric ulcer 11.02 10.52 26 121510 14035 29438956
Post procedural complication 10.99 10.52 16 121520 10373 29442618
Pemphigoid 10.98 10.52 9 121527 7572 29445419
Injection site bruising 10.98 10.52 9 121527 7571 29445420
Retinitis viral 10.97 10.52 6 121530 86 29452905
Cystitis viral 10.92 10.52 12 121524 504 29452487
Alveolitis necrotising 10.91 10.52 4 121532 20 29452971
Shock 10.89 10.52 48 121488 21356 29431635
Auditory disorder 10.89 10.52 9 121527 263 29452728
Aspergillus test positive 10.80 10.52 11 121525 423 29452568
Aplasia 10.78 10.52 39 121497 4024 29448967
Bacterial sepsis 10.72 10.52 43 121493 4660 29448331
Haemorrhage 10.69 10.52 126 121410 44946 29408045
Obstructive airways disorder 10.67 10.52 18 121518 10998 29441993
Urine ketone body present 10.65 10.52 17 121519 1031 29451960
Kidney fibrosis 10.64 10.52 25 121511 2022 29450969
Upper gastrointestinal haemorrhage 10.64 10.52 50 121486 21864 29431127
Joint stiffness 10.61 10.52 14 121522 9459 29443532
Hyponatraemia 10.56 10.52 205 121331 67428 29385563

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Plasma cell myeloma 1909.66 9.95 1377 195411 44698 64257246
Febrile neutropenia 1097.03 9.95 2014 194774 185643 64116301
White blood cell count decreased 760.52 9.95 1562 195226 156275 64145669
Platelet count decreased 697.94 9.95 1564 195224 166147 64135797
Pneumonia 664.50 9.95 3411 193377 556165 63745779
Neutropenia 565.81 9.95 1811 194977 237813 64064131
Pyrexia 533.58 9.95 3212 193576 555432 63746512
Completed suicide 510.16 9.95 48 196740 224366 64077578
Cytokine release syndrome 506.57 9.95 456 196332 20373 64281571
Neurotoxicity 485.45 9.95 504 196284 26900 64275044
Neutrophil count decreased 476.10 9.95 849 195939 76347 64225597
Lymphocyte count decreased 458.89 9.95 593 196195 40106 64261838
Urine abnormality 382.26 9.95 253 196535 7109 64294835
Thrombocytopenia 377.75 9.95 1516 195272 222285 64079659
Neuropathy peripheral 375.01 9.95 990 195798 116535 64185409
Rheumatoid arthritis 371.01 9.95 36 196752 164258 64137686
Full blood count decreased 355.23 9.95 390 196398 22192 64279752
Cytomegalovirus infection 336.17 9.95 487 196301 36712 64265232
Drug abuse 333.40 9.95 17 196771 132357 64169587
Graft versus host disease 321.34 9.95 295 196493 13518 64288426
Toxicity to various agents 321.28 9.95 382 196406 363131 63938813
Pancytopenia 299.32 9.95 1040 195748 142269 64159675
Arthralgia 281.99 9.95 579 196209 441681 63860263
Synovitis 277.04 9.95 5 196783 99085 64202859
Contraindicated product administered 264.86 9.95 16 196772 107813 64194131
Sepsis 261.30 9.95 1389 195399 228952 64072992
Urine leukocyte esterase positive 255.68 9.95 148 196640 3255 64298689
Crystal urine present 229.78 9.95 114 196674 1815 64300129
Joint swelling 224.56 9.95 196 196592 215186 64086758
Urinary sediment present 222.47 9.95 117 196671 2117 64299827
White blood cells urine positive 215.77 9.95 158 196630 5240 64296704
Drug intolerance 212.30 9.95 158 196630 187834 64114110
Acute graft versus host disease 211.28 9.95 194 196594 8890 64293054
Drug ineffective 200.03 9.95 1625 195163 838622 63463322
Drug hypersensitivity 197.25 9.95 262 196526 237553 64064391
Red blood cells urine positive 197.16 9.95 139 196649 4339 64297605
Thrombosis 193.42 9.95 563 196225 70079 64231865
Lymphocyte percentage decreased 192.47 9.95 139 196649 4510 64297434
Pathogen resistance 189.28 9.95 212 196576 12331 64289613
Therapeutic product effect decreased 187.79 9.95 59 196729 115292 64186652
Pain 185.08 9.95 965 195823 552546 63749398
Urine analysis abnormal 180.82 9.95 146 196642 5610 64296334
Encephalitis viral 180.11 9.95 104 196684 2276 64299668
Intentional overdose 178.17 9.95 30 196758 89914 64212030
Neutrophil percentage increased 177.43 9.95 130 196658 4315 64297629
Meningoencephalitis herpetic 171.88 9.95 91 196697 1670 64300274
Cytomegalovirus viraemia 168.53 9.95 186 196602 10642 64291302
Systemic lupus erythematosus 165.04 9.95 21 196767 77591 64224353
Pemphigus 162.22 9.95 5 196783 60696 64241248
Injection site pain 157.91 9.95 71 196717 111337 64190607
Bronchopulmonary aspergillosis 156.80 9.95 239 196549 18846 64283098
Drug interaction 151.08 9.95 581 196207 361502 63940442
Mucosal inflammation 145.40 9.95 471 196317 62113 64239831
Drug resistance 145.23 9.95 327 196461 34775 64267169
Deep vein thrombosis 144.41 9.95 670 196118 104512 64197432
Blood urine present 142.73 9.95 224 196564 18116 64283828
Multiple organ dysfunction syndrome 139.24 9.95 646 196142 100767 64201177
Acute graft versus host disease in skin 137.70 9.95 135 196653 6720 64295224
Herpes simplex 135.44 9.95 164 196624 10372 64291572
Intentional product misuse 134.88 9.95 28 196760 72267 64229677
Treatment failure 132.05 9.95 98 196690 116718 64185226
Acute graft versus host disease in intestine 127.26 9.95 98 196690 3511 64298433
Bacterial test 125.29 9.95 65 196723 1142 64300802
Rash 124.60 9.95 2027 194761 456522 63845422
Encephalitis 124.51 9.95 172 196616 12399 64289545
Discomfort 123.59 9.95 46 196742 80832 64221112
Tumour lysis syndrome 122.55 9.95 216 196572 19224 64282720
Arthropathy 121.31 9.95 114 196674 120853 64181091
Overdose 121.14 9.95 187 196601 159379 64142565
Epstein-Barr virus infection 120.90 9.95 169 196619 12319 64289625
Acute kidney injury 119.87 9.95 1980 194808 447260 63854684
Wound 117.70 9.95 43 196745 76434 64225510
Septic shock 117.40 9.95 633 196155 104804 64197140
Acute myeloid leukaemia 117.15 9.95 259 196529 27204 64274740
Maternal exposure during pregnancy 116.95 9.95 74 196714 95810 64206134
Alopecia 116.63 9.95 204 196584 165486 64136458
Condition aggravated 113.98 9.95 668 196120 371758 63930186
Post transplant lymphoproliferative disorder 113.73 9.95 143 196645 9401 64292543
Bacterial test positive 113.00 9.95 120 196668 6570 64295374
Glossodynia 110.94 9.95 30 196758 64666 64237278
Urine ketone body present 110.54 9.95 87 196701 3220 64298724
Neutropenic sepsis 110.22 9.95 229 196559 23043 64278901
Acute myeloid leukaemia recurrent 107.92 9.95 80 196708 2704 64299240
Cystitis haemorrhagic 107.46 9.95 127 196661 7829 64294115
Nephropathy toxic 107.06 9.95 192 196596 17322 64284622
Pre-engraftment immune reaction 107.02 9.95 40 196748 301 64301643
Haematotoxicity 105.23 9.95 161 196627 12735 64289209
Suicide attempt 104.19 9.95 43 196745 70964 64230980
Immune effector cell-associated neurotoxicity syndrome 103.82 9.95 76 196712 2519 64299425
Chronic graft versus host disease 103.23 9.95 111 196677 6165 64295779
Plasma cell myeloma recurrent 102.78 9.95 91 196697 3974 64297970
Laboratory test abnormal 101.59 9.95 226 196562 23837 64278107
Inappropriate schedule of product administration 101.00 9.95 80 196708 92206 64209738
Crystalluria 98.26 9.95 49 196739 789 64301155
Encephalopathy 97.79 9.95 397 196391 58422 64243522
Cytopenia 97.65 9.95 172 196616 15299 64286645
Hypoglycaemia 97.03 9.95 79 196709 89813 64212131
Pain in extremity 96.80 9.95 536 196252 302549 63999395
Culture urine positive 95.27 9.95 88 196700 4063 64297881
Swelling 94.98 9.95 218 196570 160000 64141944
Pneumonia fungal 94.81 9.95 126 196662 8751 64293193
Human herpesvirus 6 infection 92.26 9.95 91 196697 4563 64297381
Duodenal ulcer perforation 91.99 9.95 3 196785 34622 64267322
Haemoglobin urine present 91.09 9.95 47 196741 816 64301128
Monocyte percentage increased 90.18 9.95 63 196725 1937 64300007
Lymphopenia 89.84 9.95 224 196564 25433 64276511
Cytomegalovirus infection reactivation 88.06 9.95 98 196690 5658 64296286
Adenovirus infection 86.92 9.95 109 196679 7146 64294798
Chronic lymphocytic leukaemia 86.71 9.95 85 196703 4230 64297714
Wrong technique in product usage process 86.57 9.95 45 196743 64929 64237015
Suicidal ideation 85.86 9.95 48 196740 66494 64235450
Psoriasis 85.17 9.95 57 196731 71646 64230298
Helicobacter infection 84.99 9.95 9 196779 38353 64263591
Stem cell transplant 84.19 9.95 76 196712 3405 64298539
Hypersensitivity 83.24 9.95 313 196475 196139 64105805
Red blood cell count decreased 83.16 9.95 330 196458 48056 64253888
Psoriatic arthropathy 82.32 9.95 16 196772 43265 64258679
Arthritis 79.40 9.95 83 196705 83731 64218213
Red cell distribution width increased 79.18 9.95 138 196650 12171 64289773
Abdominal discomfort 78.21 9.95 289 196499 182033 64119911
Diarrhoea 77.99 9.95 2813 193975 719891 63582053
Blood pressure systolic increased 77.46 9.95 27 196761 49426 64252518
Toxoplasmosis 76.78 9.95 62 196726 2382 64299562
International normalised ratio increased 76.58 9.95 77 196711 79090 64222854
Haemophagocytic lymphohistiocytosis 73.90 9.95 165 196623 17444 64284500
Dyspnoea 73.69 9.95 1652 195136 717022 63584922
Light chain analysis increased 72.91 9.95 47 196741 1261 64300683
Specific gravity urine decreased 72.31 9.95 39 196749 744 64301200
Sensitisation 72.21 9.95 52 196736 1679 64300265
Myocardial infarction 71.67 9.95 262 196526 165559 64136385
Smooth muscle cell neoplasm 71.34 9.95 40 196748 826 64301118
Enterococcal infection 71.07 9.95 141 196647 13725 64288219
Venoocclusive liver disease 70.66 9.95 117 196671 9898 64292046
Musculoskeletal stiffness 70.32 9.95 171 196617 123035 64178909
Toxic encephalopathy 68.36 9.95 114 196674 9701 64292243
Blood pressure fluctuation 67.53 9.95 37 196751 51834 64250110
Injection site erythema 67.19 9.95 70 196718 70730 64231214
Impaired healing 66.70 9.95 52 196736 60421 64241523
Intentional self-injury 66.48 9.95 6 196782 29038 64272906
Nitrite urine present 65.95 9.95 41 196747 1031 64300913
Sopor 65.60 9.95 7 196781 29654 64272290
Pericarditis 64.94 9.95 57 196731 62459 64239485
Aspergillus infection 64.87 9.95 150 196638 16229 64285715
Influenza 64.46 9.95 550 196238 105981 64195963
Sedation 64.32 9.95 23 196765 41439 64260505
Thrombotic microangiopathy 64.29 9.95 151 196637 16504 64285440
C-reactive protein abnormal 63.87 9.95 7 196781 29040 64272904
Constipation 63.64 9.95 1018 195770 228319 64073625
Weight increased 63.40 9.95 386 196402 212962 64088982
Encephalitis cytomegalovirus 63.25 9.95 39 196749 966 64300978
Mucormycosis 63.24 9.95 94 196694 7247 64294697
Pneumonia cytomegaloviral 63.18 9.95 72 196716 4267 64297677
Herpes virus infection 62.69 9.95 86 196702 6158 64295786
Respiratory syncytial virus infection 62.52 9.95 93 196695 7175 64294769
Ophthalmic herpes simplex 62.20 9.95 32 196756 552 64301392
Injection site bruising 62.10 9.95 17 196771 36356 64265588
Respiratory failure 61.91 9.95 758 196030 160425 64141519
Rhabdomyolysis 61.77 9.95 116 196672 91610 64210334
Cytomegalovirus test positive 61.17 9.95 77 196711 5067 64296877
Injection site reaction 61.16 9.95 33 196755 46631 64255313
Bacteraemia 61.10 9.95 201 196587 26710 64275234
Specific gravity urine increased 61.08 9.95 29 196759 417 64301527
Knee arthroplasty 60.67 9.95 6 196782 26993 64274951
Herpes zoster 60.16 9.95 431 196357 78756 64223188
Polycystic ovaries 60.06 9.95 51 196737 2104 64299840
Product use issue 59.62 9.95 249 196539 151466 64150478
Intentional product use issue 58.75 9.95 127 196661 95237 64206707
Blood pressure increased 57.87 9.95 300 196488 172252 64129692
Plasmacytoma 57.68 9.95 65 196723 3805 64298139
Injection site swelling 57.57 9.95 27 196761 41326 64260618
Engraftment syndrome 57.17 9.95 38 196750 1075 64300869
Blood bilirubin increased 57.05 9.95 335 196453 57218 64244726
Red blood cell sedimentation rate increased 56.42 9.95 13 196775 31222 64270722
Diffuse large B-cell lymphoma 56.32 9.95 108 196680 10253 64291691
Drug dependence 56.07 9.95 16 196772 33296 64268648
Mobility decreased 55.67 9.95 111 196677 85729 64216215
Ejection fraction 54.49 9.95 39 196749 1247 64300697
Organic brain syndrome 54.35 9.95 27 196761 431 64301513
Irritable bowel syndrome 54.22 9.95 23 196765 37346 64264598
Graft versus host disease in skin 54.21 9.95 74 196714 5273 64296671
Varicella zoster virus infection 54.06 9.95 63 196725 3825 64298119
Clostridium difficile colitis 53.66 9.95 194 196594 27029 64274915
Cardio-respiratory arrest 53.47 9.95 140 196648 98253 64203691
Therapeutic product effect incomplete 53.42 9.95 151 196637 103331 64198613
Graft versus host disease in gastrointestinal tract 52.91 9.95 75 196713 5537 64296407
Malaise 51.37 9.95 875 195913 395372 63906572
Depression 51.17 9.95 338 196450 182953 64118991
Blood creatinine increased 50.60 9.95 635 196153 135147 64166797
Lactic acidosis 49.47 9.95 69 196719 61341 64240603
Sleep disorder due to general medical condition, insomnia type 49.35 9.95 10 196778 26260 64275684
Necrotising retinitis 49.14 9.95 34 196754 1029 64300915
Oxygen saturation decreased 48.52 9.95 166 196622 107010 64194934
Venoocclusive disease 47.94 9.95 60 196728 3925 64298019
Muscle injury 47.76 9.95 11 196777 26426 64275518
Escherichia bacteraemia 47.72 9.95 70 196718 5333 64296611
Haemoglobin decreased 47.21 9.95 847 195941 194216 64107728
Acute graft versus host disease in liver 47.17 9.95 40 196748 1647 64300297
Injury 47.05 9.95 61 196727 55931 64246013
Musculoskeletal pain 47.03 9.95 112 196676 81182 64220762
Atrial fibrillation 46.89 9.95 758 196030 170331 64131613
Rash maculo-papular 46.79 9.95 274 196514 46752 64255192
Hyperbilirubinaemia 46.02 9.95 156 196632 21049 64280895
CSF protein increased 45.65 9.95 33 196755 1072 64300872
COVID-19 pneumonia 45.58 9.95 132 196656 16372 64285572
Off label use 45.45 9.95 1529 195259 631277 63670667
Infusion related reaction 45.04 9.95 305 196483 164162 64137782
Type 2 diabetes mellitus 44.67 9.95 24 196764 33996 64267948
Anaphylactic reaction 44.34 9.95 89 196699 68575 64233369
Acute lymphocytic leukaemia recurrent 44.32 9.95 58 196730 3968 64297976
Fall 43.17 9.95 956 195832 415870 63886074
Blood creatine phosphokinase increased 43.10 9.95 70 196718 58488 64243456
Neuroleptic malignant syndrome 42.08 9.95 12 196776 24984 64276960
Hepatic enzyme increased 41.84 9.95 229 196559 129714 64172230
Factor XIII deficiency 41.32 9.95 14 196774 76 64301868
Parainfluenzae virus infection 41.24 9.95 61 196727 4682 64297262
Thyroxine free increased 41.10 9.95 31 196757 1076 64300868
Osteoarthritis 40.98 9.95 82 196706 63254 64238690
Body temperature decreased 40.87 9.95 14 196774 25914 64276030
Acute generalised exanthematous pustulosis 40.34 9.95 114 196674 13944 64288000
Electrocardiogram QT prolonged 40.22 9.95 117 196671 79331 64222613
Antiviral drug level above therapeutic 40.07 9.95 12 196776 40 64301904
Metabolic acidosis 40.07 9.95 99 196689 70859 64231085
Injection site pruritus 39.87 9.95 34 196754 37792 64264152
Drug withdrawal syndrome 39.75 9.95 23 196765 31268 64270676
Bacterial infection 39.56 9.95 166 196622 24784 64277160
Urinary casts 39.51 9.95 30 196758 1052 64300892
Hypogammaglobulinaemia 39.34 9.95 93 196695 10206 64291738
Respiratory arrest 39.32 9.95 63 196725 52922 64249022
Engraft failure 39.19 9.95 24 196764 587 64301357
Pleocytosis 38.90 9.95 30 196758 1077 64300867
Weight decreased 38.62 9.95 626 196162 285113 64016831
General physical health deterioration 38.53 9.95 418 196370 204007 64097937
Bacterial sepsis 38.42 9.95 76 196712 7381 64294563
Hip arthroplasty 38.34 9.95 9 196779 21342 64280602
Labelled drug-drug interaction medication error 38.25 9.95 10 196778 22052 64279892
Mantle cell lymphoma 37.94 9.95 30 196758 1118 64300826
Fusarium infection 37.44 9.95 34 196754 1535 64300409
Red cell distribution width decreased 37.06 9.95 29 196759 1064 64300880
Taste disorder 36.93 9.95 86 196702 9347 64292597
Staphylococcal bacteraemia 36.87 9.95 91 196697 10264 64291680
Blood thyroid stimulating hormone decreased 36.76 9.95 61 196727 5169 64296775
Renal failure 36.51 9.95 767 196021 180921 64121023
Obesity 36.27 9.95 9 196779 20553 64281391
Blood test abnormal 36.21 9.95 104 196684 12839 64289105
Mean cell haemoglobin decreased 35.82 9.95 53 196735 4069 64297875
Underdose 35.74 9.95 17 196771 25812 64276132
Blood lactate dehydrogenase increased 35.71 9.95 197 196591 32881 64269063
Chills 35.70 9.95 603 196185 136661 64165283
Gastrointestinal haemorrhage 35.41 9.95 247 196541 132065 64169879
Injection site haemorrhage 35.13 9.95 15 196773 24263 64277681
Therapeutic response decreased 35.13 9.95 66 196722 52122 64249822
Anaphylactic shock 34.83 9.95 25 196763 30303 64271641
Transplant failure 34.74 9.95 50 196738 3744 64298200
Haematocrit decreased 34.54 9.95 285 196503 54370 64247574
Band neutrophil percentage increased 34.29 9.95 19 196769 383 64301561
Graft versus host disease in liver 34.07 9.95 32 196756 1509 64300435
Foot deformity 33.81 9.95 5 196783 16499 64285445
Pneumonia influenzal 33.63 9.95 40 196748 2482 64299462
Muscle spasms 33.62 9.95 611 196177 140412 64161532
Blood thyroid stimulating hormone increased 33.56 9.95 73 196715 7581 64294363
Melaena 33.23 9.95 71 196717 53477 64248467
Urine leukocyte esterase 33.06 9.95 14 196774 151 64301793
Staphylococcal infection 32.96 9.95 266 196522 50412 64251532
Central nervous system lesion 32.95 9.95 95 196693 11754 64290190
Incorrect route of product administration 32.75 9.95 15 196773 23283 64278661
Renal disorder 32.59 9.95 202 196586 35163 64266781
Aplastic anaemia 32.52 9.95 105 196683 13815 64288129
Joint stiffness 32.45 9.95 27 196761 30377 64271567
Rash pruritic 32.44 9.95 292 196496 57112 64244832
Band sensation 32.35 9.95 22 196766 647 64301297
Breast cancer 32.22 9.95 25 196763 29123 64272821
COVID-19 32.16 9.95 322 196466 64818 64237126
Exposure during pregnancy 32.06 9.95 125 196663 77550 64224394
Bilirubin urine present 32.06 9.95 17 196771 313 64301631
Streptococcal bacteraemia 31.94 9.95 43 196745 3024 64298920
Pulmonary thrombosis 31.87 9.95 87 196701 10431 64291513
Inflammation 31.73 9.95 98 196690 65202 64236742
Somnolence 31.69 9.95 434 196354 203211 64098733
Myalgia 31.65 9.95 320 196468 158297 64143647
Injection site mass 31.57 9.95 7 196781 17263 64284681
Infusion site pain 31.50 9.95 86 196702 10311 64291633
Meningitis aseptic 31.48 9.95 60 196728 5670 64296274
Pulmonary embolism 31.43 9.95 624 196164 145732 64156212
Accidental exposure to product 31.24 9.95 21 196767 26343 64275601
Protein urine present 31.15 9.95 78 196710 8878 64293066
Leukaemia recurrent 31.12 9.95 39 196749 2555 64299389
Interstitial lung disease 31.04 9.95 173 196615 97559 64204385
Metastases to bone 30.58 9.95 12 196776 20423 64281521
Device malfunction 30.56 9.95 8 196780 17625 64284319
Blood cholesterol increased 30.56 9.95 67 196721 49999 64251945
Cells in urine 30.54 9.95 14 196774 185 64301759
Anxiety 30.42 9.95 435 196353 202214 64099730
Leukocyturia 30.35 9.95 30 196758 1508 64300436
Osteoporosis 30.32 9.95 51 196737 42029 64259915
pH urine increased 30.30 9.95 18 196770 416 64301528
Pneumonia respiratory syncytial viral 30.28 9.95 29 196759 1402 64300542
Blood potassium decreased 30.16 9.95 219 196569 40180 64261764
Plasma cell leukaemia 30.11 9.95 30 196758 1523 64300421
Differentiation syndrome 29.77 9.95 34 196754 2020 64299924
Monocyte count decreased 29.66 9.95 40 196748 2817 64299127
Anaemia 29.45 9.95 1425 195363 377255 63924689
Immune thrombocytopenia 29.38 9.95 107 196681 14959 64286985
Folliculitis 29.37 9.95 29 196759 30048 64271896
Treatment noncompliance 29.25 9.95 55 196733 43427 64258517
Toxic epidermal necrolysis 29.21 9.95 204 196584 36962 64264982
Mean cell haemoglobin concentration increased 29.13 9.95 22 196766 765 64301179
Surgery 28.96 9.95 26 196762 28187 64273757
Dyslalia 28.87 9.95 24 196764 961 64300983
Encephalitis autoimmune 28.69 9.95 32 196756 1852 64300092
Ageusia 28.56 9.95 100 196688 13713 64288231
Herpes simplex encephalitis 28.46 9.95 20 196768 621 64301323
Epstein-Barr virus associated lymphoproliferative disorder 28.40 9.95 41 196747 3078 64298866
Antineutrophil cytoplasmic antibody positive 28.30 9.95 24 196764 988 64300956
Campylobacter gastroenteritis 28.25 9.95 25 196763 1091 64300853
Pneumocystis jirovecii pneumonia 28.13 9.95 162 196626 27472 64274472
Squamous cell carcinoma of skin 28.12 9.95 90 196698 11786 64290158
Systemic mycosis 27.99 9.95 35 196753 2288 64299656
Vomiting 27.66 9.95 1387 195401 549730 63752214
Cardiogenic shock 27.58 9.95 35 196753 32392 64269552
Listeriosis 27.52 9.95 32 196756 1938 64300006
Cardiac arrest 27.45 9.95 319 196469 153745 64148199
Rectal haemorrhage 27.13 9.95 97 196691 61720 64240224
Acute myocardial infarction 27.01 9.95 115 196673 69603 64232341
Pseudomonal sepsis 27.00 9.95 53 196735 5119 64296825
Fungal infection 26.92 9.95 188 196600 34063 64267881
Device issue 26.89 9.95 18 196770 22630 64279314
Fatigue 26.82 9.95 2641 194147 746089 63555855
Primary myelofibrosis 26.71 9.95 11 196777 110 64301834
Blood loss anaemia 26.70 9.95 5 196783 13887 64288057
CD4 lymphocytes decreased 26.68 9.95 35 196753 2400 64299544
Aspartate aminotransferase 26.66 9.95 13 196775 199 64301745
Pulmonary arterial hypertension 26.49 9.95 23 196765 25344 64276600
Wheezing 26.49 9.95 141 196647 80438 64221506
Infection 26.42 9.95 745 196043 184135 64117809
Ulcer 26.33 9.95 19 196769 22971 64278973
Eczema herpeticum 26.31 9.95 13 196775 205 64301739
Multiple sclerosis relapse 26.26 9.95 215 196573 40920 64261024
Candida infection 26.21 9.95 175 196613 31244 64270700
Hepatic cirrhosis 26.09 9.95 25 196763 26273 64275671
Respiratory depression 26.05 9.95 20 196768 23423 64278521
Blood pressure diastolic abnormal 25.88 9.95 3 196785 11914 64290030
Metastases to liver 25.87 9.95 21 196767 23920 64278024
Band neutrophil count increased 25.79 9.95 19 196769 636 64301308
Medication error 25.71 9.95 73 196715 49893 64252051
Product quality issue 25.51 9.95 32 196756 29767 64272177
Magnetic resonance imaging abnormal 25.49 9.95 39 196749 3084 64298860
Creutzfeldt-Jakob disease 25.43 9.95 12 196776 170 64301774
Lower respiratory tract infection fungal 25.41 9.95 21 196767 834 64301110
Abdominal wall infection 25.40 9.95 10 196778 88 64301856
Pneumonia bacterial 25.39 9.95 102 196686 14933 64287011
Meningitis 25.34 9.95 69 196719 8260 64293684
Viral haemorrhagic cystitis 25.29 9.95 28 196760 1607 64300337
Clostridium difficile infection 25.27 9.95 193 196595 35970 64265974
Cytomegalovirus chorioretinitis 25.23 9.95 50 196738 4862 64297082
Gastrointestinal disorder 25.23 9.95 165 196623 89544 64212400
Dystonia 25.22 9.95 13 196775 18852 64283092
Lipaemic index score 25.01 9.95 11 196777 131 64301813
Depressed mood 24.93 9.95 55 196733 40957 64260987
Diabetes mellitus 24.93 9.95 111 196677 66363 64235581
Herpes zoster meningoencephalitis 24.91 9.95 19 196769 671 64301273
Febrile infection 24.78 9.95 37 196751 2864 64299080
Klebsiella bacteraemia 24.66 9.95 33 196755 2307 64299637
Pulmonary fibrosis 24.64 9.95 33 196755 29845 64272099
Pseudomonas infection 24.57 9.95 114 196674 17769 64284175
Enterococcal sepsis 24.51 9.95 34 196754 2460 64299484
Hospitalisation 24.50 9.95 132 196656 75075 64226869
Escherichia sepsis 24.50 9.95 62 196726 7103 64294841
Cyanosis 24.49 9.95 19 196769 22136 64279808
Mental status changes 24.49 9.95 290 196498 60872 64241072
Pleural effusion 24.35 9.95 531 196257 126028 64175916
Herpes simplex viraemia 24.29 9.95 13 196775 244 64301700
Geotrichum infection 24.11 9.95 21 196767 897 64301047
Loss of personal independence in daily activities 23.69 9.95 127 196661 72327 64229617
Posterior reversible encephalopathy syndrome 23.67 9.95 135 196653 22811 64279133
Anti-thyroid antibody positive 23.66 9.95 16 196772 466 64301478
Extravasation 23.58 9.95 38 196750 3142 64298802
Systemic candida 23.56 9.95 51 196737 5278 64296666
Blood pressure diastolic decreased 23.56 9.95 20 196768 22281 64279663
Monoclonal immunoglobulin present 23.55 9.95 20 196768 825 64301119
Post herpetic neuralgia 23.52 9.95 32 196756 2273 64299671
Red blood cells urine 23.51 9.95 18 196770 639 64301305
Muscle rigidity 23.42 9.95 12 196776 17461 64284483
Bone marrow transplant 23.37 9.95 24 196764 1263 64300681
Angioedema 23.32 9.95 103 196685 61718 64240226
Anti-platelet antibody positive 23.29 9.95 13 196775 266 64301678
Coronary artery disease 23.22 9.95 100 196688 60333 64241611
Skin exfoliation 23.19 9.95 224 196564 44661 64257283
Epstein-Barr viraemia 23.14 9.95 28 196760 1769 64300175
Nephrectomy 23.12 9.95 25 196763 1397 64300547
Angina pectoris 23.09 9.95 66 196722 45015 64256929
Eosinophil percentage increased 23.09 9.95 25 196763 1399 64300545
Bursitis 23.03 9.95 19 196769 21466 64280478
Miosis 23.03 9.95 6 196782 13260 64288684
Strongyloidiasis 23.02 9.95 37 196751 3053 64298891
Tendonitis 22.92 9.95 17 196771 20265 64281679
Disseminated mucormycosis 22.90 9.95 16 196772 492 64301452
Urine oxalate increased 22.77 9.95 12 196776 218 64301726
Tri-iodothyronine free decreased 22.70 9.95 14 196774 347 64301597
Diaphragmatic injury 22.67 9.95 10 196778 120 64301824
Varicella virus test positive 22.52 9.95 11 196777 169 64301775
Meningitis cryptococcal 22.37 9.95 36 196752 2973 64298971
Herpes ophthalmic 22.33 9.95 23 196765 1215 64300729
Parkinsonism 22.25 9.95 8 196780 14365 64287579
Tri-iodothyronine free increased 22.24 9.95 12 196776 229 64301715
Chest pain 22.21 9.95 549 196239 235431 64066513
Status epilepticus 22.05 9.95 127 196661 21536 64280408
Blood pressure decreased 22.04 9.95 163 196625 86036 64215908
Aggression 22.02 9.95 70 196718 46162 64255782
Mean cell haemoglobin concentration decreased 22.02 9.95 40 196748 3644 64298300
NPM1 gene mutation 21.96 9.95 10 196778 130 64301814
Acute lymphocytic leukaemia 21.86 9.95 44 196744 4327 64297617
CSF measles antibody positive 21.78 9.95 8 196780 57 64301887
Red blood cell count increased 21.76 9.95 39 196749 3516 64298428
Blast cell count increased 21.70 9.95 23 196765 1256 64300688
Ill-defined disorder 21.48 9.95 66 196722 43986 64257958
Enterococcal bacteraemia 21.47 9.95 32 196756 2473 64299471
Diabetes mellitus inadequate control 21.47 9.95 20 196768 21301 64280643
Loss of consciousness 21.38 9.95 321 196467 148044 64153900
Nervous system disorder 21.38 9.95 132 196656 22946 64278998
Rubella antibody positive 21.31 9.95 8 196780 61 64301883
Serotonin syndrome 21.25 9.95 56 196732 39226 64262718
Fungaemia 21.24 9.95 40 196748 3745 64298199
Metastases to lung 21.19 9.95 10 196778 15254 64286690
Neutropenic infection 21.15 9.95 28 196760 1937 64300007
Cardiac failure congestive 21.13 9.95 276 196512 130304 64171640
Pneumonia viral 21.06 9.95 62 196726 7760 64294184
Hiatus hernia 20.96 9.95 18 196770 19939 64282005
Thyroid stimulating immunoglobulin 20.87 9.95 8 196780 65 64301879
Lymph node palpable 20.87 9.95 10 196778 147 64301797
Cytokine storm 20.74 9.95 19 196769 868 64301076
Asthma 20.73 9.95 188 196600 95037 64206907
Chimerism 20.72 9.95 12 196776 264 64301680
Alanine aminotransferase increased 20.62 9.95 563 196225 138468 64163476
Colitis ulcerative 20.49 9.95 24 196764 23004 64278940
Premature delivery 20.47 9.95 16 196772 18573 64283371
Neutrophil Pelger-Huet anomaly present 20.46 9.95 13 196775 340 64301604
Stress 20.41 9.95 105 196683 60429 64241515
Blood pressure systolic abnormal 20.39 9.95 3 196785 9939 64292005
Joint injury 20.32 9.95 24 196764 22923 64279021
Cytomegalovirus colitis 20.20 9.95 40 196748 3888 64298056
Hyperkalaemia 20.17 9.95 204 196584 100925 64201019
Gait disturbance 20.09 9.95 387 196401 171768 64130176
Blood creatinine decreased 20.06 9.95 57 196731 6993 64294951
Acute disseminated encephalomyelitis 19.80 9.95 12 196776 288 64301656
Obstructive airways disorder 19.74 9.95 25 196763 23160 64278784
Neutrophil percentage decreased 19.66 9.95 17 196771 719 64301225
Aplasia 19.58 9.95 56 196732 6897 64295047
Idiopathic pneumonia syndrome 19.56 9.95 15 196773 534 64301410
Swollen tongue 19.55 9.95 49 196739 34905 64267039
Injection site urticaria 19.51 9.95 5 196783 11176 64290768
Target skin lesion 19.49 9.95 9 196779 121 64301823
Oral herpes 19.46 9.95 125 196663 22027 64279917
Paranoia 19.41 9.95 13 196775 16339 64285605
Stevens-Johnson syndrome 19.23 9.95 174 196614 34075 64267869
Duodenal ulcer 19.22 9.95 10 196778 14425 64287519
Focal myositis 19.19 9.95 6 196782 24 64301920
Pneumonia pneumococcal 19.18 9.95 35 196753 3199 64298745
Myelocyte percentage increased 19.08 9.95 11 196777 240 64301704
Fear 19.07 9.95 20 196768 20151 64281793
Staphylococcal sepsis 19.05 9.95 84 196704 12815 64289129
Blood brain barrier defect 18.98 9.95 9 196779 129 64301815
Monocyte count increased 18.93 9.95 61 196727 8018 64293926
Therapy interrupted 18.79 9.95 20 196768 20016 64281928
Needle issue 18.56 9.95 3 196785 9269 64292675
Herpes zoster meningitis 18.50 9.95 9 196779 137 64301807
Urine bilirubin decreased 18.50 9.95 9 196779 137 64301807
Klebsiella infection 18.50 9.95 85 196703 13196 64288748
Dilatation intrahepatic duct acquired 18.48 9.95 16 196772 678 64301266
Renal impairment 18.43 9.95 541 196247 134476 64167468
Injection site warmth 18.41 9.95 9 196779 13453 64288491
Blood pressure diastolic increased 18.40 9.95 5 196783 10747 64291197
Blood glucose increased 18.27 9.95 201 196587 97872 64204072
Monoclonal immunoglobulin increased 18.25 9.95 7 196781 57 64301887
Human herpesvirus 6 encephalitis 18.24 9.95 13 196775 413 64301531
Autoimmune thyroiditis 18.23 9.95 36 196752 3492 64298452
Sepsis syndrome 18.22 9.95 21 196767 1260 64300684
Poisoning 18.21 9.95 24 196764 21855 64280089
Haematochezia 18.20 9.95 123 196665 66250 64235694
Diabetic ketoacidosis 18.16 9.95 40 196748 29805 64272139
Polyomavirus viraemia 18.15 9.95 20 196768 1142 64300802
Lymphadenopathy 18.09 9.95 220 196568 46466 64255478
Abdominal pain 18.07 9.95 774 196014 311601 63990343
Myelodysplastic syndrome 18.06 9.95 145 196643 27434 64274510
Rhinitis allergic 18.03 9.95 60 196728 8018 64293926
Disseminated intravascular coagulation 17.99 9.95 164 196624 32184 64269760
Red blood cell elliptocytes present 17.93 9.95 9 196779 147 64301797
Product complaint 17.92 9.95 7 196781 11947 64289997
Light chain disease 17.90 9.95 10 196778 205 64301739
Haematopoietic stem cell mobilisation 17.86 9.95 10 196778 206 64301738
Lung infiltration 17.81 9.95 117 196671 20772 64281172
Coma 17.78 9.95 176 196612 87439 64214505
Device expulsion 17.78 9.95 23 196765 21113 64280831
Herpes zoster reactivation 17.78 9.95 8 196780 101 64301843
Death 17.71 9.95 1706 195082 480999 63820945
Urobilinogen urine increased 17.70 9.95 15 196773 617 64301327
Product substitution issue 17.70 9.95 17 196771 17844 64284100
Cellulitis enterococcal 17.64 9.95 6 196782 33 64301911
Capillary leak syndrome 17.47 9.95 34 196754 3263 64298681
Myelocyte count increased 17.37 9.95 16 196772 736 64301208
Pyogenic granuloma 17.37 9.95 13 196775 446 64301498
Withdrawal syndrome 17.36 9.95 28 196760 23464 64278480
Haemodialysis 17.30 9.95 100 196688 16977 64284967
Corneal deposits 17.29 9.95 12 196776 365 64301579
Septic embolus 17.28 9.95 24 196764 1738 64300206
White blood cells urine 17.26 9.95 12 196776 366 64301578
Lupus-like syndrome 17.25 9.95 3 196785 8788 64293156
Iron deficiency anaemia 17.22 9.95 25 196763 21864 64280080
Mean cell volume decreased 17.19 9.95 35 196753 3471 64298473
Hepatitis fulminant 17.15 9.95 50 196738 6224 64295720
Infusion site discomfort 17.12 9.95 16 196772 750 64301194
Nocardiosis 17.09 9.95 42 196746 4725 64297219
Product prescribing error 17.08 9.95 53 196735 35216 64266728
Marrow hyperplasia 16.91 9.95 21 196767 1363 64300581
Oroantral fistula 16.90 9.95 12 196776 379 64301565
Neuralgic amyotrophy 16.88 9.95 10 196778 230 64301714
Protein total increased 16.87 9.95 34 196754 3347 64298597
Escherichia infection 16.82 9.95 91 196697 15077 64286867
Atrial flutter 16.80 9.95 109 196679 19271 64282673
Injection site rash 16.77 9.95 14 196774 15728 64286216
Tumour flare 16.75 9.95 16 196772 771 64301173
Mucosal disorder 16.74 9.95 32 196756 3030 64298914
Acanthamoeba infection 16.71 9.95 13 196775 473 64301471
Sleep disorder 16.69 9.95 110 196678 59599 64242345
Renal tubular disorder 16.64 9.95 48 196740 5939 64296005
Atrioventricular block first degree 16.57 9.95 6 196782 10728 64291216
Pain in jaw 16.55 9.95 66 196722 40689 64261255
Myeloblast percentage decreased 16.55 9.95 6 196782 41 64301903
BK virus infection 16.50 9.95 55 196733 7357 64294587
Accessory spleen 16.49 9.95 9 196779 176 64301768
Delayed engraftment 16.42 9.95 10 196778 242 64301702
Dyslipidaemia 16.39 9.95 4 196784 9238 64292706
Hypouricaemia 16.38 9.95 12 196776 398 64301546
Infusion site extravasation 16.36 9.95 52 196736 6785 64295159
Splenic embolism 16.35 9.95 9 196779 179 64301765
Joint range of motion decreased 16.32 9.95 21 196767 19322 64282622
Arteriosclerosis coronary artery 16.32 9.95 14 196774 15515 64286429
Pregnancy 16.25 9.95 24 196764 20841 64281103
Coronary artery stenosis 16.19 9.95 7 196781 11241 64290703
Herpes simplex pneumonia 16.19 9.95 6 196782 44 64301900
Neutrophil morphology abnormal 16.17 9.95 7 196781 80 64301864
Flushing 16.10 9.95 333 196455 78315 64223629
Tenosynovitis 16.05 9.95 8 196780 11825 64290119
Neutropenic colitis 16.04 9.95 40 196748 4541 64297403
Meningitis bacterial 16.03 9.95 27 196761 2316 64299628
Pneumonia klebsiella 16.02 9.95 37 196751 4000 64297944
Bronchiolitis obliterans syndrome 16.00 9.95 10 196778 254 64301690
Peripheral sensory neuropathy 15.98 9.95 73 196715 11305 64290639
Rash papulosquamous 15.98 9.95 8 196780 130 64301814
Aphasia 15.95 9.95 193 196595 40713 64261231
Abdominal wall wound 15.94 9.95 7 196781 83 64301861
Cytomegalovirus gastroenteritis 15.90 9.95 12 196776 417 64301527
Abortion spontaneous 15.88 9.95 33 196755 25110 64276834
Dyspnoea exertional 15.86 9.95 146 196642 73584 64228360
Thyroxine free decreased 15.82 9.95 16 196772 827 64301117
Polyarthritis 15.74 9.95 5 196783 9710 64292234
Mean cell haemoglobin increased 15.74 9.95 32 196756 3170 64298774
Extrapyramidal disorder 15.71 9.95 22 196766 19530 64282414
Follicular mucinosis 15.61 9.95 5 196783 22 64301922
Thyroid stimulating immunoglobulin increased 15.58 9.95 7 196781 88 64301856
Transfusion reaction 15.57 9.95 22 196766 1619 64300325
Skin ulcer 15.56 9.95 75 196713 43899 64258045
Pneumonia parainfluenzae viral 15.52 9.95 10 196778 268 64301676
Klebsiella test positive 15.49 9.95 20 196768 1350 64300594
Sputum discoloured 15.47 9.95 19 196769 17837 64284107
Hypoglossal nerve paralysis 15.43 9.95 5 196783 23 64301921
Pseudomonal bacteraemia 15.33 9.95 26 196762 2243 64299701
Encephalitis brain stem 15.30 9.95 9 196779 204 64301740
Post procedural complication 15.27 9.95 26 196762 21327 64280617
Factor XIII Inhibition 15.26 9.95 5 196783 24 64301920
Gastroenteritis norovirus 15.17 9.95 29 196759 2746 64299198
Sciatica 15.12 9.95 24 196764 20240 64281704
Procedural pain 15.09 9.95 15 196773 15493 64286451
Palpitations 15.07 9.95 226 196562 104262 64197682
Full blood count increased 15.06 9.95 12 196776 452 64301492
Meningitis listeria 15.03 9.95 15 196773 763 64301181
Metastases to lymph nodes 15.02 9.95 4 196784 8713 64293231
Leukopenia 15.02 9.95 410 196378 100832 64201112
Adenoviral hepatitis 14.97 9.95 12 196776 456 64301488
Oesophagitis 14.87 9.95 115 196673 21515 64280429
Creatinine urine decreased 14.81 9.95 9 196779 217 64301727
Amyloidosis 14.81 9.95 27 196761 2467 64299477
Ear pruritus 14.79 9.95 28 196760 2632 64299312
Achromobacter infection 14.72 9.95 7 196781 101 64301843
Postural tremor 14.68 9.95 13 196775 568 64301376
Duodenal stenosis 14.67 9.95 14 196774 674 64301270
Hypertension 14.65 9.95 644 196144 258617 64043327
Blood immunoglobulin G decreased 14.62 9.95 28 196760 2655 64299289
Insomnia 14.62 9.95 741 196047 197095 64104849
Disseminated strongyloidiasis 14.60 9.95 7 196781 103 64301841
Right ventricular failure 14.58 9.95 27 196761 21444 64280500
Chronic lymphocytic leukaemia transformation 14.56 9.95 9 196779 224 64301720
Lung neoplasm malignant 14.54 9.95 27 196761 21421 64280523
Impaired work ability 14.49 9.95 15 196773 15204 64286740
Tooth deposit 14.49 9.95 9 196779 226 64301718
Haemophilus sepsis 14.48 9.95 5 196783 29 64301915
Autoimmune haemolytic anaemia 14.43 9.95 51 196737 7025 64294919
Sideroblastic anaemia 14.42 9.95 9 196779 228 64301716
Hyperpyrexia 14.40 9.95 41 196747 5036 64296908
Emphysema 14.40 9.95 13 196775 14056 64287888
Respiratory acidosis 14.40 9.95 6 196782 9849 64292095
Herpes simplex meningoencephalitis 14.40 9.95 6 196782 62 64301882
CSF lactate increased 14.39 9.95 3 196785 0 64301944
Frequent bowel movements 14.31 9.95 21 196767 18284 64283660
Chronic obstructive pulmonary disease 14.30 9.95 143 196645 70905 64231039
Reticulocytosis 14.28 9.95 12 196776 488 64301456
Stenotrophomonas infection 14.22 9.95 30 196758 3050 64298894
Urinary tract infection enterococcal 14.15 9.95 29 196759 2889 64299055
Brain herniation 14.12 9.95 48 196740 6485 64295459
Bone marrow failure 14.08 9.95 215 196573 47737 64254207
Productive cough 14.05 9.95 149 196639 73054 64228890
Coronary artery occlusion 14.02 9.95 13 196775 13878 64288066
Colitis 13.89 9.95 254 196534 58420 64243524
Accidental overdose 13.84 9.95 54 196734 33503 64268441
Poikiloderma 13.83 9.95 10 196778 325 64301619
Haemorrhage intracranial 13.75 9.95 122 196666 23762 64278182
Dry skin 13.74 9.95 226 196562 50935 64251009
Aspartate aminotransferase increased 13.72 9.95 470 196318 119318 64182626
Blood thyroid stimulating hormone abnormal 13.71 9.95 14 196774 732 64301212
Haematocrit increased 13.65 9.95 31 196757 3314 64298630
Panniculitis 13.64 9.95 5 196783 8874 64293070
Arteriosclerosis 13.64 9.95 17 196771 15860 64286084
Haemorrhagic disorder 13.64 9.95 19 196769 1380 64300564
CNS ventriculitis 13.62 9.95 10 196778 333 64301611
Emotional distress 13.62 9.95 60 196728 35978 64265966
Meningoencephalitis bacterial 13.62 9.95 8 196780 181 64301763
Colitis microscopic 13.61 9.95 3 196785 7429 64294515
Haematoma 13.55 9.95 84 196704 46166 64255778
Granulocyte percentage 13.53 9.95 6 196782 73 64301871
Rash papular 13.49 9.95 94 196694 17019 64284925
Dysgeusia 13.45 9.95 210 196578 46837 64255107
Anti-thyroid antibody 13.45 9.95 5 196783 37 64301907
Pulmonary haemorrhage 13.44 9.95 77 196711 13032 64288912
Psychotic disorder 13.41 9.95 57 196731 34521 64267423
Human chorionic gonadotropin increased 13.41 9.95 15 196773 871 64301073
Device breakage 13.34 9.95 5 196783 8750 64293194
Immunodeficiency common variable 13.31 9.95 9 196779 262 64301682
Adenomatous polyposis coli 13.31 9.95 8 196780 189 64301755
Avulsion fracture 13.25 9.95 9 196779 264 64301680
Model for end stage liver disease score increased 13.21 9.95 4 196784 14 64301930
Encephalomyelitis 13.20 9.95 8 196780 192 64301752
Pneumococcal sepsis 13.15 9.95 18 196770 1286 64300658
Candida sepsis 13.07 9.95 24 196764 2204 64299740
Fumbling 13.05 9.95 7 196781 132 64301812
Hepatic encephalopathy 13.01 9.95 28 196760 21038 64280906
Tri-iodothyronine free abnormal 13.01 9.95 5 196783 41 64301903
Metapneumovirus infection 13.01 9.95 19 196769 1442 64300502
Immunosuppression 12.97 9.95 66 196722 10680 64291264
Haematemesis 12.93 9.95 87 196701 46912 64255032
Ear swelling 12.93 9.95 18 196770 1307 64300637
Babesiosis 12.85 9.95 9 196779 278 64301666
Brain oedema 12.83 9.95 113 196675 21962 64279982
Haemorrhage 12.73 9.95 168 196620 79183 64222761
Glomerulonephritis minimal lesion 12.73 9.95 13 196775 680 64301264
Pallor 12.66 9.95 68 196720 38713 64263231
Actinomycosis 12.66 9.95 15 196773 927 64301017
Body temperature increased 12.60 9.95 169 196619 36497 64265447
Drug tolerance decreased 12.47 9.95 3 196785 6995 64294949
Peripheral arterial occlusive disease 12.44 9.95 3 196785 6984 64294960
Exostosis 12.40 9.95 10 196778 11428 64290516
Coombs direct test positive 12.39 9.95 10 196778 384 64301560
Pneumonia pseudomonal 12.39 9.95 38 196750 4865 64297079
Glomerulosclerosis 12.37 9.95 15 196773 950 64300994
Obliterative bronchiolitis 12.36 9.95 26 196762 2639 64299305
CSF test abnormal 12.35 9.95 11 196777 484 64301460
Disturbance in attention 12.34 9.95 74 196714 41000 64260944
Altered state of consciousness 12.33 9.95 173 196615 37729 64264215
Thunderclap headache 12.30 9.95 8 196780 218 64301726
Hypophosphataemia 12.28 9.95 82 196706 14638 64287306
Cytomegalovirus hepatitis 12.28 9.95 12 196776 595 64301349
Hepatosplenomegaly 12.21 9.95 40 196748 5303 64296641
Femur fracture 12.20 9.95 58 196730 34077 64267867
Asphyxia 12.19 9.95 7 196781 9559 64292385
Injection site induration 12.17 9.95 6 196782 8926 64293018
Ventricular fibrillation 12.17 9.95 35 196753 23825 64278119
Injection site discolouration 12.14 9.95 3 196785 6872 64295072
Rash macular 12.13 9.95 118 196670 23567 64278377
JC virus CSF test positive 12.13 9.95 7 196781 153 64301791
Forced expiratory volume decreased 12.12 9.95 3 196785 6864 64295080
Alveolitis necrotising 12.08 9.95 4 196784 20 64301924
Caesarean section 12.05 9.95 10 196778 11264 64290680
Fibromyalgia 12.03 9.95 62 196726 35669 64266275
Periorbital swelling 12.02 9.95 21 196767 1855 64300089
Gastrointestinal candidiasis 12.02 9.95 9 196779 309 64301635
Norovirus infection 11.98 9.95 8 196780 228 64301716
Osteopenia 11.98 9.95 18 196770 15522 64286422
Corneal graft rejection 11.97 9.95 5 196783 52 64301892
Retinal depigmentation 11.92 9.95 9 196779 313 64301631
Oesophageal irritation 11.90 9.95 6 196782 99 64301845
Oesophagopleural fistula 11.88 9.95 5 196783 53 64301891
Genital herpes 11.87 9.95 21 196767 1874 64300070
Metastases to central nervous system 11.85 9.95 15 196773 13897 64288047
Vitamin B1 decreased 11.84 9.95 9 196779 316 64301628
Immature granulocyte percentage increased 11.80 9.95 5 196783 54 64301890
CSF cell count increased 11.79 9.95 6 196782 101 64301843
Lymphocyte count abnormal 11.79 9.95 14 196774 867 64301077
Cystitis viral 11.77 9.95 12 196776 626 64301318
Product storage error 11.72 9.95 14 196774 13304 64288640
Retinitis viral 11.69 9.95 6 196782 103 64301841
Corneal lesion 11.64 9.95 5 196783 56 64301888
Immune system disorder 11.64 9.95 57 196731 9084 64292860
Polyp 11.62 9.95 3 196785 6670 64295274
Fibrous histiocytoma 11.55 9.95 11 196777 528 64301416
Leukaemia 11.54 9.95 38 196750 5050 64296894
Atypical pneumonia 11.53 9.95 39 196749 5255 64296689
Fracture 11.52 9.95 25 196763 18730 64283214
Ovarian cyst 11.49 9.95 10 196778 11008 64290936
Adenovirus reactivation 11.45 9.95 8 196780 246 64301698
Anhedonia 11.44 9.95 15 196773 13691 64288253
Tonsillar haemorrhage 11.42 9.95 8 196780 247 64301697
Monocyte percentage decreased 11.39 9.95 8 196780 248 64301696
Blood immunoglobulin A increased 11.38 9.95 11 196777 538 64301406
Neurosyphilis 11.33 9.95 4 196784 25 64301919
Nightmare 11.30 9.95 30 196758 20963 64280981
Refractoriness to platelet transfusion 11.29 9.95 6 196782 111 64301833
Immunosuppressant drug level increased 11.28 9.95 48 196740 7211 64294733
Renal tubular necrosis 11.25 9.95 110 196678 22000 64279944
Product dispensing error 11.22 9.95 11 196777 11439 64290505
Eye infection fungal 11.21 9.95 10 196778 441 64301503
Endotoxic shock 11.20 9.95 4 196784 26 64301918
Vulvovaginal injury 11.20 9.95 8 196780 255 64301689
Peritonitis 11.15 9.95 39 196749 24984 64276960
Infusion site scar 11.15 9.95 8 196780 257 64301687
Cerebral toxoplasmosis 11.13 9.95 20 196768 1806 64300138
Product administration error 11.08 9.95 45 196743 27598 64274346
Eosinophil percentage decreased 11.01 9.95 8 196780 262 64301682
Therapeutic response unexpected 11.00 9.95 22 196766 16979 64284965
Prescribed overdose 10.98 9.95 29 196759 20302 64281642
Product use in unapproved indication 10.96 9.95 651 196137 175967 64125977
Glomerulonephritis chronic 10.96 9.95 8 196780 264 64301680
Pulmonary sepsis 10.92 9.95 27 196761 3048 64298896
Gastritis fungal 10.92 9.95 7 196781 186 64301758
Angina unstable 10.91 9.95 19 196769 15448 64286496
Respiratory tract infection fungal 10.90 9.95 15 196773 1077 64300867
Asterixis 10.89 9.95 23 196765 2340 64299604
Pneumonitis 10.89 9.95 215 196573 50150 64251794
Swelling of eyelid 10.89 9.95 22 196766 2170 64299774
Faeces discoloured 10.87 9.95 41 196747 25688 64276256
Paternal exposure timing unspecified 10.85 9.95 5 196783 67 64301877
Phyllodes tumour 10.83 9.95 4 196784 29 64301915
Pulmonary hypertension 10.82 9.95 82 196706 43057 64258887
Eosinophil count increased 10.82 9.95 77 196711 14035 64287909
Viral oesophagitis 10.80 9.95 3 196785 7 64301937
Hyperplasia 10.77 9.95 15 196773 1089 64300855
Genital tract inflammation 10.71 9.95 4 196784 30 64301914
Oral viral infection 10.71 9.95 4 196784 30 64301914
Social problem 10.69 9.95 16 196772 1241 64300703
Liver function test 10.61 9.95 6 196782 126 64301818
Mean platelet volume decreased 10.61 9.95 19 196769 1712 64300232
SARS-CoV-2 RNA 10.60 9.95 4 196784 31 64301913
Rhinovirus infection 10.58 9.95 42 196746 6114 64295830
Immature granulocyte count increased 10.57 9.95 10 196778 476 64301468
Haemoglobin urine 10.57 9.95 6 196782 127 64301817
Premature labour 10.57 9.95 5 196783 7615 64294329
Oedema peripheral 10.56 9.95 529 196259 209788 64092156
Road traffic accident 10.55 9.95 53 196735 30692 64271252
Campylobacter infection 10.53 9.95 16 196772 1258 64300686
Tremor 10.50 9.95 553 196235 147677 64154267
Pneumonia aspiration 10.44 9.95 123 196665 59148 64242796
Bone density decreased 10.42 9.95 9 196779 9943 64292001
Systemic inflammatory response syndrome 10.41 9.95 60 196728 10175 64291769
Shock 10.41 9.95 71 196717 38169 64263775
Cerebrovascular accident 10.39 9.95 330 196458 137253 64164691
Blood glucose decreased 10.33 9.95 36 196752 23087 64278857
Chronic graft versus host disease in intestine 10.33 9.95 8 196780 289 64301655
Urine bilirubin increased 10.32 9.95 6 196782 133 64301811
Ketoacidosis 10.32 9.95 4 196784 6859 64295085
Complications of transplant surgery 10.32 9.95 12 196776 727 64301217
Renal cyst 10.25 9.95 14 196774 12556 64289388
Brain abscess 10.19 9.95 32 196756 4149 64297795
Nodule 10.16 9.95 25 196763 17922 64284022
Adenoviral haemorrhagic cystitis 10.14 9.95 10 196778 501 64301443
Glycosylated haemoglobin increased 10.14 9.95 21 196767 15998 64285946
CSF oligoclonal band present 10.13 9.95 6 196782 138 64301806
Glucose urine present 10.11 9.95 18 196770 1614 64300330
Drug tolerance 10.10 9.95 3 196785 6082 64295862
White blood cell disorder 10.10 9.95 24 196764 2643 64299301
Cataract subcapsular 10.09 9.95 13 196775 876 64301068
Hyperhidrosis 10.08 9.95 297 196491 124623 64177321
Hypoaesthesia 10.06 9.95 520 196268 138588 64163356
Pemphigoid 10.05 9.95 15 196773 12971 64288973
Respiratory rate increased 10.02 9.95 26 196762 18305 64283639
Tardive dyskinesia 9.98 9.95 8 196780 9170 64292774
Menstruation irregular 9.95 9.95 33 196755 4402 64297542

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D06BB03 DERMATOLOGICALS
ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
CHEMOTHERAPEUTICS FOR TOPICAL USE
Antivirals
ATC D06BB53 DERMATOLOGICALS
ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
CHEMOTHERAPEUTICS FOR TOPICAL USE
Antivirals
ATC J05AB01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIVIRALS FOR SYSTEMIC USE
DIRECT ACTING ANTIVIRALS
Nucleosides and nucleotides excl. reverse transcriptase inhibitors
ATC S01AD03 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Antivirals
FDA MoA N0000020060 DNA Polymerase Inhibitors
FDA EXT N0000175459 Nucleoside Analog
FDA EPC N0000175468 Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor
CHEBI has role CHEBI:35221 antimetabolite
CHEBI has role CHEBI:36044 antiviral drugs
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000998 Antiviral Agents
FDA EPC N0000180187 Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor
FDA EPC N0000180188 Herpes Zoster Virus Nucleoside Analog DNA Polymerase Inhibitor

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Herpes labialis indication 1475003
Herpes zoster indication 4740000 DOID:8536
Genital herpes simplex indication 33839006 DOID:8704
Varicella indication 38907003 DOID:8659
Herpes simplex indication 88594005 DOID:8566
Herpes simplex infection of skin indication 240475000
Recurrent herpes simplex labialis indication 402892009
Recurrent genital herpes simplex indication 402894005
Encephalitis due to Herpesvirus indication 428638009
Recurrent Mucocutaneous Herpes Simplex indication
Suppression of Recurrent Herpes Simplex Infection indication
Herpes zoster ophthalmicus off-label use 87513003
Granulomatosis Infantiseptica off-label use
Herpes Zoster Hepatitis off-label use
Neonatal Herpes Meningoencephalitis off-label use
Disseminated Herpes Simplex Neonatal Infection off-label use
Herpes Simplex Hepatitis off-label use
Prevention of Herpes Zoster in Immunocompromised Patient off-label use
Urinary tract obstruction contraindication 7163005 DOID:5200
Hypercholesterolemia contraindication 13644009
Myocardial infarction contraindication 22298006 DOID:5844
Dehydration contraindication 34095006
Hypertensive disorder contraindication 38341003 DOID:10763
Diabetes mellitus contraindication 73211009 DOID:9351
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Hyperglycemia contraindication 80394007 DOID:4195
Kidney disease contraindication 90708001 DOID:557
Hemolytic uremic syndrome contraindication 111407006 DOID:12554
Impaired renal function disorder contraindication 197663003
Cerebrovascular accident contraindication 230690007
Telangiectasia disorder contraindication 247479008
Pregnancy, function contraindication 289908002
Osteopenia contraindication 312894000
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Cardiovascular event risk contraindication 395112001
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006
Breastfeeding (mother) contraindication 413712001
Obesity contraindication 414916001 DOID:9970
Smokes tobacco daily contraindication 449868002
Vertebral Metastases contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.97 acidic
pKa2 13.01 acidic
pKa3 3.83 Basic
pKa4 2.12 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
5%;1% XERESE BAUSCH N022436 July 31, 2009 RX CREAM TOPICAL 7223387 Nov. 13, 2022 COMBINATION PRODUCT FOR THE EARLY TREATMENT OF RECURRENT HERPES LABIALIS (COLD SORES) TO REDUCE THE LIKELIHOOD OF ULCERATIVE COLD SORES AND TO SHORTEN THE LESION HEALING TIME IN ADULTS AND CHILDREN (6 YEARS OF AGE AND OLDER)
5%;1% XERESE BAUSCH N022436 July 31, 2009 RX CREAM TOPICAL 7223387 Nov. 13, 2022 NEW COMBINATION PRODUCT FOR THE EARLY TREATMENT OF RECURRENT HERPES LABIALIS (COLD SORES) TO REDUCE THE LIKELIHOOD OF ULCERATIVE COLD SORES AND TO SHORTEN THE LESION HEALING TIME IN ADULTS AND ADOLESCENTS (12 YEARS OF AGE AND OLDER)
50MG SITAVIG EPI HLTH N203791 April 12, 2013 RX TABLET BUCCAL 8791127 March 23, 2027 TREATMENT OF HERPES LABIALIS
50MG SITAVIG EPI HLTH N203791 April 12, 2013 RX TABLET BUCCAL 8747896 June 3, 2027 TREATMENT OF HERPES LABIALIS
50MG SITAVIG EPI HLTH N203791 April 12, 2013 RX TABLET BUCCAL 8592434 June 16, 2030 TREATMENT OF HERPES LABIALIS

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
3% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** AVACLYR FERA PHARMS LLC N202408 March 29, 2019 DISCN OINTMENT OPHTHALMIC March 29, 2026 INDICATED FOR THE TREATMENT OF ACUTE HERPETIC KERATITIS (DENDRITIC ULCERS) IN PATIENTS WITH HERPES SIMPLEX (HSV-1 AND HSV-2) VIRUS

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Purine nucleoside phosphorylase Enzyme Ki 4.04 CHEMBL
DNA polymerase catalytic subunit Enzyme INHIBITOR DRUG LABEL DRUG LABEL
DNA polymerase catalytic subunit Enzyme INHIBITOR WOMBAT-PK DRUG LABEL
Thymidine kinase Kinase INHIBITOR WOMBAT-PK DRUG LABEL
Thymidine kinase Kinase INHIBITOR WOMBAT-PK DRUG LABEL
Thymidine kinase Kinase WOMBAT-PK
Purine nucleoside phosphorylase Enzyme Kd 4.90 CHEMBL

External reference:

IDSource
4018781 VUID
N0000147084 NUI
D00222 KEGG_DRUG
69657-51-8 SECONDARY_CAS_RN
152535 RXNORM
C0001367 UMLSCUI
CHEBI:2453 CHEBI
AC2 PDB_CHEM_ID
CHEMBL1200380 ChEMBL_ID
CHEMBL184 ChEMBL_ID
DB00787 DRUGBANK_ID
D000212 MESH_DESCRIPTOR_UI
135398513 PUBCHEM_CID
4435 INN_ID
4829 IUPHAR_LIGAND_ID
X4HES1O11F UNII
14023 MMSL
1579 MMSL
4132 MMSL
4133 MMSL
981 MMSL
d00001 MMSL
003016 NDDF
003017 NDDF
4018781 VANDF
4018782 VANDF
372729009 SNOMEDCT_US
41193000 SNOMEDCT_US
72387009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0093-3630 CREAM 50 mg TOPICAL NDA authorized generic 26 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0143-9657 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 500 mg INTRAVENOUS ANDA 23 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0143-9658 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 g INTRAVENOUS ANDA 23 sections
acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0168-0825 OINTMENT 50 mg TOPICAL ANDA 22 sections
Zovirax HUMAN PRESCRIPTION DRUG LABEL 1 0187-0993 OINTMENT 50 mg TOPICAL NDA 21 sections
Zovirax HUMAN PRESCRIPTION DRUG LABEL 1 0187-0994 CREAM 50 mg TOPICAL NDA 26 sections
Xerese HUMAN PRESCRIPTION DRUG LABEL 2 0187-5104 CREAM 50 mg TOPICAL NDA 26 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0378-8700 OINTMENT 50 mg TOPICAL ANDA 20 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0378-8712 SUSPENSION 200 mg ORAL NDA authorized generic 20 sections
Zovirax HUMAN PRESCRIPTION DRUG LABEL 1 0378-9735 SUSPENSION 200 mg ORAL NDA 20 sections
acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0440-7033 TABLET 800 mg ORAL ANDA 22 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0472-0082 SUSPENSION 200 mg ORAL ANDA 19 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0591-1159 OINTMENT 50 mg TOPICAL NDA authorized generic 22 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0713-0630 OINTMENT 50 mg TOPICAL ANDA 19 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0713-0630 OINTMENT 50 mg TOPICAL ANDA 19 sections
ACYCLOVIR HUMAN PRESCRIPTION DRUG LABEL 1 0904-5789 CAPSULE 200 mg ORAL ANDA 21 sections
acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0904-5790 TABLET 400 mg ORAL ANDA 22 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 10544-039 TABLET 400 mg ORAL ANDA 20 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 10544-089 CAPSULE 200 mg ORAL ANDA 20 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 10544-101 CAPSULE 200 mg ORAL ANDA 22 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 10544-102 TABLET 400 mg ORAL ANDA 22 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 10544-103 TABLET 800 mg ORAL ANDA 22 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 12634-520 TABLET 400 mg ORAL ANDA 22 sections
acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 12634-697 TABLET 800 mg ORAL ANDA 22 sections
acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 13668-515 OINTMENT 50 mg TOPICAL ANDA 16 sections
acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 13668-515 OINTMENT 50 mg TOPICAL ANDA 16 sections
ACYCLOVIR HUMAN PRESCRIPTION DRUG LABEL 1 16590-003 TABLET 800 mg ORAL ANDA 18 sections
ACYCLOVIR HUMAN PRESCRIPTION DRUG LABEL 1 16590-370 TABLET 400 mg ORAL ANDA 18 sections
acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 16714-885 OINTMENT 50 mg TOPICAL ANDA 19 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 17856-0083 SUSPENSION 200 mg ORAL ANDA 19 sections