Dihydroorotate dehydrogenase (quinone), mitochondrial
Description:
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Drug Relations:
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leflunomide
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An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS. | Bioactivity details | MOA |
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teriflunomide
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Teriflunomide, an immunomodulatory agent with anti-inflammatory properties, inhibits dihydroorotate dehydrogenase, a mitochondrial enzyme involved in de novo pyrimidine synthesis. The exact mechanism by which teriflunomide exerts its therapeutic effect in multiple sclerosis is unknown but may involve a reduction in the number of activated lymphocytes in CNS. | Bioactivity details | MOA |
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atovaquone
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A hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols. | Bioactivity details | MOA |
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ciclosporin
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A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed). | Bioactivity details | MOA |
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clonixin
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Anti-inflammatory analgesic. | Bioactivity details | MOA |
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flunixin
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Bioactivity details | MOA |
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niflumic acid
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An analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis. | Bioactivity details | MOA |
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oxycinchophen
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Bioactivity details | MOA |
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