leflunomide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1552 75706-12-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • leflunomide medac
  • leflunomide
  • arava
  • avara
  • leflunomida
  • leflunomidum
  • lefumide
  • repso
An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
  • Molecular weight: 270.21
  • Formula: C12H9F3N2O2
  • CLOGP: 2.36
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 55.13
  • ALOGS: -3.51
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.02 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.23 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 80 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
fu (Fraction unbound in plasma) 0.00 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Approvals:

DateAgencyCompanyOrphan
Sept. 2, 1999 EMA Sanofi-aventis Deutschland GmbH
Sept. 10, 1998 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 6652.86 14.64 18828 417845 1025937 62026412
Drug intolerance 5071.13 14.64 8218 428455 300443 62751906
Contraindicated product administered 4291.84 14.64 6310 430363 211338 62841011
Joint swelling 3787.29 14.64 7487 429186 320179 62732170
Rheumatoid arthritis 3725.76 14.64 6431 430242 247388 62804961
Synovitis 3113.05 14.64 5015 431658 181903 62870446
Treatment failure 3022.84 14.64 5123 431550 193920 62858429
Arthropathy 2745.07 14.64 5396 431277 229396 62822953
Therapeutic product effect decreased 2494.84 14.64 4633 432040 188554 62863795
Pemphigus 2378.22 14.64 4411 432262 179315 62873034
Systemic lupus erythematosus 2196.10 14.64 4596 432077 204322 62848027
Abdominal discomfort 2059.19 14.64 5834 430839 315051 62737298
Swelling 2038.34 14.64 5278 431395 270100 62782249
Glossodynia 1967.15 14.64 4010 432663 174866 62877483
Hand deformity 1957.75 14.64 3744 432929 155713 62896636
Alopecia 1896.26 14.64 5854 430819 331682 62720667
Pain 1584.42 14.64 9574 427099 731054 62321295
Death 1530.18 14.64 351 436322 374030 62678319
Hepatic enzyme increased 1397.42 14.64 3782 432891 198546 62853803
Arthralgia 1301.07 14.64 7498 429175 562212 62490137
Anti-cyclic citrullinated peptide antibody positive 1273.36 14.64 2603 434070 113609 62938740
Wound 1241.33 14.64 3164 433509 160099 62892250
Hypersensitivity 1131.18 14.64 4489 432184 288196 62764153
Rheumatoid factor positive 1111.80 14.64 2044 434629 82362 62969987
Acute kidney injury 1065.44 14.64 252 436421 263163 62789186
Pericarditis 1033.18 14.64 2582 434091 128997 62923352
Hypotension 1031.71 14.64 298 436375 272306 62780043
Peripheral swelling 1020.11 14.64 4070 432603 261872 62790477
Musculoskeletal stiffness 1012.40 14.64 3179 433494 181439 62870910
Drug hypersensitivity 938.97 14.64 4425 432248 306262 62746087
Constipation 929.87 14.64 205 436468 224738 62827611
Toxicity to various agents 926.87 14.64 275 436398 246975 62805374
Therapeutic product effect incomplete 918.40 14.64 2393 434280 122663 62929686
Discomfort 916.50 14.64 2881 433792 164493 62887856
Rash 910.35 14.64 6779 429894 554092 62498257
Completed suicide 908.70 14.64 19 436654 145654 62906695
C-reactive protein abnormal 908.25 14.64 1339 435334 44757 63007592
Drug interaction 807.19 14.64 284 436389 228847 62823502
Anaemia 794.23 14.64 521 436152 292909 62759440
Folliculitis 776.68 14.64 1581 435092 68736 62983613
Muscle injury 767.01 14.64 1507 435166 63838 62988511
Psoriatic arthropathy 742.36 14.64 1819 434854 89701 62962648
Infection 734.39 14.64 3322 433351 225851 62826498
Product use issue 731.00 14.64 3229 433444 217291 62835058
Impaired healing 725.97 14.64 1936 434737 100606 62951743
Irritable bowel syndrome 713.57 14.64 1680 434993 80732 62971617
Gastrointestinal disorder 712.52 14.64 2253 434420 128986 62923363
Infusion related reaction 704.87 14.64 3447 433226 242074 62810275
Helicobacter infection 704.13 14.64 1798 434875 90987 62961362
Febrile neutropenia 696.41 14.64 27 436646 118422 62933927
Lower respiratory tract infection 683.48 14.64 2233 434440 130074 62922275
Duodenal ulcer perforation 676.38 14.64 1704 434969 85505 62966844
Dehydration 643.57 14.64 196 436477 173158 62879191
Ill-defined disorder 637.73 14.64 1601 435072 80154 62972195
Red blood cell sedimentation rate abnormal 636.20 14.64 732 435941 19050 63033299
Loss of personal independence in daily activities 616.42 14.64 1764 434909 95526 62956823
Hyponatraemia 575.42 14.64 53 436620 111847 62940502
Blister 574.38 14.64 2081 434592 127733 62924616
Red blood cell sedimentation rate increased 573.58 14.64 1061 435612 42921 63009428
Tremor 572.14 14.64 108 436565 132131 62920218
Product dose omission issue 567.65 14.64 467 436206 233846 62818503
Condition aggravated 560.17 14.64 4697 431976 397520 62654829
Seizure 555.69 14.64 117 436556 132517 62919832
Sleep disorder due to general medical condition, insomnia type 544.73 14.64 1147 435526 51070 63001279
Maternal exposure during pregnancy 532.57 14.64 2947 433726 217115 62835234
Somnolence 529.96 14.64 284 436389 178401 62873948
Fall 514.09 14.64 1218 435455 391116 62661233
C-reactive protein increased 501.12 14.64 1612 435061 93095 62959254
Disease progression 488.85 14.64 121 436552 122637 62929712
Intentional overdose 473.28 14.64 7 436666 74145 62978204
Overdose 462.98 14.64 111 436562 114967 62937382
Cardiac arrest 454.66 14.64 52 436621 92493 62959856
Anxiety 450.42 14.64 499 436174 217042 62835307
Urinary tract infection 445.26 14.64 708 435965 263976 62788373
Dizziness 444.80 14.64 1495 435178 428430 62623919
Bradycardia 436.22 14.64 15 436658 73212 62979137
Mobility decreased 430.70 14.64 1813 434860 119346 62933003
Thrombocytopenia 424.18 14.64 257 436416 150900 62901449
Bone erosion 416.13 14.64 560 436113 17157 63035192
Dyspnoea 414.89 14.64 2757 433916 658556 62393793
Knee arthroplasty 406.42 14.64 1046 435627 53160 62999189
Rheumatoid nodule 404.09 14.64 543 436130 16612 63035737
Neutropenia 387.48 14.64 379 436294 174626 62877723
Hypokalaemia 380.36 14.64 120 436553 103684 62948665
Electrocardiogram QT prolonged 366.27 14.64 9 436664 59521 62992828
Sepsis 361.02 14.64 313 436360 152810 62899539
Tachycardia 354.33 14.64 185 436488 117971 62934378
Blood iron abnormal 347.55 14.64 255 436418 3621 63048728
Chest discomfort 346.68 14.64 161 436512 109808 62942541
Hip arthroplasty 344.44 14.64 907 435766 46739 63005610
Stomatitis 340.03 14.64 1865 434808 136860 62915489
Depressed level of consciousness 331.21 14.64 25 436648 62053 62990296
Vision blurred 326.71 14.64 112 436561 91812 62960537
Suicide attempt 326.53 14.64 24 436649 60894 62991455
Blood cholesterol increased 320.11 14.64 1389 435284 92643 62959706
Balance disorder 319.43 14.64 92 436581 84330 62968019
Platelet count decreased 304.56 14.64 213 436460 115909 62936440
Rheumatic fever 303.84 14.64 813 435860 42298 63010051
Abdominal pain 303.38 14.64 1020 435653 292436 62759913
Oedema peripheral 301.72 14.64 525 436148 188986 62863363
Osteoarthritis 300.91 14.64 1377 435296 93966 62958383
Foot deformity 292.92 14.64 614 436059 27239 63025110
Hyperkalaemia 291.54 14.64 21 436652 54182 62998167
Pulmonary embolism 288.00 14.64 228 436445 116456 62935893
Atrial fibrillation 285.25 14.64 230 436443 116406 62935943
Inflammation 285.16 14.64 1222 435451 81051 62971298
Swollen joint count increased 281.94 14.64 707 435966 35347 63017002
Respiratory failure 281.76 14.64 176 436497 101682 62950667
Cough 272.50 14.64 1063 435610 291680 62760669
Cardio-respiratory arrest 272.34 14.64 43 436630 59916 62992433
Hallucination 271.23 14.64 30 436643 54787 62997562
Cerebrovascular accident 270.50 14.64 208 436465 107816 62944533
Sinusitis 270.38 14.64 2561 434112 224092 62828257
Agitation 266.62 14.64 45 436628 59712 62992637
Neutrophil count decreased 266.51 14.64 36 436637 56370 62995979
Hypoglycaemia 261.95 14.64 48 436625 60017 62992332
Asthenia 259.98 14.64 1560 435113 382044 62670305
Epistaxis 259.48 14.64 88 436585 72637 62979712
Muscle spasms 257.34 14.64 423 436250 155727 62896622
Cognitive disorder 255.84 14.64 39 436634 55776 62996573
COVID-19 254.84 14.64 241 436432 112862 62939487
Deformity 251.34 14.64 354 436319 11330 63041019
Gastrointestinal haemorrhage 250.99 14.64 122 436551 81054 62971295
Fibromyalgia 247.46 14.64 1153 435520 79267 62973082
Tenosynovitis 246.42 14.64 383 436290 13412 63038937
Sedation 246.20 14.64 4 436669 38805 63013544
Hypoxia 245.74 14.64 55 436618 59737 62992612
Osteoporosis 243.91 14.64 908 435765 56430 62995919
Metabolic acidosis 243.72 14.64 17 436656 45052 63007297
Cardiac failure congestive 243.09 14.64 169 436504 92264 62960085
Chest pain 241.02 14.64 725 435948 215234 62837115
Blood glucose increased 239.66 14.64 139 436534 83617 62968732
Haemoglobin decreased 238.90 14.64 395 436278 145090 62907259
Drug tolerance decreased 235.91 14.64 428 436245 17045 63035304
Arthritis 234.56 14.64 1482 435191 114439 62937910
Musculoskeletal disorder 233.50 14.64 469 436204 20175 63032174
Wrong technique in product usage process 232.05 14.64 70 436603 62270 62990079
Pulmonary fibrosis 231.08 14.64 700 435973 39109 63013240
Syncope 229.06 14.64 282 436391 117103 62935246
Hyperhidrosis 227.82 14.64 243 436430 107593 62944756
Cardiac failure 225.27 14.64 170 436503 88972 62963377
Myalgia 224.12 14.64 416 436257 146113 62906236
Joint range of motion decreased 220.93 14.64 604 436069 31824 63020525
Pancytopenia 219.00 14.64 206 436467 96727 62955622
Lactic acidosis 217.48 14.64 11 436662 38276 63014073
Dysphagia 216.19 14.64 175 436498 88410 62963939
Renal failure 215.82 14.64 296 436377 117356 62934993
Flushing 212.87 14.64 126 436547 74961 62977388
Unresponsive to stimuli 212.39 14.64 4 436669 33812 63018537
Feeling abnormal 209.12 14.64 442 436231 147950 62904399
Disability 206.53 14.64 416 436257 17931 63034418
Bone pain 205.85 14.64 60 436613 54581 62997768
Chills 205.21 14.64 288 436385 113090 62939259
Plasma cell myeloma 204.95 14.64 10 436663 35895 63016454
Granuloma skin 204.74 14.64 271 436402 8166 63044183
Coma 204.73 14.64 93 436580 64271 62988078
Nausea 201.62 14.64 4415 432258 850056 62202293
White blood cell count decreased 200.51 14.64 409 436264 138695 62913654
Mental status changes 200.20 14.64 20 436653 39579 63012770
Blood parathyroid hormone decreased 199.37 14.64 289 436384 9502 63042847
Pneumonia aspiration 199.17 14.64 9 436664 34531 63017818
Adverse event 198.64 14.64 956 435717 66603 62985746
Joint stiffness 198.48 14.64 687 435986 41182 63011167
International normalised ratio increased 198.40 14.64 39 436634 46386 63005963
Panniculitis 197.67 14.64 312 436361 11073 63041276
Neuropathy peripheral 194.72 14.64 300 436373 113367 62938982
Pleural effusion 193.60 14.64 213 436460 92997 62959352
Liver injury 192.30 14.64 876 435797 59644 62992705
Therapeutic response decreased 192.13 14.64 886 435787 60639 62991710
Lethargy 190.90 14.64 73 436600 55934 62996415
Pulmonary oedema 187.90 14.64 71 436602 54802 62997547
Respiratory arrest 186.63 14.64 9 436664 32636 63019713
Gastrooesophageal reflux disease 186.32 14.64 230 436443 95409 62956940
Deep vein thrombosis 184.75 14.64 182 436491 83618 62968731
Hyperglycaemia 183.55 14.64 33 436640 41834 63010515
Blood pressure decreased 181.67 14.64 111 436562 64911 62987438
Vomiting 181.62 14.64 2733 433940 556884 62495465
Encephalopathy 181.61 14.64 25 436648 38595 63013754
Deafness transitory 177.52 14.64 130 436543 1840 63050509
Rhabdomyolysis 177.47 14.64 42 436631 43909 63008440
Grip strength decreased 176.29 14.64 439 436234 21848 63030501
Finger deformity 176.08 14.64 241 436432 7504 63044845
Nasopharyngitis 174.44 14.64 2584 434089 251673 62800676
Disturbance in attention 174.30 14.64 27 436646 38162 63014187
Orthostatic hypotension 173.41 14.64 22 436651 36138 63016211
Fluid retention 167.99 14.64 101 436572 59585 62992764
Asthma 165.81 14.64 397 436276 127164 62925185
Type 2 diabetes mellitus 164.70 14.64 871 435802 62997 62989352
Intentional product misuse 164.68 14.64 108 436565 60809 62991540
Dysarthria 164.41 14.64 45 436628 42666 63009683
Adverse drug reaction 164.23 14.64 1024 435649 78690 62973659
Restlessness 162.53 14.64 10 436663 29443 63022906
Ascites 162.34 14.64 40 436633 40688 63011661
Intentional self-injury 161.48 14.64 3 436670 25684 63026665
Diarrhoea 161.39 14.64 3721 432952 711645 62340704
Decreased appetite 157.95 14.64 1044 435629 250008 62802341
Drug withdrawal syndrome 157.08 14.64 7 436666 27187 63025162
Premature delivery 156.52 14.64 14 436659 30267 63022082
Dry skin 156.31 14.64 99 436574 56788 62995561
Palpitations 154.61 14.64 341 436332 112429 62939920
Depression 154.39 14.64 760 435913 195732 62856617
Rectal haemorrhage 154.13 14.64 72 436601 48958 63003391
Urinary retention 153.98 14.64 15 436658 30286 63022063
Dysgeusia 152.48 14.64 65 436608 46645 63005704
Liver function test increased 150.00 14.64 532 436141 32279 63020070
Pneumonia 150.00 14.64 2225 434448 454542 62597807
Hypervolaemia 149.98 14.64 12 436661 28401 63023948
Injection site pain 149.61 14.64 429 436244 129371 62922978
Full blood count decreased 149.34 14.64 7 436666 26017 63026332
Skin ulcer 148.04 14.64 638 436035 42407 63009942
Disorientation 145.55 14.64 45 436628 39407 63012942
Blood potassium decreased 144.52 14.64 54 436619 41972 63010377
Hospitalisation 143.37 14.64 227 436446 84854 62967495
Respiratory distress 142.00 14.64 30 436643 33921 63018428
Chronic obstructive pulmonary disease 141.83 14.64 133 436540 62553 62989796
Suicidal ideation 141.75 14.64 132 436541 62289 62990060
Hypomagnesaemia 141.47 14.64 16 436657 28721 63023628
Multiple organ dysfunction syndrome 141.11 14.64 110 436563 56642 62995707
Dyskinesia 140.77 14.64 25 436648 31977 63020372
Paraesthesia 140.15 14.64 579 436094 156387 62895962
Cerebral haemorrhage 139.62 14.64 22 436651 30707 63021642
Rheumatoid lung 138.44 14.64 151 436522 3697 63048652
Erythema 137.93 14.64 680 435993 175071 62877278
Chronic kidney disease 137.64 14.64 70 436603 45328 63007021
Skin necrosis 136.85 14.64 299 436374 13651 63038698
Fatigue 136.01 14.64 7431 429242 880597 62171752
Oxygen saturation decreased 135.84 14.64 251 436422 88334 62964015
Pyrexia 135.71 14.64 2348 434325 468130 62584219
Limb deformity 135.28 14.64 152 436521 3850 63048499
Haemorrhage 135.11 14.64 132 436541 60890 62991459
Thrombosis 133.33 14.64 149 436524 64606 62987743
Melaena 132.96 14.64 24 436649 30341 63022008
Altered state of consciousness 132.22 14.64 11 436662 25219 63027130
Dyspnoea exertional 131.72 14.64 132 436541 60170 62992179
Haematochezia 131.59 14.64 105 436568 53439 62998910
Haematoma 131.58 14.64 38 436635 34782 63017567
Urinary incontinence 130.43 14.64 30 436643 31984 63020365
Heart rate increased 129.97 14.64 284 436389 93954 62958395
Blood calcium decreased 129.53 14.64 15 436658 26436 63025913
Generalised tonic-clonic seizure 129.09 14.64 22 436651 28994 63023355
Aphasia 128.47 14.64 34 436639 32966 63019383
Blood creatinine increased 127.64 14.64 257 436416 87587 62964762
Lymphocyte count decreased 126.00 14.64 27 436646 30230 63022119
Metastases to liver 124.73 14.64 10 436663 23629 63028720
Inappropriate schedule of product administration 124.71 14.64 337 436336 103628 62948721
Product quality issue 123.47 14.64 46 436627 35819 63016530
Full blood count abnormal 122.86 14.64 33 436640 31684 63020665
Musculoskeletal deformity 122.30 14.64 103 436570 1806 63050543
Pulmonary toxicity 121.83 14.64 227 436446 9228 63043121
Depressed mood 121.80 14.64 62 436611 40129 63012220
Adverse reaction 121.65 14.64 237 436436 9966 63042383
Oropharyngeal pain 121.24 14.64 296 436377 94191 62958158
Drug reaction with eosinophilia and systemic symptoms 120.58 14.64 41 436632 33795 63018554
Dysuria 120.02 14.64 41 436632 33697 63018652
Night sweats 119.93 14.64 657 436016 48157 63004192
Abnormal behaviour 119.06 14.64 7 436666 21419 63030930
Drug level increased 118.90 14.64 10 436663 22726 63029623
Sciatica 118.22 14.64 509 436164 33815 63018534
Intentional product use issue 117.35 14.64 1371 435302 126521 62925828
Presyncope 117.34 14.64 24 436649 27761 63024588
Incorrect dose administered 114.91 14.64 146 436527 59822 62992527
Cardiac disorder 114.74 14.64 108 436565 50708 63001641
Irritability 113.65 14.64 38 436635 31656 63020693
Ejection fraction decreased 113.62 14.64 11 436662 22321 63030028
Vertigo 113.52 14.64 147 436526 59740 62992609
Aggression 113.40 14.64 14 436659 23484 63028865
Nodule 113.00 14.64 360 436313 20666 63031683
Colitis 112.11 14.64 101 436572 48427 63003922
Abdominal distension 111.39 14.64 271 436402 86344 62966005
Device dislocation 111.09 14.64 21 436652 25684 63026665
Acute respiratory failure 110.95 14.64 49 436624 34436 63017913
Sleep disorder 108.95 14.64 945 435728 80621 62971728
Therapy interrupted 107.81 14.64 44 436629 32411 63019938
Flatulence 107.48 14.64 52 436621 34650 63017699
Muscle spasticity 107.12 14.64 362 436311 21432 63030917
Psychotic disorder 106.96 14.64 23 436650 25689 63026660
Joint destruction 106.70 14.64 170 436503 6082 63046267
Metastases to bone 105.25 14.64 11 436662 21008 63031341
Accidental overdose 105.19 14.64 17 436656 23292 63029057
Foetal exposure during pregnancy 105.09 14.64 44 436629 31918 63020431
Ear pain 104.62 14.64 509 436164 35609 63016740
Right ventricular failure 104.21 14.64 3 436670 17185 63035164
Pulmonary hypertension 104.21 14.64 63 436610 37060 63015289
Ventricular tachycardia 103.90 14.64 9 436664 19970 63032379
Foot operation 103.87 14.64 182 436491 7049 63045300
Rash erythematous 103.66 14.64 84 436589 42426 63009923
Hallucination, visual 102.28 14.64 8 436665 19290 63033059
Pancreatitis acute 102.00 14.64 30 436643 27136 63025213
Joint effusion 101.83 14.64 303 436370 16757 63035592
Withdrawal syndrome 101.34 14.64 10 436663 19987 63032362
Arrhythmia 101.22 14.64 69 436604 38071 63014278
Mucosal inflammation 101.04 14.64 104 436569 46824 63005525
Sleep apnoea syndrome 100.90 14.64 37 436636 29096 63023253
Blood urea increased 99.29 14.64 29 436644 26350 63025999
Neutropenic sepsis 99.19 14.64 3 436670 16435 63035914
Pallor 99.03 14.64 43 436630 30525 63021824
Toxic epidermal necrolysis 98.81 14.64 26 436647 25308 63027041
Impaired work ability 98.32 14.64 304 436369 17171 63035178
Musculoskeletal pain 97.83 14.64 1018 435655 91259 62961090
Clostridium difficile colitis 97.46 14.64 13 436660 20556 63031793
Abdominal pain lower 97.07 14.64 28 436645 25650 63026699
Red blood cell sedimentation rate 96.97 14.64 142 436531 4712 63047637
Therapy cessation 96.85 14.64 44 436629 30413 63021936
Circulatory collapse 96.79 14.64 17 436656 21921 63030428
Drug ineffective for unapproved indication 96.75 14.64 57 436616 34006 63018343
Burning sensation 96.63 14.64 140 436533 54267 62998082
Sinus tachycardia 96.39 14.64 24 436649 24244 63028105
Dementia 96.30 14.64 9 436664 18785 63033564
Shoulder arthroplasty 96.26 14.64 128 436545 3874 63048475
Neurotoxicity 96.11 14.64 5 436668 16985 63035364
Weight decreased 96.07 14.64 1333 435340 275465 62776884
Tinnitus 95.16 14.64 64 436609 35564 63016785
Blood creatine phosphokinase increased 95.16 14.64 45 436628 30385 63021964
Vaginal haemorrhage 95.05 14.64 35 436638 27452 63024897
Pericardial effusion 94.69 14.64 44 436629 30014 63022335
Myocardial infarction 94.51 14.64 360 436313 99533 62952816
Cholelithiasis 93.83 14.64 98 436575 43827 63008522
Angioedema 93.76 14.64 115 436558 47850 63004499
Abortion spontaneous 93.48 14.64 112 436561 47083 63005266
Tuberculin test positive 93.36 14.64 118 436555 3393 63048956
Oral mucosal exfoliation 93.33 14.64 83 436590 1571 63050778
Gastrointestinal pain 93.03 14.64 207 436466 9569 63042780
Enthesopathy 93.02 14.64 192 436481 8422 63043927
Transient ischaemic attack 92.81 14.64 74 436599 37679 63014670
Inappropriate antidiuretic hormone secretion 92.66 14.64 3 436670 15459 63036890
Blood bilirubin increased 92.31 14.64 72 436601 37068 63015281
Bone marrow failure 92.08 14.64 43 436630 29247 63023102
Upper gastrointestinal haemorrhage 91.54 14.64 11 436662 18841 63033508
Product administration error 91.22 14.64 21 436652 22376 63029973
Pollakiuria 90.98 14.64 39 436634 27898 63024451
Body temperature increased 90.97 14.64 500 436173 36692 63015657
Blood sodium decreased 90.66 14.64 27 436646 24225 63028124
Haemoptysis 90.57 14.64 42 436631 28684 63023665
X-ray abnormal 90.22 14.64 183 436490 7927 63044422
Lip swelling 89.62 14.64 51 436622 31012 63021337
Septic shock 89.24 14.64 204 436469 66425 62985924
Ankylosing spondylitis 88.89 14.64 212 436461 10262 63042087
Physical disability 88.86 14.64 102 436571 2646 63049703
Acute myocardial infarction 88.11 14.64 56 436617 32068 63020281
Diabetic ketoacidosis 88.08 14.64 17 436656 20488 63031861
Muscle twitching 87.30 14.64 15 436658 19653 63032696
Cholestasis 86.84 14.64 47 436626 29387 63022962
Haematuria 86.84 14.64 46 436627 29111 63023238
Skin exfoliation 86.74 14.64 101 436572 43001 63009348
Product prescribing error 86.74 14.64 36 436637 26253 63026096
Memory impairment 86.66 14.64 395 436278 103863 62948486
Swelling face 85.29 14.64 194 436479 63281 62989068
Ulcer 85.23 14.64 381 436292 25726 63026623
Feeling hot 85.14 14.64 134 436539 50220 63002129
Hepatic function abnormal 84.96 14.64 78 436595 37064 63015285
Face oedema 84.24 14.64 18 436655 20194 63032155
Retinal toxicity 84.18 14.64 70 436603 1205 63051144
Joint laxity 83.99 14.64 94 436579 2370 63049979
Arthrodesis 83.96 14.64 100 436573 2701 63049648
Renal impairment 83.85 14.64 318 436355 88037 62964312
Cellulitis 83.73 14.64 286 436387 81672 62970677
Head injury 83.41 14.64 42 436631 27354 63024995
Hypocalcaemia 83.32 14.64 58 436615 31655 63020694
Sinus bradycardia 83.21 14.64 4 436669 14547 63037802
Creatinine renal clearance decreased 83.05 14.64 8 436665 16300 63036049
Myoclonus 82.92 14.64 7 436666 15861 63036488
Hepatotoxicity 82.72 14.64 486 436187 36555 63015794
Leukocytosis 81.64 14.64 38 436635 25897 63026452
Infusion site pain 81.53 14.64 10 436663 16859 63035490
Panic attack 81.43 14.64 26 436647 22305 63030044
Drug eruption 81.41 14.64 402 436271 28292 63024057
Product substitution issue 81.06 14.64 8 436665 15988 63036361
Macular degeneration 81.04 14.64 33 436640 24343 63028006
Device issue 81.02 14.64 31 436642 23750 63028599
Acute myeloid leukaemia 80.85 14.64 11 436662 17136 63035213
Lacrimation increased 80.79 14.64 21 436652 20610 63031739
Paraesthesia oral 80.56 14.64 17 436656 19239 63033110
Rheumatoid factor negative 80.51 14.64 51 436622 560 63051789
Hemiparesis 79.91 14.64 30 436643 23252 63029097
Blood pressure increased 79.28 14.64 722 435951 161340 62891009
Status epilepticus 78.84 14.64 7 436666 15226 63037123
Pruritus allergic 78.75 14.64 74 436599 1508 63050841
Mental disorder 78.51 14.64 40 436633 25879 63026470
Cerebral infarction 78.38 14.64 33 436640 23860 63028489
Dysphonia 78.35 14.64 129 436544 47485 63004864
Electrolyte imbalance 77.55 14.64 21 436652 20055 63032294
Disseminated intravascular coagulation 77.32 14.64 18 436655 19033 63033316
Emotional distress 77.29 14.64 66 436607 32483 63019866
Epilepsy 77.28 14.64 45 436628 27020 63025329
Respiratory disorder 76.71 14.64 496 436177 38586 63013763
Spinal column injury 76.44 14.64 82 436591 1969 63050380
Stevens-Johnson syndrome 76.34 14.64 38 436635 24912 63027437
Transfusion 76.10 14.64 8 436665 15209 63037140
General physical health deterioration 75.73 14.64 1867 434806 199535 62852814
Eye pain 75.20 14.64 73 436600 33781 63018568
Small intestinal obstruction 75.07 14.64 17 436656 18320 63034029
Coordination abnormal 75.03 14.64 5 436668 13768 63038581
Accidental exposure to product 74.86 14.64 48 436625 27357 63024992
Poisoning 74.56 14.64 5 436668 13695 63038654
Surgical failure 74.32 14.64 58 436615 908 63051441
Obstructive airways disorder 73.89 14.64 25 436648 20674 63031675
Bacteraemia 73.23 14.64 15 436658 17333 63035016
Agranulocytosis 72.89 14.64 41 436632 25093 63027256
Labelled drug-drug interaction medication error 72.60 14.64 5 436668 13394 63038955
Dystonia 72.48 14.64 6 436667 13813 63038536
Intestinal obstruction 71.74 14.64 64 436609 30835 63021514
Pain in jaw 71.42 14.64 118 436555 43378 63008971
Dislocation of vertebra 71.37 14.64 173 436500 8462 63043887
Loss of consciousness 71.30 14.64 497 436176 117624 62934725
Renal disorder 69.94 14.64 74 436599 32900 63019449
Diplopia 69.84 14.64 38 436635 23690 63028659
Pulmonary arterial hypertension 69.66 14.64 34 436639 22543 63029806
Seronegative arthritis 69.43 14.64 109 436564 3850 63048499
Joint injury 69.29 14.64 393 436280 29179 63023170
Hot flush 69.02 14.64 156 436517 51003 63001346
Mania 68.84 14.64 4 436669 12363 63039986
Wrist deformity 68.77 14.64 79 436594 2051 63050298
Device difficult to use 68.68 14.64 5 436668 12791 63039558
Swollen tongue 68.48 14.64 83 436590 34717 63017632
Hypothermia 68.28 14.64 7 436666 13574 63038775
Speech disorder 67.86 14.64 109 436564 40520 63011829
Tuberculosis 67.75 14.64 200 436473 11011 63041338
Eosinophilia 67.62 14.64 36 436637 22720 63029629
Skin discolouration 67.50 14.64 97 436576 37731 63014618
Paranoia 67.47 14.64 3 436670 11676 63040673
Red cell distribution width decreased 67.37 14.64 77 436596 1988 63050361
Haemorrhage intracranial 67.25 14.64 7 436666 13412 63038937
Incontinence 67.16 14.64 3 436670 11629 63040720
Exostosis 67.07 14.64 272 436401 17590 63034759
Blood glucose decreased 67.04 14.64 30 436643 20922 63031427
Bone swelling 67.03 14.64 70 436603 1628 63050721
Complication associated with device 67.03 14.64 17 436656 16961 63035388
Tachypnoea 67.02 14.64 18 436655 17284 63035065
Cardiogenic shock 66.96 14.64 20 436653 17912 63034437
Systemic lupus erythematosus rash 66.85 14.64 80 436593 2172 63050177
Adjustment disorder with depressed mood 66.46 14.64 187 436486 10017 63042332
Breast cancer stage III 66.34 14.64 189 436484 10197 63042152
Frequent bowel movements 66.13 14.64 38 436635 22984 63029365
Pancreatitis 65.84 14.64 150 436523 48905 63003444
Vascular access complication 65.78 14.64 77 436596 2041 63050308
Loose body in joint 65.64 14.64 61 436612 1225 63051124
Basal cell carcinoma 65.59 14.64 372 436301 27619 63024730
Metastases to central nervous system 65.26 14.64 7 436666 13098 63039251
Anuria 64.33 14.64 6 436667 12545 63039804
Visual acuity reduced 64.17 14.64 35 436638 21791 63030558
Joint dislocation 64.13 14.64 278 436395 18522 63033827
Premature labour 64.03 14.64 6 436667 12498 63039851
Diabetes mellitus inadequate control 64.01 14.64 13 436660 15113 63037236
Eye swelling 63.83 14.64 43 436630 23875 63028474
Ischaemic stroke 63.56 14.64 22 436651 17935 63034414
Subdural haematoma 63.44 14.64 11 436662 14317 63038032
Metastases to lung 63.01 14.64 7 436666 12743 63039606
Malnutrition 62.99 14.64 14 436659 15284 63037065
Nervousness 62.98 14.64 72 436601 30907 63021442
Product use in unapproved indication 62.93 14.64 860 435813 178220 62874129
Clostridium difficile infection 62.52 14.64 68 436605 29854 63022495
Influenza 61.96 14.64 465 436208 108257 62944092
Respiratory depression 61.90 14.64 10 436663 13705 63038644
Fear 61.83 14.64 16 436657 15750 63036599
Mitral valve incompetence 61.23 14.64 29 436644 19565 63032784
Nasal congestion 61.21 14.64 238 436435 65422 62986927
Blood magnesium decreased 60.98 14.64 9 436664 13189 63039160
Peritonitis 60.75 14.64 21 436652 17133 63035216
Muscular weakness 60.74 14.64 543 436130 121810 62930539
Left ventricular dysfunction 60.74 14.64 6 436667 11982 63040367
Nightmare 60.61 14.64 28 436645 19166 63033183
Incorrect product administration duration 60.59 14.64 5 436668 11541 63040808
Mydriasis 60.53 14.64 6 436667 11950 63040399
Viral infection 60.20 14.64 95 436578 35568 63016781
Hepatic failure 60.17 14.64 95 436578 35561 63016788
Ankle arthroplasty 59.82 14.64 68 436605 1745 63050604
Therapeutic response unexpected 59.80 14.64 27 436646 18732 63033617
Cyanosis 59.51 14.64 21 436652 16914 63035435
Haematemesis 59.35 14.64 73 436600 30339 63022010
Extrapyramidal disorder 59.25 14.64 10 436663 13274 63039075
Mean platelet volume decreased 59.09 14.64 82 436591 2587 63049762
Infusion site erythema 58.77 14.64 6 436667 11673 63040676
Cholecystitis chronic 58.76 14.64 3 436670 10358 63041991
Gastritis 58.68 14.64 104 436569 37199 63015150
No adverse event 58.55 14.64 123 436550 41282 63011067
Premature baby 58.46 14.64 35 436638 20700 63031649
Caesarean section 58.36 14.64 22 436651 17010 63035339
Myopathy 58.31 14.64 5 436668 11186 63041163
International normalised ratio fluctuation 57.68 14.64 78 436595 2400 63049949
Emotional disorder 57.66 14.64 11 436662 13368 63038981
Ileus 57.64 14.64 15 436658 14710 63037639
Muscle rigidity 57.63 14.64 6 436667 11494 63040855
Demyelination 57.58 14.64 139 436534 6781 63045568
Productive cough 57.09 14.64 232 436441 62976 62989373
Retinitis 56.50 14.64 129 436544 6067 63046282
Shock 56.41 14.64 47 436626 23416 63028933
Aspiration 56.12 14.64 5 436668 10846 63041503
Hypercholesterolaemia 55.69 14.64 292 436381 21042 63031307
Mean cell volume decreased 55.68 14.64 99 436574 3879 63048470
Cytomegalovirus infection 55.47 14.64 38 436635 20914 63031435
Hypophosphataemia 54.67 14.64 7 436666 11419 63040930
Hypersomnia 54.49 14.64 28 436645 18027 63034322
Anti-cyclic citrullinated peptide antibody 54.37 14.64 134 436539 6624 63045725
Investigation abnormal 53.97 14.64 67 436606 1891 63050458
Hyperbilirubinaemia 53.96 14.64 7 436666 11307 63041042
Device related infection 53.65 14.64 49 436624 23343 63029006
Procedural pain 53.36 14.64 42 436631 21527 63030822
Tricuspid valve incompetence 53.35 14.64 17 436656 14604 63037745
Supraventricular tachycardia 53.14 14.64 16 436657 14255 63038094
Ataxia 53.13 14.64 19 436654 15176 63037173
Blindness 52.75 14.64 43 436630 21656 63030693
Multiple fractures 52.32 14.64 154 436519 8464 63043885
Blood calcium increased 52.12 14.64 3 436670 9347 63043002
Infusion site swelling 51.92 14.64 4 436669 9766 63042583
Myelosuppression 51.62 14.64 52 436621 23651 63028698
Dermatitis atopic 51.62 14.64 4 436669 9720 63042629
Gait disturbance 51.43 14.64 1636 435037 181542 62870807
Hepatic encephalopathy 51.43 14.64 8 436665 11274 63041075
Product label confusion 51.27 14.64 63 436610 1759 63050590
Acidosis 51.12 14.64 8 436665 11225 63041124
Anal incontinence 50.95 14.64 15 436658 13561 63038788
Gastric disorder 50.95 14.64 435 436238 36934 63015415
Back injury 50.64 14.64 164 436509 9496 63042853
Ventricular fibrillation 50.63 14.64 10 436663 11857 63040492
Ocular hyperaemia 50.51 14.64 59 436614 25085 63027264
Multiple sclerosis 50.25 14.64 56 436617 24316 63028033
Colitis ischaemic 50.18 14.64 7 436666 10701 63041648
Retching 50.04 14.64 19 436654 14626 63037723
Stress cardiomyopathy 49.85 14.64 4 436669 9446 63042903
Tumour lysis syndrome 49.76 14.64 3 436670 8987 63043362
Hip fracture 49.29 14.64 79 436594 29395 63022954
Bloody discharge 49.19 14.64 57 436616 1494 63050855
Mental impairment 48.96 14.64 18 436655 14133 63038216
Tubulointerstitial nephritis 48.93 14.64 39 436634 19864 63032485
Toxic skin eruption 48.79 14.64 14 436659 12871 63039478
Infusion site reaction 48.59 14.64 88 436585 3499 63048850
Onychomycosis 48.40 14.64 142 436531 7790 63044559
Synovial cyst 48.40 14.64 170 436503 10263 63042086
Jaundice 48.36 14.64 79 436594 29172 63023177
Electrocardiogram abnormal 48.10 14.64 4 436669 9175 63043174
Aplastic anaemia 47.93 14.64 5 436668 9564 63042785
Rash macular 47.82 14.64 54 436619 23310 63029039
Haemorrhoids 47.78 14.64 49 436624 22101 63030248
Urine output decreased 47.64 14.64 10 436663 11360 63040989
Bronchitis 47.54 14.64 590 436083 124345 62928004
Acute respiratory distress syndrome 47.51 14.64 55 436618 23479 63028870
Sensitivity to weather change 47.50 14.64 133 436540 7104 63045245
Cystitis 47.09 14.64 206 436467 54785 62997564
Hypothyroidism 46.85 14.64 144 436529 42488 63009861
Coronary artery disease 46.78 14.64 95 436578 32282 63020067
Abnormal dreams 46.72 14.64 8 436665 10508 63041841
Contusion 46.64 14.64 1357 435316 148687 62903662
Cardiomegaly 46.56 14.64 32 436641 17582 63034767
Upper respiratory tract infection 46.23 14.64 352 436321 81695 62970654
Lymphopenia 46.21 14.64 35 436638 18292 63034057
Delusion 45.61 14.64 13 436660 12004 63040345
Ventricular extrasystoles 45.57 14.64 12 436661 11675 63040674
Injection site mass 45.31 14.64 37 436636 18619 63033730
Central nervous system lesion 45.29 14.64 9 436664 10626 63041723
Impaired quality of life 45.27 14.64 19 436654 13764 63038585
Throat tightness 45.21 14.64 63 436610 24824 63027525
Atrioventricular block complete 44.93 14.64 3 436670 8248 63044101
Hepatic cytolysis 44.87 14.64 25 436648 15382 63036967
Head discomfort 44.86 14.64 18 436655 13397 63038952
Renal tubular necrosis 44.81 14.64 13 436660 11865 63040484
Sinus disorder 44.76 14.64 62 436611 24491 63027858
Malaise 44.66 14.64 2372 434301 413582 62638767
Angina pectoris 44.53 14.64 87 436586 29991 63022358
Troponin increased 44.31 14.64 8 436665 10113 63042236
Mycotic allergy 44.17 14.64 44 436629 966 63051383
Acute generalised exanthematous pustulosis 44.03 14.64 11 436662 11088 63041261
Breast cancer metastatic 43.81 14.64 14 436659 12004 63040345
Tardive dyskinesia 43.75 14.64 4 436669 8498 63043851
Wrist surgery 43.69 14.64 41 436632 834 63051515
Thirst 43.54 14.64 21 436652 14020 63038329
Restless legs syndrome 43.48 14.64 38 436635 18493 63033856
Seasonal allergy 43.34 14.64 48 436625 20902 63031447
Muscle tightness 43.13 14.64 14 436659 11886 63040463
Bone density abnormal 43.05 14.64 81 436592 3317 63049032
Apathy 43.02 14.64 5 436668 8789 63043560
Throat irritation 42.92 14.64 125 436548 37522 63014827
Sensory loss 42.91 14.64 9 436664 10229 63042120
Pre-eclampsia 42.73 14.64 6 436667 9127 63043222
Hyperlipidaemia 42.55 14.64 43 436630 19528 63032821
Hepatocellular injury 42.47 14.64 77 436596 27304 63025045
Therapy non-responder 42.41 14.64 746 435927 75155 62977194
Renal injury 42.33 14.64 7 436666 9432 63042917
Faeces discoloured 42.18 14.64 39 436634 18470 63033879
Food allergy 42.06 14.64 13 436660 11388 63040961
Back pain 42.02 14.64 1441 435232 262704 62789645
Illness 41.87 14.64 184 436489 48875 63003474
Hypotonia 41.39 14.64 7 436666 9278 63043071
Brain oedema 41.39 14.64 23 436650 14172 63038177
Oesophagitis 41.38 14.64 26 436647 14982 63037367
Influenza like illness 41.38 14.64 279 436394 66545 62985804
Headache 41.34 14.64 3772 432901 629469 62422880
Fine motor skill dysfunction 41.31 14.64 98 436575 4727 63047622
Eosinophil count increased 41.15 14.64 12 436661 10916 63041433
Device breakage 41.10 14.64 14 436659 11528 63040821
Pharyngitis 40.98 14.64 258 436415 19885 63032464
Amenorrhoea 40.97 14.64 9 436664 9905 63042444
Feeling cold 40.92 14.64 63 436610 23825 63028524
Injection site erythema 40.88 14.64 370 436303 82804 62969545
Shock haemorrhagic 40.85 14.64 9 436664 9886 63042463
Respiratory tract infection 40.85 14.64 147 436526 41336 63011013
Haemodynamic instability 40.81 14.64 7 436666 9183 63043166
Transaminases abnormal 40.75 14.64 35 436638 631 63051718
Rhinitis allergic 40.43 14.64 15 436658 11712 63040637
Oliguria 40.26 14.64 7 436666 9094 63043255
Urticarial vasculitis 40.17 14.64 35 436638 644 63051705
Prescribed overdose 40.15 14.64 385 436288 33768 63018581
Bronchitis chronic 40.11 14.64 91 436582 4262 63048087
Lower gastrointestinal haemorrhage 39.84 14.64 4 436669 7886 63044463
Dermatitis contact 39.81 14.64 13 436660 10995 63041354
Myelodysplastic syndrome 39.74 14.64 34 436639 16720 63035629
Anticipatory anxiety 39.72 14.64 46 436627 1205 63051144
Wheezing 39.62 14.64 443 436230 95152 62957197
Chromaturia 39.56 14.64 34 436639 16683 63035666
Ovarian cyst 39.51 14.64 31 436642 15914 63036435
Coagulopathy 39.37 14.64 50 436623 20494 63031855
Dactylitis 39.16 14.64 67 436606 2545 63049804
Osteonecrosis of jaw 39.05 14.64 118 436555 35005 63017344
Lupus-like syndrome 39.00 14.64 208 436465 15087 63037262
Glomerular filtration rate decreased 38.87 14.64 22 436651 13419 63038930
Fear of injection 38.80 14.64 123 436550 7041 63045308
Atrioventricular block first degree 38.58 14.64 3 436670 7270 63045079
Hepatitis 38.46 14.64 431 436242 39357 63012992
Atelectasis 38.42 14.64 55 436618 21428 63030921
Pneumonia viral 38.41 14.64 131 436542 7791 63044558
Neuralgia 38.37 14.64 75 436598 25851 63026498
Hyperthyroidism 38.33 14.64 27 436646 14646 63037703
Atrioventricular block 38.29 14.64 4 436669 7643 63044706
Gestational diabetes 38.16 14.64 6 436667 8390 63043959
Joint arthroplasty 38.09 14.64 68 436605 2673 63049676
Neck deformity 38.03 14.64 59 436614 2062 63050287
Cholecystitis 37.97 14.64 30 436643 15347 63037002
Posterior reversible encephalopathy syndrome 37.83 14.64 38 436635 17307 63035042
Normal newborn 37.83 14.64 6 436667 8335 63044014
Eructation 37.78 14.64 6 436667 8327 63044022
Polyarthritis 37.69 14.64 154 436519 9992 63042357
Blood loss anaemia 37.54 14.64 8 436665 8993 63043356
White blood cell count increased 37.41 14.64 189 436484 48372 63003977
Hypoacusis 37.39 14.64 68 436605 24083 63028266
Mood altered 37.38 14.64 28 436645 14715 63037634
Haemodialysis 37.22 14.64 8 436665 8939 63043410
Extremity contracture 37.08 14.64 45 436628 1240 63051109
Device malfunction 36.84 14.64 41 436632 17816 63034533
Eyelid oedema 36.81 14.64 13 436660 10466 63041883
Ovarian neoplasm 36.69 14.64 38 436635 875 63051474
Prescribed underdose 36.56 14.64 338 436335 29351 63022998
Infusion site extravasation 36.51 14.64 13 436660 10413 63041936
Deep vein thrombosis postoperative 36.42 14.64 165 436508 11204 63041145
Subarachnoid haemorrhage 36.37 14.64 27 436646 14256 63038093
Pemphigoid 36.37 14.64 4 436669 7340 63045009
Femur fracture 36.22 14.64 443 436230 41313 63011036
Breast cancer stage I 36.11 14.64 3 436670 6886 63045463
Epstein-Barr virus infection 36.04 14.64 6 436667 8044 63044305
Underdose 36.00 14.64 85 436588 27371 63024978
Chronic sinusitis 35.76 14.64 22 436651 12821 63039528
Hair follicle tumour benign 35.61 14.64 27 436646 404 63051945
Ear infection 35.61 14.64 411 436262 37802 63014547
Mouth ulceration 35.46 14.64 365 436308 32619 63019730
Heavy menstrual bleeding 35.38 14.64 42 436631 17731 63034618
Bedridden 35.11 14.64 160 436513 10891 63041458
Skin laceration 35.10 14.64 64 436609 22644 63029705
Peripheral coldness 35.05 14.64 20 436653 12145 63040204
Injection site swelling 35.04 14.64 188 436485 47384 63004965
Soft tissue disorder 34.86 14.64 87 436586 4335 63048014
End stage renal disease 34.84 14.64 3 436670 6690 63045659
Colitis ulcerative 34.83 14.64 80 436593 26011 63026338
Thyroid neoplasm 34.81 14.64 82 436591 3937 63048412
Mean cell haemoglobin decreased 34.80 14.64 96 436577 5083 63047266
Musculoskeletal chest pain 34.79 14.64 57 436616 21026 63031323
Rhinorrhoea 34.78 14.64 286 436387 65291 62987058
Cutaneous vasculitis 34.75 14.64 97 436576 5172 63047177
Blood lactic acid increased 34.74 14.64 4 436669 7082 63045267
Rib fracture 34.65 14.64 64 436609 22533 63029816
Nocturia 34.44 14.64 7 436666 8134 63044215
Myocarditis 34.29 14.64 14 436659 10311 63042038
Allergic oedema 34.25 14.64 35 436638 793 63051556
Eye pruritus 34.18 14.64 47 436626 18624 63033725
Toxic encephalopathy 34.11 14.64 3 436670 6576 63045773
Suspected suicide 34.04 14.64 3 436670 6565 63045784
Upper-airway cough syndrome 34.02 14.64 18 436655 11400 63040949
Lymphoedema 34.01 14.64 19 436654 11673 63040676
Joint space narrowing 33.99 14.64 30 436643 562 63051787
Immune thrombocytopenia 33.95 14.64 15 436658 10541 63041808
Atrial septal defect 33.81 14.64 4 436669 6934 63045415
Vascular device infection 33.75 14.64 5 436668 7307 63045042
Lung neoplasm malignant 33.42 14.64 52 436621 19581 63032768
Pustular psoriasis 33.35 14.64 88 436585 4538 63047811
Delirium 33.34 14.64 207 436466 50334 63002015
Acute coronary syndrome 33.19 14.64 14 436659 10112 63042237
Walking aid user 33.19 14.64 154 436519 10563 63041786
Haemolytic anaemia 33.18 14.64 14 436659 10111 63042238
Hypoalbuminaemia 33.18 14.64 20 436653 11785 63040564
Drug level decreased 33.11 14.64 7 436666 7912 63044437
Hereditary angioedema 33.06 14.64 6 436667 7556 63044793
Failure to thrive 33.05 14.64 5 436668 7193 63045156
Generalised oedema 32.99 14.64 36 436637 15782 63036567
Thinking abnormal 32.88 14.64 16 436657 10627 63041722
Atrial flutter 32.86 14.64 13 436660 9759 63042590
Mycobacterium tuberculosis complex test positive 32.78 14.64 57 436616 2194 63050155
Hypoaesthesia oral 32.72 14.64 25 436648 13008 63039341
Hypermobility syndrome 32.62 14.64 34 436639 789 63051560
Blood triglycerides increased 32.59 14.64 23 436650 12465 63039884
Acute pulmonary oedema 32.53 14.64 8 436665 8150 63044199
Infiltration anaesthesia 32.53 14.64 19 436654 178 63052171
Purpura 32.40 14.64 19 436654 11366 63040983
Impaired gastric emptying 32.39 14.64 149 436524 10183 63042166
Hiatus hernia 32.37 14.64 62 436611 21532 63030817
Wound infection 32.29 14.64 255 436418 21155 63031194
Unevaluable event 32.09 14.64 214 436459 51172 63001177
Increased appetite 32.07 14.64 13 436660 9617 63042732
Hemiplegia 32.02 14.64 12 436661 9311 63043038
Neutrophil count increased 31.90 14.64 40 436633 16487 63035862
Migraine 31.87 14.64 509 436164 102837 62949512
Menstruation irregular 31.85 14.64 5 436668 6999 63045350
Nystagmus 31.81 14.64 3 436670 6217 63046132
Lymphadenopathy 31.76 14.64 146 436527 38312 63014037
Dialysis 31.72 14.64 16 436657 10411 63041938
Bradyphrenia 31.70 14.64 5 436668 6975 63045374
Personality change 31.66 14.64 5 436668 6968 63045381
Unintended pregnancy 31.55 14.64 3 436670 6176 63046173
Rash papular 31.37 14.64 37 436636 15665 63036684
Escherichia infection 31.34 14.64 25 436648 12729 63039620
Skin papilloma 31.33 14.64 90 436583 4879 63047470
Nephropathy toxic 31.24 14.64 13 436660 9466 63042883
Drug tolerance 31.18 14.64 112 436561 6837 63045512
Progressive multifocal leukoencephalopathy 31.16 14.64 26 436647 12945 63039404
Labile blood pressure 31.02 14.64 49 436624 1740 63050609
Lower limb fracture 30.96 14.64 278 436395 23943 63028406
Female genital tract fistula 30.96 14.64 7 436666 7552 63044797
Sensory disturbance 30.93 14.64 29 436644 13643 63038706
Foetal growth restriction 30.92 14.64 7 436666 7546 63044803
Taste disorder 30.88 14.64 29 436644 13633 63038716
Alanine aminotransferase abnormal 30.77 14.64 84 436589 4420 63047929
Pulmonary haemorrhage 30.75 14.64 6 436667 7175 63045174
Skin reaction 30.71 14.64 191 436482 14658 63037691
Nasal polyps 30.65 14.64 3 436670 6036 63046313
Heart rate irregular 30.54 14.64 68 436605 22353 63029996
Spinal compression fracture 30.35 14.64 32 436641 14251 63038098
Pulmonary mass 30.26 14.64 262 436411 22334 63030015
Weight increased 30.20 14.64 2132 434541 258660 62793689
Cerebral ischaemia 30.15 14.64 5 436668 6723 63045626
Prothrombin time prolonged 30.12 14.64 14 436659 9550 63042799
Ageusia 30.03 14.64 30 436643 13698 63038651
Needle issue 29.98 14.64 17 436656 10359 63041990
Vasculitic rash 29.