leflunomide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1552 75706-12-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • leflunomide medac
  • leflunomide
  • arava
  • avara
  • leflunomida
  • leflunomidum
  • lefumide
  • repso
An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
  • Molecular weight: 270.21
  • Formula: C12H9F3N2O2
  • CLOGP: 2.36
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 55.13
  • ALOGS: -3.51
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.02 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.23 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 80 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
fu (Fraction unbound in plasma) 0.00 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 3.188 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.687 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 74.645 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 13.428 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 5.560 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 9.320 % High 1
herg hERG pIC50 4.637 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 5.794 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 9.016 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 5.820 % High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.897 High 1
mh-clint Mouse hepatocyte intrinsic clearance 40.832 High 1
mppb Mouse plasma protein binding (% unbound) 5.300 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.514 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 1
pppb Pig plasma protein binding (% unbound) 5.250 % High 1
rh-clint Rat hepatocyte intrinsic clearance 10.641 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 53.100 % High 1
rppb Rat plasma protein binding (% unbound) 5.500 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 120.781 uM High 1

Approvals:

DateAgencyCompanyOrphan
Sept. 10, 1998 FDA SANOFI AVENTIS US
Sept. 2, 1999 EMA Sanofi-aventis Deutschland GmbH

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 4404.18 13.47 21152 656456 1363146 88587693
Drug intolerance 4236.93 13.47 9919 667689 437672 89513167
Contraindicated product administered 3855.82 13.47 7822 669786 312317 89638522
Joint swelling 3379.92 13.47 9810 667798 493490 89457349
Synovitis 3005.88 13.47 7207 670401 322545 89628294
Arthropathy 2685.10 13.47 7374 670234 358868 89591971
Treatment failure 2546.45 13.47 6433 671175 297495 89653344
Pemphigus 2459.82 13.47 6646 670962 320218 89630621
Therapeutic product effect decreased 2409.78 13.47 5956 671652 271615 89679224
Systemic lupus erythematosus 2364.45 13.47 6991 670617 354905 89595934
Rheumatoid arthritis 2116.60 13.47 6735 670873 355879 89594960
Glossodynia 2108.61 13.47 6224 671384 315555 89635284
Swelling 2088.32 13.47 7379 670229 411679 89539160
Hand deformity 2061.73 13.47 5857 671751 290505 89660334
Abdominal discomfort 2044.26 13.47 8004 669604 469324 89481515
Alopecia 1924.54 13.47 8056 669552 487015 89463824
Death 1624.24 13.47 691 676917 455860 89494979
Acute kidney injury 1487.99 13.47 294 677314 320093 89630746
Anti-cyclic citrullinated peptide antibody positive 1446.16 13.47 4466 673142 231967 89718872
Hepatic enzyme increased 1393.24 13.47 5862 671746 354874 89595965
Wound 1372.63 13.47 5176 672432 297804 89653035
Constipation 1317.34 13.47 250 677358 280145 89670694
Hypotension 1271.13 13.47 424 677184 324973 89625866
Pericarditis 1253.18 13.47 4651 672957 265500 89685339
Toxicity to various agents 1244.00 13.47 310 677298 287536 89663303
Pain 1181.81 13.47 11991 665617 984350 88966489
Drug interaction 1178.73 13.47 306 677302 276147 89674692
Anaemia 1161.36 13.47 594 677014 352208 89598631
Arthralgia 1118.42 13.47 9763 667845 768759 89182080
Rheumatoid factor positive 1110.57 13.47 3308 674300 168342 89782497
Folliculitis 1098.49 13.47 3694 673914 200659 89750180
Musculoskeletal stiffness 1050.05 13.47 4696 672912 291836 89659003
Febrile neutropenia 1041 13.47 31 677577 158318 89792521
Hypersensitivity 1027.38 13.47 6356 671252 448321 89502518
Duodenal ulcer perforation 1006.76 13.47 3787 673821 217501 89733338
Completed suicide 981.57 13.47 21 677587 145037 89805802
Peripheral swelling 979.42 13.47 5848 671760 407258 89543581
Helicobacter infection 965.53 13.47 3801 673807 223049 89727790
Psoriatic arthropathy 947.78 13.47 3796 673812 224539 89726300
Impaired healing 931.24 13.47 3842 673766 230357 89720482
Discomfort 928.18 13.47 4287 673321 270048 89680791
Muscle injury 915.51 13.47 3155 674453 173499 89777340
Product dose omission issue 910.26 13.47 525 677083 291162 89659677
Irritable bowel syndrome 896.57 13.47 3493 674115 203955 89746884
C-reactive protein abnormal 888.59 13.47 2523 675085 124906 89825933
Lower respiratory tract infection 878.34 13.47 3958 673650 246701 89704138
Drug hypersensitivity 860.58 13.47 6172 671436 457437 89493402
Ill-defined disorder 839.78 13.47 3163 674445 181728 89769111
Gastrointestinal disorder 832.12 13.47 3962 673646 252725 89698114
Dehydration 800.85 13.47 230 677378 194217 89756622
Blister 797.05 13.47 3895 673713 251103 89699736
Malignant neoplasm progression 779.76 13.47 3 677605 106867 89843972
Hyponatraemia 762.01 13.47 63 677545 133475 89817364
Tremor 755.31 13.47 120 677488 153053 89797786
Disease progression 740.82 13.47 137 677471 156478 89794361
Rash 737.72 13.47 9135 668473 786965 89163874
Infusion related reaction 733.78 13.47 5480 672128 411300 89539539
Seizure 731.71 13.47 129 677479 152500 89798339
Somnolence 724.22 13.47 328 677280 208756 89742083
Neutropenia 674.56 13.47 424 677184 224480 89726359
Therapeutic product effect incomplete 667.89 13.47 3047 674561 190849 89759990
Urinary tract infection 667.33 13.47 781 676827 304851 89645988
Product use issue 663.09 13.47 4480 673128 325439 89625400
Sleep disorder due to general medical condition, insomnia type 660.85 13.47 2292 675316 126402 89824437
Infection 657.61 13.47 4797 672811 357297 89593542
Intentional overdose 641.11 13.47 12 677596 93822 89857017
Fall 635.99 13.47 1690 675918 480120 89470719
Mobility decreased 606.34 13.47 3570 674038 247164 89703675
Red blood cell sedimentation rate abnormal 598.77 13.47 819 676789 23385 89927454
Maternal exposure during pregnancy 583.63 13.47 4645 672963 355418 89595421
Cardiac arrest 573.30 13.47 59 677549 104876 89845963
Thrombocytopenia 570.83 13.47 435 677173 208290 89742549
Bradycardia 548.85 13.47 17 677591 83830 89867009
Cough 546.65 13.47 1218 676390 367744 89583095
Sepsis 529.54 13.47 346 677262 179468 89771371
Rheumatic fever 529.18 13.47 2409 675199 150712 89800127
Blood cholesterol increased 525.74 13.47 2997 674611 205015 89745824
Stomatitis 520.80 13.47 3678 673930 271020 89679819
Chest discomfort 512.98 13.47 196 677412 138169 89812670
C-reactive protein increased 496.11 13.47 2670 674938 178719 89772120
Condition aggravated 492.79 13.47 6697 670911 588848 89361991
Fibromyalgia 490.20 13.47 2924 674684 203345 89747494
Electrocardiogram QT prolonged 480.46 13.47 13 677595 72443 89878396
Red blood cell sedimentation rate increased 475.38 13.47 1529 676079 81066 89869773
Overdose 465.00 13.47 303 677305 157406 89793433
Vision blurred 462.29 13.47 126 677482 110167 89840672
Platelet count decreased 460.10 13.47 224 677384 136745 89814094
Suicide attempt 445.95 13.47 30 677578 75369 89875470
Inflammation 442.60 13.47 2560 675048 176032 89774807
Depressed level of consciousness 433.31 13.47 28 677580 72756 89878083
Dyspnoea 423.68 13.47 4379 673229 876576 89074263
COVID-19 420.77 13.47 385 677223 168458 89782381
Type 2 diabetes mellitus 419.90 13.47 2780 674828 200464 89750375
Loss of personal independence in daily activities 419.02 13.47 2071 675537 134034 89816805
Balance disorder 412.37 13.47 108 677500 96972 89853867
Osteoarthritis 412.10 13.47 2690 674918 193040 89757799
Hyperhidrosis 397.60 13.47 265 677343 136040 89814799
Tachycardia 395.92 13.47 357 677251 157316 89793523
Hyperkalaemia 395.80 13.47 22 677586 64942 89885897
Pulmonary embolism 394.34 13.47 245 677363 130575 89820264
Rheumatoid nodule 393.51 13.47 610 676998 19556 89931283
Hypokalaemia 393.23 13.47 247 677361 130869 89819970
Neutrophil count decreased 391.29 13.47 40 677568 71492 89879347
Cerebrovascular accident 391.24 13.47 218 677390 123315 89827524
Respiratory failure 391.18 13.47 198 677410 118220 89832619
Atrial fibrillation 389.41 13.47 260 677348 133351 89817488
Swollen joint count increased 384.41 13.47 1750 675858 109456 89841383
Liver injury 383.64 13.47 2384 675224 168183 89782656
Cognitive disorder 376.59 13.47 40 677568 69367 89881472
Myalgia 364.54 13.47 464 677144 174661 89776178
Epistaxis 359.09 13.47 96 677512 85029 89865810
Hypoglycaemia 357.45 13.47 49 677559 69799 89881040
Nausea 352.84 13.47 6014 671594 1104302 88846537
Hallucination 350.33 13.47 41 677567 65918 89884921
Dysphagia 350.03 13.47 202 677406 112076 89838763
Joint range of motion decreased 348.87 13.47 1964 675644 133679 89817160
Hypoxia 347.31 13.47 61 677547 72338 89878501
Pancytopenia 343.82 13.47 239 677369 120024 89830815
Sedation 338.26 13.47 4 677604 48167 89902672
Syncope 333.50 13.47 300 677308 132363 89818476
Agitation 331.96 13.47 52 677556 67046 89883793
Blood iron abnormal 331.07 13.47 260 677348 3760 89947079
Sinusitis 330.49 13.47 3970 673638 339118 89611721
Metabolic acidosis 329.71 13.47 22 677586 55654 89895185
Neuropathy peripheral 328.74 13.47 323 677285 136647 89814192
Blood glucose increased 328.72 13.47 150 677458 95096 89855743
Lactic acidosis 327.51 13.47 11 677597 50452 89900387
Wrong technique in product usage process 324.94 13.47 69 677539 71502 89879337
Injection site pain 322.88 13.47 499 677109 173200 89777639
Gastrointestinal haemorrhage 322.75 13.47 135 677473 90113 89860726
Dry skin 319.42 13.47 129 677479 87944 89862895
Renal failure 317.82 13.47 306 677302 130701 89820138
Anxiety 317.50 13.47 1216 676392 308556 89642283
White blood cell count decreased 317.43 13.47 473 677135 166636 89784203
Feeling abnormal 311.26 13.47 480 677128 166755 89784084
Flushing 307.52 13.47 138 677470 88353 89862486
Erythema 305.81 13.47 799 676809 228447 89722392
Pulmonary fibrosis 305.75 13.47 1600 676008 105903 89844936
Cardiac failure 304.62 13.47 224 677384 109272 89841567
Cardio-respiratory arrest 303.31 13.47 53 677555 63087 89887752
Knee arthroplasty 303.24 13.47 1330 676278 81852 89868987
Grip strength decreased 303.09 13.47 1434 676174 91142 89859697
Chills 302.27 13.47 324 677284 131657 89819182
Dizziness 301.92 13.47 2883 674725 586401 89364438
Haemoglobin decreased 301.27 13.47 465 677143 161491 89789348
Coma 277.40 13.47 98 677510 72534 89878305
Bone erosion 275.18 13.47 948 676660 52073 89898766
Intentional product use issue 274.87 13.47 2652 674956 214240 89736599
Facet joint syndrome 273.37 13.47 1455 676153 96934 89853905
Palpitations 271.52 13.47 375 677233 136353 89814486
Sleep disorder 269.76 13.47 2459 675149 195571 89755268
Night sweats 266.80 13.47 1763 675845 127003 89823836
Cardiac failure congestive 266.73 13.47 208 677400 98486 89852353
Abdominal pain 266.67 13.47 1797 675811 393924 89556915
Bone pain 263.13 13.47 69 677539 61914 89888925
Plasma cell myeloma 261.14 13.47 10 677598 40818 89910021
Unresponsive to stimuli 259.86 13.47 5 677603 38116 89912723
Pneumonia aspiration 258.58 13.47 11 677597 40929 89909910
Blood pressure decreased 253.73 13.47 121 677487 74774 89876065
Hyperglycaemia 251.01 13.47 40 677568 50930 89899909
Dysarthria 250.47 13.47 51 677557 54431 89896408
Inappropriate schedule of product administration 249.81 13.47 462 677146 149471 89801368
Mental status changes 249.58 13.47 23 677585 44656 89906183
General physical health deterioration 249.24 13.47 3883 673725 351232 89599607
Injury 248.54 13.47 2410 675198 194939 89755900
Lethargy 246.65 13.47 82 677526 63057 89887782
Encephalopathy 246.33 13.47 29 677579 46415 89904424
Finger deformity 245.50 13.47 668 676940 32229 89918610
Pleural effusion 244.33 13.47 286 677322 111705 89839134
Rhabdomyolysis 244.08 13.47 44 677564 51212 89899627
Haematochezia 239.57 13.47 115 677493 70798 89880041
Deep vein thrombosis 238.97 13.47 200 677408 91420 89859419
Drug ineffective for unapproved indication 237.80 13.47 100 677508 66544 89884295
Hip arthroplasty 234.70 13.47 1160 676448 75048 89875791
Premature delivery 233.45 13.47 14 677594 38748 89912091
Lip dry 232.49 13.47 1420 676188 99535 89851304
Orthostatic hypotension 232.40 13.47 22 677586 41805 89909034
Deformity 231.69 13.47 364 677244 11806 89939033
Pulmonary oedema 231.60 13.47 87 677521 61993 89888846
Nasopharyngitis 230.30 13.47 4299 673309 402805 89548034
Adverse event 229.69 13.47 1585 676023 115833 89835006
Colitis 229.39 13.47 118 677490 69824 89881015
International normalised ratio increased 228.85 13.47 39 677569 47277 89903562
Rash erythematous 228.62 13.47 100 677508 65004 89885835
Tenosynovitis 226.74 13.47 398 677210 14169 89936670
Ascites 225.14 13.47 42 677566 47698 89903141
Intentional product misuse 224.73 13.47 203 677405 89401 89861438
Disturbance in attention 223.12 13.47 41 677567 47068 89903771
Suicidal ideation 220.21 13.47 140 677468 73715 89877124
Oedema peripheral 219.92 13.47 1085 676523 256830 89694009
Oropharyngeal pain 219.72 13.47 325 677283 114862 89835977
Musculoskeletal pain 218.91 13.47 2098 675510 169153 89781686
Restlessness 217.89 13.47 12 677596 35708 89915131
Multiple organ dysfunction syndrome 217.20 13.47 120 677488 68216 89882623
Myelosuppression 215.74 13.47 66 677542 53525 89897314
Dysgeusia 211.10 13.47 65 677543 52495 89898344
Bursitis 209.80 13.47 1693 675915 129961 89820878
Incorrect dose administered 208.70 13.47 170 677438 78760 89872079
Respiratory arrest 206.95 13.47 10 677598 33301 89917538
Diarrhoea 205.68 13.47 5400 672208 933790 89017049
Foot deformity 204.78 13.47 937 676671 58714 89892125
Intentional self-injury 203.48 13.47 3 677605 29331 89921508
Aphasia 203.32 13.47 37 677571 42775 89908064
Gait inability 200.60 13.47 1821 675787 144635 89806204
Musculoskeletal disorder 199.80 13.47 478 677130 21291 89929548
Chronic obstructive pulmonary disease 198.98 13.47 156 677452 73673 89877166
Blood creatinine increased 198.35 13.47 281 677327 101105 89849734
Breast cancer stage III 197.10 13.47 1192 676416 83255 89867584
Urinary retention 196.66 13.47 25 677583 37719 89913120
Drug tolerance decreased 195.98 13.47 607 677001 31523 89919316
Oxygen saturation decreased 194.72 13.47 314 677294 107169 89843670
Full blood count decreased 194.35 13.47 6 677602 29683 89921156
Skin exfoliation 194.03 13.47 135 677473 67778 89883061
Cytokine release syndrome 193.45 13.47 3 677605 27970 89922869
Heart rate increased 193.33 13.47 342 677266 112560 89838279
Respiratory distress 193.06 13.47 30 677578 38916 89911923
Adverse reaction 192.18 13.47 573 677035 29139 89921700
Granuloma skin 189.02 13.47 309 677299 10371 89940468
Therapy interrupted 188.98 13.47 69 677539 50039 89900800
Dyskinesia 188.42 13.47 25 677583 36509 89914330
Dyspnoea exertional 188.27 13.47 158 677450 72130 89878709
Hypervolaemia 188.06 13.47 15 677593 32742 89918097
Drug withdrawal syndrome 187.32 13.47 6 677602 28717 89922122
Blood parathyroid hormone decreased 186.57 13.47 331 677277 11885 89938954
Thrombosis 186.03 13.47 164 677444 73087 89877752
Sciatica 185.13 13.47 1346 676262 100036 89850803
Angioedema 183.98 13.47 130 677478 64746 89886093
Disorientation 183.68 13.47 51 677557 44063 89906776
Panniculitis 183.66 13.47 362 677246 14096 89936743
Macular degeneration 179.92 13.47 33 677575 37937 89912902
Blood potassium decreased 179.52 13.47 66 677542 47661 89903178
Vomiting 178.62 13.47 4509 673099 783784 89167055
Swelling face 178.25 13.47 207 677401 81145 89869694
Urinary incontinence 177.25 13.47 33 677575 37533 89913306
Cerebral haemorrhage 177.15 13.47 24 677584 34498 89916341
Liver function test increased 175.23 13.47 1161 676447 83694 89867145
Metastases to liver 174.72 13.47 10 677598 28797 89922042
Haematoma 174.49 13.47 39 677569 39009 89911830
Altered state of consciousness 174.09 13.47 17 677591 31515 89919324
Melaena 172.04 13.47 27 677581 34770 89916069
Generalised tonic-clonic seizure 170.50 13.47 28 677580 34875 89915964
Chronic kidney disease 170.14 13.47 81 677527 50110 89900729
Blood calcium decreased 170.03 13.47 15 677593 30167 89920672
Peripheral venous disease 168.95 13.47 1141 676467 82780 89868059
Arthritis 168.74 13.47 1954 675654 165361 89785478
Back injury 168.02 13.47 743 676865 45879 89904960
Deafness transitory 167.95 13.47 132 677476 1911 89948928
Full blood count abnormal 166.70 13.47 35 677573 36562 89914277
Haemorrhage 164.78 13.47 165 677443 69204 89881635
Vertigo 164.74 13.47 167 677441 69644 89881195
Pneumonia 164.67 13.47 3577 674031 634482 89316357
Device dislocation 163.67 13.47 21 677587 31461 89919378
Dysuria 163.22 13.47 46 677562 39355 89911484
Influenza 163.18 13.47 516 677092 138748 89812091
Depressed mood 162.80 13.47 86 677522 50136 89900703
Osteoporosis 161.80 13.47 1256 676352 95275 89855564
Drug level increased 161.39 13.47 12 677596 27750 89923089
Acute respiratory failure 160.33 13.47 60 677548 42858 89907981
Asthenia 159.09 13.47 2921 674687 530830 89420009
Mucosal inflammation 158.81 13.47 119 677489 57506 89893333
Nail disorder 158.26 13.47 865 676743 58202 89892637
Wound infection 158.11 13.47 1347 676261 105055 89845784
Accidental exposure to product 156.98 13.47 60 677548 42306 89908533
Lymphocyte count decreased 156.64 13.47 35 677573 35015 89915824
Blood pressure increased 156.60 13.47 850 676758 196367 89754472
Hypomagnesaemia 156.13 13.47 37 677571 35551 89915288
Dysphonia 155.71 13.47 145 677463 62939 89887900
Paraesthesia oral 155.54 13.47 25 677583 31634 89919205
Ejection fraction decreased 153.61 13.47 11 677597 26242 89924597
Product label confusion 151.91 13.47 445 677163 22405 89928434
Rheumatoid lung 151.78 13.47 170 677438 3933 89946906
Cardiac disorder 150.96 13.47 122 677486 56750 89894089
Irritability 150.79 13.47 40 677568 35622 89915217
Foetal exposure during pregnancy 149.32 13.47 67 677541 42908 89907931
Flatulence 149.31 13.47 61 677547 41306 89909533
Adverse drug reaction 149.22 13.47 1430 676178 115271 89835568
Renal impairment 148.59 13.47 357 677251 105064 89845775
Metastases to bone 148.34 13.47 11 677597 25494 89925345
Aggression 148.23 13.47 14 677594 26654 89924185
Tinnitus 146.96 13.47 69 677539 43033 89907806
Toxic epidermal necrolysis 146.34 13.47 32 677576 32496 89918343
Hepatic function abnormal 146.06 13.47 82 677526 46206 89904633
Presyncope 145.72 13.47 30 677578 31775 89919064
Pericardial effusion 145.33 13.47 47 677561 36786 89914053
Fluid retention 144.44 13.47 274 677334 87817 89863022
Joint destruction 144.44 13.47 312 677296 12975 89937864
Lip swelling 144.20 13.47 54 677554 38556 89912283
Burning sensation 143.87 13.47 157 677451 63295 89887544
Contusion 143.63 13.47 2658 674950 248558 89702281
Hypercholesterolaemia 143.51 13.47 1265 676343 99627 89851212
Ventricular tachycardia 142.73 13.47 11 677597 24697 89926142
Cholelithiasis 142.69 13.47 110 677498 52396 89898443
Food allergy 142.62 13.47 13 677595 25465 89925374
Abortion spontaneous 142.19 13.47 117 677491 53939 89896900
Drug reaction with eosinophilia and systemic symptoms 140.41 13.47 72 677536 42686 89908153
Therapeutic response decreased 140.27 13.47 1149 676459 88580 89862259
Hallucination, visual 140.10 13.47 8 677600 23084 89927755
Blood bilirubin increased 140.08 13.47 75 677533 43395 89907444
Abnormal behaviour 139.91 13.47 7 677601 22621 89928218
Lung disorder 137.80 13.47 1720 675888 148163 89802676
Myocardial infarction 137.69 13.47 374 677234 105598 89845241
Weight decreased 137.60 13.47 2005 675603 377905 89572934
Therapy cessation 137.24 13.47 50 677558 36311 89914528
Back pain 137.21 13.47 1613 675995 315562 89635277
Blood urea increased 136.66 13.47 30 677578 30383 89920456
Psychotic disorder 135.96 13.47 33 677575 31197 89919642
Pancreatitis acute 135.83 13.47 36 677572 32079 89918760
Haematuria 135.36 13.47 46 677562 34891 89915948
Illness 135.23 13.47 254 677354 81715 89869124
Swollen tongue 134.43 13.47 89 677519 45867 89904972
Deep vein thrombosis postoperative 134.41 13.47 949 676659 69860 89880979
Live birth 134.07 13.47 1032 676576 78075 89872764
Weight increased 134.01 13.47 4081 673527 413846 89536993
Coordination abnormal 134.00 13.47 6 677602 21350 89929489
Hemiparesis 133.95 13.47 36 677572 31783 89919056
X-ray abnormal 133.89 13.47 683 676925 44741 89906098
Pulmonary hypertension 133.21 13.47 76 677532 42447 89908392
Dermatitis atopic 131.32 13.47 12 677596 23460 89927379
Eye pain 131.28 13.47 84 677524 44084 89906755
Inappropriate antidiuretic hormone secretion 131.20 13.47 3 677605 19502 89931337
Nasal congestion 131.10 13.47 266 677342 83148 89867691
Procedural pain 130.86 13.47 43 677565 33317 89917522
Withdrawal syndrome 130.19 13.47 10 677598 22514 89928325
Product administration error 129.51 13.47 21 677587 26402 89924437
Clostridium difficile colitis 129.17 13.47 22 677586 26684 89924155
Agranulocytosis 128.98 13.47 50 677558 34952 89915887
Dementia 128.79 13.47 14 677594 23847 89926992
Muscle twitching 128.62 13.47 15 677593 24187 89926652
Circulatory collapse 128.53 13.47 17 677591 24887 89925952
Skin necrosis 128.40 13.47 346 677262 16595 89934244
Sinus tachycardia 128.37 13.47 28 677580 28485 89922354
Hepatic cytolysis 128.24 13.47 36 677572 30880 89919959
Arrhythmia 127.90 13.47 79 677529 42253 89908586
Lacrimation increased 127.20 13.47 24 677584 27038 89923801
Cholestasis 127.05 13.47 56 677552 36243 89914596
Limb deformity 126.91 13.47 156 677452 3996 89946843
Pallor 125.57 13.47 49 677559 34116 89916723
Abdominal pain lower 125.43 13.47 35 677573 30142 89920697
Right ventricular failure 125.28 13.47 4 677604 19201 89931638
Upper gastrointestinal haemorrhage 125.25 13.47 13 677595 22963 89927876
Vaginal haemorrhage 124.99 13.47 39 677569 31232 89919607
Blood sodium decreased 124.56 13.47 27 677581 27586 89923253
Sleep apnoea syndrome 124.40 13.47 41 677567 31706 89919133
Pollakiuria 123.53 13.47 46 677562 32959 89917880
Lower limb fracture 122.51 13.47 1069 676539 83944 89866895
Hot flush 122.28 13.47 159 677449 59329 89891510
Neutropenic sepsis 121.14 13.47 3 677605 18127 89932712
Haemoptysis 120.48 13.47 49 677559 33271 89917568
Cellulitis 120.43 13.47 320 677288 91017 89859822
Vaginal discharge 120.41 13.47 6 677602 19458 89931381
Cardiogenic shock 118.69 13.47 20 677588 24448 89926391
Productive cough 117.52 13.47 250 677358 76813 89874026
Head injury 117.52 13.47 43 677565 31145 89919694
Pyrexia 117.34 13.47 3905 673703 656580 89294259
Obstructive airways disorder 117.29 13.47 25 677583 25844 89924995
Acute myocardial infarction 117.20 13.47 57 677551 34833 89916006
Disability 116.17 13.47 607 677001 40138 89910701
Obesity 115.80 13.47 1253 676355 104254 89846585
Bacteraemia 115.62 13.47 15 677593 22285 89928554
Musculoskeletal deformity 115.36 13.47 103 677505 1795 89949044
Myoclonus 115.19 13.47 7 677601 19161 89931678
Blood creatine phosphokinase increased 115.18 13.47 55 677553 33968 89916871
Acute myeloid leukaemia 114.28 13.47 11 677597 20629 89930210
Device issue 114.24 13.47 39 677569 29498 89921341
Transient ischaemic attack 114.12 13.47 93 677515 43083 89907756
Diabetic ketoacidosis 113.96 13.47 22 677586 24385 89926454
Bone marrow failure 113.90 13.47 49 677559 32172 89918667
Skin ulcer 113.76 13.47 702 676906 49373 89901466
Joint stiffness 112.79 13.47 982 676626 77060 89873779
Panic attack 112.57 13.47 29 677579 26336 89924503
Onychomycosis 112.27 13.47 565 677043 36811 89914028
Chronic sinusitis 112.10 13.47 21 677587 23781 89927058
Infusion site pain 110.67 13.47 10 677598 19728 89931111
Creatinine renal clearance decreased 110.35 13.47 8 677600 18891 89931948
Autoimmune disorder 110.05 13.47 964 676644 75780 89875059
Stevens-Johnson syndrome 109.85 13.47 41 677567 29335 89921504
Leukocytosis 109.75 13.47 47 677561 30943 89919896
Rhinorrhoea 109.32 13.47 319 677289 87997 89862842
Eczema 108.99 13.47 141 677467 52729 89898110
Sinus bradycardia 108.93 13.47 4 677604 16948 89933891
Hospitalisation 108.46 13.47 540 677068 127560 89823279
Product prescribing error 107.91 13.47 45 677563 30100 89920739
Septic shock 107.85 13.47 299 677309 83861 89866978
Chest pain 106.14 13.47 1715 675893 317930 89632909
Asthma 106.05 13.47 1228 676380 240932 89709907
Female genital tract fistula 105.96 13.47 7 677601 17861 89932978
Nodule 105.96 13.47 438 677170 26248 89924591
Emotional distress 105.89 13.47 72 677536 36590 89914249
Intestinal obstruction 105.81 13.47 74 677534 37057 89913782
Hallucination, auditory 105.40 13.47 3 677605 15972 89934867
Neurotoxicity 105.35 13.47 17 677591 21450 89929389
Upper respiratory tract infection 105.19 13.47 547 677061 127771 89823068
Dislocation of vertebra 105.00 13.47 748 676860 55220 89895619
Cerebral infarction 104.82 13.47 34 677574 26562 89924277
Status epilepticus 104.66 13.47 10 677598 18864 89931975
Sinus disorder 104.47 13.47 64 677544 34383 89916456
Adjustment disorder with depressed mood 104.45 13.47 755 676853 55998 89894841
Pain in jaw 104.14 13.47 123 677485 47862 89902977
Metastases to central nervous system 103.66 13.47 7 677601 17535 89933304
Skin discolouration 103.43 13.47 107 677501 44208 89906631
Eye swelling 103.38 13.47 45 677563 29341 89921498
Tuberculin test positive 102.80 13.47 133 677475 3592 89947247
Diplopia 102.57 13.47 43 677565 28671 89922168
Hepatitis 101.65 13.47 889 676719 69850 89880989
Injection site erythema 101.20 13.47 386 677222 98116 89852723
Speech disorder 100.93 13.47 115 677493 45470 89905369
Mental disorder 100.89 13.47 58 677550 32260 89918579
Face oedema 100.81 13.47 25 677583 23293 89927546
Transfusion 100.41 13.47 8 677600 17480 89933359
Onychomadesis 100.23 13.47 638 676970 45360 89905479
Ear pain 100.14 13.47 757 676851 56945 89893894
Cystitis 99.61 13.47 219 677389 66499 89884340
Disseminated intravascular coagulation 99.33 13.47 20 677588 21518 89929321
Influenza like illness 99.17 13.47 292 677316 80319 89870520
Sensory loss 99.12 13.47 10 677598 18065 89932774
Foot operation 98.57 13.47 212 677396 8789 89942050
Dystonia 98.54 13.47 7 677601 16812 89934027
Eosinophilia 98.33 13.47 45 677563 28488 89922351
Device difficult to use 97.94 13.47 9 677599 17516 89933323
Electrolyte imbalance 97.84 13.47 28 677580 23717 89927122
Impaired quality of life 97.78 13.47 26 677582 23118 89927721
No adverse event 97.56 13.47 228 677380 67754 89883085
Small intestinal obstruction 97.34 13.47 20 677588 21214 89929625
Pulmonary arterial hypertension 97.17 13.47 37 677571 26150 89924689
Product substitution issue 96.10 13.47 11 677597 17997 89932842
Renal disorder 95.84 13.47 85 677523 37774 89913065
Tachypnoea 95.78 13.47 21 677587 21288 89929551
Ischaemic stroke 95.37 13.47 24 677584 22142 89928697
Accidental overdose 95.26 13.47 46 677562 28227 89922612
Red blood cell sedimentation rate 95.23 13.47 144 677464 4514 89946325
Clostridium difficile infection 94.64 13.47 79 677529 36166 89914673
Liver disorder 94.61 13.47 1351 676257 119918 89830921
Angina pectoris 94.32 13.47 92 677516 39068 89911771
Ocular hyperaemia 94.16 13.47 69 677539 33729 89917110
Complication associated with device 94.12 13.47 16 677592 19433 89931406
Premature baby 93.77 13.47 35 677573 25042 89925797
Metastases to lung 92.71 13.47 7 677601 15984 89934855
Respiratory tract infection 92.32 13.47 189 677419 58889 89891950
Blood glucose decreased 92.25 13.47 30 677578 23399 89927440
Shock 92.22 13.47 50 677558 28728 89922111
Mitral valve incompetence 92.00 13.47 27 677581 22497 89928342
Gastritis 90.64 13.47 107 677501 41646 89909193
Malnutrition 90.40 13.47 15 677593 18543 89932296
Loss of consciousness 90.25 13.47 645 676963 139593 89811246
Hypothyroidism 89.96 13.47 162 677446 52965 89897874
Hypothermia 89.78 13.47 7 677601 15568 89935271
Diabetes mellitus inadequate control 89.04 13.47 16 677592 18668 89932171
Mydriasis 88.68 13.47 6 677602 15006 89935833
Mania 88.52 13.47 4 677604 14120 89936719
Shoulder arthroplasty 88.33 13.47 131 677477 4035 89946804
Enthesopathy 87.92 13.47 208 677400 9196 89941643
Anuria 87.30 13.47 6 677602 14812 89936027
Poisoning 87.26 13.47 7 677601 15210 89935629
Blepharospasm 87.19 13.47 711 676897 54734 89896105
Hepatic failure 87.11 13.47 101 677507 39627 89911212
Nightmare 87.00 13.47 27 677581 21698 89929141
Incontinence 86.92 13.47 3 677605 13432 89937407
Extrapyramidal disorder 86.90 13.47 10 677598 16293 89934546
Haemorrhage intracranial 86.88 13.47 7 677601 15155 89935684
Subdural haematoma 86.77 13.47 11 677597 16634 89934205
Respiratory disorder 86.70 13.47 802 676806 64014 89886825
Muscle rigidity 86.68 13.47 5 677603 14304 89936535
Eye pruritus 86.55 13.47 55 677553 28972 89921867
Throat irritation 86.55 13.47 144 677464 48551 89902288
Left ventricular dysfunction 86.25 13.47 6 677602 14663 89936176
Joint effusion 85.86 13.47 333 677275 19377 89931462
Rectal haemorrhage 85.81 13.47 323 677285 82421 89868418
Labelled drug-drug interaction medication error 85.64 13.47 6 677602 14576 89936263
Cytomegalovirus infection 85.56 13.47 46 677562 26556 89924283
Nervousness 85.56 13.47 77 677531 33979 89916860
Blood magnesium decreased 85.23 13.47 9 677599 15684 89935155
Pulmonary toxicity 84.88 13.47 233 677375 11298 89939541
C-reactive protein 84.45 13.47 460 677148 30907 89919932
Rash macular 84.12 13.47 62 677546 30218 89920621
Hypersomnia 84.02 13.47 28 677580 21503 89929336
Cyanosis 83.83 13.47 21 677587 19434 89931405
Haematemesis 82.66 13.47 78 677530 33648 89917191
Oral mucosal exfoliation 82.24 13.47 83 677525 1697 89949142
Respiratory depression 81.91 13.47 10 677598 15565 89935274
Joint laxity 80.75 13.47 99 677509 2529 89948310
Injection site swelling 80.13 13.47 208 677400 59631 89891208
Paranoia 79.78 13.47 4 677604 12904 89937935
Blindness 79.69 13.47 50 677558 26518 89924321
Aplastic anaemia 79.28 13.47 5 677603 13264 89937575
Infusion site erythema 79.20 13.47 6 677602 13664 89937175
Hemiplegia 78.85 13.47 13 677595 16147 89934692
Bronchitis 78.52 13.47 747 676861 152180 89798659
Hypocalcaemia 78.40 13.47 122 677486 42246 89908593
Impaired work ability 78.15 13.47 319 677289 19007 89931832
Myopathy 78.13 13.47 6 677602 13512 89937327
Arthrodesis 77.64 13.47 104 677504 2908 89947931
Dry mouth 77.62 13.47 1863 675745 182196 89768643
Foetal death 77.36 13.47 29 677579 20694 89930145
Premature labour 77.14 13.47 6 677602 13370 89937469
Ileus 77.07 13.47 15 677593 16531 89934308
Hypophosphataemia 76.99 13.47 10 677598 14844 89935995
Blood calcium increased 76.95 13.47 3 677605 12055 89938784
Rheumatoid factor negative 76.62 13.47 51 677557 560 89950279
Rhinitis allergic 76.55 13.47 16 677592 16769 89934070
Ventricular fibrillation 76.41 13.47 8 677600 14036 89936803
Retching 76.38 13.47 24 677584 19135 89931704
Fear 75.49 13.47 16 677592 16606 89934233
Prescribed underdose 75.07 13.47 875 676733 74144 89876695
Fatigue 74.89 13.47 9782 667826 1144241 88806598
Therapeutic response unexpected 74.63 13.47 35 677573 21845 89928994
Sneezing 74.48 13.47 68 677540 29801 89921038
Drug tolerance 73.46 13.47 297 677311 17619 89933220
Motor dysfunction 73.32 13.47 26 677582 19204 89931635
Viral infection 73.11 13.47 123 677485 41291 89909548
Visual acuity reduced 73.10 13.47 42 677566 23368 89927471
Anal incontinence 72.94 13.47 16 677592 16214 89934625
Posterior reversible encephalopathy syndrome 72.78 13.47 38 677570 22301 89928538
Caesarean section 72.77 13.47 24 677584 18553 89932286
Retinal toxicity 72.56 13.47 70 677538 1352 89949487
Gastrointestinal pain 72.36 13.47 216 677392 10990 89939849
Tricuspid valve incompetence 72.21 13.47 18 677590 16713 89934126
Mental impairment 72.14 13.47 18 677590 16702 89934137
Headache 72.04 13.47 5515 672093 857231 89093608
Acute respiratory distress syndrome 71.90 13.47 65 677543 28621 89922218
Supraventricular tachycardia 71.63 13.47 17 677591 16319 89934520
Injection site mass 71.34 13.47 38 677570 22052 89928787
Infusion site swelling 71.29 13.47 4 677604 11716 89939123
Ataxia 71.22 13.47 23 677585 18019 89932820
Body temperature increased 71.19 13.47 575 677033 44135 89906704
Troponin increased 71.16 13.47 8 677600 13273 89937566
Polyarthritis 71.14 13.47 299 677309 18051 89932788
Abdominal pain upper 71.09 13.47 3104 674504 329570 89621269
Product administration interrupted 70.94 13.47 6 677602 12486 89938353
Breast cancer metastatic 69.89 13.47 14 677594 15118 89935721
Jaundice 69.87 13.47 84 677524 32433 89918406
Hip fracture 69.44 13.47 87 677521 32990 89917849
Myelodysplastic syndrome 68.93 13.47 35 677573 20868 89929971
Hyperbilirubinaemia 68.47 13.47 11 677597 13925 89936914
Nasal polyps 68.45 13.47 3 677605 10877 89939962
International normalised ratio fluctuation 68.09 13.47 99 677509 2994 89947845
Eye irritation 67.61 13.47 93 677515 33885 89916954
Device related infection 67.58 13.47 56 677552 25730 89925109
Multiple sclerosis 67.52 13.47 65 677543 27775 89923064
Acidosis 67.42 13.47 8 677600 12728 89938111
Ankylosing spondylitis 67.41 13.47 234 677374 12899 89937940
Surgical failure 67.31 13.47 57 677551 922 89949917
Ulcer 67.31 13.47 449 677159 32433 89918406
Skin haemorrhage 67.27 13.47 38 677570 21342 89929497
Spinal column injury 67.24 13.47 82 677526 2083 89948756
Therapy partial responder 66.78 13.47 41 677567 22002 89928837
Tubulointerstitial nephritis 66.46 13.47 55 677553 25288 89925551
Muscle spasticity 66.20 13.47 472 677136 34850 89915989
Toxic skin eruption 66.11 13.47 18 677590 15756 89935083
Confusional state 65.99 13.47 3525 674083 382680 89568159
Coeliac disease 65.85 13.47 564 677044 44046 89906793
Tardive dyskinesia 65.66 13.47 4 677604 10926 89939913
Pruritus allergic 65.65 13.47 73 677535 1675 89949164
Faeces discoloured 65.51 13.47 39 677569 21281 89929558
Faecaloma 65.22 13.47 3 677605 10428 89940411
Colitis ischaemic 64.75 13.47 8 677600 12338 89938501
Lymphopenia 64.67 13.47 46 677562 22835 89928004
Glomerular filtration rate decreased 64.38 13.47 23 677585 16909 89933930
Therapy non-responder 64.25 13.47 1405 676203 135299 89815540
Head discomfort 64.16 13.47 21 677587 16312 89934527
Renal tubular necrosis 64.11 13.47 15 677593 14540 89936299
Loose body in joint 64.09 13.47 65 677543 1337 89949502
Exposure via skin contact 64.06 13.47 4 677604 10701 89940138
Haemorrhoids 63.99 13.47 63 677545 26639 89924200
Road traffic accident 63.97 13.47 1146 676462 106480 89844359
Lymphadenopathy 63.71 13.47 156 677452 45619 89905220
Device malfunction 63.58 13.47 39 677569 20938 89929901
Delusion 63.52 13.47 13 677595 13827 89937012
Prescribed overdose 63.25 13.47 1054 676554 96571 89854268
Hepatic encephalopathy 63.07 13.47 13 677595 13759 89937080
Acute generalised exanthematous pustulosis 62.62 13.47 13 677595 13690 89937149
Exostosis 62.50 13.47 640 676968 52494 89898345
Stress cardiomyopathy 62.43 13.47 12 677596 13343 89937496
Systemic lupus erythematosus rash 62.37 13.47 83 677525 2306 89948533
Brain oedema 62.15 13.47 26 677582 17359 89933480
Vascular device infection 62.06 13.47 8 677600 11944 89938895
Hypoacusis 61.93 13.47 70 677538 27780 89923059
Urine output decreased 61.80 13.47 10 677598 12593 89938246
Shock haemorrhagic 61.68 13.47 9 677599 12236 89938603
Affect lability 61.45 13.47 29 677579 18034 89932805
Hyperthyroidism 61.37 13.47 30 677578 18280 89932559
Electrocardiogram abnormal 61.17 13.47 4 677604 10294 89940545
Oral candidiasis 61.03 13.47 107 677501 35348 89915491
Apathy 60.82 13.47 6 677602 11034 89939805
Atrioventricular block complete 60.77 13.47 3 677605 9808 89941031
Arterial occlusive disease 60.76 13.47 10 677598 12436 89938403
Hepatotoxicity 60.69 13.47 566 677042 45276 89905563
Haemodynamic instability 60.61 13.47 8 677600 11731 89939108
Thirst 60.50 13.47 23 677585 16272 89934567
Osteonecrosis of jaw 60.33 13.47 126 677482 38977 89911862
Rash papular 60.10 13.47 39 677569 20316 89930523
Retinitis 59.83 13.47 492 677116 37966 89912873
Hyperlipidaemia 59.77 13.47 50 677558 22866 89927973
Ventricular extrasystoles 59.67 13.47 13 677595 13237 89937602
Bloody discharge 59.66 13.47 79 677529 2184 89948655
Tuberculosis 59.62 13.47 218 677390 12331 89938508
Mood altered 59.13 13.47 27 677581 17117 89933722
Tumour lysis syndrome 59.04 13.47 7 677601 11145 89939694
Suspected suicide 59.03 13.47 3 677605 9565 89941274
Hepatocellular injury 58.89 13.47 78 677530 28880 89921959
Bone swelling 58.78 13.47 69 677539 1682 89949157
Ankle arthroplasty 58.56 13.47 88 677520 2743 89948096
Hypotonia 58.49 13.47 8 677600 11418 89939421
Red cell distribution width decreased 58.42 13.47 77 677531 2119 89948720
Amenorrhoea 58.16 13.47 9 677599 11713 89939126
Peritonitis 57.85 13.47 38 677570 19667 89931172
Sinus congestion 57.70 13.47 72 677536 27352 89923487
Emotional disorder 57.66 13.47 20 677588 14977 89935862
Gestational diabetes 57.65 13.47 6 677602 10576 89940263
Restless legs syndrome 57.42 13.47 50 677558 22420 89928419
Myocarditis 57.40 13.47 16 677592 13790 89937049
Abnormal dreams 57.34 13.47 8 677600 11249 89939590
Gangrene 57.25 13.47 13 677595 12863 89937976
Eructation 57.20 13.47 7 677601 10875 89939964
Feeling cold 56.86 13.47 73 677535 27392 89923447
Upper-airway cough syndrome 56.80 13.47 21 677587 15114 89935725
Urticaria 56.76 13.47 2871 674737 309863 89640976
Oesophagitis 56.70 13.47 29 677579 17220 89933619
Complication of device insertion 56.64 13.47 6 677602 10430 89940409
Decreased appetite 56.60 13.47 2271 675337 374269 89576570
Eosinophil count increased 56.59 13.47 14 677594 13067 89937772
Hypoalbuminaemia 56.47 13.47 24 677584 15873 89934966
Throat tightness 56.38 13.47 83 677525 29401 89921438
Chromaturia 56.33 13.47 37 677571 19150 89931689
Purpura 56.31 13.47 20 677588 14758 89936081
Cardiomegaly 56.23 13.47 36 677572 18889 89931950
Neuralgia 56.12 13.47 93 677515 31407 89919432
Pain of skin 55.98 13.47 25 677583 16057 89934782
Atelectasis 55.77 13.47 60 677548 24349 89926490
Coagulopathy 55.75 13.47 55 677553 23234 89927605
Product storage error 55.51 13.47 42 677566 20199 89930640
Central nervous system lesion 55.44 13.47 10 677598 11636 89939203
Unevaluable event 55 13.47 217 677391 54631 89896208
Immune thrombocytopenia 54.38 13.47 16 677592 13310 89937529
Generalised oedema 54.25 13.47 38 677570 19015 89931824
Ovarian cyst 54.17 13.47 31 677577 17287 89933552
Drug resistance 54.15 13.47 90 677518 30359 89920480
Nephropathy toxic 54.08 13.47 14 677594 12674 89938165
Cholecystitis 54.03 13.47 30 677578 17010 89933829
Device breakage 53.53 13.47 19 677589 14025 89936814
Physical disability 53.40 13.47 102 677506 3879 89946960
Subarachnoid haemorrhage 53.28 13.47 34 677574 17870 89932969
Lupus vulgaris 53.12 13.47 543 677065 44516 89906323
Oliguria 53.07 13.47 8 677600 10616 89940223
Insurance issue 53.06 13.47 9 677599 10949 89939890
Coronary artery disease 53.01 13.47 107 677501 33516 89917323
Hiatus hernia 52.93 13.47 67 677541 25294 89925545
Renal injury 52.84 13.47 7 677601 10236 89940603
Vascular access complication 52.78 13.47 77 677531 2336 89948503
Joint injury 52.50 13.47 421 677187 32243 89918596
Dermatitis contact 52.49 13.47 18 677590 13577 89937262
Cholecystitis chronic 52.44 13.47 6 677602 9820 89941019
Pemphigoid 52.19 13.47 4 677604 9022 89941817
Bacterial infection 52.05 13.47 59 677549 23385 89927454
Drug eruption 51.92 13.47 447 677161 34960 89915879
End stage renal disease 51.90 13.47 3 677605 8568 89942271
Lung neoplasm malignant 51.84 13.47 63 677545 24210 89926629
Hereditary angioedema 51.83 13.47 5 677603 9360 89941479
Metastases to lymph nodes 51.57 13.47 12 677596 11677 89939162
Jaundice cholestatic 51.48 13.47 7 677601 10036 89940803
Atrioventricular block first degree 51.47 13.47 3 677605 8508 89942331
Initial insomnia 51.45 13.47 5 677603 9305 89941534
Proteinuria 51.29 13.47 59 677549 23232 89927607
Radiculopathy 51.26 13.47 38 677570 18467 89932372
Lower gastrointestinal haemorrhage 51.24 13.47 4 677604 8888 89941951
Infusion site reaction 51.11 13.47 279 677329 18760 89932079
Hypoaesthesia 51.09 13.47 2855 674753 311355 89639484
Treatment noncompliance 51.02 13.47 206 677402 51521 89899318
Eyelid oedema 50.58 13.47 12 677596 11522 89939317
Blood lactic acid increased 50.44 13.47 4 677604 8774 89942065
Musculoskeletal chest pain 50.34 13.47 62 677546 23688 89927151
Basal cell carcinoma 50.26 13.47 424 677184 32965 89917874
Therapy change 50.13 13.47 3 677605 8319 89942520
Extra dose administered 50.11 13.47 5 677603 9113 89941726
Muscle tightness 49.84 13.47 19 677589 13420 89937419
Pre-eclampsia 49.43 13.47 11 677597 11037 89939802
Drug level decreased 49.36 13.47 7 677601 9723 89941116
Muscle spasms 49.21 13.47 1470 676138 250413 89700426
Rash maculo-papular 49.10 13.47 150 677458 40783 89910056
Acne 49.10 13.47 86 677522 28421 89922418
Mean platelet volume decreased 49.05 13.47 83 677525 2867 89947972
Progressive multifocal leukoencephalopathy 49.00 13.47 28 677580 15627 89935212
Poor quality sleep 48.72 13.47 68 677540 24625 89926214
Neutrophil count increased 48.52 13.47 44 677564 19346 89931493
Glycosylated haemoglobin increased 48.48 13.47 28 677580 15534 89935305
Increased appetite 48.24 13.47 14 677594 11751 89939088
Skin laceration 48.14 13.47 75 677533 25960 89924879
Rib fracture 48.07 13.47 77 677531 26358 89924481
Atrioventricular block 48.02 13.47 5 677603 8810 89942029
Enterocolitis 47.84 13.47 10 677598 10480 89940359
Gait disturbance 47.78 13.47 2394 675214 258102 89692737
Blood loss anaemia 47.64 13.47 9 677599 10131 89940708
Heavy menstrual bleeding 47.42 13.47 50 677558 20480 89930359
Blood triglycerides increased 46.96 13.47 22 677586 13739 89937100
Lymphoedema 46.91 13.47 22 677586 13731 89937108
Acute hepatic failure 46.67 13.47 60 677548 22501 89928338
Hypertension 46.56 13.47 3999 673609 453533 89497306
Acute pulmonary oedema 46.09 13.47 8 677600 9572 89941267
Skin irritation 46.03 13.47 22 677586 13581 89937258
Investigation abnormal 45.76 13.47 70 677538 2217 89948622
Thrombotic microangiopathy 45.35 13.47 31 677577 15712 89935127
Unintended pregnancy 45.26 13.47 3 677605 7634 89943205
Failure to thrive 45.23 13.47 5 677603 8406 89942433
Sensory disturbance 44.87 13.47 30 677578 15383 89935456
Escherichia infection 44.86 13.47 32 677576 15863 89934976
Infusion site extravasation 44.79 13.47 11 677597 10317 89940522
Injection site haemorrhage 44.74 13.47 90 677518 28228 89922611
Cardiomyopathy 44.70 13.47 51 677557 20155 89930684
Mean cell volume decreased 44.69 13.47 102 677506 4404 89946435
Exercise tolerance decreased 44.66 13.47 3 677605 7548 89943291
Demyelination 44.38 13.47 148 677460 7992 89942847
Nocturia 44.32 13.47 11 677597 10244 89940595
Drug dose omission by device 44.17 13.47 11 677597 10220 89940619
Atrial septal defect 44.01 13.47 5 677603 8229 89942610
Mycotic allergy 44.01 13.47 47 677561 1029 89949810
Injection site reaction 43.77 13.47 948 676660 91132 89859707
Atrial flutter 43.75 13.47 13 677595 10745 89940094
Disease recurrence 43.74 13.47 140 677468 37513 89913326
Feeling hot 43.54 13.47 373 677235 77635 89873204
Needle issue 43.51 13.47 25 677583 13909 89936930
Injection site bruising 43.40 13.47 222 677386 52085 89898754
Ageusia 43.27 13.47 34 677574 16042 89934797
Hypoaesthesia oral 43.26 13.47 32 677576 15568 89935271
Respiratory acidosis 43.22 13.47 5 677603 8114 89942725
Flank pain 43.09 13.47 48 677560 19174 89931665
Spinal fracture 43.06 13.47 61 677547 21955 89928884
Off label use 42.96 13.47 7419 670189 1094833 88856006
Cold sweat 42.92 13.47 26 677582 14055 89936784
Synovial cyst 42.87 13.47 188 677420 11564 89939275
Menstruation irregular 42.82 13.47 5 677603 8055 89942784
Blood alkaline phosphatase increased 42.82 13.47 199 677409 47880 89902959
Foetal growth restriction 42.66 13.47 9 677599 9371 89941468
Haemolytic anaemia 42.62 13.47 17 677591 11680 89939159
Vitamin D deficiency 42.56 13.47 41 677567 17515 89933324
Neck pain 42.55 13.47 1135 676473 112828 89838011
Bronchopulmonary aspergillosis 42.46 13.47 16 677592 11382 89939457
Toxic encephalopathy 42.44 13.47 7 677601 8692 89942147
Red blood cell count decreased 42.38 13.47 190 677418 46161 89904678
Acute coronary syndrome 42.30 13.47 14 677594 10799 89940040
Haematocrit decreased 42.26 13.47 165 677443 41667 89909172
Wrist deformity 42.25 13.47 82 677526 3156 89947683
Facial pain 42.09 13.47 23 677585 13159 89937680
Dialysis 42.04 13.47 16 677592 11313 89939526
Multiple fractures 42.02 13.47 162 677446 9400 89941439
Skin burning sensation 41.77 13.47 51 677557 19560 89931279
Seasonal allergy 41.74 13.47 67 677541 22916 89927923
Hepatitis cholestatic 41.52 13.47 7 677601 8554 89942285
Fungal infection 41.38 13.47 171 677437 42490 89908349
Breast cancer stage II 41.27 13.47 425 677183 34909 89915930
Aspiration 41.22 13.47 34 677574 15659 89935180
Enteritis 41.02 13.47 13 677595 10308 89940531
Multiple drug therapy 40.83 13.47 3 677605 7006 89943833
Device leakage 40.76 13.47 12 677596 9979 89940860
Concussion 40.60 13.47 16 677592 11075 89939764
Haemodialysis 40.59 13.47 8 677600 8739 89942100
Bipolar disorder 40.09 13.47 9 677599 8976 89941863
Partial seizures 39.85 13.47 4 677604 7256 89943583
Intracranial pressure increased 39.43 13.47 3 677605 6808 89944031
Staphylococcal infection 39.39 13.47 207 677401 48232 89902607
Pre-existing condition improved 39.31 13.47 10 677598 9159 89941680
Skin toxicity 39.21 13.47 3 677605 6776 89944063
Peripheral coldness 39.17 13.47 28 677580 13864 89936975
Blood potassium increased 39.10 13.47 59 677549 20690 89930149
Apnoea 38.97 13.47 11 677597 9403 89941436
Salivary hypersecretion 38.82 13.47 10 677598 9082 89941757
Blood albumin decreased 38.73 13.47 41 677567 16762 89934077
Dizziness postural 38.57 13.47 10 677598 9043 89941796
Heart rate irregular 38.45 13.47 77 677531 24191 89926648
Concomitant disease aggravated 38.41 13.47 19 677589 11499 89939340
Eyelid ptosis 38.27 13.47 10 677598 8996 89941843
Brain injury 38.26 13.47 6 677602 7732 89943107
Wrist surgery 38.16 13.47 41 677567 904 89949935
Anosmia 38.09 13.47 13 677595 9835 89941004
Cardiac failure acute 37.82 13.47 21 677587 11908 89938931
Personality change 37.77 13.47 5 677603 7316 89943523
Intermenstrual bleeding 37.77 13.47 11 677597 9212 89941627
Product prescribing issue 37.66 13.47 7 677601 7972 89942867
Pneumothorax 37.59 13.47 53 677555 19114 89931725
Depression 37.55 13.47 1850 675758 298751 89652088
Lipase increased 37.55 13.47 18 677590 11093 89939746
Dry throat 37.54 13.47 7 677601 7953 89942886
Product use in unapproved indication 37.53 13.47 2093 675515 334143 89616696
Appendicitis 37.06 13.47 15 677593 10216 89940623
Bronchospasm 37.02 13.47 61 677547 20648 89930191
Vitreous floaters 37.00 13.47 6 677602 7543 89943296
Extremity contracture 36.99 13.47 47 677561 1246 89949593
Cerebral ischaemia 36.93 13.47 5 677603 7191 89943648
Granulocytopenia 36.83 13.47 3 677605 6438 89944401
Drug-induced liver injury 36.79 13.47 910 676698 89408 89861431
Breast cancer stage I 36.72 13.47 13 677595 9611 89941228
Bradykinesia 36.59 13.47 4 677604 6784 89944055
Sputum discoloured 36.51 13.47 60 677548 20331 89930508
Scratch 36.50 13.47 14 677594 9852 89940987
Metabolic encephalopathy 36.34 13.47 4 677604 6748 89944091
Blood pressure systolic decreased 36.27 13.47 12 677596 9258 89941581
Hyperthermia 36.08 13.47 16 677592 10319 89940520
Pustular psoriasis 35.97 13.47 250 677358 18306 89932533
Sensitivity to weather change 35.93 13.47 147 677461 8767 89942072
Heart rate decreased 35.92 13.47 243 677365 53262 89897577
Major depression 35.89 13.47 15 677593 10020 89940819
Anger 35.70 13.47 30 677578 13690 89937149
Lupus-like syndrome 35.65 13.47 538 677070 48308 89902531
Enterococcal infection 35.62 13.47 15 677593 9976 89940863
Upper limb fracture 35.46 13.47 67 677541 21511 89929328
Somnambulism 35.34 13.47 3 677605 6225 89944614
Rebound effect 35.25 13.47 13 677595 9371 89941468
Gingival pain 35.21 13.47 14 677594 9638 89941201
Spinal compression fracture 35.02 13.47 37 677571 15141 89935698
Hypertriglyceridaemia 35.00 13.47 8 677600 7881 89942958
Myocardial ischaemia 34.98 13.47 31 677577 13783 89937056
Bundle branch block left 34.98 13.47 8 677600 7877 89942962
Joint space narrowing 34.82 13.47 35 677573 712 89950127
Menstrual disorder 34.71 13.47 3 677605 6135 89944704
Metastasis 34.70 13.47 3 677605 6134 89944705
Psychomotor hyperactivity 34.61 13.47 27 677581 12786 89938053
Fistula 34.57 13.47 24 677584 12065 89938774
Cytopenia 34.47 13.47 48 677560 17401 89933438
Cytomegalovirus infection reactivation 34.43 13.47 8 677600 7792 89943047
Hair follicle tumour benign 34.35 13.47 27 677581 391 89950448
Prothrombin time prolonged 34.32 13.47 15 677593 9757 89941082
Neck deformity 34.31 13.47 60 677548 2129 89948710
Embolism 34.18 13.47 14 677594 9467 89941372
Pain in extremity 34.14 13.47 3858 673750 446671 89504168
Asphyxia 34.03 13.47 6 677602 7097 89943742
Infusion site pruritus 34.01 13.47 5 677603 6760 89944079
Anti-cyclic citrullinated peptide antibody 34 13.47 332 677276 26889 89923950
Anticipatory anxiety 33.99 13.47 44 677564 1189 89949650
Limb injury 33.97 13.47 121 677487 31387 89919452
Wrist fracture 33.95 13.47 40 677568 15584 89935255
Respiratory syncytial virus infection 33.88 13.47 18 677590 10462 89940377
Skin fissures 33.86 13.47 65 677543 20744 89930095
Hyperventilation 33.76 13.47 5 677603 6723 89944116
Gastroenteritis 33.73 13.47 109 677499 29120 89921719
Pelvic pain 33.71 13.47 39 677569 15318 89935521
Glucose tolerance impaired 33.68 13.47 9 677599 7976 89942863
Exposure during pregnancy 33.57 13.47 2139 675469 236271 89714568
Breast pain 33.53 13.47 18 677590 10400 89940439
Abnormal faeces 33.45 13.47 5 677603 6677 89944162
Pseudomonas infection 33.45 13.47 37 677571 14828 89936011
Arteriosclerosis coronary artery 33.31 13.47 15 677593 9588 89941251
Drug effective for unapproved indication 33.25 13.47 9 677599 7909 89942930
Bradyphrenia 33.22 13.47 8 677600 7604 89943235
Transaminases abnormal 33.15 13.47 34 677574 709 89950130
Surgery 33.14 13.47 198 677410 44689 89906150
Transplant rejection 33.07 13.47 28 677580 12730 89938109
Maternal exposure timing unspecified 33.04 13.47 284 677324 22199 89928640
Aspergillus infection 32.97 13.47 20 677588 10803 89940036
Nystagmus 32.73 13.47 7 677601 7220 89943619
Maternal exposure during breast feeding 32.69 13.47 4 677604 6216 89944623
Mycobacterium tuberculosis complex test positive 32.69 13.47 65 677543 2547 89948292
Thinking abnormal 32.62 13.47 24 677584 11708 89939131
Joint arthroplasty 32.61 13.47 77 677531 3400 89947439
Oligohydramnios 32.56 13.47 7 677601 7194 89943645
Localised oedema 32.52 13.47 4 677604 6190 89944649
Systemic inflammatory response syndrome 32.34 13.47 5 677603 6511 89944328
Bowel movement irregularity 32.32 13.47 5 677603 6509 89944330
Post procedural complication 32.29 13.47 58 677550 18984 89931855
Middle insomnia 32.18 13.47 47 677561 16704 89934135
Skin papilloma 32.16 13.47 104 677504 5526 89945313
Intentional dose omission 32.15 13.47 52 677556 17731 89933108
Cholecystitis acute 32.14 13.47 15 677593 9389 89941450
Pulmonary haemorrhage 32.01 13.47 10 677598 8003 89942836
Ovarian neoplasm 31.97 13.47 37 677571 888 89949951
SARS-CoV-2 test positive 31.94 13.47 22 677586 11106 89939733
Blood thyroid stimulating hormone decreased 31.94 13.47 3 677605 5737 89945102
Product availability issue 31.89 13.47 8 677600 7396 89943443
Porphyria acute 31.85 13.47 237 677371 17738 89933101
Bone density abnormal 31.82 13.47 85 677523 4055 89946784
Epstein-Barr virus infection 31.67 13.47 19 677589 10325 89940514
Abscess 31.63 13.47 58 677550 18833 89932006
Splenomegaly 31.54 13.47 30 677578 12894 89937945
Dermatitis bullous 31.51 13.47 19 677589 10297 89940542
Eating disorder 31.49 13.47 106 677502 27967 89922872
Klebsiella infection 31.41 13.47 19 677589 10278 89940561
Thyroid neoplasm 31.35 13.47 83 677525 3938 89946901
Bladder disorder 31.31 13.47 21 677587 10751 89940088
Paralysis 31.24 13.47 24 677584 11454 89939385
Brain natriuretic peptide increased 31.23 13.47 4 677604 6001 89944838
Micturition urgency 31.20 13.47 23 677585 11210 89939629
Bronchitis chronic 31.17 13.47 92 677516 4651 89946188
Infiltration anaesthesia 31.06 13.47 19 677589 178 89950661
Gastrointestinal procedural complication 30.98 13.47 27 677581 455 89950384
Soft tissue disorder 30.90 13.47 86 677522 4204 89946635
Ear discomfort 30.86 13.47 19 677589 10181 89940658
Activated partial thromboplastin time prolonged 30.84 13.47 10 677598 7815 89943024
Expired product administered 30.75 13.47 7 677601 6915 89943924
Blood thyroid stimulating hormone increased 30.68 13.47 15 677593 9140 89941699
Respiratory rate increased 30.64 13.47 45 677563 15956 89934883
Gastric disorder 30.60 13.47 383 677225 33001 89917838
Metabolic disorder 30.42 13.47 9 677599 7461 89943378
Erythema multiforme 30.39 13.47 28 677580 12218 89938621
Lung infiltration 30.23 13.47 42 677566 15240 89935599
Pyelonephritis 30.17 13.47 72 677536 21244 89929595
Drug level below therapeutic 29.93 13.47 4 677604 5810 89945029
Hypovolaemic shock 29.91 13.47 8 677600 7086 89943753
Tumour marker increased 29.88 13.47 4 677604 5803 89945036
Rales 29.83 13.47 45 677563 15782 89935057
Mean cell haemoglobin decreased 29.69 13.47 102 677506 5593 89945246
Diastolic dysfunction 29.57 13.47 9 677599 7324 89943515
Pharyngitis 29.56 13.47 272 677336 21675 89929164
Refusal of treatment by patient 29.41 13.47 4 677604 5734 89945105
Breast cancer female 29.36 13.47 41 677567 14845 89935994
Frequent bowel movements 29.25 13.47 278 677330 56657 89894182
Dyspepsia 29.21 13.47 1785 675823 196375 89754464
Hepatomegaly 29.08 13.47 34 677574 13292 89937547
Fine motor skill dysfunction 29.08 13.47 98 677510 5321 89945518
Tension headache 28.89 13.47 10 677598 7499 89943340
Product complaint 28.87 13.47 35 677573 13465 89937374
Polycystic ovaries 28.84 13.47 4 677604 5650 89945189
Aortic valve incompetence 28.83 13.47 7 677601 6617 89944222
Heart rate abnormal 28.70 13.47 5 677603 5966 89944873
Supraventricular extrasystoles 28.59 13.47 3 677605 5254 89945585
Paronychia 28.58 13.47 12 677596 7994 89942845
Stillbirth 28.49 13.47 10 677598 7433 89943406
Petechiae 28.48 13.47 46 677562 15695 89935144
Aphonia 28.46 13.47 30 677578 12289 89938550
Ketoacidosis 28.44 13.47 4 677604 5591 89945248
Product dose omission in error 28.43 13.47 70 677538 20433 89930406
Angina unstable 28.38 13.47 9 677599 7134 89943705
Urticarial vasculitis 28.35 13.47 37 677571 1008 89949831
Respiration abnormal 28.32 13.47 12 677596 7951 89942888
Blood glucose abnormal 28.28 13.47 18 677590 9474 89941365
Dactylitis 28.25 13.47 78 677530 3795 89947044
Gout 28.01 13.47 52 677556 16807 89934032
Peritonitis bacterial 28.00 13.47 3 677605 5168 89945671
Hypermobility syndrome 27.99 13.47 34 677574 860 89949979
Allergic oedema 27.92 13.47 35 677573 915 89949924
Arteriosclerosis 27.91 13.47 24 677584 10829 89940010
Pancreatitis 27.91 13.47 361 677247 69465 89881374
Mixed liver injury 27.90 13.47 11 677597 7612 89943227
Hypertonia 27.88 13.47 3 677605 5152 89945687
Drug level above therapeutic 27.63 13.47 5 677603 5804 89945035
Forced expiratory volume decreased 27.62 13.47 5 677603 5803 89945036
Abdominal distension 27.56 13.47 754 676854 129847 89820992
Drug dependence 27.55 13.47 119 677489 29208 89921631
Hepatic cirrhosis 27.48 13.47 643 676965 62610 89888229
Hypophagia 27.34 13.47 157 677451 35780 89915059
Injection site pruritus 27.18 13.47 264 677344 53570 89897269
Arteriospasm coronary 27.16 13.47 3 677605 5047 89945792
Seronegative arthritis 27.15 13.47 231 677377 18003 89932836
Nail operation 27.01 13.47 50 677558 1856 89948983
Photopsia 26.98 13.47 3 677605 5021 89945818
Labile blood pressure 26.94 13.47 50 677558 1860 89948979
Photophobia 26.92 13.47 76 677532 21193 89929646
Mass excision 26.75 13.47 22 677586 341 89950498
Secretion discharge 26.71 13.47 207 677401 15689 89935150
Aortic arteriosclerosis 26.66 13.47 12 677596 7672 89943167
Osteoporotic fracture 26.62 13.47 87 677521 4649 89946190
Vasculitic rash 26.60 13.47 42 677566 1368 89949471
Blood pressure abnormal 26.52 13.47 68 677540 19577 89931262
Orthopnoea 26.48 13.47 9 677599 6826 89944013
Cardiac tamponade 26.46 13.47 5 677603 5627 89945212
Polyp 26.42 13.47 12 677596 7632 89943207
Diffuse large B-cell lymphoma 26.30 13.47 16 677592 8629 89942210
Congestive cardiomyopathy 26.29 13.47 11 677597 7343 89943496
Internal haemorrhage 26.25 13.47 7 677601 6213 89944626
Taste disorder 26.23 13.47 624 676984 60922 89889917
Joint dislocation 26.23 13.47 474 677134 44108 89906731
Spinal cord compression 26.21 13.47 3 677605 4908 89945931
Cardiac murmur 26.11 13.47 61 677547 18133 89932706
Eye movement disorder 26.11 13.47 7 677601 6191 89944648
Autoimmune thyroiditis 26.10 13.47 6 677602 5887 89944952
Product dispensing error 26.05 13.47 32 677576 12241 89938598
Dental caries 26.05 13.47 28 677580 11369 89939470
Nervous system disorder 25.99 13.47 79 677529 21514 89929325
Pneumonia fungal 25.98 13.47 10 677598 7021 89943818
Invasive ductal breast carcinoma 25.91 13.47 13 677595 7805 89943034
Sudden death 25.84 13.47 26 677582 10883 89939956
Device occlusion 25.79 13.47 19 677589 9263 89941576
Loss of employment 25.71 13.47 64 677544 2923 89947916
Breast cancer recurrent 25.61 13.47 5 677603 5498 89945341
Large intestine perforation 25.56 13.47 21 677587 9691 89941148
Lyme disease 25.51 13.47 80 677528 4182 89946657
Bladder cancer 25.51 13.47 6 677602 5795 89945044
Ulcer haemorrhage 25.44 13.47 305 677303 26016 89924823
Oral mucosal blistering 25.33 13.47 10 677598 6914 89943925
Conjunctivitis 25.31 13.47 108 677500 26598 89924241
Snoring 25.29 13.47 4 677604 5122 89945717
Paradoxical drug reaction 25.28 13.47 6 677602 5760 89945079
Cholangitis 25.26 13.47 11 677597 7171 89943668
Renal cyst 25.21 13.47 36 677572 12914 89937925
Hyperpyrexia 25.18 13.47 3 677605 4758 89946081
Gastrointestinal infection 25.12 13.47 27 677581 10963 89939876
Neoplasm 25.03 13.47 18 677590 8885 89941954
Ventricular septal defect 24.98 13.47 5 677603 5402 89945437
International normalised ratio decreased 24.92 13.47 3 677605 4721 89946118
Stress 24.92 13.47 443 677165 80952 89869887
Pneumonia viral 24.84 13.47 131 677477 8692 89942147
Injection site rash 24.64 13.47 95 677513 24078 89926761
Extrasystoles 24.58 13.47 6 677602 5651 89945188
Injection site urticaria 24.58 13.47 62 677546 17949 89932890
Meningitis aseptic 24.42 13.47 10 677598 6763 89944076
Haemorrhagic stroke 24.40 13.47 9 677599 6487 89944352
Pelvic fracture 24.36 13.47 48 677560 15171 89935668
Hyperammonaemia 24.27 13.47 9 677599 6466 89944373
Pharyngitis streptococcal 24.24 13.47 36 677572 12706 89938133
Enthesophyte 24.13 13.47 15 677593 145 89950694
Oxygen consumption increased 24.00 13.47 3 677605 4586 89946253
Urine abnormality 23.99 13.47 14 677594 7723 89943116
Premature rupture of membranes 23.95 13.47 6 677602 5552 89945287
Anxiety disorder 23.93 13.47 4 677604 4918 89945921
Choking 23.87 13.47 33 677575 12000 89938839
Incorrect drug administration rate 23.78 13.47 5 677603 5218 89945621
Urine analysis abnormal 23.76 13.47 5 677603 5216 89945623
Fear of injection 23.68 13.47 126 677482 8389 89942450
Intestinal ischaemia 23.64 13.47 19 677589 8864 89941975
Hordeolum 23.63 13.47 4 677604 4874 89945965
Hydronephrosis 23.63 13.47 35 677573 12367 89938472
Hepatitis acute 23.52 13.47 28 677580 10859 89939980
Tooth extraction 23.42 13.47 31 677577 11482 89939357
Femur fracture 23.38 13.47 479 677129 45603 89905236
Retinal haemorrhage 23.37 13.47 7 677601 5757 89945082
Tongue oedema 23.28 13.47 6 677602 5448 89945391
Sleep terror 23.15 13.47 3 677605 4461 89946378
Sexual dysfunction 23.14 13.47 4 677604 4800 89946039
Stridor 23.07 13.47 4 677604 4789 89946050
Infusion site haemorrhage 23.01 13.47 6 677602 5405 89945434
COVID-19 pneumonia 22.97 13.47 65 677543 18112 89932727
Haemolysis 22.90 13.47 18 677590 8492 89942347
Blood test abnormal 22.90 13.47 80 677528 20872 89929967
Ileus paralytic 22.88 13.47 5 677603 5080 89945759
Disease susceptibility 22.82 13.47 18 677590 262 89950577
Sluggishness 22.82 13.47 8 677600 5951 89944888
Blood culture positive 22.79 13.47 5 677603 5067 89945772
Catheter site infection 22.69 13.47 7 677601 5647 89945192
Overweight 22.66 13.47 8 677600 5926 89944913
Large intestine polyp 22.66 13.47 22 677586 9364 89941475
Mood swings 22.65 13.47 79 677529 20623 89930216
Mean cell haemoglobin concentration abnormal 22.64 13.47 14 677594 134 89950705
Polyuria 22.58 13.47 25 677583 10015 89940824
Infusion site bruising 22.52 13.47 3 677605 4369 89946470
Bruxism 22.46 13.47 3 677605 4360 89946479
Ear infection 22.46 13.47 682 676926 69093 89881746
Left ventricular failure 22.42 13.47 11 677597 6689 89944150
Blood urine present 22.42 13.47 61 677547 17217 89933622
Humerus fracture 22.41 13.47 24 677584 9761 89941078
Gingival swelling 22.41 13.47 5 677603 5008 89945831
Facial paralysis 22.36 13.47 52 677556 15482 89935357
Renal function test abnormal 22.31 13.47 13 677595 7178 89943661
Intestinal sepsis 22.25 13.47 19 677589 311 89950528
Dry eye 22.24 13.47 302 677306 57629 89893210
Blood phosphorus increased 22.16 13.47 3 677605 4315 89946524
Skin abrasion 22.10 13.47 31 677577 11204 89939635
Catheterisation cardiac 22.04 13.47 5 677603 4951 89945888
Dysaesthesia 22.02 13.47 6 677602 5249 89945590
Product residue present 21.97 13.47 3 677605 4288 89946551
Arthritis bacterial 21.97 13.47 112 677496 7333 89943506
Hydrocephalus 21.97 13.47 9 677599 6085 89944754
Peripheral sensory neuropathy 21.96 13.47 22 677586 9228 89941611
Muscle strain 21.92 13.47 24 677584 9663 89941176
Fracture delayed union 21.90 13.47 54 677554 2452 89948387
Escherichia urinary tract infection 21.75 13.47 44 677564 13771 89937068
Pneumonia bacterial 21.65 13.47 39 677569 12751 89938088
Retinal detachment 21.64 13.47 12 677596 6810 89944029
Functional gastrointestinal disorder 21.62 13.47 85 677523 4977 89945862
Blood pressure diastolic decreased 21.61 13.47 115 677493 26711 89924128
Polydipsia 21.57 13.47 3 677605 4228 89946611
Bedridden 21.43 13.47 160 677448 11988 89938851
Brain herniation 21.36 13.47 3 677605 4197 89946642
Uterine leiomyoma 21.35 13.47 30 677578 10834 89940005
Middle lobe syndrome 21.31 13.47 9 677599 34 89950805
Pyelonephritis acute 21.31 13.47 7 677601 5425 89945414
Defaecation urgency 21.27 13.47 10 677598 6232 89944607
Ankle deformity 21.25 13.47 22 677586 464 89950375
Clostridium test positive 21.12 13.47 7 677601 5394 89945445
Hyperuricaemia 21.06 13.47 12 677596 6707 89944132
Formication 20.98 13.47 5 677603 4786 89946053
Pancreatic carcinoma 20.97 13.47 19 677589 8358 89942481
Hepatic necrosis 20.90 13.47 11 677597 6427 89944412
Visual field defect 20.79 13.47 14 677594 7152 89943687
Feeling drunk 20.76 13.47 5 677603 4753 89946086
Colon cancer 20.74 13.47 31 677577 10913 89939926
Sleep disorder due to a general medical condition 20.69 13.47 224 677384 44514 89906325
Drug effect less than expected 20.66 13.47 10 677598 6128 89944711
Ocular discomfort 20.51 13.47 11 677597 6359 89944480
Small for dates baby 20.45 13.47 6 677602 5001 89945838
Graft versus host disease in gastrointestinal tract 20.39 13.47 4 677604 4384 89946455
Eye discharge 20.35 13.47 19 677589 8239 89942600
Non-small cell lung cancer 20.35 13.47 4 677604 4377 89946462
Hair texture abnormal 20.31 13.47 5 677603 4682 89946157
Coronary artery stenosis 20.28 13.47 7 677601 5259 89945580
Post-traumatic stress disorder 20.27 13.47 13 677595 6815 89944024
Bacterial test positive 20.26 13.47 8 677600 5531 89945308
Galactorrhoea 20.21 13.47 5 677603 4667 89946172
Mass 20.20 13.47 55 677553 15522 89935317
Rash morbilliform 20.20 13.47 3 677605 4026 89946813
Renal pain 20.15 13.47 17 677591 7742 89943097
Diabetic eye disease 20.14 13.47 14 677594 166 89950673
Hidradenitis 20.12 13.47 4 677604 4343 89946496
Gallbladder disorder 20.07 13.47 78 677530 19725 89931114
Hypertensive crisis 20.05 13.47 67 677541 17717 89933122
Lip oedema 20.00 13.47 5 677603 4634 89946205
Immune reconstitution inflammatory syndrome 19.98 13.47 14 677594 7005 89943834
Haemarthrosis 19.97 13.47 3 677605 3991 89946848
Vulvovaginal pruritus 19.96 13.47 3 677605 3990 89946849
Hepatic enzyme abnormal 19.85 13.47 111 677497 7531 89943308
Blepharitis 19.85 13.47 3 677605 3973 89946866
Aplasia pure red cell 19.84 13.47 7 677601 5187 89945652
Pulmonary alveolar haemorrhage 19.84 13.47 10 677598 5988 89944851
Spinal meningioma benign 19.83 13.47 12 677596 110 89950729
Odynophagia 19.81 13.47 23 677585 9020 89941819
Gastroenteritis viral 19.81 13.47 139 677469 30216 89920623
Optic neuritis 19.75 13.47 26 677582 9652 89941187
Colitis ulcerative 19.74 13.47 324 677284 59942 89890897
Cerebral haematoma 19.74 13.47 4 677604 4285 89946554
Bunion operation 19.72 13.47 36 677572 1322 89949517
Cataract 19.72 13.47 400 677208 71692 89879147
Blood creatine increased 19.70 13.47 14 677594 6953 89943886
Cardiac operation 19.67 13.47 3 677605 3946 89946893
Leukoencephalopathy 19.61 13.47 6 677602 4867 89945972
Maternal drugs affecting foetus 19.60 13.47 7 677601 5148 89945691
Anaphylactic shock 19.57 13.47 147 677461 31470 89919369
Sinus node dysfunction 19.50 13.47 8 677600 5404 89945435
Immobile 19.41 13.47 97 677511 6301 89944538
Pulmonary congestion 19.41 13.47 77 677531 19356 89931483
Eye injury 19.35 13.47 145 677463 10875 89939964
Thrombophlebitis 19.33 13.47 6 677602 4822 89946017
Cardiac failure chronic 19.31 13.47 9 677599 5637 89945202
Laryngeal oedema 19.23 13.47 14 677594 6867 89943972
Decubitus ulcer 19.13 13.47 37 677571 11776 89939063
Sensation of foreign body 19.06 13.47 12 677596 6354 89944485
Skin tightness 19.04 13.47 5 677603 4483 89946356
Incorrect product administration duration 19.02 13.47 77 677531 19245 89931594
Dermatitis acneiform 19.00 13.47 12 677596 6342 89944497
Amylase increased 18.98 13.47 15 677593 7057 89943782
Lung opacity 18.98 13.47 11 677597 6091 89944748
Carotid artery occlusion 18.93 13.47 12 677596 6330 89944509
Insomnia 18.91 13.47 2806 674802 330668 89620171
Aortic stenosis 18.90 13.47 12 677596 6324 89944515
Type I hypersensitivity 18.87 13.47 4 677604 4151 89946688
Faeces soft 18.85 13.47 17 677591 7494 89943345
Culture urine positive 18.84 13.47 3 677605 3822 89947017
Swollen joint count 18.83 13.47 120 677488 8533 89942306
Juvenile idiopathic arthritis 18.82 13.47 69 677539 3908 89946931
Mouth ulceration 18.82 13.47 411 677197 39563 89911276
Paraesthesia 18.80 13.47 1613 675995 248713 89702126
Cardiovascular disorder 18.76 13.47 46 677562 13446 89937393
Depressive symptom 18.74 13.47 8 677600 5277 89945562
Vitamin B12 deficiency 18.72 13.47 17 677591 7469 89943370
Trigeminal neuralgia 18.71 13.47 4 677604 4127 89946712
Neutrophil count abnormal 18.69 13.47 4 677604 4124 89946715
Dermatitis exfoliative 18.66 13.47 9 677599 5527 89945312
Rheumatic disorder 18.61 13.47 62 677546 3346 89947493
Leukaemia 18.61 13.47 7 677601 4985 89945854
Malaise 18.60 13.47 3985 673623 582001 89368838
Ammonia increased 18.57 13.47 7 677601 4979 89945860
Compression fracture 18.57 13.47 23 677585 8766 89942073
Hepatic fibrosis 18.56 13.47 71 677537 4104 89946735
Rheumatoid factor 18.51 13.47 21 677587 493 89950346
Allergy to chemicals 18.50 13.47 66 677542 3688 89947151
Alanine aminotransferase abnormal 18.44 13.47 85 677523 5341 89945498
Bacterial sepsis 18.38 13.47 7 677601 4948 89945891
Drug screen positive 18.38 13.47 3 677605 3754 89947085
Gamma-glutamyltransferase increased 18.37 13.47 188 677420 37764 89913075
Incorrect dose administered by device 18.33 13.47 10 677598 5727 89945112
Hypocholesterolaemia 18.33 13.47 96 677512 6353 89944486
Facial bones fracture 18.31 13.47 3 677605 3744 89947095
Thoracic vertebral fracture 18.30 13.47 9 677599 5465 89945374
Pregnancy 18.27 13.47 600 677008 61447 89889392
Fibrin D dimer increased 18.22 13.47 9 677599 5451 89945388
Bone disorder 18.19 13.47 258 677350 22862 89927977
Pneumonitis 18.16 13.47 227 677381 43943 89906896
Hypertonic bladder 18.15 13.47 5 677603 4343 89946496
Hyperphosphataemia 18.07 13.47 3 677605 3708 89947131
Impaired driving ability 18.07 13.47 8 677600 5165 89945674
Device failure 18.05 13.47 15 677593 6882 89943957
Psychiatric symptom 17.99 13.47 16 677592 7102 89943737
Ventricular arrhythmia 17.98 13.47 5 677603 4316 89946523
Hepatic cancer 17.94 13.47 7 677601 4874 89945965
Mouth swelling 17.90 13.47 10 677598 5652 89945187
Ligament sprain 17.87 13.47 53 677555 14546 89936293
Pseudomonal sepsis 17.86 13.47 5 677603 4297 89946542
Anal fistula 17.85 13.47 5 677603 4296 89946543
White blood cell count increased 17.82 13.47 375 677233 66866 89883973
Blood lactate dehydrogenase increased 17.80 13.47 117 677491 25815 89925024
Neurological symptom 17.78 13.47 15 677593 6832 89944007
Faecal calprotectin increased 17.78 13.47 4 677604 3983 89946856
Overwork 17.76 13.47 9 677599 56 89950783
Performance status decreased 17.72 13.47 5 677603 4275 89946564
Osteonecrosis 17.70 13.47 119 677489 26122 89924717
Oesophageal candidiasis 17.69 13.47 15 677593 6814 89944025
Oropharyngeal discomfort 17.69 13.47 19 677589 7716 89943123
Subileus 17.63 13.47 3 677605 3641 89947198
Product monitoring error 17.57 13.47 6 677602 4538 89946301
Dermatitis exfoliative generalised 17.51 13.47 10 677598 5583 89945256
Femoral neck fracture 17.51 13.47 31 677577 10202 89940637
Tooth fracture 17.48 13.47 43 677565 12557 89938282
Abdominal hernia 17.43 13.47 11 677597 5817 89945022
Laryngitis 17.40 13.47 500 677108 50253 89900586
Impaired gastric emptying 17.38 13.47 159 677449 12650 89938189
Pulmonary function test decreased 17.26 13.47 6 677602 4488 89946351
Nasal discomfort 17.26 13.47 10 677598 5538 89945301
Diverticulum intestinal 17.22 13.47 26 677582 9116 89941723
Vulvovaginal candidiasis 17.21 13.47 4 677604 3896 89946943
Jugular vein thrombosis 17.21 13.47 3 677605 3578 89947261
Venous thrombosis 17.19 13.47 10 677598 5527 89945312
Mean cell volume increased 17.17 13.47 8 677600 5013 89945826
Autoimmune hepatitis 17.13 13.47 32 677576 10319 89940520
Hepatic ischaemia 17.10 13.47 25 677583 760 89950079
Pseudomembranous colitis 17.01 13.47 4 677604 3864 89946975
Incoherent 16.92 13.47 8 677600 4969 89945870
Soft tissue swelling 16.90 13.47 34 677574 1344 89949495
Hypopnoea 16.88 13.47 6 677602 4425 89946414
Hyperlactacidaemia 16.81 13.47 5 677603 4131 89946708
Oesophageal stenosis 16.80 13.47 4 677604 3832 89947007
Candida infection 16.78 13.47 168 677440 33889 89916950
Immunosuppressant drug level increased 16.73 13.47 7 677601 4673 89946166
Haemoglobin abnormal 16.73 13.47 17 677591 7083 89943756
Bundle branch block right 16.72 13.47 10 677598 5443 89945396
Walking aid user 16.69 13.47 365 677243 35141 89915698
Protein total decreased 16.67 13.47 17 677591 7072 89943767
Blindness unilateral 16.60 13.47 20 677588 7716 89943123
Urosepsis 16.56 13.47 92 677516 21140 89929699
Asthma-chronic obstructive pulmonary disease overlap syndrome 16.46 13.47 8 677600 4891 89945948
Tachyarrhythmia 16.45 13.47 10 677598 5396 89945443
Coronary artery occlusion 16.43 13.47 24 677584 8530 89942309
Steatohepatitis 16.36 13.47 25 677583 791 89950048
Diverticulum 16.30 13.47 42 677566 12071 89938768
Squamous cell carcinoma of skin 16.26 13.47 19 677589 7430 89943409
Pneumatosis intestinalis 16.26 13.47 3 677605 3434 89947405
Brain neoplasm 16.25 13.47 8 677600 4856 89945983
Pharyngeal swelling 16.23 13.47 31 677577 9913 89940926
Kidney transplant rejection 16.21 13.47 8 677600 4849 89945990
Iron deficiency anaemia 16.12 13.47 107 677501 23555 89927284
Gastritis erosive 16.12 13.47 16 677592 6739 89944100
Rhinitis 16.09 13.47 50 677558 13522 89937317
Nasal dryness 16.07 13.47 11 677597 5572 89945267
Methaemoglobinaemia 16.06 13.47 5 677603 4010 89946829
Muscle relaxant therapy 16.02 13.47 12 677596 161 89950678
Poor quality product administered 16.01 13.47 5 677603 4003 89946836
Device use issue 16.01 13.47 4 677604 3709 89947130
Product distribution issue 15.96 13.47 4 677604 3701 89947138
White blood cells urine positive 15.96 13.47 15 677593 6483 89944356
Jaw disorder 15.94 13.47 11 677597 5548 89945291
Vaginal infection 15.90 13.47 24 677584 8416 89942423
Lacunar infarction 15.86 13.47 3 677605 3374 89947465
Subcutaneous drug absorption impaired 15.85 13.47 163 677445 13382 89937457
Neutrophilia 15.83 13.47 12 677596 5766 89945073
Decreased activity 15.72 13.47 23 677585 8169 89942670
Injection site extravasation 15.72 13.47 27 677581 8992 89941847
Blood pressure inadequately controlled 15.72 13.47 14 677594 6210 89944629
Muscle haemorrhage 15.66 13.47 3 677605 3343 89947496
Gastrooesophageal reflux disease 15.62 13.47 1052 676556 165285 89785554
Choking sensation 15.60 13.47 5 677603 3937 89946902
Blood iron decreased 15.60 13.47 75 677533 17884 89932955
Escherichia bacteraemia 15.60 13.47 12 677596 5723 89945116
Atypical femur fracture 15.56 13.47 15 677593 6406 89944433
Synovial disorder 15.52 13.47 55 677553 3063 89947776
Injection site nodule 15.50 13.47 7 677601 4466 89946373
Stent placement 15.49 13.47 6 677602 4197 89946642
Attention deficit hyperactivity disorder 15.38 13.47 6 677602 4178 89946661
Systemic candida 15.34 13.47 9 677599 4950 89945889
Staphylococcal bacteraemia 15.31 13.47 20 677588 7449 89943390
Aneurysm 15.29 13.47 4 677604 3596 89947243
Endophthalmitis 15.22 13.47 8 677600 4677 89946162
Temperature intolerance 15.21 13.47 43 677565 11987 89938852
Fluid intake reduced 15.18 13.47 6 677602 4146 89946693
Intestinal perforation 15.17 13.47 53 677555 13828 89937011
Feeling of body temperature change 15.14 13.47 12 677596 5637 89945202
Atypical pneumonia 15.10 13.47 10 677598 5154 89945685
Crying 15.04 13.47 121 677487 25524 89925315
Throat clearing 15.02 13.47 5 677603 3842 89946997
Abdominal adhesions 15.01 13.47 4 677604 3551 89947288
Anal fissure 14.99 13.47 11 677597 5374 89945465
Faeces hard 14.97 13.47 3 677605 3239 89947600
Erysipelas 14.97 13.47 28 677580 9024 89941815
Breast mass 14.95 13.47 30 677578 9417 89941422
Body height decreased 14.90 13.47 43 677565 11906 89938933
Serum ferritin increased 14.89 13.47 20 677588 7361 89943478
Inadequate analgesia 14.85 13.47 3 677605 3221 89947618
Neck mass 14.85 13.47 63 677545 3819 89947020
Hypercalcaemia 14.85 13.47 348 677260 33892 89916947
Renal tubular disorder 14.74 13.47 3 677605 3204 89947635
Scleroderma 14.74 13.47 15 677593 6246 89944593
Herpes simplex 14.72 13.47 34 677574 10147 89940692
Tooth loss 14.70 13.47 21 677587 7533 89943306
Total lung capacity decreased 14.70 13.47 5 677603 3790 89947049
Increased tendency to bruise 14.67 13.47 43 677565 11847 89938992
Blood glucose fluctuation 14.65 13.47 10 677598 5073 89945766
Exfoliative rash 14.65 13.47 3 677605 3189 89947650
General symptom 14.63 13.47 171 677437 14497 89936342
Hypovolaemia 14.59 13.47 46 677562 12385 89938454
Cutaneous vasculitis 14.59 13.47 98 677510 7095 89943744
Skin reaction 14.58 13.47 207 677401 18346 89932493
Herpes zoster 14.58 13.47 569 677039 94075 89856764
Blood sodium increased 14.58 13.47 3 677605 3179 89947660
Device defective 14.57 13.47 4 677604 3482 89947357
Trismus 14.56 13.47 9 677599 4812 89946027
Visual impairment 14.55 13.47 825 676783 131540 89819299
Epilepsy 14.54 13.47 753 676855 81453 89869386
Pharyngeal paraesthesia 14.53 13.47 3 677605 3171 89947668
Metastatic neoplasm 14.52 13.47 9 677599 4806 89946033
Skin cancer 14.52 13.47 52 677556 13467 89937372
Ischaemia 14.50 13.47 11 677597 5284 89945555
Hyperaesthesia 14.48 13.47 37 677571 10665 89940174
Inhibitory drug interaction 14.46 13.47 3 677605 3160 89947679
Blindness transient 14.40 13.47 8 677600 4535 89946304
Ventricular dysfunction 14.30 13.47 5 677603 3726 89947113
Exposure to communicable disease 14.30 13.47 21 677587 641 89950198
Vitamin D decreased 14.29 13.47 44 677564 11935 89938904
Intervertebral disc space narrowing 14.28 13.47 28 677580 1086 89949753
Muscle disorder 14.23 13.47 12 677596 5467 89945372
Polyomavirus-associated nephropathy 14.23 13.47 46 677562 2444 89948395
Ocular icterus 14.15 13.47 6 677602 3974 89946865
Periorbital oedema 14.15 13.47 18 677590 6781 89944058
Hepatitis B reactivation 14.11 13.47 6 677602 3968 89946871
Thrombocytosis 14.09 13.47 19 677589 6982 89943857
Wheezing 14.05 13.47 2008 675600 236072 89714767
Incorrect route of product administration 14 13.47 486 677122 50140 89900699
Limb operation 13.99 13.47 69 677539 4458 89946381
Hair growth abnormal 13.96 13.47 5 677603 3671 89947168
Hepatitis fulminant 13.94 13.47 6 677602 3939 89946900
Spinal flattening 13.92 13.47 14 677594 285 89950554
Papule 13.91 13.47 24 677584 7978 89942861
Sensitive skin 13.91 13.47 4 677604 3377 89947462
Haematocrit increased 13.90 13.47 3 677605 3075 89947764
Injection site hypersensitivity 13.90 13.47 48 677560 2639 89948200
Portal hypertension 13.89 13.47 9 677599 4692 89946147
Malignant neoplasm of conjunctiva 13.88 13.47 7 677601 43 89950796
Pulmonary thrombosis 13.88 13.47 33 677575 9749 89941090
Clear cell renal cell carcinoma 13.76 13.47 34 677574 1546 89949293
Papulopustular rosacea 13.75 13.47 7 677601 44 89950795
Arthropod bite 13.73 13.47 28 677580 8739 89942100
Oral discomfort 13.66 13.47 129 677479 10354 89940485
Wound dehiscence 13.65 13.47 14 677594 5808 89945031
Cardiac pacemaker insertion 13.63 13.47 8 677600 4399 89946440
Bone marrow disorder 13.60 13.47 3 677605 3029 89947810
Skin hypertrophy 13.56 13.47 5 677603 3605 89947234
Skin lesion 13.56 13.47 197 677411 37168 89913671
Cardiac flutter 13.54 13.47 9 677599 4629 89946210
Thrombotic thrombocytopenic purpura 13.54 13.47 7 677601 4131 89946708
Clostridial infection 13.53 13.47 9 677599 4627 89946212
Micturition disorder 13.53 13.47 3 677605 3017 89947822

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 1989.61 14.95 3654 67680 626543 41923458
Rheumatoid arthritis 1910.23 14.95 1070 70264 41370 42508631
Joint swelling 1760.31 14.95 1205 70129 66817 42483184
Drug intolerance 1432.99 14.95 1138 70196 79286 42470715
Synovitis 928.56 14.95 474 70860 15093 42534908
Contraindicated product administered 915.28 14.95 554 70780 24718 42525283
C-reactive protein abnormal 751.03 14.95 348 70986 8913 42541088
Treatment failure 730.83 14.95 697 70637 61927 42488074
Arthralgia 672.63 14.95 1218 70116 204020 42345981
Arthropathy 663.24 14.95 481 70853 29116 42520885
Apparent death 640.16 14.95 239 71095 3469 42546532
Musculoskeletal stiffness 562.87 14.95 583 70751 57182 42492819
Bone erosion 555.36 14.95 226 71108 4177 42545824
Pain 539.80 14.95 1233 70101 243615 42306386
Therapeutic product effect decreased 534.62 14.95 476 70858 38674 42511327
Psoriatic arthropathy 501.48 14.95 380 70954 24587 42525414
Red blood cell sedimentation rate abnormal 484.16 14.95 197 71137 3639 42546362
Diverticulitis 436.23 14.95 337 70997 22436 42527565
Drug hypersensitivity 376.80 14.95 630 70704 98759 42451242
Mobility decreased 348.45 14.95 359 70975 34947 42515054
Hand deformity 325.48 14.95 148 71186 3620 42546381
C-reactive protein increased 319.33 14.95 459 70875 63101 42486900
Drug eruption 315.70 14.95 281 71053 22794 42527207
Red blood cell sedimentation rate increased 307.06 14.95 197 71137 9727 42540274
Urticaria 300.28 14.95 484 70850 73552 42476449
Pain in extremity 294.60 14.95 725 70609 149879 42400122
Arthritis 277.44 14.95 347 70987 41718 42508283
Death 273.71 14.95 233 71101 470952 42079049
Stomatitis 272.83 14.95 377 70957 49952 42500049
Febrile neutropenia 267.08 14.95 10 71324 185693 42364308
Loss of personal independence in daily activities 259.35 14.95 366 70968 49450 42500551
Hypotension 227.66 14.95 74 71260 257557 42292444
Osteoarthritis 219.06 14.95 236 71098 24169 42525832
Sleep disorder due to general medical condition, insomnia type 218.67 14.95 85 71249 1384 42548617
Disability 211.82 14.95 129 71205 5804 42544197
Hypersensitivity 211.64 14.95 410 70924 71960 42478041
Rheumatoid nodule 207.40 14.95 101 71233 2894 42547107
Alanine aminotransferase abnormal 203.94 14.95 118 71216 4826 42545175
Rheumatoid factor negative 203.33 14.95 73 71261 941 42549060
Chondropathy 200.96 14.95 76 71258 1144 42548857
Anti-cyclic citrullinated peptide antibody positive 190.47 14.95 83 71251 1829 42548172
Knee arthroplasty 183.64 14.95 137 71197 8644 42541357
Pulmonary thrombosis 183.02 14.95 134 71200 8214 42541787
Drug tolerance decreased 179.86 14.95 85 71249 2275 42547726
Peripheral swelling 177.73 14.95 436 70898 89834 42460167
Anaemia 175.67 14.95 128 71206 280150 42269851
Limb discomfort 173.63 14.95 155 71179 12612 42537389
Acute kidney injury 167.76 14.95 222 71112 367115 42182886
Therapeutic product effect incomplete 166.33 14.95 367 70967 70572 42479429
Bone cyst 165.54 14.95 72 71262 1579 42548422
Enthesopathy 164.77 14.95 102 71232 4726 42545275
Malignant neoplasm progression 162.39 14.95 4 71330 108396 42441605
Lymphoma 162.17 14.95 157 71177 14164 42535837
Tenosynovitis 159.74 14.95 99 71235 4596 42545405
Constipation 155.38 14.95 40 71294 162251 42387750
Toxicity to various agents 153.74 14.95 97 71237 229039 42320962
Confusional state 151.72 14.95 46 71288 167551 42382450
Terminal state 149.82 14.95 93 71241 4330 42545671
Gastrointestinal disorder 140.84 14.95 268 71066 46385 42503616
Sarcoidosis 139.03 14.95 83 71251 3599 42546402
Joint ankylosis 138.95 14.95 64 71270 1613 42548388
Thrombocytopenia 133.99 14.95 76 71258 190203 42359798
Drug interaction 132.65 14.95 151 71183 266848 42283153
Impaired work ability 132.13 14.95 130 71204 11961 42538040
Swelling 132.08 14.95 287 71047 54598 42495403
Herpes zoster 129.48 14.95 233 71101 38644 42511357
Dehydration 124.56 14.95 41 71293 141726 42408275
Disease progression 123.69 14.95 43 71291 143613 42406388
Mineral metabolism disorder 123.22 14.95 40 71294 371 42549630
Onychoclasis 122.05 14.95 68 71266 2584 42547417
Inflammation 120.65 14.95 209 71125 33638 42516363
Atlantoaxial instability 120.45 14.95 40 71294 401 42549600
Dislocation of vertebra 120.45 14.95 40 71294 401 42549600
Neutropenia 118.55 14.95 96 71238 199335 42350666
Acne cystic 117.07 14.95 42 71292 540 42549461
Hepatic function abnormal 116.57 14.95 263 71071 51304 42498697
Overdose 115.04 14.95 19 71315 105245 42444756
Foot deformity 114.83 14.95 83 71251 4985 42545016
Psoriasis 112.23 14.95 250 71084 48354 42501647
Spinal instability 107.57 14.95 40 71294 573 42549428
Somnolence 105.71 14.95 52 71282 141053 42408948
Tooth loss 105.63 14.95 73 71261 4081 42545920
Intervertebral disc space narrowing 105.32 14.95 47 71287 1098 42548903
Tongue disorder 103.75 14.95 80 71254 5303 42544698
Drug specific antibody present 103.28 14.95 71 71263 3935 42546066
Vomiting 103.10 14.95 206 71128 289517 42260484
Rheumatoid factor positive 102.77 14.95 42 71292 784 42549217
Joint arthroplasty 102.52 14.95 44 71290 933 42549068
Ankylosing spondylitis 100.59 14.95 88 71246 6968 42543033
Tooth fracture 100.50 14.95 71 71263 4113 42545888
Musculoskeletal discomfort 100.05 14.95 100 71234 9376 42540625
Hip arthroplasty 98.24 14.95 77 71257 5228 42544773
Dizziness 97.72 14.95 167 71167 249087 42300914
Bradycardia 96.65 14.95 14 71320 85470 42464531
Osteolysis 95.98 14.95 65 71269 3515 42546486
Decreased appetite 94.99 14.95 110 71224 193027 42356974
Joint stiffness 94.83 14.95 110 71224 12212 42537789
Intestinal sepsis 92.81 14.95 38 71296 713 42549288
Gait inability 92.05 14.95 149 71185 22684 42527317
Ill-defined disorder 89.61 14.95 123 71211 16173 42533828
Seizure 87.94 14.95 46 71288 120515 42429486
Localised infection 87.71 14.95 137 71197 20236 42529765
Hyperkalaemia 86.84 14.95 15 71319 80443 42469558
Infection 84.08 14.95 391 70943 111677 42438324
Pyrexia 84.04 14.95 357 70977 393685 42156316
Skin ulcer 83.40 14.95 152 71182 25449 42524552
Liver function test increased 81.29 14.95 131 71203 19867 42530134
Hyponatraemia 81.26 14.95 34 71300 101428 42448573
Hepatic enzyme abnormal 80.38 14.95 58 71276 3474 42546527
Alopecia 79.62 14.95 161 71173 29115 42520886
Cytology abnormal 77.49 14.95 28 71306 368 42549633
Epistaxis 77.34 14.95 267 71067 66559 42483442
Hypokalaemia 76.03 14.95 14 71320 71707 42478294
Osteosclerosis 75.94 14.95 41 71293 1463 42548538
Joint range of motion decreased 74.91 14.95 78 71256 7675 42542326
Agitation 73.95 14.95 10 71324 64304 42485697
Cardiac arrest 73.59 14.95 46 71288 109274 42440727
Photosensitivity reaction 73.06 14.95 98 71236 12604 42537397
Rheumatoid lung 72.63 14.95 34 71300 890 42549111
Tendonitis 72.27 14.95 86 71248 9808 42540193
Deep vein thrombosis 71.93 14.95 287 71047 76670 42473331
Intentional overdose 69.89 14.95 4 71330 51452 42498549
Fall 69.41 14.95 184 71150 234336 42315665
Soft tissue swelling 69.04 14.95 31 71303 735 42549266
Muscle spasms 68.07 14.95 305 71029 85739 42464262
Arthritis bacterial 67.68 14.95 65 71269 5803 42544198
Abdominal discomfort 65.07 14.95 274 71060 74981 42475020
Product dose omission issue 63.62 14.95 100 71234 154265 42395736
Ankle deformity 63.46 14.95 21 71313 208 42549793
Rhabdomyolysis 62.69 14.95 26 71308 77993 42472008
Joint lock 62.34 14.95 35 71299 1350 42548651
Abdominal pain 62.17 14.95 142 71192 190329 42359672
Joint effusion 61.82 14.95 62 71272 5835 42544166
Seronegative arthritis 60.77 14.95 33 71301 1191 42548810
Neutrophil count decreased 59.92 14.95 16 71318 63399 42486602
Grip strength decreased 59.88 14.95 49 71285 3539 42546462
International normalised ratio increased 59.07 14.95 6 71328 48162 42501839
Skin laceration 58.38 14.95 93 71241 13965 42536036
Mental status changes 58.05 14.95 3 71331 42112 42507889
Hospitalisation 57.77 14.95 26 71308 74304 42475697
Intentional product misuse 57.77 14.95 16 71318 61884 42488117
Haemorrhage 57.76 14.95 15 71319 60548 42489453
Hallucination 57.27 14.95 13 71321 57494 42492507
Dyspnoea 57.01 14.95 471 70863 442150 42107851
Suicide attempt 55.87 14.95 6 71328 46094 42503907
Pulmonary fibrosis 55.78 14.95 132 71202 26549 42523452
Dysstasia 55.52 14.95 91 71243 13995 42536006
Polyomavirus-associated nephropathy 55.16 14.95 57 71277 5558 42544443
Product use in unapproved indication 55.09 14.95 144 71190 184312 42365689
Pneumonia aspiration 54.77 14.95 9 71325 50069 42499932
Hepatic cirrhosis 54.34 14.95 109 71225 19593 42530408
Dactylitis 54.30 14.95 30 71304 1121 42548880
Musculoskeletal pain 54.19 14.95 150 71184 33190 42516811
Electrocardiogram QT prolonged 53.84 14.95 8 71326 47937 42502064
Pulmonary mass 53.51 14.95 97 71237 16168 42533833
Syncope 51.70 14.95 54 71280 99352 42450649
Undifferentiated connective tissue disease 51.46 14.95 15 71319 93 42549908
Tachycardia 51.36 14.95 56 71278 101031 42448970
Hypoglycaemia 51.33 14.95 18 71316 59836 42490165
Plasma cell myeloma 51.04 14.95 9 71325 47569 42502432
Hyperglycaemia 50.70 14.95 8 71326 45851 42504150
Platelet count decreased 50.51 14.95 97 71237 138484 42411517
Cardiac failure congestive 49.81 14.95 42 71292 85560 42464441
Mass 49.61 14.95 67 71267 8672 42541329
Exposure via body fluid 49.54 14.95 15 71319 108 42549893
Finger deformity 49.43 14.95 32 71302 1603 42548398
Tooth disorder 49.40 14.95 79 71255 11900 42538101
Musculoskeletal disorder 48.98 14.95 58 71276 6580 42543421
Ureaplasma infection 48.75 14.95 23 71311 613 42549388
Tuberculin test positive 48.27 14.95 28 71306 1150 42548851
Delirium 48.22 14.95 14 71320 52505 42497496
Nodule 48.09 14.95 80 71254 12454 42537547
Interstitial lung disease 46.99 14.95 257 71077 78205 42471796
Oral surgery 46.43 14.95 22 71312 592 42549409
Myalgia 45.81 14.95 56 71278 96024 42453977
Neoplasm malignant 44.83 14.95 110 71224 22633 42527368
Cardio-respiratory arrest 44.80 14.95 21 71313 58615 42491386
Prerenal failure 44.37 14.95 35 71299 2398 42547603
Atrial fibrillation 43.97 14.95 106 71228 139487 42410514
Liver disorder 43.77 14.95 156 71178 39488 42510513
Granuloma 43.31 14.95 43 71291 3998 42546003
Fine motor skill dysfunction 42.54 14.95 33 71301 2206 42547795
Respiratory failure 42.20 14.95 95 71239 128037 42421964
Hepatic fibrosis 41.75 14.95 46 71288 4826 42545175
Limb deformity 41.52 14.95 20 71314 559 42549442
Mycobacterium tuberculosis complex test positive 41.44 14.95 28 71306 1508 42548493
X-ray abnormal 40.74 14.95 19 71315 493 42549508
Blood creatine phosphokinase increased 40.65 14.95 15 71319 48323 42501678
Medical device implantation 40.19 14.95 20 71314 601 42549400
Red blood cell sedimentation rate 39.88 14.95 24 71310 1056 42548945
Loss of consciousness 39.78 14.95 58 71276 92296 42457705
Dysarthria 39.63 14.95 9 71325 39798 42510203
Exostosis 39.57 14.95 48 71286 5583 42544418
Abdominal distension 39.56 14.95 37 71297 71698 42478303
Food intolerance 39.53 14.95 28 71306 1628 42548373
Blood glucose increased 39.49 14.95 39 71295 73660 42476341
Therapeutic response decreased 39.47 14.95 144 71190 36868 42513133
Haematemesis 39.09 14.95 3 71331 30196 42519805
Septic shock 39.07 14.95 58 71276 91614 42458387
Physical disability 38.66 14.95 29 71305 1844 42548157
Coma 38.19 14.95 21 71313 53533 42496468
Stent placement 38.18 14.95 46 71288 5314 42544687
Granuloma skin 38.01 14.95 24 71310 1151 42548850
Histoplasmosis 37.62 14.95 28 71306 1759 42548242
Urinary retention 37.40 14.95 12 71322 42202 42507799
End stage renal disease 36.89 14.95 84 71250 16474 42533527
Hepatotoxicity 36.79 14.95 109 71225 25058 42524943
Lactic acidosis 36.49 14.95 15 71319 45246 42504755
Hypocalcaemia 36.37 14.95 4 71330 30169 42519832
Pyopneumothorax 36.11 14.95 10 71324 50 42549951
Synovial cyst 35.90 14.95 32 71302 2597 42547404
Tooth extraction 35.76 14.95 45 71289 5435 42544566
Immobile 35.52 14.95 33 71301 2825 42547176
Dermatitis psoriasiform 35.45 14.95 29 71305 2093 42547908
Skin mass 35.40 14.95 42 71292 4774 42545227
Cerebrovascular accident 35.39 14.95 68 71266 97092 42452909
Diabetes mellitus 34.76 14.95 195 71139 59892 42490109
Pancreatitis acute 34.61 14.95 7 71327 33557 42516444
Hepatic enzyme increased 34.47 14.95 160 71174 45624 42504377
Accidental overdose 33.54 14.95 4 71330 28326 42521675
Full blood count abnormal 33.50 14.95 5 71329 29871 42520130
Polyarthritis 33.44 14.95 42 71292 5062 42544939
Drug use disorder 33.20 14.95 61 71273 10272 42539729
Suicidal ideation 32.76 14.95 20 71314 48141 42501860
Shoulder arthroplasty 32.65 14.95 19 71315 785 42549216
Alanine aminotransferase increased 32.39 14.95 256 71078 88150 42461851
Urinary tract infection 32.37 14.95 74 71260 99210 42450791
Flushing 31.97 14.95 11 71323 37017 42512984
Fibromyalgia 31.91 14.95 36 71298 3877 42546124
Intestinal obstruction 31.74 14.95 4 71330 27154 42522847
Dysphagia 30.99 14.95 46 71288 72673 42477328
Blood parathyroid hormone decreased 30.75 14.95 24 71310 1619 42548382
Metabolic acidosis 30.70 14.95 25 71309 51833 42498168
Obstructive airways disorder 30.57 14.95 3 71331 24756 42525245
Generalised tonic-clonic seizure 30.56 14.95 4 71330 26375 42523626
Coronary artery disease 30.46 14.95 27 71307 53693 42496308
Respiratory distress 30.40 14.95 16 71318 41804 42508197
Foetal exposure during pregnancy 30.34 14.95 21 71313 47290 42502711
Swollen joint count increased 30.19 14.95 13 71321 278 42549723
Skin injury 29.98 14.95 29 71305 2612 42547389
Hypoxia 29.88 14.95 44 71290 69742 42480259
Dysgeusia 29.79 14.95 10 71324 34179 42515822
Elbow operation 29.68 14.95 11 71323 156 42549845
Intervertebral disc degeneration 29.58 14.95 48 71286 7319 42542682
Unresponsive to stimuli 29.51 14.95 8 71326 31395 42518606
Cutaneous B-cell lymphoma 29.35 14.95 9 71325 68 42549933
Carbon dioxide abnormal 29.27 14.95 13 71321 300 42549701
Tuberculosis 29.20 14.95 57 71277 10042 42539959
Degenerative bone disease 29.01 14.95 9 71325 71 42549930
Neck pain 28.87 14.95 113 71221 29901 42520100
Neurotoxicity 28.85 14.95 3 71331 23648 42526353
Shoulder operation 28.78 14.95 22 71312 1439 42548562
Onycholysis 28.75 14.95 19 71315 986 42549015
Pulmonary cavitation 28.73 14.95 21 71313 1283 42548718
Anaphylactic shock 28.65 14.95 3 71331 23514 42526487
Bone marrow oedema 28.59 14.95 18 71316 859 42549142
Wrong technique in product usage process 28.59 14.95 18 71316 42617 42507384
Lacrimal disorder 28.47 14.95 13 71321 321 42549680
Restlessness 28.35 14.95 7 71327 29242 42520759
Haematuria 28.27 14.95 33 71301 57766 42492235
Subdural haematoma 28.06 14.95 3 71331 23135 42526866
Neoplasm progression 27.99 14.95 7 71327 28993 42521008
Renal failure 27.85 14.95 365 70969 143361 42406640
Blood pressure decreased 27.79 14.95 34 71300 58298 42491703
Blood creatinine increased 27.66 14.95 93 71241 109910 42440091
Wrist deformity 27.40 14.95 13 71321 351 42549650
Asthenia 27.13 14.95 320 71014 280473 42269528
Immobilisation syndrome 26.93 14.95 14 71320 462 42549539
Bursitis 26.88 14.95 42 71292 6202 42543799
Hepatic cytolysis 26.86 14.95 6 71328 26838 42523163
Hepatic steatosis 26.82 14.95 88 71246 21360 42528641
Panniculitis 26.76 14.95 25 71309 2156 42547845
Medication error 26.70 14.95 11 71323 33143 42516858
Blood pressure fluctuation 26.45 14.95 102 71232 26806 42523195
Haemoptysis 26.42 14.95 23 71311 46144 42503857
Condition aggravated 26.34 14.95 596 70738 260158 42289843
Disorientation 26.34 14.95 14 71320 36375 42513626
Nightmare 26.25 14.95 5 71329 25007 42524994
Oedema 26.19 14.95 29 71305 51972 42498029
Chills 26.13 14.95 76 71258 93990 42456011
Gastric disorder 26.02 14.95 60 71274 11862 42538139
Ascites 26.00 14.95 34 71300 56644 42493357
Oral disorder 25.97 14.95 36 71298 4776 42545225
Chest pain 25.73 14.95 133 71201 139397 42410604
Gastrointestinal haemorrhage 25.69 14.95 81 71253 97645 42452356
Respiratory arrest 25.32 14.95 8 71326 28416 42521585
Neck deformity 25.14 14.95 9 71325 115 42549886
Depressed level of consciousness 24.99 14.95 26 71308 47944 42502057
Rash maculo-papular 24.91 14.95 16 71318 37487 42512514
Irritability 24.91 14.95 8 71326 28120 42521881
Blood cholesterol abnormal 24.89 14.95 23 71311 1956 42548045
Orthostatic hypotension 24.85 14.95 10 71324 30560 42519441
Altered state of consciousness 24.74 14.95 9 71325 29250 42520751
COVID-19 24.62 14.95 105 71229 115843 42434158
Speech disorder 24.55 14.95 9 71325 29112 42520889
Clonal haematopoiesis 24.35 14.95 10 71324 189 42549812
Enzyme abnormality 24.34 14.95 11 71323 265 42549736
Mycobacterial infection 24.27 14.95 26 71308 2642 42547359
Latent tuberculosis 24.20 14.95 21 71313 1644 42548357
Marginal zone lymphoma 24.20 14.95 9 71325 129 42549872
Intentional product use issue 24.14 14.95 204 71130 71629 42478372
Full blood count decreased 24.10 14.95 3 71331 20557 42529444
Tendon disorder 24.00 14.95 29 71305 3360 42546641
Epilepsy 23.98 14.95 7 71327 26164 42523837
Renal impairment 23.91 14.95 99 71235 110129 42439872
Retinal scar 23.86 14.95 12 71322 369 42549632
Vasculitic rash 23.69 14.95 17 71317 1009 42548992
Hypomagnesaemia 23.68 14.95 9 71325 28479 42521522
Dysphonia 23.63 14.95 9 71325 28441 42521560
Disseminated Bacillus Calmette-Guerin infection 23.49 14.95 11 71323 288 42549713
Hypervolaemia 23.48 14.95 5 71329 23120 42526881
Dry skin 23.21 14.95 28 71306 48310 42501691
Impaired healing 23.18 14.95 72 71262 16981 42533020
Tubulointerstitial nephritis 23.03 14.95 12 71322 31536 42518465
Heart block congenital 22.93 14.95 7 71327 52 42549949
Granulomatous dermatitis 22.82 14.95 11 71323 308 42549693
Ventricular fibrillation 22.68 14.95 11 71323 30112 42519889
Aortic bruit 22.55 14.95 10 71324 230 42549771
C-reactive protein decreased 22.51 14.95 23 71311 2213 42547788
Multiple organ dysfunction syndrome 22.41 14.95 85 71249 96950 42453051
Disturbance in attention 22.34 14.95 11 71323 29855 42520146
Lymphoedema 22.31 14.95 34 71300 4914 42545087
Feeling abnormal 21.79 14.95 195 71139 69591 42480410
Erythema 21.79 14.95 278 71056 108515 42441486
Arthrodesis 21.68 14.95 13 71321 568 42549433
Cerebral haemorrhage 21.59 14.95 20 71314 38946 42511055
Ossicle disorder 21.35 14.95 6 71328 32 42549969
Cartilage injury 21.32 14.95 13 71321 586 42549415
Cytomegalovirus viraemia 21.31 14.95 51 71283 10326 42539675
Pulmonary embolism 21.21 14.95 299 71035 119313 42430688
Cytomegalovirus syndrome 21.18 14.95 8 71326 120 42549881
Anal hypoaesthesia 21.18 14.95 5 71329 11 42549990
Diaphragmatic injury 20.70 14.95 8 71326 128 42549873
Cell-mediated cytotoxicity 20.61 14.95 6 71328 37 42549964
Spina bifida occulta 20.59 14.95 5 71329 13 42549988
Pulmonary toxicity 20.50 14.95 45 71289 8610 42541391
Diabetic ketoacidosis 20.46 14.95 6 71328 22361 42527640
Splenic embolism 20.45 14.95 10 71324 289 42549712
Transient ischaemic attack 20.30 14.95 16 71318 33723 42516278
Memory impairment 20.22 14.95 33 71301 50189 42499812
Fracture 20.19 14.95 43 71291 8060 42541941
Cutaneous symptom 20.13 14.95 11 71323 402 42549599
Soft tissue inflammation 20.10 14.95 8 71326 139 42549862
C-reactive protein 19.95 14.95 7 71327 84 42549917
Vitello-intestinal duct remnant 19.94 14.95 8 71326 142 42549859
Shock 19.93 14.95 12 71322 29109 42520892
Dental caries 19.91 14.95 32 71302 4840 42545161
Ileus 19.72 14.95 4 71330 19135 42530866
Tenderness 19.71 14.95 45 71289 8838 42541163
Hypertension 19.71 14.95 391 70943 166813 42383188
Steatorrhoea 19.60 14.95 14 71320 825 42549176
Accidental exposure to product 19.53 14.95 5 71329 20388 42529613
Paternal drugs affecting foetus 19.26 14.95 6 71328 48 42549953
Diffuse idiopathic skeletal hyperostosis 19.26 14.95 6 71328 48 42549953
Oral pustule 19.24 14.95 9 71325 235 42549766
Lupus-like syndrome 19.16 14.95 25 71309 3129 42546872
Melaena 19.08 14.95 22 71312 38724 42511277
Gait disturbance 19.02 14.95 249 71085 97751 42452250
Fluid retention 19.02 14.95 15 71319 31604 42518397
Retroperitonitis 18.81 14.95 4 71330 4 42549997
Enthesophyte 18.81 14.95 4 71330 4 42549997
Cardiac granuloma 18.81 14.95 4 71330 4 42549997
White blood cell count increased 18.74 14.95 29 71305 45058 42504943
Blood bilirubin increased 18.72 14.95 26 71308 42226 42507775
Hot flush 18.68 14.95 7 71327 22344 42527657
Injury 18.64 14.95 7 71327 22309 42527692
Hypophagia 18.60 14.95 11 71323 26945 42523056
Renal tubular necrosis 18.57 14.95 4 71330 18350 42531651
Product administration error 18.55 14.95 4 71330 18339 42531662
Ventricular tachycardia 18.53 14.95 14 71320 30146 42519855
Off label use 18.52 14.95 877 70457 637458 41912543
Sideroblastic anaemia 18.51 14.95 10 71324 357 42549644
Otospondylomegaepiphyseal dysplasia 18.29 14.95 7 71327 109 42549892
Pulmonary granuloma 18.26 14.95 18 71316 1659 42548342
Erythema elevatum diutinum 18.06 14.95 5 71329 25 42549976
Vitamin B1 decreased 18.02 14.95 10 71324 377 42549624
Head injury 17.97 14.95 6 71328 20576 42529425
Aphthous ulcer 17.91 14.95 34 71300 5867 42544134
Extrapyramidal disorder 17.83 14.95 3 71331 16409 42533592
Lethargy 17.79 14.95 32 71302 46858 42503143
Joint contracture 17.67 14.95 20 71314 2161 42547840
Hernia pain 17.56 14.95 9 71325 288 42549713
Adrenal insufficiency 17.45 14.95 5 71329 18919 42531082
Double stranded DNA antibody positive 17.32 14.95 8 71326 203 42549798
No adverse event 17.30 14.95 24 71310 38997 42511004
Fatigue 17.27 14.95 577 70757 435064 42114937
Clostridium difficile colitis 17.20 14.95 7 71327 21245 42528756
Gastrointestinal infection 17.05 14.95 36 71298 6707 42543294
Pallor 17.00 14.95 14 71320 28872 42521129
Blood potassium increased 16.90 14.95 5 71329 18531 42531470
Treatment noncompliance 16.87 14.95 23 71311 37649 42512352
Nail pitting 16.87 14.95 10 71324 428 42549573
Pruritus 16.75 14.95 219 71115 188552 42361449
Ejection fraction decreased 16.73 14.95 8 71326 22079 42527922
Myoclonus 16.70 14.95 4 71330 17061 42532940
Exposure via father 16.68 14.95 7 71327 140 42549861
Dyskinesia 16.64 14.95 11 71323 25379 42524622
Therapy non-responder 16.60 14.95 149 71185 53210 42496791
Status epilepticus 16.59 14.95 3 71331 15575 42534426
Palpitations 16.43 14.95 38 71296 50759 42499242
Intervertebral disc protrusion 16.22 14.95 48 71286 11024 42538977
Carditis 16.21 14.95 8 71326 236 42549765
Cerebral infarction 16.11 14.95 17 71317 31152 42518849
Emphysema 16.11 14.95 50 71284 11785 42538216
Sudden death 16.08 14.95 4 71330 16625 42533376
Erectile dysfunction 16.05 14.95 11 71323 24902 42525099
Haematoma 15.98 14.95 14 71320 28009 42521992
Oropharyngitis fungal 15.95 14.95 7 71327 157 42549844
Lung adenocarcinoma stage III 15.95 14.95 5 71329 41 42549960
Vision blurred 15.94 14.95 42 71292 53657 42496344
Surgery 15.88 14.95 65 71269 17551 42532450
Back pain 15.86 14.95 329 71005 141447 42408554
Dyspnoea exertional 15.83 14.95 38 71296 50110 42499891
Lymphocyte count decreased 15.73 14.95 14 71320 27795 42522206
Motor dysfunction 15.63 14.95 39 71295 8107 42541894
Chronic kidney disease 15.56 14.95 35 71299 47206 42502795
Lung squamous cell carcinoma stage III 15.54 14.95 5 71329 45 42549956
Acute myeloid leukaemia 15.47 14.95 9 71325 22247 42527754
Sensitivity to weather change 15.32 14.95 18 71316 2025 42547976
Unevaluable event 15.29 14.95 21 71313 34267 42515734
Bursitis infective 15.27 14.95 11 71323 657 42549344
Neutrophil count increased 15.27 14.95 7 71327 19797 42530204
Deformity 15.26 14.95 16 71318 1586 42548415
Acute respiratory failure 15.21 14.95 26 71308 38832 42511169
Skin necrosis 15.15 14.95 33 71301 6281 42543720
Empyema 15.13 14.95 26 71308 4154 42545847
Lymphoma transformation 15.08 14.95 10 71324 522 42549479
Lipids increased 15.07 14.95 14 71320 1198 42548803
Headache 15.06 14.95 515 70819 238854 42311147
Disseminated tuberculosis 15.05 14.95 21 71313 2803 42547198
Aphasia 15.03 14.95 11 71323 24072 42525929
Blood pressure systolic increased 15.01 14.95 89 71245 27879 42522122

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug intolerance 4712.45 13.95 7979 572072 398533 109610715
Joint swelling 4445.29 13.95 8160 571891 434685 109574563
Synovitis 4032.53 13.95 6003 574048 268089 109741159
Contraindicated product administered 3628.95 13.95 5422 574629 242845 109766403
Drug ineffective 3598.78 13.95 16586 563465 1503954 108505294
Arthropathy 3103.34 13.95 5473 574578 282049 109727199
Treatment failure 2774.15 13.95 5107 574944 272127 109737121
Therapeutic product effect decreased 2566.20 13.95 4597 575454 239719 109769529
Hand deformity 2333.61 13.95 4142 575909 214364 109794884
Rheumatoid arthritis 2282.04 13.95 4925 575126 294688 109714560
Pemphigus 2095.27 13.95 3913 576138 210657 109798591
Acute kidney injury 2039.92 13.95 425 579626 635005 109374243
Swelling 2022.67 13.95 5174 574877 345867 109663381
Systemic lupus erythematosus 2017.10 13.95 4251 575800 250087 109759161
Glossodynia 1925.86 13.95 3851 576200 218153 109791095
Anti-cyclic citrullinated peptide antibody positive 1896.65 13.95 3414 576637 178570 109830678
Death 1859.65 13.95 673 579378 698196 109311052
Alopecia 1732.55 13.95 5008 575043 359745 109649503
Abdominal discomfort 1724.10 13.95 5253 574798 388605 109620643
Hepatic enzyme increased 1667.13 13.95 4552 575499 316340 109692908
Arthralgia 1626.21 13.95 8224 571827 771408 109237840
Pericarditis 1597.84 13.95 3541 576510 215573 109793675
Musculoskeletal stiffness 1577.36 13.95 4092 575959 275730 109733518
C-reactive protein abnormal 1558.76 13.95 2592 577459 127103 109882145
Psoriatic arthropathy 1541.00 13.95 3273 576778 193488 109815760
Rheumatoid factor positive 1536.98 13.95 2597 577454 129043 109880205
Hypotension 1524.76 13.95 430 579621 523419 109485829
Febrile neutropenia 1478.42 13.95 39 580012 316728 109692520
Wound 1468.37 13.95 3569 576482 230868 109778380
Toxicity to various agents 1465.94 13.95 359 579692 480196 109529052
Drug interaction 1430.94 13.95 424 579627 499759 109509489
Duodenal ulcer perforation 1427.47 13.95 2987 577064 174713 109834535
Anaemia 1412.27 13.95 552 579499 546534 109462714
Helicobacter infection 1410.94 13.95 3014 577037 178863 109830385
Hypersensitivity 1374.02 13.95 4948 575103 399050 109610198
Folliculitis 1348.77 13.95 2820 577231 164833 109844415
Peripheral swelling 1341.51 13.95 4910 575141 399124 109610124
Pain 1320.13 13.95 9039 571012 945916 109063332
Drug hypersensitivity 1296.42 13.95 5260 574791 448830 109560418
Impaired healing 1211.47 13.95 2976 577075 193741 109815507
Irritable bowel syndrome 1175.42 13.95 2635 577416 161580 109847668
Constipation 1166.16 13.95 230 579821 357556 109651692
Completed suicide 1165.49 13.95 21 580030 242360 109766888
Muscle injury 1110.89 13.95 2350 577701 138457 109870791
Mobility decreased 1077.22 13.95 3209 576842 234213 109775035
Infusion related reaction 960.30 13.95 4252 575799 376910 109632338
Osteoarthritis 949.44 13.95 2593 577458 180030 109829218
Gastrointestinal disorder 947.83 13.95 3108 576943 238844 109770404
Fibromyalgia 944.27 13.95 2482 577569 168427 109840821
Red blood cell sedimentation rate abnormal 939.87 13.95 879 579172 23630 109985618
Ill-defined disorder 922.34 13.95 2332 577719 154521 109854727
Neutropenia 917.66 13.95 408 579643 374212 109635036
Blister 916.98 13.95 2950 577101 224426 109784822
Lower respiratory tract infection 915.94 13.95 3082 576969 240024 109769224
Discomfort 899.03 13.95 2822 577229 211885 109797363
Sleep disorder due to general medical condition, insomnia type 895.14 13.95 1816 578235 103827 109905421
Malignant neoplasm progression 885.29 13.95 5 580046 174562 109834686
Red blood cell sedimentation rate increased 863.85 13.95 1507 578544 76795 109932453
Dehydration 845.46 13.95 212 579839 279299 109729949
Hyponatraemia 842.01 13.95 83 579968 217570 109791678
Disease progression 831.29 13.95 140 579911 243894 109765354
C-reactive protein increased 828.15 13.95 2771 577280 215148 109794100
Inflammation 827.58 13.95 2560 577491 190678 109818570
Rheumatic fever 803.07 13.95 1900 578151 120679 109888569
Somnolence 795.45 13.95 283 579768 297166 109712082
Stomatitis 785.46 13.95 3150 576901 267092 109742156
Joint range of motion decreased 766.45 13.95 1859 578192 119973 109889275
Thrombocytopenia 760.22 13.95 443 579608 348442 109660806
Cardiac arrest 753.34 13.95 78 579973 196675 109812573
Seizure 731.37 13.95 137 579914 221048 109788200
Blood cholesterol increased 722.76 13.95 2373 577678 182412 109826836
Infection 721.36 13.95 3777 576274 358423 109650825
Therapeutic product effect incomplete 714.83 13.95 2688 577363 221117 109788131
Bradycardia 704.11 13.95 25 580026 155492 109853756
Maternal exposure during pregnancy 695.58 13.95 2914 577137 251969 109757279
Type 2 diabetes mellitus 688.66 13.95 2271 577780 174961 109834287
Rash 664.79 13.95 6899 573152 814065 109195183
Bone erosion 650.44 13.95 995 579056 45376 109963872
Tremor 633.91 13.95 142 579909 202090 109807158
Intentional overdose 626.71 13.95 14 580037 132487 109876761
Hyperkalaemia 597.31 13.95 27 580024 135769 109873479
Product dose omission issue 595.48 13.95 488 579563 321294 109687954
Grip strength decreased 587.27 13.95 1299 578752 78875 109930373
Sepsis 580.67 13.95 517 579534 326829 109682419
Facet joint syndrome 577.72 13.95 1448 578603 95380 109913868
Atrial fibrillation 576.52 13.95 241 579810 229401 109779847
Swollen joint count increased 572.12 13.95 1319 578732 82342 109926906
Sinusitis 569.99 13.95 3064 576987 293624 109715624
Loss of personal independence in daily activities 568.19 13.95 1906 578145 148114 109861134
Fall 531.21 13.95 1522 578529 601960 109407288
Respiratory failure 530.94 13.95 232 579819 215100 109794148
Platelet count decreased 521.40 13.95 279 579772 230164 109779084
Bursitis 510.13 13.95 1671 578380 128247 109881001
Lip dry 505.81 13.95 1407 578644 98676 109910572
Overdose 501.81 13.95 302 579749 233492 109775756
Rheumatoid nodule 496.42 13.95 572 579479 19724 109989524
Liver injury 487.03 13.95 1815 578236 148598 109860650
Arthritis 483.75 13.95 1950 578101 165636 109843612
Electrocardiogram QT prolonged 481.39 13.95 21 580030 108939 109900309
Product use issue 474.83 13.95 3028 577023 308667 109700581
Musculoskeletal pain 466.32 13.95 2050 578001 180973 109828275
Neutrophil count decreased 465.33 13.95 47 580004 120894 109888354
Dyspnoea 461.97 13.95 3658 576393 1103214 108906034
Breast cancer stage III 461.34 13.95 1173 578878 77944 109931304
Gait inability 457.80 13.95 1665 578386 134711 109874537
Night sweats 457.58 13.95 1645 578406 132338 109876910
Hypokalaemia 444.36 13.95 200 579851 182248 109827000
Cerebrovascular accident 437.97 13.95 201 579850 181083 109828165
Hypoglycaemia 436.77 13.95 49 580002 116055 109893193
Depressed level of consciousness 436.26 13.95 42 580009 112236 109897012
Suicide attempt 425.70 13.95 30 580021 103364 109905884
Rhabdomyolysis 421.28 13.95 64 579987 120337 109888911
Nasopharyngitis 420.12 13.95 3517 576534 390844 109618404
Injury 416.06 13.95 1938 578113 175327 109833921
Wound infection 411.72 13.95 1277 578774 95188 109914060
Urinary tract infection 411.19 13.95 673 579378 325609 109683639
COVID-19 409.84 13.95 408 579643 244652 109764596
Syncope 404.18 13.95 284 579767 202252 109806996
Hypoxia 403.68 13.95 92 579959 129423 109879825
Knee arthroplasty 400.79 13.95 984 579067 63964 109945284
Cardiac failure 398.92 13.95 245 579806 187381 109821867
Gastrointestinal haemorrhage 397.55 13.95 185 579866 165333 109843915
Pulmonary embolism 395.71 13.95 326 579725 214148 109795100
Cardio-respiratory arrest 395.32 13.95 66 579985 115770 109893478
Lactic acidosis 393.78 13.95 23 580028 92788 109916460
Metabolic acidosis 393.71 13.95 35 580016 99709 109909539
Agitation 393.48 13.95 61 579990 112990 109896258
Sciatica 389.56 13.95 1218 578833 91181 109918067
Foot deformity 387.66 13.95 814 579237 47666 109961582
Sleep disorder 384.96 13.95 2057 577994 196587 109812661
Tachycardia 375.95 13.95 380 579671 226265 109782983
Condition aggravated 374.24 13.95 5666 574385 729170 109280078
Peripheral venous disease 373.40 13.95 1129 578922 82988 109926260
Finger deformity 372.81 13.95 643 579408 32449 109976799
Hallucination 371.18 13.95 47 580004 101385 109907863
Vision blurred 370.82 13.95 108 579943 128914 109880334
Adverse event 369.00 13.95 1333 578718 107476 109901772
Pneumonia aspiration 367.86 13.95 13 580038 81220 109928028
Pulmonary fibrosis 363.09 13.95 1270 578781 100772 109908476
Chest discomfort 359.97 13.95 234 579817 173614 109835634
Multiple organ dysfunction syndrome 359.07 13.95 173 579878 151537 109857711
Cytokine release syndrome 351.44 13.95 3 580048 70303 109938945
Pancytopenia 349.31 13.95 350 579701 209263 109799985
Coma 347.42 13.95 94 579957 117775 109891473
Sedation 343.55 13.95 4 580047 69679 109939569
Hyperhidrosis 338.98 13.95 290 579761 187008 109822240
Hip arthroplasty 334.24 13.95 836 579215 54977 109954271
Cardiac failure congestive 331.09 13.95 190 579861 150810 109858438
Renal failure 329.99 13.95 422 579629 226152 109783096
Nail disorder 329.49 13.95 851 579200 57084 109952164
White blood cell count decreased 327.15 13.95 434 579617 228956 109780292
Drug tolerance decreased 324.60 13.95 546 579505 26994 109982254
Mental status changes 322.53 13.95 19 580032 76103 109933145
Cognitive disorder 316.72 13.95 42 580009 87469 109921779
Lower limb fracture 316.47 13.95 992 579059 74356 109934892
Urticaria 314.93 13.95 2797 577254 316060 109693188
Deep vein thrombosis postoperative 314.90 13.95 849 579202 58442 109950806
Hyperglycaemia 314.84 13.95 38 580013 85052 109924196
Myalgia 314.83 13.95 423 579628 221958 109787290
Tenosynovitis 310.87 13.95 405 579646 15878 109993370
International normalised ratio increased 310.82 13.95 43 580008 86729 109922519
Liver function test increased 310.66 13.95 1097 578954 87451 109921797
Cough 309.54 13.95 1307 578744 460334 109548914
Dysphagia 306.93 13.95 215 579836 153385 109855863
Osteoporosis 306.87 13.95 1081 578970 86071 109923177
Blood glucose increased 301.69 13.95 159 579892 132337 109876911
Neoplasm progression 300.93 13.95 8 580043 64587 109944661
Hypercholesterolaemia 300.52 13.95 1104 578947 89733 109919515
Intentional product use issue 300.42 13.95 2278 577773 245628 109763620
Disability 295.36 13.95 552 579499 29671 109979577
Dysarthria 293.63 13.95 45 580006 84076 109925172
Unresponsive to stimuli 293.14 13.95 9 580042 63781 109945467
Weight increased 293.09 13.95 3428 576623 416216 109593032
Ascites 293.09 13.95 64 579987 92744 109916504
Balance disorder 291.34 13.95 123 579928 116437 109892811
Serotonin syndrome 288.94 13.95 4 580047 59149 109950099
Pleural effusion 287.84 13.95 304 579747 177405 109831843
Dislocation of vertebra 284.30 13.95 676 579375 43045 109966203
Neuropathy peripheral 283.36 13.95 313 579738 178964 109830284
Chills 281.62 13.95 351 579700 190229 109819019
Blood creatinine increased 277.48 13.95 330 579721 182559 109826689
Renal impairment 276.45 13.95 349 579702 188096 109821152
Plasma cell myeloma 275.14 13.95 13 580038 62923 109946325
Joint stiffness 272.97 13.95 875 579176 66368 109942880
Live birth 272.00 13.95 893 579158 68591 109940657
Blood pressure decreased 269.67 13.95 133 579918 114958 109894290
Obesity 268.61 13.95 1243 578808 112108 109897140
Intentional product misuse 262.95 13.95 188 579863 132716 109876532
Respiratory arrest 261.66 13.95 10 580041 58289 109950959
Contusion 260.98 13.95 2105 577946 231256 109777992
Granuloma skin 259.28 13.95 308 579743 10975 109998273
Pyrexia 257.96 13.95 3246 576805 895019 109114229
Autoimmune disorder 257.60 13.95 843 579208 64640 109944608
Haematochezia 256.64 13.95 143 579908 115381 109893867
Aggression 256.38 13.95 13 580038 59197 109950051
Blood parathyroid hormone decreased 255.25 13.95 329 579722 12760 109996488
Pain in extremity 254.86 13.95 3775 576276 483343 109525905
Septic shock 254.53 13.95 270 579781 157258 109851990
Musculoskeletal disorder 253.49 13.95 439 579612 22225 109987023
Urinary retention 253.23 13.95 33 580018 69650 109939598
Respiratory distress 251.78 13.95 32 580019 68842 109940406
Orthostatic hypotension 251.59 13.95 27 580024 66222 109943026
Adverse reaction 249.62 13.95 508 579543 29086 109980162
Myelosuppression 246.50 13.95 93 579958 94247 109915001
Wrong technique in product usage process 243.95 13.95 77 579974 87271 109921977
Haematuria 243.10 13.95 67 579984 82938 109926310
Encephalopathy 241.97 13.95 63 579988 80992 109928256
Dry mouth 239.75 13.95 1833 578218 198115 109811133
Cerebral haemorrhage 235.53 13.95 31 580020 64937 109944311
Hypoaesthesia 235.09 13.95 2602 577449 311621 109697627
Pulmonary oedema 233.31 13.95 118 579933 100541 109908707
Back injury 233.15 13.95 660 579391 46739 109962509
Haemorrhage 231.38 13.95 136 579915 106556 109902692
Panniculitis 230.76 13.95 343 579708 15239 109994009
Loss of consciousness 230.66 13.95 423 579628 195883 109813365
Restlessness 229.63 13.95 17 580034 56242 109953006
Lethargy 228.69 13.95 102 579949 93474 109915774
Dry skin 225.41 13.95 143 579908 107510 109901738
Rheumatoid lung 224.65 13.95 184 579867 4120 110005128
Haemoglobin decreased 222.28 13.95 622 579429 248105 109761143
Product label confusion 221.37 13.95 414 579637 22263 109986985
Flushing 220.85 13.95 138 579913 104598 109904650
Drug ineffective for unapproved indication 220.32 13.95 133 579918 102705 109906543
Abdominal pain 220.28 13.95 1680 578371 511309 109497939
Onychomadesis 219.90 13.95 631 579420 45032 109964216
Adjustment disorder with depressed mood 218.74 13.95 614 579437 43269 109965979
Disorientation 218.61 13.95 51 580000 70620 109938628
Melaena 217.95 13.95 47 580004 68710 109940538
Blood creatine phosphokinase increased 217.76 13.95 57 579994 73020 109936228
Lung disorder 217.21 13.95 1653 578398 178394 109830854
General physical health deterioration 216.57 13.95 3281 576770 422014 109587234
Altered state of consciousness 215.01 13.95 25 580026 57601 109951647
Cardiogenic shock 208.73 13.95 27 580024 57311 109951937
Pancreatitis acute 208.64 13.95 33 580018 60241 109949007
Blepharospasm 208.49 13.95 698 579353 54153 109955095
Acute myocardial infarction 206.82 13.95 90 579961 83687 109925561
Haemoptysis 206.35 13.95 59 579992 71295 109937953
Onychomycosis 205.86 13.95 553 579498 37978 109971270
Road traffic accident 205.78 13.95 1109 578942 106289 109902959
Disturbance in attention 203.53 13.95 39 580012 61956 109947292
X-ray abnormal 202.58 13.95 546 579505 37571 109971677
Acute respiratory failure 200.32 13.95 72 579979 75188 109934060
Palmar-plantar erythrodysaesthesia syndrome 199.40 13.95 3 580048 41022 109968226
Hypervolaemia 198.90 13.95 16 580035 49444 109959804
Therapeutic response decreased 198.32 13.95 1016 579035 95483 109913765
Chronic obstructive pulmonary disease 197.47 13.95 169 579882 108989 109900259
Dysgeusia 196.68 13.95 61 579990 69924 109939324
Hypomagnesaemia 193.96 13.95 40 580011 60330 109948918
Generalised tonic-clonic seizure 193.72 13.95 28 580023 54652 109954596
Drug reaction with eosinophilia and systemic symptoms 193.64 13.95 94 579957 82001 109927247
Adverse drug reaction 192.18 13.95 1075 578976 104484 109904764
Angioedema 190.08 13.95 143 579908 98357 109910891
Ventricular tachycardia 188.33 13.95 21 580030 49988 109959260
Dyspnoea exertional 187.16 13.95 162 579889 103898 109905350
Liver disorder 185.83 13.95 1331 578720 140912 109868336
Blood bilirubin increased 185.35 13.95 83 579968 75889 109933359
Retinitis 184.98 13.95 476 579575 31851 109977397
Drug eruption 184.94 13.95 661 579390 52998 109956250
Full blood count abnormal 184.57 13.95 35 580016 56017 109953231
Aphasia 183.63 13.95 42 580009 58955 109950293
Exposure during pregnancy 182.66 13.95 1502 578549 165922 109843326
Palpitations 181.80 13.95 349 579702 158863 109850385
Abnormal behaviour 181.24 13.95 5 580046 39034 109970214
Intentional self-injury 180.81 13.95 3 580048 37426 109971822
Hallucination, visual 180.50 13.95 6 580045 39599 109969649
Exostosis 180.18 13.95 591 579460 45365 109963883
Colitis 179.57 13.95 163 579888 102160 109907088
Pneumonia 178.92 13.95 3381 576670 873333 109135915
C-reactive protein 178.11 13.95 451 579600 29880 109979368
Suicidal ideation 177.92 13.95 139 579912 93798 109915450
Haematoma 177.34 13.95 44 580007 58432 109950816
Dizziness 177.02 13.95 2587 577464 695606 109313642
Hepatic cytolysis 175.79 13.95 37 580014 55016 109954232
Enthesopathy 175.29 13.95 268 579783 12210 109997038
Coronary artery disease 173.84 13.95 79 579972 71611 109937637
Mucosal inflammation 172.51 13.95 150 579901 95991 109913257
Drug level increased 172.43 13.95 23 580028 47696 109961552
Joint destruction 172.36 13.95 248 579803 10695 109998553
Neurotoxicity 171.56 13.95 13 580038 42194 109967054
Chronic kidney disease 171.53 13.95 93 579958 76198 109933050
Cerebral infarction 171.48 13.95 32 580019 51806 109957442
Psychotic disorder 169.45 13.95 31 580020 50906 109958342
Inappropriate schedule of product administration 167.65 13.95 529 579522 203108 109806140
Obstructive airways disorder 167.34 13.95 22 580029 46127 109963121
Arrhythmia 166.65 13.95 78 579973 69497 109939751
Prescribed overdose 166.17 13.95 902 579149 86679 109922569
Lymphocyte count decreased 166.14 13.95 47 580004 57196 109952052
Dyskinesia 165.46 13.95 34 580017 51412 109957836
Rash erythematous 164.17 13.95 114 579937 81718 109927530
Deep vein thrombosis 163.80 13.95 302 579749 139585 109869663
Cholestasis 162.96 13.95 67 579984 64451 109944797
Urinary incontinence 162.86 13.95 29 580022 48558 109960690
Inappropriate antidiuretic hormone secretion 162.34 13.95 3 580048 33848 109975400
Toxic epidermal necrolysis 162.02 13.95 48 580003 56679 109952569
Nausea 159.63 13.95 5104 574947 1230586 108778662
Ventricular fibrillation 159.03 13.95 16 580035 41297 109967951
Agranulocytosis 157.84 13.95 63 579988 61697 109947551
Apparent death 157.66 13.95 127 579924 2775 110006473
Coeliac disease 157.47 13.95 542 579509 42645 109966603
Ejection fraction decreased 156.93 13.95 16 580035 40864 109968384
Circulatory collapse 154.69 13.95 21 580030 42972 109966276
Pallor 153.76 13.95 52 579999 56415 109952833
Abdominal pain upper 153.52 13.95 2629 577422 346482 109662766
Tuberculin test positive 153.16 13.95 138 579913 3530 110005718
Subdural haematoma 151.73 13.95 10 580041 36444 109972804
Prescribed underdose 151.64 13.95 711 579340 64463 109944785
Rheumatoid factor negative 151.62 13.95 91 579960 1209 110008039
Vomiting 151.59 13.95 3629 576422 907046 109102202
Clostridium difficile colitis 151.46 13.95 24 580027 43754 109965494
Blood calcium decreased 148.70 13.95 10 580041 35835 109973413
Myocardial infarction 147.78 13.95 514 579537 191569 109817679
Sinus tachycardia 146.03 13.95 28 580023 44465 109964783
Drug withdrawal syndrome 145.80 13.95 15 580036 38039 109971209
Diabetic ketoacidosis 145.63 13.95 23 580028 42035 109967213
Blood urea increased 145.54 13.95 53 579998 54904 109954344
Deformity 145.25 13.95 220 579831 9940 109999308
Dysuria 145.07 13.95 67 579984 60164 109949084
Bacteraemia 144.95 13.95 24 580027 42366 109966882
Oxygen saturation decreased 144.37 13.95 387 579664 156595 109852653
Transient ischaemic attack 142.38 13.95 79 579972 63903 109945345
Premature delivery 141.92 13.95 4 580047 30628 109978620
Eosinophilia 140.23 13.95 64 579987 57872 109951376
Nodule 140.12 13.95 433 579618 32198 109977050
Shock 139.70 13.95 53 579998 53535 109955713
Lupus-like syndrome 139.29 13.95 501 579550 40291 109968957
Full blood count decreased 139.12 13.95 7 580044 32092 109977156
Pericardial effusion 138.81 13.95 63 579988 57154 109952094
Acute myeloid leukaemia 138.59 13.95 18 580033 38092 109971156
Lupus vulgaris 138.49 13.95 442 579609 33441 109975807
Hypophosphataemia 138.41 13.95 9 580042 33173 109976075
Skin necrosis 138.10 13.95 331 579720 21181 109988067
Cardiac disorder 138.08 13.95 118 579933 76162 109933086
Accidental overdose 137.25 13.95 50 580001 51784 109957464
Seronegative arthritis 136.73 13.95 247 579804 12930 109996318
Sinus bradycardia 136.04 13.95 4 580047 29479 109979769
Bone pain 135.68 13.95 87 579964 65046 109944202
Upper gastrointestinal haemorrhage 134.91 13.95 47 580004 50049 109959199
Presyncope 134.90 13.95 44 580007 48843 109960405
Limb deformity 133.42 13.95 129 579922 3617 110005631
Tinnitus 132.92 13.95 76 579975 60464 109948784
Neck pain 132.86 13.95 1102 578949 122028 109887220
Tumour lysis syndrome 132.60 13.95 7 580044 30794 109978454
Skin exfoliation 132.00 13.95 159 579892 87492 109921756
Irritability 131.98 13.95 43 580008 47766 109961482
Hypertension 130.73 13.95 3552 576499 506532 109502716
Erythema 130.41 13.95 943 579108 290504 109718744
Withdrawal syndrome 129.46 13.95 9 580042 31371 109977877
Myoclonus 129.07 13.95 12 580039 32986 109976262
Off label use 129.01 13.95 6496 573555 1493689 108515559
Haematemesis 128.64 13.95 75 579976 59033 109950215
Intestinal obstruction 128.52 13.95 59 579992 53168 109956080
Cholelithiasis 127.69 13.95 88 579963 63334 109945914
Status epilepticus 127.54 13.95 10 580041 31561 109977687
Poisoning 127.26 13.95 6 580045 29099 109980149
Ankylosing spondylitis 126.96 13.95 264 579787 15348 109993900
Respiratory depression 126.89 13.95 11 580040 31990 109977258
Injection site pain 126.43 13.95 492 579559 177430 109831818
Ileus 126.23 13.95 9 580042 30720 109978528
Tubulointerstitial nephritis 125.24 13.95 64 579987 54220 109955028
Labelled drug-drug interaction medication error 125.09 13.95 7 580044 29295 109979953
Fluid retention 124.86 13.95 188 579863 94119 109915129
Oedema peripheral 123.80 13.95 1114 578937 327546 109681702
Metastases to liver 123.32 13.95 19 580032 35367 109973881
Skin ulcer 123.11 13.95 659 579392 62986 109946262
Product administration error 123.05 13.95 23 580028 37194 109972054
Depressed mood 122.92 13.95 84 579967 60725 109948523
Stevens-Johnson syndrome 122.91 13.95 46 580005 46855 109962393
Incorrect dose administered 122.88 13.95 222 579829 103419 109905829
Anti-cyclic citrullinated peptide antibody 122.63 13.95 302 579749 19662 109989586
Ear pain 122.61 13.95 579 579472 52647 109956601
Therapy interrupted 122.21 13.95 54 579997 49768 109959480
Hemiparesis 122.05 13.95 39 580012 43864 109965384
Right ventricular failure 121.70 13.95 3 580048 25951 109983297
Heart rate increased 121.66 13.95 369 579682 143465 109865783
Blood potassium decreased 121.60 13.95 66 579985 54048 109955200
Hypocalcaemia 120.93 13.95 99 579952 65267 109943981
Joint effusion 120.83 13.95 309 579742 20596 109988652
Haemorrhage intracranial 120.41 13.95 8 580043 28961 109980287
Nightmare 120.28 13.95 28 580023 38835 109970413
Product prescribing error 119.20 13.95 60 579991 51271 109957977
Pregnancy 118.72 13.95 557 579494 50510 109958738
Blood sodium decreased 117.82 13.95 28 580023 38291 109970957
Lip swelling 116.50 13.95 60 579991 50607 109958641
Head injury 116.46 13.95 40 580011 42977 109966271
Diarrhoea 115.34 13.95 4847 575204 1134658 108874590
Accidental exposure to product 115.31 13.95 59 579992 49949 109959299
Device dislocation 115.23 13.95 15 580036 31689 109977559
Hyperbilirubinaemia 115.19 13.95 13 580038 30658 109978590
Dementia 115.08 13.95 15 580036 31658 109977590
Injection site reaction 114.88 13.95 831 579220 88239 109921009
Leukocytosis 114.75 13.95 70 579981 53758 109955490
Coordination abnormal 114.34 13.95 4 580047 25224 109984024
Oral mucosal exfoliation 113.94 13.95 83 579968 1553 110007695
Hepatitis 113.75 13.95 836 579215 89218 109920030
Metastases to bone 113.64 13.95 15 580036 31357 109977891
Angina pectoris 113.21 13.95 96 579955 62199 109947049
Hypothermia 113.16 13.95 6 580045 26296 109982952
Small intestinal obstruction 112.94 13.95 17 580034 32196 109977052
Therapy cessation 112.61 13.95 47 580004 44810 109964438
Joint laxity 112.00 13.95 98 579953 2409 110006839
Vertigo 111.35 13.95 177 579874 86693 109922555
Tachypnoea 111.30 13.95 34 580017 39361 109969887
Disseminated intravascular coagulation 110.72 13.95 39 580012 41247 109968001
Dystonia 110.67 13.95 6 580045 25799 109983449
Bone marrow failure 110.30 13.95 85 579966 57763 109951485
Epistaxis 109.88 13.95 335 579716 130037 109879211
Musculoskeletal deformity 108.64 13.95 79 579972 1474 110007774
Flatulence 108.16 13.95 70 579981 52079 109957169
Hallucination, auditory 107.66 13.95 8 580043 26389 109982859
Anxiety 107.45 13.95 1224 578827 343854 109665394
Extrapyramidal disorder 106.51 13.95 13 580038 28854 109980394
Red blood cell sedimentation rate 106.31 13.95 134 579917 5080 110004168
Cellulitis 105.35 13.95 325 579726 125691 109883557
Hepatic failure 105.31 13.95 123 579928 68616 109940632
Pollakiuria 105.14 13.95 50 580001 44145 109965103
Dysphonia 104.80 13.95 147 579904 75782 109933466
Torsade de pointes 104.52 13.95 3 580048 22597 109986651
Rash maculo-papular 104.14 13.95 142 579909 74080 109935168
Swollen tongue 103.72 13.95 98 579953 60264 109948984
Troponin increased 103.69 13.95 16 580035 29750 109979498
Productive cough 103.42 13.95 284 579767 114021 109895227
Diplopia 103.40 13.95 45 580006 41849 109967399
Paranoia 103.37 13.95 3 580048 22371 109986877
Oropharyngeal pain 103.35 13.95 363 579688 134913 109874335
Hypophagia 103.34 13.95 75 579976 52551 109956697
Alanine aminotransferase abnormal 103.33 13.95 180 579871 9154 110000094
Swelling face 103.09 13.95 205 579846 92116 109917132
Hypothyroidism 102.76 13.95 139 579912 72760 109936488
Renal tubular necrosis 102.55 13.95 18 580033 30457 109978791
Parkinsonism 102.41 13.95 3 580048 22184 109987064
Muscle twitching 102.24 13.95 17 580034 29918 109979330
Muscle rigidity 101.79 13.95 6 580045 24025 109985223
Neutropenic sepsis 101.65 13.95 19 580032 30727 109978521
Cytomegalovirus infection 101.28 13.95 82 579969 54362 109954886
Gastritis 101.00 13.95 80 579971 53619 109955629
Ischaemic stroke 100.78 13.95 45 580006 41218 109968030
Myocarditis 100.60 13.95 18 580033 30037 109979211
Creatinine renal clearance decreased 100.51 13.95 3 580048 21812 109987436
Dyspepsia 100.42 13.95 1482 578569 189483 109819765
Drug tolerance 99.88 13.95 249 579802 16336 109992912
Mitral valve incompetence 99.29 13.95 26 580025 33303 109975945
Pulmonary hypertension 99.24 13.95 86 579965 55134 109954114
Taste disorder 98.58 13.95 634 579417 64753 109944495
Therapy non-responder 98.28 13.95 1259 578792 156048 109853200
Dermatitis atopic 98.03 13.95 10 580041 25531 109983717
Wheezing 97.35 13.95 1880 578171 253350 109755898
Feeling abnormal 96.47 13.95 554 579497 180157 109829091
Shock haemorrhagic 96.40 13.95 14 580037 27233 109982015
Joint arthroplasty 95.56 13.95 105 579946 3432 110005816
Joint dislocation 95.50 13.95 394 579657 33796 109975452
Mydriasis 95.50 13.95 5 580046 22152 109987096
Paraesthesia oral 95.23 13.95 29 580022 33642 109975606
Cyanosis 94.93 13.95 20 580031 29721 109979527
Anuria 94.81 13.95 9 580042 24332 109984916
Hepatic encephalopathy 94.41 13.95 17 580034 28239 109981009
Electrolyte imbalance 94.24 13.95 38 580013 36990 109972258
Laryngitis 93.81 13.95 456 579595 41955 109967293
Infusion site reaction 93.66 13.95 253 579798 17429 109991819
Haemodynamic instability 93.17 13.95 7 580044 22881 109986367
Hepatic cirrhosis 92.49 13.95 640 579411 66986 109942262
Maternal exposure timing unspecified 92.23 13.95 281 579770 20732 109988516
Aplastic anaemia 92.05 13.95 10 580041 24298 109984950
Device issue 91.97 13.95 33 580018 34502 109974746
Mania 91.86 13.95 4 580047 20792 109988456
Toxic skin eruption 90.97 13.95 17 580034 27498 109981750
Transfusion 90.33 13.95 13 580038 25459 109983789
Clostridium difficile infection 90.32 13.95 84 579967 52045 109957203
Polyarthritis 90.28 13.95 261 579790 18702 109990546
Impaired quality of life 90.22 13.95 23 580028 29994 109979254
Acute respiratory distress syndrome 89.51 13.95 88 579963 53110 109956138
Speech disorder 89.23 13.95 115 579936 61454 109947794
Acidosis 88.65 13.95 8 580043 22523 109986725
Metastases to lung 88.59 13.95 9 580042 23054 109986194
Cardiac failure acute 88.46 13.95 11 580040 24067 109985181
Left ventricular dysfunction 88.12 13.95 10 580041 23483 109985765
Loose body in joint 87.63 13.95 67 579984 1353 110007895
Thrombosis 87.49 13.95 285 579766 108377 109900871
Abdominal pain lower 87.44 13.95 43 580008 37240 109972008
Asthenia 87.14 13.95 2852 577199 686147 109323101
Bone swelling 87.06 13.95 74 579977 1747 110007501
Atrial flutter 86.93 13.95 12 580039 24250 109984998
Lacrimation increased 86.92 13.95 27 580024 30923 109978325
Hyperthyroidism 86.84 13.95 23 580028 29238 109980010
Weight decreased 86.78 13.95 1833 578218 466224 109543024
Foot operation 86.19 13.95 145 579906 7168 110002080
Malnutrition 85.73 13.95 19 580032 27260 109981988
Hypoalbuminaemia 85.56 13.95 23 580028 28951 109980297
Acute generalised exanthematous pustulosis 84.41 13.95 8 580043 21656 109987592
Chronic sinusitis 84.01 13.95 15 580036 25069 109984179
Bronchopulmonary aspergillosis 83.96 13.95 26 580025 29837 109979411
Impaired work ability 83.92 13.95 317 579734 26102 109983146
Appendicitis 83.29 13.95 23 580028 28441 109980807
Ataxia 83.25 13.95 27 580024 30081 109979167
Supraventricular tachycardia 83.12 13.95 14 580037 24408 109984840
Eczema 82.91 13.95 158 579893 72135 109937113
Activated partial thromboplastin time prolonged 82.71 13.95 10 580041 22358 109986890
Metastases to central nervous system 82.43 13.95 11 580040 22806 109986442
Delusion 82.23 13.95 13 580038 23742 109985506
Atrioventricular block complete 82.15 13.95 6 580045 20076 109989172
Procedural pain 81.94 13.95 42 580009 35523 109973725
Lymphopenia 81.85 13.95 55 579996 40115 109969133
Subarachnoid haemorrhage 81.48 13.95 27 580024 29675 109979573
Bacterial infection 81.16 13.95 73 579978 45963 109963285
Chest pain 81.03 13.95 1437 578614 374938 109634310
Arthrodesis 81.03 13.95 85 579966 2633 110006615
Face oedema 80.96 13.95 37 580014 33432 109975816
Shoulder arthroplasty 80.48 13.95 97 579954 3510 110005738
Pemphigoid 80.29 13.95 6 580045 19701 109989547
Lower gastrointestinal haemorrhage 80.22 13.95 4 580047 18482 109990766
Prostate cancer 80.17 13.95 49 580002 37592 109971656
Influenza 79.59 13.95 539 579512 168562 109840686
Jaundice 79.46 13.95 117 579934 59119 109950129
Peritonitis 78.94 13.95 36 580015 32571 109976677
Blood glucose decreased 78.83 13.95 28 580023 29460 109979788
Electrocardiogram abnormal 78.25 13.95 5 580046 18704 109990544
Surgical failure 78.11 13.95 53 579998 881 110008367
Emotional distress 78.01 13.95 72 579979 44775 109964473
Hyperlipidaemia 77.28 13.95 46 580005 35802 109973446
International normalised ratio fluctuation 77.13 13.95 101 579950 3979 110005269
Faeces discoloured 76.87 13.95 41 580010 33907 109975341
Arteriosclerosis coronary artery 75.97 13.95 19 580032 25099 109984149
Visual acuity reduced 75.62 13.95 37 580014 32136 109977112
Bloody discharge 75.35 13.95 82 579969 2651 110006597
Fear 75.26 13.95 15 580036 23178 109986070
Haemorrhoids 75.19 13.95 47 580004 35625 109973623
Acute coronary syndrome 74.89 13.95 15 580036 23097 109986151
Rectal haemorrhage 74.87 13.95 348 579703 119485 109889763
Product substitution issue 74.66 13.95 15 580036 23046 109986202
Atlantoaxial instability 74.59 13.95 35 580016 270 110008978
Burning sensation 74.46 13.95 157 579894 69055 109940193
Incontinence 74.15 13.95 3 580048 16632 109992616
Porphyria acute 74.04 13.95 242 579809 18538 109990710
Blood magnesium decreased 73.79 13.95 9 580042 19987 109989261
Food allergy 73.56 13.95 9 580042 19939 109989309
Hepatic enzyme abnormal 73.50 13.95 160 579891 9603 109999645
Aspiration 73.47 13.95 34 580017 30499 109978749
Respiratory tract infection 73.30 13.95 167 579884 71450 109937798
Gout 73.26 13.95 51 580000 36515 109972733
Device related infection 72.92 13.95 60 579991 39459 109969789
Hyperphosphataemia 72.86 13.95 3 580048 16378 109992870
Ventricular extrasystoles 72.73 13.95 15 580036 22626 109986622
Mental disorder 72.69 13.95 58 579993 38733 109970515
Neutrophil count increased 72.56 13.95 46 580005 34606 109974642
Aspergillus infection 72.56 13.95 22 580029 25594 109983654
Synovial cyst 72.43 13.95 175 579876 11255 109997993
Cardiomegaly 72.36 13.95 31 580020 29099 109980149
Coagulopathy 71.97 13.95 65 579986 40846 109968402
Hepatocellular injury 71.95 13.95 96 579955 50546 109958702
Drug level decreased 71.87 13.95 7 580044 18541 109990707
Skin discolouration 71.71 13.95 91 579960 48955 109960293
Panic attack 71.56 13.95 31 580020 28909 109980339
Vaginal discharge 71.43 13.95 6 580045 17902 109991346
Proteinuria 71.10 13.95 63 579988 39955 109969293
Posterior reversible encephalopathy syndrome 70.84 13.95 45 580006 33816 109975432
Neuralgia 70.82 13.95 90 579961 48388 109960860
Urine output decreased 70.82 13.95 10 580041 19866 109989382
Device difficult to use 70.55 13.95 8 580043 18797 109990451
Blood pressure increased 70.38 13.95 943 579108 257430 109751818
Eye pain 70.13 13.95 96 579955 50003 109959245
Renal injury 70.10 13.95 8 580043 18705 109990543
Intestinal sepsis 70.07 13.95 51 580000 953 110008295
Immune thrombocytopenia 70.03 13.95 16 580035 22478 109986770
Anaphylactic shock 69.94 13.95 101 579950 51445 109957803
Hemiplegia 69.35 13.95 17 580034 22765 109986483
Ulcer 69.32 13.95 425 579626 42691 109966557
Eye swelling 69.03 13.95 44 580007 33004 109976244
Respiratory disorder 68.70 13.95 623 579428 70759 109938489
Psoriasis 68.02 13.95 1072 578979 138921 109870327
Sleep apnoea syndrome 67.94 13.95 67 579984 40380 109968868
Myopathy 67.93 13.95 23 580028 24937 109984311
Female genital tract fistula 67.39 13.95 5 580046 16514 109992734
Sudden death 67.23 13.95 22 580029 24373 109984875
Nasal congestion 67.12 13.95 276 579775 98006 109911242
Mental impairment 66.79 13.95 18 580033 22621 109986627
Wrist deformity 66.68 13.95 83 579968 3106 110006142
Physical disability 66.61 13.95 106 579945 5000 110004248
Eye pruritus 66.61 13.95 45 580006 32730 109976518
Oesophagitis 66.02 13.95 34 580017 28681 109980567
Diabetes mellitus inadequate control 65.90 13.95 37 580014 29738 109979510
Neurological symptom 65.80 13.95 4 580047 15604 109993644
Blood iron abnormal 65.60 13.95 58 579993 1446 110007802
Cardiomyopathy 65.53 13.95 48 580003 33477 109975771
Colitis ischaemic 65.47 13.95 8 580043 17742 109991506
Faecaloma 65.42 13.95 3 580048 14905 109994343
Breast cancer stage II 65.40 13.95 301 579750 27074 109982174
Benign prostatic hyperplasia 65.38 13.95 9 580042 18225 109991023
Sensory loss 65.34 13.95 16 580035 21441 109987807
Rash macular 65.08 13.95 64 579987 38622 109970626
Oliguria 65.06 13.95 10 580041 18647 109990601
Thrombotic microangiopathy 64.84 13.95 36 580015 29113 109980135
Rash papular 64.64 13.95 32 580019 27607 109981641
Mineral metabolism disorder 64.63 13.95 35 580016 377 110008871
Erectile dysfunction 64.58 13.95 10 580041 18546 109990702
Pulmonary arterial hypertension 64.48 13.95 46 580005 32522 109976726
Deafness transitory 64.03 13.95 50 580001 1043 110008205
Nephropathy toxic 63.98 13.95 32 580019 27446 109981802
Infusion site pain 63.89 13.95 8 580043 17411 109991837
Influenza like illness 63.74 13.95 243 579808 88169 109921079
Hypotonia 63.57 13.95 5 580046 15740 109993508
Cholecystitis 63.56 13.95 28 580023 25854 109983394
Joint injury 63.52 13.95 393 579658 39601 109969647
Ankle deformity 63.16 13.95 42 580009 674 110008574
Enteritis 62.98 13.95 12 580039 19144 109990104
Haemodialysis 62.93 13.95 9 580042 17710 109991538
Chromaturia 62.83 13.95 38 580013 29322 109979926
Hot flush 62.82 13.95 160 579891 65876 109943372
Blindness 62.50 13.95 59 579992 36300 109972948
Tendonitis 62.47 13.95 287 579764 25796 109983452
Vaginal haemorrhage 61.78 13.95 27 580024 25047 109984201
Bone cyst 61.71 13.95 85 579966 3518 110005730
Brain oedema 61.47 13.95 44 580007 31054 109978194
Pulmonary alveolar haemorrhage 61.41 13.95 15 580036 20135 109989113
Atrioventricular block 61.30 13.95 8 580043 16869 109992379
Thirst 60.84 13.95 19 580032 21688 109987560
Bronchospasm 60.81 13.95 42 580009 30197 109979051
Myocardial ischaemia 60.75 13.95 32 580019 26652 109982596
Migraine 60.61 13.95 1250 578801 170402 109838846
Hypersomnia 60.50 13.95 36 580015 28025 109981223
Atelectasis 60.31 13.95 62 579989 36650 109972598
Gastric disorder 60.21 13.95 339 579712 33018 109976230
Anal incontinence 60.19 13.95 20 580031 21944 109987304
Ear infection 60.11 13.95 547 579504 62185 109947063
Enterocolitis 59.95 13.95 13 580038 18936 109990312
Femur fracture 59.72 13.95 419 579632 44050 109965198
Spinal instability 59.57 13.95 35 580016 446 110008802
Vascular device infection 59.56 13.95 8 580043 16504 109992744
Decreased appetite 59.52 13.95 1972 578079 473874 109535374
Acute pulmonary oedema 59.51 13.95 9 580042 16987 109992261
Nocturia 59.49 13.95 9 580042 16981 109992267
Salivary hypersecretion 59.26 13.95 10 580041 17411 109991837
Illness 58.49 13.95 227 579824 81944 109927304
Tricuspid valve incompetence 58.35 13.95 26 580025 23847 109985401
Toxic encephalopathy 58.28 13.95 6 580045 15208 109994040
Thyroid neoplasm 58.23 13.95 79 579972 3222 110006026
Myasthenia gravis 58.23 13.95 20 580031 21491 109987757
Eosinophil count increased 58.02 13.95 19 580032 21039 109988209
Intervertebral disc space narrowing 57.79 13.95 60 579991 1836 110007412
Systemic lupus erythematosus rash 57.76 13.95 62 579989 1973 110007275
Myelodysplastic syndrome 57.50 13.95 67 579984 37417 109971831
Complication associated with device 57.29 13.95 17 580034 20056 109989192
Fine motor skill dysfunction 56.87 13.95 111 579940 6163 110003085
Nasal polyps 56.82 13.95 3 580048 13197 109996051
Gait disturbance 56.47 13.95 1883 578168 276325 109732923
Neck deformity 56.26 13.95 59 579992 1827 110007421
Insomnia 56.22 13.95 2370 577681 358220 109651028
Purpura 55.89 13.95 29 580022 24359 109984889
Basal cell carcinoma 55.87 13.95 418 579633 44852 109964396
No adverse event 55.81 13.95 199 579852 73640 109935608
Glycosylated haemoglobin increased 55.76 13.95 27 580024 23592 109985656
Multiple fractures 55.71 13.95 136 579915 8804 110000444
Failure to thrive 55.68 13.95 4 580047 13570 109995678
Chondropathy 55.41 13.95 72 579979 2815 110006433
Hospitalisation 55.35 13.95 479 579572 142014 109867234
Hiccups 55.16 13.95 3 580048 12866 109996382
Renal disorder 55.12 13.95 110 579941 49369 109959879
Abortion spontaneous 55.08 13.95 59 579992 34223 109975025
Terminal state 54.74 13.95 103 579948 5564 110003684
Tongue disorder 54.36 13.95 182 579869 14116 109995132
Mycobacterium tuberculosis complex test positive 53.97 13.95 76 579975 3212 110006036
Apathy 53.76 13.95 10 580041 16229 109993019
Generalised oedema 53.75 13.95 49 580002 30655 109978593
Sensitivity to weather change 53.63 13.95 144 579907 9884 109999364
Bone disorder 53.61 13.95 237 579814 20955 109988293
Walking aid user 53.60 13.95 267 579784 24808 109984440
Exposure via skin contact 53.57 13.95 4 580047 13143 109996105
Asphyxia 53.44 13.95 6 580045 14209 109995039
Ocular hyperaemia 53.28 13.95 77 579974 39209 109970039
Pseudomonas infection 53.00 13.95 41 580010 27812 109981436
Tardive dyskinesia 52.95 13.95 5 580046 13574 109995674
Device leakage 52.88 13.95 10 580041 16038 109993210
Pyelonephritis 52.22 13.95 34 580017 25216 109984032
Gangrene 52.13 13.95 11 580040 16330 109992918
Blood loss anaemia 51.93 13.95 15 580036 18010 109991238
Dialysis 51.81 13.95 19 580032 19600 109989648
Hepatitis cholestatic 51.76 13.95 14 580037 17552 109991696
Stress cardiomyopathy 51.76 13.95 10 580041 15796 109993452
Enterococcal infection 51.67 13.95 21 580030 20345 109988903
Blood potassium increased 51.46 13.95 59 579992 33190 109976058
Coronary artery stenosis 51.24 13.95 6 580045 13752 109995496
Ankle arthroplasty 51.12 13.95 65 579986 2486 110006762
Macular degeneration 50.76 13.95 25 580026 21634 109987614
Osteonecrosis of jaw 50.75 13.95 110 579941 47907 109961341
Sinus disorder 50.74 13.95 58 579993 32670 109976578
Hyperthermia 50.70 13.95 24 580027 21248 109988000
Polyuria 50.67 13.95 15 580036 17723 109991525
Pulmonary haemorrhage 50.64 13.95 12 580039 16444 109992804
Nervous system disorder 50.51 13.95 55 579996 31666 109977582
Retching 50.47 13.95 28 580023 22654 109986594
Prothrombin time prolonged 50.41 13.95 14 580037 17247 109992001
Eructation 50.25 13.95 7 580044 14050 109995198
Hospice care 50.25 13.95 4 580047 12469 109996779
Joint space narrowing 50.16 13.95 39 580012 808 110008440
Cholangitis 50.10 13.95 12 580039 16323 109992925
Respiratory symptom 49.91 13.95 9 580042 14936 109994312
Diastolic dysfunction 49.91 13.95 4 580047 12400 109996848
Brain injury 49.89 13.95 6 580045 13470 109995778
Embolism 49.89 13.95 12 580039 16277 109992971
Bladder cancer 49.76 13.95 22 580029 20270 109988978
Epstein-Barr virus infection 49.73 13.95 18 580033 18720 109990528
Skin toxicity 49.73 13.95 3 580048 11780 109997468
Rhinitis allergic 49.68 13.95 16 580035 17906 109991342
Arthritis bacterial 49.67 13.95 147 579904 10673 109998575
Bone density abnormal 49.51 13.95 80 579971 3823 110005425
Ileus paralytic 49.50 13.95 3 580048 11734 109997514
Device malfunction 49.43 13.95 37 580014 25521 109983727
Escherichia infection 49.34 13.95 32 580019 23784 109985464
Sensory disturbance 49.31 13.95 15 580036 17414 109991834
Spinal column injury 49.27 13.95 61 579990 2270 110006978
Abscess 49.09 13.95 43 580008 27426 109981822
Pneumonia fungal 49.03 13.95 9 580042 14745 109994503
Pneumothorax 49 13.95 68 579983 35217 109974031
Cystitis haemorrhagic 48.95 13.95 4 580047 12205 109997043
Therapy partial responder 48.93 13.95 74 579977 36987 109972261
Limb discomfort 48.61 13.95 374 579677 40480 109968768
Klebsiella infection 48.58 13.95 22 580029 19987 109989261
Forced expiratory volume decreased 48.45 13.95 6 580045 13170 109996078
Jaundice cholestatic 48.35 13.95 9 580042 14599 109994649
Ovarian neoplasm 48.27 13.95 34 580017 602 110008646
Exercise tolerance decreased 48.25 13.95 4 580047 12063 109997185
COVID-19 pneumonia 48.24 13.95 75 579976 37068 109972180
Acute hepatic failure 47.97 13.95 73 579978 36395 109972853
Heparin-induced thrombocytopenia 47.94 13.95 3 580048 11421 109997827
Back pain 47.91 13.95 1531 578520 369465 109639783
Lyme disease 47.48 13.95 83 579968 4233 110005015
Haematocrit decreased 47.48 13.95 182 579869 65935 109943313
Rhinorrhoea 47.43 13.95 329 579722 102337 109906911
Muscle spasticity 47.41 13.95 337 579714 35578 109973670
Hypertriglyceridaemia 47.37 13.95 13 580038 16141 109993107
Progressive multifocal leukoencephalopathy 47.16 13.95 37 580014 24919 109984329
Respiratory acidosis 46.89 13.95 8 580043 13818 109995430
Rhinovirus infection 46.89 13.95 4 580047 11785 109997463
Swollen joint count 46.84 13.95 125 579926 8549 110000699
Treatment noncompliance 46.76 13.95 210 579841 72780 109936468
Angina unstable 46.75 13.95 14 580037 16418 109992830
Central nervous system lesion 46.58 13.95 12 580039 15541 109993707
Cytomegalovirus infection reactivation 46.35 13.95 19 580032 18314 109990934
Anticipatory anxiety 46.14 13.95 44 580007 1212 110008036
Dactylitis 46.14 13.95 80 579971 4053 110005195
Retinal toxicity 46.13 13.95 50 580001 1609 110007639
Oral candidiasis 46.11 13.95 104 579947 44656 109964592
Product use in unapproved indication 46.07 13.95 1898 578153 445479 109563769
Diverticulitis 45.96 13.95 456 579595 53066 109956182
Drug dose omission by device 45.84 13.95 10 580041 14506 109994742
Pneumonitis 45.61 13.95 226 579825 76305 109932943
Gingival pain 45.51 13.95 13 580038 15723 109993525
Extremity contracture 45.38 13.95 51 580000 1710 110007538
Drug-induced liver injury 45.26 13.95 883 579168 119184 109890064
Glomerular filtration rate decreased 45.23 13.95 51 580000 28905 109980343
Epilepsy 45.18 13.95 758 579293 99451 109909797
Hiatus hernia 44.92 13.95 47 580004 27559 109981689
Bundle branch block left 44.73 13.95 7 580044 12881 109996367
Product quality issue 44.65 13.95 610 579441 76689 109932559
Pulse absent 44.45 13.95 4 580047 11288 109997960
Fatigue 44.34 13.95 7140 572911 1208818 108800430
Micturition urgency 44.23 13.95 23 580028 19297 109989951
Abnormal dreams 44.22 13.95 7 580044 12773 109996475
Hypovolaemic shock 44.16 13.95 11 580040 14572 109994676
Hyperuricaemia 43.93 13.95 11 580040 14520 109994728
Cytopenia 43.90 13.95 56 579995 30060 109979188
Drug level below therapeutic 43.70 13.95 5 580046 11668 109997580
Investigation abnormal 43.67 13.95 59 579992 2397 110006851
Extra dose administered 43.60 13.95 6 580045 12153 109997095
Metabolic encephalopathy 43.32 13.95 4 580047 11056 109998192
Oesophageal carcinoma 42.99 13.95 5 580046 11519 109997729
Pulseless electrical activity 42.97 13.95 17 580034 16740 109992508
Prostatic specific antigen increased 42.96 13.95 7 580044 12504 109996744
Arteriosclerosis 42.80 13.95 40 580011 24727 109984521
Throat irritation 42.73 13.95 141 579910 53411 109955837
Mood altered 42.57 13.95 30 580021 21345 109987903
Cold sweat 42.47 13.95 32 580019 21999 109987249
Pneumonia bacterial 42.41 13.95 45 580006 26216 109983032
Psychomotor hyperactivity 42.35 13.95 27 580024 20250 109988998
Cardiac murmur 42.29 13.95 40 580011 24588 109984660
Haemolytic anaemia 42.14 13.95 29 580022 20891 109988357
Hepatitis acute 42.00 13.95 23 580028 18743 109990505
Bradykinesia 41.99 13.95 4 580047 10784 109998464
Unevaluable event 41.91 13.95 164 579887 59063 109950185
Product administration interrupted 41.87 13.95 5 580046 11287 109997961
Apnoea 41.87 13.95 10 580041 13629 109995619
Bradyphrenia 41.55 13.95 6 580045 11722 109997526
Rebound effect 41.43 13.95 13 580038 14793 109994455
Staphylococcal infection 41.43 13.95 207 579844 69737 109939511
Hepatomegaly 41.42 13.95 31 580020 21383 109987865
Tuberculosis 41.40 13.95 194 579857 17580 109991668
Ketoacidosis 41.30 13.95 3 580048 10084 109999164
Potentiating drug interaction 41.15 13.95 6 580045 11637 109997611
Ulcer haemorrhage 41.15 13.95 230 579821 22341 109986907
Restless legs syndrome 41.12 13.95 41 580010 24585 109984663
Cerebral ischaemia 41.06 13.95 7 580044 12097 109997151
Peripheral sensory neuropathy 41.03 13.95 18 580033 16662 109992586
Feeling cold 41.00 13.95 72 579979 33915 109975333
Fracture delayed union 40.86 13.95 54 579997 2147 110007101
Hair follicle tumour benign 40.84 13.95 27 580024 429 110008819
Memory impairment 40.72 13.95 1336 578715 195608 109813640
Blood uric acid increased 40.58 13.95 32 580019 21497 109987751
Cystitis 40.52 13.95 193 579858 65843 109943405
Personality change 40.48 13.95 5 580046 10997 109998251
Emotional disorder 40.45 13.95 17 580034 16143 109993105
Lipase increased 40.19 13.95 24 580027 18648 109990600
Affect lability 40.05 13.95 24 580027 18613 109990635
Product prescribing issue 39.93 13.95 9 580042 12763 109996485
Hypopnoea 39.91 13.95 6 580045 11374 109997874
Transplant rejection 39.78 13.95 42 580009 24525 109984723
Bundle branch block right 39.78 13.95 8 580043 12283 109996965
Pustular psoriasis 39.75 13.95 159 579892 13446 109995802
Viral infection 39.64 13.95 144 579907 52995 109956253
Therapeutic response unexpected 39.47 13.95 40 580011 23803 109985445
Sneezing 39.27 13.95 67 579984 31917 109977331
Brain natriuretic peptide increased 39.10 13.95 6 580045 11203 109998045
Blood lactic acid increased 39.03 13.95 17 580034 15804 109993444
Hypercapnia 38.87 13.95 6 580045 11153 109998095
Hepatic cancer 38.85 13.95 6 580045 11150 109998098
Secretion discharge 38.72 13.95 209 579842 20035 109989213
Osteosclerosis 38.66 13.95 78 579973 4437 110004811
Pruritus allergic 38.65 13.95 46 580005 1642 110007606
Red cell distribution width decreased 38.58 13.95 53 579998 2188 110007060
Ageusia 38.56 13.95 28 580023 19617 109989631
Paralysis 38.11 13.95 17 580034 15583 109993665
Blood alkaline phosphatase increased 38.08 13.95 217 579834 70718 109938530
Drug resistance 38.06 13.95 159 579892 56215 109953033
Gastrointestinal procedural complication 37.97 13.95 26 580025 439 110008809
Diffuse large B-cell lymphoma 37.79 13.95 18 580033 15880 109993368
Lymphadenopathy 37.76 13.95 189 579862 63646 109945602
Enthesophyte 37.70 13.95 18 580033 145 110009103
Nervousness 37.65 13.95 86 579965 36765 109972483
Dermatitis acneiform 37.63 13.95 10 580041 12685 109996563
Clostridium test positive 37.62 13.95 6 580045 10887 109998361
Mass excision 37.60 13.95 24 580027 358 110008890
Hip fracture 37.59 13.95 80 579971 35071 109974177
Hepatocellular carcinoma 37.58 13.95 4 580047 9876 109999372
Pain of skin 37.46 13.95 30 580021 19999 109989249
Skin haemorrhage 37.41 13.95 45 580006 24782 109984466
Head discomfort 37.40 13.95 27 580024 18973 109990275
Cardiac tamponade 37.35 13.95 7 580044 11300 109997948
Congestive cardiomyopathy 37.16 13.95 14 580037 14205 109995043
Gastroenteritis 36.91 13.95 94 579957 38706 109970542
Nail operation 36.89 13.95 45 580006 1649 110007599
Vasculitic rash 36.80 13.95 52 579999 2205 110007043
Premature labour 36.79 13.95 3 580048 9169 110000079
Breast cancer metastatic 36.77 13.95 7 580044 11174 109998074
Haemolysis 36.73 13.95 18 580033 15621 109993627
Electrocardiogram ST segment elevation 36.73 13.95 3 580048 9157 110000091
Concomitant disease aggravated 36.70 13.95 20 580031 16344 109992904
Amnesia 36.67 13.95 766 579285 104642 109904606
Staphylococcal bacteraemia 36.56 13.95 21 580030 16667 109992581
Skin irritation 36.52 13.95 20 580031 16299 109992949
Wrist surgery 36.50 13.95 33 580018 848 110008400
Loss of employment 36.38 13.95 64 579987 3280 110005968
Cerebral haematoma 36.38 13.95 4 580047 9628 109999620
Large intestine perforation 36.32 13.95 21 580030 16608 109992640
Hypocholesterolaemia 36.17 13.95 94 579957 6327 110002921
Azotaemia 36.10 13.95 5 580046 10080 109999168
Bronchitis chronic 36.10 13.95 80 579971 4860 110004388
Urosepsis 36.09 13.95 66 579985 30609 109978639
Rib fracture 35.99 13.95 77 579974 33693 109975555
Intestinal perforation 35.98 13.95 34 580017 20910 109988338
Peritonitis bacterial 35.93 13.95 6 580045 10527 109998721
Cholecystitis acute 35.82 13.95 19 580032 15763 109993485
Decubitus ulcer 35.79 13.95 26 580025 18210 109991038
Soft tissue swelling 35.74 13.95 45 580006 1704 110007544
Therapy change 35.69 13.95 5 580046 9992 109999256
Left ventricular failure 35.66 13.95 8 580043 11381 109997867
Joint ankylosis 35.60 13.95 54 579997 2443 110006805
Increased appetite 35.54 13.95 17 580034 14960 109994288
Blood pressure systolic decreased 35.52 13.95 13 580038 13428 109995820
Cardiac failure chronic 35.43 13.95 14 580037 13797 109995451
Bacterial sepsis 35.43 13.95 6 580045 10420 109998828
Pain in jaw 35.39 13.95 143 579908 51034 109958214
Drug effective for unapproved indication 35.31 13.95 15 580036 14152 109995096
Eyelid oedema 35.19 13.95 18 580033 15244 109994004
Polyneuropathy 34.95 13.95 72 579979 31940 109977308
Gastric haemorrhage 34.90 13.95 20 580031 15895 109993353
Sputum discoloured 34.81 13.95 58 579993 27887 109981361
Cytology abnormal 34.71 13.95 22 580029 324 110008924
Eosinophilic granulomatosis with polyangiitis 34.49 13.95 7 580044 10679 109998569
Localised oedema 34.41 13.95 4 580047 9219 110000029
Throat tightness 34.34 13.95 78 579973 33411 109975837
Facial paralysis 34.29 13.95 46 580005 24168 109985080
Arterial occlusive disease 33.91 13.95 19 580032 15289 109993959
Aortic stenosis 33.90 13.95 13 580038 13046 109996202
Blood albumin decreased 33.88 13.95 58 579993 27594 109981654
Ventricular arrhythmia 33.85 13.95 6 580045 10081 109999167
Cerebral atrophy 33.74 13.95 4 580047 9081 110000167
Aplasia pure red cell 33.70 13.95 5 580046 9573 109999675
Vascular access complication 33.70 13.95 53 579998 2475 110006773
Metabolic disorder 33.68 13.95 7 580044 10503 109998745
Lung infiltration 33.66 13.95 48 580003 24580 109984668
Infiltration anaesthesia 33.63 13.95 17 580034 157 110009091
Pneumatosis intestinalis 33.63 13.95 3 580048 8526 110000722
Eyelid ptosis 33.39 13.95 14 580037 13313 109995935
Steroid dependence 33.34 13.95 3 580048 8466 110000782
Cholecystitis chronic 33.33 13.95 5 580046 9495 109999753
Blood triglycerides increased 33.33 13.95 46 580005 23880 109985368
Immunosuppressant drug level increased 33.33 13.95 10 580041 11714 109997534
Leukopenia 33.29 13.95 564 579487 148227 109861021
Squamous cell carcinoma of skin 33.15 13.95 25 580026 17178 109992070
Erythema multiforme 33.13 13.95 37 580014 21060 109988188
Red blood cell count decreased 33.10 13.95 206 579845 65717 109943531
Mixed liver injury 33.10 13.95 11 580040 12068 109997180
Hydrocephalus 33.06 13.95 7 580044 10368 109998880
Hypertonia 33.03 13.95 3 580048 8403 110000845
Colon cancer 32.85 13.95 23 580028 16420 109992828
Drug level above therapeutic 32.74 13.95 10 580041 11578 109997670
Foetal death 32.65 13.95 22 580029 16023 109993225
Gastrointestinal pain 32.59 13.95 136 579915 11724 109997524
Carotid artery stenosis 32.22 13.95 5 580046 9258 109999990
Haemorrhagic stroke 32.19 13.95 16 580035 13773 109995475
Insurance issue 32.14 13.95 8 580043 10604 109998644
Abnormal faeces 32.09 13.95 5 580046 9231 110000017
Respiratory syncytial virus infection 32.05 13.95 18 580033 14466 109994782
Adenovirus infection 31.95 13.95 9 580042 10985 109998263
Mean platelet volume decreased 31.90 13.95 60 579991 3240 110006008
Aortic valve incompetence 31.89 13.95 9 580042 10972 109998276
Methaemoglobinaemia 31.77 13.95 5 580046 9163 110000085
Large intestine polyp 31.75 13.95 20 580031 15097 109994151
Amylase increased 31.61 13.95 13 580038 12506 109996742
Coronary artery occlusion 31.59 13.95 22 580029 15750 109993498
Left ventricular hypertrophy 31.48 13.95 15 580036 13229 109996019
Hyperpyrexia 31.38 13.95 3 580048 8066 110001182
Petechiae 31.32 13.95 46 580005 23271 109985977
Duodenal ulcer haemorrhage 31.23 13.95 3 580048 8034 110001214
Product administered to patient of inappropriate age 31.22 13.95 3 580048 8033 110001215
Pseudomonal sepsis 31.20 13.95 5 580046 9041 110000207
Refusal of treatment by patient 31.10 13.95 6 580045 9488 109999760
Motor dysfunction 31.01 13.95 50 580001 24356 109984892
Nystagmus 30.93 13.95 11 580040 11566 109997682
Spinal fusion surgery 30.87 13.95 112 579939 9044 110000204
Blood culture positive 30.87 13.95 5 580046 8971 110000277
Graft versus host disease in gastrointestinal tract 30.83 13.95 5 580046 8963 110000285
Caesarean section 30.82 13.95 17 580034 13800 109995448
Post procedural complication 30.79 13.95 58 579993 26600 109982648
Muscle tightness 30.36 13.95 20 580031 14742 109994506
Brain herniation 30.34 13.95 5 580046 8858 110000390
Radiculopathy 30.26 13.95 34 580017 19302 109989946
Granuloma 30.25 13.95 114 579937 9376 109999872
Grip strength 30.13 13.95 111 579940 9030 110000218
Polyomavirus-associated nephropathy 29.96 13.95 103 579948 8098 110001150
Hypoacusis 29.94 13.95 90 579961 35101 109974147
Dry throat 29.92 13.95 6 580045 9232 110000016
Pulmonary thrombosis 29.90 13.95 148 579903 13715 109995533
Amenorrhoea 29.89 13.95 6 580045 9225 110000023
Metastasis 29.83 13.95 4 580047 8263 110000985
Embolic stroke 29.78 13.95 5 580046 8738 110000510
Body temperature increased 29.68 13.95 427 579624 54286 109954962
Tension headache 29.62 13.95 7 580044 9611 109999637
Sinus congestion 29.59 13.95 73 579978 30386 109978862
Pulmonary function test decreased 29.58 13.95 5 580046 8695 110000553
Bowel movement irregularity 29.40 13.95 3 580048 7657 110001591
Skin burning sensation 29.38 13.95 43 580008 21782 109987466
Hypermobility syndrome 29.35 13.95 24 580027 536 110008712
Device occlusion 29.35 13.95 22 580029 15163 109994085
Arteriospasm coronary 29.29 13.95 6 580045 9094 110000154
Labile blood pressure 29.13 13.95 49 580002 2422 110006826
Scratch 28.91 13.95 16 580035 12963 109996285
Supraventricular extrasystoles 28.91 13.95 4 580047 8069 110001179
Allergic oedema 28.89 13.95 30 580021 918 110008330
Haemophagocytic lymphohistiocytosis 28.85 13.95 78 579973 31481 109977767
Petit mal epilepsy 28.85 13.95 3 580048 7544 110001704
Flank pain 28.82 13.95 48 580003 23082 109986166
Paronychia 28.81 13.95 11 580040 11070 109998178
Hypoaesthesia oral 28.75 13.95 28 580023 16974 109992274
Multiple sclerosis 28.74 13.95 57 579994 25641 109983607
Femoral neck fracture 28.71 13.95 15 580036 12552 109996696
Pulmonary congestion 28.71 13.95 76 579975 30890 109978358
Multiple drug therapy 28.63 13.95 4 580047 8010 110001238
Hyperventilation 28.59 13.95 6 580045 8941 110000307
Dermatitis contact 28.57 13.95 19 580032 13934 109995314
Product monitoring error 28.50 13.95 6 580045 8921 110000327
Renal cyst 28.39 13.95 32 580019 18140 109991108
Dermatitis bullous 28.35 13.95 30 580021 17499 109991749
Rash morbilliform 28.33 13.95 4 580047 7947 110001301
Poor quality sleep 28.30 13.95 66 579985 28011 109981237
Renal tubular disorder 28.28 13.95 3 580048 7426 110001822
Heart rate irregular 28.21 13.95 89 579962 34185 109975063
Complication of device insertion 28.09 13.95 6 580045 8832 110000416
Infusion site extravasation 27.92 13.95 13 580038 11621 109997627
Hypovolaemia 27.92 13.95 44 580007 21630 109987618
Localised infection 27.92 13.95 347 579704 42701 109966547
Gastritis erosive 27.90 13.95 14 580037 11986 109997262
Transaminases abnormal 27.86 13.95 30 580021 958 110008290
Haemarthrosis 27.79 13.95 3 580048 7326 110001922
Systemic inflammatory response syndrome 27.74 13.95 17 580034 13026 109996222
Blood thyroid stimulating hormone increased 27.64 13.95 15 580036 12286 109996962
White blood cell count increased 27.61 13.95 350 579701 96492 109912756
Cachexia 27.60 13.95 17 580034 12988 109996260
Tongue oedema 27.51 13.95 5 580046 8251 110000997
Oesophageal candidiasis 27.51 13.95 13 580038 11521 109997727
Disease recurrence 27.48 13.95 196 579855 60588 109948660
Facial pain 27.43 13.95 24 580027 15315 109993933
Demyelination 27.39 13.95 110 579941 9319 109999929
Bunion operation 27.26 13.95 29 580022 913 110008335
Pre-eclampsia 27.23 13.95 6 580045 8644 110000604
Retinal haemorrhage 27.20 13.95 8 580043 9493 109999755
Dizziness postural 27.18 13.95 22 580029 14587 109994661
Blood phosphorus decreased 26.97 13.95 4 580047 7661 110001587
Osteoporotic fracture 26.91 13.95 75 579976 5262 110003986
Drooling 26.87 13.95 3 580048 7136 110002112
Oedema 26.84 13.95 1353 578698 208623 109800625
Splenomegaly 26.83 13.95 55 579996 24443 109984805
Haemorrhoidal haemorrhage 26.76 13.95 5 580046 8088 110001160
Thinking abnormal 26.70 13.95 24 580027 15116 109994132
Mean cell volume decreased 26.68 13.95 78 579973 5624 110003624
Injection site hypersensitivity 26.51 13.95 47 580004 2424 110006824
Spinal cord compression 26.44 13.95 4 580047 7548 110001700
Normochromic normocytic anaemia 26.44 13.95 18 580033 13039 109996209
Anal fistula 26.43 13.95 6 580045 8467 110000781
Skin papilloma 26.41 13.95 88 579963 6808 110002440
Eye movement disorder 26.41 13.95 9 580042 9719 109999529
Injection site mass 26.33 13.95 56 579995 24557 109984691
Mouth ulceration 26.23 13.95 376 579675 47762 109961486
Nail psoriasis 26.21 13.95 25 580026 689 110008559
Ventricular hypokinesia 26.20 13.95 13 580038 11201 109998047
Macular oedema 26.04 13.95 3 580048 6963 110002285
Anger 26.02 13.95 37 580014 18970 109990278
Optic neuritis 25.92 13.95 13 580038 11134 109998114
Fear of injection 25.92 13.95 104 579947 8807 110000441
Leukoencephalopathy 25.86 13.95 8 580043 9187 110000061
Upper-airway cough syndrome 25.80 13.95 27 580024 15830 109993418
Extrasystoles 25.73 13.95 6 580045 8312 110000936
Hypogammaglobulinaemia 25.63 13.95 41 580010 20035 109989213
Vitreous floaters 25.59 13.95 8 580043 9126 110000122
Hyperlactacidaemia 25.58 13.95 6 580045 8280 110000968
Hepatic necrosis 25.55 13.95 10 580041 9912 109999336
Ammonia increased 25.42 13.95 6 580045 8244 110001004
Tender joint count 25.32 13.95 34 580017 1373 110007875
Sinus node dysfunction 25.21 13.95 8 580043 9039 110000209
Spondylitis 25.14 13.95 122 579929 11216 109998032
Liver abscess 25.12 13.95 5 580046 7734 110001514
Cardiovascular disorder 25.01 13.95 51 580000 22709 109986539
Joint lock 24.99 13.95 57 579994 3531 110005717
Hepatic function abnormal 24.99 13.95 324 579727 88971 109920277
Duodenal ulcer 24.77 13.95 40 580011 19474 109989774
Sexual dysfunction 24.76 13.95 7 580044 8523 110000725
Injection site swelling 24.76 13.95 206 579845 61584 109947664
Device related sepsis 24.70 13.95 5 580046 7642 110001606
Spinal stenosis 24.68 13.95 178 579873 18878 109990370
Middle lobe syndrome 24.61 13.95 9 580042 33 110009215
Blood glucose abnormal 24.59 13.95 19 580032 12897 109996351
Hepatitis C 24.58 13.95 18 580033 12555 109996693
Peripheral arterial occlusive disease 24.48 13.95 9 580042 9271 109999977
Gastrointestinal necrosis 24.47 13.95 3 580048 6637 110002611
Initial insomnia 24.34 13.95 12 580039 10377 109998871
Needle issue 24.16 13.95 35 580016 17805 109991443
Ventricular hypertrophy 24.06 13.95 4 580047 7041 110002207
Carotid artery occlusion 24.04 13.95 10 580041 9555 109999693
Metastases to lymph nodes 24.00 13.95 26 580025 15006 109994242
Incoherent 24.00 13.95 7 580044 8351 110000897
Blood immunoglobulin E increased 23.94 13.95 5 580046 7477 110001771
Hyperammonaemia 23.94 13.95 22 580029 13710 109995538
Hydronephrosis 23.84 13.95 45 580006 20620 109988628
Expired product administered 23.83 13.95 7 580044 8313 110000935
Major depression 23.79 13.95 13 580038 10608 109998640
Lung neoplasm malignant 23.76 13.95 94 579957 33748 109975500
Fibrin D dimer increased 23.63 13.95 11 580040 9834 109999414
Aortic arteriosclerosis 23.63 13.95 14 580037 10924 109998324
Gestational diabetes 23.52 13.95 5 580046 7384 110001864
Back disorder 23.49 13.95 189 579862 20733 109988515
Pancreatitis 23.45 13.95 347 579704 93186 109916062
Pancreatic carcinoma 23.44 13.95 26 580025 14846 109994402
Eye irritation 23.43 13.95 93 579958 33359 109975889
Urine analysis abnormal 23.37 13.95 4 580047 6893 110002355
Multiple-drug resistance 23.31 13.95 21 580030 13214 109996034
Herpes simplex 23.30 13.95 29 580022 15735 109993513
Pseudomembranous colitis 23.28 13.95 3 580048 6388 110002860
Concussion 23.23 13.95 16 580035 11522 109997726
Tendon disorder 23.22 13.95 96 579955 8241 110001007
Abdominal distension 23.21 13.95 720 579331 174383 109834865
Hepatitis fulminant 23.10 13.95 8 580043 8552 110000696
Disease susceptibility 23.07 13.95 17 580034 324 110008924
Anosmia 22.93 13.95 19 580032 12453 109996795
Heart rate decreased 22.89 13.95 301 579750 82455 109926793
Snoring 22.84 13.95 4 580047 6780 110002468
Hepatotoxicity 22.79 13.95 463 579588 62937 109946311
Pyelonephritis acute 22.72 13.95 5 580046 7208 110002040
Systemic candida 22.65 13.95 12 580039 9962 109999286
Respiratory rate decreased 22.65 13.95 3 580048 6255 110002993
Peripheral coldness 22.61 13.95 39 580012 18501 109990747
Dermatitis exfoliative 22.50 13.95 16 580035 11331 109997917
Depressive symptom 22.47 13.95 8 580043 8406 110000842
Kidney transplant rejection 22.36 13.95 18 580033 11969 109997279
Hereditary angioedema 22.27 13.95 5 580046 7109 110002139
Pneumocystis jirovecii pneumonia 22.26 13.95 132 579919 42603 109966645
Defaecation urgency 22.22 13.95 9 580042 8738 110000510
SARS-CoV-2 test positive 22.18 13.95 34 580017 16901 109992347
Non-small cell lung cancer 22.14 13.95 7 580044 7928 110001320
Ear discomfort 22.12 13.95 16 580035 11233 109998015
Ventricular dysfunction 22.11 13.95 6 580045 7505 110001743
Transaminases increased 22.06 13.95 219 579832 63171 109946077
Ischaemia 22.03 13.95 10 580041 9073 110000175
Portal vein thrombosis 22.01 13.95 5 580046 7053 110002195
Respiration abnormal 21.98 13.95 12 580039 9797 109999451
Escherichia bacteraemia 21.97 13.95 13 580038 10151 109999097
Rhinitis 21.93 13.95 54 579997 22491 109986757
Rash pustular 21.84 13.95 21 580030 12808 109996440
Fistula 21.73 13.95 29 580022 15270 109993978
Injection site erythema 21.71 13.95 355 579696 93821 109915427
Eosinophil count decreased 21.51 13.95 3 580048 6015 110003233
Subileus 21.23 13.95 4 580047 6433 110002815
Overwork 21.21 13.95 9 580042 53 110009195
Dermatitis exfoliative generalised 21.07 13.95 16 580035 10956 109998292
Type I hypersensitivity 21.03 13.95 4 580047 6389 110002859
Performance status decreased 21.02 13.95 6 580045 7260 110001988
Undifferentiated connective tissue disease 20.88 13.95 14 580037 228 110009020
Eating disorder 20.85 13.95 87 579964 30771 109978477
Meningitis aseptic 20.81 13.95 13 580038 9857 109999391
Gastric ulcer 20.76 13.95 123 579928 39704 109969544
Faeces soft 20.70 13.95 17 580034 11193 109998055
Catheter site infection 20.70 13.95 8 580043 7992 110001256
Lip oedema 20.69 13.95 7 580044 7593 110001655
Glucose tolerance impaired 20.68 13.95 13 580038 9824 109999424
Bacterial test positive 20.61 13.95 8 580043 7969 110001279
Sluggishness 20.54 13.95 7 580044 7560 110001688
Rales 20.53 13.95 64 579987 24675 109984573
Normal newborn 20.50 13.95 190 579861 21706 109987542
Cell death 20.43 13.95 3 580048 5788 110003460
Intentional dose omission 20.40 13.95 47 580004 20033 109989215
Total lung capacity decreased 20.35 13.95 6 580045 7108 110002140
Thrombotic thrombocytopenic purpura 20.34 13.95 6 580045 7105 110002143
Cardiopulmonary failure 20.29 13.95 8 580043 7895 110001353
Self-medication 20.29 13.95 4 580047 6228 110003020
Soft tissue disorder 20.27 13.95 52 579999 3472 110005776
Product availability issue 20.24 13.95 8 580043 7882 110001366
Bipolar disorder 20.21 13.95 11 580040 8996 110000252
Photopsia 20.20 13.95 4 580047 6210 110003038
Portal hypertension 20.20 13.95 10 580041 8627 110000621
Tachyarrhythmia 20.19 13.95 9 580042 8252 110000996
High density lipoprotein decreased 20.16 13.95 3 580048 5730 110003518
Peripheral ischaemia 20.14 13.95 17 580034 11041 109998207
Conjunctival haemorrhage 20.09 13.95 5 580046 6628 110002620
Pneumonia klebsiella 20.09 13.95 5 580046 6627 110002621
Orthopnoea 20.00 13.95 17 580034 11004 109998244
Injection site haemorrhage 19.99 13.95 97 579954 32931 109976317
Muscle relaxant therapy 19.96 13.95 12 580039 160 110009088
Gastric cancer 19.95 13.95 17 580034 10991 109998257
Oxygen consumption increased 19.93 13.95 3 580048 5682 110003566
Neuritis 19.82 13.95 7 580044 7392 110001856
Escherichia urinary tract infection 19.71 13.95 34 580017 16128 109993120
Sudden cardiac death 19.70 13.95 3 580048 5634 110003614
Musculoskeletal chest pain 19.70 13.95 81 579970 28766 109980482
Hypertensive crisis 19.56 13.95 64 579987 24308 109984940
Intermenstrual bleeding 19.56 13.95 6 580045 6928 110002320
Spinal compression fracture 19.55 13.95 42 580009 18350 109990898
Cutaneous B-cell lymphoma 19.51 13.95 11 580040 129 110009119
Spinal meningioma benign 19.45 13.95 10 580041 96 110009152
Breast cancer female 19.43 13.95 22 580029 12446 109996802
Non-cardiac chest pain 19.42 13.95 15 580036 10183 109999065
Periorbital oedema 19.40 13.95 15 580036 10177 109999071
Stridor 19.39 13.95 6 580045 6889 110002359
Thrombophlebitis 19.35 13.95 8 580043 7671 110001577
Autoimmune thyroiditis 19.20 13.95 5 580046 6429 110002819
Latent tuberculosis 19.18 13.95 55 579996 3922 110005326
Rheumatoid factor 19.18 13.95 19 580032 549 110008699
Blood sodium increased 19.17 13.95 3 580048 5520 110003728
Choking 19.16 13.95 31 580020 15079 109994169
Ischaemic cardiomyopathy 19.15 13.95 9 580042 8002 110001246
Urine abnormality 19.15 13.95 12 580039 9084 110000164
Heart rate abnormal 19.13 13.95 7 580044 7231 110002017
Spirometry abnormal 19.04 13.95 3 580048 5494 110003754
Varices oesophageal 19.03 13.95 7 580044 7208 110002040
Muscle spasms 18.95 13.95 1700 578351 276457 109732791
Internal haemorrhage 18.94 13.95 15 580036 10056 109999192
Nephrotic syndrome 18.86 13.95 27 580024 13804 109995444
Foot fracture 18.81 13.95 211 579840 25335 109983913
Lung opacity 18.78 13.95 20 580031 11632 109997616
Hepatic fibrosis 18.76 13.95 88 579963 7978 110001270
Mean cell haemoglobin decreased 18.73 13.95 81 579970 7093 110002155
Leukaemia 18.67 13.95 8 580043 7510 110001738
Spinal fracture 18.47 13.95 59 579992 22574 109986674
Knee deformity 18.43 13.95 31 580020 1532 110007716
Disease complication 18.43 13.95 4 580047 5823 110003425
Skin fissures 18.43 13.95 66 579985 24392 109984856
Endophthalmitis 18.37 13.95 10 580041 8177 110001071
Necrobiosis 18.36 13.95 5 580046 4 110009244
Serum ferritin increased 18.36 13.95 21 580030 11826 109997422
Jugular vein thrombosis 18.33 13.95 3 580048 5342 110003906
Ocular discomfort 18.32 13.95 11 580040 8522 110000726
Pulmonary toxicity 18.16 13.95 157 579894 17589 109991659
Breast cancer stage I 18.13 13.95 8 580043 7379 110001869
Hepatic enzyme 18.13 13.95 64 579987 5099 110004149
Post-traumatic stress disorder 18.09 13.95 6 580045 6590 110002658
Gamma-glutamyltransferase increased 18.07 13.95 220 579831 61089 109948159
Respiratory rate increased 18.04 13.95 69 579982 25014 109984234
Tender joint count increased 17.99 13.95 16 580035 402 110008846
Synovial disorder 17.95 13.95 45 580006 2962 110006286
Humerus fracture 17.93 13.95 18 580033 10758 109998490
Nephritis 17.83 13.95 5 580046 6121 110003127
Elbow operation 17.75 13.95 17 580034 471 110008777
Visual field defect 17.72 13.95 16 580035 10056 109999192
Smear cervix abnormal 17.70 13.95 42 580009 2670 110006578
Formication 17.62 13.95 4 580047 5644 110003604
Mean cell haemoglobin concentration abnormal 17.61 13.95 12 580039 201 110009047
Blood thyroid stimulating hormone decreased 17.51 13.95 8 580043 7231 110002017
Tooth disorder 17.50 13.95 234 579817 29275 109979973
Oesophageal stenosis 17.49 13.95 3 580048 5162 110004086
Juvenile idiopathic arthritis 17.39 13.95 70 579981 5937 110003311
Polyp 17.38 13.95 16 580035 9964 109999284
Escherichia sepsis 17.27 13.95 17 580034 10255 109998993
Ovarian cyst 17.27 13.95 29 580022 13901 109995347
Pneumonia pseudomonal 17.25 13.95 9 580042 7537 110001711
Blood urine present 17.24 13.95 67 579984 24178 109985070
Renal cancer 17.23 13.95 26 580025 13008 109996240
Clonal haematopoiesis 17.18 13.95 11 580040 165 110009083
Areflexia 17.14 13.95 7 580044 6762 110002486
Tension 17.08 13.95 3 580048 5075 110004173
Streptococcal sepsis 17.06 13.95 3 580048 5069 110004179
Wrist fracture 16.98 13.95 31 580020 14386 109994862
Brain neoplasm 16.97 13.95 6 580045 6331 110002917
Faecal calprotectin increased 16.93 13.95 7 580044 6712 110002536
Diabetic eye disease 16.92 13.95 12 580039 215 110009033
Heavy menstrual bleeding 16.87 13.95 38 580013 16327 109992921
Complications of transplanted kidney 16.83 13.95 9 580042 7433 110001815
Embolism venous 16.83 13.95 3 580048 5020 110004228
Product storage error 16.79 13.95 58 579993 21670 109987578
Candida infection 16.65 13.95 166 579885 47843 109961405
Impaired gastric emptying 16.62 13.95 123 579928 13152 109996096
Umbilical hernia 16.62 13.95 8 580043 7014 110002234
Tenosynovitis stenosans 16.58 13.95 49 580002 3554 110005694
Wheelchair user 16.40 13.95 83 579968 7759 110001489
Diarrhoea haemorrhagic 16.38 13.95 36 580015 15603 109993645
Neutrophilia 16.34 13.95 18 580033 10311 109998937
Catheterisation cardiac 16.34 13.95 6 580045 6185 110003063
Oropharyngeal discomfort 16.34 13.95 18 580033 10309 109998939
Decreased interest 16.30 13.95 3 580048 4905 110004343
Pyopneumothorax 16.29 13.95 8 580043 69 110009179
Neck mass 16.28 13.95 59 579992 4762 110004486
Sensation of foreign body 16.14 13.95 11 580040 7964 110001284
Skin infection 16.13 13.95 62 579989 22447 109986801
Protein total decreased 16.13 13.95 20 580031 10870 109998378
Papulopustular rosacea 16.12 13.95 7 580044 44 110009204
Klebsiella bacteraemia 16.11 13.95 3 580048 4866 110004382
Allergy to chemicals 16.06 13.95 46 580005 3279 110005969
Odynophagia 16.01 13.95 31 580020 14070 109995178
Subcutaneous drug absorption impaired 15.98 13.95 81 579970 7578 110001670
Upper respiratory tract infection 15.97 13.95 546 579505 130782 109878466
Bronchitis 15.96 13.95 667 579384 156365 109852883
Blood pressure abnormal 15.92 13.95 62 579989 22362 109986886
Blood lactate dehydrogenase increased 15.92 13.95 152 579899 44182 109965066
Anal fissure 15.88 13.95 17 580034 9864 109999384
Fungal infection 15.87 13.95 180 579871 50626 109958622
Steatohepatitis 15.84 13.95 26 580025 1259 110007989
Anaphylactoid reaction 15.82 13.95 8 580043 6818 110002430
Meningitis 15.80 13.95 23 580028 11679 109997569
Neoplasm 15.76 13.95 21 580030 11066 109998182
Conjunctivitis 15.75 13.95 108 579943 33684 109975564
Rheumatic disorder 15.74 13.95 48 580003 3543 110005705
Aphonia 15.73 13.95 27 580024 12833 109996415
Menstrual disorder 15.72 13.95 3 580048 4781 110004467
Weber tuning fork test abnormal 15.64 13.95 9 580042 110 110009138
Diverticulum intestinal haemorrhagic 15.62 13.95 3 580048 4760 110004488
Laryngeal oedema 15.62 13.95 17 580034 9790 109999458
Intestinal ischaemia 15.54 13.95 39 580012 16140 109993108
Intervertebral disc degeneration 15.49 13.95 154 579897 17931 109991317
Impaired driving ability 15.47 13.95 7 580044 6363 110002885
Vitamin B12 deficiency 15.39 13.95 18 580033 10037 109999211
Haemorrhage subcutaneous 15.26 13.95 5 580046 5534 110003714
Streptococcal bacteraemia 15.19 13.95 3 580048 4666 110004582
Blood pH decreased 15.19 13.95 3 580048 4666 110004582
Cardiac pacemaker insertion 15.19 13.95 7 580044 6294 110002954
Neck surgery 15.15 13.95 34 580017 2083 110007165
Staphylococcus test positive 15.14 13.95 10 580041 7360 110001888
Iron deficiency anaemia 15.14 13.95 100 579951 31459 109977789
Incorrect drug administration rate 15.12 13.95 5 580046 5503 110003745
Sebaceous gland infection 15.12 13.95 10 580041 159 110009089
Platelet count abnormal 15.11 13.95 7 580044 6275 110002973
Vasculitis 15.10 13.95 118 579933 35755 109973493
Poor quality product administered 15.06 13.95 3 580048 4638 110004610
Anticoagulation drug level above therapeutic 15.01 13.95 3 580048 4627 110004621
Hepatic ischaemia 15.00 13.95 25 580026 1226 110008022
Butterfly rash 15.00 13.95 34 580017 2097 110007151
Multiple allergies 15.00 13.95 113 579938 12150 109997098
Tumour marker increased 14.97 13.95 4 580047 5056 110004192
Stenotrophomonas infection 14.93 13.95 6 580045 5852 110003396
Hypercalcaemia 14.92 13.95 335 579716 46322 109962926
Sarcoidosis 14.88 13.95 115 579936 12464 109996784
Photophobia 14.84 13.95 77 579974 25694 109983554
Renal function test abnormal 14.82 13.95 15 580036 8931 110000317
Total lung capacity abnormal 14.80 13.95 3 580048 4580 110004668
Asthma 14.78 13.95 1121 578930 249170 109760078
Procedural haemorrhage 14.77 13.95 5 580046 5422 110003826
Infusion site pruritus 14.74 13.95 4 580047 5004 110004244
Lung consolidation 14.74 13.95 20 580031 10456 109998792
Enterobacter infection 14.73 13.95 6 580045 5805 110003443
Oral mucosal blistering 14.69 13.95 12 580039 7922 110001326
Upper limb fracture 14.67 13.95 58 579993 20830 109988418
Blood bicarbonate decreased 14.67 13.95 6 580045 5791 110003457
Pleuritic pain 14.67 13.95 40 580011 16100 109993148
Blepharitis 14.65 13.95 3 580048 4549 110004699
Haemolytic uraemic syndrome 14.64 13.95 4 580047 4981 110004267
Ossicle disorder 14.63 13.95 6 580045 32 110009216
Presbyacusis 14.60 13.95 40 580011 2779 110006469
Duodenitis 14.58 13.95 16 580035 9180 110000068
Facial bones fracture 14.58 13.95 4 580047 4967 110004281
Carpal tunnel syndrome 14.55 13.95 182 579869 22428 109986820
Blood disorder 14.55 13.95 18 580033 9792 109999456
Acute lymphocytic leukaemia 14.53 13.95 6 580045 5759 110003489
Rhonchi 14.50 13.95 3 580048 4515 110004733
Listless 14.48 13.95 3 580048 4512 110004736
Gastric ulcer haemorrhage 14.47 13.95 19 580032 10075 109999173
Dysaesthesia 14.46 13.95 9 580042 6838 110002410
Venous thrombosis 14.39 13.95 14 580037 8491 110000757
Overlap syndrome 14.37 13.95 89 579962 8970 110000278
Incorrect dose administered by device 14.33 13.95 9 580042 6805 110002443
Retroperitonitis 14.27 13.95 4 580047 4 110009244
Intervertebral disc compression 14.26 13.95 26 580025 1371 110007877
Limb operation 14.23 13.95 50 580001 3974 110005274
Hypertonic bladder 14.23 13.95 5 580046 5297 110003951
CD4/CD8 ratio increased 14.19 13.95 5 580046 16 110009232
Device breakage 14.17 13.95 32 580019 13737 109995511
Adrenocortical insufficiency acute 14.14 13.95 3 580048 4437 110004811
Streptococcal infection 14.13 13.95 22 580029 10868 109998380
Meningioma 14.12 13.95 6 580045 5659 110003589
Occult blood positive 14.11 13.95 11 580040 7434 110001814
Food intolerance 14.11 13.95 54 579997 4473 110004775
Cartilage atrophy 14.10 13.95 10 580041 179 110009069
Osteogenesis imperfecta 14.10 13.95 19 580032 770 110008478
Nerve block 14.10 13.95 19 580032 770 110008478
Haemoglobin abnormal 14.03 13.95 16 580035 9022 110000226
Paresis 14.01 13.95 4 580047 4840 110004408
Tendinous contracture 13.99 13.95 12 580039 287 110008961
Autoimmune hepatitis 13.98 13.95 36 580015 14768 109994480

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AK01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Dihydroorotate dehydrogenase (DHODH) inhibitors
MeSH PA D000700 Analgesics
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018689 Sensory System Agents
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D004791 Enzyme Inhibitors
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35442 antiparasitic agent
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:37153 EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor
CHEBI has role CHEBI:38637 tyrosine kinase inhibitor
CHEBI has role CHEBI:50266 prodrug
CHEBI has role CHEBI:50908 hepatotoxic agent
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:68542 EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitor
CHEBI has role CHEBI:68543 pyrimidine synthesis inhibitor
FDA EPC N0000175713 Antirheumatic Agent
FDA MoA N0000185501 Dihydroorotate Dehydrogenase Inhibitors
FDA EPC N0000185502 Pyrimidine Synthesis Inhibitor
CHEBI has role CHEBI:49103 drug metabolite
CHEBI has role CHEBI:231911 renoprotective agent

Related Drugs by ATC class:

L04AK Dihydroorotate dehydrogenase (DHODH) inhibitors 1 drug
teriflunomide

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Psoriasis with arthropathy indication 33339001
Rheumatoid arthritis indication 69896004 DOID:7148
Inactive tuberculosis contraindication 11999007
Agranulocytosis contraindication 17182001 DOID:12987
Acute tuberculosis contraindication 25629007
Immunosuppression contraindication 38013005
Hepatic failure contraindication 59927004
Chronic type B viral hepatitis contraindication 61977001
Acute infectious disease contraindication 63171007
Interstitial pneumonia contraindication 64667001
Aspergillosis contraindication 65553006 DOID:13564
Viral hepatitis type B contraindication 66071002 DOID:2043
Kidney disease contraindication 90708001 DOID:557
Pancytopenia contraindication 127034005 DOID:12450
Chronic hepatitis C contraindication 128302006
Liver function tests abnormal contraindication 166603001
Disease of liver contraindication 235856003 DOID:409
Acute hepatitis C contraindication 235866006
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Peripheral nerve disease contraindication 302226006
Neutropenic disorder contraindication 303011007 DOID:1227
Breastfeeding (mother) contraindication 413712001
Pneumocystosis jiroveci pneumonia contraindication 415125002 DOID:11339
Severe Bone Marrow Depression contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.31 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Dihydroorotate dehydrogenase (quinone), mitochondrial Enzyme INHIBITOR IC50 5 CHEMBL CHEMBL
Sodium-dependent noradrenaline transporter Transporter Ki 5.34 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 5.64 DRUG MATRIX
Cytochrome P450 1A2 Enzyme IC50 6.30 DRUG MATRIX
Amine oxidase [flavin-containing] A Enzyme IC50 4.68 DRUG MATRIX
Serine/threonine-protein kinase pim-1 Kinase IC50 4.54 CHEMBL
Sodium/nucleoside cotransporter 1 Transporter Ki 5.29 DRUG MATRIX
Serine/threonine-protein kinase pim-3 Kinase IC50 4.69 CHEMBL
Dihydroorotate dehydrogenase (quinone), mitochondrial Enzyme IC50 8.05 CHEMBL
Dihydroorotate dehydrogenase (quinone), mitochondrial Enzyme IC50 7.52 CHEMBL

External reference:

IDSource
4021132 VUID
N0000148586 NUI
D00749 KEGG_DRUG
4021132 VANDF
4031717 VANDF
C0063041 UMLSCUI
CHEBI:6402 CHEBI
CHEMBL960 ChEMBL_ID
DB01097 DRUGBANK_ID
D000077339 MESH_DESCRIPTOR_UI
3899 PUBCHEM_CID
6825 IUPHAR_LIGAND_ID
5079 INN_ID
G162GK9U4W UNII
1310520 RXNORM
11870 MMSL
28846 MMSL
365635 MMSL
63949 MMSL
7491 MMSL
d04349 MMSL
d07905 MMSL
007642 NDDF
014643 NDDF
109143003 SNOMEDCT_US
386981009 SNOMEDCT_US
703785006 SNOMEDCT_US
703786007 SNOMEDCT_US
C1718383 UMLSCUI
DB08880 DRUGBANK_ID
54684141 PUBCHEM_CID
7761 INN_ID
C527525 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:68540 CHEBI
G162GK9U4W INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Arava HUMAN PRESCRIPTION DRUG LABEL 1 0088-2160 TABLET, FILM COATED 10 mg ORAL NDA 28 sections
Arava HUMAN PRESCRIPTION DRUG LABEL 1 0088-2161 TABLET, FILM COATED 20 mg ORAL NDA 28 sections
Arava HUMAN PRESCRIPTION DRUG LABEL 1 0088-2162 TABLET, FILM COATED 100 mg ORAL NDA 28 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 10702-277 TABLET 10 mg ORAL ANDA 18 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 10702-278 TABLET 20 mg ORAL ANDA 18 sections
leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 23155-043 TABLET 10 mg ORAL ANDA 22 sections
leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 23155-044 TABLET 20 mg ORAL ANDA 22 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 35573-447 TABLET, FILM COATED 10 mg ORAL ANDA 28 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 35573-448 TABLET, FILM COATED 20 mg ORAL ANDA 28 sections
LEFLUNOMIDE HUMAN PRESCRIPTION DRUG LABEL 1 42291-420 TABLET 10 mg ORAL ANDA 18 sections
LEFLUNOMIDE HUMAN PRESCRIPTION DRUG LABEL 1 42291-421 TABLET 20 mg ORAL ANDA 18 sections
Leflunomide Human Prescription Drug Label 1 46708-436 TABLET 10 mg ORAL ANDA 26 sections
Leflunomide Human Prescription Drug Label 1 46708-437 TABLET 20 mg ORAL ANDA 26 sections
Leflunomide Human Prescription Drug Label 1 50090-5992 TABLET, FILM COATED 20 mg ORAL ANDA 27 sections
leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 50090-7537 TABLET, FILM COATED 20 mg ORAL ANDA 24 sections
LEFLUNOMIDE HUMAN PRESCRIPTION DRUG LABEL 1 50268-477 TABLET 10 mg ORAL ANDA 18 sections
LEFLUNOMIDE HUMAN PRESCRIPTION DRUG LABEL 1 50268-478 TABLET 20 mg ORAL ANDA 18 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 54868-2319 TABLET, FILM COATED 20 mg ORAL ANDA 26 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 54868-6170 TABLET, FILM COATED 10 mg ORAL ANDA 26 sections
Leflunomide Human Prescription Drug Label 1 59651-348 TABLET, FILM COATED 10 mg ORAL ANDA 27 sections
Leflunomide Human Prescription Drug Label 1 59651-349 TABLET, FILM COATED 20 mg ORAL ANDA 27 sections
LEFLUNOMIDE HUMAN PRESCRIPTION DRUG LABEL 1 60505-2502 TABLET 10 mg ORAL ANDA 19 sections
LEFLUNOMIDE HUMAN PRESCRIPTION DRUG LABEL 1 60505-2503 TABLET 20 mg ORAL ANDA 19 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 62135-793 TABLET 10 mg ORAL ANDA 30 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 62135-793 TABLET 10 mg ORAL ANDA 30 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 62135-794 TABLET 20 mg ORAL ANDA 30 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 62135-794 TABLET 20 mg ORAL ANDA 30 sections
Leflunomide Human Prescription Drug Label 1 62332-061 TABLET 10 mg ORAL ANDA 27 sections
Leflunomide Human Prescription Drug Label 1 62332-062 TABLET 20 mg ORAL ANDA 27 sections
Leflunomide HUMAN PRESCRIPTION DRUG LABEL 1 63629-9728 TABLET, FILM COATED 10 mg ORAL ANDA 26 sections