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dimethyl sulfoxide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 906 | 67-68-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK1,JAK2,MAP2K6,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK10,MAPK7,MAPK9,MARK4,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1 | 51 | |||
| kinase-selectivity-class | ACVR2B,AURKA,AXL,BRAF,CDK9,DDR1,DYRK1B,GRK2,MAPK7,PRKDC,STK33 | 11 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pld-class | Phospholipidosis risk class (1 = positive, 0 = negative) | 0 | High | 1 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 22, 2021 | PMDA | Kyorin Pharmaceutical Co Ltd | |
| April 4, 1978 | FDA | MYLAN INSTITUTIONAL |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | G04BX13 | GENITO URINARY SYSTEM AND SEX HORMONES UROLOGICALS UROLOGICALS Other urologicals |
| ATC | M02AX03 | MUSCULO-SKELETAL SYSTEM TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN Other topical products for joint and muscular pain |
| MeSH PA | D000975 | Antioxidants |
| MeSH PA | D003451 | Cryoprotective Agents |
| MeSH PA | D012997 | Solvents |
| MeSH PA | D016166 | Free Radical Scavengers |
| MeSH PA | D020011 | Protective Agents |
| CHEBI has role | CHEBI:22333 | alkylating agent |
| CHEBI has role | CHEBI:35481 | non-narcotic analgesic |
| CHEBI has role | CHEBI:37335 | MRI contrast agent |
| CHEBI has role | CHEBI:48358 | polar aprotic solvent |
| CHEBI has role | CHEBI:48578 | radical scavenger |
| CHEBI has role | CHEBI:50247 | antidote |
| CHEBI has role | CHEBI:76971 | <em>Escherichia coli</em> metabolite |
| CHEBI has role | CHEBI:176497 | geroprotector |
Related Drugs by ATC class:
G04BX Other urologicals 10 drugs
M02AX Other topical products for joint and muscular pain 3 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Ulcerative cystitis | indication | 111409009 | DOID:13949 |
| Improvement of symptoms in patients with interstitial cystitis | indication | 197834003 | DOID:1678 |
| Disorder of lens | contraindication | 10810001 | DOID:110 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Liver function tests abnormal | contraindication | 166603001 | |
| Malignant tumor of urinary tract proper | contraindication | 363517008 | |
| Urinary Burning Sensation | contraindication |
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Dogs | Acute swelling caused by trauma | Indication |
| Horses | Acute swelling caused by trauma | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Domoso Solution | Zoetis Inc. | 1 |
| Synotic Otic Solution | Zoetis Inc. | 2 |
| Synsac Solution | Zoetis Inc. | 2 |
| Domoso Gel | Zoetis Inc. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Cereblon isoform 4 | Cytosolic other | Ki | 4.97 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| YOW8V9698H | UNII |
| 4019027 | VUID |
| N0000147300 | NUI |
| D01043 | KEGG_DRUG |
| 3455 | RXNORM |
| 4019027 | VANDF |
| C0012403 | UMLSCUI |
| CHEBI:28262 | CHEBI |
| DMS | PDB_CHEM_ID |
| CHEMBL504 | ChEMBL_ID |
| 679 | PUBCHEM_CID |
| DB01093 | DRUGBANK_ID |
| D004121 | MESH_DESCRIPTOR_UI |
| 2023 | INN_ID |
| 1614 | MMSL |
| 4608 | MMSL |
| d01431 | MMSL |
| 002883 | NDDF |
| 115535002 | SNOMEDCT_US |
| 346400003 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| RIMSO-50 | HUMAN PRESCRIPTION DRUG LABEL | 1 | 67457-177 | IRRIGANT | 0.54 g | INTRAVESICAL | NDA | 15 sections |
| Dimethyl Sulfoxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 84897-052 | IRRIGANT | 0.54 g | INTRAVESICAL | ANDA | 15 sections |