dimethyl sulfoxide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
906 67-68-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dimethyl sulfoxide
  • DMSO
  • demavet
  • demsodrox
  • methyl sulfoxide
  • zymso
A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
  • Molecular weight: 78.13
  • Formula: C2H6OS
  • CLOGP: -1.38
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA: 17.07
  • ALOGS: -0.08
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
April 4, 1978 FDA MYLAN INSTITUTIONAL
Jan. 22, 2021 PMDA Kyorin Pharmaceutical Co Ltd

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Respiratory depression 76.66 67.73 18 250 23425 64475039

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC G04BX13 GENITO URINARY SYSTEM AND SEX HORMONES
UROLOGICALS
UROLOGICALS
Other urologicals
ATC M02AX03 MUSCULO-SKELETAL SYSTEM
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Other topical products for joint and muscular pain
MeSH PA D000975 Antioxidants
MeSH PA D003451 Cryoprotective Agents
MeSH PA D016166 Free Radical Scavengers
MeSH PA D020011 Protective Agents
MeSH PA D012997 Solvents
CHEBI has role CHEBI:48358 dipolar aprotic solvent
CHEBI has role CHEBI:48578 free radical scavengers
CHEBI has role CHEBI:50247 antidotes
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:176497 geroprotectors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ulcerative cystitis indication 111409009 DOID:13949
Improvement of symptoms in patients with interstitial cystitis indication 197834003 DOID:1678
Disorder of lens contraindication 10810001 DOID:110
Kidney disease contraindication 90708001 DOID:557
Liver function tests abnormal contraindication 166603001
Malignant tumor of urinary tract proper contraindication 363517008
Urinary Burning Sensation contraindication




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs Acute swelling caused by trauma Indication
Horses Acute swelling caused by trauma Indication

🐶 Veterinary products

ProductApplicantIngredients
Domoso Solution Zoetis Inc. 1
Synotic Otic Solution Zoetis Inc. 2
Synsac Solution Zoetis Inc. 2
Domoso Gel Zoetis Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Cereblon isoform 4 Unclassified Ki 4.97 CHEMBL

External reference:

IDSource
YOW8V9698H UNII
4019027 VUID
N0000147300 NUI
D01043 KEGG_DRUG
3455 RXNORM
4019027 VANDF
C0012403 UMLSCUI
CHEBI:28262 CHEBI
DMS PDB_CHEM_ID
CHEMBL504 ChEMBL_ID
679 PUBCHEM_CID
DB01093 DRUGBANK_ID
D004121 MESH_DESCRIPTOR_UI
2023 INN_ID
1614 MMSL
4608 MMSL
d01431 MMSL
002883 NDDF
115535002 SNOMEDCT_US
346400003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
RIMSO-50 HUMAN PRESCRIPTION DRUG LABEL 1 67457-177 IRRIGANT 0.54 g INTRAVESICAL NDA 15 sections