Stem definition | Drug id | CAS RN |
---|---|---|
2676 | 1953-02-2 |
Dose | Unit | Route |
---|---|---|
0.80 | g | O |
Property | Value | Reference |
---|---|---|
BA (Bioavailability) | 63 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 1.39 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 1.48 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.45 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 55 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Aug. 11, 1988 | FDA | MISSION PHARMA |
None
None
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Nephrotic syndrome | 47.15 | 38.21 | 10 | 218 | 9557 | 64488947 |
None
Source | Code | Description |
---|---|---|
ATC | G04BX16 | GENITO URINARY SYSTEM AND SEX HORMONES UROLOGICALS UROLOGICALS Other urologicals |
FDA CS | M0289359 | N-substituted Glycines |
FDA MoA | N0000175549 | Cystine Disulfide Reduction |
FDA EPC | N0000175898 | Reducing and Complexing Thiol |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Cystinuria | indication | 85020001 | DOID:9266 |
Cystine Renal Calculi | indication | ||
Agranulocytosis | contraindication | 17182001 | DOID:12987 |
Proteinuria | contraindication | 29738008 | DOID:576 |
Goodpasture's syndrome | contraindication | 50581000 | |
Nephrotic syndrome | contraindication | 52254009 | DOID:1184 |
Leukopenia | contraindication | 84828003 | DOID:615 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Hypoalbuminemia | contraindication | 119247004 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Pregnancy, function | contraindication | 289908002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Aplastic anemia | contraindication | 306058006 | DOID:12449 |
Breastfeeding (mother) | contraindication | 413712001 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 3.57 | acidic |
pKa2 | 8.48 | acidic |
pKa3 | 13.03 | acidic |
None
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
100MG | THIOLA | MISSION PHARMA | N019569 | Aug. 11, 1988 | RX | TABLET | ORAL | June 28, 2026 | INDICATED IN COMBINATION WITH HIGH FLUID INTAKE, ALKALI, AND DIET MODIFICATION, FOR THE PREVENTION OF CYSTINE STONE FORMATION IN PEDIATRIC PATIENTS 20KG TO 9 YEARS OF AGE W/SEVERE HOMOZYGOUS CYSTINURIA, WHO ARE NOT RESPONSIVE TO THESE MEASURES ALONE |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Angiotensin-converting enzyme | Enzyme | IC50 | 5.72 | CHEMBL |
ID | Source |
---|---|
4019475 | VUID |
N0000147595 | NUI |
D01430 | KEGG_DRUG |
4019475 | VANDF |
C0025405 | UMLSCUI |
CHEBI:32229 | CHEBI |
WJZ | PDB_CHEM_ID |
CHEMBL1314 | ChEMBL_ID |
DB06823 | DRUGBANK_ID |
D008625 | MESH_DESCRIPTOR_UI |
5483 | PUBCHEM_CID |
3574 | INN_ID |
C5W04GO61S | UNII |
6765 | RXNORM |
190283 | MMSL |
5587 | MMSL |
d01418 | MMSL |
002371 | NDDF |
109106000 | SNOMEDCT_US |
397225004 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Tiopronin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7909 | TABLET, SUGAR COATED | 100 mg | ORAL | ANDA | 22 sections |
Thiola | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0178-0900 | TABLET, SUGAR COATED | 100 mg | ORAL | NDA | 15 sections |
Thiola EC | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0178-0901 | TABLET, DELAYED RELEASE | 300 mg | ORAL | NDA | 25 sections |
Thiola EC | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0178-0902 | TABLET, DELAYED RELEASE | 100 mg | ORAL | NDA | 25 sections |