DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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Structure 🔎
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
dapoxetine 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
serotonin and/or norepinephrine reuptake inhibitors, fluoxetine derivatives
4381
119356-77-3
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
dapoxetine
priligy
dapoxetine hydrochloride
LY-210448
selective serotonin reuptake inhibitor (SSRI) that was designed specifically for premature ejaculation
Molecular weight: 305.42
Formula: C21H23NO
CLOGP: 5.34
LIPINSKI: 1
HAC: 2
HDO: 0
TPSA: 12.47
ALOGS: -5.56
ROTB: 6
Drug dosage:
Dose
Unit
Route
30
mg
O
ADMET properties:
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Property
Value
Reference
S (Water solubility)
25.64 mg/mL
Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System)
1
Bocci G, Oprea TI, Benet LZ
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Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
G04BX14
GENITO URINARY SYSTEM AND SEX HORMONES
UROLOGICALS
UROLOGICALS
Other urologicals
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Premature ejaculation
indication
44001008
DOID:13709
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
8.52
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Sodium-dependent serotonin transporter
Transporter
P31645
SC6A4_HUMAN
INHIBITOR
IC50
8.95
IUPHAR
IUPHAR
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External reference:
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100
entries
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ID
Source
015051
NDDF
015052
NDDF
129938-20-1
SECONDARY_CAS_RN
6834
INN_ID
702794006
SNOMEDCT_US
71353
PUBCHEM_CID
734472002
SNOMEDCT_US
7901
IUPHAR_LIGAND_ID
C0215087
UMLSCUI
C080598
MESH_SUPPLEMENTAL_RECORD_UI
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Pharmaceutical products:
None
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dapoxetine