dapoxetine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
serotonin and/or norepinephrine reuptake inhibitors, fluoxetine derivatives	4381	119356-77-3

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

dapoxetine
priligy
dapoxetine hydrochloride
LY-210448

selective serotonin reuptake inhibitor (SSRI) that was designed specifically for premature ejaculation

Molecular weight: 305.42
Formula: C21H23NO
CLOGP: 5.34
LIPINSKI: 1
HAC: 2
HDO: 0
TPSA: 12.47
ALOGS: -5.56
ROTB: 6

Drug dosage:

Dose	Unit	Route
30	mg	O

ADMET properties:

Property	Value	Reference
S (Water solubility)	25.64 mg/mL	Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Bocci G, Oprea TI, Benet LZ
BA (Bioavailability)	45 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,AKT1,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MET,MTOR,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKDC,SIK2,SIK3,STK33,TEK,TGFBR1,TTK	45
kinase-selectivity-class	AXL,BRAF,ERBB2,GRK2,PDK4,PIK3CB,PIK3CD	7
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sudden hearing loss	35.57	32.59	4	6	1085	42620240

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sudden hearing loss	36.45	33.18	4	6	2265	110587024

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	G04BX14	GENITO URINARY SYSTEM AND SEX HORMONES UROLOGICALS UROLOGICALS Other urologicals
CHEBI has role	CHEBI:35620	vasodilator agent

Related Drugs by ATC class:

G04BX Other urologicals 10 drugs

acetohydroxamic acid dimethyl sulfoxide magnesium hydroxide methenamine pentosan polysulfate phenazopyridine phenyl salicylate salicylic acid succinimide tiopronin

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Premature ejaculation	indication	44001008	DOID:13709

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.52	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN	INHIBITOR	IC50	8.95		IUPHAR	IUPHAR

External reference:

ID	Source
C0215087	UMLSCUI
CHEBI:135962	CHEBI
D03649	KEGG_DRUG
CHEMBL2110900	ChEMBL_ID
CHEMBL2106574	ChEMBL_ID
DB04884	DRUGBANK_ID
C080598	MESH_SUPPLEMENTAL_RECORD_UI
7901	IUPHAR_LIGAND_ID
6834	INN_ID
GB2433A4M3	UNII
71353	PUBCHEM_CID
015051	NDDF
015052	NDDF
702794006	SNOMEDCT_US
734472002	SNOMEDCT_US
129938-20-1	SECONDARY_CAS_RN
GB2433A4M3	INXIGHT DRUGS

Pharmaceutical products:

None