methenamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 3344 | 100-97-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An anti-infective agent most commonly used in the treatment of urinary tract infections. Its anti-infective action derives from the slow release of formaldehyde by hydrolysis at acidic pH. (From Martindale, The Extra Pharmacopoeia, 30th ed, p173)
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 2 | g | O |
| 3 | g | O |
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| July 5, 1967 | FDA | CNTY LINE PHARMS |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Urinary tract infection | 84.32 | 21.93 | 69 | 1871 | 223951 | 50379233 |
| Thyroid cancer metastatic | 29.76 | 21.93 | 5 | 1935 | 120 | 50603064 |
| Drug monitoring procedure not performed | 28.76 | 21.93 | 6 | 1934 | 473 | 50602711 |
| Hyperammonaemia | 26.36 | 21.93 | 9 | 1931 | 4715 | 50598469 |
| Hypothermia | 24.39 | 21.93 | 11 | 1929 | 12005 | 50591179 |
| Urine analysis abnormal | 23.15 | 21.93 | 8 | 1932 | 4342 | 50598842 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Urinary tract infection | 37.43 | 36.06 | 20 | 481 | 72334 | 29501692 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Urinary tract infection | 68.31 | 21.54 | 58 | 2049 | 231538 | 64265087 |
| Thyroid cancer metastatic | 30.00 | 21.54 | 5 | 2102 | 135 | 64496490 |
| Drug monitoring procedure not performed | 26.49 | 21.54 | 6 | 2101 | 816 | 64495809 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01XX05 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER ANTIBACTERIALS Other antibacterials |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000892 | Anti-Infective Agents, Urinary |
| CHEBI has role | CHEBI:36047 | antibacterial drugs |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Urinary tract infectious disease | indication | 68566005 | |
| Prevention of Bacterial Urinary Tract Infection | indication | ||
| Gastritis | contraindication | 4556007 | DOID:4029 |
| Hypocalcemia | contraindication | 5291005 | |
| Severe chronic ulcerative colitis | contraindication | 14311001 | |
| Disorder of autonomic nervous system | contraindication | 15241006 | |
| Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
| Hyperphosphatemia | contraindication | 20165001 | DOID:0050459 |
| Glaucoma | contraindication | 23986001 | DOID:1686 |
| Toxic megacolon | contraindication | 28536002 | DOID:1770 |
| Atony of colon | contraindication | 29479008 | |
| Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
| Glomerulonephritis | contraindication | 36171008 | DOID:2921 |
| Acute hepatitis | contraindication | 37871000 | |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Hypernatremia | contraindication | 39355002 | |
| Hypovolemic shock | contraindication | 39419009 | |
| Gastrointestinal ulcer | contraindication | 40845000 | |
| Body fluid retention | contraindication | 43498006 | |
| Uremia | contraindication | 44730006 | DOID:4676 |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Achalasia of esophagus | contraindication | 45564002 | DOID:9164 |
| Chronic heart failure | contraindication | 48447003 | |
| Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
| Vitamin K deficiency | contraindication | 52675005 | DOID:11249 |
| Nasal polyp | contraindication | 52756005 | |
| Paralytic ileus | contraindication | 55525008 | DOID:8442 |
| Acute nephropathy | contraindication | 58574008 | |
| Hepatic failure | contraindication | 59927004 | |
| Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Factor II deficiency | contraindication | 73975000 | |
| Gastrointestinal hemorrhage | contraindication | 74474003 | |
| Thrombotic thrombocytopenic purpura | contraindication | 78129009 | DOID:10772 |
| Hiatal hernia | contraindication | 84089009 | DOID:12642 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Thyrotoxicosis | contraindication | 90739004 | DOID:7997 |
| Hemophilia | contraindication | 90935002 | |
| Myasthenia gravis | contraindication | 91637004 | DOID:437 |
| Anemia due to enzyme deficiency | contraindication | 111577008 | |
| Deficiency of glucose-6-phosphate dehydrogenase | contraindication | 124134002 | DOID:2862 |
| Liver function tests abnormal | contraindication | 166603001 | |
| Gastroesophageal reflux disease | contraindication | 235595009 | DOID:8534 |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Bladder outflow obstruction | contraindication | 236645006 | |
| Pyloric obstruction | contraindication | 244815007 | |
| Benign prostatic hyperplasia | contraindication | 266569009 | |
| Edema | contraindication | 267038008 | |
| Anemia | contraindication | 271737000 | DOID:2355 |
| Pregnancy, function | contraindication | 289908002 | |
| Cardiovascular event risk | contraindication | 395112001 | |
| Breastfeeding (mother) | contraindication | 413712001 | |
| Disorder of coronary artery | contraindication | 414024009 | |
| Fever greater than 100.4 Fahrenheit | contraindication | 426000000 | |
| Severe dehydration | contraindication | 450316000 |
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Cats | Urinary tract infections | Indication |
| Cats | Management of complications resulting from surgical manipulations of the urinary tract | Indication |
| Dogs | Urinary tract infections | Indication |
| Dogs | Management of complications resulting from surgical manipulations of the urinary tract | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Mesulfin Tablets | Zoetis Inc. | 2 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.59 | Basic |
| pKa2 | 5.59 | Basic |
| pKa3 | 1.09 | Basic |
| pKa4 | 1.0 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4018578 | VUID |
| N0000146894 | NUI |
| D00393 | KEGG_DRUG |
| 5714-73-8 | SECONDARY_CAS_RN |
| 587-23-5 | SECONDARY_CAS_RN |
| 4017868 | VANDF |
| 4017869 | VANDF |
| 4018578 | VANDF |
| C0025638 | UMLSCUI |
| CHEBI:6824 | CHEBI |
| CHEMBL1201270 | ChEMBL_ID |
| DB06799 | DRUGBANK_ID |
| CHEMBL1201104 | ChEMBL_ID |
| CHEMBL3833312 | ChEMBL_ID |
| D008709 | MESH_DESCRIPTOR_UI |
| 4101 | PUBCHEM_CID |
| 119 | INN_ID |
| C011481 | MESH_SUPPLEMENTAL_RECORD_UI |
| C023055 | MESH_SUPPLEMENTAL_RECORD_UI |
| 10913 | IUPHAR_LIGAND_ID |
| J50OIX95QV | UNII |
| 161623 | RXNORM |
| 5069 | MMSL |
| 5070 | MMSL |
| 5071 | MMSL |
| 72179 | MMSL |
| 941 | MMSL |
| 945 | MMSL |
| d00106 | MMSL |
| 002861 | NDDF |
| 002862 | NDDF |
| 002863 | NDDF |
| 372773008 | SNOMEDCT_US |
| 55741006 | SNOMEDCT_US |
| 56123002 | SNOMEDCT_US |
| 68293009 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| URELLE | HUMAN PRESCRIPTION DRUG LABEL | 5 | 0037-6321 | TABLET | 81 mg | ORAL | Unapproved drug other | 12 sections |
| URIBEL | HUMAN PRESCRIPTION DRUG LABEL | 5 | 0076-0111 | CAPSULE | 120 mg | ORAL | unapproved drug other | 20 sections |
| Hyophen | HUMAN PRESCRIPTION DRUG LABEL | 5 | 0076-0901 | TABLET | 81.60 mg | ORAL | unapproved drug other | 19 sections |
| Phosphasal | HUMAN PRESCRIPTION DRUG LABEL | 5 | 0076-0902 | TABLET | 81.60 mg | ORAL | unapproved drug other | 20 sections |
| Ustell | HUMAN PRESCRIPTION DRUG LABEL | 5 | 0076-0903 | CAPSULE | 120 mg | ORAL | unapproved drug other | 20 sections |
| Methenamine Hippurate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1754 | TABLET | 1 g | ORAL | ANDA | 12 sections |
| Utira-C | HUMAN PRESCRIPTION DRUG LABEL | 5 | 0178-0513 | TABLET | 81.60 mg | ORAL | unapproved drug other | 12 sections |
| URIBEL | HUMAN PRESCRIPTION DRUG LABEL | 5 | 0178-0740 | CAPSULE | 118 mg | ORAL | unapproved drug other | 21 sections |
| Walgreens Antibacterial Plus Urinary Pain Relief | HUMAN OTC DRUG LABEL | 2 | 0363-4404 | TABLET | 162 mg | ORAL | unapproved drug other | 10 sections |
| UROGESIC BLUE | HUMAN PRESCRIPTION DRUG LABEL | 4 | 0485-0151 | TABLET, COATED | 81.60 mg | ORAL | unapproved drug other | 18 sections |
| UROGESIC BLUE | HUMAN PRESCRIPTION DRUG LABEL | 4 | 0485-0151 | TABLET, COATED | 81.60 mg | ORAL | unapproved drug other | 18 sections |
| Preferred Antibacterial Plus Urinary Pain Relief | HUMAN OTC DRUG LABEL | 2 | 10956-763 | TABLET | 162 mg | ORAL | unapproved drug other | 10 sections |
| Rite Aid Antibacterial Plus Urinary Pain Relief | HUMAN OTC DRUG LABEL | 2 | 11822-4892 | TABLET | 162 mg | ORAL | unapproved drug other | 10 sections |
| Methenamine Mandelate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13925-107 | TABLET, FILM COATED | 1000 mg | ORAL | UNAPPROVED DRUG OTHER | 15 sections |
| Methenamine Mandelate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13925-107 | TABLET, FILM COATED | 1000 mg | ORAL | UNAPPROVED DRUG OTHER | 15 sections |
| UroAv-81 | HUMAN PRESCRIPTION DRUG LABEL | 5 | 15338-502 | TABLET | 81 mg | ORAL | unapproved drug other | 18 sections |
| UroAv-B | HUMAN PRESCRIPTION DRUG LABEL | 5 | 15338-503 | CAPSULE | 118 mg | ORAL | unapproved drug other | 18 sections |
| HIPREX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 30698-477 | TABLET | 1 g | ORAL | NDA | 13 sections |
| TopCare Antibacterial Plus Urinary Pain Relief | HUMAN OTC DRUG LABEL | 2 | 36800-314 | TABLET | 162 mg | ORAL | unapproved drug other | 10 sections |
| Meijer Antibacterial Plus Urinary Pain Relief | HUMAN OTC DRUG LABEL | 2 | 41250-557 | TABLET | 162 mg | ORAL | unapproved drug other | 10 sections |
| UroAv-81 | HUMAN PRESCRIPTION DRUG LABEL | 5 | 42291-851 | TABLET | 81 mg | ORAL | unapproved drug other | 18 sections |
| Methenamine Hippurate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42571-332 | TABLET | 1000 mg | ORAL | ANDA | 11 sections |
| Methenamine Mandelate | Human Prescription Drug Label | 1 | 42799-105 | TABLET | 500 mg | ORAL | UNAPPROVED DRUG OTHER | 13 sections |
| Methenamine Mandelate | Human Prescription Drug Label | 1 | 42799-106 | TABLET | 1000 mg | ORAL | UNAPPROVED DRUG OTHER | 13 sections |
| Methenamine Hippurate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43199-020 | TABLET | 1 g | ORAL | NDA | 23 sections |
| Hyophen | HUMAN PRESCRIPTION DRUG LABEL | 5 | 44523-741 | TABLET | 81.60 mg | ORAL | unapproved drug other | 19 sections |
| Phosphasal | HUMAN PRESCRIPTION DRUG LABEL | 5 | 44523-742 | TABLET | 81.60 mg | ORAL | unapproved drug other | 20 sections |
| Ustell | HUMAN PRESCRIPTION DRUG LABEL | 5 | 44523-743 | CAPSULE | 120 mg | ORAL | unapproved drug other | 20 sections |
| Good Neighbor Antibacterial Plus Urinary Pain Relief | HUMAN OTC DRUG LABEL | 2 | 46122-622 | TABLET | 162 mg | ORAL | unapproved drug other | 10 sections |
| Methenamine Hippurate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 47781-577 | TABLET | 1 g | ORAL | NDA | 22 sections |