idrocilamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1418 6961-46-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • idrocilamide
  • brolitene
  • srilane
  • Molecular weight: 191.23
  • Formula: C11H13NO2
  • CLOGP: 0.98
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 49.33
  • ALOGS: -2.58
  • ROTB: 4

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.11 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.99 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.35 hours Lombardo F, Berellini G, Obach RS
BA (Bioavailability) 30 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 1.479 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.551 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 97.051 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 63.973 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 51.210 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 70.480 % High 1
herg hERG pIC50 3.508 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 54.450 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 57.016 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 46.270 % High 1
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,MAP3K21,MAP3K7,MAPK7,MAPK9,NTRK2,PAK4,PDK1,PDK2,PDK4,PIK3CB,PRKDC,SIK2,SIK3,STK33,TEK,TTK 34
kinase-selectivity-class AXL,GRK2 2
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.172 High 1
mh-clint Mouse hepatocyte intrinsic clearance 163.305 High 1
mppb Mouse plasma protein binding (% unbound) 54.480 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.274 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 52.190 % High 1
rh-clint Rat hepatocyte intrinsic clearance 68.707 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 97.460 % High 1
rppb Rat plasma protein binding (% unbound) 54.140 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 1061.696 uM High 1

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M02AX05 MUSCULO-SKELETAL SYSTEM
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Other topical products for joint and muscular pain

Related Drugs by ATC class:

M02AX Other topical products for joint and muscular pain 3 drugs
dimethyl sulfoxidetolazolinetolperisone

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.86 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D08063 KEGG_DRUG
C0054086 UMLSCUI
CHEMBL102358 ChEMBL_ID
DB13297 DRUGBANK_ID
1550874 PUBCHEM_CID
C004560 MESH_SUPPLEMENTAL_RECORD_UI
3547 INN_ID
6C816LUB1O UNII
19729 RXNORM
005257 NDDF
16311000122105 SNOMEDCT_US
CHEBI:134842 CHEBI

Pharmaceutical products:

None