dimetacrine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
acridine derivatives 902 4757-55-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dimetacrine
  • dimetacrino
  • dimetacrinum
  • dimethacrin
  • dimethacrine
minor descriptor (75-84); on-line & Index Medicus search ACRIDINES (75-84); RN given refers to parent cpd without isomeric designation
  • Molecular weight: 294.44
  • Formula: C20H26N2
  • CLOGP: 5.67
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 0
  • TPSA: 6.48
  • ALOGS: -3.93
  • ROTB: 4

Drug dosage:

DoseUnitRoute
0.15 g O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N06AA18 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Non-selective monoamine reuptake inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.04 Basic
pKa2 4.04 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Apical membrane antigen 1 Unclassified IC50 4.55 CHEMBL

External reference:

IDSource
D02565 KEGG_DRUG
C0058199 UMLSCUI
CHEBI:135233 CHEBI
CHEMBL1328913 ChEMBL_ID
DB08996 DRUGBANK_ID
C100110 MESH_SUPPLEMENTAL_RECORD_UI
94280 PUBCHEM_CID
2195 INN_ID
O341NY501N UNII

Pharmaceutical products:

None