Stem definition | Drug id | CAS RN |
---|---|---|
substances of the imipramine group | 701 | 303-49-1 |
Dose | Unit | Route |
---|---|---|
0.10 | g | O |
0.10 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 13.24 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 51 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 13 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 8.20 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.03 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 26 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 29, 1989 | FDA | MALLINCKRODT LLC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Coma | 214.31 | 16.20 | 137 | 10745 | 59518 | 56221667 |
Intentional overdose | 190.73 | 16.20 | 134 | 10748 | 67983 | 56213202 |
Serotonin syndrome | 173.44 | 16.20 | 90 | 10792 | 26400 | 56254785 |
Drug interaction | 149.74 | 16.20 | 193 | 10689 | 209562 | 56071623 |
Suicide attempt | 130.65 | 16.20 | 100 | 10782 | 57736 | 56223449 |
Overdose | 129.55 | 16.20 | 129 | 10753 | 105701 | 56175484 |
Bezoar | 116.99 | 16.20 | 31 | 10851 | 1337 | 56279848 |
Poisoning deliberate | 111.66 | 16.20 | 49 | 10833 | 9904 | 56271281 |
Toxicity to various agents | 102.11 | 16.20 | 167 | 10715 | 224397 | 56056788 |
Intentional self-injury | 98.66 | 16.20 | 61 | 10821 | 24931 | 56256254 |
Depressed level of consciousness | 86.55 | 16.20 | 78 | 10804 | 56355 | 56224830 |
Antipsychotic drug level increased | 82.87 | 16.20 | 29 | 10853 | 3213 | 56277972 |
Neuroleptic malignant syndrome | 77.96 | 16.20 | 40 | 10842 | 11438 | 56269747 |
Sopor | 74.88 | 16.20 | 48 | 10834 | 20874 | 56260311 |
Electrocardiogram QT prolonged | 67.54 | 16.20 | 67 | 10815 | 54521 | 56226664 |
Tachycardia | 65.47 | 16.20 | 91 | 10791 | 105785 | 56175400 |
Antidepressant drug level increased | 58.65 | 16.20 | 13 | 10869 | 260 | 56280925 |
Altered state of consciousness | 56.79 | 16.20 | 42 | 10840 | 22979 | 56258206 |
Hypertonia | 55.32 | 16.20 | 23 | 10859 | 4069 | 56277116 |
International normalised ratio abnormal | 55.06 | 16.20 | 21 | 10861 | 2967 | 56278218 |
Hyperthermia | 50.90 | 16.20 | 27 | 10855 | 8258 | 56272927 |
Suicidal ideation | 50.50 | 16.20 | 59 | 10823 | 57683 | 56223502 |
Pain | 49.49 | 16.20 | 34 | 10848 | 663150 | 55618035 |
Drug abuse | 49.27 | 16.20 | 63 | 10819 | 67547 | 56213638 |
Cerebellar syndrome | 48.61 | 16.20 | 20 | 10862 | 3447 | 56277738 |
Agitation | 48.58 | 16.20 | 57 | 10825 | 55979 | 56225206 |
Somnolence | 48.20 | 16.20 | 101 | 10781 | 163312 | 56117873 |
Myoclonus | 47.38 | 16.20 | 32 | 10850 | 15171 | 56266014 |
Tremor | 46.91 | 16.20 | 84 | 10798 | 121005 | 56160180 |
Rheumatoid arthritis | 46.20 | 16.20 | 9 | 10873 | 382595 | 55898590 |
Sinus tachycardia | 44.56 | 16.20 | 36 | 10846 | 22408 | 56258777 |
Akathisia | 44.31 | 16.20 | 25 | 10857 | 8627 | 56272558 |
Livedo reticularis | 42.23 | 16.20 | 16 | 10866 | 2219 | 56278966 |
Confusional state | 42.10 | 16.20 | 111 | 10771 | 208044 | 56073141 |
Hypotension | 39.40 | 16.20 | 122 | 10760 | 250386 | 56030799 |
Polyuria | 39.16 | 16.20 | 22 | 10860 | 7529 | 56273656 |
Joint swelling | 39.06 | 16.20 | 5 | 10877 | 289795 | 55991390 |
Hyposmia | 38.82 | 16.20 | 11 | 10871 | 610 | 56280575 |
Psychomotor hyperactivity | 38.81 | 16.20 | 24 | 10858 | 9796 | 56271389 |
Ventricular dyskinesia | 38.01 | 16.20 | 8 | 10874 | 124 | 56281061 |
Obsessive-compulsive disorder | 37.56 | 16.20 | 17 | 10865 | 3689 | 56277496 |
Hyperchloraemia | 36.96 | 16.20 | 11 | 10871 | 726 | 56280459 |
Mental disorder | 36.89 | 16.20 | 33 | 10849 | 23571 | 56257614 |
Arthralgia | 35.68 | 16.20 | 27 | 10855 | 501642 | 55779543 |
Alopecia | 35.20 | 16.20 | 7 | 10875 | 293451 | 55987734 |
Pneumonia aspiration | 33.25 | 16.20 | 36 | 10846 | 32375 | 56248810 |
Poisoning | 33.00 | 16.20 | 24 | 10858 | 12789 | 56268396 |
Urinary retention | 32.03 | 16.20 | 33 | 10849 | 28041 | 56253144 |
Parkinsonism | 31.93 | 16.20 | 21 | 10861 | 9525 | 56271660 |
Hypotonia | 31.26 | 16.20 | 20 | 10862 | 8657 | 56272528 |
Fatigue | 30.70 | 16.20 | 67 | 10815 | 788485 | 55492700 |
Diarrhoea | 30.36 | 16.20 | 48 | 10834 | 638459 | 55642726 |
Restlessness | 29.88 | 16.20 | 31 | 10851 | 26555 | 56254630 |
Muscle rigidity | 29.81 | 16.20 | 21 | 10861 | 10650 | 56270535 |
Disturbance in attention | 29.70 | 16.20 | 34 | 10848 | 32506 | 56248679 |
Cor pulmonale acute | 29.60 | 16.20 | 8 | 10874 | 372 | 56280813 |
Drug withdrawal syndrome neonatal | 29.52 | 16.20 | 12 | 10870 | 2004 | 56279181 |
Mydriasis | 29.11 | 16.20 | 21 | 10861 | 11050 | 56270135 |
Psychomotor skills impaired | 28.83 | 16.20 | 12 | 10870 | 2128 | 56279057 |
Newborn persistent pulmonary hypertension | 28.43 | 16.20 | 7 | 10875 | 224 | 56280961 |
Miosis | 28.33 | 16.20 | 17 | 10865 | 6575 | 56274610 |
Post-anoxic myoclonus | 27.49 | 16.20 | 5 | 10877 | 34 | 56281151 |
Inappropriate antidiuretic hormone secretion | 27.16 | 16.20 | 22 | 10860 | 13734 | 56267451 |
Urine osmolarity increased | 27.07 | 16.20 | 6 | 10876 | 120 | 56281065 |
Blood prolactin increased | 26.80 | 16.20 | 13 | 10869 | 3296 | 56277889 |
Drug level increased | 26.65 | 16.20 | 26 | 10856 | 20699 | 56260486 |
Otorrhoea | 26.46 | 16.20 | 10 | 10872 | 1377 | 56279808 |
Hallucination, auditory | 26.14 | 16.20 | 20 | 10862 | 11504 | 56269681 |
Retroplacental haematoma | 25.83 | 16.20 | 6 | 10876 | 149 | 56281036 |
Shock | 25.62 | 16.20 | 26 | 10856 | 21702 | 56259483 |
Psychomotor retardation | 25.53 | 16.20 | 13 | 10869 | 3656 | 56277529 |
Onychophagia | 25.02 | 16.20 | 5 | 10877 | 59 | 56281126 |
Circulatory collapse | 24.72 | 16.20 | 25 | 10857 | 20778 | 56260407 |
Hepatocellular injury | 24.69 | 16.20 | 28 | 10854 | 26486 | 56254699 |
Cyanosis | 24.50 | 16.20 | 22 | 10860 | 15788 | 56265397 |
Product dose omission issue | 24.29 | 16.20 | 5 | 10877 | 204748 | 56076437 |
Depression | 24.03 | 16.20 | 83 | 10799 | 180034 | 56101151 |
Mania | 23.97 | 16.20 | 19 | 10863 | 11501 | 56269684 |
Spasmodic dysphonia | 23.67 | 16.20 | 5 | 10877 | 79 | 56281106 |
Rash | 23.46 | 16.20 | 37 | 10845 | 493010 | 55788175 |
Contraindicated product administered | 23.27 | 16.20 | 4 | 10878 | 186282 | 56094903 |
Electrocardiogram QRS complex prolonged | 23.24 | 16.20 | 14 | 10868 | 5453 | 56275732 |
Nasopharyngitis | 23.11 | 16.20 | 7 | 10875 | 220952 | 56060233 |
Apathy | 23.03 | 16.20 | 16 | 10866 | 7938 | 56273247 |
Hypokalaemia | 22.88 | 16.20 | 54 | 10828 | 94383 | 56186802 |
Nephrogenic diabetes insipidus | 22.80 | 16.20 | 8 | 10874 | 892 | 56280293 |
Treatment failure | 22.79 | 16.20 | 3 | 10879 | 170389 | 56110796 |
Lactic acidosis | 22.74 | 16.20 | 31 | 10851 | 35315 | 56245870 |
Therapeutic product effect decreased | 22.63 | 16.20 | 3 | 10879 | 169449 | 56111736 |
Asphyxia | 22.50 | 16.20 | 14 | 10868 | 5775 | 56275410 |
Hyponatraemia | 22.18 | 16.20 | 56 | 10826 | 102083 | 56179102 |
Peripheral swelling | 21.88 | 16.20 | 9 | 10873 | 234717 | 56046468 |
Arthropathy | 21.58 | 16.20 | 6 | 10876 | 200269 | 56080916 |
Anxiety | 21.54 | 16.20 | 84 | 10798 | 193088 | 56088097 |
Paralogism | 21.42 | 16.20 | 4 | 10878 | 32 | 56281153 |
Swelling | 21.08 | 16.20 | 10 | 10872 | 239761 | 56041424 |
Cholestasis | 21.06 | 16.20 | 26 | 10856 | 26887 | 56254298 |
Right ventricular dilatation | 20.99 | 16.20 | 8 | 10874 | 1128 | 56280057 |
Hyperhidrosis | 20.87 | 16.20 | 52 | 10830 | 94036 | 56187149 |
Tardive dyskinesia | 20.58 | 16.20 | 15 | 10867 | 8016 | 56273169 |
Drug hypersensitivity | 20.58 | 16.20 | 14 | 10868 | 275191 | 56005994 |
Foetal arrhythmia | 20.37 | 16.20 | 5 | 10877 | 158 | 56281027 |
Heat stroke | 20.25 | 16.20 | 7 | 10875 | 747 | 56280438 |
Dialysis | 20.18 | 16.20 | 16 | 10866 | 9686 | 56271499 |
Stereotypy | 19.87 | 16.20 | 6 | 10876 | 416 | 56280769 |
Infection | 19.78 | 16.20 | 7 | 10875 | 200199 | 56080986 |
Drug screen false positive | 19.68 | 16.20 | 7 | 10875 | 813 | 56280372 |
Respiratory depression | 18.67 | 16.20 | 17 | 10865 | 12418 | 56268767 |
Hypernatraemia | 18.42 | 16.20 | 13 | 10869 | 6607 | 56274578 |
Hyporesponsive to stimuli | 18.34 | 16.20 | 7 | 10875 | 991 | 56280194 |
Acquired haemophilia | 18.16 | 16.20 | 7 | 10875 | 1017 | 56280168 |
Rhabdomyolysis | 18.07 | 16.20 | 30 | 10852 | 40628 | 56240557 |
Morbid thoughts | 18.03 | 16.20 | 6 | 10876 | 570 | 56280615 |
Loss of consciousness | 17.83 | 16.20 | 54 | 10828 | 109295 | 56171890 |
Toxic skin eruption | 17.53 | 16.20 | 16 | 10866 | 11723 | 56269462 |
Headache | 17.45 | 16.20 | 53 | 10829 | 558991 | 55722194 |
Otitis media | 17.31 | 16.20 | 11 | 10871 | 4705 | 56276480 |
Hyperprolactinaemia | 17.20 | 16.20 | 10 | 10872 | 3651 | 56277534 |
Abdominal discomfort | 17.14 | 16.20 | 17 | 10865 | 277257 | 56003928 |
Intestinal gangrene | 17.12 | 16.20 | 3 | 10879 | 16 | 56281169 |
Psychiatric symptom | 17.04 | 16.20 | 11 | 10871 | 4833 | 56276352 |
Anticholinergic syndrome | 16.88 | 16.20 | 8 | 10874 | 1926 | 56279259 |
Junctional ectopic tachycardia | 16.73 | 16.20 | 4 | 10878 | 113 | 56281072 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Obsessive-compulsive disorder | 299.12 | 20.90 | 90 | 7716 | 4847 | 31684691 |
Suicide attempt | 271.20 | 20.90 | 147 | 7659 | 37101 | 31652437 |
Therapeutic product effect variable | 260.09 | 20.90 | 66 | 7740 | 1872 | 31687666 |
Antipsychotic drug level below therapeutic | 252.65 | 20.90 | 65 | 7741 | 1950 | 31687588 |
Disinhibition | 238.56 | 20.90 | 66 | 7740 | 2627 | 31686911 |
Euphoric mood | 219.55 | 20.90 | 71 | 7735 | 4849 | 31684689 |
Akathisia | 203.70 | 20.90 | 74 | 7732 | 7179 | 31682359 |
Increased appetite | 186.66 | 20.90 | 67 | 7739 | 6277 | 31683261 |
Toxicity to various agents | 132.50 | 20.90 | 191 | 7615 | 181296 | 31508242 |
Intentional overdose | 132.22 | 20.90 | 97 | 7709 | 41292 | 31648246 |
Serotonin syndrome | 103.79 | 20.90 | 62 | 7744 | 18711 | 31670827 |
Coma | 99.92 | 20.90 | 82 | 7724 | 41068 | 31648470 |
Poisoning deliberate | 95.17 | 20.90 | 43 | 7763 | 7301 | 31682237 |
Neuroleptic malignant syndrome | 91.40 | 20.90 | 55 | 7751 | 16814 | 31672724 |
Dyslipidaemia | 81.39 | 20.90 | 37 | 7769 | 6369 | 31683169 |
Electrocardiogram QT prolonged | 80.47 | 20.90 | 70 | 7736 | 37917 | 31651621 |
Therapeutic product effect incomplete | 79.70 | 20.90 | 74 | 7732 | 43622 | 31645916 |
Leukaemia | 76.78 | 20.90 | 31 | 7775 | 3994 | 31685544 |
Obesity | 72.85 | 20.90 | 41 | 7765 | 11059 | 31678479 |
Leukopenia | 69.15 | 20.90 | 78 | 7728 | 57750 | 31631788 |
Prescribed overdose | 68.72 | 20.90 | 37 | 7769 | 9155 | 31680383 |
Weight increased | 67.21 | 20.90 | 92 | 7714 | 82855 | 31606683 |
Sopor | 63.42 | 20.90 | 38 | 7768 | 11514 | 31678024 |
Intentional self-injury | 60.93 | 20.90 | 39 | 7767 | 13276 | 31676262 |
Extrapyramidal disorder | 52.65 | 20.90 | 34 | 7772 | 11744 | 31677794 |
Somnolence | 50.60 | 20.90 | 89 | 7717 | 99356 | 31590182 |
Agitation | 46.75 | 20.90 | 62 | 7744 | 54107 | 31635431 |
Overdose | 45.97 | 20.90 | 78 | 7728 | 84586 | 31604952 |
Compartment syndrome | 42.24 | 20.90 | 18 | 7788 | 2653 | 31686885 |
Drug interaction | 40.63 | 20.90 | 128 | 7678 | 208415 | 31481123 |
Schizoaffective disorder | 39.49 | 20.90 | 14 | 7792 | 1261 | 31688277 |
Renal hypertension | 38.77 | 20.90 | 9 | 7797 | 173 | 31689365 |
Loose associations | 35.91 | 20.90 | 7 | 7799 | 55 | 31689483 |
Mania | 35.00 | 20.90 | 24 | 7782 | 9153 | 31680385 |
Brachial plexus injury | 34.05 | 20.90 | 7 | 7799 | 74 | 31689464 |
Tremor | 30.86 | 20.90 | 62 | 7744 | 76358 | 31613180 |
Fatigue | 30.39 | 20.90 | 23 | 7783 | 335183 | 31354355 |
Rhabdomyolysis | 29.86 | 20.90 | 55 | 7751 | 63526 | 31626012 |
Hypothermia | 29.58 | 20.90 | 22 | 7784 | 9522 | 31680016 |
Aggression | 28.10 | 20.90 | 40 | 7766 | 37251 | 31652287 |
Hypertonia neonatal | 26.54 | 20.90 | 8 | 7798 | 431 | 31689107 |
Inappropriate antidiuretic hormone secretion | 26.15 | 20.90 | 22 | 7784 | 11365 | 31678173 |
Coma scale abnormal | 25.09 | 20.90 | 14 | 7792 | 3709 | 31685829 |
Pneumonia | 24.49 | 20.90 | 28 | 7778 | 335284 | 31354254 |
Diarrhoea | 24.07 | 20.90 | 31 | 7775 | 352378 | 31337160 |
Cataplexy | 23.69 | 20.90 | 7 | 7799 | 352 | 31689186 |
Cough | 23.05 | 20.90 | 3 | 7803 | 134811 | 31554727 |
Drug ineffective | 22.99 | 20.90 | 171 | 7635 | 395402 | 31294136 |
Depressed level of consciousness | 22.84 | 20.90 | 37 | 7769 | 38564 | 31650974 |
Bradykinesia | 22.83 | 20.90 | 13 | 7793 | 3579 | 31685959 |
Dyspraxia | 22.63 | 20.90 | 7 | 7799 | 412 | 31689126 |
Pain | 22.40 | 20.90 | 9 | 7797 | 186750 | 31502788 |
Hyperthermia | 22.29 | 20.90 | 19 | 7787 | 9985 | 31679553 |
Drug withdrawal syndrome | 21.87 | 20.90 | 25 | 7781 | 18725 | 31670813 |
Hallucination, auditory | 21.72 | 20.90 | 19 | 7787 | 10341 | 31679197 |
Feelings of worthlessness | 20.91 | 20.90 | 6 | 7800 | 272 | 31689266 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Coma | 309.24 | 16.87 | 211 | 15082 | 91633 | 70821518 |
Intentional overdose | 270.91 | 16.87 | 200 | 15093 | 98235 | 70814916 |
Suicide attempt | 263.62 | 16.87 | 181 | 15112 | 79329 | 70833822 |
Serotonin syndrome | 258.12 | 16.87 | 142 | 15151 | 41972 | 70871179 |
Poisoning deliberate | 192.13 | 16.87 | 87 | 15206 | 16973 | 70896178 |
Neuroleptic malignant syndrome | 174.05 | 16.87 | 93 | 15200 | 25914 | 70887237 |
Drug interaction | 159.13 | 16.87 | 290 | 15003 | 381151 | 70532000 |
Overdose | 150.46 | 16.87 | 184 | 15109 | 169561 | 70743590 |
Toxicity to various agents | 149.91 | 16.87 | 283 | 15010 | 381889 | 70531262 |
Sopor | 134.83 | 16.87 | 84 | 15209 | 31183 | 70881968 |
Bezoar | 127.32 | 16.87 | 38 | 15255 | 2268 | 70910883 |
Electrocardiogram QT prolonged | 124.06 | 16.87 | 119 | 15174 | 83398 | 70829753 |
Intentional self-injury | 104.61 | 16.87 | 72 | 15221 | 31578 | 70881573 |
Obsessive-compulsive disorder | 102.90 | 16.87 | 40 | 15253 | 5330 | 70907821 |
Somnolence | 90.97 | 16.87 | 165 | 15128 | 215441 | 70697710 |
Akathisia | 85.15 | 16.87 | 45 | 15248 | 12248 | 70900903 |
Hyperthermia | 74.92 | 16.87 | 46 | 15247 | 16625 | 70896526 |
Depressed level of consciousness | 74.46 | 16.87 | 93 | 15200 | 87338 | 70825813 |
Agitation | 72.71 | 16.87 | 95 | 15198 | 93280 | 70819871 |
Altered state of consciousness | 65.07 | 16.87 | 60 | 15233 | 39962 | 70873189 |
Suicidal ideation | 62.42 | 16.87 | 76 | 15217 | 69520 | 70843631 |
Tremor | 61.67 | 16.87 | 116 | 15177 | 155508 | 70757643 |
Tachycardia | 60.14 | 16.87 | 116 | 15177 | 158430 | 70754721 |
Pain | 59.20 | 16.87 | 31 | 15262 | 628785 | 70284366 |
Mania | 58.94 | 16.87 | 40 | 15253 | 17134 | 70896017 |
Antidepressant drug level increased | 57.24 | 16.87 | 14 | 15279 | 389 | 70912762 |
Antipsychotic drug level increased | 55.76 | 16.87 | 26 | 15267 | 5414 | 70907737 |
Psychomotor hyperactivity | 53.09 | 16.87 | 36 | 15257 | 15397 | 70897754 |
Confusional state | 52.22 | 16.87 | 157 | 15136 | 284241 | 70628910 |
Rhabdomyolysis | 51.86 | 16.87 | 82 | 15211 | 95678 | 70817473 |
Parkinsonism | 48.59 | 16.87 | 34 | 15259 | 15291 | 70897860 |
Diarrhoea | 45.14 | 16.87 | 62 | 15231 | 783279 | 70129872 |
Antipsychotic drug level below therapeutic | 44.86 | 16.87 | 14 | 15279 | 971 | 70912180 |
Fatigue | 44.80 | 16.87 | 68 | 15225 | 824251 | 70088900 |
Shock | 44.38 | 16.87 | 49 | 15244 | 40376 | 70872775 |
Arthralgia | 44.19 | 16.87 | 27 | 15266 | 503363 | 70409788 |
Extrapyramidal disorder | 43.58 | 16.87 | 36 | 15257 | 20714 | 70892437 |
Inappropriate antidiuretic hormone secretion | 41.97 | 16.87 | 37 | 15256 | 23239 | 70889912 |
Myoclonus | 41.84 | 16.87 | 39 | 15254 | 26316 | 70886835 |
Cerebellar syndrome | 41.55 | 16.87 | 21 | 15272 | 5210 | 70907941 |
International normalised ratio abnormal | 41.49 | 16.87 | 21 | 15272 | 5226 | 70907925 |
Hallucination, auditory | 41.02 | 16.87 | 33 | 15260 | 18295 | 70894856 |
Pneumonia aspiration | 40.35 | 16.87 | 58 | 15235 | 62231 | 70850920 |
Drug abuse | 38.82 | 16.87 | 93 | 15200 | 147163 | 70765988 |
Renal hypertension | 38.68 | 16.87 | 9 | 15284 | 201 | 70912950 |
Joint swelling | 37.72 | 16.87 | 5 | 15288 | 253206 | 70659945 |
Psychomotor retardation | 37.37 | 16.87 | 20 | 15273 | 5578 | 70907573 |
Therapeutic product effect variable | 37.29 | 16.87 | 14 | 15279 | 1696 | 70911455 |
Sinus tachycardia | 37.04 | 16.87 | 41 | 15252 | 33872 | 70879279 |
Peripheral swelling | 36.90 | 16.87 | 4 | 15289 | 236559 | 70676592 |
Nasopharyngitis | 36.66 | 16.87 | 3 | 15290 | 222203 | 70690948 |
Disinhibition | 36.64 | 16.87 | 15 | 15278 | 2286 | 70910865 |
Loose associations | 36.51 | 16.87 | 7 | 15286 | 58 | 70913093 |
Muscle rigidity | 36.36 | 16.87 | 31 | 15262 | 18619 | 70894532 |
Polyuria | 36.24 | 16.87 | 27 | 15266 | 13379 | 70899772 |
Euphoric mood | 36.12 | 16.87 | 21 | 15272 | 6868 | 70906283 |
Compartment syndrome | 35.60 | 16.87 | 18 | 15275 | 4468 | 70908683 |
Rheumatoid arthritis | 34.62 | 16.87 | 10 | 15283 | 291795 | 70621356 |
Hypertonia | 34.58 | 16.87 | 20 | 15273 | 6478 | 70906673 |
Apathy | 34.48 | 16.87 | 25 | 15268 | 11883 | 70901268 |
Hepatocellular injury | 34.47 | 16.87 | 46 | 15247 | 46045 | 70867106 |
Hyposmia | 33.11 | 16.87 | 10 | 15283 | 621 | 70912530 |
Livedo reticularis | 32.39 | 16.87 | 16 | 15277 | 3782 | 70909369 |
Hyperchloraemia | 32.35 | 16.87 | 11 | 15282 | 1001 | 70912150 |
Mental disorder | 32.33 | 16.87 | 35 | 15258 | 28205 | 70884946 |
Brachial plexus injury | 32.17 | 16.87 | 7 | 15286 | 114 | 70913037 |
Mydriasis | 31.80 | 16.87 | 27 | 15266 | 16126 | 70897025 |
Bronchial hyperreactivity | 31.48 | 16.87 | 14 | 15279 | 2612 | 70910539 |
Hyperhidrosis | 31.39 | 16.87 | 80 | 15213 | 131506 | 70781645 |
Urinary retention | 31.26 | 16.87 | 47 | 15246 | 52473 | 70860678 |
Bradykinesia | 29.44 | 16.87 | 19 | 15274 | 7483 | 70905668 |
Electrocardiogram QRS complex prolonged | 29.34 | 16.87 | 21 | 15272 | 9785 | 70903366 |
Infusion related reaction | 29.18 | 16.87 | 4 | 15289 | 197530 | 70715621 |
Circulatory collapse | 29.00 | 16.87 | 37 | 15256 | 35437 | 70877714 |
Rash | 28.75 | 16.87 | 41 | 15252 | 510521 | 70402630 |
Miosis | 28.64 | 16.87 | 24 | 15269 | 14077 | 70899074 |
Pressure of speech | 28.25 | 16.87 | 10 | 15283 | 1025 | 70912126 |
Schizoaffective disorder | 28.22 | 16.87 | 12 | 15281 | 2011 | 70911140 |
Ventricular dyskinesia | 28.17 | 16.87 | 8 | 15285 | 400 | 70912751 |
Coma scale abnormal | 28.07 | 16.87 | 19 | 15274 | 8097 | 70905054 |
Restlessness | 26.94 | 16.87 | 39 | 15254 | 42089 | 70871062 |
Seizure | 26.92 | 16.87 | 92 | 15201 | 177870 | 70735281 |
Depression | 26.79 | 16.87 | 99 | 15194 | 198875 | 70714276 |
Loss of consciousness | 26.69 | 16.87 | 84 | 15209 | 155632 | 70757519 |
Retroplacental haematoma | 26.61 | 16.87 | 6 | 15287 | 116 | 70913035 |
Prescribed overdose | 26.52 | 16.87 | 31 | 15262 | 27150 | 70886001 |
Abdominal pain | 26.47 | 16.87 | 21 | 15272 | 342106 | 70571045 |
Disturbance in attention | 26.40 | 16.87 | 39 | 15254 | 42855 | 70870296 |
Intentional product misuse | 26.27 | 16.87 | 55 | 15238 | 79540 | 70833611 |
Febrile neutropenia | 26.14 | 16.87 | 6 | 15287 | 204312 | 70708839 |
Asphyxia | 26.12 | 16.87 | 20 | 15273 | 10322 | 70902829 |
Anxiety | 25.89 | 16.87 | 105 | 15188 | 220225 | 70692926 |
Poisoning | 25.83 | 16.87 | 28 | 15265 | 22594 | 70890557 |
Nausea | 25.66 | 16.87 | 96 | 15197 | 851992 | 70061159 |
Speech disorder | 25.57 | 16.87 | 42 | 15251 | 50538 | 70862613 |
Breast disorder | 25.34 | 16.87 | 11 | 15282 | 1938 | 70911213 |
Drug level increased | 25.15 | 16.87 | 35 | 15258 | 36434 | 70876717 |
Hypotension | 25.11 | 16.87 | 161 | 15132 | 404220 | 70508931 |
Post-anoxic myoclonus | 24.80 | 16.87 | 5 | 15288 | 55 | 70913096 |
Product dose omission issue | 24.79 | 16.87 | 8 | 15285 | 217460 | 70695691 |
Hypothermia | 24.41 | 16.87 | 26 | 15267 | 20568 | 70892583 |
Generalised tonic-clonic seizure | 24.39 | 16.87 | 37 | 15256 | 41624 | 70871527 |
Cor pulmonale acute | 24.37 | 16.87 | 8 | 15285 | 653 | 70912498 |
Otorrhoea | 23.91 | 16.87 | 10 | 15283 | 1608 | 70911543 |
Blood prolactin increased | 23.91 | 16.87 | 13 | 15280 | 3741 | 70909410 |
Withdrawal syndrome | 23.63 | 16.87 | 28 | 15265 | 24876 | 70888275 |
Pain in extremity | 23.12 | 16.87 | 22 | 15271 | 328060 | 70585091 |
Cough | 22.72 | 16.87 | 22 | 15271 | 325355 | 70587796 |
Psychomotor skills impaired | 22.31 | 16.87 | 13 | 15280 | 4271 | 70908880 |
Pneumonia | 22.23 | 16.87 | 61 | 15232 | 596171 | 70316980 |
Onychophagia | 22.06 | 16.87 | 5 | 15288 | 99 | 70913052 |
Obesity | 22.01 | 16.87 | 28 | 15265 | 26743 | 70886408 |
Psychiatric symptom | 21.67 | 16.87 | 15 | 15278 | 6629 | 70906522 |
Abulia | 21.65 | 16.87 | 8 | 15285 | 927 | 70912224 |
Urine osmolarity increased | 21.61 | 16.87 | 6 | 15287 | 276 | 70912875 |
Aggression | 21.54 | 16.87 | 38 | 15255 | 48408 | 70864743 |
Dyspraxia | 21.53 | 16.87 | 6 | 15287 | 280 | 70912871 |
Alopecia | 21.42 | 16.87 | 8 | 15285 | 198482 | 70714669 |
Paralogism | 20.99 | 16.87 | 4 | 15289 | 32 | 70913119 |
Cataplexy | 20.98 | 16.87 | 8 | 15285 | 1011 | 70912140 |
Heat stroke | 20.90 | 16.87 | 9 | 15284 | 1554 | 70911597 |
Therapeutic product effect decreased | 20.87 | 16.87 | 3 | 15290 | 143015 | 70770136 |
Pleurothotonus | 20.27 | 16.87 | 10 | 15283 | 2356 | 70910795 |
Clonus | 20.09 | 16.87 | 14 | 15279 | 6254 | 70906897 |
Arthropathy | 20.02 | 16.87 | 4 | 15289 | 150053 | 70763098 |
Hypokalaemia | 19.98 | 16.87 | 68 | 15225 | 131120 | 70782031 |
Morbid thoughts | 19.48 | 16.87 | 7 | 15286 | 749 | 70912402 |
Nephrogenic diabetes insipidus | 18.94 | 16.87 | 9 | 15284 | 1954 | 70911197 |
Hypernatraemia | 18.57 | 16.87 | 18 | 15275 | 12743 | 70900408 |
Obsessive-compulsive symptom | 18.57 | 16.87 | 5 | 15288 | 205 | 70912946 |
Dyslipidaemia | 18.43 | 16.87 | 16 | 15277 | 9844 | 70903307 |
Product use in unapproved indication | 18.43 | 16.87 | 91 | 15202 | 207387 | 70705764 |
Headache | 18.35 | 16.87 | 64 | 15229 | 580341 | 70332810 |
Social anxiety disorder | 18.28 | 16.87 | 6 | 15287 | 489 | 70912662 |
Major depression | 18.26 | 16.87 | 15 | 15278 | 8559 | 70904592 |
Spasmodic dysphonia | 18.25 | 16.87 | 5 | 15288 | 219 | 70912932 |
Feelings of worthlessness | 18.21 | 16.87 | 6 | 15287 | 495 | 70912656 |
Anticholinergic syndrome | 18.10 | 16.87 | 10 | 15283 | 2970 | 70910181 |
Stomatitis | 18.06 | 16.87 | 3 | 15290 | 128508 | 70784643 |
Hyperreflexia | 17.94 | 16.87 | 14 | 15279 | 7428 | 70905723 |
Disorientation | 17.92 | 16.87 | 39 | 15254 | 57884 | 70855267 |
Hypersensitivity | 17.90 | 16.87 | 14 | 15279 | 229798 | 70683353 |
Sepsis | 17.69 | 16.87 | 16 | 15277 | 244529 | 70668622 |
Completed suicide | 17.66 | 16.87 | 96 | 15197 | 227039 | 70686112 |
Blood creatine phosphokinase increased | 17.55 | 16.87 | 40 | 15253 | 61223 | 70851928 |
Increased appetite | 17.41 | 16.87 | 16 | 15277 | 10597 | 70902554 |
Drug screen false positive | 17.36 | 16.87 | 7 | 15286 | 1026 | 70912125 |
Stupor | 17.35 | 16.87 | 13 | 15280 | 6496 | 70906655 |
Hepatic cytolysis | 17.26 | 16.87 | 21 | 15272 | 19171 | 70893980 |
Right ventricular dilatation | 17.19 | 16.87 | 8 | 15285 | 1657 | 70911494 |
Hypovolaemic shock | 17.13 | 16.87 | 16 | 15277 | 10821 | 70902330 |
Contraindicated product administered | 17.12 | 16.87 | 4 | 15289 | 134608 | 70778543 |
Irritability | 17.02 | 16.87 | 30 | 15263 | 38195 | 70874956 |
Hyponatraemia | 17.00 | 16.87 | 74 | 15219 | 160013 | 70753138 |
Death | 16.96 | 16.87 | 55 | 15238 | 510006 | 70403145 |
None
Source | Code | Description |
---|---|---|
ATC | N06AA04 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Non-selective monoamine reuptake inhibitors |
CHEBI has role | CHEBI:35469 | antidepressants |
CHEBI has role | CHEBI:48278 | serotonergic drugs |
CHEBI has role | CHEBI:48279 | serotonin antagonists |
CHEBI has role | CHEBI:149553 | anticoronaviral drug |
MeSH PA | D000928 | Antidepressive Agents |
MeSH PA | D000929 | Antidepressive Agents, Tricyclic |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D018490 | Serotonin Agents |
MeSH PA | D017367 | Serotonin Uptake Inhibitors |
FDA EPC | N0000175752 | Tricyclic Antidepressant |
CHEBI has role | CHEBI:50949 | SSRI |
CHEBI has role | CHEBI:77402 | EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Obsessive-compulsive disorder | indication | 191736004 | DOID:10933 |
Depressive disorder | off-label use | 35489007 | |
Cataplexy | off-label use | 46263000 | |
Anxiety | off-label use | 48694002 | |
Panic disorder | off-label use | 371631005 | DOID:594 |
Suicidal thoughts | contraindication | 6471006 | |
Alcoholism | contraindication | 7200002 | |
Glaucoma | contraindication | 23986001 | DOID:1686 |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Acute nephropathy | contraindication | 58574008 | |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Bipolar affective disorder, current episode manic | contraindication | 191618007 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Retention of urine | contraindication | 267064002 | |
Pheochromocytoma | contraindication | 302835009 | |
Malignant hyperthermia | contraindication | 405501007 | |
Myocardial infarction in recovery phase | contraindication | 418044006 | |
Neuroblastoma | contraindication | 432328008 | DOID:769 |
Atrioventricular Conduction Defect | contraindication |
Species | Use | Relation |
---|---|---|
Dogs | Separation anxiety | Indication |
Product | Applicant | Ingredients |
---|---|---|
Clomicalm Tablets | Virbac AH Inc. | 1 |
Clomipramine Hydrochloride Tablets | Mizner Bioscience LLC | 1 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.04 | Basic |
pKa2 | 6.19 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium-dependent noradrenaline transporter | Transporter | INHIBITOR | Kd | 7.42 | WOMBAT-PK | IUPHAR | |||
Sodium-dependent serotonin transporter | Transporter | INHIBITOR | Ki | 9.70 | PDSP | CHEMBL | |||
Alpha-2A adrenergic receptor | GPCR | Ki | 6.28 | PDSP | |||||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 6.24 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 2A | GPCR | Ki | 7.45 | PDSP | |||||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 6.82 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 7.19 | PDSP | |||||
5-hydroxytryptamine receptor 6 | GPCR | Ki | 6.95 | CHEMBL | |||||
Alpha-1A adrenergic receptor | GPCR | Ki | 8.50 | WOMBAT-PK | |||||
Alpha-2B adrenergic receptor | GPCR | Ki | 7.34 | DRUG MATRIX | |||||
D(3) dopamine receptor | GPCR | Ki | 7.41 | PDSP | |||||
Histamine H1 receptor | GPCR | Ki | 8.01 | DRUG MATRIX | |||||
Histamine H2 receptor | GPCR | Ki | 5.70 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M1 | GPCR | Ki | 7.66 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M2 | GPCR | Ki | 7.07 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M3 | GPCR | Ki | 7.44 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M4 | GPCR | Ki | 7.89 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M5 | GPCR | Ki | 7.42 | DRUG MATRIX | |||||
Aldehyde oxidase | Enzyme | IC50 | 6.32 | WOMBAT-PK | |||||
Alpha-2C adrenergic receptor | GPCR | Ki | 6.69 | DRUG MATRIX | |||||
Sodium-dependent dopamine transporter | Transporter | IC50 | 5.56 | CHEMBL | |||||
Cytochrome P450 2D6 | Enzyme | Ki | 5.66 | WOMBAT-PK | |||||
Alpha-1D adrenergic receptor | GPCR | Ki | 7.40 | DRUG MATRIX | |||||
Glutathione S-transferase P | Enzyme | WOMBAT-PK | |||||||
Solute carrier family 22 member 1 | Transporter | IC50 | 4.71 | CHEMBL | |||||
D(1A) dopamine receptor | GPCR | Ki | 6.66 | PDSP | |||||
D(2) dopamine receptor | GPCR | Ki | 6.95 | PDSP | |||||
Trypanothione reductase | Enzyme | Ki | 5.19 | CHEMBL | |||||
Alpha-1B adrenergic receptor | GPCR | Ki | 7.14 | DRUG MATRIX | |||||
Membrane-associated progesterone receptor component 1 | Membrane receptor | Ki | 5.94 | DRUG MATRIX | |||||
Alpha-1A adrenergic receptor | GPCR | IC50 | 10.40 | CHEMBL | |||||
D(2) dopamine receptor | GPCR | Ki | 7.25 | CHEMBL | |||||
Sodium-dependent noradrenaline transporter | Transporter | IC50 | 6.05 | CHEMBL | |||||
Sodium-dependent serotonin transporter | Transporter | IC50 | 7.15 | CHEMBL | |||||
Histamine H1 receptor | GPCR | IC50 | 9.70 | CHEMBL | |||||
Serotonin (5-HT) receptor | GPCR | IC50 | 8.30 | CHEMBL | |||||
Serotonin 1 (5-HT1) receptor | GPCR | Ki | 5.30 | CHEMBL | |||||
Adrenergic receptor alpha-2 | GPCR | Ki | 7.29 | CHEMBL | |||||
Serotonin 2 (5-HT2) receptor | GPCR | Ki | 8.08 | CHEMBL | |||||
Trypanothione reductase | Enzyme | IC50 | 5.47 | CHEMBL | |||||
G protein-activated inward rectifier potassium channel 2 | Ion channel | BLOCKER | IC50 | 4.40 | IUPHAR |
ID | Source |
---|---|
4019687 | VUID |
N0000147779 | NUI |
D00811 | KEGG_DRUG |
17321-77-6 | SECONDARY_CAS_RN |
2597 | RXNORM |
4019492 | VANDF |
4019687 | VANDF |
C0009010 | UMLSCUI |
CHEBI:47780 | CHEBI |
CXX | PDB_CHEM_ID |
CHEMBL415 | ChEMBL_ID |
CHEMBL1200710 | ChEMBL_ID |
DB01242 | DRUGBANK_ID |
D002997 | MESH_DESCRIPTOR_UI |
2801 | PUBCHEM_CID |
2398 | IUPHAR_LIGAND_ID |
2238 | INN_ID |
NUV44L116D | UNII |
373 | MMSL |
4476 | MMSL |
d00876 | MMSL |
003456 | NDDF |
004614 | NDDF |
372903001 | SNOMEDCT_US |
387027004 | SNOMEDCT_US |
96209002 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Clomipramine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3025 | CAPSULE | 25 mg | ORAL | ANDA | 25 sections |
Clomipramine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3050 | CAPSULE | 50 mg | ORAL | ANDA | 25 sections |
Clomipramine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3075 | CAPSULE | 75 mg | ORAL | ANDA | 25 sections |
CLOMIPRAMINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0406-8806 | CAPSULE | 25 mg | ORAL | NDA | 24 sections |
CLOMIPRAMINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0406-8807 | CAPSULE | 50 mg | ORAL | NDA | 24 sections |
CLOMIPRAMINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0406-8808 | CAPSULE | 75 mg | ORAL | NDA | 24 sections |
ANAFRANIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0406-9906 | CAPSULE | 25 mg | ORAL | NDA | 24 sections |
ANAFRANIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0406-9907 | CAPSULE | 50 mg | ORAL | NDA | 24 sections |
ANAFRANIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0406-9908 | CAPSULE | 75 mg | ORAL | NDA | 24 sections |
Clomipramine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-2027 | CAPSULE | 25 mg | ORAL | ANDA | 25 sections |
Clomipramine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-2037 | CAPSULE | 50 mg | ORAL | ANDA | 25 sections |
Clomipramine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-0630 | CAPSULE | 25 mg | ORAL | ANDA | 24 sections |
Clomipramine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-0631 | CAPSULE | 50 mg | ORAL | ANDA | 24 sections |
Clomipramine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-0632 | CAPSULE | 75 mg | ORAL | ANDA | 24 sections |
CLOMIPRAMINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7038 | CAPSULE | 25 mg | ORAL | ANDA | 26 sections |
CLOMIPRAMINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7039 | CAPSULE | 50 mg | ORAL | ANDA | 26 sections |
clomiPRAMINE Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10135-698 | CAPSULE | 25 mg | ORAL | ANDA | 27 sections |
clomiPRAMINE Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10135-699 | CAPSULE | 50 mg | ORAL | ANDA | 27 sections |
clomiPRAMINE Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10135-700 | CAPSULE | 75 mg | ORAL | ANDA | 27 sections |
Clomipramine Hydrochloride | Human Prescription Drug Label | 1 | 16571-683 | CAPSULE | 25 mg | ORAL | ANDA | 23 sections |
Clomipramine Hydrochloride | Human Prescription Drug Label | 1 | 16571-684 | CAPSULE | 50 mg | ORAL | ANDA | 23 sections |
Clomipramine Hydrochloride | Human Prescription Drug Label | 1 | 16571-685 | CAPSULE | 75 mg | ORAL | ANDA | 23 sections |
Clomipramine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-849 | CAPSULE | 25 mg | ORAL | ANDA | 21 sections |
Clomipramine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-850 | CAPSULE | 50 mg | ORAL | ANDA | 21 sections |
Clomipramine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-851 | CAPSULE | 75 mg | ORAL | ANDA | 21 sections |
Clomipramine hydrochloride | Human Prescription Drug Label | 1 | 27241-210 | CAPSULE | 25 mg | ORAL | ANDA | 23 sections |
Clomipramine hydrochloride | Human Prescription Drug Label | 1 | 27241-211 | CAPSULE | 50 mg | ORAL | ANDA | 23 sections |
Clomipramine hydrochloride | Human Prescription Drug Label | 1 | 27241-212 | CAPSULE | 75 mg | ORAL | ANDA | 23 sections |
CLOMIPRAMINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42571-342 | CAPSULE | 25 mg | ORAL | ANDA | 23 sections |
CLOMIPRAMINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42571-343 | CAPSULE | 50 mg | ORAL | ANDA | 23 sections |