iprindole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	1478	5560-72-5

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: iprindole pramindole	A tricyclic antidepressant that has actions and uses similar to those of AMITRIPTYLINE, but has only weak antimuscarinic and sedative effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p257) Molecular weight: 284.45 Formula: C19H28N2 CLOGP: 5.66 LIPINSKI: 1 HAC: 2 HDO: 0 TPSA: 8.17 ALOGS: -4.28 ROTB: 4

Molecule

Description

Molfile Inchi Smiles

Synonyms:

iprindole
pramindole

A tricyclic antidepressant that has actions and uses similar to those of AMITRIPTYLINE, but has only weak antimuscarinic and sedative effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p257)

Molecular weight: 284.45
Formula: C19H28N2
CLOGP: 5.66
LIPINSKI: 1
HAC: 2
HDO: 0
TPSA: 8.17
ALOGS: -4.28
ROTB: 4

Drug dosage:

Dose	Unit	Route
90	mg	O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N06AA13	NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Non-selective monoamine reuptake inhibitors
MeSH PA	D000928	Antidepressive Agents
MeSH PA	D000929	Antidepressive Agents, Tricyclic
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D011619	Psychotropic Drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.16	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Type	Activity value (-log[M])	Bioact source
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN	Ki	5.79	PDSP
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN	Ki	5.90	PDSP
Histamine H1 receptor	GPCR	P35367	HRH1_HUMAN	Ki	6.92	PDSP
Sodium-dependent dopamine transporter	Transporter	Q01959	SC6A3_HUMAN	Ki	5.19	PDSP

External reference:

ID	Source
N0000166960	NUI
D04605	KEGG_DRUG
C0022057	UMLSCUI
CHEBI:135177	CHEBI
CHEMBL126224	ChEMBL_ID
DB13496	DRUGBANK_ID
D007488	MESH_DESCRIPTOR_UI
21722	PUBCHEM_CID
1854	INN_ID
69U0IKR8FP	UNII
5979	RXNORM
003982	NDDF
321826008	SNOMEDCT_US
419144003	SNOMEDCT_US

Pharmaceutical products:

None