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dibenzepin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| tricyclic compounds | 856 | 4498-32-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.30 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 25 % |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK1,JAK2,KIT,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK10,MAPK12,MAPK7,MAPK9,MARK4,MELK,MET,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ULK2 | 57 | |||
| kinase-selectivity-class | ACVR2B,AXL,CAMK2D,MAPK7,PDK4,SIK2,STK33,TTK | 8 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N06AA08 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Non-selective monoamine reuptake inhibitors |
| MeSH PA | D000928 | Antidepressive Agents |
| MeSH PA | D000929 | Antidepressive Agents, Tricyclic |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D011619 | Psychotropic Drugs |
Related Drugs by ATC class:
N06AA Non-selective monoamine reuptake inhibitors 20 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.1 | Basic |
| pKa2 | 6.19 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | GPCR | Ki | 5.60 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 2A | GPCR | Ki | 5.14 | CHEMBL | |||||
| D(2) dopamine receptor | GPCR | Ki | 4.52 | CHEMBL | |||||
| Sodium-dependent serotonin transporter | Transporter | Ki | 4.96 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 6 | GPCR | Ki | 5.48 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 7 | GPCR | Ki | 4.91 | CHEMBL | |||||
| Histamine H1 receptor | GPCR | Ki | 7.70 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D01314 | KEGG_DRUG |
| 236807 | RXNORM |
| C0012029 | UMLSCUI |
| CHEBI:93394 | CHEBI |
| CHEMBL1442422 | ChEMBL_ID |
| DB13225 | DRUGBANK_ID |
| CHEMBL2104287 | ChEMBL_ID |
| C084605 | MESH_SUPPLEMENTAL_RECORD_UI |
| 9419 | PUBCHEM_CID |
| 1738 | INN_ID |
| 315-80-0 | SECONDARY_CAS_RN |
| 510SJZ1Y6L | UNII |
| 006897 | NDDF |
| 006898 | NDDF |
| 32757009 | SNOMEDCT_US |
| CHEMBL99486 | ChEMBL_ID |
| 510SJZ1Y6L | INXIGHT DRUGS |
Pharmaceutical products:
None