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butriptyline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antidepressants, dibenzo[a,d]cycloheptane or cyclopheptene derivatives | 455 | 35941-65-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
a tricyclic antianxiety and antidepressive agent similar to, but with less side effects than amitriptyline; minor descriptor (75-86); on line & INDEX MEDICUS search DIBENZOCYCLOHEPTENES (75-86); RN given refers to parent cpd
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 75 | mg | O |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AKT1,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP3K7,MAPK10,MAPK12,MAPK7,MET,NTRK2,PDK2,PDK4,PDPK1,PIM2,PRKDC,SIK2,SIK3,TEK,TGFBR1 | 38 | |||
| kinase-selectivity-class | AXL,EIF2AK3,EPHB4,PDK4 | 4 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N06AA15 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Non-selective monoamine reuptake inhibitors |
| MeSH PA | D000928 | Antidepressive Agents |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D011619 | Psychotropic Drugs |
| MeSH PA | D014149 | Tranquilizing Agents |
| MeSH PA | D014151 | Anti-Anxiety Agents |
| CHEBI has role | CHEBI:35469 | antidepressant |
Related Drugs by ATC class:
N06AA Non-selective monoamine reuptake inhibitors 20 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Depressive disorder | indication | 35489007 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.19 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sodium-dependent serotonin transporter | Transporter | Ki | 5.87 | PDSP | |||||
| Sodium-dependent noradrenaline transporter | Transporter | Ki | 5.29 | PDSP | |||||
| Sodium-dependent dopamine transporter | Transporter | Ki | 5.41 | PDSP |
External reference:
| ID | Source |
|---|---|
| D03199 | KEGG_DRUG |
| 5585-73-9 | SECONDARY_CAS_RN |
| 19895 | RXNORM |
| C0054270 | UMLSCUI |
| CHEBI:135227 | CHEBI |
| CHEMBL2110816 | ChEMBL_ID |
| CHEMBL2106170 | ChEMBL_ID |
| DB09016 | DRUGBANK_ID |
| C100242 | MESH_SUPPLEMENTAL_RECORD_UI |
| 21772 | PUBCHEM_CID |
| 2123 | INN_ID |
| Z22441975X | UNII |
| 115544001 | SNOMEDCT_US |
| 386997004 | SNOMEDCT_US |
| 003938 | NDDF |
| 003939 | NDDF |
Pharmaceutical products:
None