amitriptyline Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antidepressants, dibenzo[a,d]cycloheptane or cyclopheptene derivatives 180 50-48-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • amitriptyline
  • amitriprolidine
  • amitriptylin
  • damitriptyline
  • amitriptyline hydrochloride
  • amitryptiline
  • amitryptiline hydrochloride
  • amitriptyline HCl
  • amitryptiline HCl
Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
  • Molecular weight: 277.41
  • Formula: C20H23N
  • CLOGP: 4.85
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA: 3.24
  • ALOGS: -4.79
  • ROTB: 3

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
75 mg O
75 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1000 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 15.45 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 48 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 8.70 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 6.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.07 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 17 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
April 7, 1961 FDA ASTRAZENECA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 592.19 9.62 1239 122652 144681 46417490
Toxicity to various agents 516.61 9.62 1478 122413 210288 46351883
Drug abuse 266.71 9.62 547 123344 62861 46499310
Respiratory arrest 191.00 9.62 331 123560 33485 46528686
Coma 179.96 9.62 445 123446 57904 46504267
Electrocardiogram QRS complex prolonged 176.64 9.62 133 123758 5316 46556855
Overdose 172.65 9.62 629 123262 101350 46460821
Serotonin syndrome 136.66 9.62 237 123654 23983 46538188
Poisoning deliberate 110.04 9.62 120 123771 7806 46554365
Intentional overdose 107.66 9.62 398 123493 64546 46497625
Pemphigus 106.13 9.62 3 123888 45271 46516900
Cardiac arrest 105.91 9.62 498 123393 89901 46472270
Anticholinergic syndrome 98.98 9.62 61 123830 1745 46560426
Sedation complication 98.71 9.62 80 123811 3565 46558606
Cardio-respiratory arrest 98.48 9.62 366 123525 59503 46502668
Cognitive disorder 92.98 9.62 261 123630 36622 46525549
Suicidal ideation 92.17 9.62 344 123547 56038 46506133
Systemic lupus erythematosus 88.76 9.62 31 123860 65149 46497022
Depressed level of consciousness 88.67 9.62 303 123588 47266 46514905
Sedation 87.37 9.62 190 123701 22720 46539451
Confusional state 86.46 9.62 722 123169 159170 46403001
Fibromyalgia 79.46 9.62 245 123646 36218 46525953
Anaemia 78.11 9.62 381 123510 255398 46306773
Neutropenia 76.72 9.62 166 123725 143038 46419133
Migraine 75.67 9.62 377 123514 69649 46492522
Poisoning 75.13 9.62 134 123757 13860 46548311
Febrile neutropenia 72.00 9.62 87 123804 94540 46467631
Mydriasis 69.90 9.62 111 123780 10442 46551729
Orthostatic hypotension 67.63 9.62 180 123711 24478 46537693
Suicide attempt 66.48 9.62 306 123585 54730 46507441
Somnolence 64.54 9.62 667 123224 155854 46406317
Withdrawal syndrome 64.20 9.62 146 123745 17988 46544183
Agitation 61.04 9.62 300 123591 55115 46507056
Drug withdrawal syndrome 60.59 9.62 185 123706 27199 46534972
Creatinine renal clearance decreased 60.58 9.62 83 123808 6837 46555334
Glossodynia 58.88 9.62 22 123869 44351 46517820
Platelet count decreased 58.63 9.62 110 123781 99914 46462257
Alopecia 57.98 9.62 228 123663 162186 46399985
Balance disorder 57.85 9.62 330 123561 64191 46497980
Drug interaction 57.62 9.62 806 123085 202288 46359883
Off label use 56.11 9.62 692 123199 379149 46183022
Abdominal discomfort 56.03 9.62 209 123682 150956 46411215
Disease progression 54.76 9.62 99 123792 91201 46470970
Impaired work ability 54.23 9.62 110 123781 12526 46549645
Hand deformity 51.45 9.62 14 123877 34560 46527611
Disturbance in attention 51.09 9.62 192 123699 31368 46530803
Electrocardiogram QT prolonged 50.35 9.62 269 123622 51056 46511115
Synovial fluid analysis 49.97 9.62 36 123855 1343 46560828
Somatic symptom disorder 49.75 9.62 41 123850 1871 46560300
Tenosynovitis stenosans 49.06 9.62 41 123850 1908 46560263
Diarrhoea 49.04 9.62 1122 122769 558480 46003691
Exposure during pregnancy 48.87 9.62 137 123754 108075 46454096
Derealisation 48.85 9.62 29 123862 774 46561397
Depressed mood 47.69 9.62 195 123696 33124 46529047
Bradypnoea 47.48 9.62 49 123842 2990 46559181
Respiratory depression 47.45 9.62 99 123792 11501 46550670
Thrombocytopenia 46.25 9.62 176 123715 126405 46435766
Contraindicated product administered 45.04 9.62 90 123801 79857 46482314
Anxiety 44.88 9.62 705 123186 181252 46380919
Hallucination, visual 44.56 9.62 126 123765 17747 46544424
Blood calcium decreased 43.57 9.62 115 123776 15558 46546613
Device expulsion 43.21 9.62 10 123881 27532 46534639
Nightmare 42.35 9.62 118 123773 16480 46545691
Scleritis 42.02 9.62 45 123846 2867 46559304
Bursitis 41.99 9.62 132 123759 19710 46542461
Sacroiliitis 41.38 9.62 39 123852 2130 46560041
Atrial fibrillation 41.19 9.62 139 123752 103451 46458720
Crystal nephropathy 40.53 9.62 26 123865 799 46561372
Maternal exposure during pregnancy 40.50 9.62 138 123753 102411 46459760
Dystonia 40.25 9.62 91 123800 11166 46551005
Hallucinations, mixed 39.63 9.62 50 123841 3799 46558372
Peritonitis 37.99 9.62 5 123886 20709 46541462
Feeling jittery 37.17 9.62 87 123804 10921 46551250
Hyperhidrosis 36.96 9.62 381 123510 88927 46473244
Delirium 36.43 9.62 195 123696 37033 46525138
Dissociation 36.29 9.62 34 123857 1843 46560328
Rheumatoid arthritis 35.63 9.62 437 123454 239778 46322393
Psychotic disorder due to a general medical condition 35.58 9.62 15 123876 186 46561985
Pulmonary eosinophilia 35.53 9.62 16 123875 235 46561936
Loss of consciousness 35.41 9.62 441 123450 107797 46454374
Gastric pH decreased 35.25 9.62 18 123873 354 46561817
Coma scale abnormal 35.02 9.62 54 123837 4952 46557219
Depression 34.63 9.62 639 123252 169465 46392706
Autonomic dysreflexia 34.15 9.62 15 123876 207 46561964
Emotional disorder 33.83 9.62 90 123801 12234 46549937
Myoclonus 33.67 9.62 99 123792 14253 46547918
Feeling of despair 33.57 9.62 32 123859 1773 46560398
Arthropathy 32.75 9.62 115 123776 84585 46477586
Restless legs syndrome 32.25 9.62 104 123787 15739 46546432
Hypersensitivity 32.18 9.62 250 123641 150071 46412100
Foetal exposure during pregnancy 32.11 9.62 21 123870 30726 46531445
Speech disorder 31.76 9.62 184 123707 35983 46526188
White blood cell count decreased 31.46 9.62 172 123719 112059 46450112
Rubber sensitivity 31.41 9.62 30 123861 1666 46560505
Septic shock 31.06 9.62 67 123824 57826 46504345
Crepitations 31 9.62 57 123834 6035 46556136
Cogwheel rigidity 30.77 9.62 28 123863 1462 46560709
Dry mouth 30.68 9.62 250 123641 54676 46507495
Brain injury 30.61 9.62 57 123834 6093 46556078
Cestode infection 30.47 9.62 15 123876 272 46561899
Hospitalisation 30.30 9.62 78 123813 63307 46498864
Pleuritic pain 30.12 9.62 58 123833 6358 46555813
Tachycardia 30.09 9.62 400 123491 99222 46462949
Circulatory collapse 29.72 9.62 125 123766 21499 46540672
Drug ineffective for unapproved indication 29.22 9.62 103 123788 16310 46545861
Product dose omission issue 29.15 9.62 296 123595 168224 46393947
Fall 29.02 9.62 1107 122784 327990 46234181
Product use issue 28.80 9.62 141 123750 94503 46467668
Swollen tongue 28.52 9.62 153 123738 29079 46533092
Impaired reasoning 27.77 9.62 9 123882 49 46562122
Multiple sclerosis relapse 27.58 9.62 199 123692 41926 46520245
Sinus tachycardia 27.35 9.62 122 123769 21527 46540644
Lip pruritus 27.19 9.62 17 123874 499 46561672
Insomnia 27.06 9.62 600 123291 164324 46397847
Leukopenia 26.95 9.62 92 123799 68251 46493920
Respiratory rate decreased 26.77 9.62 37 123854 3073 46559098
Magnesium deficiency 26.65 9.62 16 123875 436 46561735
Neuralgia 26.63 9.62 120 123771 21263 46540908
Tremor 26.59 9.62 443 123448 115196 46446975
Dependence 26.39 9.62 29 123862 1902 46560269
Bone marrow failure 26.23 9.62 24 123867 29645 46532526
Dysarthria 26.22 9.62 180 123711 37318 46524853
Akathisia 26.08 9.62 61 123830 7653 46554518
Plasma cell myeloma 25.97 9.62 49 123842 44429 46517742
Oedema 25.97 9.62 91 123800 66980 46495191
C-reactive protein abnormal 25.87 9.62 12 123879 21258 46540913
Amnesia 25.74 9.62 194 123697 41437 46520734
Medication overuse headache 25.70 9.62 16 123875 466 46561705
Photophobia 25.66 9.62 91 123800 14453 46547718
Paraesthesia 25.59 9.62 446 123445 116991 46445180
Intentional product misuse 25.51 9.62 213 123678 46915 46515256
Pericarditis 25.45 9.62 16 123875 23911 46538260
Hepatic enzyme increased 25.38 9.62 121 123770 81666 46480505
Multiple organ dysfunction syndrome 25.20 9.62 63 123828 51647 46510524
Malignant neoplasm progression 25.20 9.62 88 123803 64838 46497333
Cervix neoplasm 25.12 9.62 12 123879 203 46561968
Ventricular tachycardia 24.83 9.62 100 123791 16867 46545304
Eyelid exfoliation 24.32 9.62 10 123881 116 46562055
Tubulointerstitial nephritis and uveitis syndrome 24.32 9.62 10 123881 116 46562055
Sopor 23.75 9.62 110 123781 19718 46542453
Muscle twitching 23.53 9.62 89 123802 14583 46547588
Pulseless electrical activity 23.50 9.62 56 123835 7111 46555060
Wound 23.41 9.62 49 123842 42753 46519418
Haemoglobin decreased 23.33 9.62 224 123667 128725 46433446
Eye pain 23.15 9.62 140 123751 27800 46534371
Depersonalisation/derealisation disorder 22.88 9.62 20 123871 990 46561181
Haemorrhage 22.23 9.62 73 123818 54796 46507375
Body tinea 22.16 9.62 19 123872 916 46561255
Hallucination 22.05 9.62 216 123675 49735 46512436
Pulmonary arterial hypertension 21.73 9.62 22 123869 25906 46536265
Diet failure 21.62 9.62 7 123884 38 46562133
Diaphragmatic rupture 21.60 9.62 11 123880 215 46561956
Cardiac failure 21.60 9.62 124 123767 79824 46482347
H1N1 influenza 21.53 9.62 23 123868 1461 46560710
Tenderness 21.22 9.62 95 123796 16786 46545385
Restlessness 21.21 9.62 128 123763 25396 46536775
Dehydration 21.14 9.62 297 123594 159243 46402928
Neutrophil count decreased 21.09 9.62 53 123838 43373 46518798
Judgement impaired 21.00 9.62 16 123875 651 46561520
Injection site erythema 20.88 9.62 114 123777 74313 46487858
Premenstrual syndrome 20.87 9.62 16 123875 657 46561514
Muscle spasms 20.85 9.62 450 123441 122663 46439508
Pituitary tumour benign 20.85 9.62 24 123867 1657 46560514
Clear cell renal cell carcinoma 20.75 9.62 19 123872 1000 46561171
Drug dependence 20.67 9.62 106 123785 19795 46542376
Cardiac death 20.62 9.62 15 123876 568 46561603
Cushingoid 20.59 9.62 49 123842 6217 46555954
Psychotic symptom 20.57 9.62 18 123873 892 46561279
Cerebellar stroke 20.53 9.62 10 123881 177 46561994
CYP3A4 polymorphism 20.51 9.62 8 123883 80 46562091
Palpitations 20.47 9.62 361 123530 94898 46467273
Synovitis 20.35 9.62 88 123803 60987 46501184
Pancytopenia 20.35 9.62 137 123754 84921 46477250
Renal impairment 20.28 9.62 115 123776 74257 46487914
Myofascial pain syndrome 19.85 9.62 25 123866 1896 46560275
Dyskinesia 19.72 9.62 138 123753 28787 46533384
Pyrexia 19.25 9.62 744 123147 348058 46214113
Enthesopathy 19.15 9.62 40 123851 4650 46557521
Unevaluable event 19.00 9.62 61 123830 46114 46516057
Vestibular migraine 18.99 9.62 8 123883 99 46562072
Accidental overdose 18.88 9.62 104 123787 19962 46542209
Musculoskeletal stiffness 18.84 9.62 365 123526 97628 46464543
Sepsis 18.81 9.62 251 123640 135763 46426408
Sleep disorder 18.58 9.62 198 123693 46597 46515574
Tension 18.58 9.62 30 123861 2862 46559309
Sensory loss 18.53 9.62 50 123841 6852 46555319
Cardiac failure congestive 18.06 9.62 156 123735 91594 46470577
Viral diarrhoea 18.05 9.62 8 123883 113 46562058
Parosmia 17.86 9.62 36 123855 4080 46558091
Infusion related reaction 17.80 9.62 177 123714 101031 46461140
Subclavian artery embolism 17.78 9.62 5 123886 15 46562156
Tearfulness 17.75 9.62 36 123855 4099 46558072
Knee arthroplasty 17.73 9.62 22 123869 23643 46538528
Hypoglycaemic seizure 17.58 9.62 13 123878 505 46561666
Synovial cyst 17.55 9.62 51 123840 7295 46554876
Rectal cancer metastatic 17.43 9.62 10 123881 250 46561921
Peripheral circulatory failure 17.41 9.62 11 123880 329 46561842
Drug ineffective 17.27 9.62 1557 122334 676281 45885890
Tinnitus 17.13 9.62 129 123762 27544 46534627
Seizure 16.92 9.62 437 123454 122617 46439554
Therapeutic product effect decreased 16.91 9.62 139 123752 82462 46479709
Poliomyelitis 16.77 9.62 6 123885 46 46562125
Thymus disorder 16.76 9.62 9 123882 197 46561974
Nausea 16.52 9.62 1586 122305 685868 45876303
Panic attack 16.50 9.62 101 123790 20141 46542030
Malaise 16.49 9.62 1054 122837 330178 46231993
Pneumocystis jirovecii pneumonia 16.49 9.62 10 123881 15238 46546933
No adverse event 16.45 9.62 42 123849 34189 46527982
Gastrointestinal haemorrhage 16.39 9.62 129 123762 77244 46484927
Substance abuse 16.39 9.62 35 123856 4132 46558039
Cystitis interstitial 16.37 9.62 19 123872 1323 46560848
Loss of personal independence in daily activities 16.37 9.62 87 123804 57096 46505075
Mood altered 16.20 9.62 73 123818 12934 46549237
Inhibitory drug interaction 16.08 9.62 23 123868 1972 46560199
Swelling face 15.99 9.62 213 123678 52846 46509325
Feeling of body temperature change 15.91 9.62 35 123856 4217 46557954
Dysphemia 15.89 9.62 25 123866 2333 46559838
Exposure via ingestion 15.86 9.62 31 123860 3436 46558735
Alanine aminotransferase increased 15.85 9.62 154 123737 88297 46473874
Neck pain 15.84 9.62 220 123671 55086 46507085
Dyspnoea exertional 15.83 9.62 74 123817 50215 46511956
Aggression 15.79 9.62 109 123782 22635 46539536
Flank pain 15.70 9.62 68 123823 11845 46550326
Dizziness 15.66 9.62 1076 122815 339338 46222833
Hyperlactacidaemia 15.64 9.62 24 123867 2191 46559980
Movement disorder 15.63 9.62 87 123804 16762 46545409
Premature baby 15.60 9.62 15 123876 18097 46544074
Complication associated with device 15.51 9.62 11 123880 15430 46546741
Injection site swelling 15.42 9.62 55 123836 40272 46521899
Aspartate aminotransferase increased 15.41 9.62 134 123757 78566 46483605
Antinuclear antibody positive 15.39 9.62 44 123847 6236 46555935
Parkinsonian rest tremor 15.35 9.62 7 123884 106 46562065
Condition aggravated 15.24 9.62 515 123376 244537 46317634
Drooling 15.05 9.62 29 123862 3180 46558991
Femoral artery dissection 14.88 9.62 5 123886 31 46562140
Rash 14.86 9.62 784 123107 355728 46206443
Delusion 14.85 9.62 64 123827 11124 46551047
Asthenia 14.73 9.62 675 123216 310400 46251771
Generalised anxiety disorder 14.67 9.62 20 123871 1640 46560531
Oxalosis 14.62 9.62 5 123886 33 46562138
Anoxia 14.52 9.62 9 123882 260 46561911
Therapy non-responder 14.51 9.62 58 123833 41094 46521077
Hepatic function abnormal 14.49 9.62 45 123846 34376 46527795
Lichen sclerosus 14.45 9.62 15 123876 922 46561249
Injection site pain 14.36 9.62 199 123692 106953 46455218
Haemodynamic instability 14.20 9.62 49 123842 7676 46554495
Laryngeal dyspnoea 14.07 9.62 7 123884 130 46562041
Vulvovaginal swelling 14.05 9.62 11 123880 466 46561705
Injection site bruising 14.03 9.62 48 123843 35588 46526583
Conjunctivitis 13.88 9.62 79 123812 15345 46546826
Abortion spontaneous 13.87 9.62 64 123827 43582 46518589
Bruxism 13.83 9.62 27 123864 2990 46559181
Acute myeloid leukaemia 13.67 9.62 13 123878 15765 46546406
Pneumonia 13.60 9.62 839 123052 375481 46186690
Duodenal ulcer perforation 13.51 9.62 3 123888 8499 46553672
Renal failure 13.48 9.62 216 123675 113378 46448793
Vasculitic rash 13.46 9.62 17 123874 1293 46560878
Polymenorrhoea 13.38 9.62 16 123875 1150 46561021
Myoglobin urine 13.34 9.62 4 123887 16 46562155
Infection 13.32 9.62 262 123629 133330 46428841
Abnormal loss of weight 13.32 9.62 36 123855 4939 46557232
Paralysis 13.24 9.62 52 123839 8669 46553502
Tenosynovitis 13.24 9.62 47 123844 7468 46554703
Cyanosis 13.21 9.62 80 123811 15891 46546280
Environmental exposure 13.21 9.62 6 123885 90 46562081
COVID-19 13.16 9.62 18 123873 18557 46543614
Haemophagocytic lymphohistiocytosis 13.14 9.62 3 123888 8339 46553832
Procedural anxiety 13.11 9.62 11 123880 515 46561656
Stubbornness 13.10 9.62 8 123883 225 46561946
Miosis 12.92 9.62 43 123848 6614 46555557
Pulmonary vasculitis 12.82 9.62 5 123886 50 46562121
Injection site pruritus 12.79 9.62 58 123833 39685 46522486
Otorrhoea 12.48 9.62 17 123874 1393 46560778
Gastrointestinal hypomotility 12.43 9.62 15 123876 1089 46561082
Biliary sepsis 12.35 9.62 11 123880 558 46561613
Ear haemorrhage 12.31 9.62 16 123875 1252 46560919
Hypoaesthesia oral 12.22 9.62 58 123833 10501 46551670
Herpes zoster meningoencephalitis 12.21 9.62 8 123883 255 46561916
Irritability 12.21 9.62 124 123767 28822 46533349
Hypoaesthesia 12.20 9.62 407 123484 118462 46443709
Chemical burns of eye 12.16 9.62 5 123886 58 46562113
Urinary retention 12.14 9.62 114 123777 25947 46536224
Pleural disorder 12.14 9.62 11 123880 571 46561600
Diaphragmatic paralysis 12.11 9.62 11 123880 573 46561598
Chronic sinusitis 12.08 9.62 35 123856 4998 46557173
Ischaemic stroke 12.06 9.62 16 123875 16706 46545465
Antidepressant drug level above therapeutic 12.03 9.62 9 123882 356 46561815
Renal mass 12.03 9.62 19 123872 1779 46560392
Flat affect 12.02 9.62 16 123875 1282 46560889
Bacteriuria 12.00 9.62 12 123879 705 46561466
Product monitoring error 11.98 9.62 20 123871 1961 46560210
Personality disorder 11.96 9.62 26 123865 3107 46559064
Axonal neuropathy 11.92 9.62 14 123877 988 46561183
Genital infection female 11.89 9.62 6 123885 115 46562056
Adiposis dolorosa 11.89 9.62 8 123883 267 46561904
Hypoalbuminaemia 11.88 9.62 6 123885 10121 46552050
Wrong technique in product usage process 11.87 9.62 90 123801 54332 46507839
Infection susceptibility increased 11.87 9.62 21 123870 2158 46560013
Vision blurred 11.82 9.62 286 123605 79422 46482749
Fluid retention 11.82 9.62 83 123808 50963 46511208
Lip swelling 11.79 9.62 111 123780 25284 46536887
Poor quality sleep 11.74 9.62 75 123816 15178 46546993
Accidental death 11.74 9.62 19 123872 1816 46560355
Lethargy 11.74 9.62 196 123695 50975 46511196
Staphylococcal infection 11.64 9.62 52 123839 35719 46526452
Muscle contracture 11.56 9.62 16 123875 1331 46560840
Food refusal 11.48 9.62 8 123883 283 46561888
SLE arthritis 11.44 9.62 11 123880 616 46561555
Hip arthroplasty 11.43 9.62 19 123872 18093 46544078
Myelodysplastic syndrome 11.36 9.62 15 123876 15696 46546475
Mood swings 11.35 9.62 78 123813 16174 46545997
Ulcer 11.29 9.62 82 123809 17310 46544861
Carbon monoxide poisoning 11.15 9.62 7 123884 207 46561964
Tension headache 11.14 9.62 23 123868 2651 46559520
Somnambulism 11.11 9.62 34 123857 5003 46557168
Glucose tolerance impaired 11.02 9.62 33 123858 4798 46557373
Nerve injury 10.95 9.62 45 123846 7660 46554511
Blood bilirubin increased 10.94 9.62 50 123841 34134 46528037
Hyperprolactinaemia 10.82 9.62 24 123867 2908 46559263
Nasal congestion 10.76 9.62 79 123812 48034 46514137
Pulmonary hypertension 10.73 9.62 54 123837 35939 46526232
Vaccination site oedema 10.72 9.62 4 123887 35 46562136
Post viral fatigue syndrome 10.71 9.62 6 123885 143 46562028
Neuroleptic malignant syndrome 10.70 9.62 58 123833 11064 46551107
Sinoatrial block 10.69 9.62 12 123879 806 46561365
Urticaria 10.63 9.62 235 123656 117657 46444514
Vaccination site bruising 10.62 9.62 4 123887 36 46562135
Vaccination site pruritus 10.62 9.62 4 123887 36 46562135
Oliguria 10.56 9.62 5 123886 8754 46553417
Aphasia 10.48 9.62 119 123772 28448 46533723
Central obesity 10.46 9.62 12 123879 825 46561346
Neoplasm progression 10.46 9.62 36 123855 26647 46535524
Postmortem blood drug level increased 10.46 9.62 9 123882 436 46561735
Dialysis 10.44 9.62 7 123884 10109 46552062
Pharyngeal oedema 10.43 9.62 70 123821 14401 46547770
Pleural effusion 10.43 9.62 156 123735 82796 46479375
Urinary tract infection 10.40 9.62 478 123413 219788 46342383
Product quality issue 10.33 9.62 54 123837 35594 46526577
Pericardial effusion 10.33 9.62 34 123857 25509 46536662
Red blood cell sedimentation rate increased 10.31 9.62 29 123862 22860 46539311
Device dislocation 10.28 9.62 27 123864 21775 46540396
Ejection fraction decreased 10.26 9.62 20 123871 17917 46544254
Metabolic acidosis 10.20 9.62 152 123739 38628 46523543
Intestinal adenocarcinoma 10.18 9.62 6 123885 158 46562013
Cough 10.02 9.62 504 123387 229745 46332426
Metabolic myopathy 10.01 9.62 3 123888 12 46562159
Ovarian adhesion 10.01 9.62 3 123888 12 46562159
Neurogenic shock 10.01 9.62 7 123884 249 46561922
Death 9.97 9.62 761 123130 334787 46227384
Myelosuppression 9.92 9.62 4 123887 7699 46554472
Overlap syndrome 9.87 9.62 10 123881 597 46561574
Febrile bone marrow aplasia 9.80 9.62 3 123888 6859 46555312
Fluid overload 9.79 9.62 38 123853 27147 46535024
Naevus haemorrhage 9.72 9.62 5 123886 100 46562071
Anti-neutrophil cytoplasmic antibody positive vasculitis 9.71 9.62 18 123873 1917 46560254
Thyroid adenoma 9.69 9.62 6 123885 173 46561998
Epstein-Barr virus infection 9.63 9.62 3 123888 6781 46555390
Incorrect dose administered 9.62 9.62 76 123815 45474 46516697

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 359.58 10.57 839 46957 176344 29728338
Completed suicide 249.95 10.57 514 47282 98978 29805704
Serotonin syndrome 243.96 10.57 213 47583 17678 29887004
Overdose 221.58 10.57 444 47352 83893 29820789
Drug abuse 135.54 10.57 360 47436 81712 29822970
Electrocardiogram QRS complex prolonged 118.90 10.57 78 47718 4199 29900483
Coma 113.35 10.57 219 47577 40230 29864452
Intentional overdose 107.08 10.57 217 47579 41264 29863418
Migraine 91.86 10.57 108 47688 12766 29891916
Respiratory arrest 69.55 10.57 148 47648 29110 29875572
Allodynia 66.04 10.57 28 47768 605 29904077
Suicide attempt 64.60 10.57 165 47631 36532 29868150
Poisoning deliberate 62.39 10.57 61 47735 5843 29898839
Confusional state 60.47 10.57 395 47401 134439 29770243
Somnolence 60.03 10.57 309 47487 96454 29808228
Coombs positive haemolytic anaemia 54.75 10.57 26 47770 739 29903943
Poisoning 53.87 10.57 78 47718 11304 29893378
Suicidal ideation 45.58 10.57 144 47652 35970 29868712
Lymphadenitis 39.78 10.57 28 47768 1692 29902990
Depression 39.31 10.57 263 47533 90174 29814508
Febrile neutropenia 39.04 10.57 69 47727 106624 29798058
Hyperaesthesia 37.91 10.57 37 47759 3536 29901146
Sedation 36.81 10.57 81 47715 16292 29888390
Disturbance in attention 36.37 10.57 97 47699 22032 29882650
Cardiac arrest 35.65 10.57 262 47534 92588 29812094
Brugada syndrome 35.54 10.57 18 47778 590 29904092
Platelet count decreased 35.02 10.57 73 47723 106056 29798626
Delusion of replacement 34.76 10.57 12 47784 144 29904538
Depressed level of consciousness 34.11 10.57 136 47660 38086 29866596
Delirium 33.44 10.57 141 47655 40490 29864192
Colour blindness acquired 33.38 10.57 10 47786 73 29904609
Anxiety 31.36 10.57 248 47548 89623 29815059
Drug withdrawal syndrome neonatal 30.23 10.57 31 47765 3144 29901538
Diarrhoea 30.14 10.57 365 47431 333738 29570944
Patient dissatisfaction with treatment 29.88 10.57 9 47787 67 29904615
Anaemia 29.77 10.57 202 47594 207790 29696892
Drug withdrawal syndrome 29.74 10.57 84 47712 19725 29884957
Agitation 29.63 10.57 167 47629 53906 29850776
Agitation neonatal 29.24 10.57 19 47777 1006 29903676
Myoclonus 28.96 10.57 65 47731 13247 29891435
Foetal disorder 28.63 10.57 16 47780 642 29904040
Disease progression 28.01 10.57 53 47743 79821 29824861
Neutropenia 27.94 10.57 108 47688 128432 29776250
Unresponsive to stimuli 27.71 10.57 99 47697 26320 29878362
Respiratory depression 27.10 10.57 58 47738 11445 29893237
Dysarthria 26.81 10.57 108 47688 30382 29874300
Hallucination 26.54 10.57 151 47645 48908 29855774
Agoraphobia 26.32 10.57 11 47785 229 29904453
Substance abuse 25.96 10.57 43 47753 6997 29897685
Intentional product misuse 25.25 10.57 116 47680 34551 29870131
Cytomegalovirus infection 24.81 10.57 4 47792 23670 29881012
White blood cell count decreased 24.25 10.57 62 47734 83885 29820797
Tremor 23.61 10.57 203 47593 75160 29829522
Depressed mood 23.43 10.57 70 47726 16959 29887723
Thrombocytopenia 23.31 10.57 126 47670 136918 29767764
Neutropenia neonatal 23.12 10.57 13 47783 528 29904154
Death 22.95 10.57 417 47379 356866 29547816
Atrial fibrillation 22.75 10.57 92 47704 108032 29796650
Multiple drug therapy 22.73 10.57 10 47786 237 29904445
Drug dependence 22.50 10.57 80 47716 21215 29883467
Sopor 22.07 10.57 52 47744 10939 29893743
Chemical submission 21.63 10.57 6 47790 32 29904650
Inadequate analgesia 21.47 10.57 24 47772 2684 29901998
Burning sensation 21.06 10.57 66 47730 16408 29888274
Astigmatism 21.05 10.57 14 47782 771 29903911
Femoral nerve palsy 21.03 10.57 6 47790 36 29904646
Acute lung injury 21.03 10.57 16 47780 1091 29903591
Hallucination, visual 21.01 10.57 65 47731 16048 29888634
Sepsis 21.01 10.57 142 47654 146253 29758429
Acute psychosis 20.98 10.57 20 47776 1856 29902826
Panic attack 20.71 10.57 44 47752 8637 29896045
Alcoholic ketoacidosis 20.06 10.57 5 47791 16 29904666
Accidental overdose 19.60 10.57 69 47727 18206 29886476
HIV peripheral neuropathy 19.55 10.57 6 47790 48 29904634
Mydriasis 19.35 10.57 35 47761 6108 29898574
Cardio-respiratory arrest 19.35 10.57 157 47639 57149 29847533
Withdrawal syndrome 19.18 10.57 50 47746 11200 29893482
Paranoia 19.16 10.57 47 47749 10141 29894541
Pyrexia 19.10 10.57 343 47453 294146 29610536
Cardiotoxicity 19.09 10.57 29 47767 4385 29900297
Muscle twitching 19.07 10.57 41 47755 8114 29896568
Off label use 18.92 10.57 282 47514 249008 29655674
Urine sodium decreased 18.41 10.57 8 47788 184 29904498
Pneumocystis jirovecii pneumonia 17.70 10.57 3 47793 17117 29887565
Cyclic vomiting syndrome 17.67 10.57 5 47791 29 29904653
Loss of consciousness 17.62 10.57 199 47597 79176 29825506
Interstitial lung disease 16.96 10.57 45 47751 60152 29844530
Electric shock 16.69 10.57 7 47789 147 29904535
Quality of life decreased 16.63 10.57 23 47773 3194 29901488
Ataxia 16.61 10.57 48 47748 11414 29893268
Dyspnoea 16.39 10.57 406 47390 332889 29571793
Facial pain 16.28 10.57 17 47779 1760 29902922
Renal impairment 16.25 10.57 74 47722 84110 29820572
Hypomania 16.21 10.57 19 47777 2237 29902445
Family stress 16.19 10.57 7 47789 159 29904523
Disorientation 15.88 10.57 95 47701 31323 29873359
Paraesthesia 15.80 10.57 144 47652 54183 29850499
Sedation complication 15.72 10.57 12 47784 822 29903860
Fall 15.57 10.57 390 47406 181482 29723200
Thoracic vertebral fracture 15.44 10.57 15 47781 1425 29903257
Drug ineffective for unapproved indication 15.23 10.57 45 47751 10835 29893847
Insomnia 15.21 10.57 221 47575 93115 29811567
Victim of crime 15.19 10.57 8 47788 285 29904397
Dyskinesia 15.12 10.57 72 47724 21762 29882920
Insulin resistance 15.01 10.57 10 47786 552 29904130
Velopharyngeal incompetence 14.80 10.57 4 47792 19 29904663
Clonus 14.76 10.57 19 47777 2462 29902220
Tonsillar ulcer 14.71 10.57 7 47789 200 29904482
Stomatitis 14.65 10.57 23 47773 37256 29867426
Aggression 14.63 10.57 105 47691 36802 29867880
Urticaria 14.51 10.57 42 47754 54564 29850118
Arteriosclerosis coronary artery 14.49 10.57 45 47751 11131 29893551
Ventricular hypoplasia 14.19 10.57 5 47791 64 29904618
Accidental death 14.10 10.57 17 47779 2062 29902620
Central pain syndrome 14.09 10.57 6 47790 131 29904551
Hypotonia 14.09 10.57 33 47763 6915 29897767
Sitting disability 14.05 10.57 5 47791 66 29904616
Nystagmus 14.03 10.57 25 47771 4313 29900369
Hypoaesthesia 13.92 10.57 140 47656 54090 29850592
Gastrointestinal hypomotility 13.88 10.57 12 47784 981 29903701
Pain 13.84 10.57 367 47429 172274 29732408
Haemoglobin decreased 13.82 10.57 116 47680 113982 29790700
Drug screen positive 13.75 10.57 25 47771 4382 29900300
Lower respiratory tract infection 13.64 10.57 81 47715 26633 29878049
Mast cell degranulation present 13.59 10.57 5 47791 73 29904609
Rash 13.55 10.57 220 47576 191669 29713013
Constipation 13.46 10.57 254 47542 112652 29792030
Dissociative amnesia 13.23 10.57 5 47791 79 29904603
Generalised tonic-clonic seizure 13.20 10.57 64 47732 19487 29885195
Sensorimotor disorder 13.19 10.57 8 47788 375 29904307
Hypotension 13.17 10.57 233 47563 200332 29704350
Diabetic autonomic neuropathy 13.04 10.57 3 47793 6 29904676
Haematuria 13.02 10.57 33 47763 44801 29859881
Neurosis 13.02 10.57 6 47790 159 29904523
Decreased appetite 12.99 10.57 165 47631 149745 29754937
Clonic convulsion 12.96 10.57 9 47787 532 29904150
Sinus tachycardia 12.90 10.57 54 47742 15450 29889232
Pulmonary valve disease 12.89 10.57 5 47791 85 29904597
Erectile dysfunction 12.76 10.57 60 47736 18042 29886640
Pneumonia 12.68 10.57 422 47374 333884 29570798
Drug interaction 12.65 10.57 412 47384 199156 29705526
Product dose omission issue 12.58 10.57 90 47706 91541 29813141
Skull fracture 12.53 10.57 11 47785 918 29903764
Neuralgia 12.53 10.57 41 47755 10425 29894257
Neutrophil count decreased 12.52 10.57 31 47765 42423 29862259
Exposure via ingestion 12.51 10.57 18 47778 2593 29902089
Sleep deficit 12.39 10.57 8 47788 419 29904263
Plasma cell myeloma 12.20 10.57 44 47752 53418 29851264
Lid lag 12.18 10.57 3 47793 9 29904673
Panic disorder 12.15 10.57 12 47784 1163 29903519
Pulmonary congestion 12.00 10.57 45 47751 12242 29892440
Electrocardiogram QT prolonged 11.99 10.57 98 47698 35737 29868945
Renal failure 11.91 10.57 140 47656 128826 29775856
Tongue spasm 11.90 10.57 4 47792 44 29904638
Balance disorder 11.79 10.57 99 47697 36394 29868288
Dysaesthesia 11.78 10.57 16 47780 2185 29902497
Therapy non-responder 11.73 10.57 18 47778 29435 29875247
Coma scale abnormal 11.62 10.57 20 47776 3356 29901326
Chylothorax 11.61 10.57 9 47787 631 29904051
Anaphylactic shock 11.45 10.57 4 47792 13989 29890693
Hyperhidrosis 11.38 10.57 160 47636 66930 29837752
Cough 11.37 10.57 137 47659 125505 29779177
Nephrolithiasis 11.27 10.57 73 47723 24737 29879945
Haematoma 11.21 10.57 13 47783 23940 29880742
Tension headache 11.19 10.57 12 47784 1281 29903401
Colour blindness 11.18 10.57 6 47790 222 29904460
Hospitalisation 11.12 10.57 35 47761 44284 29860398
Temperature regulation disorder 11.07 10.57 8 47788 504 29904178
Hypokalaemia 11.00 10.57 42 47754 50150 29854532
Bronchopulmonary aspergillosis 10.97 10.57 3 47793 12281 29892401
Sports injury 10.90 10.57 5 47791 131 29904551
Dry mouth 10.85 10.57 68 47728 22782 29881900
Victim of homicide 10.83 10.57 5 47791 133 29904549
Circulatory collapse 10.78 10.57 62 47734 20152 29884530
Drug diversion 10.69 10.57 10 47786 906 29903776
Behaviour disorder 10.65 10.57 16 47780 2396 29902286

Pharmacologic Action:

SourceCodeDescription
ATC N06AA09 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Non-selective monoamine reuptake inhibitors
ATC N06CA01 NERVOUS SYSTEM
PSYCHOANALEPTICS
PSYCHOLEPTICS AND PSYCHOANALEPTICS IN COMBINATION
Antidepressants in combination with psycholeptics
FDA EPC N0000175752 Tricyclic Antidepressant
MeSH PA D018663 Adrenergic Agents
MeSH PA D018759 Adrenergic Uptake Inhibitors
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000928 Antidepressive Agents
MeSH PA D000929 Antidepressive Agents, Tricyclic
MeSH PA D002491 Central Nervous System Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35469 thymoanaleptics
CHEBI has role CHEBI:35640 adrenergic uptake inhibitors
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:140489 trkb receptor agonists

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Depressive disorder indication 35489007
Mixed anxiety and depressive disorder indication 231504006
Posttraumatic stress disorder off-label use 47505003 DOID:2055
Bulimia nervosa off-label use 78004001
Fibromyalgia off-label use 203082005 DOID:631
Neuropathic pain off-label use 247398009
Migraine Prevention off-label use
Suicidal thoughts contraindication 6471006
Alcoholism contraindication 7200002
Organophosphate poisoning contraindication 8260003
Weight gain finding contraindication 8943002
Sinus tachycardia contraindication 11092001
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Chronic disease of respiratory system contraindication 17097001
Disorder of lung contraindication 19829001 DOID:850
Myocardial infarction contraindication 22298006 DOID:5844
Glaucoma contraindication 23986001 DOID:1686
Alcohol intoxication contraindication 25702006
Shock contraindication 27942005
Orthostatic hypotension contraindication 28651003
Torsades de pointes contraindication 31722008
Parkinsonism contraindication 32798002
Hyperthyroidism contraindication 34486009 DOID:7998
Hyperactive behavior contraindication 44548000
Conduction disorder of the heart contraindication 44808001
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Paralytic ileus contraindication 55525008 DOID:8442
Substance abuse contraindication 66214007
Psychotic disorder contraindication 69322001
Sleep apnea contraindication 73430006 DOID:0050847
Extrapyramidal disease contraindication 76349003
Hyperglycemia contraindication 80394007 DOID:4195
Chronic idiopathic constipation contraindication 82934008
Open-angle glaucoma contraindication 84494001 DOID:1067
Epilepsy contraindication 84757009 DOID:1826
Leukopenia contraindication 84828003 DOID:615
Stupor contraindication 89458003
Kidney disease contraindication 90708001 DOID:557
Tardive dyskinesia contraindication 102449007
Prolonged QT interval contraindication 111975006
Hypoalbuminemia contraindication 119247004
Acute disease of cardiovascular system contraindication 128487001
Bipolar affective disorder, current episode manic contraindication 191618007
Angina pectoris contraindication 194828000
Disease of liver contraindication 235856003 DOID:409
Metabolic syndrome X contraindication 237602007 DOID:14221
Hyperprolactinemia contraindication 237662005 DOID:12700
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Syncope contraindication 271594007
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Severe chronic obstructive pulmonary disease contraindication 313299006
Coma contraindication 371632003
At risk for aspiration contraindication 371736008
Angle-closure glaucoma contraindication 392291006 DOID:13550
Visual impairment contraindication 397540003
Breastfeeding (mother) contraindication 413712001
Myocardial ischemia contraindication 414795007 DOID:3393
Obesity contraindication 414916001 DOID:9970
Myocardial infarction in recovery phase contraindication 418044006
Porphyria contraindication 418470004
Congenital long QT syndrome contraindication 442917000
Carcinoma of female breast contraindication 447782002

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.66 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR Kd 8.37 WOMBAT-PK CHEMBL
Sodium-dependent noradrenaline transporter Transporter INHIBITOR Kd 7.46 WOMBAT-PK CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 6.88 DRUG MATRIX
Alpha-2C adrenergic receptor GPCR Ki 8.07 DRUG MATRIX
Alpha-1D adrenergic receptor GPCR Ki 8.25 DRUG MATRIX
Sodium channel protein type 5 subunit alpha Ion channel IC50 5.80 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 5.21 CHEMBL
Solute carrier family 22 member 1 Transporter IC50 4.77 CHEMBL
Sodium channel protein type 9 subunit alpha Ion channel IC50 6 CHEMBL
Sodium channel protein type 2 subunit alpha Ion channel IC50 5.51 CHEMBL
5-hydroxytryptamine receptor 2C GPCR Ki 8.10 WOMBAT-PK
5-hydroxytryptamine receptor 2A GPCR Ki 7.96 WOMBAT-PK
Solute carrier family 22 member 2 Transporter IC50 4.85 WOMBAT-PK
Histamine H4 receptor GPCR Ki 8.14 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR IC50 8 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR IC50 7.90 WOMBAT-PK
5-hydroxytryptamine receptor 6 GPCR Ki 7.05 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR Ki 7.40 WOMBAT-PK
D(1A) dopamine receptor GPCR Ki 7.05 WOMBAT-PK
Sigma non-opioid intracellular receptor 1 Membrane receptor IC50 6.25 WOMBAT-PK
Aldehyde oxidase Enzyme IC50 6.59 WOMBAT-PK
Muscarinic acetylcholine receptor M5 GPCR Ki 7.80 WOMBAT-PK
Muscarinic acetylcholine receptor M4 GPCR Ki 8.14 WOMBAT-PK
Muscarinic acetylcholine receptor M3 GPCR Ki 7.89 WOMBAT-PK
Muscarinic acetylcholine receptor M2 GPCR Ki 8.10 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR ANTAGONIST Ki 7.83 WOMBAT-PK
Histamine H2 receptor GPCR IC50 6.80 WOMBAT-PK
Histamine H1 receptor GPCR ANTAGONIST Ki 9.30 WOMBAT-PK
D(1B) dopamine receptor GPCR Ki 6.77 WOMBAT-PK
D(3) dopamine receptor GPCR Ki 6.69 WOMBAT-PK
5-hydroxytryptamine receptor 7 GPCR Ki 6.40 WOMBAT-PK
5-hydroxytryptamine receptor 1A GPCR Ki 6.72 WOMBAT-PK
D(2) dopamine receptor GPCR Ki 6.71 WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5 WOMBAT-PK
High affinity nerve growth factor receptor Kinase IC50 4.22 CHEMBL
Proto-oncogene tyrosine-protein kinase receptor Ret Kinase IC50 6 CHEMBL
5-hydroxytryptamine receptor 2C GPCR ANTAGONIST Ki 8.10 IUPHAR
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 8.40 IUPHAR
5-hydroxytryptamine receptor 7 GPCR ANTAGONIST Ki 6.40 IUPHAR
G protein-activated inward rectifier potassium channel 2 Ion channel BLOCKER IC50 4 IUPHAR
Alpha-1B adrenergic receptor GPCR Ki 7.38 DRUG MATRIX
5-hydroxytryptamine receptor 1B GPCR Ki 5.77 DRUG MATRIX
Sodium-dependent serotonin transporter Transporter IC50 5.07 CHEMBL
Alpha-1A adrenergic receptor GPCR IC50 10.70 CHEMBL
Transporter Transporter IC50 5.60 CHEMBL
Muscarinic acetylcholine receptor GPCR IC50 6.52 CHEMBL
Histamine H1 receptor GPCR IC50 10.70 CHEMBL
5-hydroxytryptamine receptor 6 GPCR ANTAGONIST Ki 7.20 IUPHAR
5-hydroxytryptamine receptor 1A GPCR IC50 5.70 CHEMBL
5-hydroxytryptamine receptor 7 GPCR ANTAGONIST Ki 7 IUPHAR

External reference:

IDSource
1806D8D52K UNII
4019607 VUID
N0000147702 NUI
D00809 KEGG_DRUG
549-18-8 SECONDARY_CAS_RN
C0002600 UMLSCUI
CHEBI:2666 CHEBI
TP0 PDB_CHEM_ID
CHEMBL629 ChEMBL_ID
CHEMBL1200964 ChEMBL_ID
DB00321 DRUGBANK_ID
D000639 MESH_DESCRIPTOR_UI
2160 PUBCHEM_CID
976 INN_ID
200 IUPHAR_LIGAND_ID
203168 RXNORM
4178 MMSL
4240 MMSL
d00146 MMSL
001501 NDDF
004600 NDDF
372726002 SNOMEDCT_US
40589005 SNOMEDCT_US
48384000 SNOMEDCT_US
4017743 VANDF
4019607 VANDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Perphenazine and Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 2 0378-0042 TABLET, FILM COATED 10 mg ORAL ANDA 20 sections
Perphenazine and Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 2 0378-0073 TABLET, FILM COATED 50 mg ORAL ANDA 20 sections
Chlordiazepoxide and Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 2 0378-0211 TABLET, FILM COATED 14 mg ORAL ANDA 24 sections
Chlordiazepoxide and Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 2 0378-0277 TABLET, FILM COATED 27.98 mg ORAL ANDA 24 sections
Perphenazine and Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 2 0378-0330 TABLET, FILM COATED 10 mg ORAL ANDA 20 sections
Perphenazine and Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 2 0378-0442 TABLET, FILM COATED 25 mg ORAL ANDA 20 sections
Perphenazine and Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 2 0378-0574 TABLET, FILM COATED 25 mg ORAL ANDA 20 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0463-6351 TABLET, FILM COATED 25 mg ORAL ANDA 23 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0463-6352 TABLET, FILM COATED 50 mg ORAL ANDA 23 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0463-6354 TABLET, FILM COATED 100 mg ORAL ANDA 23 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0603-2212 TABLET, FILM COATED 10 mg ORAL ANDA 23 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0603-2213 TABLET, FILM COATED 25 mg ORAL ANDA 23 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0603-2214 TABLET, FILM COATED 50 mg ORAL ANDA 23 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0603-2215 TABLET, FILM COATED 75 mg ORAL ANDA 23 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0603-2216 TABLET, FILM COATED 100 mg ORAL ANDA 23 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0603-2217 TABLET, FILM COATED 150 mg ORAL ANDA 23 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-1486 TABLET, FILM COATED 10 mg ORAL ANDA 21 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-1487 TABLET, FILM COATED 25 mg ORAL ANDA 21 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-1488 TABLET, FILM COATED 50 mg ORAL ANDA 21 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-1489 TABLET, FILM COATED 75 mg ORAL ANDA 21 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-1490 TABLET, FILM COATED 100 mg ORAL ANDA 21 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-1491 TABLET, FILM COATED 150 mg ORAL ANDA 21 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-0201 TABLET, FILM COATED 25 mg ORAL ANDA 21 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-0202 TABLET, FILM COATED 50 mg ORAL ANDA 21 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-109 TABLET, FILM COATED 25 mg ORAL ANDA 22 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-110 TABLET, FILM COATED 50 mg ORAL ANDA 22 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-250 TABLET, FILM COATED 10 mg ORAL ANDA 22 sections
AMITRIPTYLINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-011 TABLET, FILM COATED 10 mg ORAL ANDA 23 sections
AMITRIPTYLINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-012 TABLET, FILM COATED 25 mg ORAL ANDA 23 sections
AMITRIPTYLINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-013 TABLET, FILM COATED 50 mg ORAL ANDA 23 sections