amitriptyline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antidepressants, dibenzo[a,d]cycloheptane or cyclopheptene derivatives 180 50-48-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • amitriptyline
  • amitriprolidine
  • amitriptylin
  • damitriptyline
  • amitriptyline hydrochloride
  • amitryptiline
  • amitryptiline hydrochloride
  • amitriptyline HCl
  • amitryptiline HCl
Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
  • Molecular weight: 277.41
  • Formula: C20H23N
  • CLOGP: 4.85
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA: 3.24
  • ALOGS: -4.79
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
75 mg O
75 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 31.39 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 15.45 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 48 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 8.70 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 6.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.07 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 17 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT1,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPKAPK2,MET,NTRK2,PDK2,PDK4,PDPK1,PIM2,PRKDC,SIK2,SIK3,STK33,TEK,TGFBR1,TTK 42
kinase-selectivity-class AXL,BRAF,PDK4,STK33,TTK 5
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.566 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1
rat-kpuu-brain Rat brain Kpuu 1.242 % High 1

Approvals:

DateAgencyCompanyOrphan
April 7, 1961 FDA ASTRAZENECA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 1030.94 9.30 1897 168248 285949 90172353
Completed suicide 690.48 9.30 1086 169059 143972 90314330
Cognitive disorder 588.00 9.30 688 169457 68719 90389583
Pemphigus 555.50 9.30 12 170133 326852 90131450
Orthostatic hypotension 493.55 9.30 494 169651 41333 90416969
Sedation complication 492.86 9.30 338 169807 16606 90441696
Creatinine renal clearance decreased 491.49 9.30 352 169793 18547 90439755
Sedation 485.82 9.30 523 169622 47648 90410654
Depressed level of consciousness 465.63 9.30 627 169518 72157 90386145
Systemic lupus erythematosus 442.43 9.30 74 170071 361822 90096480
Glossodynia 406.41 9.30 60 170085 321719 90136583
Anti-cyclic citrullinated peptide antibody positive 404.31 9.30 8 170137 236425 90221877
Blood calcium decreased 396.32 9.30 378 169767 29804 90428498
Wound 379.16 9.30 58 170087 302922 90155380
Balance disorder 377.40 9.30 664 169481 96416 90361886
Hand deformity 370.25 9.30 57 170088 296305 90161997
Coma 363.73 9.30 557 169588 72075 90386227
Drug abuse 354 9.30 589 169556 81758 90376544
Duodenal ulcer perforation 326.34 9.30 23 170122 221265 90237037
Serotonin syndrome 319.81 9.30 375 169770 37512 90420790
Arthropathy 310.05 9.30 150 169995 366092 90092210
Hepatic enzyme increased 306.51 9.30 147 169998 360589 90097713
Muscle injury 283.48 9.30 11 170134 176643 90281659
Synovitis 279.17 9.30 135 170010 329617 90128685
Electrocardiogram QRS complex prolonged 278.38 9.30 173 169972 7175 90451127
Folliculitis 275.03 9.30 31 170114 204322 90253980
Rheumatoid factor positive 261.52 9.30 15 170130 171635 90286667
Rheumatic fever 251.04 9.30 8 170137 153113 90305189
Helicobacter infection 235.35 9.30 67 170078 226783 90231519
Infusion related reaction 230.25 9.30 266 169879 416514 90041788
Pericarditis 228.00 9.30 111 170034 270040 90188262
Impaired healing 223.74 9.30 80 170065 234119 90224183
Sleep disorder due to general medical condition, insomnia type 217.38 9.30 5 170140 128689 90329613
Disturbance in attention 214.61 9.30 346 169799 46763 90411539
Drug ineffective for unapproved indication 212.78 9.30 419 169726 66225 90392077
Irritable bowel syndrome 212.01 9.30 63 170082 207385 90250917
Fall 209.95 9.30 1585 168560 480225 89978077
Hypotension 197.57 9.30 1163 168982 324234 90134068
Somnolence 193.71 9.30 842 169303 208242 90250060
Electrocardiogram QT prolonged 190.90 9.30 421 169724 72035 90386267
Drug interaction 188.90 9.30 1020 169125 275433 90182869
Liver injury 183.25 9.30 47 170098 170520 90287782
Alopecia 183.05 9.30 412 169733 494659 89963643
Maternal exposure during pregnancy 182.88 9.30 245 169900 359818 90098484
Constipation 181.84 9.30 1020 169125 279375 90178927
Swollen joint count increased 181.60 9.30 6 170139 111200 90347102
Swelling 180.42 9.30 319 169826 418739 90039563
Poisoning deliberate 178.59 9.30 186 169959 16300 90442002
Type 2 diabetes mellitus 175.30 9.30 81 170064 203163 90255139
Abdominal discomfort 170.99 9.30 404 169741 476924 89981378
Tachycardia 161.61 9.30 655 169490 157018 90301284
Contraindicated product administered 153.41 9.30 227 169918 319912 90138390
Hyperhidrosis 153.26 9.30 583 169562 135722 90322580
Overdose 150.54 9.30 641 169504 157068 90301234
Lip dry 150.21 9.30 10 170135 100945 90357357
Intentional overdose 149.35 9.30 451 169694 93383 90364919
Discomfort 149.32 9.30 177 169968 274158 90184144
Exposure during pregnancy 148.68 9.30 137 170008 238273 90220029
Mydriasis 147.81 9.30 161 169984 14851 90443451
C-reactive protein abnormal 145.01 9.30 31 170114 127398 90330904
Impaired work ability 143.04 9.30 179 169966 19147 90439155
Tension headache 142.61 9.30 116 170029 7393 90450909
Blister 141.49 9.30 162 169983 254836 90203466
Tinnitus 141.22 9.30 274 169871 42828 90415474
Muscle twitching 138.95 9.30 198 169947 24004 90434298
Hypersensitivity 137.72 9.30 418 169727 454259 90004043
Breast cancer stage III 136.33 9.30 5 170140 84442 90373860
Lip swelling 133.34 9.30 251 169894 38359 90419943
Ill-defined disorder 133.14 9.30 92 170053 184799 90273503
Hallucination 129.41 9.30 342 169803 65617 90392685
Peripheral venous disease 128.82 9.30 7 170138 83914 90374388
Anticholinergic syndrome 128.38 9.30 74 170071 2669 90455633
Cardiospasm 127.68 9.30 80 170065 3366 90454936
Palmoplantar keratoderma 126.39 9.30 80 170065 3427 90454875
Pruritus genital 125.67 9.30 88 170057 4470 90453832
Medication overuse headache 120.24 9.30 58 170087 1443 90456859
General physical health deterioration 119.68 9.30 310 169835 354805 90103497
Migraine 119.62 9.30 687 169458 189705 90268597
Injury 118.83 9.30 117 170028 197232 90261070
Suicidal ideation 118.48 9.30 356 169789 73499 90384803
Therapeutic product effect decreased 116.93 9.30 214 169931 277357 90180945
Oedema 116.89 9.30 122 170023 200173 90258129
Psoriatic arthropathy 114.19 9.30 157 169988 228178 90230124
Sleep terror 111.15 9.30 81 170064 4383 90453919
Agitation 109.12 9.30 325 169820 66773 90391529
Atrial tachycardia 108.45 9.30 90 170055 5900 90452402
Hypercholesterolaemia 107.96 9.30 28 170117 100864 90357438
Wound infection 107.42 9.30 33 170112 106369 90351933
Grip strength decreased 106.40 9.30 22 170123 92554 90365748
Facet joint syndrome 105.87 9.30 27 170118 98362 90359940
Deep vein thrombosis postoperative 105.38 9.30 7 170138 70802 90387500
Stomatitis 104.34 9.30 225 169920 274473 90183829
Withdrawal syndrome 103.34 9.30 166 169979 22358 90435944
Ventricular tachycardia 102.47 9.30 174 169971 24534 90433768
Pulmonary fibrosis 102.14 9.30 37 170108 107466 90350836
Immunisation 101.71 9.30 59 170086 2154 90456148
Blood cholesterol increased 101.05 9.30 146 169999 207866 90250436
Swelling face 98.12 9.30 356 169789 80996 90377306
Gastric pH decreased 97.27 9.30 44 170101 942 90457360
Derealisation 97.13 9.30 50 170095 1435 90456867
Live birth 96.92 9.30 16 170129 79091 90379211
Tenosynovitis stenosans 96.77 9.30 71 170074 3882 90454420
Feeling jittery 96.07 9.30 131 170014 15240 90443062
Synovial fluid analysis 95.90 9.30 62 170083 2756 90455546
Swollen tongue 93.94 9.30 242 169903 45714 90412588
Nightmare 92.76 9.30 155 169990 21570 90436732
Gait inability 92.65 9.30 83 170062 146373 90311929
Poor quality sleep 90.87 9.30 165 169980 24528 90433774
Carotid artery occlusion 90.09 9.30 83 170062 6259 90452043
Feeling abnormal 88.92 9.30 578 169567 166657 90291645
Joint range of motion decreased 86.85 9.30 76 170069 135567 90322735
Adjustment disorder with depressed mood 86.28 9.30 5 170140 56748 90401554
Joint swelling 86.20 9.30 572 169573 502728 89955574
Dislocation of vertebra 84.88 9.30 5 170140 55963 90402339
Lower limb fracture 84.68 9.30 27 170118 84986 90373316
Blepharospasm 83.94 9.30 5 170140 55440 90402862
Crepitations 83.79 9.30 93 170052 8759 90449543
Restless legs syndrome 83.78 9.30 151 169994 22319 90435983
Scleritis 83.55 9.30 73 170072 5135 90453167
Facial pain 83.38 9.30 113 170032 13069 90445233
Tremor 82.41 9.30 531 169614 152642 90305660
Dizziness 82.33 9.30 1558 168587 587726 89870576
Hallucinations, mixed 81.58 9.30 76 170069 5813 90452489
Rubber sensitivity 81.09 9.30 56 170089 2781 90455521
Cogwheel rigidity 80.92 9.30 50 170095 2052 90456250
Autoimmune disorder 80.78 9.30 22 170123 76722 90381580
Urinary retention 80.52 9.30 202 169943 37542 90420760
Depressed mood 79.52 9.30 241 169904 49981 90408321
Photophobia 79.39 9.30 143 170002 21126 90437176
Depersonalisation/derealisation disorder 78.98 9.30 45 170100 1587 90456715
Anxiety 78.86 9.30 909 169236 308863 90149439
Cardio-respiratory arrest 78.43 9.30 279 169866 62861 90395441
Myelosuppression 77.72 9.30 6 170139 53585 90404717
Neutropenia 77.51 9.30 194 169951 224710 90233592
Hallucination, visual 77.11 9.30 148 169997 22944 90435358
Gastrointestinal disorder 76.18 9.30 238 169907 256449 90201853
H1N1 influenza 75.32 9.30 47 170098 1963 90456339
Feeling of despair 74.96 9.30 56 170089 3148 90455154
Eye pain 74.73 9.30 217 169928 43951 90414351
Pleuritic pain 74.41 9.30 95 170050 10366 90447936
Myoclonus 74.27 9.30 131 170014 19037 90439265
Heart rate increased 73.24 9.30 411 169734 112491 90345811
Respiratory depression 73.12 9.30 116 170029 15459 90442843
Obesity 72.67 9.30 55 170090 105452 90352850
Infection 70.59 9.30 395 169750 361699 90096603
Lip pruritus 69.88 9.30 39 170106 1321 90456981
Hip arthroplasty 69.44 9.30 28 170117 76180 90382122
Vasculitis 69.19 9.30 140 170005 22553 90435749
Neovascularisation 68.46 9.30 41 170104 1589 90456713
Dystonia 67.84 9.30 117 170028 16702 90441600
Anosmia 67.80 9.30 88 170057 9760 90448542
Feeling of body temperature change 67.12 9.30 67 170078 5582 90452720
Night sweats 66.93 9.30 86 170059 128680 90329622
Palpitations 66.92 9.30 463 169682 136265 90322037
Flank pain 66.41 9.30 125 170020 19097 90439205
Diplopia 65.84 9.30 158 169987 28556 90429746
Body tinea 65.19 9.30 44 170101 2104 90456198
Knee arthroplasty 64.50 9.30 38 170107 83144 90375158
Onychomadesis 64.38 9.30 6 170139 45992 90412310
Cardiac arrest 63.49 9.30 375 169770 104560 90353742
Platelet count decreased 61.83 9.30 101 170044 136868 90321434
Brain injury 61.01 9.30 74 170071 7664 90450638
Lower respiratory tract infection 60.72 9.30 253 169892 250406 90207896
Loss of consciousness 60.64 9.30 461 169684 139777 90318525
Inhibitory drug interaction 60.35 9.30 49 170096 3114 90455188
Angioedema 59.78 9.30 261 169884 64615 90393687
Vision blurred 59.70 9.30 383 169762 109910 90348392
Blindness 59.64 9.30 145 170000 26423 90431879
Sinusitis 59.13 9.30 389 169756 342699 90115603
Condition aggravated 59.02 9.30 776 169369 594769 89863533
Emotional disorder 58.76 9.30 103 170042 14894 90443408
Bradypnoea 58.60 9.30 57 170088 4601 90453701
Neuralgia 58.42 9.30 160 169985 31340 90426962
Lupus vulgaris 57.74 9.30 8 170137 45051 90413251
Bone density decreased 57.71 9.30 111 170034 17234 90441068
Drug withdrawal syndrome 56.39 9.30 149 169996 28574 90429728
Vertigo 55.54 9.30 269 169876 69542 90388760
Speech disorder 55.39 9.30 200 169945 45385 90412917
Suicide attempt 55.36 9.30 284 169861 75115 90383187
Accidental death 55.20 9.30 39 170106 2009 90456293
Pain of skin 54.84 9.30 104 170041 15978 90442324
Tenosynovitis 54.44 9.30 98 170047 14469 90443833
Red blood cell sedimentation rate increased 54.43 9.30 45 170100 82550 90375752
Taste disorder 53.85 9.30 24 170121 61522 90396780
Prescribed underdose 53.09 9.30 38 170107 74981 90383321
Seizure 52.74 9.30 477 169668 152152 90306150
Cushingoid 52.39 9.30 80 170065 10315 90447987
Renal function test abnormal 52.25 9.30 66 170079 7125 90451177
Rash 51.86 9.30 1120 169025 794980 89663322
Drug dependence 51.46 9.30 146 169999 29181 90429121
Prescribed overdose 50.94 9.30 65 170080 97560 90360742
Adverse event 50.77 9.30 89 170056 117329 90340973
Somatic symptom disorder 50.76 9.30 46 170099 3395 90454907
Drooling 50.51 9.30 52 170093 4494 90453808
Extrapyramidal disorder 50.20 9.30 101 170044 16202 90442100
X-ray abnormal 49.76 9.30 12 170133 45412 90412890
Febrile neutropenia 49.70 9.30 143 170002 158206 90300096
Dissociation 49.37 9.30 62 170083 6653 90451649
Infection susceptibility increased 49.31 9.30 48 170097 3878 90454424
Mental disorder 49.21 9.30 153 169992 32165 90426137
Conjunctivitis 48.88 9.30 135 170010 26571 90431731
Multiple drug therapy 48.83 9.30 63 170082 6946 90451356
Parosmia 48.40 9.30 63 170082 7006 90451296
Sacroiliitis 48.22 9.30 49 170096 4170 90454132
Creatinine renal clearance increased 46.72 9.30 43 170102 3238 90455064
Crystal nephropathy 45.89 9.30 28 170117 1123 90457179
Disease progression 45.88 9.30 146 169999 156469 90301833
Visual impairment 44.88 9.30 412 169733 131953 90326349
Anaemia 44.61 9.30 435 169710 352367 90105935
Retinitis 44.47 9.30 9 170136 38449 90419853
Lupus-like syndrome 44.41 9.30 18 170127 48828 90409474
C-reactive protein 44.14 9.30 4 170141 31363 90426939
Incontinence 43.50 9.30 85 170060 13350 90444952
Heart sounds 43.50 9.30 27 170118 1117 90457185
Nail disorder 43.02 9.30 29 170116 59038 90399264
Multiple sclerosis relapse 42.65 9.30 203 169942 52102 90406200
Paralysis 42.62 9.30 77 170068 11401 90446901
Osteoarthritis 42.32 9.30 206 169939 195524 90262778
Product quality issue 42.24 9.30 52 170093 79273 90379029
Allergy to chemicals 41.82 9.30 43 170102 3711 90454591
Tenderness 41.65 9.30 128 170017 26740 90431562
Akathisia 41.61 9.30 75 170070 11084 90447218
Urticaria 41.49 9.30 381 169764 312353 90145949
Oesophageal pain 41.48 9.30 46 170099 4328 90453974
Product use issue 41.19 9.30 408 169737 329511 90128791
Oedema peripheral 41.17 9.30 299 169846 257616 90200686
Prolonged expiration 41.17 9.30 27 170118 1230 90457072
Therapeutic product ineffective 41.08 9.30 35 170110 2379 90455923
Sciatica 41.03 9.30 80 170065 101302 90357000
CFTR gene mutation 41.00 9.30 16 170129 233 90458069
Menstrual disorder 40.94 9.30 54 170091 6084 90452218
Fat embolism syndrome 40.86 9.30 11 170134 42 90458260
Dyskinesia 40.80 9.30 156 169989 36378 90421924
Tension 40.70 9.30 42 170103 3640 90454662
Pregnancy 40.64 9.30 34 170111 62013 90396289
Corneal reflex decreased 40.38 9.30 17 170128 304 90457998
Mood swings 40.24 9.30 107 170038 20595 90437707
Oesophageal spasm 40.18 9.30 40 170105 3321 90454981
Synovial cyst 40.07 9.30 76 170069 11676 90446626
Joint effusion 39.46 9.30 103 170042 19607 90438695
Subarachnoid haemorrhage 39.43 9.30 97 170048 17807 90440495
Muscle disorder 39.35 9.30 50 170095 5429 90452873
Bezoar 39.26 9.30 36 170109 2698 90455604
Pulmonary eosinophilia 38.73 9.30 17 170128 338 90457964
Nasopharyngitis 38.62 9.30 535 169610 406569 90051733
Pituitary tumour benign 38.53 9.30 32 170113 2100 90456202
Cellulitis 38.21 9.30 298 169847 91039 90367263
Back injury 38.02 9.30 20 170125 46602 90411700
Clear cell renal cell carcinoma 37.83 9.30 28 170117 1552 90456750
Thrombocytopenia 37.81 9.30 233 169912 208492 90249810
Intentional product use issue 37.80 9.30 245 169900 216647 90241655
Muscle rigidity 37.50 9.30 83 170062 14226 90444076
Exostosis 37.48 9.30 27 170118 53107 90405195
Autonomic dysreflexia 37.37 9.30 17 170128 369 90457933
Psychotic disorder due to a general medical condition 36.98 9.30 15 170130 243 90458059
Anti-cyclic citrullinated peptide antibody 36.92 9.30 4 170141 27217 90431085
Aspartate aminotransferase increased 36.85 9.30 87 170058 102850 90355452
Drug tolerance decreased 36.17 9.30 8 170137 32122 90426180
Wheezing 36.10 9.30 280 169865 237800 90220502
Stress 35.97 9.30 269 169876 81126 90377176
Glucose tolerance impaired 35.47 9.30 58 170087 7927 90450375
Restlessness 35.45 9.30 147 169998 35573 90422729
Hyperthermia 35.44 9.30 67 170078 10268 90448034
Onychomycosis 35.26 9.30 13 170132 37363 90420939
Cyanosis 35.26 9.30 98 170047 19357 90438945
Coeliac disease 35.12 9.30 20 170125 44590 90413712
Irritability 34.80 9.30 146 169999 35516 90422786
Transient ischaemic attack 34.79 9.30 167 169978 43009 90415293
Inflammation 34.66 9.30 195 169950 178397 90279905
Respiratory arrest 34.58 9.30 139 170006 33172 90425130
Multiple sclerosis 34.55 9.30 123 170022 27717 90430585
Myalgia 34.38 9.30 490 169655 174635 90283667
Hot flush 34.32 9.30 210 169935 59278 90399024
Liver disorder 34.17 9.30 115 170030 121154 90337148
Cestode infection 34.14 9.30 15 170130 299 90458003
Sinus tachycardia 33.71 9.30 124 170021 28389 90429913
Telangiectasia congenital 33.48 9.30 8 170137 16 90458286
Neuroleptic malignant syndrome 33.47 9.30 82 170063 15014 90443288
Libido increased 33.24 9.30 27 170118 1717 90456585
Malaise 33.15 9.30 1380 168765 584606 89873696
Antinuclear antibody positive 33.05 9.30 61 170084 9180 90449122
Back pain 33.00 9.30 804 169341 316371 90141931
Accidental overdose 32.63 9.30 122 170023 28151 90430151
Circulatory collapse 32.61 9.30 112 170033 24792 90433510
Cervix neoplasm 32.48 9.30 13 170132 203 90458099
Small fibre neuropathy 32.47 9.30 19 170126 705 90457597
Hospitalisation 32.44 9.30 127 170018 127973 90330329
Bone erosion 32.39 9.30 31 170114 52990 90405312
Intentional product misuse 31.95 9.30 282 169863 89322 90368980
Abdominal pain 31.78 9.30 970 169175 394751 90063551
Sopor 31.55 9.30 110 170035 24534 90433768
Bradycardia 31.52 9.30 267 169878 83580 90374722
Macular degeneration 31.39 9.30 16 170129 37954 90420348
Paradoxical drug reaction 31.38 9.30 46 170099 5720 90452582
Device expulsion 31.24 9.30 19 170126 40867 90417435
Dysarthria 31.22 9.30 192 169953 54290 90404012
Insomnia 31.08 9.30 833 169312 332641 90125661
Labelled drug-drug interaction issue 31.01 9.30 29 170116 2229 90456073
Liver function test increased 30.95 9.30 71 170074 84784 90373518
Soft tissue injury 30.93 9.30 28 170117 2064 90456238
Myofascial pain syndrome 30.92 9.30 33 170112 2974 90455328
Sensory loss 30.76 9.30 89 170056 17986 90440316
Vestibular migraine 30.55 9.30 13 170132 239 90458063
Persistent genital arousal disorder 30.42 9.30 18 170127 682 90457620
Lethargy 30.40 9.30 213 169932 62926 90395376
Respiration abnormal 30.31 9.30 54 170091 7909 90450393
Sternal fracture 30.24 9.30 32 170113 2855 90455447
Eye pruritus 30.03 9.30 121 170024 28906 90429396
Malignant neoplasm progression 29.66 9.30 102 170043 106768 90351534
Disorientation 29.53 9.30 162 169983 43952 90414350
Laryngitis 29.49 9.30 31 170114 50722 90407580
Septic shock 29.44 9.30 72 170073 84088 90374214
Hostility 28.94 9.30 28 170117 2245 90456057
Wrist deformity 28.91 9.30 33 170112 3205 90455097
Ventricular arrhythmia 28.80 9.30 38 170107 4283 90454019
Product dispensing error 28.64 9.30 68 170077 12205 90446097
Adverse reaction 28.60 9.30 10 170135 29702 90428600
Erdheim-Chester disease 28.56 9.30 9 170136 66 90458236
Walking aid user 27.83 9.30 16 170129 35490 90422812
Hypoaesthesia oral 27.70 9.30 78 170067 15522 90442780
Concussion 27.58 9.30 63 170082 11028 90447274
Diaphragmatic rupture 27.46 9.30 12 170133 236 90458066
Areflexia 27.29 9.30 34 170111 3619 90454683
Migraine with aura 27.25 9.30 32 170113 3204 90455098
Depressive symptom 27.10 9.30 41 170104 5244 90453058
Hyperlactacidaemia 26.99 9.30 36 170109 4100 90454202
Finger deformity 26.99 9.30 14 170131 32883 90425419
Vascular malformation 26.71 9.30 17 170128 735 90457567
Lymphoedema 26.65 9.30 71 170074 13682 90444620
Frequent bowel movements 26.62 9.30 41 170104 56894 90401408
Renal mass 26.57 9.30 28 170117 2487 90455815
Maternal exposure timing unspecified 26.55 9.30 5 170140 22478 90435824
Mania 26.44 9.30 72 170073 14052 90444250
Rheumatoid arthritis 25.64 9.30 503 169642 362111 90096191
Paranasal cyst 25.56 9.30 17 170128 793 90457509
Forced expiratory volume decreased 25.55 9.30 42 170103 5766 90452536
Injection site reaction 25.47 9.30 88 170057 91992 90366310
Coma scale abnormal 25.17 9.30 41 170104 5585 90452717
Hepatitis 25.15 9.30 60 170085 70679 90387623
Nodule 25.07 9.30 108 170037 26578 90431724
Post-traumatic neck syndrome 24.81 9.30 27 170118 2487 90455815
Biliary sepsis 24.79 9.30 18 170127 968 90457334
Bone marrow failure 24.58 9.30 15 170130 32206 90426096
Neutrophil count decreased 24.39 9.30 62 170083 71470 90386832
Lung disorder 24.27 9.30 173 169972 149710 90308592
Diet failure 24.16 9.30 7 170138 37 90458265
Mood altered 24.13 9.30 79 170066 17065 90441237
Cerebellar stroke 24.11 9.30 13 170132 411 90457891
Road traffic accident 24.00 9.30 112 170033 107514 90350788
High grade B-cell lymphoma Burkitt-like lymphoma recurrent 23.95 9.30 8 170137 72 90458230
Pulseless electrical activity 23.62 9.30 52 170093 8880 90449422
Ulcer haemorrhage 23.44 9.30 10 170135 26311 90431991
Suspected suicide 23.40 9.30 54 170091 9514 90448788
Hyperlipidaemia 23.29 9.30 95 170050 22821 90435481
CYP3A4 polymorphism 23.21 9.30 8 170137 80 90458222
Premenstrual syndrome 23.18 9.30 16 170129 794 90457508
Therapy non-responder 23.01 9.30 156 169989 136548 90321754
Osteoporosis 23.00 9.30 98 170047 96433 90361869
Impaired quality of life 22.77 9.30 95 170050 23049 90435253
Impaired reasoning 22.76 9.30 9 170136 136 90458166
Sensitivity to weather change 22.57 9.30 51 170094 8863 90449439
Hyperaesthesia 22.53 9.30 57 170088 10645 90447657
Eye irritation 22.22 9.30 124 170021 33854 90424448
Limb injury 21.96 9.30 117 170028 31391 90426911
Hepatic function abnormal 21.96 9.30 33 170112 46255 90412047
Psychotic symptom 21.87 9.30 24 170121 2232 90456070
Postural orthostatic tachycardia syndrome 21.73 9.30 24 170121 2248 90456054
Brain stem microhaemorrhage 21.68 9.30 6 170139 26 90458276
Headache 21.61 9.30 1890 168255 860856 89597446
Choanal stenosis 21.50 9.30 6 170139 27 90458275
Vitamin B12 decreased 21.49 9.30 37 170108 5273 90453029
Chondropathy 21.42 9.30 25 170120 2487 90455815
Disability 21.38 9.30 27 170118 40718 90417584
Respiratory acidosis 21.17 9.30 47 170098 8072 90450230
Immune thrombocytopenia 21.14 9.30 64 170081 13262 90445040
Arrhythmia 21.08 9.30 144 170001 42188 90416114
Nail injury 21.06 9.30 15 170130 783 90457519
Eyelid myoclonus 20.92 9.30 8 170137 110 90458192
Cerebellar microhaemorrhage 20.82 9.30 6 170139 31 90458271
Pneumonia 20.68 9.30 983 169162 637076 89821226
Aptyalism 20.60 9.30 14 170131 677 90457625
Anti-neutrophil cytoplasmic antibody positive vasculitis 20.50 9.30 31 170114 3962 90454340
Epilepsy 20.49 9.30 82 170063 82124 90376178
Psychotic disorder 20.44 9.30 114 170031 31116 90427186
Chronic idiopathic pain syndrome 20.39 9.30 7 170138 69 90458233
Tubulointerstitial nephritis and uveitis syndrome 20.26 9.30 10 170135 262 90458040
Naevus flammeus 20.10 9.30 8 170137 123 90458179
Dental restoration failure 20.06 9.30 17 170128 1147 90457155
Dry eye 19.97 9.30 181 169964 57750 90400552
Femoral artery dissection 19.93 9.30 6 170139 37 90458265
Purpura 19.82 9.30 67 170078 14711 90443591
Magnesium deficiency 19.79 9.30 14 170131 723 90457579
Anterograde amnesia 19.75 9.30 13 170132 596 90457706
Rectal cancer metastatic 19.65 9.30 10 170135 280 90458022
Pancreatitis relapsing 19.53 9.30 18 170127 1358 90456944
Blood creatinine increased 19.50 9.30 111 170034 101275 90357027
Subclavian artery embolism 19.50 9.30 5 170140 15 90458287
Alanine aminotransferase increased 19.44 9.30 136 170009 118202 90340100
Enlarged uvula 19.23 9.30 9 170136 209 90458093
Numb chin syndrome 19.04 9.30 6 170139 44 90458258
Cardiac failure congestive 19.01 9.30 108 170037 98586 90359716
Product use in unapproved indication 19 9.30 792 169353 335444 90122858
Eyelid exfoliation 18.96 9.30 10 170135 302 90458000
Pharyngeal swelling 18.93 9.30 51 170094 9893 90448409
Urinary incontinence 18.83 9.30 128 170017 37438 90420864
Appetite disorder 18.56 9.30 48 170097 9085 90449217
Cardiogenic shock 18.54 9.30 93 170052 24375 90433927
Hepatic cirrhosis 18.49 9.30 59 170086 63194 90395108
Substance-induced psychotic disorder 18.47 9.30 25 170120 2887 90455415
Thymus disorder 18.43 9.30 10 170135 320 90457982
Drug-induced liver injury 18.40 9.30 97 170048 90221 90368081
Mastoiditis 18.37 9.30 19 170126 1651 90456651
Hyperprolactinaemia 18.36 9.30 35 170110 5398 90452904
Craniorachischisis 18.35 9.30 4 170141 4 90458298
Visual snow syndrome 18.27 9.30 6 170139 51 90458251
Poliomyelitis 18.16 9.30 6 170139 52 90458250
Flat affect 17.99 9.30 19 170126 1692 90456610
Genital herpes 17.93 9.30 21 170124 2097 90456205
Treatment failure 17.89 9.30 434 169711 303494 90154808
Oral herpes 17.87 9.30 116 170029 33408 90424894
SLE arthritis 17.83 9.30 13 170132 704 90457598
Iron binding capacity total decreased 17.72 9.30 11 170134 455 90457847
Communication disorder 17.69 9.30 26 170119 3240 90455062
Skin discolouration 17.66 9.30 143 170002 44172 90414130
Skin necrosis 17.56 9.30 5 170140 16936 90441366
Panniculitis 17.54 9.30 3 170142 14455 90443847
Cardiac failure 17.42 9.30 127 170018 109369 90348933
Blood creatine phosphokinase 17.40 9.30 8 170137 178 90458124
Sinus pain 17.33 9.30 34 170111 5355 90452947
Ear haemorrhage 17.27 9.30 18 170127 1578 90456724
Female genital tract fistula 17.22 9.30 6 170139 17862 90440440
Polymenorrhoea 17.19 9.30 17 170128 1400 90456902
Atrial fibrillation 17.17 9.30 164 169981 133447 90324855
Synovial disorder 17.15 9.30 25 170120 3093 90455209
Vaccination site oedema 17.09 9.30 4 170141 7 90458295
Vaccination site bruising 17.09 9.30 4 170141 7 90458295
Drug hypersensitivity 16.89 9.30 705 169440 462904 89995398
Poor venous access 16.81 9.30 77 170068 19450 90438852
Proctitis 16.77 9.30 4 170141 15255 90443047
Foetal death 16.73 9.30 9 170136 20714 90437588
Immunodeficiency 16.73 9.30 35 170110 43199 90415103
Antidepressant drug level increased 16.69 9.30 10 170135 388 90457914
Enthesopathy 16.68 9.30 47 170098 9357 90448945
Hepatic enzyme decreased 16.53 9.30 14 170131 944 90457358
Pupillary reflex impaired 16.37 9.30 22 170123 2523 90455779
Ankylosing spondylitis 16.27 9.30 58 170087 13075 90445227
Viral diarrhoea 16.19 9.30 8 170137 210 90458092
Abnormal loss of weight 16.13 9.30 38 170107 6785 90451517
Congenital hypoplasia of depressor angularis oris muscle 16.13 9.30 6 170139 76 90458226
Cystitis interstitial 16.12 9.30 18 170127 1706 90456596
Mental status changes 16.12 9.30 141 170004 44538 90413764
Adiposis dolorosa 16.12 9.30 9 170136 305 90457997
Spinal osteoarthritis 16.11 9.30 75 170070 19073 90439229
Pulmonary toxicity 16.11 9.30 53 170092 11478 90446824
Underdose 16.06 9.30 50 170095 53967 90404335
Quality of life decreased 16.03 9.30 54 170091 11835 90446467
Dysphemia 16 9.30 24 170121 3046 90455256
Mental impairment 15.96 9.30 68 170077 16652 90441650
Illness 15.93 9.30 229 169916 81740 90376562
Acquired diaphragmatic eventration 15.91 9.30 11 170134 547 90457755
Atelectasis 15.91 9.30 89 170056 24320 90433982
Lichen sclerosus 15.89 9.30 16 170129 1347 90456955
Child maltreatment syndrome 15.84 9.30 3 170142 0 90458302
Pyrexia 15.81 9.30 1048 169097 659437 89798865
Infrapatellar fat pad inflammation 15.75 9.30 8 170137 223 90458079
Maternal condition affecting foetus 15.75 9.30 8 170137 223 90458079
Dysphonia 15.51 9.30 184 169961 62900 90395402
Heart rate 15.40 9.30 8 170137 234 90458068
Ulcer 15.28 9.30 110 170035 32772 90425530
Cytokine release syndrome 15.25 9.30 18 170127 27955 90430347
Movement disorder 15.22 9.30 100 170045 28919 90429383
Sleep apnoea syndrome 15.22 9.30 107 170038 31640 90426662
Acute kidney injury 15.11 9.30 741 169404 319646 90138656
Parkinsonian rest tremor 15.09 9.30 7 170138 159 90458143
Normal newborn 15.05 9.30 13 170132 23349 90434953
Asthenia 15.04 9.30 834 169311 532917 89925385
Mouth swelling 15.02 9.30 33 170112 5629 90452673
No adverse event 15.00 9.30 71 170074 67911 90390391
Contusion 14.98 9.30 358 169787 250858 90207444
Metabolic acidosis 14.86 9.30 165 169980 55511 90402791
Term birth 14.82 9.30 7 170138 166 90458136
Hypoglycaemia 14.73 9.30 198 169947 69650 90388652
Myoglobin urine 14.71 9.30 4 170141 16 90458286
Mitochondrial encephalomyopathy 14.69 9.30 6 170139 99 90458203
Hyperacusis 14.69 9.30 22 170123 2789 90455513
Delusion 14.56 9.30 58 170087 13782 90444520
Umbilical cord short 14.52 9.30 4 170141 17 90458285
Vulvovaginal swelling 14.49 9.30 12 170133 784 90457518
Laboratory test abnormal 14.48 9.30 36 170109 41818 90416484
Rash papular 14.47 9.30 76 170069 20279 90438023
Slow speech 14.46 9.30 18 170127 1915 90456387
Sputum discoloured 14.40 9.30 76 170069 20315 90437987
C-reactive protein increased 14.24 9.30 247 169898 181142 90277160
Arterial occlusive disease 14.21 9.30 3 170142 12443 90445859
Environmental exposure 14.11 9.30 6 170139 110 90458192
Genital infection female 14.07 9.30 6 170139 111 90458191
Premature labour 14.03 9.30 56 170089 13320 90444982
Postictal psychosis 14.02 9.30 6 170139 112 90458190
Calcinosis 13.95 9.30 21 170124 2674 90455628
Oxalosis 13.92 9.30 5 170140 57 90458245
Mass 13.84 9.30 62 170083 15515 90442787
Skin burning sensation 13.79 9.30 73 170072 19538 90438764
Internal carotid artery deformity 13.77 9.30 3 170142 3 90458299
Diaphragmatic paralysis 13.74 9.30 11 170134 685 90457617
Procedural anxiety 13.73 9.30 12 170133 844 90457458
Naevus haemorrhage 13.68 9.30 6 170139 119 90458183
Myocardial infarction 13.65 9.30 277 169868 105695 90352607
Pain in jaw 13.64 9.30 144 170001 47841 90410461
Burning feet syndrome 13.64 9.30 6 170139 120 90458182
Leukopenia 13.64 9.30 122 170023 100588 90357714
White blood cell count decreased 13.63 9.30 226 169919 166883 90291419
Hypoglycaemic seizure 13.58 9.30 10 170135 550 90457752
Pulse absent 13.54 9.30 33 170112 6022 90452280
Vaccination site pruritus 13.52 9.30 4 170141 23 90458279
Red blood cell sedimentation rate decreased 13.51 9.30 13 170132 1035 90457267
Abortion spontaneous 13.42 9.30 54 170091 54002 90404300
Judgement impaired 13.39 9.30 12 170133 873 90457429
Foot deformity 13.34 9.30 62 170083 59589 90398713
Mouth ulceration 13.32 9.30 124 170021 39850 90418452
Panic attack 13.31 9.30 90 170055 26275 90432027
Vertebral artery hypoplasia 13.31 9.30 3 170142 4 90458298
Sleep disorder 13.29 9.30 277 169868 197753 90260549
Product administration error 13.22 9.30 90 170055 26333 90431969
Disorganised speech 13.22 9.30 17 170128 1868 90456434
Junctional ectopic tachycardia 13.19 9.30 7 170138 214 90458088
Allergic sinusitis 13.19 9.30 18 170127 2095 90456207
Pharyngeal oedema 13.14 9.30 56 170089 13715 90444587
Thoracic radiculopathy 13.11 9.30 4 170141 26 90458276
Antisocial behaviour 13.08 9.30 10 170135 582 90457720
HLA marker study positive 13.05 9.30 7 170138 219 90458083
Hereditary angioedema 13.04 9.30 43 170102 9322 90448980
Infusion site reaction 13.01 9.30 10 170135 19029 90439273
Laryngeal dyspnoea 12.93 9.30 7 170138 223 90458079
Middle insomnia 12.93 9.30 64 170081 16687 90441615
Diabetes mellitus 12.91 9.30 182 169963 64693 90393609
Injection site swelling 12.91 9.30 63 170082 59776 90398526
Breast pain 12.90 9.30 46 170099 10372 90447930
Aphasia 12.89 9.30 130 170015 42682 90415620
Hypohidrosis 12.86 9.30 5 170140 72 90458230
Systemic infection 12.86 9.30 28 170117 4747 90453555
Oesophageal irritation 12.84 9.30 8 170137 333 90457969
Decreased appetite 12.79 9.30 577 169568 375963 90082339
IIIrd nerve paresis 12.67 9.30 6 170139 143 90458159
Peripheral nerve lesion 12.66 9.30 9 170136 468 90457834
Intestinal ischaemia 12.56 9.30 41 170104 8842 90449460
Good syndrome 12.56 9.30 3 170142 6 90458296
Heliotrope rash 12.52 9.30 7 170138 238 90458064
General symptom 12.40 9.30 6 170139 14662 90443640
Chemical burns of eye 12.33 9.30 5 170140 81 90458221
Onychophagia 12.33 9.30 5 170140 81 90458221
Lymphocytosis 12.29 9.30 21 170124 2976 90455326
Metastases to central nervous system 12.26 9.30 9 170136 17533 90440769
Bruxism 12.22 9.30 26 170119 4337 90453965
Blood uric acid abnormal 12.20 9.30 6 170139 156 90458146
Injection site erythema 12.19 9.30 122 170023 98380 90359922
Urticaria aquagenic 12.18 9.30 4 170141 34 90458268
Muscle contracture 12.11 9.30 16 170129 1805 90456497
Nail bed tenderness 12.09 9.30 8 170137 370 90457932
Mitochondrial toxicity 12.08 9.30 10 170135 653 90457649
Ear infection 12.05 9.30 79 170066 69696 90388606
Plasma cell myeloma 11.99 9.30 38 170107 40790 90417512
Hypoventilation 11.99 9.30 29 170116 5267 90453035
Post-traumatic stress disorder 11.99 9.30 34 170111 6794 90451508
Axonal neuropathy 11.96 9.30 13 170132 1196 90457106
Secondary adrenocortical insufficiency 11.91 9.30 18 170127 2300 90456002
Rash vesicular 11.88 9.30 10 170135 18187 90440115
Autonomic neuropathy 11.83 9.30 14 170131 1413 90456889
Bursitis 11.76 9.30 175 169970 131479 90326823
Rectal haemorrhage 11.75 9.30 99 170046 82645 90375657
Ear pain 11.74 9.30 62 170083 57640 90400662
Oral pain 11.72 9.30 103 170042 32580 90425722
Urticaria cholinergic 11.69 9.30 4 170141 39 90458263
Oral mucosal blistering 11.69 9.30 34 170111 6890 90451412
Nasal polyps 11.67 9.30 3 170142 10877 90447425
Meniscus injury 11.63 9.30 38 170107 8199 90450103
Product selection error 11.63 9.30 7 170138 274 90458028
Nocturia 11.62 9.30 44 170101 10211 90448091
Disseminated intravascular coagulation 11.59 9.30 14 170131 21524 90436778
Device wireless communication issue 11.55 9.30 5 170140 96 90458206
Hyperreflexia 11.54 9.30 33 170112 6624 90451678
Menstruation delayed 11.51 9.30 17 170128 2128 90456174
Alcohol poisoning 11.50 9.30 16 170129 1896 90456406
Abulia 11.50 9.30 10 170135 699 90457603
Blood sodium decreased 11.49 9.30 90 170055 27523 90430779
Electrocardiogram QRS complex shortened 11.49 9.30 9 170136 543 90457759
Polyp 11.46 9.30 36 170109 7608 90450694
Postmortem blood drug level increased 11.42 9.30 10 170135 705 90457597
Metastases to liver 11.42 9.30 23 170122 28784 90429518
Joint dislocation 11.41 9.30 44 170101 44538 90413764
Bipolar disorder 11.41 9.30 40 170105 8945 90449357
Diabetic ketosis 11.36 9.30 9 170136 552 90457750
Hypochromic anaemia 11.36 9.30 17 170128 2154 90456148
Foramen magnum stenosis 11.32 9.30 6 170139 183 90458119
Neonatal pneumonia 11.26 9.30 4 170141 44 90458258
Aorta hypoplasia 11.23 9.30 6 170139 186 90458116
Bladder disorder 11.22 9.30 45 170100 10727 90447575
Herpes zoster meningoencephalitis 11.21 9.30 8 170137 419 90457883
Intestinal adenocarcinoma 11.18 9.30 6 170139 188 90458114
Conduction disorder 11.17 9.30 15 170130 1720 90456582
Bradykinesia 11.14 9.30 33 170112 6755 90451547
Therapeutic response changed 11.05 9.30 13 170132 1304 90456998
Anuria 11.00 9.30 56 170089 14762 90443540
Multiple organ dysfunction syndrome 11.00 9.30 79 170066 68257 90390045
Open angle glaucoma 10.99 9.30 7 170138 303 90457999
Cardiac death 10.99 9.30 9 170136 579 90457723
Micturition urgency 10.97 9.30 46 170099 11187 90447115
Phonophobia 10.89 9.30 8 170137 438 90457864
Bronchoalveolar lavage abnormal 10.89 9.30 6 170139 198 90458104
Trigeminal neuralgia 10.87 9.30 24 170121 4107 90454195
Syncope 10.84 9.30 326 169819 132337 90325965
Poikiloderma 10.83 9.30 7 170138 311 90457991
Hepatocellular injury 10.77 9.30 92 170053 28866 90429436
Renal failure 10.74 9.30 177 169968 130830 90327472
Pharyngeal mass 10.71 9.30 7 170138 317 90457985
White blood cell count increased 10.69 9.30 78 170067 67163 90391139
Pneumocystis jirovecii pneumonia 10.66 9.30 15 170130 21601 90436701
Psychomotor retardation 10.60 9.30 26 170119 4763 90453539
Unevaluable event 10.57 9.30 60 170085 54788 90403514
Acute myeloid leukaemia 10.50 9.30 14 170131 20626 90437676
Central obesity 10.49 9.30 13 170132 1377 90456925
Sciatic nerve neuropathy 10.47 9.30 8 170137 465 90457837
Norovirus infection 10.46 9.30 15 170130 1829 90456473
Product monitoring error 10.41 9.30 25 170120 4519 90453783
Acquired cystic kidney disease 10.39 9.30 4 170141 56 90458246
Pharyngeal enanthema 10.33 9.30 4 170141 57 90458245
Bacteriuria 10.28 9.30 12 170133 1194 90457108
Intracranial hypotension 10.27 9.30 7 170138 340 90457962
Spondylitis 10.27 9.30 7 170138 14171 90444131
Hypomagnesaemia 10.21 9.30 107 170038 35481 90422821
Terminal insomnia 10.21 9.30 12 170133 1203 90457099
Vitreous detachment 10.20 9.30 17 170128 2361 90455941
Vertebral lateral recess stenosis 10.18 9.30 7 170138 345 90457957
Cystitis 10.17 9.30 179 169966 66539 90391763
Tachyphylaxis 10.16 9.30 7 170138 346 90457956
Long QT syndrome 10.11 9.30 23 170122 4014 90454288
Allodynia 10.11 9.30 11 170134 1013 90457289
Hyponatraemia 10.08 9.30 325 169820 133213 90325089
Hypoalbuminaemia 10.06 9.30 9 170136 15888 90442414
Broad ligament tear 10.04 9.30 3 170142 18 90458284
Genital prolapse 10.02 9.30 4 170141 62 90458240
Asterixis 9.99 9.30 14 170131 1671 90456631
Jaw fracture 9.99 9.30 18 170127 2660 90455642
Sepsis 9.97 9.30 259 169886 179555 90278747
Personality disorder 9.93 9.30 48 170097 12396 90445906
Sensory disturbance 9.91 9.30 56 170089 15357 90442945
Osteoarthropathy 9.90 9.30 7 170138 361 90457941
Cluster headache 9.88 9.30 10 170135 847 90457455
Red blood cell sedimentation rate abnormal 9.88 9.30 19 170126 24185 90434117
Febrile bone marrow aplasia 9.86 9.30 3 170142 9735 90448567
Decreased interest 9.83 9.30 24 170121 4383 90453919
Glomerulonephritis minimal lesion 9.83 9.30 7 170138 365 90457937
Myelodysplastic syndrome 9.82 9.30 15 170130 20888 90437414
Anal incontinence 9.81 9.30 58 170087 16172 90442130
Cerebral atrophy 9.80 9.30 28 170117 5618 90452684
Ligamentum flavum hypertrophy 9.75 9.30 7 170138 370 90457932
Nerve injury 9.71 9.30 44 170101 11062 90447240
Iliotibial band syndrome 9.70 9.30 7 170138 373 90457929
Oropharyngeal pain 9.66 9.30 284 169861 114903 90343399
Ovarian adhesion 9.64 9.30 3 170142 21 90458281
Optic nerve infarction 9.64 9.30 3 170142 21 90458281
Hypothermia 9.63 9.30 56 170089 15519 90442783
Blood creatine phosphokinase decreased 9.61 9.30 9 170136 693 90457609
Kyphoscoliosis 9.61 9.30 8 170137 527 90457775
Stoma site discharge 9.59 9.30 15 170130 1974 90456328
Inappropriate schedule of product administration 9.59 9.30 358 169787 149575 90308727
Drug intolerance 9.57 9.30 717 169428 446874 90011428
Eye degenerative disorder 9.52 9.30 3 170142 22 90458280
Vertebral artery dissection 9.51 9.30 5 170140 150 90458152
Tooth abscess 9.50 9.30 58 170087 16355 90441947
Post viral fatigue syndrome 9.48 9.30 6 170139 257 90458045
Pachymeningitis 9.48 9.30 6 170139 257 90458045
Pleural disorder 9.46 9.30 9 170136 707 90457595
Hypersomnia 9.42 9.30 71 170074 21460 90436842
Transferrin decreased 9.41 9.30 7 170138 391 90457911
Linear IgA disease 9.41 9.30 16 170129 2258 90456044
Haemorrhage 9.40 9.30 84 170061 69285 90389017
Peritonitis 9.39 9.30 14 170131 19691 90438611
Miosis 9.39 9.30 39 170106 9445 90448857
Hypertonia 9.37 9.30 26 170119 5129 90453173
Therapeutic reaction time decreased 9.34 9.30 21 170124 3637 90454665
Neoplasm malignant 9.31 9.30 101 170044 33779 90424523

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Serotonin syndrome 345.55 11.32 285 58055 25560 42537435
Toxicity to various agents 341.17 11.32 877 57463 228259 42334736
Migraine 322.66 11.32 272 58068 25142 42537853
Completed suicide 243.35 11.32 457 57883 96008 42466987
Sedation 241.54 11.32 251 58089 30224 42532771
Nightmare 223.81 11.32 220 58120 24792 42538203
Hyperhidrosis 188.68 11.32 396 57944 90116 42472879
Cardiospasm 186.25 11.32 77 58263 1830 42561165
Coma 181.16 11.32 289 58051 53265 42509730
Tension headache 175.06 11.32 88 58252 3326 42559669
Palmoplantar keratoderma 167.44 11.32 75 58265 2179 42560816
Facial pain 162.19 11.32 90 58250 4170 42558825
Nephrolithiasis 156.28 11.32 221 58119 36609 42526386
Overdose 156.16 11.32 403 57937 104861 42458134
Pruritus genital 156.14 11.32 75 58265 2564 42560431
Drug abuse 153.25 11.32 399 57941 104372 42458623
Sleep terror 151.73 11.32 76 58264 2850 42560145
Atrial tachycardia 134.86 11.32 79 58261 4061 42558934
Carotid artery occlusion 131.30 11.32 78 58262 4116 42558879
Muscle twitching 131.09 11.32 117 58223 11663 42551332
Anosmia 128.39 11.32 83 58257 5093 42557902
Disturbance in attention 124.90 11.32 178 58162 29688 42533307
Coombs positive haemolytic anaemia 124.46 11.32 51 58289 1184 42561811
Immunisation 123.55 11.32 51 58289 1207 42561788
Pain of skin 105.62 11.32 88 58252 7992 42555003
Poisoning deliberate 101.71 11.32 95 58245 10039 42552956
Head discomfort 99.74 11.32 71 58269 5106 42557889
Intentional overdose 95.55 11.32 215 58125 51241 42511754
Lymphadenitis 95.45 11.32 53 58287 2458 42560537
Electrocardiogram QRS complex prolonged 94.47 11.32 72 58268 5751 42557244
Cerebral hypoperfusion 88.14 11.32 38 58302 1005 42561990
Hallucination 87.07 11.32 222 58118 57285 42505710
Diplopia 76.13 11.32 115 58225 20201 42542794
Disease progression 73.02 11.32 54 58286 143602 42419393
Memory impairment 72.03 11.32 190 58150 50032 42512963
Platelet count decreased 71.86 11.32 51 58289 138530 42424465
Cognitive disorder 68.19 11.32 147 58193 34025 42528970
Pericarditis 68.15 11.32 88 58252 13356 42549639
Vasculitis 65.93 11.32 102 58238 18292 42544703
Eye pruritus 64.70 11.32 79 58261 11333 42551662
Lip swelling 64.61 11.32 103 58237 18950 42544045
Subarachnoid haemorrhage 64.57 11.32 89 58251 14383 42548612
Amnesia 62.18 11.32 127 58213 28310 42534685
Confusional state 61.91 11.32 417 57923 167180 42395815
Anaemia 61.17 11.32 189 58151 280089 42282906
Migraine with aura 60.14 11.32 28 58312 891 42562104
Suicide attempt 58.73 11.32 167 58173 45933 42517062
Tinnitus 58.33 11.32 125 58215 28813 42534182
Ventricular tachycardia 58.19 11.32 128 58212 30032 42532963
Rash papular 57.83 11.32 76 58264 11735 42551260
Visual impairment 57.69 11.32 159 58181 42954 42520041
Blindness 55.29 11.32 93 58247 17885 42545110
Febrile neutropenia 53.93 11.32 108 58232 185595 42377400
Product used for unknown indication 53.03 11.32 28 58312 1173 42561822
Insomnia 50.27 11.32 305 58035 117948 42445047
Foetal disorder 50.05 11.32 26 58314 1053 42561942
Feeling abnormal 48.71 11.32 207 58133 69579 42493416
Intentional product misuse 48.26 11.32 190 58150 61710 42501285
Anxiety 47.40 11.32 301 58039 118259 42444736
Allodynia 46.88 11.32 25 58315 1069 42561926
Thrombocytopenia 46.09 11.32 122 58218 190157 42372838
White blood cell count decreased 45.90 11.32 50 58290 110346 42452649
Tachycardia 45.71 11.32 265 58075 100822 42462173
Palpitations 43.78 11.32 161 58179 50636 42512359
Substance abuse 43.13 11.32 57 58283 8848 42554147
Death 42.69 11.32 426 57914 470759 42092236
Neck pain 42.46 11.32 113 58227 29901 42533094
Neutropenia neonatal 42.19 11.32 22 58318 898 42562097
Brugada syndrome 42.15 11.32 23 58317 1030 42561965
Somnolence 40.61 11.32 331 58009 140774 42422221
Sepsis 40.26 11.32 139 58201 199195 42363800
Carbon dioxide abnormal 38.77 11.32 15 58325 298 42562697
Headache 37.55 11.32 496 57844 238873 42324122
Foetal exposure during pregnancy 37.50 11.32 146 58194 47165 42515830
Hyperthermia 37.28 11.32 64 58276 12510 42550485
Binocular eye movement disorder 35.64 11.32 14 58326 290 42562705
Colour blindness acquired 35.41 11.32 11 58329 109 42562886
Haemoglobin decreased 35.14 11.32 81 58259 132390 42430605
Multiple organ dysfunction syndrome 35.02 11.32 49 58291 96986 42466009
Renal failure 34.90 11.32 92 58248 143634 42419361
Haemolysis 34.11 11.32 53 58287 9536 42553459
Myoclonus 33.56 11.32 73 58267 16992 42546003
Patient dissatisfaction with treatment 33.15 11.32 10 58330 89 42562906
Pain 33.02 11.32 494 57846 244354 42318641
Heart rate increased 32.65 11.32 152 58188 53103 42509892
Transient ischaemic attack 32.56 11.32 111 58229 33628 42529367
Delusion of replacement 32.26 11.32 12 58328 213 42562782
Interstitial lung disease 31.01 11.32 37 58303 78425 42484570
Back pain 30.81 11.32 313 58027 141463 42421532
Cytomegalovirus infection 30.62 11.32 4 58336 32302 42530693
Hyperaesthesia 30.23 11.32 39 58301 5913 42557082
Salmonella bacteraemia 29.74 11.32 14 58326 457 42562538
Muscular weakness 29.72 11.32 206 58134 83292 42479703
Foetal growth restriction 29.02 11.32 36 58304 5247 42557748
Cerebellar stroke 28.55 11.32 15 58325 622 42562373
On and off phenomenon 28.24 11.32 29 58311 3438 42559557
Pleural effusion 27.75 11.32 57 58283 97109 42465886
Rash 27.74 11.32 244 58096 276710 42286285
Suicidal ideation 27.73 11.32 135 58205 48026 42514969
Depression 27.71 11.32 253 58087 111110 42451885
Neutrophil count decreased 27.15 11.32 28 58312 63387 42499608
Quality of life decreased 26.95 11.32 35 58305 5341 42557654
Mydriasis 26.48 11.32 45 58295 8725 42554270
Preterm premature rupture of membranes 25.51 11.32 8 58332 82 42562913
Withdrawal syndrome 25.49 11.32 60 58280 14715 42548280
Angioedema 25.13 11.32 120 58220 42357 42520638
Abdominal pain upper 24.95 11.32 196 58144 82413 42480582
Substance use 24.83 11.32 20 58320 1731 42561264
Pneumonia 24.06 11.32 420 57920 421729 42141266
Dysarthria 23.94 11.32 113 58227 39694 42523301
Oedema peripheral 23.51 11.32 101 58239 135975 42427020
Acute psychosis 23.22 11.32 21 58319 2128 42560867
HIV peripheral neuropathy 23.20 11.32 6 58334 28 42562967
Ascites 23.18 11.32 26 58314 56652 42506343
Intentional product use issue 23.12 11.32 173 58167 71660 42491335
Constipation 22.85 11.32 330 58010 161961 42401034
Hypertonia 22.67 11.32 31 58309 4970 42558025
Pulmonary embolism 22.41 11.32 86 58254 119526 42443469
Balance disorder 22.23 11.32 126 58214 47519 42515476
Onycholysis 22.21 11.32 15 58325 990 42562005
Alopecia 21.32 11.32 88 58252 29188 42533807
Alcoholic ketoacidosis 21.15 11.32 6 58334 42 42562953
Sopor 21.04 11.32 52 58288 13150 42549845
Agitation 20.76 11.32 155 58185 64159 42498836
Astigmatism 20.59 11.32 16 58324 1315 42561680
Sleep deficit 20.45 11.32 14 58326 945 42562050
Agoraphobia 20.17 11.32 9 58331 259 42562736
Hallucination, visual 20.14 11.32 69 58271 20951 42542044
Anticholinergic syndrome 20.13 11.32 17 58323 1572 42561423
Aggression 20.08 11.32 116 58224 44047 42518948
Blood bilirubin increased 20.03 11.32 17 58323 42235 42520760
Speech disorder 20.01 11.32 86 58254 29035 42533960
Drug dispensed to wrong patient 19.89 11.32 11 58329 506 42562489
Lipids increased 19.69 11.32 15 58325 1197 42561798
Post herpetic neuralgia 19.32 11.32 15 58325 1231 42561764
Femoral nerve palsy 19.27 11.32 6 58334 60 42562935
Drug withdrawal syndrome neonatal 19.25 11.32 27 58313 4434 42558561
Drug ineffective for unapproved indication 18.91 11.32 118 58222 46045 42516950
Diarrhoea 18.78 11.32 484 57856 460365 42102630
Hypomania 18.68 11.32 20 58320 2488 42560507
Urinary retention 18.62 11.32 110 58230 42104 42520891
Dry skin 18.23 11.32 121 58219 48217 42514778
Thrombosis 18.06 11.32 42 58298 68469 42494526
Depressed level of consciousness 18.05 11.32 120 58220 47850 42515145
Sitting disability 18.00 11.32 8 58332 228 42562767
Vascular pseudoaneurysm ruptured 17.83 11.32 10 58330 473 42562522
Chemical submission 17.77 11.32 6 58334 79 42562916
Venous angioma of brain 17.75 11.32 5 58335 34 42562961
Carbon dioxide decreased 17.58 11.32 18 58322 2126 42560869
Dizziness 17.57 11.32 456 57884 248798 42314197
Disseminated intravascular coagulation 17.55 11.32 6 58334 24788 42538207
Dumping syndrome 17.39 11.32 5 58335 37 42562958
Mucosal dryness 17.36 11.32 16 58324 1662 42561333
Blood lactate dehydrogenase increased 17.30 11.32 7 58333 26074 42536921
Behaviour disorder 17.22 11.32 33 58307 7021 42555974
Brain stem syndrome 17.14 11.32 11 58329 666 42562329
Respiratory failure 17.08 11.32 104 58236 128028 42434967
Infective aneurysm 16.97 11.32 13 58327 1046 42561949
Burning sensation 16.77 11.32 65 58275 20948 42542047
Low birth weight baby 16.71 11.32 40 58300 9915 42553080
Victim of crime 16.70 11.32 10 58330 535 42562460
Prostate cancer 16.65 11.32 22 58318 44621 42518374
Neurosis 16.56 11.32 7 58333 176 42562819
CADASIL 16.53 11.32 6 58334 99 42562896
Haematuria 16.42 11.32 34 58306 57765 42505230
Atrial fibrillation 16.25 11.32 118 58222 139475 42423520
Acute lung injury 16.14 11.32 15 58325 1574 42561421
General physical health deterioration 16.12 11.32 131 58209 151115 42411880
Aspartate aminotransferase increased 16.10 11.32 53 58287 77110 42485885
Delirium 16.06 11.32 125 58215 52394 42510601
Malignant neoplasm progression 16.06 11.32 85 58255 108315 42454680
Urticaria 16.04 11.32 50 58290 73986 42489009
Tonsillar disorder 16.02 11.32 9 58331 427 42562568
Medical device site dryness 15.97 11.32 4 58336 16 42562979
Dry age-related macular degeneration 15.90 11.32 6 58334 111 42562884
Bradyphrenia 15.88 11.32 27 58313 5235 42557760
Peripheral swelling 15.79 11.32 191 58149 90079 42472916
Adjustment disorder with disturbance of conduct 15.61 11.32 6 58334 117 42562878
Victim of homicide 15.57 11.32 7 58333 205 42562790
Pulmonary artery stenosis 15.56 11.32 8 58332 317 42562678
Hospitalisation 15.54 11.32 51 58289 74279 42488716
Sensorimotor disorder 15.53 11.32 9 58331 453 42562542
Miosis 15.48 11.32 47 58293 13399 42549596
Cyclic vomiting syndrome 15.39 11.32 5 58335 58 42562937
Bronchiectasis 15.35 11.32 3 58337 18016 42544979
Blood creatinine increased 15.34 11.32 88 58252 109915 42453080
Disease recurrence 15.26 11.32 11 58329 29667 42533328
Cardiac failure congestive 15.11 11.32 63 58277 85539 42477456
Velopharyngeal incompetence 14.92 11.32 4 58336 22 42562973
Pneumocystis jirovecii pneumonia 14.79 11.32 8 58332 25173 42537822
Anophthalmos 14.71 11.32 3 58337 3 42562992
Mast cell degranulation present 14.66 11.32 5 58335 68 42562927
Benzodiazepine drug level therapeutic 14.63 11.32 4 58336 24 42562971
Anaphylactic shock 14.52 11.32 7 58333 23510 42539485
Cardio-respiratory arrest 14.46 11.32 133 58207 58503 42504492
Liver disorder 14.31 11.32 20 58320 39624 42523371
Renal pain 14.25 11.32 21 58319 3606 42559389
Ventricular hypoplasia 14.22 11.32 5 58335 75 42562920
Neutropenia 14.19 11.32 190 58150 199241 42363754
Neuralgia 14.12 11.32 71 58269 25576 42537419
Pneumonia aspiration 14.12 11.32 117 58223 49961 42513034
Decreased appetite 14.11 11.32 183 58157 192954 42370041
Colour blindness 14.06 11.32 8 58332 389 42562606
Altered state of consciousness 14.06 11.32 78 58262 29181 42533814
Enterobacter pneumonia 13.92 11.32 9 58331 552 42562443
Loss of consciousness 13.87 11.32 190 58150 92164 42470831
Blindness transient 13.73 11.32 18 58322 2771 42560224
Nausea 13.71 11.32 669 57671 396130 42166865
Electric shock 13.70 11.32 6 58334 165 42562830
Feeling cold 13.69 11.32 44 58296 12929 42550066
Cardiotoxicity 13.68 11.32 31 58309 7414 42555581
Haemophagocytic lymphohistiocytosis 13.63 11.32 4 58336 18218 42544777
Type III immune complex mediated reaction 13.62 11.32 9 58331 573 42562422
Agitation neonatal 13.59 11.32 13 58327 1415 42561580
Pancytopenia 13.47 11.32 100 58240 117643 42445352
Blood urea increased 13.45 11.32 15 58325 32778 42530217
Weight decreased 13.42 11.32 202 58138 207746 42355249
Cough 13.29 11.32 168 58172 177935 42385060
Haemoptysis 13.25 11.32 27 58313 46140 42516855
Respiratory depression 13.18 11.32 56 58284 18812 42544183
Skull fracture 13.03 11.32 11 58329 1017 42561978
Therapeutic product effect decreased 13.00 11.32 95 58245 39055 42523940
Thoracic vertebral fracture 12.90 11.32 16 58324 2332 42560663
Product use in unapproved indication 12.85 11.32 337 58003 184119 42378876
Cytokine release syndrome 12.81 11.32 26 58314 44501 42518494
Maternal exposure during pregnancy 12.76 11.32 29 58311 6949 42556046
Hepatocellular injury 12.65 11.32 65 58275 23613 42539382
Drug resistance 12.64 11.32 17 58323 34231 42528764
Lid lag 12.64 11.32 3 58337 9 42562986
Drug interaction 12.55 11.32 465 57875 266534 42296461
Epistaxis 12.54 11.32 48 58292 66778 42496217
Hypoxia 12.54 11.32 51 58289 69735 42493260
Incorrect route of product administration 12.51 11.32 9 58331 24296 42538699
Drug dependence 12.31 11.32 75 58265 29019 42533976
Renal infarct 12.27 11.32 14 58326 1869 42561126
Tongue spasm 12.26 11.32 4 58336 47 42562948
Distal intestinal obstruction syndrome 12.25 11.32 8 58332 499 42562496
Abdominal discomfort 12.20 11.32 157 58183 75098 42487897
Clumsiness 12.17 11.32 14 58326 1886 42561109
Poisoning 12.16 11.32 46 58294 14653 42548342
Periodontitis 12.04 11.32 15 58325 2196 42560799
Hypohidrosis 11.93 11.32 6 58334 227 42562768
Hepatic enzyme increased 11.87 11.32 105 58235 45679 42517316
Generalised tonic-clonic seizure 11.80 11.32 69 58271 26310 42536685
Nystagmus 11.67 11.32 24 58316 5372 42557623
Suspected suicide 11.60 11.32 26 58314 6173 42556822
Diabetic autonomic neuropathy 11.60 11.32 3 58337 14 42562981
Neovascular age-related macular degeneration 11.60 11.32 6 58334 241 42562754
Pyrexia 11.58 11.32 432 57908 393610 42169385
Bursitis 11.48 11.32 26 58314 6218 42556777
Fluid retention 11.37 11.32 16 58324 31603 42531392

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 1219.25 9.60 2722 202084 477833 109906660
Completed suicide 799.17 9.60 1531 203275 240850 110143643
Sedation 699.90 9.60 750 204056 68933 110315560
Cognitive disorder 654.80 9.60 809 203997 86702 110297791
Serotonin syndrome 556.21 9.60 615 204191 58538 110325955
Sedation complication 507.49 9.60 364 204442 19491 110365002
Coma 501.78 9.60 833 203973 117036 110267457
Creatinine renal clearance decreased 472.45 9.60 362 204444 21453 110363040
Depressed level of consciousness 425.95 9.60 754 204052 111524 110272969
Drug abuse 395.65 9.60 957 203849 176454 110208039
Orthostatic hypotension 387.81 9.60 543 204263 65706 110318787
Electrocardiogram QRS complex prolonged 380.12 9.60 259 204547 12762 110371731
Balance disorder 379.61 9.60 733 204073 115827 110268666
Blood calcium decreased 360.15 9.60 386 204420 35459 110349034
Pemphigus 347.28 9.60 11 204795 214559 110169934
Disturbance in attention 326.08 9.60 483 204323 61512 110322981
Migraine 299.67 9.60 845 203961 170807 110213686
Anti-cyclic citrullinated peptide antibody positive 299.36 9.60 8 204798 181976 110202517
Hyperhidrosis 299.06 9.60 893 203913 186405 110198088
Overdose 286.12 9.60 1018 203788 232776 110151717
Systemic lupus erythematosus 275.72 9.60 66 204740 254272 110130221
Cardiospasm 275.20 9.60 149 204657 4818 110379675
Nightmare 266.29 9.60 344 204462 38519 110345974
Tension headache 265.87 9.60 185 204621 9433 110375060
Palmoplantar keratoderma 258.48 9.60 147 204659 5240 110379253
Poisoning deliberate 254.79 9.60 278 204528 26053 110358440
Pruritus genital 252.69 9.60 155 204651 6367 110378126
Muscle twitching 248.73 9.60 292 204514 29643 110354850
Duodenal ulcer perforation 242.48 9.60 24 204782 177676 110206817
Wound 238.58 9.60 69 204737 234368 110150125
Sleep terror 235.66 9.60 149 204657 6461 110378032
Hand deformity 234.29 9.60 58 204748 218448 110166045
Glossodynia 232.15 9.60 62 204744 221942 110162551
Intentional overdose 221.22 9.60 642 204164 131859 110252634
Synovitis 209.20 9.60 124 204682 273968 110110525
Facial pain 209.12 9.60 195 204611 15144 110369349
Muscle injury 208.94 9.60 13 204793 140794 110243699
Arthropathy 208.52 9.60 138 204668 287384 110097109
Atrial tachycardia 204.65 9.60 155 204651 9023 110375470
Hallucination 199.63 9.60 522 204284 100910 110283583
Immunisation 197.57 9.60 103 204703 3080 110381413
Carotid artery occlusion 194.64 9.60 153 204653 9412 110375081
Lip swelling 191.71 9.60 340 204466 50327 110334166
Tinnitus 190.05 9.60 375 204431 60165 110324328
Folliculitis 188.69 9.60 40 204766 167613 110216880
Rheumatic fever 185.90 9.60 10 204796 122569 110261924
Rheumatoid factor positive 184.34 9.60 16 204790 131624 110252869
Tachycardia 180.71 9.60 865 203941 225780 110158713
Constipation 180.19 9.60 1207 203599 356579 110027914
Somnolence 178.79 9.60 1050 203756 296399 110088094
Anosmia 174.75 9.60 161 204645 12311 110372182
Sleep disorder due to general medical condition, insomnia type 168.83 9.60 6 204800 105637 110278856
C-reactive protein abnormal 168.13 9.60 21 204785 129674 110254819
Fall 163.87 9.60 1773 203033 601709 109782784
Helicobacter infection 161.81 9.60 67 204739 181810 110202683
Mydriasis 159.47 9.60 201 204605 21956 110362537
Drug ineffective for unapproved indication 153.44 9.60 479 204327 102359 110282134
Electrocardiogram QT prolonged 152.98 9.60 497 204309 108463 110276030
Anticholinergic syndrome 151.38 9.60 96 204710 4184 110380309
Myelosuppression 148.55 9.60 6 204800 94334 110290159
Irritable bowel syndrome 148.51 9.60 59 204747 164156 110220337
Platelet count decreased 146.06 9.60 127 204679 230316 110154177
Ventricular tachycardia 142.98 9.60 298 204508 49711 110334782
Feeling abnormal 142.78 9.60 688 204118 180023 110204470
Hepatic enzyme increased 141.57 9.60 235 204571 320657 110063836
Pain of skin 141.46 9.60 180 204626 19849 110364644
Lip dry 137.88 9.60 13 204793 100070 110284423
Impaired healing 133.91 9.60 101 204705 196616 110187877
Peripheral venous disease 133.64 9.60 5 204801 84112 110300381
Febrile neutropenia 130.64 9.60 242 204564 316525 110067968
Swollen joint count increased 129.48 9.60 6 204800 83655 110300838
Liver injury 125.03 9.60 61 204745 150352 110234141
Breast cancer stage III 124.68 9.60 5 204801 79112 110305381
Suicidal ideation 122.54 9.60 418 204388 93519 110290974
Anxiety 121.52 9.60 1071 203735 344007 110040486
Type 2 diabetes mellitus 120.62 9.60 91 204715 177141 110207352
Anaemia 119.29 9.60 564 204242 546522 109837971
General physical health deterioration 119.02 9.60 397 204409 424898 109959595
Maternal exposure during pregnancy 118.70 9.60 180 204626 254703 110129790
Withdrawal syndrome 116.67 9.60 209 204597 31171 110353322
Drug interaction 114.83 9.60 1423 203383 498760 109885733
Vasculitis 113.54 9.60 223 204583 35650 110348843
Infusion related reaction 112.79 9.60 347 204459 380815 110003678
Neutropenia 110.88 9.60 341 204465 374279 110010214
Diplopia 109.80 9.60 241 204565 41653 110342840
Facet joint syndrome 109.15 9.60 23 204783 96805 110287688
Medication overuse headache 106.91 9.60 54 204752 1509 110382984
Palpitations 106.78 9.60 579 204227 158633 110225860
Disease progression 104.58 9.60 182 204624 243852 110140641
Impaired work ability 102.14 9.60 179 204627 26240 110358253
Swelling face 101.05 9.60 388 204418 91933 110292560
Blindness 99.68 9.60 213 204593 36146 110348347
Nephrolithiasis 99.30 9.60 309 204497 65903 110318590
Suicide attempt 99.16 9.60 417 204389 102977 110281516
Tenosynovitis stenosans 98.87 9.60 69 204737 3534 110380959
Feeling jittery 98.79 9.60 129 204677 14593 110369900
Coombs positive haemolytic anaemia 97.79 9.60 51 204755 1526 110382967
Rubber sensitivity 97.61 9.60 59 204747 2359 110382134
Heart rate increased 97.07 9.60 524 204282 143310 110241183
Gastric pH decreased 96.00 9.60 44 204762 986 110383507
Poor quality sleep 95.56 9.60 180 204626 27897 110356596
Swelling 94.58 9.60 333 204473 350708 110033785
Synovial fluid analysis 94.49 9.60 60 204746 2621 110381872
Oedema 94.22 9.60 152 204654 209824 110174669
Visual impairment 92.25 9.60 492 204314 133936 110250557
Agitation 91.86 9.60 434 204372 112617 110271876
Ill-defined disorder 91.66 9.60 93 204713 156760 110227733
Myoclonus 91.26 9.60 194 204612 32804 110351689
Swollen tongue 90.80 9.60 282 204524 60080 110324413
Dizziness 90.11 9.60 1803 203003 696390 109688103
Psoriatic arthropathy 88.69 9.60 142 204664 196619 110187874
Eye pruritus 86.41 9.60 189 204617 32586 110351907
Hallucination, visual 86.41 9.60 212 204594 39393 110345100
Deep vein thrombosis postoperative 86.39 9.60 6 204800 59285 110325208
Thrombocytopenia 86.14 9.60 343 204463 348542 110035951
Subarachnoid haemorrhage 83.74 9.60 176 204630 29526 110354967
Live birth 83.66 9.60 14 204792 69470 110315023
Wound infection 83.44 9.60 37 204769 96428 110288065
Discomfort 83.30 9.60 170 204636 214537 110169956
Exposure during pregnancy 83.10 9.60 113 204693 167311 110217182
Urinary retention 82.20 9.60 300 204506 69383 110315110
Depressed mood 81.42 9.60 273 204533 60536 110323957
Cytomegalovirus infection 80.83 9.60 5 204801 54439 110330054
Hypersensitivity 80.83 9.60 429 204377 403569 109980924
Blister 80.81 9.60 189 204617 227187 110157306
Grip strength decreased 80.78 9.60 24 204782 80150 110304343
Derealisation 80.33 9.60 50 204756 2108 110382385
Tremor 80.32 9.60 645 204161 201587 110182906
Stomatitis 79.92 9.60 246 204560 269996 110114497
Hypercholesterolaemia 79.91 9.60 34 204772 90803 110293690
Restless legs syndrome 79.04 9.60 154 204652 24472 110360021
Injury 78.89 9.60 129 204677 177136 110207357
Scleritis 77.95 9.60 71 204735 5349 110379144
Hallucinations, mixed 77.59 9.60 88 204718 8605 110375888
Obesity 74.83 9.60 60 204746 113291 110271202
Hypotension 74.40 9.60 1373 203433 522476 109862017
Feeling of despair 73.52 9.60 59 204747 3739 110380754
Pericarditis 72.49 9.60 189 204617 218925 110165568
Lower limb fracture 71.59 9.60 25 204781 75323 110309170
Pulmonary fibrosis 71.22 9.60 51 204755 101991 110282502
Blood cholesterol increased 71.09 9.60 147 204659 184638 110199855
Blepharospasm 70.79 9.60 9 204797 54842 110329651
Cardio-respiratory arrest 69.54 9.60 409 204397 115427 110269066
Autoimmune disorder 68.96 9.60 18 204788 65465 110319028
Lip pruritus 68.66 9.60 38 204768 1284 110383209
Hyperthermia 68.24 9.60 133 204673 21139 110363354
Angioedema 67.91 9.60 361 204445 98139 110286354
Depersonalisation/derealisation disorder 67.52 9.60 45 204761 2136 110382357
Neovascularisation 66.57 9.60 41 204765 1696 110382797
Flank pain 66.30 9.60 138 204668 22992 110361501
Photophobia 66.12 9.60 147 204659 25624 110358869
Aspartate aminotransferase increased 66.06 9.60 122 204684 159814 110224679
Eye pain 65.38 9.60 223 204583 49876 110334617
Loss of consciousness 65.30 9.60 602 204204 195704 110188789
Intentional product misuse 64.17 9.60 444 204362 132460 110252033
Body tinea 63.95 9.60 43 204763 2072 110382421
Joint range of motion decreased 63.77 9.60 79 204727 121753 110262740
Crepitations 63.65 9.60 89 204717 10746 110373747
Respiratory depression 63.24 9.60 165 204641 31836 110352657
H1N1 influenza 62.97 9.60 49 204757 2969 110381524
Onychomadesis 62.71 9.60 6 204800 45657 110338836
Dislocation of vertebra 62.06 9.60 5 204801 43716 110340777
Neutrophil count decreased 61.67 9.60 80 204726 120861 110263632
Multiple drug therapy 61.36 9.60 75 204731 7939 110376554
Malignant neoplasm progression 61.31 9.60 146 204660 174421 110210072
Insomnia 61.26 9.60 973 203833 359617 110024876
Night sweats 61.03 9.60 96 204710 133887 110250606
Migraine with aura 60.79 9.60 51 204755 3441 110381052
Condition aggravated 60.46 9.60 977 203829 733859 109650634
Drug withdrawal syndrome 60.23 9.60 181 204625 37873 110346620
Contraindicated product administered 60.04 9.60 246 204560 248021 110136472
Oedema peripheral 59.76 9.60 360 204446 328300 110056193
Back pain 59.65 9.60 992 203814 370004 110014489
Adjustment disorder with depressed mood 59.65 9.60 6 204800 43877 110340616
Transient ischaemic attack 58.98 9.60 255 204551 63727 110320766
Cogwheel rigidity 58.25 9.60 51 204755 3647 110380846
Gait inability 58.14 9.60 102 204704 136274 110248219
Sepsis 57.72 9.60 362 204444 326984 110057509
Feeling of body temperature change 57.55 9.60 64 204742 6124 110378369
Headache 56.68 9.60 2081 202725 880296 109504197
Emotional disorder 55.49 9.60 104 204702 16056 110368437
Taste disorder 55.12 9.60 26 204780 65361 110319132
Infection 54.77 9.60 419 204387 361781 110022712
Alopecia 53.73 9.60 425 204381 364328 110020165
Multiple organ dysfunction syndrome 53.18 9.60 127 204679 151583 110232910
Pain 53.08 9.60 2217 202589 952738 109431755
Dystonia 50.94 9.60 133 204673 25672 110358821
Abdominal discomfort 50.83 9.60 475 204331 393383 109991110
Head discomfort 50.58 9.60 110 204696 18890 110365603
Vision blurred 50.39 9.60 410 204396 128612 110255881
Cushingoid 50.08 9.60 83 204723 11629 110372864
Liver disorder 49.91 9.60 119 204687 142124 110242369
Lymphadenitis 49.69 9.60 56 204750 5437 110379056
White blood cell count decreased 49.59 9.60 237 204569 229153 110155340
Neuralgia 49.20 9.60 199 204607 48279 110336214
Gastrointestinal disorder 48.86 9.60 256 204550 241696 110142797
Red blood cell sedimentation rate increased 48.56 9.60 44 204762 78258 110306235
Allodynia 48.27 9.60 36 204770 2047 110382446
Rash papular 48.10 9.60 136 204670 27503 110356990
Pneumonia 47.60 9.60 1248 203558 875466 109509027
Bone density decreased 47.50 9.60 97 204709 15945 110368548
Renal function test abnormal 47.45 9.60 70 204736 8876 110375617
Allergy to chemicals 46.73 9.60 43 204763 3282 110381211
Amnesia 46.16 9.60 344 204462 105064 110279429
Hyperaesthesia 45.93 9.60 91 204715 14636 110369857
Muscle disorder 45.60 9.60 59 204747 6613 110377880
Creatinine renal clearance increased 45.44 9.60 44 204762 3581 110380912
Menstrual disorder 45.39 9.60 50 204756 4734 110379759
Oesophageal spasm 45.02 9.60 44 204762 3622 110380871
Product quality issue 44.95 9.60 46 204760 77253 110307240
Synovial cyst 44.91 9.60 78 204728 11352 110373141
Pleuritic pain 44.75 9.60 95 204711 16045 110368448
Sopor 44.50 9.60 159 204647 36387 110348106
Hip arthroplasty 44.33 9.60 24 204782 55789 110328704
Mental disorder 44.06 9.60 165 204641 38626 110345867
Septic shock 44.03 9.60 147 204659 157381 110227112
Inhibitory drug interaction 44.02 9.60 50 204756 4897 110379596
Heart sounds 43.86 9.60 27 204779 1116 110383377
Urticaria 43.55 9.60 379 204427 318478 110066015
Infection susceptibility increased 43.53 9.60 47 204759 4351 110380142
Pregnancy 43.51 9.60 20 204786 51047 110333446
Speech disorder 43.36 9.60 227 204579 61342 110323151
Malaise 43.21 9.60 1585 203221 670234 109714259
Blood creatinine increased 43.10 9.60 183 204623 182706 110201787
Brain injury 42.91 9.60 84 204722 13392 110371101
Somatic symptom disorder 42.75 9.60 40 204766 3119 110381374
Mood swings 42.42 9.60 115 204691 22697 110361796
Pituitary tumour benign 42.33 9.60 38 204768 2809 110381684
Sacroiliitis 42.08 9.60 49 204757 4929 110379564
Drug dependence 42.06 9.60 194 204612 49826 110334667
Tenosynovitis 41.91 9.60 93 204713 16190 110368303
Nail disorder 41.69 9.60 28 204778 57907 110326586
C-reactive protein 41.61 9.60 4 204802 30327 110354166
Alanine aminotransferase increased 41.41 9.60 187 204619 183586 110200907
Renal failure 41.26 9.60 248 204558 226326 110158167
CFTR gene mutation 41.21 9.60 16 204790 233 110384260
Dysarthria 41.17 9.60 282 204524 83839 110300654
Adverse event 40.63 9.60 88 204718 108721 110275772
Therapeutic product effect decreased 40.61 9.60 275 204531 244041 110140452
Incontinence 40.57 9.60 93 204713 16542 110367951
Hospitalisation 40.49 9.60 132 204674 142361 110242132
Rash 40.08 9.60 1186 203620 819778 109564715
Cytokine release syndrome 39.58 9.60 43 204763 70263 110314230
Oesophageal pain 39.30 9.60 48 204758 5077 110379416
Frequent bowel movements 38.73 9.60 45 204761 71345 110313148
Knee arthroplasty 38.51 9.60 38 204768 64910 110319583
Lupus vulgaris 38.28 9.60 8 204798 33875 110350618
Coeliac disease 38.24 9.60 16 204790 43171 110341322
Multiple sclerosis relapse 38.01 9.60 189 204617 50051 110334442
Bradypnoea 37.94 9.60 62 204744 8587 110375906
X-ray abnormal 37.34 9.60 12 204794 38105 110346388
Therapeutic product ineffective 37.23 9.60 34 204772 2570 110381923
Dissociation 37.16 9.60 66 204740 9776 110374717
Respiratory arrest 37.04 9.60 209 204597 58090 110326403
Product used for unknown indication 36.95 9.60 30 204776 1933 110382560
Sciatica 36.81 9.60 72 204734 92327 110292166
Drooling 36.63 9.60 55 204751 7084 110377409
Inflammation 36.52 9.60 209 204597 193029 110191464
Substance abuse 36.47 9.60 75 204731 12388 110372105
Pleural effusion 36.45 9.60 187 204619 177522 110206971
Dyskinesia 36.45 9.60 190 204616 51256 110333237
Prolonged expiration 36.36 9.60 27 204779 1525 110382968
Onychomycosis 36.23 9.60 13 204793 38518 110345975
Sinus tachycardia 35.54 9.60 170 204636 44323 110340170
Atrial fibrillation 35.47 9.60 264 204542 229378 110155115
Antinuclear antibody positive 35.29 9.60 62 204744 9106 110375387
Blood bilirubin increased 35.00 9.60 54 204752 75918 110308575
Psychotic disorder due to a general medical condition 34.71 9.60 15 204791 291 110384202
Corneal reflex decreased 34.62 9.60 18 204788 535 110383958
Cestode infection 34.61 9.60 15 204791 293 110384200
Sinusitis 34.43 9.60 367 204439 296321 110088172
Cardiac failure congestive 34.41 9.60 153 204653 150847 110233646
Prescribed underdose 34.38 9.60 42 204764 65132 110319361
Transplant rejection 34.34 9.60 3 204803 24564 110359929
Crystal nephropathy 34.17 9.60 28 204778 1828 110382665
Cervix neoplasm 34.08 9.60 13 204793 180 110384313
Memory impairment 34 9.60 533 204273 196411 110188082
Retinitis 33.82 9.60 9 204797 32318 110352175
Accidental death 33.78 9.60 44 204762 4965 110379528
Autonomic dysreflexia 33.43 9.60 17 204789 482 110384011
Fat embolism syndrome 33.39 9.60 12 204794 139 110384354
Injection site reaction 33.29 9.60 72 204734 88998 110295495
Bezoar 32.77 9.60 39 204767 4015 110380478
Tenderness 32.43 9.60 124 204682 29313 110355180
Confusional state 32.37 9.60 1115 203691 467565 109916928
Clear cell renal cell carcinoma 31.85 9.60 32 204774 2724 110381769
Tension 31.77 9.60 43 204763 5035 110379458
Decreased appetite 31.73 9.60 656 204150 475190 109909303
Akathisia 31.55 9.60 86 204720 17027 110367466
Conjunctivitis 31.38 9.60 135 204671 33657 110350836
Persistent genital arousal disorder 31.24 9.60 18 204788 658 110383835
Aspergillus infection 31.19 9.60 5 204801 25611 110358882
Soft tissue injury 31.15 9.60 29 204777 2247 110382246
Disorientation 31.15 9.60 231 204575 70440 110314053
Hepatic function abnormal 31.09 9.60 75 204731 89220 110295273
Circulatory collapse 30.61 9.60 159 204647 42834 110341659
Hostility 30.60 9.60 31 204775 2665 110381828
Paralysis 30.38 9.60 80 204726 15520 110368973
Back injury 30.16 9.60 26 204780 47373 110337120
Bone erosion 30.04 9.60 25 204781 46346 110338147
Quality of life decreased 30.01 9.60 75 204731 14094 110370399
Joint swelling 29.97 9.60 609 204197 442236 109942257
Haemoglobin decreased 29.94 9.60 305 204501 248422 110136071
Joint effusion 29.90 9.60 96 204710 20809 110363684
Cardiac failure 29.79 9.60 214 204592 187412 110197081
Wrist deformity 29.69 9.60 33 204773 3156 110381337
Vertigo 29.68 9.60 268 204538 86602 110297891
Mood altered 29.53 9.60 97 204709 21278 110363215
Small fibre neuropathy 29.39 9.60 20 204786 983 110383510
Brugada syndrome 29.33 9.60 24 204782 1564 110382929
Cyanosis 29.32 9.60 121 204685 29620 110354873
Sensory loss 29.31 9.60 97 204709 21360 110363133
Pneumocystis jirovecii pneumonia 28.99 9.60 22 204784 42713 110341780
Pyrexia 28.97 9.60 1364 203442 896901 109487592
Death 28.75 9.60 1032 203774 697837 109686656
Breath sounds abnormal 28.70 9.60 6 204800 25398 110359095
Asthenia 28.66 9.60 1016 203790 687983 109696510
Impaired reasoning 28.54 9.60 10 204796 107 110384386
Hyperlactacidaemia 28.04 9.60 53 204753 8233 110376260
Pancytopenia 27.79 9.60 251 204555 209362 110175131
Ascites 27.75 9.60 84 204722 92724 110291769
Shock haemorrhagic 27.73 9.60 8 204798 27239 110357254
Lupus-like syndrome 27.67 9.60 21 204785 40771 110343722
Premenstrual syndrome 27.64 9.60 16 204790 590 110383903
Accidental overdose 27.31 9.60 177 204629 51657 110332836
Multiple sclerosis 27.29 9.60 107 204699 25591 110358902
Normal newborn 27.29 9.60 4 204802 21892 110362601
Seizure 27.03 9.60 567 204239 220618 110163875
Pulmonary alveolar haemorrhage 26.76 9.60 3 204803 20147 110364346
Pulmonary eosinophilia 26.68 9.60 17 204789 747 110383746
Finger deformity 26.62 9.60 14 204792 33078 110351415
Premature labour 26.61 9.60 55 204751 9117 110375376
Renal impairment 26.61 9.60 222 204584 188223 110196270
Lymphoedema 26.51 9.60 74 204732 14855 110369638
Drug tolerance decreased 26.40 9.60 9 204797 27531 110356962
Delusion of replacement 26.38 9.60 12 204794 264 110384229
Lung disorder 26.38 9.60 210 204596 179837 110204656
Haematuria 26.38 9.60 73 204733 82932 110301561
Anaphylactic shock 26.37 9.60 34 204772 51512 110332981
Cardiac arrest 26.24 9.60 511 204295 196242 110188251
Adverse reaction 26.15 9.60 11 204795 29583 110354910
Exostosis 25.99 9.60 28 204778 45928 110338565
Drug-induced liver injury 25.97 9.60 124 204682 119943 110264550
Vascular malformation 25.70 9.60 17 204789 797 110383696
Diaphragmatic rupture 25.52 9.60 11 204795 212 110384281
Leukopenia 25.46 9.60 166 204640 148625 110235868
Concussion 25.42 9.60 62 204744 11476 110373017
Sternal fracture 25.33 9.60 31 204775 3285 110381208
Respiration abnormal 25.22 9.60 56 204750 9753 110374740
Glucose tolerance impaired 25.11 9.60 56 204750 9781 110374712
Areflexia 25.05 9.60 45 204761 6724 110377769
Bronchopulmonary aspergillosis 24.97 9.60 12 204794 29851 110354642
Libido increased 24.90 9.60 27 204779 2512 110381981
Dental restoration failure 24.76 9.60 19 204787 1128 110383365
Prostate cancer 24.74 9.60 20 204786 37621 110346872
Therapy non-responder 24.69 9.60 180 204626 157127 110227366
Neck pain 24.69 9.60 342 204464 122788 110261705
Carbon dioxide abnormal 24.67 9.60 15 204791 606 110383887
Disseminated intravascular coagulation 24.66 9.60 24 204782 41262 110343231
Blood uric acid increased 24.49 9.60 5 204801 21524 110362969
Post-traumatic neck syndrome 24.41 9.60 27 204779 2568 110381925
Diet failure 24.25 9.60 7 204799 37 110384456
Hypoaesthesia oral 24.25 9.60 78 204728 16924 110367569
Drug resistance 24.17 9.60 42 204764 56332 110328161
Anti-cyclic citrullinated peptide antibody 24.08 9.60 4 204802 19960 110364533
Paranasal cyst 24.08 9.60 17 204789 887 110383606
Osteoarthritis 24.07 9.60 219 204587 182404 110202089
White blood cell count increased 24.00 9.60 95 204711 96747 110287746
Myalgia 23.98 9.60 560 204246 221821 110162672
C-reactive protein increased 23.90 9.60 273 204533 217646 110166847
Lower respiratory tract infection 23.85 9.60 312 204494 242794 110141699
Suspected suicide 23.78 9.60 72 204734 15127 110369366
Restlessness 23.72 9.60 182 204624 56077 110328416
High grade B-cell lymphoma Burkitt-like lymphoma recurrent 23.40 9.60 8 204798 79 110384414
Nail injury 23.32 9.60 16 204790 797 110383696
Sensitivity to weather change 23.29 9.60 55 204751 9973 110374520
Bone marrow failure 23.11 9.60 45 204761 57803 110326690
Parosmia 23.08 9.60 65 204741 13115 110371378
Acute myeloid leukaemia 22.94 9.60 22 204784 38088 110346405
Sleep deficit 22.93 9.60 22 204784 1770 110382723
Cytomegalovirus viraemia 22.72 9.60 3 204803 17761 110366732
Panic attack 22.70 9.60 110 204696 28830 110355663
Eye irritation 22.64 9.60 122 204684 33330 110351163
Blood urea increased 22.61 9.60 42 204764 54915 110329578
Infusion site reaction 22.58 9.60 3 204803 17679 110366814
Hepatitis 22.53 9.60 88 204718 89966 110294527
Prescribed overdose 22.29 9.60 85 204721 87496 110296997
Myelodysplastic syndrome 22.14 9.60 22 204784 37462 110347031
Haemolysis 21.63 9.60 71 204735 15568 110368925
Hypohidrosis 21.53 9.60 11 204795 315 110384178
Haemorrhage 21.46 9.60 113 204693 106579 110277914
Brain stem microhaemorrhage 21.41 9.60 6 204800 28 110384465
Wheezing 21.37 9.60 338 204468 254892 110129601
Respiratory failure 21.25 9.60 276 204530 215056 110169437
Hot flush 21.18 9.60 201 204605 65835 110318658
Psychotic disorder 21.04 9.60 164 204642 50773 110333720
Hyperprolactinaemia 20.96 9.60 41 204765 6534 110377959
Post-traumatic stress disorder 20.86 9.60 41 204765 6555 110377938
Device expulsion 20.83 9.60 16 204790 30875 110353618
Extrapyramidal disorder 20.71 9.60 107 204699 28760 110355733
Electrocardiogram PR prolongation 20.57 9.60 21 204785 1822 110382671
Biliary sepsis 20.57 9.60 21 204785 1822 110382671
Polymenorrhoea 20.52 9.60 17 204789 1127 110383366
HIV peripheral neuropathy 20.44 9.60 6 204800 34 110384459
Burning sensation 20.41 9.60 207 204599 69005 110315488
CYP3A4 polymorphism 20.40 9.60 7 204799 70 110384423
Activated partial thromboplastin time prolonged 20.27 9.60 8 204798 22360 110362133
Epilepsy 20.23 9.60 106 204700 100103 110284390
Postural orthostatic tachycardia syndrome 20.20 9.60 21 204785 1861 110382632
Coma scale abnormal 20.10 9.60 51 204755 9675 110374818
Renal mass 20.09 9.60 29 204777 3606 110380887
No adverse event 19.88 9.60 70 204736 73769 110310724
Slow speech 19.78 9.60 28 204778 3420 110381073
Cerebellar stroke 19.74 9.60 15 204791 877 110383616
Subclavian artery embolism 19.56 9.60 5 204801 15 110384478
Limb injury 19.51 9.60 128 204678 37508 110346985
Cerebellar microhaemorrhage 19.49 9.60 6 204800 41 110384452
CADASIL 19.49 9.60 6 204800 41 110384452
Eyelid myoclonus 19.48 9.60 8 204798 136 110384357
Muscle rigidity 19.32 9.60 92 204714 23939 110360554
Hyperbilirubinaemia 19.30 9.60 17 204789 30654 110353839
Mania 19.25 9.60 83 204723 20713 110363780
Eosinophilia 19.13 9.60 50 204756 57886 110326607
Panniculitis 19.07 9.60 3 204803 15579 110368914
Pneumonia aspiration 18.95 9.60 232 204574 81001 110303492
Eyelid exfoliation 18.94 9.60 10 204796 307 110384186
Femoral artery dissection 18.89 9.60 6 204800 46 110384447
Bladder cancer 18.82 9.60 7 204799 20285 110364208
Numb chin syndrome 18.78 9.60 6 204800 47 110384446
Drug hypersensitivity 18.76 9.60 670 204136 453420 109931073
Bradyphrenia 18.76 9.60 56 204750 11672 110372821
Laboratory test abnormal 18.75 9.60 33 204773 44046 110340447
Bronchiectasis 18.74 9.60 24 204782 36469 110348024
Laryngitis 18.73 9.60 31 204775 42380 110342113
Hypertonia 18.34 9.60 45 204761 8361 110376132
Depressive symptom 18.31 9.60 45 204761 8369 110376124
Pulmonary embolism 18.30 9.60 283 204523 214191 110170302
Miosis 18.29 9.60 85 204721 21898 110362595
Liver function test increased 18.25 9.60 93 204713 88455 110296038
Lichen sclerosus 18.18 9.60 16 204790 1152 110383341
Muscular weakness 18.12 9.60 595 204211 247873 110136620
Synovial disorder 18.11 9.60 25 204781 2982 110381511
Palmar-plantar erythrodysaesthesia syndrome 18.11 9.60 30 204776 40995 110343498
Pancreatitis relapsing 18.09 9.60 18 204788 1514 110382979
Agoraphobia 18.00 9.60 13 204793 703 110383790
Dry eye 17.98 9.60 170 204636 55623 110328870
Visual snow syndrome 17.95 9.60 6 204800 55 110384438
Nasopharyngitis 17.89 9.60 575 204231 393786 109990707
Alcoholic ketoacidosis 17.85 9.60 6 204800 56 110384437
Poliomyelitis 17.85 9.60 6 204800 56 110384437
Foetal growth restriction 17.84 9.60 25 204781 3025 110381468
Vestibular migraine 17.80 9.60 8 204798 171 110384322
Labelled drug-drug interaction issue 17.45 9.60 29 204777 4072 110380421
Vulvovaginal swelling 17.43 9.60 12 204794 601 110383892
Metastases to liver 17.43 9.60 24 204782 35362 110349131
Maternal condition affecting foetus 17.26 9.60 8 204798 184 110384309
Patient dissatisfaction with treatment 17.22 9.60 10 204796 371 110384122
Hepatocellular injury 17.17 9.60 156 204650 50486 110334007
Vaccination site bruising 17.14 9.60 4 204802 7 110384486
Cellulitis 17.04 9.60 328 204478 125688 110258805
Haemophagocytic lymphohistiocytosis 17.00 9.60 20 204786 31539 110352954
Salmonella bacteraemia 17.00 9.60 12 204794 626 110383867
Rectal haemorrhage 16.99 9.60 141 204665 119692 110264801
Magnesium deficiency 16.93 9.60 13 204793 772 110383721
Gout 16.83 9.60 26 204780 36540 110347953
Heart rate 16.82 9.60 9 204797 284 110384209
Vaccination site oedema 16.79 9.60 4 204802 8 110384485
Tubulointerstitial nephritis and uveitis syndrome 16.63 9.60 10 204796 396 110384097
Sleep apnoea syndrome 16.58 9.60 130 204676 40317 110344176
Bacterial infection 16.56 9.60 38 204768 45998 110338495
Female genital tract fistula 16.54 9.60 5 204801 16514 110367979
Product use in unapproved indication 16.52 9.60 999 203807 446378 109938115
Therapy interrupted 16.44 9.60 43 204763 49779 110334714
Gastrointestinal haemorrhage 16.38 9.60 212 204594 165306 110219187
Arrhythmia 16.36 9.60 199 204607 69376 110315117
Hyperphosphataemia 16.32 9.60 5 204801 16376 110368117
Pharyngeal oedema 16.32 9.60 67 204739 16361 110368132
Adiposis dolorosa 16.24 9.60 9 204797 305 110384188
Anaemia of malignant disease 16.22 9.60 14 204792 982 110383511
Hepatic enzyme decreased 16.15 9.60 14 204792 988 110383505
Irritability 16.07 9.60 147 204659 47662 110336831
Nerve injury 16.06 9.60 50 204756 10663 110373830
Application site pain 15.98 9.60 33 204773 5466 110379027
Iron binding capacity total decreased 15.89 9.60 11 204795 556 110383937
Child maltreatment syndrome 15.88 9.60 3 204803 0 110384493
Infrapatellar fat pad inflammation 15.86 9.60 8 204798 223 110384270
Allergic sinusitis 15.84 9.60 18 204788 1763 110382730
Paradoxical drug reaction 15.82 9.60 47 204759 9770 110374723
Foetal death 15.81 9.60 5 204801 16040 110368453
Antisocial behaviour 15.78 9.60 13 204793 855 110383638
Acute psychosis 15.78 9.60 31 204775 4956 110379537
Drug eruption 15.73 9.60 49 204757 53610 110330883
Pseudomonas infection 15.72 9.60 17 204789 27836 110356657
Immunodeficiency 15.70 9.60 30 204776 38808 110345685
Genital infection female 15.67 9.60 6 204800 84 110384409
Lethargy 15.67 9.60 252 204554 93324 110291169
Mouth swelling 15.65 9.60 39 204767 7315 110377178
Pericardial effusion 15.57 9.60 54 204752 57163 110327330
Aggression 15.55 9.60 173 204633 59037 110325456
Femoral nerve palsy 15.54 9.60 6 204800 86 110384407
Aptyalism 15.52 9.60 13 204793 875 110383618
Anterograde amnesia 15.52 9.60 13 204793 875 110383618
Deep vein thrombosis 15.43 9.60 175 204631 139712 110244781
Unevaluable event 15.38 9.60 57 204749 59170 110325323
Mucosal dryness 15.34 9.60 28 204778 4235 110380258
Substance use 15.34 9.60 21 204785 2485 110382008
Drug dispensed to wrong patient 15.28 9.60 12 204794 737 110383756
Cytopenia 15.27 9.60 20 204786 30096 110354397
Multiple-drug resistance 15.21 9.60 3 204803 13232 110371261
Full blood count abnormal 15.18 9.60 53 204753 55999 110328494
Metastases to central nervous system 15.15 9.60 12 204794 22805 110361688
Dysphemia 15.15 9.60 27 204779 4010 110380483
Antidepressant drug level increased 15.07 9.60 11 204795 605 110383888
Cystitis interstitial 15.02 9.60 16 204790 1458 110383035
Appetite disorder 15.02 9.60 46 204760 9723 110374770
Haemodialysis 15.00 9.60 7 204799 17712 110366781
Generalised tonic-clonic seizure 14.92 9.60 161 204645 54519 110329974
Normochromic normocytic anaemia 14.92 9.60 3 204803 13054 110371439
Macular degeneration 14.88 9.60 11 204795 21648 110362845
Ulcer haemorrhage 14.83 9.60 12 204794 22559 110361934
Acquired diaphragmatic eventration 14.82 9.60 12 204794 770 110383723
Plasma cell myeloma 14.80 9.60 63 204743 62873 110321620
Food refusal 14.76 9.60 13 204793 937 110383556
SLE arthritis 14.74 9.60 11 204795 626 110383867
Cerebral infarction 14.74 9.60 48 204758 51790 110332703
Pulmonary haemorrhage 14.73 9.60 6 204800 16450 110368043
Mastoiditis 14.68 9.60 21 204785 2590 110381903
Acute graft versus host disease 14.64 9.60 3 204803 12878 110371615
Secondary adrenocortical insufficiency 14.56 9.60 28 204778 4406 110380087
Walking aid user 14.49 9.60 15 204791 25060 110359433
Sinus pain 14.48 9.60 33 204773 5846 110378647
Poor peripheral circulation 14.40 9.60 27 204779 4170 110380323
Acute lung injury 14.38 9.60 23 204783 3128 110381365
Pharyngeal swelling 14.35 9.60 52 204754 11980 110372513
Impaired quality of life 14.31 9.60 100 204706 29917 110354576
Respiratory acidosis 14.22 9.60 57 204749 13769 110370724
Otitis media 14.21 9.60 38 204768 7438 110377055
Sensory disturbance 14.21 9.60 67 204739 17362 110367131
Dry skin 14.14 9.60 279 204527 107374 110277119
Mitochondrial encephalomyopathy 14.09 9.60 6 204800 112 110384381
Osteoporosis 14.02 9.60 99 204707 87053 110297440
Blood calcium increased 13.98 9.60 8 204798 18032 110366461
Hyperreflexia 13.97 9.60 44 204762 9441 110375052
Rectal cancer metastatic 13.84 9.60 10 204796 541 110383952
Procedural anxiety 13.82 9.60 12 204794 849 110383644
Term birth 13.81 9.60 3 204803 3 110384490
Naevus haemorrhage 13.76 9.60 6 204800 119 110384374
Injection site erythema 13.72 9.60 110 204696 94066 110290427
Poor venous access 13.70 9.60 85 204721 24437 110360056
Abnormal loss of weight 13.68 9.60 46 204760 10211 110374282
Genital herpes 13.61 9.60 20 204786 2527 110381966
Nausea 13.61 9.60 2541 202265 1233149 109151344
Vaccination site pruritus 13.58 9.60 4 204802 23 110384470
Cystitis haemorrhagic 13.55 9.60 3 204803 12206 110372287
Vitamin B12 decreased 13.50 9.60 30 204776 5227 110379266
Hyperuricaemia 13.50 9.60 5 204801 14526 110369967
Myofascial pain syndrome 13.45 9.60 20 204786 2553 110381940
Benzodiazepine drug level therapeutic 13.43 9.60 4 204802 24 110384469
Internal carotid artery deformity 13.35 9.60 3 204803 4 110384489
Thymus disorder 13.29 9.60 10 204796 576 110383917
International normalised ratio increased 13.27 9.60 100 204706 86672 110297821
Respiratory distress 13.27 9.60 74 204732 68800 110315693
Post procedural complication 13.21 9.60 18 204788 26640 110357853
Drug ineffective 13.20 9.60 3091 201715 1517449 108867044
Mast cell degranulation present 13.19 9.60 5 204801 68 110384425
Thoracic radiculopathy 13.16 9.60 4 204802 26 110384467
Blood phosphorus increased 13.02 9.60 7 204799 16333 110368160
Aortic stenosis 12.99 9.60 4 204802 13055 110371438
Chronic idiopathic pain syndrome 12.97 9.60 7 204799 225 110384268
Autism spectrum disorder 12.96 9.60 17 204789 1931 110382562
Myoglobin urine 12.91 9.60 4 204802 28 110384465
Blood creatine phosphokinase 12.90 9.60 8 204798 335 110384158
Oral mucosal blistering 12.80 9.60 38 204768 7896 110376597
Lipids increased 12.79 9.60 17 204789 1956 110382537
Poisoning 12.74 9.60 95 204711 29010 110355483
Paraesthesia 12.67 9.60 630 204176 275891 110108602
Enlarged uvula 12.62 9.60 9 204797 477 110384016
Breast pain 12.60 9.60 44 204762 9956 110374537
Good syndrome 12.60 9.60 3 204803 6 110384487
Haematochezia 12.55 9.60 145 204661 115379 110269114
Illness 12.55 9.60 218 204588 81953 110302540
Respiratory symptom 12.51 9.60 6 204800 14939 110369554
Delusion 12.44 9.60 81 204725 23674 110360819
Ventricular arrhythmia 12.38 9.60 44 204762 10043 110374450
Linear IgA disease 12.36 9.60 26 204780 4363 110380130
Graft versus host disease 12.35 9.60 10 204796 18796 110365697
Hyperammonaemia 12.30 9.60 5 204801 13727 110370766
Skin necrosis 12.28 9.60 13 204793 21499 110362994
Obstructive airways disorder 12.26 9.60 44 204762 46105 110338388
On and off phenomenon 12.22 9.60 26 204780 4398 110380095
Autonomic neuropathy 12.20 9.60 18 204788 2282 110382211
Psychotic symptom 12.19 9.60 24 204782 3843 110380650
Oliguria 12.16 9.60 10 204796 18647 110365846
Pharyngeal mass 12.15 9.60 8 204798 372 110384121
Victim of homicide 12.14 9.60 7 204799 256 110384237
Basal cell carcinoma 12.13 9.60 43 204763 45227 110339266
Urticaria aquagenic 12.13 9.60 4 204802 35 110384458
Nail bed tenderness 12.07 9.60 8 204798 376 110384117
Neurotoxicity 12.05 9.60 39 204767 42168 110342325
Hypoalbuminaemia 12.05 9.60 22 204784 28952 110355541
Metastases to bone 12.02 9.60 25 204781 31347 110353146
Immune thrombocytopenia 11.96 9.60 77 204729 22417 110362076
Pancreatitis 11.96 9.60 113 204693 93420 110291073
Brain natriuretic peptide increased 11.96 9.60 3 204803 11206 110373287
Blood lactate dehydrogenase increased 11.96 9.60 42 204764 44292 110340201
Faecaloma 11.93 9.60 57 204749 14851 110369642
Urinary incontinence 11.87 9.60 140 204666 48447 110336046
Underdose 11.86 9.60 69 204737 63485 110321008
Cardiac murmur 11.83 9.60 17 204789 24611 110359882
Diarrhoea 11.82 9.60 1892 202914 1137613 109246880
Anti-neutrophil cytoplasmic antibody positive vasculitis 11.82 9.60 29 204777 5388 110379105
Phonophobia 11.81 9.60 10 204796 683 110383810
Hepatic cirrhosis 11.79 9.60 75 204731 67551 110316942
Loss of personal independence in daily activities 11.78 9.60 201 204605 149819 110234674
Depression 11.77 9.60 709 204097 316626 110067867
Hypotonia 11.74 9.60 59 204747 15686 110368807
Transaminases increased 11.73 9.60 69 204737 63321 110321172
Product use issue 11.73 9.60 465 204341 311230 110073263
Sinoatrial block 11.69 9.60 14 204792 1451 110383042
Bipolar disorder 11.67 9.60 40 204766 8967 110375526
Peritonitis 11.66 9.60 27 204779 32580 110351913
Adenovirus infection 11.62 9.60 3 204803 10991 110373502
Drug use disorder 11.61 9.60 65 204741 18009 110366484
Hypogammaglobulinaemia 11.61 9.60 12 204794 20064 110364429
Complication associated with device 11.61 9.60 12 204794 20061 110364432
Arterial occlusive disease 11.56 9.60 7 204799 15301 110369192
Vitreous detachment 11.55 9.60 19 204787 2646 110381847
Adrenal insufficiency 11.54 9.60 40 204766 42350 110342143
Bladder disorder 11.53 9.60 46 204760 11091 110373402
Organising pneumonia 11.49 9.60 6 204800 14237 110370256
Decreased interest 11.49 9.60 27 204779 4881 110379612
Hypoventilation 11.46 9.60 37 204769 8044 110376449
Venoocclusive liver disease 11.42 9.60 7 204799 15200 110369293
Hypovolaemia 11.40 9.60 14 204792 21660 110362833
Diaphragmatic paralysis 11.38 9.60 13 204793 1281 110383212
Pulmonary hypertension 11.38 9.60 58 204748 55162 110329331
Trigeminal neuralgia 11.36 9.60 25 204781 4327 110380166
Dry age-related macular degeneration 11.16 9.60 7 204799 299 110384194
Oral herpes 11.16 9.60 109 204697 35971 110348522
Hepatic failure 11.10 9.60 78 204728 68661 110315832
Venous angioma of brain 11.08 9.60 4 204802 47 110384446
Vertebral artery hypoplasia 11.07 9.60 3 204803 12 110384481
Red blood cell sedimentation rate decreased 11.06 9.60 13 204793 1321 110383172
Flat affect 11.05 9.60 18 204788 2487 110382006
Injection site swelling 11.05 9.60 68 204738 61722 110322771
Post herpetic neuralgia 11.03 9.60 21 204785 3280 110381213
Abdominal pain 11.02 9.60 1098 203708 511891 109872602
Disorganised speech 11.02 9.60 21 204785 3282 110381211
Communication disorder 11.02 9.60 27 204779 5012 110379481
Sports injury 10.97 9.60 6 204800 198 110384295
Acne pustular 10.96 9.60 7 204799 309 110384184
Menstruation delayed 10.93 9.60 15 204791 1779 110382714
Behaviour disorder 10.93 9.60 41 204765 9606 110374887
Enterococcal infection 10.87 9.60 13 204793 20353 110364140
Disability 10.83 9.60 25 204781 30198 110354295
Diabetic neuropathy 10.80 9.60 33 204773 6966 110377527
Chemical burns of eye 10.79 9.60 5 204801 115 110384378
Blood test abnormal 10.73 9.60 23 204783 28531 110355962
Dysphonia 10.73 9.60 199 204607 75730 110308763
Hypoglycaemic seizure 10.71 9.60 11 204795 961 110383532
Clonus 10.68 9.60 38 204768 8678 110375815
Personal relationship issue 10.65 9.60 6 204800 210 110384283
Oesophageal carcinoma 10.65 9.60 4 204802 11520 110372973
Onychophagia 10.63 9.60 5 204801 119 110384374
Skin burning sensation 10.58 9.60 73 204733 21752 110362741
Binge eating 10.55 9.60 9 204797 621 110383872
Thrombotic microangiopathy 10.53 9.60 24 204782 29125 110355368
Lenticular opacities 10.49 9.60 9 204797 626 110383867
Haematoma infection 10.49 9.60 14 204792 1618 110382875
Road traffic accident 10.46 9.60 138 204668 107260 110277233
Bronchitis 10.42 9.60 372 204434 156660 110227833
Pupillary reflex impaired 10.41 9.60 23 204783 3992 110380501
Cardiotoxicity 10.38 9.60 60 204746 16821 110367672
Stress 10.36 9.60 262 204544 105086 110279407
Vertebral lateral recess stenosis 10.27 9.60 7 204799 345 110384148
Acquired cystic kidney disease 10.26 9.60 4 204802 59 110384434
Colitis ischaemic 10.21 9.60 62 204744 17688 110366805
Laryngeal dyspnoea 10.20 9.60 7 204799 349 110384144
Clumsiness 10.19 9.60 22 204784 3758 110380735
Clostridium difficile colitis 10.19 9.60 44 204762 43734 110340759
Hyperacusis 10.14 9.60 19 204787 2933 110381560
Respiratory rate decreased 10.12 9.60 30 204776 6228 110378265
Colitis ulcerative 10.09 9.60 93 204713 77270 110307223
Pemphigoid 10.08 9.60 13 204793 19694 110364799
Inappropriate affect 10.05 9.60 14 204792 1685 110382808
Unresponsive to stimuli 10.02 9.60 170 204636 63620 110320873
Heliotrope rash 9.97 9.60 6 204800 238 110384255
Proctitis 9.92 9.60 10 204796 16917 110367576
Oxalosis 9.92 9.60 5 204801 139 110384354
Nervous system disorder 9.90 9.60 96 204710 31625 110352868
Ischaemic stroke 9.89 9.60 41 204765 41222 110343271
Ligamentum flavum hypertrophy 9.87 9.60 7 204799 368 110384125
Red blood cell sedimentation rate abnormal 9.85 9.60 19 204787 24490 110360003
Ear pain 9.82 9.60 58 204748 53168 110331325
Osteoarthropathy 9.80 9.60 7 204799 372 110384121
Tooth abscess 9.80 9.60 64 204742 18725 110365768
Urticaria cholinergic 9.79 9.60 4 204802 67 110384426
Diffuse large B-cell lymphoma 9.78 9.60 9 204797 15889 110368604
Mouth ulceration 9.76 9.60 134 204672 48004 110336489
Deformity 9.75 9.60 41 204765 10119 110374374
Substance-induced psychotic disorder 9.74 9.60 27 204779 5397 110379096
Wrong technique in product usage process 9.74 9.60 109 204697 87239 110297254
Sciatic nerve neuropathy 9.73 9.60 8 204798 525 110383968
Burning feet syndrome 9.72 9.60 6 204800 249 110384244
Hypoxia 9.70 9.60 175 204631 129340 110255153
Mobility decreased 9.68 9.60 535 204271 236887 110147606
Intraocular pressure increased 9.68 9.60 4 204802 10872 110373621
Vasculitic rash 9.66 9.60 16 204790 2241 110382252
Pharyngeal enanthema 9.63 9.60 4 204802 70 110384423
Hypercalcaemia 9.62 9.60 49 204757 46608 110337885
Thoracic outlet syndrome 9.61 9.60 5 204801 149 110384344

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N06AA09 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Non-selective monoamine reuptake inhibitors
ATC N06CA01 NERVOUS SYSTEM
PSYCHOANALEPTICS
PSYCHOLEPTICS AND PSYCHOANALEPTICS IN COMBINATION
Antidepressants in combination with psycholeptics
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35640 adrenergic uptake inhibitor
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:78298 environmental contaminant
CHEBI has role CHEBI:140489 tropomyosin-related kinase B receptor agonist
MeSH PA D000700 Analgesics
MeSH PA D000928 Antidepressive Agents
MeSH PA D000929 Antidepressive Agents, Tricyclic
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018663 Adrenergic Agents
MeSH PA D018689 Sensory System Agents
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D018759 Adrenergic Uptake Inhibitors
MeSH PA D049990 Membrane Transport Modulators
FDA EPC N0000175752 Tricyclic Antidepressant

Related Drugs by ATC class:

N06AA Non-selective monoamine reuptake inhibitors 20 drugs
amineptineamoxapinebutriptylineclomipraminedesipraminedibenzepindimetacrinedosulepindoxepinimipramineimipramine oxideiprindole show all 20 →
N06CA Antidepressants in combination with psycholeptics 2 drugs
fluoxetinemelitracen

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Depressive disorder indication 35489007
Mixed anxiety and depressive disorder indication 231504006
Posttraumatic stress disorder off-label use 47505003 DOID:2055
Bulimia nervosa off-label use 78004001
Fibromyalgia off-label use 203082005 DOID:631
Neuropathic pain off-label use 247398009
Migraine Prevention off-label use
Suicidal thoughts contraindication 6471006
Alcoholism contraindication 7200002
Organophosphate poisoning contraindication 8260003
Weight gain finding contraindication 8943002
Sinus tachycardia contraindication 11092001
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Chronic disease of respiratory system contraindication 17097001
Disorder of lung contraindication 19829001 DOID:850
Myocardial infarction contraindication 22298006 DOID:5844
Glaucoma contraindication 23986001 DOID:1686
Alcohol intoxication contraindication 25702006
Shock contraindication 27942005
Orthostatic hypotension contraindication 28651003
Torsades de pointes contraindication 31722008
Parkinsonism contraindication 32798002
Hyperthyroidism contraindication 34486009 DOID:7998
Hyperactive behavior contraindication 44548000
Conduction disorder of the heart contraindication 44808001
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Paralytic ileus contraindication 55525008 DOID:8442
Substance abuse contraindication 66214007
Psychotic disorder contraindication 69322001
Sleep apnea contraindication 73430006 DOID:0050847
Extrapyramidal disease contraindication 76349003
Hyperglycemia contraindication 80394007 DOID:4195
Chronic idiopathic constipation contraindication 82934008
Open-angle glaucoma contraindication 84494001 DOID:1067
Epilepsy contraindication 84757009 DOID:1826
Leukopenia contraindication 84828003 DOID:615
Stupor contraindication 89458003
Kidney disease contraindication 90708001 DOID:557
Tardive dyskinesia contraindication 102449007
Prolonged QT interval contraindication 111975006
Hypoalbuminemia contraindication 119247004
Acute disease of cardiovascular system contraindication 128487001
Bipolar affective disorder, current episode manic contraindication 191618007
Angina pectoris contraindication 194828000
Disease of liver contraindication 235856003 DOID:409
Metabolic syndrome X contraindication 237602007 DOID:14221
Hyperprolactinemia contraindication 237662005 DOID:12700
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Syncope contraindication 271594007
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Severe chronic obstructive pulmonary disease contraindication 313299006
Coma contraindication 371632003
At risk for aspiration contraindication 371736008
Angle-closure glaucoma contraindication 392291006 DOID:13550
Visual impairment contraindication 397540003
Breastfeeding (mother) contraindication 413712001
Myocardial ischemia contraindication 414795007 DOID:3393
Obesity contraindication 414916001 DOID:9970
Myocardial infarction in recovery phase contraindication 418044006
Porphyria contraindication 418470004
Congenital long QT syndrome contraindication 442917000
Carcinoma of female breast contraindication 447782002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.66 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR Kd 8.37 WOMBAT-PK CHEMBL
Sodium-dependent noradrenaline transporter Transporter INHIBITOR Kd 7.46 WOMBAT-PK CHEMBL
D(2) dopamine receptor GPCR Ki 6.71 WOMBAT-PK
Alpha-2A adrenergic receptor GPCR Ki 6.88 DRUG MATRIX
Sigma non-opioid intracellular receptor 1 Membrane receptor IC50 6.25 WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5 WOMBAT-PK
5-hydroxytryptamine receptor 1A GPCR Ki 6.72 WOMBAT-PK
5-hydroxytryptamine receptor 2A GPCR Ki 7.96 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR Ki 7.40 WOMBAT-PK
5-hydroxytryptamine receptor 2C GPCR Ki 8.10 WOMBAT-PK
5-hydroxytryptamine receptor 6 GPCR Ki 7.05 WOMBAT-PK
5-hydroxytryptamine receptor 7 GPCR Ki 6.40 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR IC50 7.90 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR IC50 8 WOMBAT-PK
D(3) dopamine receptor GPCR Ki 6.69 WOMBAT-PK
D(1B) dopamine receptor GPCR Ki 6.77 WOMBAT-PK
Histamine H1 receptor GPCR ANTAGONIST Ki 9.30 WOMBAT-PK
Histamine H2 receptor GPCR IC50 6.80 WOMBAT-PK
Histamine H4 receptor GPCR Ki 8.14 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR ANTAGONIST Ki 7.83 WOMBAT-PK
Muscarinic acetylcholine receptor M2 GPCR Ki 8.10 WOMBAT-PK
Muscarinic acetylcholine receptor M3 GPCR Ki 7.89 WOMBAT-PK
Muscarinic acetylcholine receptor M4 GPCR Ki 8.14 WOMBAT-PK
Muscarinic acetylcholine receptor M5 GPCR Ki 7.80 WOMBAT-PK
Aldehyde oxidase Enzyme IC50 6.59 WOMBAT-PK
Alpha-2C adrenergic receptor GPCR Ki 8.07 DRUG MATRIX
Sodium channel protein type 2 subunit alpha Ion channel IC50 5.51 CHEMBL
Sodium channel protein type 9 subunit alpha Ion channel IC50 6 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 5.21 CHEMBL
Alpha-1D adrenergic receptor GPCR Ki 8.25 DRUG MATRIX
Proto-oncogene tyrosine-protein kinase receptor Ret Kinase IC50 6 CHEMBL
Poly [ADP-ribose] polymerase 1 Enzyme IC50 5.78 CHEMBL
High affinity nerve growth factor receptor Kinase IC50 4.22 CHEMBL
Voltage-dependent N-type calcium channel subunit alpha-1B Ion channel IC50 4.92 CHEMBL
Solute carrier family 22 member 1 Transporter IC50 4.77 CHEMBL
Solute carrier family 22 member 2 Transporter IC50 4.85 WOMBAT-PK
Sodium channel protein type 5 subunit alpha Ion channel IC50 5.80 CHEMBL
D(1A) dopamine receptor GPCR Ki 7.05 WOMBAT-PK
Alpha-1B adrenergic receptor GPCR Ki 7.38 DRUG MATRIX
5-hydroxytryptamine receptor 1B GPCR Ki 5.77 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR IC50 10.70 CHEMBL
5-hydroxytryptamine receptor 1A GPCR IC50 5.70 CHEMBL
Sodium-dependent serotonin transporter Transporter IC50 5.07 CHEMBL
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 8.40 IUPHAR
Transporter Transporter IC50 5.60 CHEMBL
5-hydroxytryptamine receptor 7 GPCR ANTAGONIST Ki 7 IUPHAR
5-hydroxytryptamine receptor 7 GPCR ANTAGONIST Ki 6.40 IUPHAR
5-hydroxytryptamine receptor 2C GPCR ANTAGONIST Ki 8.10 IUPHAR
Histamine H1 receptor GPCR IC50 10.70 CHEMBL
5-hydroxytryptamine receptor 6 GPCR ANTAGONIST Ki 7.20 IUPHAR
Muscarinic acetylcholine receptor GPCR IC50 6.52 CHEMBL
G protein-activated inward rectifier potassium channel 2 Ion channel BLOCKER IC50 4 IUPHAR

External reference:

IDSource
4019607 VUID
N0000147702 NUI
D00809 KEGG_DRUG
549-18-8 SECONDARY_CAS_RN
203168 RXNORM
C0002600 UMLSCUI
CHEBI:2666 CHEBI
TP0 PDB_CHEM_ID
CHEMBL629 ChEMBL_ID
DB00321 DRUGBANK_ID
CHEMBL1200964 ChEMBL_ID
D000639 MESH_DESCRIPTOR_UI
2160 PUBCHEM_CID
200 IUPHAR_LIGAND_ID
976 INN_ID
1806D8D52K UNII
4178 MMSL
4240 MMSL
d00146 MMSL
4017743 VANDF
4019607 VANDF
001501 NDDF
004600 NDDF
372726002 SNOMEDCT_US
40589005 SNOMEDCT_US
48384000 SNOMEDCT_US
1806D8D52K INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Perphenazine and Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 2 0378-0042 TABLET, FILM COATED 10 mg ORAL ANDA 19 sections
Perphenazine and Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 2 0378-0073 TABLET, FILM COATED 50 mg ORAL ANDA 19 sections
Chlordiazepoxide and Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 2 0378-0211 TABLET, FILM COATED 14 mg ORAL ANDA 24 sections
Chlordiazepoxide and Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 2 0378-0277 TABLET, FILM COATED 27.98 mg ORAL ANDA 24 sections
Perphenazine and Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 2 0378-0330 TABLET, FILM COATED 10 mg ORAL ANDA 19 sections
Perphenazine and Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 2 0378-0442 TABLET, FILM COATED 25 mg ORAL ANDA 19 sections
Perphenazine and Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 2 0378-0574 TABLET, FILM COATED 25 mg ORAL ANDA 19 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0463-6351 TABLET, FILM COATED 25 mg ORAL ANDA 23 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0463-6352 TABLET, FILM COATED 50 mg ORAL ANDA 23 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0463-6354 TABLET, FILM COATED 100 mg ORAL ANDA 23 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-1486 TABLET, FILM COATED 10 mg ORAL ANDA 21 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-1487 TABLET, FILM COATED 25 mg ORAL ANDA 21 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-1488 TABLET, FILM COATED 50 mg ORAL ANDA 21 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-1489 TABLET, FILM COATED 75 mg ORAL ANDA 21 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-1490 TABLET, FILM COATED 100 mg ORAL ANDA 21 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-1491 TABLET, FILM COATED 150 mg ORAL ANDA 21 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-7410 TABLET 25 mg ORAL ANDA 16 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-7411 TABLET 50 mg ORAL ANDA 16 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-109 TABLET, FILM COATED 25 mg ORAL ANDA 22 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-110 TABLET, FILM COATED 50 mg ORAL ANDA 22 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-250 TABLET, FILM COATED 10 mg ORAL ANDA 22 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 11788-077 TABLET 10 mg ORAL ANDA 20 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 11788-078 TABLET 25 mg ORAL ANDA 20 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 11788-079 TABLET 50 mg ORAL ANDA 20 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 11788-080 TABLET 75 mg ORAL ANDA 20 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 11788-081 TABLET 100 mg ORAL ANDA 20 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 11788-082 TABLET 150 mg ORAL ANDA 20 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 16571-105 TABLET 10 mg ORAL ANDA 16 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 16571-106 TABLET 25 mg ORAL ANDA 16 sections
Amitriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 16571-107 TABLET 50 mg ORAL ANDA 16 sections