Stem definition | Drug id | CAS RN |
---|---|---|
prednisone and prednisolone derivatives | 819 | 382-67-2 |
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
Feb. 28, 1977 | FDA | TARO PHARMS NORTH |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Pemphigus | 4352.30 | 54.43 | 3830 | 176733 | 179896 | 63128563 |
Glossodynia | 4108.75 | 54.43 | 3665 | 176898 | 175211 | 63133248 |
Systemic lupus erythematosus | 3932.38 | 54.43 | 3831 | 176732 | 205087 | 63103372 |
Hand deformity | 3570.49 | 54.43 | 3222 | 177341 | 156235 | 63152224 |
Wound | 3062.73 | 54.43 | 2991 | 177572 | 160272 | 63148187 |
Alopecia | 2876.99 | 54.43 | 4125 | 176438 | 333411 | 62975048 |
Pericarditis | 2665.49 | 54.43 | 2516 | 178047 | 129063 | 63179396 |
Arthropathy | 2654.89 | 54.43 | 3297 | 177266 | 231495 | 63076964 |
Discomfort | 2620.41 | 54.43 | 2782 | 177781 | 164592 | 63143867 |
Abdominal discomfort | 2582.49 | 54.43 | 3818 | 176745 | 317067 | 62991392 |
Contraindicated product administered | 2540.23 | 54.43 | 3106 | 177457 | 214542 | 63093917 |
Synovitis | 2523.00 | 54.43 | 2874 | 177689 | 184044 | 63124415 |
Swelling | 2504.65 | 54.43 | 3474 | 177089 | 271904 | 63036555 |
Anti-cyclic citrullinated peptide antibody positive | 2489.74 | 54.43 | 2293 | 178270 | 113919 | 63194540 |
Drug intolerance | 2012.52 | 54.43 | 3336 | 177227 | 305325 | 63003134 |
Duodenal ulcer perforation | 1801.07 | 54.43 | 1687 | 178876 | 85522 | 63222937 |
Helicobacter infection | 1697.36 | 54.43 | 1679 | 178884 | 91106 | 63217353 |
Hepatic enzyme increased | 1632.37 | 54.43 | 2414 | 178149 | 199914 | 63108545 |
Infusion related reaction | 1579.82 | 54.43 | 2640 | 177923 | 242881 | 63065578 |
Maternal exposure during pregnancy | 1554.90 | 54.43 | 2469 | 178094 | 217593 | 63090866 |
Rheumatoid factor positive | 1367.73 | 54.43 | 1431 | 179132 | 82975 | 63225484 |
Product use issue | 1346.04 | 54.43 | 2317 | 178246 | 218203 | 63090256 |
Hypersensitivity | 1300.27 | 54.43 | 2684 | 177879 | 290001 | 63018458 |
Joint swelling | 1223.21 | 54.43 | 2801 | 177762 | 324865 | 62983594 |
Treatment failure | 1147.35 | 54.43 | 2040 | 178523 | 197003 | 63111456 |
Pain | 1007.04 | 54.43 | 4459 | 176104 | 736169 | 62572290 |
Therapeutic product effect decreased | 973.47 | 54.43 | 1869 | 178694 | 191318 | 63117141 |
Rheumatic fever | 910.20 | 54.43 | 845 | 179718 | 42266 | 63266193 |
Folliculitis | 898.22 | 54.43 | 1053 | 179510 | 69264 | 63239195 |
Blister | 892.34 | 54.43 | 1440 | 179123 | 128374 | 63180085 |
Death | 889.87 | 54.43 | 42 | 180521 | 374339 | 62934120 |
Muscle injury | 870.54 | 54.43 | 1000 | 179563 | 64345 | 63244114 |
Irritable bowel syndrome | 788.04 | 54.43 | 1068 | 179495 | 81344 | 63227115 |
Swollen joint count increased | 740.44 | 54.43 | 696 | 179867 | 35358 | 63273101 |
Acute kidney injury | 731.14 | 54.43 | 3 | 180560 | 263412 | 63045047 |
Sleep disorder due to general medical condition, insomnia type | 725.75 | 54.43 | 817 | 179746 | 51400 | 63257059 |
Drug ineffective | 666.63 | 54.43 | 5149 | 175414 | 1039616 | 62268843 |
Toxicity to various agents | 660.71 | 54.43 | 8 | 180555 | 247242 | 63061217 |
Impaired healing | 652.45 | 54.43 | 1099 | 179464 | 101443 | 63207016 |
Blood cholesterol increased | 641.54 | 54.43 | 1040 | 179523 | 92992 | 63215467 |
Liver injury | 600.81 | 54.43 | 799 | 179764 | 59721 | 63248738 |
Psoriatic arthropathy | 587.65 | 54.43 | 985 | 179578 | 90535 | 63217924 |
Hypotension | 586.95 | 54.43 | 51 | 180512 | 272553 | 63035906 |
Drug interaction | 585.01 | 54.43 | 14 | 180549 | 229117 | 63079342 |
Type 2 diabetes mellitus | 574.72 | 54.43 | 804 | 179759 | 63064 | 63245395 |
Fall | 560.70 | 54.43 | 208 | 180355 | 392126 | 62916333 |
Hip arthroplasty | 535.54 | 54.43 | 669 | 179894 | 46977 | 63261482 |
Rash | 522.80 | 54.43 | 3042 | 177521 | 557829 | 62750630 |
Nausea | 490.92 | 54.43 | 1066 | 179497 | 853405 | 62455054 |
Knee arthroplasty | 475.21 | 54.43 | 674 | 179889 | 53532 | 63254927 |
Constipation | 450.73 | 54.43 | 55 | 180508 | 224888 | 63083571 |
Anaemia | 442.36 | 54.43 | 142 | 180421 | 293288 | 63015171 |
Fatigue | 436.01 | 54.43 | 4134 | 176429 | 883894 | 62424565 |
Dehydration | 419.40 | 54.43 | 17 | 180546 | 173337 | 63135122 |
Intentional product use issue | 408.15 | 54.43 | 1031 | 179532 | 126861 | 63181598 |
Ill-defined disorder | 401.07 | 54.43 | 783 | 179780 | 80972 | 63227487 |
Lower respiratory tract infection | 396.85 | 54.43 | 1042 | 179521 | 131265 | 63177194 |
Somnolence | 393.93 | 54.43 | 30 | 180533 | 178655 | 63129804 |
Sepsis | 392.07 | 54.43 | 9 | 180554 | 153114 | 63155345 |
Stomatitis | 390.35 | 54.43 | 1067 | 179496 | 137658 | 63170801 |
Musculoskeletal stiffness | 378.35 | 54.43 | 1270 | 179293 | 183348 | 63125111 |
Urinary tract infection | 371.63 | 54.43 | 144 | 180419 | 264540 | 63043919 |
Gastrointestinal disorder | 364.82 | 54.43 | 1005 | 179558 | 130234 | 63178225 |
Haemoglobin decreased | 363.31 | 54.43 | 11 | 180552 | 145474 | 63162985 |
Neutropenia | 357.45 | 54.43 | 40 | 180523 | 174965 | 63133494 |
Thrombocytopenia | 352.10 | 54.43 | 19 | 180544 | 151138 | 63157321 |
Diarrhoea | 345.46 | 54.43 | 975 | 179588 | 714391 | 62594068 |
Fibromyalgia | 343.14 | 54.43 | 727 | 179836 | 79693 | 63228766 |
General physical health deterioration | 341.39 | 54.43 | 1302 | 179261 | 200100 | 63108359 |
Infection | 335.29 | 54.43 | 1415 | 179148 | 227758 | 63080701 |
Product dose omission issue | 334.69 | 54.43 | 124 | 180439 | 234189 | 63074270 |
Back pain | 302.29 | 54.43 | 189 | 180374 | 263956 | 63044503 |
Seizure | 298.82 | 54.43 | 20 | 180543 | 132614 | 63175845 |
Febrile neutropenia | 295.57 | 54.43 | 9 | 180554 | 118440 | 63190019 |
Pulmonary embolism | 294.34 | 54.43 | 8 | 180555 | 116676 | 63191783 |
Tremor | 283.66 | 54.43 | 25 | 180538 | 132214 | 63176245 |
Cerebrovascular accident | 281.88 | 54.43 | 5 | 180558 | 108019 | 63200440 |
Pneumonia | 278.77 | 54.43 | 549 | 180014 | 456218 | 62852241 |
Syncope | 272.59 | 54.43 | 15 | 180548 | 117370 | 63191089 |
Arthralgia | 267.57 | 54.43 | 2631 | 177932 | 567079 | 62741380 |
Respiratory failure | 264.61 | 54.43 | 5 | 180558 | 101853 | 63206606 |
Cough | 254.91 | 54.43 | 274 | 180289 | 292469 | 63015990 |
Vomiting | 243.02 | 54.43 | 800 | 179763 | 558817 | 62749642 |
Cardiac failure congestive | 238.25 | 54.43 | 5 | 180558 | 92428 | 63216031 |
Platelet count decreased | 235.90 | 54.43 | 27 | 180536 | 116095 | 63192364 |
Feeling abnormal | 235.79 | 54.43 | 65 | 180498 | 148327 | 63160132 |
White blood cell count decreased | 234.40 | 54.43 | 54 | 180509 | 139050 | 63169409 |
Cardiac failure | 233.10 | 54.43 | 4 | 180559 | 89138 | 63219321 |
Overdose | 230.69 | 54.43 | 28 | 180535 | 115050 | 63193409 |
Hyperhidrosis | 229.61 | 54.43 | 21 | 180542 | 107815 | 63200644 |
Condition aggravated | 226.74 | 54.43 | 1933 | 178630 | 400284 | 62908175 |
Injection site pain | 221.49 | 54.43 | 49 | 180514 | 129751 | 63178708 |
Mobility decreased | 215.62 | 54.43 | 796 | 179767 | 120363 | 63188096 |
Blood creatinine increased | 214.46 | 54.43 | 8 | 180555 | 87836 | 63220623 |
Tachycardia | 211.15 | 54.43 | 40 | 180523 | 118116 | 63190343 |
Asthenia | 210.58 | 54.43 | 489 | 180074 | 383115 | 62925344 |
Adverse event | 210.49 | 54.43 | 540 | 180023 | 67019 | 63241440 |
Malignant neoplasm progression | 209.48 | 54.43 | 5 | 180558 | 82116 | 63226343 |
Contusion | 208.04 | 54.43 | 912 | 179651 | 149132 | 63159327 |
Gastrointestinal haemorrhage | 206.84 | 54.43 | 5 | 180558 | 81171 | 63227288 |
Myalgia | 206.67 | 54.43 | 79 | 180484 | 146450 | 63162009 |
Dysphagia | 206.65 | 54.43 | 11 | 180552 | 88574 | 63219885 |
Neuropathy peripheral | 199.91 | 54.43 | 40 | 180523 | 113627 | 63194832 |
Renal impairment | 197.01 | 54.43 | 14 | 180549 | 88341 | 63220118 |
Hypokalaemia | 192.31 | 54.43 | 32 | 180531 | 103772 | 63204687 |
Erythema | 191.13 | 54.43 | 133 | 180430 | 175618 | 63132841 |
Dizziness | 190.28 | 54.43 | 609 | 179954 | 429316 | 62879143 |
Flushing | 186.23 | 54.43 | 6 | 180557 | 75081 | 63233378 |
Palpitations | 179.87 | 54.43 | 49 | 180514 | 112721 | 63195738 |
Epistaxis | 179.70 | 54.43 | 6 | 180557 | 72719 | 63235740 |
Dyspnoea | 179.23 | 54.43 | 1125 | 179438 | 660188 | 62648271 |
Injury | 178.23 | 54.43 | 535 | 180028 | 72712 | 63235747 |
Vision blurred | 175.58 | 54.43 | 26 | 180537 | 91898 | 63216561 |
Chest discomfort | 174.98 | 54.43 | 48 | 180515 | 109921 | 63198538 |
Loss of consciousness | 174.53 | 54.43 | 59 | 180504 | 118062 | 63190397 |
Prescribed overdose | 173.34 | 54.43 | 332 | 180231 | 33821 | 63274638 |
Balance disorder | 173.04 | 54.43 | 19 | 180544 | 84403 | 63224056 |
Live birth | 169.84 | 54.43 | 280 | 180283 | 25350 | 63283109 |
Peripheral swelling | 169.54 | 54.43 | 1315 | 179248 | 264627 | 63043832 |
Pleural effusion | 163.48 | 54.43 | 33 | 180530 | 93177 | 63215282 |
Nasopharyngitis | 159.71 | 54.43 | 1253 | 179310 | 253004 | 63055455 |
COVID-19 | 159.43 | 54.43 | 61 | 180502 | 113042 | 63195417 |
Wrong technique in product usage process | 154.54 | 54.43 | 5 | 180558 | 62335 | 63246124 |
Injection site erythema | 144.72 | 54.43 | 30 | 180533 | 83144 | 63225315 |
Weight decreased | 144.50 | 54.43 | 362 | 180201 | 276436 | 63032023 |
Interstitial lung disease | 143.41 | 54.43 | 8 | 180555 | 61900 | 63246559 |
Chronic obstructive pulmonary disease | 142.48 | 54.43 | 9 | 180554 | 62677 | 63245782 |
Upper respiratory tract infection | 141.92 | 54.43 | 30 | 180533 | 82017 | 63226442 |
Thrombosis | 136.78 | 54.43 | 13 | 180550 | 64742 | 63243717 |
Grip strength decreased | 136.40 | 54.43 | 235 | 180328 | 22052 | 63286407 |
Deep vein thrombosis | 136.30 | 54.43 | 35 | 180528 | 83765 | 63224694 |
Suicide attempt | 134.80 | 54.43 | 10 | 180553 | 60908 | 63247551 |
Deep vein thrombosis postoperative | 134.68 | 54.43 | 164 | 180399 | 11205 | 63297254 |
Drug tolerance decreased | 133.86 | 54.43 | 204 | 180359 | 17269 | 63291190 |
Hallucination | 133.76 | 54.43 | 5 | 180558 | 54812 | 63253647 |
Anxiety | 133.65 | 54.43 | 260 | 180303 | 217281 | 63091178 |
Abdominal pain | 130.84 | 54.43 | 414 | 180149 | 293042 | 63015417 |
Suicidal ideation | 130.62 | 54.43 | 13 | 180550 | 62408 | 63246051 |
Hypoglycaemia | 129.73 | 54.43 | 11 | 180552 | 60054 | 63248405 |
Swelling face | 123.43 | 54.43 | 17 | 180546 | 63458 | 63245001 |
Atrial fibrillation | 123.17 | 54.43 | 91 | 180472 | 116545 | 63191914 |
Facet joint syndrome | 123.02 | 54.43 | 162 | 180401 | 11976 | 63296483 |
Lip dry | 121.89 | 54.43 | 183 | 180380 | 15287 | 63293172 |
Foot deformity | 121.26 | 54.43 | 254 | 180309 | 27599 | 63280860 |
Myocardial infarction | 120.44 | 54.43 | 67 | 180496 | 99826 | 63208633 |
Coma | 118.84 | 54.43 | 20 | 180543 | 64344 | 63244115 |
Adjustment disorder with depressed mood | 117.33 | 54.43 | 145 | 180418 | 10059 | 63298400 |
Prescribed underdose | 116.94 | 54.43 | 260 | 180303 | 29429 | 63279030 |
Blood pressure decreased | 114.05 | 54.43 | 23 | 180540 | 64999 | 63243460 |
Chills | 113.96 | 54.43 | 93 | 180470 | 113285 | 63195174 |
Abortion spontaneous | 112.82 | 54.43 | 5 | 180558 | 47190 | 63261269 |
Chronic kidney disease | 111.26 | 54.43 | 4 | 180559 | 45394 | 63263065 |
Pulmonary fibrosis | 110.58 | 54.43 | 305 | 180258 | 39504 | 63268955 |
Blood glucose increased | 110.25 | 54.43 | 50 | 180513 | 83706 | 63224753 |
Blood pressure increased | 109.08 | 54.43 | 183 | 180380 | 161879 | 63146580 |
Anti-cyclic citrullinated peptide antibody | 108.19 | 54.43 | 114 | 180449 | 6644 | 63301815 |
Agitation | 107.22 | 54.43 | 20 | 180543 | 59737 | 63248722 |
Adverse drug reaction | 106.20 | 54.43 | 479 | 180084 | 79235 | 63229224 |
X-ray abnormal | 105.98 | 54.43 | 123 | 180440 | 7987 | 63300472 |
Injection site swelling | 104.72 | 54.43 | 8 | 180555 | 47564 | 63260895 |
No adverse event | 103.78 | 54.43 | 3 | 180560 | 41402 | 63267057 |
Rash pruritic | 103.14 | 54.43 | 22 | 180541 | 59777 | 63248682 |
Cardiac disorder | 102.71 | 54.43 | 12 | 180551 | 50804 | 63257655 |
Colitis | 101.81 | 54.43 | 10 | 180553 | 48518 | 63259941 |
Red blood cell count decreased | 101.68 | 54.43 | 3 | 180560 | 40642 | 63267817 |
Sinusitis | 101.08 | 54.43 | 1037 | 179526 | 225616 | 63082843 |
Dysarthria | 100.56 | 54.43 | 5 | 180558 | 42706 | 63265753 |
Mucosal inflammation | 100.24 | 54.43 | 9 | 180554 | 46919 | 63261540 |
Staphylococcal infection | 99.85 | 54.43 | 4 | 180559 | 41252 | 63267207 |
Septic shock | 98.88 | 54.43 | 33 | 180530 | 66596 | 63241863 |
Oxygen saturation decreased | 97.62 | 54.43 | 66 | 180497 | 88519 | 63219940 |
Dysgeusia | 97.02 | 54.43 | 10 | 180553 | 46700 | 63261759 |
Alanine aminotransferase increased | 96.00 | 54.43 | 92 | 180471 | 103678 | 63204781 |
Influenza like illness | 95.90 | 54.43 | 35 | 180528 | 66789 | 63241670 |
Aspartate aminotransferase increased | 94.58 | 54.43 | 71 | 180492 | 90206 | 63218253 |
Fluid retention | 93.17 | 54.43 | 27 | 180536 | 59659 | 63248800 |
Confusional state | 93.10 | 54.43 | 1055 | 179508 | 235325 | 63073134 |
Haemorrhage | 92.72 | 54.43 | 29 | 180534 | 60993 | 63247466 |
Unevaluable event | 92.62 | 54.43 | 17 | 180546 | 51369 | 63257090 |
Gastritis | 92.42 | 54.43 | 3 | 180560 | 37300 | 63271159 |
Peripheral venous disease | 91.85 | 54.43 | 161 | 180402 | 15316 | 63293143 |
Disturbance in attention | 91.43 | 54.43 | 4 | 180559 | 38185 | 63270274 |
Retinitis | 91.25 | 54.43 | 100 | 180463 | 6096 | 63302363 |
Joint range of motion decreased | 90.61 | 54.43 | 249 | 180314 | 32179 | 63276280 |
Depression | 90.48 | 54.43 | 273 | 180290 | 196219 | 63112240 |
Dislocation of vertebra | 90.24 | 54.43 | 117 | 180446 | 8518 | 63299941 |
Bronchitis | 89.81 | 54.43 | 135 | 180428 | 124800 | 63183659 |
C-reactive protein abnormal | 89.71 | 54.43 | 312 | 180251 | 45784 | 63262675 |
Dyspnoea exertional | 89.25 | 54.43 | 30 | 180533 | 60272 | 63248187 |
Femur fracture | 89.21 | 54.43 | 8 | 180555 | 41748 | 63266711 |
Intentional product misuse | 88.96 | 54.43 | 31 | 180532 | 60886 | 63247573 |
Autoimmune disorder | 88.40 | 54.43 | 168 | 180395 | 17009 | 63291450 |
Weight increased | 87.89 | 54.43 | 1130 | 179433 | 259662 | 63048797 |
Hospitalisation | 87.74 | 54.43 | 68 | 180495 | 85013 | 63223446 |
Oedema peripheral | 86.76 | 54.43 | 264 | 180299 | 189247 | 63119212 |
Cellulitis | 86.45 | 54.43 | 64 | 180499 | 81894 | 63226565 |
Anaphylactic reaction | 86.15 | 54.43 | 40 | 180523 | 66060 | 63242399 |
Anticipatory anxiety | 85.71 | 54.43 | 50 | 180513 | 1201 | 63307258 |
Hepatic failure | 84.50 | 54.43 | 4 | 180559 | 35652 | 63272807 |
Transient ischaemic attack | 84.09 | 54.43 | 6 | 180557 | 37747 | 63270712 |
Breast cancer | 83.03 | 54.43 | 18 | 180545 | 48365 | 63260094 |
Lethargy | 82.65 | 54.43 | 28 | 180535 | 55979 | 63252480 |
Influenza | 81.56 | 54.43 | 114 | 180449 | 108608 | 63199851 |
Drug use disorder | 81.44 | 54.43 | 85 | 180478 | 4899 | 63303560 |
Neoplasm progression | 80.54 | 54.43 | 6 | 180557 | 36422 | 63272037 |
Respiratory distress | 79.85 | 54.43 | 4 | 180559 | 33947 | 63274512 |
Arrhythmia | 79.64 | 54.43 | 8 | 180555 | 38132 | 63270327 |
Chest pain | 79.41 | 54.43 | 330 | 180233 | 215629 | 63092830 |
Muscle spasms | 79.24 | 54.43 | 207 | 180356 | 155943 | 63152516 |
Pain in jaw | 79.23 | 54.43 | 14 | 180549 | 43482 | 63264977 |
Systemic lupus erythematosus rash | 78.42 | 54.43 | 59 | 180504 | 2193 | 63306266 |
Lymphadenopathy | 77.93 | 54.43 | 9 | 180554 | 38449 | 63270010 |
Urinary incontinence | 77.83 | 54.43 | 3 | 180560 | 32011 | 63276448 |
Injection site pruritus | 76.98 | 54.43 | 17 | 180546 | 45099 | 63263360 |
Blepharospasm | 76.78 | 54.43 | 90 | 180473 | 5906 | 63302553 |
Hot flush | 76.51 | 54.43 | 25 | 180538 | 51134 | 63257325 |
Bone pain | 76.10 | 54.43 | 30 | 180533 | 54611 | 63253848 |
Skin ulcer | 75.96 | 54.43 | 15 | 180548 | 43030 | 63265429 |
Abdominal distension | 75.32 | 54.43 | 81 | 180482 | 86534 | 63221925 |
Dry skin | 74.80 | 54.43 | 34 | 180529 | 56853 | 63251606 |
Pneumonitis | 74.57 | 54.43 | 7 | 180556 | 35215 | 63273244 |
Foetal exposure during pregnancy | 74.43 | 54.43 | 4 | 180559 | 31958 | 63276501 |
Cholelithiasis | 74.05 | 54.43 | 17 | 180546 | 43908 | 63264551 |
Heart rate increased | 73.53 | 54.43 | 96 | 180467 | 94142 | 63214317 |
Lupus vulgaris | 73.50 | 54.43 | 88 | 180475 | 5906 | 63302553 |
Flatulence | 73.19 | 54.43 | 7 | 180556 | 34695 | 63273764 |
Depressed mood | 73.07 | 54.43 | 13 | 180550 | 40178 | 63268281 |
Emotional distress | 73.00 | 54.43 | 5 | 180558 | 32544 | 63275915 |
Hypophagia | 72.52 | 54.43 | 4 | 180559 | 31255 | 63277204 |
Maternal exposure timing unspecified | 72.46 | 54.43 | 95 | 180468 | 6992 | 63301467 |
Skin exfoliation | 72.03 | 54.43 | 17 | 180546 | 43085 | 63265374 |
Pancreatitis | 71.57 | 54.43 | 25 | 180538 | 49030 | 63259429 |
Malaise | 71.23 | 54.43 | 798 | 179765 | 415156 | 62893303 |
Blood alkaline phosphatase increased | 69.75 | 54.43 | 18 | 180545 | 42949 | 63265510 |
Angioedema | 69.03 | 54.43 | 25 | 180538 | 47940 | 63260519 |
Drug ineffective for unapproved indication | 68.95 | 54.43 | 8 | 180555 | 34055 | 63274404 |
Haemoptysis | 68.80 | 54.43 | 3 | 180560 | 28723 | 63279736 |
Rash erythematous | 68.65 | 54.43 | 18 | 180545 | 42492 | 63265967 |
Exposure during pregnancy | 68.48 | 54.43 | 710 | 179853 | 154837 | 63153622 |
Transaminases increased | 67.03 | 54.43 | 6 | 180557 | 31361 | 63277098 |
Urinary retention | 66.96 | 54.43 | 5 | 180558 | 30296 | 63278163 |
Diabetes mellitus | 66.44 | 54.43 | 38 | 180525 | 55772 | 63252687 |
Headache | 66.28 | 54.43 | 1337 | 179226 | 631904 | 62676555 |
Presyncope | 66.22 | 54.43 | 3 | 180560 | 27782 | 63280677 |
Vaginal haemorrhage | 65.41 | 54.43 | 3 | 180560 | 27484 | 63280975 |
Loss of personal independence in daily activities | 64.58 | 54.43 | 486 | 180077 | 96804 | 63211655 |
Vertigo | 64.15 | 54.43 | 46 | 180517 | 59841 | 63248618 |
Haematuria | 63.90 | 54.43 | 5 | 180558 | 29152 | 63279307 |
Sleep apnoea syndrome | 63.83 | 54.43 | 5 | 180558 | 29128 | 63279331 |
Rectal haemorrhage | 63.38 | 54.43 | 30 | 180533 | 49000 | 63259459 |
Product prescribing error | 62.13 | 54.43 | 3 | 180560 | 26286 | 63282173 |
Jaundice | 61.43 | 54.43 | 6 | 180557 | 29245 | 63279214 |
Skin discolouration | 61.12 | 54.43 | 16 | 180547 | 37812 | 63270647 |
Breast cancer stage III | 60.28 | 54.43 | 107 | 180456 | 10279 | 63298180 |
Swollen tongue | 59.60 | 54.43 | 13 | 180550 | 34787 | 63273672 |
Fungal infection | 58.81 | 54.43 | 16 | 180547 | 36858 | 63271601 |
Surgery | 58.38 | 54.43 | 15 | 180548 | 35897 | 63272562 |
Mental disorder | 58.07 | 54.43 | 4 | 180559 | 25915 | 63282544 |
Angina pectoris | 56.29 | 54.43 | 9 | 180554 | 30069 | 63278390 |
Soft tissue disorder | 56.00 | 54.43 | 66 | 180497 | 4356 | 63304103 |
Pneumonia viral | 55.81 | 54.43 | 89 | 180474 | 7833 | 63300626 |
Lower limb fracture | 55.22 | 54.43 | 173 | 180390 | 24048 | 63284411 |
Aggression | 54.53 | 54.43 | 3 | 180560 | 23495 | 63284964 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Bone cyst | 296.91 | 33.75 | 74 | 10796 | 1526 | 34944535 |
Onychoclasis | 260.27 | 33.75 | 69 | 10801 | 1831 | 34944230 |
Drug ineffective | 246.95 | 33.75 | 476 | 10394 | 456275 | 34489786 |
Bone erosion | 229.57 | 33.75 | 74 | 10796 | 3941 | 34942120 |
Lymphoma | 229.02 | 33.75 | 100 | 10770 | 12407 | 34933654 |
Synovitis | 227.21 | 33.75 | 103 | 10767 | 13963 | 34932098 |
Drug intolerance | 224.21 | 33.75 | 169 | 10701 | 59401 | 34886660 |
Anti-cyclic citrullinated peptide antibody positive | 210.52 | 33.75 | 58 | 10812 | 1785 | 34944276 |
Joint ankylosis | 205.40 | 33.75 | 55 | 10815 | 1517 | 34944544 |
Tooth loss | 203.92 | 33.75 | 67 | 10803 | 3791 | 34942270 |
Osteolysis | 167.69 | 33.75 | 55 | 10815 | 3093 | 34942968 |
Joint swelling | 163.75 | 33.75 | 141 | 10729 | 59749 | 34886312 |
Red blood cell sedimentation rate abnormal | 160.62 | 33.75 | 55 | 10815 | 3534 | 34942527 |
Alopecia | 155.75 | 33.75 | 96 | 10774 | 24259 | 34921802 |
Alanine aminotransferase abnormal | 153.57 | 33.75 | 57 | 10813 | 4631 | 34941430 |
Arthropathy | 139.67 | 33.75 | 93 | 10777 | 26814 | 34919247 |
Rheumatoid arthritis | 129.49 | 33.75 | 102 | 10768 | 38136 | 34907925 |
Musculoskeletal stiffness | 127.72 | 33.75 | 110 | 10760 | 46570 | 34899491 |
Arthralgia | 125.37 | 33.75 | 204 | 10666 | 169837 | 34776224 |
C-reactive protein abnormal | 122.57 | 33.75 | 58 | 10812 | 8652 | 34937409 |
Drug specific antibody present | 115.19 | 33.75 | 42 | 10828 | 3243 | 34942818 |
Psoriatic arthropathy | 113.89 | 33.75 | 73 | 10797 | 19725 | 34926336 |
Neoplasm malignant | 111.06 | 33.75 | 72 | 10798 | 19833 | 34926228 |
Death | 106.71 | 33.75 | 4 | 10866 | 398045 | 34548016 |
Contraindicated product administered | 103.69 | 33.75 | 71 | 10799 | 21410 | 34924651 |
Drug tolerance decreased | 103.27 | 33.75 | 34 | 10836 | 1933 | 34944128 |
Treatment failure | 96.38 | 33.75 | 94 | 10776 | 46603 | 34899458 |
Therapeutic product effect decreased | 93.21 | 33.75 | 81 | 10789 | 34662 | 34911399 |
Drug use disorder | 91.53 | 33.75 | 38 | 10832 | 4153 | 34941908 |
Inappropriate schedule of product administration | 82.17 | 33.75 | 99 | 10771 | 62197 | 34883864 |
Pain | 77.81 | 33.75 | 186 | 10684 | 204489 | 34741572 |
Hepatic steatosis | 77.68 | 33.75 | 56 | 10814 | 18306 | 34927755 |
Ankle deformity | 75.30 | 33.75 | 17 | 10853 | 224 | 34945837 |
Mobility decreased | 70.42 | 33.75 | 65 | 10805 | 30063 | 34915998 |
Diabetes mellitus | 64.26 | 33.75 | 76 | 10794 | 46797 | 34899264 |
Skin injury | 64.12 | 33.75 | 25 | 10845 | 2320 | 34943741 |
Hypertension | 62.92 | 33.75 | 134 | 10736 | 136309 | 34809752 |
Body temperature decreased | 62.68 | 33.75 | 43 | 10827 | 12991 | 34933070 |
Arthritis | 62.58 | 33.75 | 62 | 10808 | 31284 | 34914777 |
Therapeutic response decreased | 62.30 | 33.75 | 60 | 10810 | 29253 | 34916808 |
Intentional product use issue | 59.93 | 33.75 | 83 | 10787 | 59733 | 34886328 |
Upper respiratory tract infection | 56.24 | 33.75 | 60 | 10810 | 32999 | 34913062 |
Wrist deformity | 53.38 | 33.75 | 14 | 10856 | 355 | 34945706 |
Hand deformity | 52.98 | 33.75 | 25 | 10845 | 3700 | 34942361 |
Drug-induced liver injury | 52.02 | 33.75 | 54 | 10816 | 28778 | 34917283 |
Heart rate decreased | 51.17 | 33.75 | 56 | 10814 | 31689 | 34914372 |
Blood pressure fluctuation | 50.50 | 33.75 | 50 | 10820 | 25199 | 34920862 |
Therapeutic product effect incomplete | 50.42 | 33.75 | 70 | 10800 | 50471 | 34895590 |
Drug interaction | 49.69 | 33.75 | 6 | 10864 | 225940 | 34720121 |
Hepatic fibrosis | 47.94 | 33.75 | 25 | 10845 | 4582 | 34941479 |
Allergy to animal | 47.29 | 33.75 | 13 | 10857 | 396 | 34945665 |
Bladder transitional cell carcinoma | 44.59 | 33.75 | 20 | 10850 | 2635 | 34943426 |
Anaemia | 42.92 | 33.75 | 10 | 10860 | 233325 | 34712736 |
Gastrointestinal infection | 42.57 | 33.75 | 25 | 10845 | 5773 | 34940288 |
Blood pressure systolic increased | 39.63 | 33.75 | 42 | 10828 | 22910 | 34923151 |
Blood pressure increased | 38.79 | 33.75 | 85 | 10785 | 88017 | 34858044 |
Aortic bruit | 38.53 | 33.75 | 10 | 10860 | 243 | 34945818 |
Chronic sinusitis | 37.74 | 33.75 | 17 | 10853 | 2262 | 34943799 |
Gait inability | 37.65 | 33.75 | 39 | 10831 | 20719 | 34925342 |
Rhinorrhoea | 37.45 | 33.75 | 43 | 10827 | 25625 | 34920436 |
Condition aggravated | 36.69 | 33.75 | 137 | 10733 | 192059 | 34754002 |
Nasal polyps | 36.22 | 33.75 | 17 | 10853 | 2486 | 34943575 |
Toxicity to various agents | 36.02 | 33.75 | 9 | 10861 | 200353 | 34745708 |
Therapeutic response shortened | 34.58 | 33.75 | 24 | 10846 | 7380 | 34938681 |
Elbow operation | 33.81 | 33.75 | 8 | 10862 | 131 | 34945930 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Pemphigus | 3220.15 | 44.20 | 2058 | 136754 | 97524 | 79508052 |
Systemic lupus erythematosus | 2943.48 | 44.20 | 2097 | 136715 | 119052 | 79486524 |
Glossodynia | 2895.85 | 44.20 | 1953 | 136859 | 101384 | 79504192 |
Hand deformity | 2859.60 | 44.20 | 1942 | 136870 | 101977 | 79503599 |
Synovitis | 2552.85 | 44.20 | 2105 | 136707 | 148629 | 79456947 |
Anti-cyclic citrullinated peptide antibody positive | 2360.91 | 44.20 | 1585 | 137227 | 81558 | 79524018 |
Pericarditis | 2352.09 | 44.20 | 1726 | 137086 | 102510 | 79503066 |
Alopecia | 2254.50 | 44.20 | 2374 | 136438 | 228981 | 79376595 |
Wound | 2219.98 | 44.20 | 1742 | 137070 | 114437 | 79491139 |
Arthropathy | 2052.69 | 44.20 | 1997 | 136815 | 175114 | 79430462 |
Drug intolerance | 2047.84 | 44.20 | 2405 | 136407 | 261714 | 79343862 |
Discomfort | 1902.61 | 44.20 | 1646 | 137166 | 123971 | 79481605 |
Swelling | 1898.54 | 44.20 | 2103 | 136709 | 214608 | 79390968 |
Contraindicated product administered | 1888.46 | 44.20 | 1810 | 137002 | 155728 | 79449848 |
Abdominal discomfort | 1807.98 | 44.20 | 2201 | 136611 | 248526 | 79357050 |
Duodenal ulcer perforation | 1738.09 | 44.20 | 1203 | 137609 | 65008 | 79540568 |
Helicobacter infection | 1659.30 | 44.20 | 1193 | 137619 | 68511 | 79537065 |
Hepatic enzyme increased | 1409.92 | 44.20 | 1661 | 137151 | 180949 | 79424627 |
Joint swelling | 1403.61 | 44.20 | 2092 | 136720 | 286554 | 79319022 |
Hypersensitivity | 1286.50 | 44.20 | 1909 | 136903 | 260330 | 79345246 |
Therapeutic product effect decreased | 1209.30 | 44.20 | 1457 | 137355 | 162406 | 79443170 |
Maternal exposure during pregnancy | 1209.23 | 44.20 | 1334 | 137478 | 135204 | 79470372 |
Rheumatoid factor positive | 1192.90 | 44.20 | 921 | 137891 | 58918 | 79546658 |
Infusion related reaction | 1164.81 | 44.20 | 1701 | 137111 | 228536 | 79377040 |
Folliculitis | 1087.77 | 44.20 | 845 | 137967 | 54535 | 79551041 |
Muscle injury | 1064.15 | 44.20 | 791 | 138021 | 47770 | 79557806 |
Irritable bowel syndrome | 1027.83 | 44.20 | 858 | 137954 | 61383 | 79544193 |
Blister | 1026.09 | 44.20 | 1149 | 137663 | 118327 | 79487249 |
Treatment failure | 1023.44 | 44.20 | 1368 | 137444 | 169118 | 79436458 |
Sleep disorder due to general medical condition, insomnia type | 924.24 | 44.20 | 696 | 138116 | 42860 | 79562716 |
Acute kidney injury | 886.95 | 44.20 | 3 | 138809 | 519401 | 79086175 |
Impaired healing | 835.85 | 44.20 | 891 | 137921 | 86764 | 79518812 |
Death | 830.93 | 44.20 | 37 | 138775 | 566477 | 79039099 |
Pain | 823.75 | 44.20 | 2888 | 135924 | 700914 | 78904662 |
Rheumatic fever | 742.41 | 44.20 | 516 | 138296 | 28009 | 79577567 |
Toxicity to various agents | 678.47 | 44.20 | 11 | 138801 | 421529 | 79184047 |
Product use issue | 660.96 | 44.20 | 1254 | 137558 | 208568 | 79397008 |
Drug interaction | 632.75 | 44.20 | 20 | 138792 | 415163 | 79190413 |
Drug ineffective | 615.02 | 44.20 | 3580 | 135232 | 1077333 | 78528243 |
Swollen joint count increased | 569.25 | 44.20 | 403 | 138409 | 22524 | 79583052 |
Arthralgia | 565.69 | 44.20 | 2225 | 136587 | 569578 | 79035998 |
Hip arthroplasty | 553.20 | 44.20 | 475 | 138337 | 35281 | 79570295 |
Fibromyalgia | 543.64 | 44.20 | 614 | 138198 | 63726 | 79541850 |
Hypotension | 521.21 | 44.20 | 74 | 138738 | 440243 | 79165333 |
Stomatitis | 519.72 | 44.20 | 923 | 137889 | 145834 | 79459742 |
Psoriatic arthropathy | 518.81 | 44.20 | 659 | 138153 | 77340 | 79528236 |
Blood cholesterol increased | 512.64 | 44.20 | 679 | 138133 | 83041 | 79522535 |
Knee arthroplasty | 494.40 | 44.20 | 485 | 138327 | 42763 | 79562813 |
Lower respiratory tract infection | 490.44 | 44.20 | 838 | 137974 | 128382 | 79477194 |
Ill-defined disorder | 487.03 | 44.20 | 587 | 138225 | 65288 | 79540288 |
Infection | 485.87 | 44.20 | 1205 | 137607 | 240507 | 79365069 |
Gastrointestinal disorder | 465.71 | 44.20 | 794 | 138018 | 121411 | 79484165 |
Anaemia | 445.70 | 44.20 | 113 | 138699 | 444902 | 79160674 |
Musculoskeletal stiffness | 437.76 | 44.20 | 951 | 137861 | 174057 | 79431519 |
Type 2 diabetes mellitus | 432.07 | 44.20 | 515 | 138297 | 56607 | 79548969 |
Sepsis | 399.69 | 44.20 | 16 | 138796 | 269412 | 79336164 |
Neutropenia | 387.17 | 44.20 | 30 | 138782 | 287680 | 79317896 |
Thrombocytopenia | 373.47 | 44.20 | 22 | 138790 | 265237 | 79340339 |
Intentional product use issue | 366.04 | 44.20 | 814 | 137998 | 151298 | 79454278 |
Febrile neutropenia | 352.07 | 44.20 | 11 | 138801 | 230988 | 79374588 |
Dehydration | 336.38 | 44.20 | 25 | 138787 | 248162 | 79357414 |
Nasopharyngitis | 326.65 | 44.20 | 1078 | 137734 | 252803 | 79352773 |
Rash | 325.42 | 44.20 | 1914 | 136898 | 576444 | 79029132 |
Peripheral swelling | 318.05 | 44.20 | 1112 | 137700 | 268505 | 79337071 |
Liver injury | 315.81 | 44.20 | 439 | 138373 | 56175 | 79549401 |
Mobility decreased | 315.73 | 44.20 | 673 | 138139 | 121502 | 79484074 |
Sinusitis | 314.77 | 44.20 | 898 | 137914 | 194603 | 79410973 |
Haemoglobin decreased | 307.90 | 44.20 | 20 | 138792 | 222099 | 79383477 |
Constipation | 304.95 | 44.20 | 61 | 138751 | 282989 | 79322587 |
Disease progression | 304.27 | 44.20 | 3 | 138809 | 184359 | 79421217 |
Fall | 303.21 | 44.20 | 243 | 138569 | 487386 | 79118190 |
Renal failure | 301.19 | 44.20 | 11 | 138801 | 200957 | 79404619 |
Respiratory failure | 289.55 | 44.20 | 5 | 138807 | 180906 | 79424670 |
Pneumonia | 285.78 | 44.20 | 443 | 138369 | 659803 | 78945773 |
Contusion | 280.07 | 44.20 | 724 | 138088 | 148052 | 79457524 |
Somnolence | 273.65 | 44.20 | 44 | 138768 | 238937 | 79366639 |
Seizure | 255.89 | 44.20 | 19 | 138793 | 188815 | 79416761 |
Weight increased | 255.19 | 44.20 | 1057 | 137755 | 276329 | 79329247 |
Pulmonary embolism | 255.13 | 44.20 | 10 | 138802 | 171644 | 79433932 |
Adverse event | 253.01 | 44.20 | 409 | 138403 | 59805 | 79545771 |
Foot deformity | 253.00 | 44.20 | 258 | 138554 | 23816 | 79581760 |
Platelet count decreased | 241.39 | 44.20 | 28 | 138784 | 194636 | 79410940 |
Cardiac failure | 240.96 | 44.20 | 6 | 138806 | 154836 | 79450740 |
Fatigue | 237.45 | 44.20 | 2564 | 136248 | 927163 | 78678413 |
Renal impairment | 228.51 | 44.20 | 11 | 138801 | 157772 | 79447804 |
Cerebrovascular accident | 227.59 | 44.20 | 10 | 138802 | 155282 | 79450294 |
Cardiac failure congestive | 227.59 | 44.20 | 4 | 138808 | 142398 | 79463178 |
Blood creatinine increased | 227.20 | 44.20 | 10 | 138802 | 155047 | 79450529 |
C-reactive protein abnormal | 224.63 | 44.20 | 344 | 138468 | 48023 | 79557553 |
Overdose | 219.88 | 44.20 | 30 | 138782 | 184176 | 79421400 |
Condition aggravated | 216.76 | 44.20 | 1553 | 137259 | 499571 | 79106005 |
Gastrointestinal haemorrhage | 199.72 | 44.20 | 15 | 138797 | 147704 | 79457872 |
Injury | 195.62 | 44.20 | 423 | 138389 | 77073 | 79528503 |
Deep vein thrombosis postoperative | 191.46 | 44.20 | 155 | 138657 | 10597 | 79594979 |
Syncope | 188.38 | 44.20 | 41 | 138771 | 179408 | 79426168 |
Prescribed overdose | 188.10 | 44.20 | 278 | 138534 | 37605 | 79567971 |
Malignant neoplasm progression | 186.18 | 44.20 | 13 | 138799 | 135977 | 79469599 |
Facet joint syndrome | 184.68 | 44.20 | 155 | 138657 | 11147 | 79594429 |
White blood cell count decreased | 180.30 | 44.20 | 52 | 138760 | 188236 | 79417340 |
Lip dry | 180.04 | 44.20 | 175 | 138637 | 15243 | 79590333 |
Grip strength decreased | 173.28 | 44.20 | 202 | 138610 | 21667 | 79583909 |
Bone erosion | 170.90 | 44.20 | 182 | 138630 | 17665 | 79587911 |
Tachycardia | 168.55 | 44.20 | 50 | 138762 | 177718 | 79427858 |
Tremor | 168.41 | 44.20 | 44 | 138768 | 170039 | 79435537 |
Interstitial lung disease | 165.81 | 44.20 | 7 | 138805 | 112593 | 79492983 |
Hyperhidrosis | 160.25 | 44.20 | 34 | 138778 | 151458 | 79454118 |
Vomiting | 159.86 | 44.20 | 608 | 138204 | 665220 | 78940356 |
Dysphagia | 157.97 | 44.20 | 15 | 138797 | 122121 | 79483455 |
General physical health deterioration | 157.45 | 44.20 | 916 | 137896 | 274322 | 79331254 |
Nausea | 156.24 | 44.20 | 1002 | 137810 | 956194 | 78649382 |
Adjustment disorder with depressed mood | 153.42 | 44.20 | 127 | 138685 | 8959 | 79596617 |
Live birth | 153.32 | 44.20 | 176 | 138636 | 18568 | 79587008 |
Hypokalaemia | 153.03 | 44.20 | 32 | 138780 | 144008 | 79461568 |
Product dose omission issue | 151.54 | 44.20 | 125 | 138687 | 247412 | 79358164 |
Urinary tract infection | 147.59 | 44.20 | 156 | 138656 | 274356 | 79331220 |
Joint range of motion decreased | 146.54 | 44.20 | 231 | 138581 | 33051 | 79572525 |
Drug use disorder | 146.24 | 44.20 | 121 | 138691 | 8530 | 79597046 |
Adverse drug reaction | 144.80 | 44.20 | 342 | 138470 | 66050 | 79539526 |
Myocardial infarction | 144.24 | 44.20 | 70 | 138742 | 184059 | 79421517 |
Autoimmune disorder | 140.99 | 44.20 | 159 | 138653 | 16453 | 79589123 |
Electrocardiogram QT prolonged | 138.73 | 44.20 | 4 | 138808 | 90382 | 79515194 |
Anti-cyclic citrullinated peptide antibody | 136.35 | 44.20 | 99 | 138713 | 5753 | 79599823 |
Peripheral venous disease | 136.27 | 44.20 | 153 | 138659 | 15756 | 79589820 |
Hypoglycaemia | 135.39 | 44.20 | 11 | 138801 | 101583 | 79503993 |
Pulmonary oedema | 135.11 | 44.20 | 4 | 138808 | 88250 | 79517326 |
Atrial fibrillation | 133.90 | 44.20 | 90 | 138722 | 197796 | 79407780 |
Neuropathy peripheral | 131.67 | 44.20 | 41 | 138771 | 141264 | 79464312 |
Pleural effusion | 130.34 | 44.20 | 45 | 138767 | 145217 | 79460359 |
Hallucination | 127.35 | 44.20 | 5 | 138807 | 85740 | 79519836 |
Retinitis | 125.90 | 44.20 | 93 | 138719 | 5550 | 79600026 |
Coma | 123.43 | 44.20 | 15 | 138797 | 100634 | 79504942 |
Loss of consciousness | 119.63 | 44.20 | 72 | 138740 | 167871 | 79437705 |
Septic shock | 119.22 | 44.20 | 33 | 138779 | 122768 | 79482808 |
Red blood cell sedimentation rate increased | 118.46 | 44.20 | 253 | 138559 | 45689 | 79559887 |
Exposure during pregnancy | 118.00 | 44.20 | 416 | 138396 | 100716 | 79504860 |
Epistaxis | 117.98 | 44.20 | 25 | 138787 | 111490 | 79494086 |
Maternal exposure timing unspecified | 117.12 | 44.20 | 90 | 138722 | 5702 | 79599874 |
Diarrhoea | 115.97 | 44.20 | 979 | 137833 | 879510 | 78726066 |
Myalgia | 114.51 | 44.20 | 93 | 138719 | 185548 | 79420028 |
Hypoaesthesia | 113.13 | 44.20 | 613 | 138199 | 178739 | 79426837 |
Agitation | 112.63 | 44.20 | 19 | 138793 | 99696 | 79505880 |
Osteoarthritis | 111.36 | 44.20 | 370 | 138442 | 86939 | 79518637 |
Deep vein thrombosis | 111.02 | 44.20 | 36 | 138776 | 120883 | 79484693 |
Flushing | 108.61 | 44.20 | 13 | 138799 | 88255 | 79517321 |
Dislocation of vertebra | 108.44 | 44.20 | 98 | 138714 | 7782 | 79597794 |
Lactic acidosis | 108.40 | 44.20 | 3 | 138809 | 70356 | 79535220 |
Dyspnoea | 108.34 | 44.20 | 963 | 137849 | 856062 | 78749514 |
Suicide attempt | 107.73 | 44.20 | 10 | 138802 | 82922 | 79522654 |
Anticipatory anxiety | 107.55 | 44.20 | 49 | 138763 | 1155 | 79604421 |
Rheumatoid arthritis | 107.16 | 44.20 | 675 | 138137 | 207795 | 79397781 |
Red blood cell sedimentation rate abnormal | 105.73 | 44.20 | 155 | 138657 | 20808 | 79584768 |
Systemic lupus erythematosus rash | 104.03 | 44.20 | 55 | 138757 | 1805 | 79603771 |
Pregnancy | 102.83 | 44.20 | 175 | 138637 | 26676 | 79578900 |
Lower limb fracture | 100.64 | 44.20 | 160 | 138652 | 23055 | 79582521 |
Cough | 100.60 | 44.20 | 316 | 138496 | 366473 | 79239103 |
Intentional product misuse | 99.31 | 44.20 | 22 | 138790 | 95143 | 79510433 |
Mental status changes | 99.11 | 44.20 | 4 | 138808 | 66955 | 79538621 |
Haematuria | 98.99 | 44.20 | 5 | 138807 | 68831 | 79536745 |
Blood bilirubin increased | 97.89 | 44.20 | 4 | 138808 | 66228 | 79539348 |
Arthritis | 97.84 | 44.20 | 428 | 138384 | 114452 | 79491124 |
Blood creatine phosphokinase increased | 97.65 | 44.20 | 4 | 138808 | 66086 | 79539490 |
Thrombosis | 97.28 | 44.20 | 15 | 138797 | 84085 | 79521491 |
Drug tolerance decreased | 96.40 | 44.20 | 116 | 138696 | 12862 | 79592714 |
Vision blurred | 96.39 | 44.20 | 32 | 138780 | 105866 | 79499710 |
COVID-19 | 95.98 | 44.20 | 80 | 138732 | 157594 | 79447982 |
Mucosal inflammation | 95.85 | 44.20 | 10 | 138802 | 75570 | 79530006 |
Wrong technique in product usage process | 95.71 | 44.20 | 9 | 138803 | 73866 | 79531710 |
Joint dislocation | 95.38 | 44.20 | 132 | 138680 | 16807 | 79588769 |
Back pain | 95.20 | 44.20 | 246 | 138566 | 303934 | 79301642 |
Chronic obstructive pulmonary disease | 94.89 | 44.20 | 17 | 138795 | 85402 | 79520174 |
Chronic kidney disease | 94.52 | 44.20 | 5 | 138807 | 66149 | 79539427 |
Ankle deformity | 93.32 | 44.20 | 38 | 138774 | 674 | 79604902 |
Suicidal ideation | 92.08 | 44.20 | 12 | 138800 | 76328 | 79529248 |
Bursitis | 91.96 | 44.20 | 197 | 138615 | 35647 | 79569929 |
Breast cancer stage III | 91.95 | 44.20 | 99 | 138713 | 9727 | 79595849 |
Chest discomfort | 91.74 | 44.20 | 64 | 138748 | 137980 | 79467596 |
Sciatica | 91.53 | 44.20 | 188 | 138624 | 33034 | 79572542 |
Hyperglycaemia | 89.99 | 44.20 | 9 | 138803 | 70326 | 79535250 |
Colitis | 87.29 | 44.20 | 12 | 138800 | 73295 | 79532281 |
Palpitations | 86.40 | 44.20 | 57 | 138755 | 126553 | 79479023 |
Hepatic failure | 86.29 | 44.20 | 5 | 138807 | 61207 | 79544369 |
Disorientation | 85.90 | 44.20 | 6 | 138806 | 62770 | 79542806 |
Balance disorder | 84.65 | 44.20 | 33 | 138779 | 98824 | 79506752 |
Respiratory distress | 84.65 | 44.20 | 4 | 138808 | 58335 | 79547241 |
Bone cyst | 84.38 | 44.20 | 60 | 138752 | 3373 | 79602203 |
Exostosis | 84.08 | 44.20 | 124 | 138688 | 16734 | 79588842 |
Acute respiratory failure | 83.52 | 44.20 | 5 | 138807 | 59536 | 79546040 |
X-ray abnormal | 83.37 | 44.20 | 74 | 138738 | 5739 | 79599837 |
Red blood cell count decreased | 83.27 | 44.20 | 4 | 138808 | 57509 | 79548067 |
Gait inability | 82.66 | 44.20 | 258 | 138554 | 58659 | 79546917 |
Orthostatic hypotension | 81.01 | 44.20 | 4 | 138808 | 56160 | 79549416 |
Pneumonitis | 79.96 | 44.20 | 7 | 138805 | 60853 | 79544723 |
Inflammation | 79.60 | 44.20 | 349 | 138463 | 93404 | 79512172 |
Staphylococcal infection | 78.54 | 44.20 | 6 | 138806 | 58289 | 79547287 |
Nerve injury | 78.18 | 44.20 | 89 | 138723 | 9303 | 79596273 |
Haematemesis | 77.77 | 44.20 | 3 | 138809 | 52261 | 79553315 |
Aspartate aminotransferase increased | 76.47 | 44.20 | 77 | 138735 | 138564 | 79467012 |
Aggression | 75.57 | 44.20 | 3 | 138809 | 50955 | 79554621 |
Arrhythmia | 75.44 | 44.20 | 9 | 138803 | 61263 | 79544313 |
Feeling abnormal | 75.31 | 44.20 | 100 | 138712 | 159099 | 79446477 |
Blepharospasm | 75.13 | 44.20 | 70 | 138742 | 5781 | 79599795 |
Jaundice | 73.28 | 44.20 | 5 | 138807 | 53344 | 79552232 |
Urinary retention | 73.09 | 44.20 | 7 | 138805 | 56623 | 79548953 |
Haemorrhage | 72.30 | 44.20 | 34 | 138778 | 91084 | 79514492 |
Transient ischaemic attack | 72.21 | 44.20 | 5 | 138807 | 52690 | 79552886 |
Haemoptysis | 72.07 | 44.20 | 7 | 138805 | 55992 | 79549584 |
Erythema | 71.83 | 44.20 | 178 | 138634 | 223112 | 79382464 |
Obesity | 71.27 | 44.20 | 176 | 138636 | 34949 | 79570627 |
Chills | 70.48 | 44.20 | 106 | 138706 | 160128 | 79445448 |
Dysarthria | 69.82 | 44.20 | 16 | 138796 | 67606 | 79537970 |
Sleep disorder | 69.76 | 44.20 | 315 | 138497 | 85362 | 79520214 |
C-reactive protein | 68.67 | 44.20 | 62 | 138750 | 4917 | 79600659 |
Neoplasm progression | 67.74 | 44.20 | 6 | 138806 | 51676 | 79553900 |
Asthenia | 67.54 | 44.20 | 568 | 138244 | 511121 | 79094455 |
Leukopenia | 67.41 | 44.20 | 62 | 138750 | 116451 | 79489125 |
Confusional state | 67.14 | 44.20 | 847 | 137965 | 317150 | 79288426 |
Injection site erythema | 67.12 | 44.20 | 26 | 138786 | 78171 | 79527405 |
Lethargy | 66.59 | 44.20 | 29 | 138783 | 81263 | 79524313 |
Dysgeusia | 66.58 | 44.20 | 10 | 138802 | 57167 | 79548409 |
Disturbance in attention | 66.31 | 44.20 | 6 | 138806 | 50795 | 79554781 |
Blood glucose increased | 65.55 | 44.20 | 62 | 138750 | 114913 | 79490663 |
Wound infection | 65.19 | 44.20 | 135 | 138677 | 23856 | 79581720 |
Joint ankylosis | 65.19 | 44.20 | 43 | 138769 | 2137 | 79603439 |
Respiratory tract congestion | 63.53 | 44.20 | 120 | 138692 | 19834 | 79585742 |
Lupus-like syndrome | 63.53 | 44.20 | 98 | 138714 | 13759 | 79591817 |
Blood pressure decreased | 62.35 | 44.20 | 49 | 138763 | 99417 | 79506159 |
Swelling face | 62.25 | 44.20 | 23 | 138789 | 71189 | 79534387 |
Product prescribing error | 62.14 | 44.20 | 4 | 138808 | 44809 | 79560767 |
Blood potassium decreased | 62.06 | 44.20 | 5 | 138807 | 46507 | 79559069 |
Tinnitus | 61.35 | 44.20 | 4 | 138808 | 44329 | 79561247 |
Angioedema | 60.90 | 44.20 | 28 | 138784 | 76007 | 79529569 |
Eosinophilia | 60.16 | 44.20 | 5 | 138807 | 45340 | 79560236 |
Shock | 60.06 | 44.20 | 4 | 138808 | 43544 | 79562032 |
Unevaluable event | 59.74 | 44.20 | 12 | 138800 | 55573 | 79550003 |
Drug ineffective for unapproved indication | 59.57 | 44.20 | 9 | 138803 | 51229 | 79554347 |
Multiple sclerosis relapse | 59.41 | 44.20 | 6 | 138806 | 46527 | 79559049 |
Alanine aminotransferase increased | 59.28 | 44.20 | 121 | 138691 | 162449 | 79443127 |
Dyskinesia | 59.22 | 44.20 | 5 | 138807 | 44768 | 79560808 |
Abdominal pain | 59.10 | 44.20 | 416 | 138396 | 389153 | 79216423 |
Hunger | 58.53 | 44.20 | 59 | 138753 | 5369 | 79600207 |
Blood alkaline phosphatase increased | 58.35 | 44.20 | 19 | 138793 | 63645 | 79541931 |
Angina pectoris | 58.10 | 44.20 | 10 | 138802 | 51722 | 79553854 |
Emotional distress | 57.16 | 44.20 | 3 | 138809 | 39966 | 79565610 |
Night sweats | 57.08 | 44.20 | 210 | 138602 | 51885 | 79553691 |
Lupus vulgaris | 56.97 | 44.20 | 47 | 138765 | 3299 | 79602277 |
Rash pruritic | 56.41 | 44.20 | 27 | 138785 | 71602 | 79533974 |
Cardiac disorder | 56.21 | 44.20 | 22 | 138790 | 65735 | 79539841 |
Pruritus | 56.16 | 44.20 | 982 | 137830 | 393666 | 79211910 |
Fluid retention | 55.46 | 44.20 | 26 | 138786 | 69783 | 79535793 |
Dizziness | 55.25 | 44.20 | 618 | 138194 | 525823 | 79079753 |
Liver disorder | 54.35 | 44.20 | 260 | 138552 | 72157 | 79533419 |
Seronegative arthritis | 54.29 | 44.20 | 53 | 138759 | 4639 | 79600937 |
Lymphadenopathy | 54.18 | 44.20 | 13 | 138799 | 53234 | 79552342 |
Injection site pain | 54.14 | 44.20 | 89 | 138723 | 129749 | 79475827 |
Laryngitis | 52.99 | 44.20 | 98 | 138714 | 15941 | 79589635 |
Lip swelling | 52.95 | 44.20 | 5 | 138807 | 40906 | 79564670 |
Head injury | 52.83 | 44.20 | 3 | 138809 | 37366 | 79568210 |
Bunion operation | 52.82 | 44.20 | 28 | 138784 | 924 | 79604652 |
Hypophagia | 52.67 | 44.20 | 8 | 138804 | 45359 | 79560217 |
No adverse event | 52.54 | 44.20 | 3 | 138809 | 37189 | 79568387 |
Prescribed underdose | 51.75 | 44.20 | 140 | 138672 | 29374 | 79576202 |
Oedema | 51.66 | 44.20 | 371 | 138441 | 119209 | 79486367 |
Oxygen saturation decreased | 51.47 | 44.20 | 91 | 138721 | 128956 | 79476620 |
Abnormal behaviour | 51.26 | 44.20 | 3 | 138809 | 36418 | 79569158 |
Anaphylactic reaction | 50.31 | 44.20 | 43 | 138769 | 83700 | 79521876 |
Cellulitis | 50.06 | 44.20 | 70 | 138742 | 108990 | 79496586 |
Pancreatitis | 49.37 | 44.20 | 29 | 138783 | 68546 | 79537030 |
Gamma-glutamyltransferase increased | 48.92 | 44.20 | 17 | 138795 | 54663 | 79550913 |
Presyncope | 48.22 | 44.20 | 7 | 138805 | 41047 | 79564529 |
Restlessness | 47.99 | 44.20 | 11 | 138801 | 46481 | 79559095 |
Pulmonary fibrosis | 47.64 | 44.20 | 177 | 138635 | 43935 | 79561641 |
Mesenteritis | 46.76 | 44.20 | 19 | 138793 | 335 | 79605241 |
Pneumonia viral | 46.59 | 44.20 | 68 | 138744 | 9090 | 79596486 |
Urinary incontinence | 45.74 | 44.20 | 8 | 138804 | 40901 | 79564675 |
Bacteraemia | 45.31 | 44.20 | 3 | 138809 | 32821 | 79572755 |
Depressed mood | 45.26 | 44.20 | 14 | 138798 | 48466 | 79557110 |
Circulatory collapse | 45.23 | 44.20 | 6 | 138806 | 37662 | 79567914 |
Skin ulcer | 44.85 | 44.20 | 19 | 138793 | 54131 | 79551445 |
Rectal haemorrhage | 44.84 | 44.20 | 40 | 138772 | 76260 | 79529316 |
None
Source | Code | Description |
---|---|---|
ATC | D07AC03 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, potent (group III) |
ATC | D07XC02 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, OTHER COMBINATIONS Corticosteroids, potent, other combinations |
FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
FDA EPC | N0000175576 | Corticosteroid |
MeSH PA | D000893 | Anti-Inflammatory Agents |
MeSH PA | D005938 | Glucocorticoids |
MeSH PA | D006728 | Hormones |
CHEBI has role | CHEBI:35472 | anti-inflammatory drugs |
CHEBI has role | CHEBI:59683 | antipruritic drugs |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Atopic dermatitis | indication | 24079001 | DOID:3310 |
Contact dermatitis | indication | 40275004 | DOID:2773 |
Seborrheic dermatitis | indication | 50563003 | DOID:8741 |
Lichen simplex chronicus | indication | 53891004 | |
Granuloma annulare | indication | 65508009 | DOID:3777 |
Pruritus ani | indication | 90446007 | |
Discoid lupus erythematosus | indication | 200938002 | |
Plaque psoriasis | indication | 200965009 | |
Scalp psoriasis | indication | 238608008 | |
Pruritus of genital organs | indication | 267802000 | |
Eruption of skin | indication | 271807003 | DOID:0050486 |
Primary cutaneous T-cell lymphoma | indication | 400122007 | |
Hypopituitarism | contraindication | 74728003 | DOID:9406 |
Atrophoderma | contraindication | 399979006 | |
Peripheral vascular disease | contraindication | 400047006 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 11.54 | acidic |
pKa2 | 12.99 | acidic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
0.25% | TOPICORT | TARO PHARMS | N204141 | April 11, 2013 | RX | SPRAY | TOPICAL | 8715624 | May 26, 2026 | TREATMENT OF PLAQUE PSORIASIS IN PATIENTS 18 YEARS OF AGE OR OLDER |
0.25% | TOPICORT | TARO PHARMS | N204141 | April 11, 2013 | RX | SPRAY | TOPICAL | 8277780 | Sept. 1, 2028 | TREATMENT OF PLAQUE PSORIASIS IN PATIENTS 18 YEARS OF AGE OR OLDER |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | Ki | 8.93 | DRUG MATRIX | CHEMBL | |||
Annexin A1 | Cytosolic other | WOMBAT-PK | |||||||
Progesterone receptor | Transcription factor | Ki | 7.96 | DRUG MATRIX |
ID | Source |
---|---|
4018465 | VUID |
N0000146789 | NUI |
D03697 | KEGG_DRUG |
3255 | RXNORM |
4018465 | VANDF |
C0011707 | UMLSCUI |
CHEBI:691037 | CHEBI |
CHEMBL1766 | ChEMBL_ID |
DB00547 | DRUGBANK_ID |
D003899 | MESH_DESCRIPTOR_UI |
5311067 | PUBCHEM_CID |
7067 | IUPHAR_LIGAND_ID |
2467 | INN_ID |
4E07GXB7AU | UNII |
1103 | MMSL |
4551 | MMSL |
002180 | NDDF |
387473009 | SNOMEDCT_US |
81457006 | SNOMEDCT_US |
CHEMBL16829 | ChEMBL_ID |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Desoximetasone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0151 | OINTMENT | 2.50 mg | TOPICAL | ANDA | 20 sections |
Desoximetasone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0180 | CREAM | 2.50 mg | TOPICAL | ANDA | 19 sections |
Desoximetasone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0472-0478 | CREAM | 2.50 mg | TOPICAL | ANDA | 14 sections |
Desoximetasone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0472-0479 | OINTMENT | 2.50 mg | TOPICAL | ANDA | 14 sections |
Desoximetasone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0713-0657 | OINTMENT | 2.50 mg | TOPICAL | ANDA | 14 sections |
Desoximetasone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 40032-024 | OINTMENT | 2.50 mg | TOPICAL | ANDA | 11 sections |
Desoximetasone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42254-015 | CREAM | 2.50 mg | TOPICAL | ANDA | 23 sections |
Desoximetasone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45802-495 | CREAM | 2.50 mg | TOPICAL | ANDA | 22 sections |
Desoximetasone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45802-495 | CREAM | 2.50 mg | TOPICAL | ANDA | 22 sections |
desoximetasone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45802-496 | OINTMENT | 2.50 mg | TOPICAL | ANDA | 22 sections |
desoximetasone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45802-496 | OINTMENT | 2.50 mg | TOPICAL | ANDA | 22 sections |
desoximetasone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45802-807 | SPRAY | 2.50 mg | TOPICAL | ANDA | 26 sections |
Desoximetasone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-0597 | CREAM | 2.50 mg | TOPICAL | ANDA | 22 sections |
Desoximetasone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-3919 | CREAM | 2.50 mg | TOPICAL | ANDA | 14 sections |
Desoximetasone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-5571 | CREAM | 2.50 mg | TOPICAL | ANDA | 21 sections |
Desoximetasone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-5571 | CREAM | 2.50 mg | TOPICAL | ANDA | 21 sections |
Desoximetasone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-1261 | GEL | 0.50 mg | TOPICAL | ANDA | 22 sections |
Desoximetasone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-1262 | OINTMENT | 2.50 mg | TOPICAL | ANDA | 22 sections |
Desoximetasone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-1270 | CREAM | 2.50 mg | TOPICAL | ANDA | 22 sections |
Desoximetasone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-1271 | CREAM | 0.50 mg | TOPICAL | ANDA | 22 sections |
Desoximetasone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-1352 | OINTMENT | 0.50 mg | TOPICAL | NDA | 22 sections |
Desoximetasone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-1396 | SPRAY | 2.50 mg | TOPICAL | NDA authorized generic | 29 sections |
Topicort | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-5202 | GEL | 0.50 mg | TOPICAL | ANDA | 22 sections |
Topicort | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-5203 | OINTMENT | 2.50 mg | TOPICAL | ANDA | 22 sections |
Topicort | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-5204 | CREAM | 2.50 mg | TOPICAL | ANDA | 22 sections |
Topicort | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-5205 | CREAM | 0.50 mg | TOPICAL | ANDA | 22 sections |
Topicort | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-5263 | OINTMENT | 0.50 mg | TOPICAL | NDA | 22 sections |
Topicort | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-5281 | SPRAY | 2.50 mg | TOPICAL | NDA | 29 sections |
Desoximetasone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52565-030 | OINTMENT | 2.50 mg | TOPICAL | ANDA | 22 sections |
Desoximetasone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52565-045 | OINTMENT | 0.50 mg | TOPICAL | ANDA | 22 sections |