acetylsalicylic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
74 50-78-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • acetylsalisylic acid
  • aspirin
  • acetylsalicylic acid
  • aspirin sodium
  • aspirin magnesium
  • aspirin potassium
  • aspirin calcium
  • aspirin anhydride
  • aspirin lysine
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
  • Molecular weight: 180.16
  • Formula: C9H8O4
  • CLOGP: 1.09
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 63.60
  • ALOGS: -2.09
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1 tablet O
30 mg O
3 g O
1 g P
3 g R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1.40 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 370.22 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.22 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 12 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.68 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.26 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
April 12, 1950 FDA ENDO PHARMS
Jan. 1, 1898 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 1388.04 11.32 8422 867176 810911 48918615
Gastrointestinal haemorrhage 1015.71 11.32 3183 872415 70138 49659388
Myocardial infarction 844.62 11.32 3413 872185 85614 49643912
Cerebrovascular accident 599.72 11.32 3226 872372 91454 49638072
Acute myocardial infarction 569.53 11.32 1438 874160 27835 49701691
Coronary artery disease 524.72 11.32 1408 874190 28318 49701208
Labelled drug-drug interaction medication error 522.28 11.32 768 874830 9709 49719817
Toxicity to various agents 457.66 11.32 5653 869945 206846 49522680
Treatment failure 456.39 11.32 1070 874528 136567 49592959
Off label use 434.50 11.32 5697 869901 468729 49260797
Completed suicide 415.50 11.32 3789 871809 128100 49601426
Cardiac failure congestive 409.83 11.32 2682 872916 81700 49647826
Device expulsion 378.94 11.32 32 875566 28790 49700736
Alopecia 363.15 11.32 2614 872984 242433 49487093
Injection site pain 333.92 11.32 907 874691 110117 49619409
Aspirin-exacerbated respiratory disease 318.72 11.32 195 875403 679 49728847
Melaena 291.35 11.32 1075 874523 25789 49703737
Angina pectoris 289.10 11.32 1054 874544 25134 49704392
Systemic lupus erythematosus 263.84 11.32 1393 874205 139229 49590297
Pemphigus 263.12 11.32 1126 874472 119040 49610486
Exposure to toxic agent 258.67 11.32 318 875280 3340 49726186
Injection site erythema 243.11 11.32 589 875009 74347 49655179
Injection site reaction 242.68 11.32 305 875293 49727 49679799
Therapeutic product effect incomplete 236.92 11.32 801 874797 90714 49638812
Upper gastrointestinal haemorrhage 233.76 11.32 709 874889 15326 49714200
Transient ischaemic attack 226.23 11.32 1130 874468 31080 49698446
Acute hepatic failure 224.63 11.32 689 874909 14988 49714538
Product use issue 214.19 11.32 1609 873989 147866 49581660
Pain 212.64 11.32 8035 867563 570868 49158658
Drug intolerance 211.32 11.32 2600 872998 216504 49513022
Angina unstable 209.88 11.32 399 875199 6307 49723219
Malignant neoplasm progression 208.18 11.32 552 875046 67572 49661954
Metabolic acidosis 201.93 11.32 1256 874342 37569 49691957
Vascular stent thrombosis 192.83 11.32 145 875453 764 49728762
Abdominal discomfort 186.99 11.32 2850 872748 228791 49500735
Psoriatic arthropathy 186.05 11.32 330 875268 46702 49682824
Plasma cell myeloma 179.31 11.32 1039 874559 30283 49699243
Coronary arterial stent insertion 173.51 11.32 221 875377 2413 49727113
Cerebral haemorrhage 171.24 11.32 922 874676 26130 49703396
Rhabdomyolysis 171.18 11.32 1210 874388 37817 49691709
Contraindicated product administered 163.36 11.32 1717 873881 147241 49582285
Febrile neutropenia 161.85 11.32 1007 874591 96660 49632866
Glossodynia 160.81 11.32 1254 874344 114315 49615211
Lower gastrointestinal haemorrhage 158.61 11.32 361 875237 6518 49723008
Condition aggravated 156.48 11.32 3928 871670 293130 49436396
Syncope 150.40 11.32 2562 873036 100440 49629086
Hypotension 149.08 11.32 5222 870376 230247 49499279
Haematoma 148.76 11.32 971 874627 29539 49699987
Coagulopathy 146.77 11.32 658 874940 17286 49712240
Injection site pruritus 145.45 11.32 300 875298 40111 49689415
Atrial fibrillation 144.32 11.32 2519 873079 99226 49630300
Wrong technique in product usage process 139.47 11.32 492 875106 55018 49674508
Injection site swelling 138.10 11.32 325 875273 41448 49688078
Haematemesis 134.95 11.32 882 874716 26843 49702683
Coronary artery occlusion 133.98 11.32 357 875241 7146 49722380
Hypoglycaemia 130.75 11.32 1461 874137 52120 49677406
Suicidal ideation 127.37 11.32 509 875089 54876 49674650
Angioedema 124.39 11.32 1094 874504 36582 49692944
Coronary artery bypass 122.92 11.32 174 875424 2119 49727407
Disease progression 122.05 11.32 1065 874533 94801 49634725
Myocardial ischaemia 121.97 11.32 460 875138 11153 49718373
Hospitalisation 121.79 11.32 683 874915 67254 49662272
Loss of personal independence in daily activities 120.88 11.32 713 874885 69337 49660189
Chest pain 120.80 11.32 3958 871640 172924 49556602
Haemoglobin decreased 120.04 11.32 2966 872632 124250 49605276
Product use in unapproved indication 118.96 11.32 1355 874243 114464 49615062
Musculoskeletal stiffness 117.25 11.32 1542 874056 126939 49602587
Mucosal inflammation 115.37 11.32 335 875263 39807 49689719
Rectal haemorrhage 114.82 11.32 1095 874503 37463 49692063
Coronary artery stenosis 108.95 11.32 234 875364 4055 49725471
Anion gap 107.73 11.32 115 875483 1022 49728504
Confusional state 107.50 11.32 4082 871516 181846 49547680
Arthropathy 106.40 11.32 2007 873591 155899 49573627
Haematochezia 105.89 11.32 1106 874492 38776 49690750
Acute kidney injury 105.59 11.32 4891 870707 223167 49506359
Blood loss anaemia 104.98 11.32 345 875253 7794 49721732
C-reactive protein abnormal 103.89 11.32 202 875396 27607 49701919
Haemorrhage intracranial 102.89 11.32 456 875142 11918 49717608
Drug resistance 102.67 11.32 106 875492 18883 49710643
Thrombosis in device 102.23 11.32 176 875422 2565 49726961
Synovitis 102.20 11.32 1517 874081 122348 49607178
Neutropenia 100.51 11.32 1878 873720 146087 49583439
Fall 99.90 11.32 6900 868698 328032 49401494
Blood pressure fluctuation 99.66 11.32 1003 874595 34820 49694706
Gastric ulcer 97.80 11.32 668 874930 20637 49708889
Accidental exposure to product 97.44 11.32 155 875443 22902 49706624
Acute coronary syndrome 97.36 11.32 370 875228 9004 49720522
Product administration error 95.45 11.32 626 874972 19073 49710453
Intentional product misuse 93.80 11.32 1228 874370 45506 49684020
Hand deformity 93.08 11.32 1198 874400 99001 49630525
Anaemia 92.72 11.32 5296 870302 247160 49482366
Therapeutic response decreased 91.79 11.32 462 875136 46769 49682757
Bradycardia 91.65 11.32 1596 874002 62830 49666696
Drug hypersensitivity 90.74 11.32 3488 872110 247522 49482004
Duodenal ulcer 89.92 11.32 290 875308 6485 49723041
International normalised ratio increased 88.33 11.32 1138 874460 42014 49687512
No adverse event 87.46 11.32 293 875305 33285 49696241
Medication error 86.96 11.32 982 874616 35122 49694404
Arthralgia 84.98 11.32 6488 869110 432214 49297312
Device dislocation 84.46 11.32 152 875446 21394 49708132
Overdose 82.97 11.32 2287 873311 97440 49632086
Product dose omission issue 82.15 11.32 2487 873111 181351 49548175
Device difficult to use 80.53 11.32 35 875563 9851 49719675
Vascular pseudoaneurysm 80.14 11.32 109 875489 1275 49728251
Device issue 79.10 11.32 140 875458 19832 49709694
Abortion spontaneous 78.69 11.32 413 875185 41359 49688167
Rheumatoid nodule 78.48 11.32 63 875535 12672 49716854
Neoplasm progression 78.31 11.32 251 875347 28906 49700620
Granuloma skin 77.75 11.32 6 875592 5812 49723714
Vascular stent stenosis 77.65 11.32 67 875531 443 49729083
Subdural haematoma 77.06 11.32 434 875164 12513 49717013
Psoriasis 76.93 11.32 792 874806 68208 49661318
Cytomegalovirus infection 76.62 11.32 120 875478 17842 49711684
Deafness transitory 75.93 11.32 122 875476 1674 49727852
Carotid artery stenosis 75.45 11.32 216 875382 4515 49725011
Haemorrhage 74.26 11.32 1319 874279 52122 49677404
Myelosuppression 71.35 11.32 77 875521 13440 49716086
Diverticulum intestinal haemorrhagic 71.14 11.32 96 875502 1114 49728412
Premature delivery 70.44 11.32 672 874926 22991 49706535
Pregnancy 70.43 11.32 268 875330 29309 49700217
Full blood count decreased 69.22 11.32 640 874958 21706 49707820
Retroperitoneal haemorrhage 69.05 11.32 143 875455 2413 49727113
Gastric ulcer haemorrhage 68.89 11.32 202 875396 4282 49725244
Palmar-plantar erythrodysaesthesia syndrome 68.33 11.32 154 875444 19944 49709582
Blood pressure increased 68.31 11.32 2886 872712 130246 49599280
Coronary artery thrombosis 67.89 11.32 88 875510 979 49728547
Therapy non-responder 67.07 11.32 562 875036 50460 49679066
Metastases to bone 66.97 11.32 131 875467 17864 49711662
Unintentional medical device removal 66.33 11.32 8 875590 5427 49724099
Asthenia 66.06 11.32 6393 869205 312649 49416877
Metastases to liver 65.97 11.32 157 875441 19947 49709579
Pericardial haemorrhage 65.73 11.32 102 875496 1356 49728170
Gastritis erosive 65.66 11.32 217 875381 4917 49724609
Cerebral infarction 65.54 11.32 616 874982 20988 49708538
Drug abuse 64.25 11.32 693 874905 59153 49670373
Thrombosis 63.61 11.32 1337 874261 54496 49675030
Muscle injury 63.50 11.32 948 874650 36163 49693363
Epistaxis 62.96 11.32 1500 874098 62454 49667072
Infective pulmonary exacerbation of cystic fibrosis 62.86 11.32 29 875569 7880 49721646
Haematotoxicity 62.67 11.32 29 875569 7866 49721660
Bone marrow failure 62.16 11.32 256 875342 27368 49702158
Intentional self-injury 62.04 11.32 199 875399 22913 49706613
Analgesic drug level increased 61.76 11.32 109 875489 1622 49727904
Neurotoxicity 61.43 11.32 100 875498 14640 49714886
Arteriosclerosis coronary artery 60.94 11.32 278 875320 7358 49722168
Internal haemorrhage 60.38 11.32 191 875407 4226 49725300
Retroperitoneal haematoma 60.15 11.32 138 875460 2505 49727021
Injection site warmth 59.75 11.32 92 875506 13774 49715752
Heart rate decreased 59.62 11.32 925 874673 35572 49693954
Duodenal ulcer haemorrhage 59.48 11.32 122 875476 2044 49727482
Haemorrhagic transformation stroke 59.22 11.32 84 875514 1025 49728501
Panniculitis 59.06 11.32 37 875561 8466 49721060
Haemorrhagic stroke 59.03 11.32 212 875386 5016 49724510
Ischaemic stroke 58.41 11.32 474 875124 15474 49714052
Blood parathyroid hormone decreased 58.25 11.32 25 875573 7089 49722437
Subarachnoid haemorrhage 58.15 11.32 352 875246 10424 49719102
Arteriosclerosis 57.86 11.32 310 875288 8767 49720759
Carotid artery thrombosis 56.89 11.32 97 875501 1402 49728124
Injection site rash 56.61 11.32 122 875476 16055 49713471
Neurologic neglect syndrome 56.20 11.32 95 875503 1363 49728163
Maternal exposure during pregnancy 55.98 11.32 2228 873370 157550 49571976
Spinal epidural haematoma 55.92 11.32 77 875521 912 49728614
Therapy interrupted 55.86 11.32 171 875427 19981 49709545
Hemiparesis 55.60 11.32 561 875037 19487 49710039
Seizure 55.52 11.32 1583 874015 116291 49613235
Swelling 55.38 11.32 2875 872723 197997 49531529
Migraine 55.34 11.32 942 874656 74338 49655188
Folliculitis 55.16 11.32 970 874628 38255 49691271
Uterine perforation 55.04 11.32 21 875577 6394 49723132
Neuroleptic malignant syndrome 54.85 11.32 67 875531 11063 49718463
Hemiplegia 54.71 11.32 263 875335 7118 49722408
Drug interaction 54.65 11.32 4085 871513 195536 49533990
Surgery 54.48 11.32 303 875295 29902 49699624
Multiple sclerosis relapse 54.34 11.32 478 875120 42486 49687040
Shock haemorrhagic 53.89 11.32 286 875312 8058 49721468
Mood swings 53.63 11.32 123 875475 15831 49713695
Lacunar infarction 53.23 11.32 145 875453 2942 49726584
Orthostatic hypotension 53.16 11.32 760 874838 28721 49700805
Leukopenia 52.94 11.32 835 874763 66693 49662833
Extradural haematoma 52.88 11.32 97 875501 1490 49728036
Hypertensive emergency 52.67 11.32 96 875502 1467 49728059
Pneumocystis jirovecii pneumonia 52.63 11.32 109 875489 14554 49714972
Sinusitis 52.34 11.32 3523 872075 167035 49562491
Fear of injection 52.32 11.32 20 875578 6083 49723443
Wound 51.81 11.32 1413 874185 104381 49625145
Sinus bradycardia 51.67 11.32 398 875200 12785 49716741
Mitral valve incompetence 50.94 11.32 494 875104 16977 49712549
Device use error 50.90 11.32 14 875584 5252 49724274
Coronary artery restenosis 50.54 11.32 45 875553 312 49729214
Febrile bone marrow aplasia 50.38 11.32 23 875575 6288 49723238
Transplant dysfunction 50.12 11.32 10 875588 4674 49724852
Complication of device insertion 49.83 11.32 21 875577 6020 49723506
Device malfunction 49.69 11.32 118 875480 15003 49714523
Product quality issue 49.62 11.32 321 875277 30537 49698989
Haemorrhagic arteriovenous malformation 49.45 11.32 31 875567 114 49729412
Epstein-Barr virus infection 49.22 11.32 30 875568 6967 49722559
Injection site urticaria 48.96 11.32 85 875513 12132 49717394
Joint stiffness 48.88 11.32 315 875283 29993 49699533
Hyponatraemia 48.60 11.32 2081 873517 94058 49635468
Acute myeloid leukaemia 47.67 11.32 120 875478 14954 49714572
Rash 47.12 11.32 6744 868854 430727 49298799
Haemophagocytic lymphohistiocytosis 46.89 11.32 48 875550 8585 49720941
Arthritis 46.51 11.32 1143 874455 85578 49643948
Post procedural haematoma 46.37 11.32 79 875519 1141 49728385
Knee arthroplasty 46.13 11.32 397 875201 35449 49694077
Irritable bowel syndrome 45.42 11.32 1189 874409 50252 49679274
Interstitial lung disease 45.31 11.32 647 874951 52529 49676997
Faeces discoloured 44.62 11.32 451 875147 15673 49713853
Unintended pregnancy 44.46 11.32 15 875583 4931 49724595
Exposure during pregnancy 44.22 11.32 1679 873919 119336 49610190
Lactic acidosis 44.13 11.32 817 874781 32538 49696988
Vascular graft 43.56 11.32 60 875538 711 49728815
Abdominal wall haematoma 43.54 11.32 124 875474 2584 49726942
Acute graft versus host disease 43.31 11.32 8 875590 3950 49725576
Metastases to lung 42.96 11.32 78 875520 10942 49718584
Ascites 42.73 11.32 405 875193 35456 49694070
Ankylosing spondylitis 42.24 11.32 37 875561 7128 49722398
Drug withdrawal syndrome 41.82 11.32 258 875340 24823 49704703
Pancytopenia 41.48 11.32 1121 874477 82909 49646617
Haematuria 41.39 11.32 648 874950 24965 49704561
Posterior reversible encephalopathy syndrome 41.14 11.32 127 875471 14801 49714725
Contusion 40.82 11.32 2352 873246 109831 49619695
Gastrointestinal toxicity 40.65 11.32 15 875583 4662 49724864
Metastases to lymph nodes 40.53 11.32 37 875561 6987 49722539
Heart rate irregular 40.22 11.32 512 875086 18848 49710678
Graft versus host disease 39.92 11.32 29 875569 6137 49723389
Amenorrhoea 39.81 11.32 53 875545 8431 49721095
Intraventricular haemorrhage 39.68 11.32 95 875503 1775 49727751
Hepatotoxicity 39.61 11.32 677 874921 26549 49702977
Post procedural haemorrhage 39.56 11.32 238 875360 7032 49722494
Product prescribing error 39.25 11.32 544 875054 20417 49709109
Depressed level of consciousness 39.20 11.32 1177 874421 50776 49678750
Gastrointestinal vascular malformation haemorrhagic 39.11 11.32 29 875569 149 49729377
Presyncope 39.03 11.32 612 874986 23586 49705940
Constipation 38.75 11.32 3724 871874 181984 49547542
Hip arthroplasty 38.72 11.32 338 875260 30091 49699435
Chronic graft versus host disease 38.19 11.32 3 875595 2864 49726662
Product storage error 38.12 11.32 98 875500 12126 49717400
Muscle spasticity 38.08 11.32 460 875138 16724 49712802
Ischaemia 37.75 11.32 161 875437 4136 49725390
Product monitoring error 37.31 11.32 119 875479 2645 49726881
Abortion incomplete 37.18 11.32 5 875593 3121 49726405
Metastases to central nervous system 37.10 11.32 88 875510 11194 49718332
Dizziness 36.81 11.32 6667 868931 339702 49389824
Acute lung injury 36.54 11.32 77 875521 1316 49728210
Cardiac arrest 36.49 11.32 1784 873814 81867 49647659
Hyperkalaemia 36.43 11.32 1090 874508 46999 49682527
Adverse event 36.39 11.32 535 875063 43228 49686298
Peripheral arterial occlusive disease 36.23 11.32 139 875459 3398 49726128
Ecchymosis 36.03 11.32 300 875298 9869 49719657
Adjustment disorder 35.98 11.32 96 875502 1923 49727603
Subdural haemorrhage 35.88 11.32 117 875481 2632 49726894
Peripheral ischaemia 35.87 11.32 158 875440 4118 49725408
Pregnancy with contraceptive device 35.59 11.32 13 875585 4066 49725460
Dystonia 35.39 11.32 98 875500 11828 49717698
Withdrawal syndrome 35.36 11.32 170 875428 17420 49712106
Pathogen resistance 35.24 11.32 28 875570 5661 49723865
Osteonecrosis of jaw 35.16 11.32 376 875222 32150 49697376
Creatinine renal clearance decreased 35.16 11.32 337 875261 11544 49717982
Stent placement 35.13 11.32 135 875463 3303 49726223
Injection site bruising 35.09 11.32 437 875161 36331 49693195
Sinus node dysfunction 34.60 11.32 148 875450 3807 49725719
Foot deformity 34.48 11.32 193 875405 19017 49710509
Hyperprolactinaemia 34.35 11.32 8 875590 3357 49726169
Fibromyalgia 34.30 11.32 559 875039 44419 49685107
Asthma 34.08 11.32 1233 874365 88104 49641422
Skin necrosis 33.98 11.32 87 875511 10780 49718746
Pyroglutamate increased 33.80 11.32 39 875559 381 49729145
Hepatic cirrhosis 33.54 11.32 173 875425 17404 49712122
C-reactive protein increased 33.54 11.32 884 874714 65590 49663936
Gastric haemorrhage 33.28 11.32 190 875408 5506 49724020
Graft versus host disease in skin 33.15 11.32 3 875595 2553 49726973
Red blood cell sedimentation rate increased 33.04 11.32 337 875261 29079 49700447
Drug ineffective for unapproved indication 32.89 11.32 224 875374 21057 49708469
Drug eruption 32.86 11.32 256 875342 23350 49706176
Device breakage 32.58 11.32 73 875525 9474 49720052
Atrioventricular block complete 32.42 11.32 226 875372 7029 49722497
Injection site mass 32.42 11.32 150 875448 15530 49713996
Haemoptysis 32.32 11.32 622 874976 24951 49704575
Akathisia 32.30 11.32 58 875540 8171 49721355
Mania 32.17 11.32 90 875508 10826 49718700
Intermittent claudication 31.86 11.32 81 875517 1574 49727952
Coronary artery aneurysm 31.78 11.32 14 875584 18 49729508
Arterial stenosis 31.72 11.32 44 875554 525 49729001
Multiple-drug resistance 31.68 11.32 9 875589 3305 49726221
Aspergillus infection 31.61 11.32 43 875555 6778 49722748
Myopathy 31.53 11.32 268 875330 8871 49720655
Prothrombin time prolonged 31.46 11.32 261 875337 8577 49720949
Blood creatine phosphokinase increased 31.20 11.32 635 874963 25732 49703794
Cardiac disorder 31.17 11.32 969 874629 42010 49687516
Cystic fibrosis 30.89 11.32 6 875592 2858 49726668
Blood pressure diastolic decreased 30.81 11.32 434 875164 16347 49713179
Immune reconstitution inflammatory syndrome 30.72 11.32 30 875568 5486 49724040
Depression 30.70 11.32 2454 873144 162969 49566557
Complication of device removal 30.50 11.32 17 875581 4147 49725379
Hepatic cytolysis 30.30 11.32 242 875356 7861 49721665
Bronchopulmonary aspergillosis 30.26 11.32 53 875545 7539 49721987
Intentional overdose 30.25 11.32 1347 874251 61157 49668369
Discomfort 30.25 11.32 1549 874049 106831 49622695
Coronary artery dissection 30.21 11.32 49 875549 678 49728848
Irritability 30.17 11.32 330 875268 28096 49701430
Spontaneous haematoma 30.01 11.32 51 875547 735 49728791
Breast cancer 29.82 11.32 542 875056 42348 49687178
Second primary malignancy 29.67 11.32 46 875552 6868 49722658
Mucormycosis 29.47 11.32 4 875594 2479 49727047
Rheumatoid arthritis 29.46 11.32 3061 872537 199489 49530037
Cytomegalovirus viraemia 29.39 11.32 23 875575 4686 49724840
Hepatic necrosis 29.32 11.32 173 875425 5075 49724451
Erythema 29.21 11.32 2159 873439 144255 49585271
Large intestinal haemorrhage 29.21 11.32 64 875534 1125 49728401
Anion gap abnormal 29.08 11.32 33 875565 316 49729210
Ischaemic cardiomyopathy 28.92 11.32 97 875501 2215 49727311
Pyroglutamic acidosis 28.91 11.32 37 875561 406 49729120
Cerebellar haemorrhage 28.81 11.32 66 875532 1197 49728329
Blood calcium decreased 28.73 11.32 511 875087 20195 49709331
Hypophagia 28.71 11.32 655 874943 27073 49702453
Pyrexia 28.68 11.32 5976 869622 374227 49355299
Spinal cord haemorrhage 28.59 11.32 26 875572 186 49729340
Oesophageal intramural haematoma 28.55 11.32 18 875580 67 49729459
Heparin-induced thrombocytopenia 28.47 11.32 140 875458 3825 49725701
Blood iron abnormal 28.35 11.32 11 875587 3315 49726211
Swollen tongue 28.32 11.32 672 874926 27958 49701568
Post transplant lymphoproliferative disorder 28.24 11.32 19 875579 4185 49725341
Atrioventricular block 27.90 11.32 200 875398 6278 49723248
Multiple injuries 27.89 11.32 78 875520 1608 49727918
Carotid artery occlusion 27.84 11.32 101 875497 2402 49727124
Thrombotic microangiopathy 27.78 11.32 70 875528 8721 49720805
Arterial haemorrhage 27.72 11.32 74 875524 1483 49728043
Galactorrhoea 27.56 11.32 15 875583 3708 49725818
Joint swelling 27.41 11.32 3772 871826 241514 49488012
Acute graft versus host disease in skin 27.40 11.32 9 875589 3009 49726517
Colitis microscopic 27.34 11.32 200 875398 6320 49723206
Puncture site haemorrhage 27.25 11.32 28 875570 237 49729289
Ovarian cyst 27.13 11.32 137 875461 13859 49715667
Carotid arteriosclerosis 27.03 11.32 55 875543 916 49728610
Transplant rejection 27.02 11.32 81 875517 9528 49719998
Human herpesvirus 6 infection 26.99 11.32 6 875592 2600 49726926
Complication associated with device 26.98 11.32 146 875452 14509 49715017
Oesophagitis haemorrhagic 26.98 11.32 34 875564 367 49729159
Blood creatinine increased 26.97 11.32 1593 874005 74567 49654959
Chronic obstructive pulmonary disease 26.84 11.32 1156 874442 52279 49677247
Peripheral artery stenosis 26.68 11.32 39 875559 490 49729036
Sinus arrest 26.57 11.32 77 875521 1621 49727905
Paradoxical drug reaction 26.55 11.32 15 875583 3632 49725894
Disability 26.54 11.32 122 875476 12653 49716873
Body temperature increased 26.40 11.32 720 874878 30621 49698905
Acidosis 26.38 11.32 282 875316 9945 49719581
Venoocclusive liver disease 26.36 11.32 21 875577 4240 49725286
Blood urea increased 26.28 11.32 563 875035 23022 49706504
Ventricular fibrillation 26.24 11.32 289 875309 10270 49719256
Pharyngeal haemorrhage 26.24 11.32 39 875559 498 49729028
Enthesopathy 26.22 11.32 53 875545 7140 49722386
Joint destruction 25.90 11.32 18 875580 3898 49725628
Aortic stenosis 25.90 11.32 142 875456 4052 49725474
Personality disorder 25.77 11.32 145 875453 4179 49725347
Injection site induration 25.67 11.32 68 875530 8329 49721197
Grip strength decreased 25.63 11.32 115 875483 12006 49717520
Urogenital haemorrhage 25.49 11.32 26 875572 218 49729308
Blood prolactin increased 25.20 11.32 11 875587 3088 49726438
Arthrodesis 25.18 11.32 6 875592 2479 49727047
Infection 25.10 11.32 2614 872984 170340 49559186
Ventricular hypertrophy 24.88 11.32 116 875482 3099 49726427
Drug dose omission by device 24.59 11.32 8 875590 2691 49726835
Device deployment issue 24.58 11.32 15 875583 3481 49726045
Anion gap increased 24.45 11.32 69 875529 1430 49728096
Troponin increased 24.39 11.32 231 875367 7887 49721639
Inflammation 24.38 11.32 774 874824 56138 49673388
Accidental overdose 24.31 11.32 474 875124 19059 49710467
Peripheral vascular disorder 24.25 11.32 170 875428 5297 49724229
Therapeutic product effect decreased 24.21 11.32 2025 873573 134025 49595501
Cardiogenic shock 24.21 11.32 392 875206 15207 49714319
Sleep disorder due to general medical condition, insomnia type 24.14 11.32 714 874884 30733 49698793
Hepatic ischaemia 24.09 11.32 40 875558 565 49728961
Drug dependence 24.03 11.32 222 875376 19537 49709989
Graft versus host disease in gastrointestinal tract 24.03 11.32 9 875589 2772 49726754
Sepsis 24.03 11.32 1976 873622 130949 49598577
Gestational diabetes 23.94 11.32 59 875539 7406 49722120
Diverticulitis intestinal haemorrhagic 23.92 11.32 19 875579 110 49729416
Hypertension 23.65 11.32 4077 871521 207126 49522400
Blood pressure systolic increased 23.57 11.32 791 874807 34658 49694868
Brain herniation 23.52 11.32 111 875487 2981 49726545
Abortion early 23.51 11.32 10 875588 11 49729515
Small intestinal haemorrhage 23.46 11.32 80 875518 1843 49727683
Incorrect route of product administration 23.45 11.32 208 875390 18458 49711068
Arterial occlusive disease 23.42 11.32 153 875445 4655 49724871
Status epilepticus 23.35 11.32 136 875462 13270 49716256
Sexual dysfunction 23.32 11.32 14 875584 3278 49726248
Adenovirus infection 23.11 11.32 13 875585 3155 49726371
Device related infection 23.10 11.32 238 875360 20497 49709029
Tenosynovitis 23.09 11.32 99 875499 10466 49719060
Pallor 23.09 11.32 545 875053 22654 49706872
Tricuspid valve incompetence 22.94 11.32 329 875269 12441 49717085
Pulmonary tuberculosis 22.93 11.32 24 875574 4249 49725277
Lower respiratory tract infection 22.88 11.32 1929 873669 93272 49636254
Therapy partial responder 22.82 11.32 50 875548 6541 49722985
Occult blood positive 22.78 11.32 115 875483 3176 49726350
Sickle cell anaemia with crisis 22.76 11.32 27 875571 4516 49725010
Product substitution issue 22.71 11.32 146 875452 13911 49715615
Atrioventricular block second degree 22.63 11.32 123 875475 3498 49726028
Myoglobin blood increased 22.56 11.32 61 875537 1232 49728294
Thalamus haemorrhage 22.53 11.32 39 875559 571 49728955
Oesophageal haemorrhage 22.50 11.32 36 875562 492 49729034
Drug tolerance 22.43 11.32 32 875566 4944 49724582
Blister 22.34 11.32 1742 873856 83676 49645850
Traumatic haemorrhage 22.34 11.32 34 875564 444 49729082
Coordination abnormal 22.27 11.32 301 875297 11233 49718293
Lung disorder 22.27 11.32 597 875001 44202 49685324
Blood pressure decreased 22.25 11.32 1182 874416 54727 49674799
Microcytic anaemia 22.22 11.32 109 875489 2975 49726551
Lymphoproliferative disorder 22.17 11.32 11 875587 2866 49726660
Gastrointestinal pain 22.13 11.32 225 875373 7831 49721695
Cerebral haematoma 22.08 11.32 112 875486 3099 49726427
Labile blood pressure 21.98 11.32 71 875527 1589 49727937
Infusion site swelling 21.96 11.32 205 875393 6971 49722555
Sedation complication 21.82 11.32 240 875358 8526 49721000
Acne 21.80 11.32 225 875373 19370 49710156
Basal cell carcinoma 21.76 11.32 279 875319 23077 49706449
Device leakage 21.69 11.32 43 875555 5835 49723691
Renal artery stenosis 21.68 11.32 71 875527 1601 49727925
Embedded device 21.64 11.32 11 875587 2826 49726700
Metastases to peritoneum 21.58 11.32 11 875587 2822 49726704
Traumatic intracranial haemorrhage 21.39 11.32 30 875568 362 49729164
Anaphylactic shock 21.38 11.32 234 875364 19921 49709605
Bleeding time prolonged 21.37 11.32 38 875560 569 49728957
Diverticulum 21.33 11.32 279 875319 10335 49719191
Labile hypertension 21.30 11.32 33 875565 438 49729088
Coronary angioplasty 21.18 11.32 16 875582 85 49729441
Septic shock 21.15 11.32 792 874806 56383 49673143
Tuberculosis 21.12 11.32 96 875502 9987 49719539
Neoplasm malignant 21.10 11.32 286 875312 23429 49706097
Dilatation atrial 21.08 11.32 75 875523 1766 49727760
Blood creatine phosphokinase MB increased 21.06 11.32 55 875543 1087 49728439
Blood glucose decreased 21.03 11.32 437 875161 17774 49711752
Osteoarthritis 21.00 11.32 971 874627 67635 49661891
Abdominal pain upper 20.88 11.32 3102 872496 156207 49573319
Haemorrhagic erosive gastritis 20.73 11.32 25 875573 257 49729269
Lymphadenopathy 20.65 11.32 432 875166 33067 49696459
Liver function test increased 20.61 11.32 315 875283 25291 49704235
Osteoporosis 20.53 11.32 605 874993 44274 49685252
Implant site pain 20.53 11.32 6 875592 2163 49727363
Genital haemorrhage 20.27 11.32 53 875545 6521 49723005
Normochromic normocytic anaemia 20.23 11.32 132 875466 4014 49725512
Ill-defined disorder 20.08 11.32 1147 874451 53507 49676019
Ear infection 20.03 11.32 590 875008 25380 49704146
Urine abnormality 20.00 11.32 180 875418 6058 49723468
Foetal exposure timing unspecified 19.98 11.32 21 875577 183 49729343
Cerebrovascular disorder 19.94 11.32 93 875505 2485 49727041
Balance disorder 19.86 11.32 1448 874150 69142 49660384
Dactylitis 19.86 11.32 4 875594 1857 49727669
Oesophageal mucosal dissection 19.85 11.32 9 875589 13 49729513
HELLP syndrome 19.84 11.32 47 875551 872 49728654
Dehydration 19.81 11.32 2967 872631 149482 49580044
Cerebral ischaemia 19.72 11.32 172 875426 5736 49723790
Red blood cell sedimentation rate abnormal 19.71 11.32 184 875414 16159 49713367
Haematocrit decreased 19.71 11.32 766 874832 34210 49695316
Anosognosia 19.69 11.32 7 875591 2227 49727299
Menstruation irregular 19.53 11.32 49 875549 6113 49723413
Pulmonary renal syndrome 19.47 11.32 29 875569 371 49729155
Headache 19.44 11.32 8190 867408 498345 49231181
Cataract 19.43 11.32 1003 874595 46297 49683229
Blood glucose increased 19.38 11.32 1459 874139 69865 49659661
Underdose 19.35 11.32 241 875357 20037 49709489
Hepatitis B reactivation 19.34 11.32 6 875592 2081 49727445
Incorrect dose administered by device 19.24 11.32 19 875579 3456 49726070
Aortic valve stenosis 19.23 11.32 102 875496 2873 49726653
Hallucination, auditory 19.14 11.32 108 875490 10620 49718906
Pre-existing condition improved 19.12 11.32 61 875537 7036 49722490
Electrocardiogram ST segment elevation 19.09 11.32 114 875484 3359 49726167
Disease recurrence 19.03 11.32 239 875359 19842 49709684
Low birth weight baby 19.01 11.32 170 875428 5711 49723815
Catatonia 18.93 11.32 22 875576 3714 49725812
Hepatitis cholestatic 18.84 11.32 175 875423 5942 49723584
Hepatic failure 18.66 11.32 709 874889 31574 49697952
Hypothermia 18.66 11.32 302 875296 11714 49717812
Iliac artery stenosis 18.65 11.32 10 875588 25 49729501
Pulmonary toxicity 18.60 11.32 43 875555 5519 49724007
Electric shock 18.44 11.32 49 875549 979 49728547
Femoral artery aneurysm 18.43 11.32 7 875591 4 49729522
Bone density decreased 18.42 11.32 114 875484 10961 49718565
Dysphoria 18.42 11.32 34 875564 4740 49724786
Granuloma 18.39 11.32 35 875563 4823 49724703
Lupus-like syndrome 18.34 11.32 93 875505 9398 49720128
Haemothorax 18.32 11.32 75 875523 1891 49727635
Cardiac failure 18.31 11.32 1541 874057 74499 49655027
Hepatorenal syndrome 18.27 11.32 69 875529 1674 49727852
Multiple allergies 18.08 11.32 225 875373 8238 49721288
Therapy cessation 17.98 11.32 329 875269 25682 49703844
Product preparation error 17.90 11.32 30 875568 4342 49725184
Abortion induced 17.81 11.32 92 875506 9252 49720274
Head injury 17.80 11.32 543 875055 23477 49706049
Ischaemic cerebral infarction 17.77 11.32 52 875546 1101 49728425
Electrocardiogram ST segment depression 17.75 11.32 91 875507 2529 49726997
Acute lymphocytic leukaemia recurrent 17.74 11.32 6 875592 1969 49727557
Abnormal loss of weight 17.73 11.32 149 875449 4915 49724611
Ventricular tachycardia 17.73 11.32 378 875220 15443 49714083
Colitis ischaemic 17.71 11.32 246 875352 9237 49720289
Gastrointestinal angiodysplasia 17.69 11.32 28 875570 379 49729147
Hypochromic anaemia 17.66 11.32 67 875531 1629 49727897
Arterial injury 17.62 11.32 19 875579 171 49729355
Mood altered 17.55 11.32 139 875459 12634 49716892
Renal failure 17.42 11.32 2104 873494 104529 49624997
Gastrointestinal ulcer haemorrhage 17.39 11.32 35 875563 578 49728948
Drug specific antibody 17.36 11.32 5 875593 1820 49727706
Tendonitis 17.30 11.32 195 875403 16510 49713016
Device inappropriate shock delivery 17.29 11.32 7 875591 6 49729520
Cardiac tamponade 17.28 11.32 129 875469 4103 49725423
Activated partial thromboplastin time prolonged 17.20 11.32 178 875420 6224 49723302
Nonreassuring foetal heart rate pattern 17.17 11.32 10 875588 31 49729495
Dysmorphism 17.14 11.32 8 875590 2159 49727367
Gastritis 17.12 11.32 716 874882 32267 49697259
Nausea 17.11 11.32 11569 864029 693829 49035697
Cardiovascular disorder 17.09 11.32 265 875333 10189 49719337
Small intestinal ulcer haemorrhage 17.04 11.32 12 875586 56 49729470
Oral herpes 17.01 11.32 254 875344 20471 49709055
Oedema peripheral 16.99 11.32 3043 872555 154918 49574608
Tuberculin test positive 16.98 11.32 18 875580 3168 49726358
Atrioventricular block first degree 16.94 11.32 173 875425 6028 49723498
Infusion site pain 16.89 11.32 304 875294 12042 49717484
Muscle haemorrhage 16.84 11.32 98 875500 2860 49726666
Subcutaneous haematoma 16.74 11.32 61 875537 1454 49728072
Left ventricular hypertrophy 16.67 11.32 142 875456 4703 49724823
Brain contusion 16.65 11.32 32 875566 510 49729016
Bundle branch block left 16.64 11.32 173 875425 6057 49723469
Maternal exposure before pregnancy 16.60 11.32 46 875552 5551 49723975
Drug reaction with eosinophilia and systemic symptoms 16.52 11.32 370 875228 28054 49701472
Wheezing 16.51 11.32 891 874707 61156 49668370
Retinitis 16.49 11.32 6 875592 1881 49727645
Peptic ulcer 16.44 11.32 119 875479 3747 49725779
Ulcer haemorrhage 16.40 11.32 107 875491 3254 49726272
Cardiac valve disease 16.37 11.32 117 875481 3669 49725857
Impaired quality of life 16.35 11.32 52 875546 6004 49723522
Ectopic pregnancy 16.34 11.32 10 875588 2317 49727209
Product adhesion issue 16.32 11.32 32 875566 4360 49725166
Foetal growth restriction 16.29 11.32 181 875417 6446 49723080
Gastrointestinal disorder 16.26 11.32 1870 873728 92586 49636940
Laboratory test abnormal 16.23 11.32 521 875077 22687 49706839
Cognitive disorder 16.21 11.32 926 874672 43197 49686329
Carotid artery disease 16.19 11.32 61 875537 1478 49728048
Thinking abnormal 16.16 11.32 98 875500 9469 49720057
Metastasis 16.15 11.32 32 875566 4343 49725183
Infusion site erythema 16.14 11.32 226 875372 8501 49721025
Traumatic liver injury 16.13 11.32 22 875576 258 49729268
Hip fracture 16.08 11.32 574 875024 25357 49704169
Haemodialysis 16.06 11.32 218 875380 8144 49721382
PCO2 decreased 15.99 11.32 52 875546 1168 49728358
Crystal urine present 15.99 11.32 59 875539 1415 49728111
Mediastinal haematoma 15.89 11.32 13 875585 79 49729447
Subchorionic haematoma 15.81 11.32 15 875583 114 49729412
Deformity 15.80 11.32 77 875521 7863 49721663
Endometriosis 15.74 11.32 29 875569 4046 49725480
Varicella zoster virus infection 15.73 11.32 12 875586 2477 49727049
Wound haematoma 15.71 11.32 12 875586 65 49729461
Haemoglobin increased 15.71 11.32 100 875498 3015 49726511
Alanine aminotransferase abnormal 15.68 11.32 30 875568 4126 49725400
Blood pressure systolic abnormal 15.67 11.32 203 875395 7503 49722023
Foetal exposure during pregnancy 15.66 11.32 357 875241 27002 49702524
Adrenal insufficiency 15.66 11.32 164 875434 14079 49715447
Juvenile idiopathic arthritis 15.64 11.32 16 875582 2863 49726663
Rheumatoid factor positive 15.60 11.32 704 874894 49155 49680371
Blood pressure diastolic abnormal 15.57 11.32 238 875360 9123 49720403
Aortic valve incompetence 15.55 11.32 154 875444 5322 49724204
Nodule 15.51 11.32 204 875394 16799 49712727
Epilepsy 15.48 11.32 271 875327 21296 49708230
Injection site discolouration 15.46 11.32 65 875533 6909 49722617
Brain stem haemorrhage 15.40 11.32 37 875561 693 49728833
Cardiomegaly 15.38 11.32 373 875225 15572 49713954
Myalgia 15.38 11.32 2413 873185 121906 49607620
Pulmonary oedema 15.36 11.32 1013 874585 47925 49681601
Eating disorder 15.33 11.32 362 875236 15047 49714479
Procedural pain 15.31 11.32 159 875439 13673 49715853
Rash papulosquamous 15.29 11.32 13 875585 84 49729442
Aneurysm 15.25 11.32 84 875514 2401 49727125
Left-to-right cardiac shunt 15.23 11.32 15 875583 120 49729406
Dermatitis exfoliative generalised 15.21 11.32 19 875579 3107 49726419
Anxiety 15.20 11.32 2773 872825 174833 49554693
Platelet aggregation inhibition 15.14 11.32 15 875583 121 49729405
Basal ganglia haemorrhage 15.13 11.32 31 875567 519 49729007
Iron deficiency anaemia 15.12 11.32 390 875208 16444 49713082
Retinal haemorrhage 15.10 11.32 133 875465 4448 49725078
Respiratory rate increased 15.10 11.32 279 875319 11106 49718420
Intracranial aneurysm 15.09 11.32 103 875495 3181 49726345
Electrocardiogram T wave abnormal 15.08 11.32 78 875520 2175 49727351
Ductus arteriosus premature closure 14.97 11.32 23 875575 303 49729223
Bipolar disorder 14.96 11.32 63 875535 6694 49722832
Pelvic pain 14.96 11.32 123 875475 11090 49718436
Mental disorder 14.94 11.32 279 875319 21712 49707814
Haemorrhage urinary tract 14.87 11.32 38 875560 741 49728785
Paronychia 14.69 11.32 36 875562 4528 49724998
Functional gastrointestinal disorder 14.67 11.32 106 875492 3336 49726190
Mental status changes 14.66 11.32 768 874830 35504 49694022
Hypogammaglobulinaemia 14.65 11.32 50 875548 5649 49723877
Blood creatine increased 14.65 11.32 139 875459 4748 49724778
Joint laxity 14.61 11.32 12 875586 2386 49727140
Polyarthritis 14.58 11.32 79 875519 7848 49721678
Ventricular internal diameter abnormal 14.57 11.32 9 875589 32 49729494
Diverticulum intestinal 14.56 11.32 162 875436 5771 49723755
Pruritus 14.55 11.32 5288 870310 278280 49451246
Femur fracture 14.52 11.32 516 875082 36948 49692578
Bradyarrhythmia 14.48 11.32 68 875530 1822 49727704
Extremity necrosis 14.41 11.32 57 875541 1414 49728112
Infusion site pruritus 14.41 11.32 117 875481 3820 49725706
Vessel puncture site haematoma 14.41 11.32 14 875584 110 49729416
Lymphopenia 14.40 11.32 187 875411 15434 49714092
Osmolar gap 14.40 11.32 13 875585 92 49729434
Platelet aggregation increased 14.40 11.32 7 875591 13 49729513
Reye's syndrome 14.39 11.32 6 875592 6 49729520
Full blood count increased 14.38 11.32 41 875557 855 49728671
Rectourethral fistula 14.38 11.32 9 875589 33 49729493
Sleep disorder due to a general medical condition 14.37 11.32 72 875526 7299 49722227
Seasonal allergy 14.37 11.32 344 875254 14332 49715194
Platelet function test abnormal 14.30 11.32 12 875586 76 49729450
Potentiating drug interaction 14.29 11.32 114 875484 3702 49725824
Blood potassium decreased 14.28 11.32 779 874819 36166 49693360
Infusion site extravasation 14.28 11.32 184 875414 6792 49722734
Angioplasty 14.26 11.32 51 875547 1204 49728322
Body height decreased 14.25 11.32 225 875373 8683 49720843
Cardiac murmur 14.21 11.32 264 875334 10520 49719006
Aortic arteriosclerosis 14.16 11.32 149 875449 5233 49724293
Dysarthria 14.13 11.32 787 874811 36616 49692910
Haemoperitoneum 14.13 11.32 84 875514 2471 49727055
Idiopathic intracranial hypertension 14.01 11.32 12 875586 2337 49727189
Dementia 13.90 11.32 369 875229 15628 49713898
Pharyngitis 13.87 11.32 399 875199 17104 49712422
Drug dispensed to wrong patient 13.87 11.32 17 875581 178 49729348
Hepatitis acute 13.86 11.32 204 875394 7757 49721769
Thrombotic stroke 13.85 11.32 28 875570 464 49729062
Troponin T increased 13.84 11.32 42 875556 908 49728618
Haemorrhage subcutaneous 13.80 11.32 87 875511 2614 49726912
Heart rate increased 13.79 11.32 1533 874065 75717 49653809
Mouth haemorrhage 13.79 11.32 166 875432 6030 49723496
Pregnancy with implant contraceptive 13.78 11.32 9 875589 2014 49727512
Therapeutic response unexpected 13.78 11.32 193 875405 15722 49713804
Diabetic retinopathy 13.76 11.32 75 875523 2135 49727391
Spinal subdural haematoma 13.76 11.32 14 875584 117 49729409
Muscle spasms 13.75 11.32 2421 873177 123132 49606394
Nasopharyngitis 13.75 11.32 3645 871953 189282 49540244
Essential thrombocythaemia 13.75 11.32 15 875583 137 49729389
Cystitis haemorrhagic 13.73 11.32 27 875571 3675 49725851
Liver transplant 13.72 11.32 73 875525 2059 49727467
Diffuse large B-cell lymphoma 13.68 11.32 51 875547 5611 49723915
Malaise 13.67 11.32 5413 870185 330119 49399407
Organising pneumonia 13.60 11.32 40 875558 4734 49724792
Extremity contracture 13.58 11.32 50 875548 1198 49728328
Embolic stroke 13.55 11.32 105 875493 3379 49726147
Aphasia 13.55 11.32 613 874985 27881 49701645
Exposure via ingestion 13.53 11.32 89 875509 2714 49726812
Percutaneous coronary intervention 13.52 11.32 17 875581 183 49729343
Impaired healing 13.45 11.32 1392 874206 68394 49661132
Drug tolerance decreased 13.38 11.32 98 875500 9062 49720464
Unresponsive to stimuli 13.38 11.32 653 874945 29956 49699570
Gastrointestinal ischaemia 13.30 11.32 16 875582 164 49729362
Sensitivity to weather change 13.26 11.32 56 875542 5945 49723581
Generalised tonic-clonic seizure 13.23 11.32 350 875248 25960 49703566
Administration site pain 13.18 11.32 33 875565 635 49728891
Aplasia 13.14 11.32 29 875569 3784 49725742
Cerebral amyloid angiopathy 13.12 11.32 15 875583 145 49729381
Renal papillary necrosis 13.08 11.32 18 875580 213 49729313
Lip haematoma 13.07 11.32 5 875593 3 49729523
Coronary artery dilatation 13.07 11.32 5 875593 3 49729523
Hypersensitivity 13.06 11.32 3416 872182 211745 49517781
Gastrointestinal ulcer 13.06 11.32 64 875534 1746 49727780
Feeding disorder 13.02 11.32 257 875341 10356 49719170
Ventricular extrasystoles 13.02 11.32 255 875343 10261 49719265
Vertebral artery stenosis 12.98 11.32 10 875588 55 49729471
Pneumonitis 12.96 11.32 400 875198 29110 49700416
Blood immunoglobulin E increased 12.94 11.32 13 875585 2346 49727180
Urinary tract infection 12.91 11.32 4196 871402 219824 49509702
Shoulder arthroplasty 12.91 11.32 103 875495 3345 49726181
Renal haemorrhage 12.91 11.32 37 875561 774 49728752
Viral mutation identified 12.90 11.32 6 875592 1623 49727903
Hiatus hernia 12.88 11.32 412 875186 17932 49711594
Lupus vasculitis 12.87 11.32 27 875571 460 49729066
Subclavian steal syndrome 12.84 11.32 8 875590 29 49729497
Blood pressure inadequately controlled 12.84 11.32 124 875474 4256 49725270
Tongue haematoma 12.83 11.32 11 875587 72 49729454
Herpes zoster 12.82 11.32 1052 874546 69734 49659792
Platelet count increased 12.81 11.32 336 875262 14204 49715322
Hypertensive heart disease 12.79 11.32 75 875523 2195 49727331
Leukaemia recurrent 12.76 11.32 3 875595 1251 49728275
Supraventricular extrasystoles 12.74 11.32 114 875484 3830 49725696
Glycosylated haemoglobin increased 12.74 11.32 256 875342 10350 49719176
Angiopathy 12.73 11.32 118 875480 4004 49725522
Brown-Sequard syndrome 12.73 11.32 6 875592 10 49729516
Pneumonia cytomegaloviral 12.73 11.32 9 875589 1932 49727594
Pelvic haematoma 12.71 11.32 28 875570 494 49729032
Leriche syndrome 12.66 11.32 7 875591 19 49729507
Urinary straining 12.65 11.32 8 875590 30 49729496
Blood urine present 12.62 11.32 301 875297 12532 49716994
Anaphylactic reaction 12.62 11.32 786 874812 53269 49676257
Ovarian hyperstimulation syndrome 12.61 11.32 23 875575 3221 49726305
Blood lactic acid increased 12.59 11.32 150 875448 5435 49724091
Aortic aneurysm rupture 12.57 11.32 28 875570 498 49729028
Peripheral artery thrombosis 12.55 11.32 60 875538 1620 49727906
Deafness 12.52 11.32 358 875240 15333 49714193
Hereditary angioedema 12.51 11.32 50 875548 5392 49724134
Blood potassium increased 12.50 11.32 372 875226 16026 49713500
Hypocapnia 12.48 11.32 22 875576 327 49729199
Vascular stent occlusion 12.47 11.32 9 875589 44 49729482
Aortic occlusion 12.46 11.32 8 875590 31 49729495
Cerebrovascular stenosis 12.46 11.32 8 875590 31 49729495
Respiratory arrest 12.46 11.32 637 874961 29372 49700154
Gastritis haemorrhagic 12.45 11.32 51 875547 1286 49728240
Cerebral thrombosis 12.45 11.32 57 875541 1511 49728015
Cerebral hyperperfusion syndrome 12.42 11.32 7 875591 20 49729506
Night sweats 12.41 11.32 705 874893 32869 49696657
Patent ductus arteriosus 12.40 11.32 30 875568 3790 49725736
Gangrene 12.39 11.32 130 875468 4562 49724964
Device kink 12.36 11.32 8 875590 1799 49727727
Immune-mediated myositis 12.33 11.32 43 875555 1002 49728524
Hyperlipidaemia 12.33 11.32 393 875205 17097 49712429
Peripheral swelling 12.32 11.32 3863 871735 202073 49527453
Electrocardiogram PR prolongation 12.30 11.32 32 875566 631 49728895
Capillary fragility increased 12.30 11.32 4 875594 0 49729526
Dermatitis acneiform 12.29 11.32 33 875565 4024 49725502
Myelodysplastic syndrome 12.23 11.32 186 875412 14946 49714580
Bezoar 12.22 11.32 51 875547 1297 49728229
Epstein-Barr virus associated lymphoproliferative disorder 12.22 11.32 7 875591 1682 49727844
Procedural haemorrhage 12.22 11.32 77 875521 2313 49727213
Injury associated with device 12.21 11.32 22 875576 3095 49726431
Oesophageal ulcer haemorrhage 12.21 11.32 23 875575 361 49729165
Capillary fragility test 12.18 11.32 7 875591 21 49729505
Choroidal haemorrhage 12.17 11.32 9 875589 46 49729480
Coronary artery insufficiency 12.17 11.32 11 875587 78 49729448
Infusion site nodule 12.13 11.32 45 875553 1082 49728444
Urine albumin/creatinine ratio increased 12.13 11.32 17 875581 205 49729321
Tonsillitis 12.12 11.32 44 875554 4879 49724647
Neutropenic sepsis 12.09 11.32 172 875426 13975 49715551
Vascular dementia 12.08 11.32 28 875570 512 49729014
Angiogram 12.07 11.32 10 875588 62 49729464
Nail ridging 12.07 11.32 20 875578 282 49729244
Androgenetic alopecia 12.04 11.32 14 875584 138 49729388
Fungal infection 12.01 11.32 411 875187 29554 49699972
Otitis media bacterial 11.99 11.32 5 875593 5 49729521
Otitis media staphylococcal 11.99 11.32 5 875593 5 49729521
Rheumatoid lung 11.98 11.32 15 875583 2450 49727076
Finger deformity 11.96 11.32 54 875544 5628 49723898
Peripheral coldness 11.95 11.32 247 875351 10036 49719490
Hand-eye coordination impaired 11.95 11.32 7 875591 22 49729504
Bundle branch block right 11.94 11.32 128 875470 4517 49725009
Brain stem infarction 11.93 11.32 35 875563 742 49728784
Neck deformity 11.92 11.32 10 875588 1968 49727558
Mucosal erosion 11.91 11.32 49 875549 1238 49728288
Ocular retrobulbar haemorrhage 11.91 11.32 12 875586 99 49729427
Myositis 11.91 11.32 198 875400 7722 49721804
Bone erosion 11.88 11.32 137 875461 11550 49717976
Cardiotoxicity 11.86 11.32 72 875526 6955 49722571
Jaundice cholestatic 11.85 11.32 138 875460 4973 49724553
Nail disorder 11.84 11.32 109 875489 9599 49719927
Mycobacterium tuberculosis complex test positive 11.84 11.32 8 875590 1758 49727768
Vitamin K deficiency 11.82 11.32 24 875574 399 49729127
Sinus arrhythmia 11.80 11.32 51 875547 1318 49728208
Ageusia 11.80 11.32 273 875325 11310 49718216
Cytomegalovirus infection reactivation 11.78 11.32 17 875581 2614 49726912
Analgesic drug level above therapeutic 11.76 11.32 15 875583 164 49729362
Menstruation delayed 11.76 11.32 5 875593 1426 49728100
Cerebellar infarction 11.68 11.32 61 875537 1708 49727818
Forced expiratory volume decreased 11.68 11.32 38 875560 4356 49725170
Catheterisation cardiac 11.66 11.32 114 875484 3926 49725600
Blood calcium increased 11.61 11.32 193 875405 7526 49722000
Brain compression 11.61 11.32 21 875577 319 49729207
Placental infarction 11.56 11.32 19 875579 266 49729260
Flatulence 11.56 11.32 622 874976 28836 49700690
Arthritis bacterial 11.55 11.32 54 875544 5575 49723951
Eyelid haematoma 11.53 11.32 5 875593 6 49729520
Post procedural pulmonary embolism 11.51 11.32 18 875580 241 49729285
Device related thrombosis 11.50 11.32 49 875549 1258 49728268
Pulmonary function test decreased 11.48 11.32 26 875572 3362 49726164
Brain death 11.46 11.32 85 875513 2698 49726828
Cerebral microhaemorrhage 11.46 11.32 11 875587 85 49729441
Leukoencephalopathy 11.45 11.32 32 875566 3851 49725675
Administration site swelling 11.43 11.32 42 875556 1005 49728521
Periorbital haematoma 11.41 11.32 33 875565 694 49728832
Splenic rupture 11.40 11.32 46 875552 1152 49728374
Vitreous haemorrhage 11.35 11.32 60 875538 1688 49727838
Haemorrhoidal haemorrhage 11.34 11.32 105 875493 3562 49725964
Bone pain 11.33 11.32 685 874913 46544 49682982

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 1366.69 13.23 5702 695062 104594 28769169
Gastrointestinal haemorrhage 1336.09 13.23 4534 696230 74999 28798764
Coronary artery disease 1021.21 13.23 2818 697946 41372 28832391
Drug ineffective 1015.43 13.23 4797 695967 358373 28515390
Acute myocardial infarction 792.07 13.23 2738 698026 45700 28828063
Labelled drug-drug interaction medication error 711.14 13.23 1136 699628 11023 28862740
Off label use 617.29 13.23 4386 696378 296414 28577349
Drug abuse 486.64 13.23 711 700053 79172 28794591
Upper gastrointestinal haemorrhage 475.04 13.23 1366 699398 20548 28853215
Angina pectoris 464.37 13.23 1585 699179 26265 28847498
Cardiac failure congestive 454.91 13.23 3241 697523 73340 28800423
Melaena 421.74 13.23 1658 699106 29518 28844245
Gastric haemorrhage 421.65 13.23 776 699988 8521 28865242
Vascular stent thrombosis 406.80 13.23 399 700365 2211 28871552
Angina unstable 393.45 13.23 825 699939 10040 28863723
Febrile neutropenia 386.61 13.23 1363 699401 110877 28762886
Cerebrovascular accident 381.71 13.23 3121 697643 73790 28799973
Product use in unapproved indication 305.08 13.23 1046 699718 85829 28787934
Lower gastrointestinal haemorrhage 296.64 13.23 623 700141 7590 28866173
Treatment failure 292.72 13.23 266 700498 36673 28837090
Coronary artery bypass 283.95 13.23 445 700319 4240 28869523
Death 276.79 13.23 6092 694672 335992 28537771
Chest pain 275.51 13.23 3948 696816 108025 28765738
Thrombosis in device 270.51 13.23 354 700410 2810 28870953
Coronary arterial stent insertion 264.27 13.23 390 700374 3507 28870256
Neutropenia 245.93 13.23 1969 698795 129742 28744021
Haemorrhage 238.71 13.23 1857 698907 43215 28830548
Cerebral haemorrhage 230.08 13.23 1402 699362 30024 28843739
Malignant neoplasm progression 222.59 13.23 946 699818 72913 28800850
Haematuria 216.54 13.23 1787 698977 42352 28831411
Haematemesis 209.90 13.23 1144 699620 23482 28850281
Syncope 206.39 13.23 2885 697879 78486 28795277
Coronary artery occlusion 198.52 13.23 608 700156 9486 28864277
Coronary artery stenosis 197.07 13.23 546 700218 8027 28865736
Rectal haemorrhage 188.79 13.23 1434 699330 33115 28840648
Subdural haematoma 187.87 13.23 892 699872 17301 28856462
Transient ischaemic attack 186.35 13.23 1063 699701 22207 28851556
Disease progression 179.67 13.23 1169 699595 80747 28793016
Haemorrhage intracranial 177.24 13.23 749 700015 13793 28859970
Gastric ulcer 175.88 13.23 730 700034 13331 28860432
Pyrexia 164.96 13.23 5378 695386 282244 28591519
Drug dependence 162.75 13.23 154 700610 20827 28852936
Myocardial ischaemia 161.98 13.23 781 699983 15247 28858516
Mucosal inflammation 157.64 13.23 319 700445 31276 28842487
Aspirin-exacerbated respiratory disease 155.63 13.23 101 700663 265 28873498
Bone marrow failure 153.96 13.23 258 700506 27191 28846572
Therapeutic product effect incomplete 153.45 13.23 451 700313 38854 28834909
Foetal exposure during pregnancy 153.24 13.23 361 700403 33506 28840257
Hospitalisation 149.86 13.23 571 700193 45417 28828346
Haematoma 147.98 13.23 1000 699764 22212 28851551
Dizziness 147.30 13.23 5689 695075 183995 28689768
Blood loss anaemia 144.14 13.23 439 700325 6827 28866936
Acute coronary syndrome 138.87 13.23 620 700144 11705 28862058
Epistaxis 135.40 13.23 1844 698920 49860 28823903
Cytomegalovirus infection 133.18 13.23 215 700549 23000 28850763
Drug resistance 130.75 13.23 192 700572 21348 28852415
Vascular stent stenosis 130.72 13.23 141 700623 889 28872874
Faeces discoloured 130.21 13.23 644 700120 12707 28861056
Haematochezia 129.62 13.23 1394 699370 35589 28838174
Sepsis 124.10 13.23 2509 698255 140173 28733590
Pancytopenia 121.99 13.23 1320 699444 81848 28791915
Subarachnoid haemorrhage 120.29 13.23 502 700262 9190 28864573
Post procedural haemorrhage 119.28 13.23 420 700344 7071 28866692
Duodenal ulcer 118.21 13.23 483 700281 8755 28865008
Septic shock 118.07 13.23 932 699832 61628 28812135
Graft versus host disease 116.79 13.23 41 700723 9587 28864176
Immune reconstitution inflammatory syndrome 111.89 13.23 24 700740 7778 28865985
Seizure 108.02 13.23 1554 699210 91569 28782194
Injection site pain 106.90 13.23 401 700363 32045 28841718
Pathogen resistance 106.59 13.23 30 700734 8086 28865677
Plasma cell myeloma 105.19 13.23 1343 699421 35772 28837991
Neurotoxicity 104.53 13.23 115 700649 14498 28859265
Gastric ulcer haemorrhage 104.21 13.23 304 700460 4610 28869153
Gastritis erosive 102.48 13.23 321 700443 5072 28868691
Psychotic disorder 100.26 13.23 207 700557 20147 28853616
Atrial fibrillation 100.02 13.23 3242 697522 102404 28771359
Coronary artery restenosis 99.50 13.23 122 700642 900 28872863
Rhabdomyolysis 98.56 13.23 2005 698759 58803 28814960
C-reactive protein abnormal 98.14 13.23 18 700746 6518 28867245
Condition aggravated 98.07 13.23 2677 698087 143618 28730145
Haemorrhagic stroke 97.30 13.23 333 700431 5523 28868240
Leukopenia 95.73 13.23 841 699923 54362 28819401
Coronary artery thrombosis 94.25 13.23 170 700594 1835 28871928
Suicidal ideation 94.16 13.23 462 700302 34254 28839509
Haemorrhagic arteriovenous malformation 93.52 13.23 75 700689 302 28873461
Product administration error 91.50 13.23 617 700147 13693 28860070
Bronchopulmonary aspergillosis 90.69 13.23 95 700669 12249 28861514
Vascular graft 89.13 13.23 135 700629 1245 28872518
Product use issue 88.64 13.23 785 699979 50659 28823104
Drug intolerance 88.39 13.23 727 700037 47652 28826111
Pneumocystis jirovecii pneumonia 87.51 13.23 165 700599 16614 28857149
Akathisia 86.56 13.23 26 700738 6716 28867047
Neuroleptic malignant syndrome 85.80 13.23 157 700607 15991 28857772
Acute graft versus host disease 85.41 13.23 17 700747 5807 28867956
Infective pulmonary exacerbation of cystic fibrosis 83.87 13.23 22 700742 6214 28867549
Stomatitis 83.67 13.23 525 700239 36588 28837175
Myelosuppression 83.37 13.23 100 700664 12127 28861636
Angioedema 81.79 13.23 1134 699630 30781 28842982
Status epilepticus 81.65 13.23 81 700683 10713 28863050
Aspergillus infection 80.50 13.23 79 700685 10502 28863261
Anaemia 80.47 13.23 5660 695104 195291 28678472
Small intestinal haemorrhage 80.09 13.23 156 700608 1793 28871970
Duodenal ulcer haemorrhage 80.01 13.23 261 700503 4218 28869545
Venoocclusive liver disease 79.64 13.23 32 700732 6885 28866878
Thrombosis 79.51 13.23 1448 699316 41597 28832166
Febrile bone marrow aplasia 78.34 13.23 38 700726 7313 28866450
Posterior reversible encephalopathy syndrome 78.05 13.23 59 700705 8917 28864846
Product dose omission issue 77.23 13.23 1717 699047 94666 28779097
Haematotoxicity 77.11 13.23 31 700733 6668 28867095
Diverticulum intestinal haemorrhagic 76.31 13.23 158 700606 1904 28871859
Mitral valve incompetence 74.41 13.23 555 700209 12738 28861025
Shock haemorrhagic 74.29 13.23 433 700331 9118 28864645
Hypotension 72.98 13.23 5446 695318 188908 28684855
Intraventricular haemorrhage 72.73 13.23 191 700573 2715 28871048
Bradycardia 72.53 13.23 2053 698711 63576 28810187
Intentional self-injury 71.85 13.23 115 700649 12346 28861417
Ischaemic cardiomyopathy 70.73 13.23 293 700471 5345 28868418
Carotid artery stenosis 70.67 13.23 250 700514 4219 28869544
Retroperitoneal haematoma 70.64 13.23 166 700598 2192 28871571
Drug ineffective for unapproved indication 70.47 13.23 144 700620 14070 28859693
Exposure to toxic agent 70.42 13.23 175 700589 2400 28871363
Multiple-drug resistance 70.01 13.23 6 700758 3894 28869869
Acute graft versus host disease in skin 69.70 13.23 13 700751 4651 28869112
Therapeutic response decreased 68.66 13.23 326 700438 24385 28849378
Vascular pseudoaneurysm 68.24 13.23 146 700618 1803 28871960
Wrong technique in product usage process 67.57 13.23 451 700313 30977 28842786
Infection 67.41 13.23 1347 699417 75404 28798359
Post transplant lymphoproliferative disorder 67.30 13.23 23 700741 5470 28868293
Aggression 66.78 13.23 530 700234 35011 28838752
Haemoglobin decreased 65.47 13.23 3168 697596 105207 28768556
Subdural haemorrhage 64.60 13.23 180 700584 2655 28871108
Ischaemic stroke 63.98 13.23 619 700145 15358 28858405
Enthesopathy 63.92 13.23 7 700757 3736 28870027
Exposure during pregnancy 63.78 13.23 65 700699 8489 28865274
Ventricular tachycardia 62.75 13.23 814 699950 21760 28852003
Iron deficiency anaemia 62.32 13.23 394 700370 8548 28865215
Serotonin syndrome 61.96 13.23 210 700554 17302 28856461
Acute myeloid leukaemia 61.91 13.23 193 700571 16320 28857443
Multiple organ dysfunction syndrome 61.83 13.23 1087 699677 62029 28811734
Ascites 61.66 13.23 562 700202 36057 28837706
Pain 61.47 13.23 3378 697386 168054 28705709
Fall 61.40 13.23 4934 695830 172244 28701519
Graft versus host disease in gastrointestinal tract 61.36 13.23 4 700760 3254 28870509
Interstitial lung disease 60.45 13.23 982 699782 56736 28817027
Internal haemorrhage 60.27 13.23 236 700528 4191 28869572
Dyspnoea 59.79 13.23 8718 692046 318014 28555749
Haemophagocytic lymphohistiocytosis 59.57 13.23 98 700666 10406 28863357
Thrombocytopenia 59.38 13.23 2600 698164 132223 28741540
Depression 59.08 13.23 1550 699214 83597 28790166
Presyncope 58.48 13.23 611 700153 15478 28858285
Arteriosclerosis 57.86 13.23 429 700335 9827 28863936
Progressive multifocal leukoencephalopathy 57.67 13.23 73 700691 8646 28865117
Occult blood positive 56.06 13.23 205 700559 3519 28870244
Graft versus host disease in skin 56.01 13.23 7 700757 3372 28870391
Cytomegalovirus viraemia 55.65 13.23 41 700723 6279 28867484
Haemorrhagic transformation stroke 55.46 13.23 106 700658 1200 28872563
Therapy partial responder 55.21 13.23 27 700737 5172 28868591
Thrombotic microangiopathy 55.04 13.23 75 700689 8606 28865157
Neoplasm progression 55.02 13.23 240 700524 18372 28855391
Chronic graft versus host disease 54.60 13.23 14 700750 4015 28869748
Sedation 54.19 13.23 220 700544 17185 28856578
Arteriosclerosis coronary artery 53.93 13.23 433 700331 10172 28863591
Therapeutic product effect decreased 53.58 13.23 443 700321 29008 28844755
Hepatocellular injury 52.93 13.23 291 700473 20952 28852811
Mania 52.78 13.23 77 700687 8586 28865177
International normalised ratio increased 52.67 13.23 1401 699363 42971 28830792
Pericardial haemorrhage 52.54 13.23 171 700593 2760 28871003
Drug withdrawal syndrome 52.49 13.23 233 700531 17751 28856012
Lymphopenia 52.28 13.23 156 700608 13377 28860386
BK virus infection 52.23 13.23 23 700741 4684 28869079
Myalgia 52.15 13.23 2198 698566 71821 28801942
Drug reaction with eosinophilia and systemic symptoms 51.86 13.23 419 700345 27573 28846190
Post procedural haematoma 51.67 13.23 109 700655 1332 28872431
Gastrointestinal vascular malformation haemorrhagic 51.55 13.23 65 700699 495 28873268
Osteonecrosis 51.39 13.23 157 700607 13362 28860401
Muscle haemorrhage 51.39 13.23 186 700578 3176 28870587
Pseudomonas infection 50.42 13.23 114 700650 10738 28863025
Cerebral infarction 49.46 13.23 841 699923 23834 28849929
Psoriatic arthropathy 49.41 13.23 180 700584 14511 28859252
Synovitis 49.31 13.23 116 700648 10774 28862989
Withdrawal syndrome 49.04 13.23 118 700646 10874 28862889
Injection site reaction 48.43 13.23 122 700642 11066 28862697
Arterial haemorrhage 48.36 13.23 73 700691 671 28873092
Heart rate decreased 47.39 13.23 842 699922 24070 28849693
Paradoxical drug reaction 47.13 13.23 5 700759 2736 28871027
Hiatus hernia 46.74 13.23 297 700467 6455 28867308
No adverse event 46.58 13.23 234 700530 17244 28856519
Mallory-Weiss syndrome 46.26 13.23 97 700667 1180 28872583
Drug hypersensitivity 46.19 13.23 1250 699514 67156 28806607
Diverticulum 46 13.23 282 700482 6050 28867713
Apparent death 45.93 13.23 13 700751 3491 28870272
Somnolence 45.11 13.23 1794 698970 92161 28781602
Loss of personal independence in daily activities 44.77 13.23 386 700378 25054 28848709
Joint swelling 44.47 13.23 868 699896 48762 28825001
Diastolic dysfunction 44.31 13.23 237 700527 4827 28868936
Vomiting 44.31 13.23 4379 696385 207881 28665882
Haemobilia 44.16 13.23 45 700719 263 28873500
Dystonia 44.02 13.23 104 700660 9645 28864118
Duodenitis 43.60 13.23 204 700560 3931 28869832
Dyspnoea exertional 43.55 13.23 1153 699611 35337 28838426
Gastritis 43.51 13.23 677 700087 18840 28854923
Epilepsy 43.49 13.23 257 700507 18175 28855588
Traumatic intracranial haemorrhage 43.18 13.23 63 700701 560 28873203
Intercepted product preparation error 43.18 13.23 3 700761 2314 28871449
Agitation 42.48 13.23 909 699855 50395 28823368
Pallor 42.29 13.23 717 700047 20307 28853456
Extradural haematoma 41.22 13.23 85 700679 1021 28872742
Arthralgia 41.22 13.23 2801 697963 136816 28736947
Obsessive-compulsive disorder 41.19 13.23 29 700735 4547 28869216
Gastritis haemorrhagic 41.11 13.23 91 700673 1152 28872611
Encephalopathy 41.06 13.23 504 700260 30539 28843224
Peptic ulcer 41.01 13.23 141 700623 2344 28871419
Neutrophil count decreased 40.86 13.23 756 700008 42811 28830952
Acute hepatic failure 40.69 13.23 448 700316 11504 28862259
Epstein-Barr virus infection 40.31 13.23 59 700705 6570 28867193
Adenovirus infection 40.27 13.23 28 700736 4419 28869344
C-reactive protein increased 40.00 13.23 773 699991 43490 28830273
Toxicity to various agents 39.88 13.23 3557 697207 170104 28703659
Diarrhoea 39.87 13.23 7108 693656 325590 28548173
Viral mutation identified 39.25 13.23 6 700758 2482 28871281
Suicide attempt 39.22 13.23 570 700194 33540 28840223
Spinal epidural haematoma 39.13 13.23 39 700725 221 28873542
Chest discomfort 39.11 13.23 1394 699370 44589 28829174
Retroperitoneal haemorrhage 38.92 13.23 140 700624 2383 28871380
Cytomegalovirus chorioretinitis 38.91 13.23 14 700750 3224 28870539
Cytokine release syndrome 38.88 13.23 169 700595 12950 28860813
Unintentional medical device removal 38.87 13.23 5 700759 2356 28871407
Abdominal wall haematoma 38.76 13.23 105 700659 1522 28872241
Percutaneous coronary intervention 38.64 13.23 36 700728 185 28873578
Drug withdrawal syndrome neonatal 38.61 13.23 16 700748 3379 28870384
Sinus node dysfunction 38.48 13.23 183 700581 3551 28870212
Product monitoring error 38.47 13.23 144 700620 2501 28871262
Cystitis haemorrhagic 38.18 13.23 35 700729 4807 28868956
Ventricular hypokinesia 38.16 13.23 211 700553 4354 28869409
Stent placement 38.00 13.23 202 700562 4104 28869659
Hepatitis B 37.43 13.23 45 700719 5452 28868311
Asthenia 37.30 13.23 5727 695037 209523 28664240
Alcohol abuse 37.01 13.23 29 700735 4304 28869459
Contusion 36.95 13.23 982 699782 30113 28843650
Swollen tongue 36.94 13.23 449 700315 11817 28861946
Irritability 36.84 13.23 341 700423 21811 28851952
Transplant rejection 36.45 13.23 105 700659 9107 28864656
Intermittent claudication 36.38 13.23 119 700645 1926 28871837
Lipodystrophy acquired 36.14 13.23 14 700750 3080 28870683
Venoocclusive disease 36.02 13.23 8 700756 2531 28871232
Hyperbilirubinaemia 35.89 13.23 207 700557 14727 28859036
Gastrointestinal ulcer haemorrhage 35.87 13.23 57 700707 550 28873213
Nausea 35.86 13.23 6168 694596 283087 28590676
Peripheral arterial occlusive disease 35.58 13.23 224 700540 4852 28868911
Cerebellar haemorrhage 35.54 13.23 93 700671 1319 28872444
Haemoptysis 35.50 13.23 962 699802 29588 28844175
Basilar artery thrombosis 35.05 13.23 31 700733 147 28873616
Accidental exposure to product 34.69 13.23 134 700630 10619 28863144
Cardiac failure 34.41 13.23 2249 698515 77038 28796725
Respiratory failure 34.36 13.23 1916 698848 95215 28778548
Abnormal behaviour 34.29 13.23 366 700398 22761 28851002
Cardiac disorder 34.29 13.23 1140 699624 36123 28837640
Tongue haematoma 34.19 13.23 26 700738 95 28873668
Blood pressure increased 34.14 13.23 2105 698659 71698 28802065
Tricuspid valve incompetence 33.99 13.23 326 700438 8068 28865695
Acute graft versus host disease in intestine 33.98 13.23 7 700757 2334 28871429
Hemiplegia 33.94 13.23 270 700494 6324 28867439
Colitis 33.92 13.23 528 700236 30720 28843043
Blood bilirubin increased 33.72 13.23 582 700182 33311 28840452
Cytopenia 33.68 13.23 120 700644 9739 28864024
Klebsiella infection 33.50 13.23 78 700686 7271 28866492
Candida infection 33.47 13.23 217 700547 15008 28858755
Cytomegalovirus infection reactivation 33.47 13.23 19 700745 3345 28870418
Cardiac tamponade 33.40 13.23 206 700558 4429 28869334
Ulcer haemorrhage 33.13 13.23 130 700634 2311 28871452
Coronary artery aneurysm 33.09 13.23 22 700742 61 28873702
Gastrointestinal arteriovenous malformation 33.01 13.23 41 700723 307 28873456
Generalised tonic-clonic seizure 32.97 13.23 292 700472 18847 28854916
Hyperammonaemia 32.89 13.23 52 700712 5611 28868152
Neutrophil count increased 32.47 13.23 210 700554 14532 28859231
Behaviour disorder 32.44 13.23 23 700741 3593 28870170
Euphoric mood 32.32 13.23 40 700724 4785 28868978
Peripheral vascular disorder 32.30 13.23 202 700562 4365 28869398
Heparin-induced thrombocytopenia 32.02 13.23 215 700549 4764 28868999
Gingival bleeding 32.01 13.23 262 700502 6191 28867572
Intentional product use issue 31.77 13.23 765 699999 41733 28832030
Drug use disorder 31.72 13.23 21 700743 3401 28870362
Thalamus haemorrhage 31.70 13.23 69 700695 863 28872900
Gastrointestinal ulcer 31.55 13.23 98 700666 1541 28872222
Eosinophilia 31.54 13.23 354 700410 21807 28851956
Eye haemorrhage 31.44 13.23 173 700591 3563 28870200
Cardiac ventricular thrombosis 31.34 13.23 69 700695 870 28872893
Mucormycosis 31.27 13.23 46 700718 5112 28868651
Fat embolism 31.14 13.23 30 700734 162 28873601
Haematocrit decreased 30.97 13.23 904 699860 28118 28845645
Cardiovascular disorder 30.92 13.23 336 700428 8599 28865164
Splenic haematoma 30.85 13.23 29 700735 151 28873612
Carotid artery occlusion 30.84 13.23 111 700653 1890 28871873
Vascular graft occlusion 30.73 13.23 51 700713 512 28873251
Enterococcal infection 30.73 13.23 97 700667 8171 28865592
Second primary malignancy 30.69 13.23 71 700693 6634 28867129
Therapy non-responder 30.69 13.23 531 700233 30380 28843383
Neutropenic sepsis 30.68 13.23 158 700606 11569 28862194
Hepatic function abnormal 30.66 13.23 702 700062 38557 28835206
Injection site erythema 30.63 13.23 199 700565 13757 28860006
Tenosynovitis 30.62 13.23 26 700738 3707 28870056
Blood pressure fluctuation 30.57 13.23 651 700113 19243 28854520
Peptic ulcer haemorrhage 30.53 13.23 46 700718 422 28873341
Tumour lysis syndrome 30.46 13.23 198 700566 13686 28860077
Hepatocellular carcinoma 30.27 13.23 77 700687 6961 28866802
Osteonecrosis of jaw 30.18 13.23 248 700516 16262 28857501
Electrocardiogram ST segment depression 30.17 13.23 117 700647 2068 28871695
Aplasia 30.15 13.23 31 700733 4032 28869731
Respiratory tract haemorrhage 30.12 13.23 69 700695 895 28872868
Developmental delay 30.07 13.23 11 700753 2507 28871256
Ventricular fibrillation 30.06 13.23 535 700229 15298 28858465
Pneumonia cytomegaloviral 29.92 13.23 13 700751 2669 28871094
Large intestinal haemorrhage 29.84 13.23 91 700673 1416 28872347
Bone erosion 29.82 13.23 14 700750 2746 28871017
Multiple injuries 29.71 13.23 101 700663 1669 28872094
Mitochondrial toxicity 29.70 13.23 10 700754 2401 28871362
Device use error 29.48 13.23 7 700757 2115 28871648
Haemorrhage urinary tract 29.41 13.23 94 700670 1502 28872261
Hypogammaglobulinaemia 29.15 13.23 60 700704 5847 28867916
Cerebral haematoma 29.14 13.23 188 700576 4108 28869655
Myelodysplastic syndrome 29.12 13.23 275 700489 17519 28856244
Embolic stroke 29.03 13.23 165 700599 3441 28870322
Subcapsular renal haematoma 29.01 13.23 41 700723 353 28873410
Large intestine polyp 28.98 13.23 258 700506 6251 28867512
Pulmonary alveolar haemorrhage 28.98 13.23 254 700510 6126 28867637
Syringe issue 28.98 13.23 28 700736 3750 28870013
Schizophrenia 28.87 13.23 71 700693 6494 28867269
Mobility decreased 28.87 13.23 433 700331 25347 28848416
Leukoencephalopathy 28.80 13.23 28 700736 3739 28870024
Sinus bradycardia 28.80 13.23 410 700354 11193 28862570
Hepatitis C 28.77 13.23 111 700653 8799 28864964
Haemorrhagic cerebral infarction 28.76 13.23 58 700706 685 28873078
Haemorrhagic erosive gastritis 28.68 13.23 24 700740 104 28873659
Pulmonary tuberculosis 28.67 13.23 36 700728 4279 28869484
Aortic stenosis 28.65 13.23 174 700590 3720 28870043
Cardiac failure chronic 28.62 13.23 256 700508 6211 28867552
Incorrect route of product administration 28.55 13.23 145 700619 10656 28863107
Disinhibition 28.51 13.23 13 700751 2594 28871169
Hepatitis B reactivation 28.36 13.23 21 700743 3208 28870555
Miosis 28.36 13.23 96 700668 7913 28865850
Angiocardiogram 28.27 13.23 29 700735 171 28873592
Bacterial infection 28.23 13.23 185 700579 12763 28861000
Hyperlipidaemia 28.17 13.23 437 700327 12153 28861610
Procedural haemorrhage 28.13 13.23 118 700646 2165 28871598
High density lipoprotein decreased 27.85 13.23 142 700622 2837 28870926
Arterial occlusive disease 27.82 13.23 174 700590 3760 28870003
Haemorrhagic infarction 27.68 13.23 42 700722 388 28873375
Pneumonia 27.68 13.23 6951 693813 313221 28560542
Gastrointestinal polyp haemorrhage 27.66 13.23 36 700728 284 28873479
Anxiety 27.66 13.23 1698 699066 83667 28790096
Carotid artery disease 27.56 13.23 62 700702 794 28872969
Herpes simplex 27.38 13.23 46 700718 4844 28868919
Mediastinal haematoma 27.36 13.23 22 700742 89 28873674
Blood pressure decreased 27.33 13.23 1329 699435 44148 28829615
Palmar-plantar erythrodysaesthesia syndrome 27.30 13.23 221 700543 14538 28859225
Rash maculo-papular 27.19 13.23 408 700356 23881 28849882
Device related infection 27.18 13.23 238 700526 15398 28858365
Coronary artery perforation 27.13 13.23 17 700747 41 28873722
Hyperthermia 27.02 13.23 123 700641 9307 28864456
Pulmonary haematoma 26.87 13.23 17 700747 42 28873721
Fungal infection 26.67 13.23 202 700562 13483 28860280
Staphylococcal infection 26.61 13.23 510 700254 28730 28845033
Gastrooesophageal reflux disease 26.57 13.23 954 699810 30542 28843221
Rheumatoid arthritis 26.51 13.23 570 700194 31582 28842181
Paranoia 26.45 13.23 132 700632 9745 28864018
Cerebral artery occlusion 26.44 13.23 54 700710 644 28873119
Subcutaneous haematoma 26.39 13.23 63 700701 841 28872922
Tuberculosis 26.34 13.23 85 700679 7111 28866652
Heart rate irregular 26.26 13.23 447 700317 12670 28861093
Agranulocytosis 26.23 13.23 332 700432 20008 28853755
Ventricular hypertrophy 26.15 13.23 182 700582 4082 28869681
Vascular stent occlusion 26.08 13.23 25 700739 134 28873629
Hypoglycaemia 26.02 13.23 1398 699366 46948 28826815
Basal ganglia haemorrhage 26.02 13.23 58 700706 738 28873025
Social avoidant behaviour 26.01 13.23 19 700745 2923 28870840
Ventricular extrasystoles 25.89 13.23 373 700391 10209 28863554
Cardiac aneurysm 25.87 13.23 59 700705 763 28873000
Systemic candida 25.85 13.23 17 700747 2763 28871000
Atrioventricular block complete 25.78 13.23 297 700467 7714 28866049
Hepatojugular reflux 25.69 13.23 43 700721 435 28873328
Pharyngeal haemorrhage 25.63 13.23 52 700712 617 28873146
Therapy interrupted 25.48 13.23 107 700657 8279 28865484
Device leakage 25.43 13.23 42 700722 4453 28869310
Urinary bladder haemorrhage 25.42 13.23 91 700673 1545 28872218
Muscle spasms 25.40 13.23 1830 698934 63252 28810511
Acute lymphocytic leukaemia recurrent 25.33 13.23 14 700750 2502 28871261
Left ventricular failure 25.32 13.23 193 700571 4460 28869303
Arterial restenosis 25.24 13.23 18 700746 58 28873705
Gout 25.22 13.23 551 700213 16360 28857403
Poisoning deliberate 25.19 13.23 62 700702 5669 28868094
Erythema 25.17 13.23 1500 699264 74106 28799657
Device issue 25.07 13.23 97 700667 7683 28866080
Metastases to liver 25.05 13.23 171 700593 11685 28862078
Blood creatine phosphokinase MB increased 25.01 13.23 95 700669 1662 28872101
Hyperammonaemic encephalopathy 24.96 13.23 8 700756 1982 28871781
Aortic aneurysm 24.91 13.23 241 700523 5979 28867784
Puncture site haemorrhage 24.90 13.23 32 700732 249 28873514
Hypertriglyceridaemia 24.86 13.23 92 700672 7383 28866380
Lymphoma 24.82 13.23 134 700630 9694 28864069
Helicobacter test positive 24.82 13.23 51 700713 611 28873152
Chromaturia 24.81 13.23 434 700330 12368 28861395
Myocardial rupture 24.67 13.23 25 700739 145 28873618
Head injury 24.64 13.23 526 700238 15555 28858208
Ecchymosis 24.50 13.23 242 700522 6038 28867725
Diffuse large B-cell lymphoma 24.49 13.23 72 700692 6204 28867559
Coronary angioplasty 24.44 13.23 37 700727 341 28873422
Haemothorax 24.32 13.23 152 700612 3284 28870479
Electrocardiogram abnormal 24.26 13.23 273 700491 7049 28866714
Respiratory distress 24.25 13.23 577 700187 31529 28842234
Atrial flutter 24.12 13.23 463 700301 13431 28860332
Nocardiosis 24.04 13.23 25 700739 3235 28870528
Body height decreased 24.03 13.23 152 700612 3298 28870465
Product storage error 23.98 13.23 76 700688 6394 28867369
Ventricular dysfunction 23.98 13.23 148 700616 3183 28870580
Scrotal haematoma 23.96 13.23 19 700745 75 28873688
Splenic rupture 23.82 13.23 82 700682 1364 28872399
Colonic haematoma 23.70 13.23 14 700750 29 28873734
Lymphadenopathy 23.69 13.23 434 700330 24615 28849148
Mouth haemorrhage 23.67 13.23 194 700570 4586 28869177
Hallucination, auditory 23.57 13.23 132 700632 9461 28864302
Growth retardation 23.53 13.23 5 700759 1631 28872132
Bacteraemia 23.52 13.23 260 700504 16063 28857700
Extrapyramidal disorder 23.49 13.23 155 700609 10676 28863087
Skin toxicity 23.49 13.23 33 700731 3738 28870025
Troponin increased 23.40 13.23 326 700438 8857 28864906
Lacunar infarction 23.37 13.23 130 700634 2689 28871074
Erosive duodenitis 23.20 13.23 76 700688 1231 28872532
Bleeding time prolonged 23.09 13.23 47 700717 559 28873204
Red blood cell sedimentation rate abnormal 22.92 13.23 13 700751 2290 28871473
Coma 22.84 13.23 736 700028 38714 28835049
Kidney transplant rejection 22.79 13.23 87 700677 6918 28866845
Acute respiratory distress syndrome 22.76 13.23 394 700370 22541 28851222
Electrocardiogram ST segment elevation 22.62 13.23 183 700581 4309 28869454
Orthostatic hypotension 22.56 13.23 699 700065 21930 28851833
Haemorrhage subcutaneous 22.52 13.23 105 700659 2020 28871743
Sudden cardiac death 22.47 13.23 142 700622 3080 28870683
Product prescribing error 22.31 13.23 571 700193 17405 28856358
Anion gap 22.25 13.23 52 700712 684 28873079
Hemiparesis 22.25 13.23 474 700290 14012 28859751
Disseminated intravascular coagulation 22.23 13.23 336 700428 19644 28854119
Product quality issue 22.19 13.23 255 700509 15640 28858123
Fatigue 22.17 13.23 8088 692676 308733 28565030
Hypomania 22.05 13.23 12 700752 2163 28871600
Catheter site haematoma 22.02 13.23 23 700741 139 28873624
Injection site swelling 21.84 13.23 132 700632 9285 28864478
Hypertensive crisis 21.80 13.23 283 700481 7565 28866198
Oesophageal intramural haematoma 21.73 13.23 11 700753 14 28873749
Labelled drug-disease interaction medication error 21.72 13.23 20 700744 101 28873662
Hypertension 21.72 13.23 3116 697648 113498 28760265
Tongue oedema 21.71 13.23 119 700645 2447 28871316
Myocarditis 21.69 13.23 161 700603 10795 28862968
Asthma 21.69 13.23 623 700141 33226 28840537
Strongyloidiasis 21.68 13.23 14 700750 2298 28871465
Dysmorphism 21.67 13.23 23 700741 2948 28870815
Disturbance in attention 21.60 13.23 367 700397 21057 28852706
Peripheral artery stenosis 21.54 13.23 56 700708 791 28872972
Glomerular filtration rate decreased 21.50 13.23 381 700383 10885 28862878
Device malfunction 21.48 13.23 116 700648 8391 28865372
Oesophageal ulcer 21.45 13.23 137 700627 2983 28870780
Bradypnoea 21.37 13.23 15 700749 2356 28871407
Musculoskeletal stiffness 21.17 13.23 701 700063 36757 28837006
Coagulopathy 21.12 13.23 565 700199 17342 28856421
Granulocytopenia 21.12 13.23 72 700692 5922 28867841
Surgery 21.05 13.23 178 700586 11601 28862162
Benign prostatic hyperplasia 20.94 13.23 392 700372 11318 28862445
Helicobacter gastritis 20.91 13.23 64 700700 998 28872765
Bundle branch block left 20.90 13.23 204 700560 5073 28868690
Human herpesvirus 6 infection 20.83 13.23 9 700755 1854 28871909
Dermatitis exfoliative generalised 20.80 13.23 23 700741 2893 28870870
Cerebral microhaemorrhage 20.68 13.23 15 700749 50 28873713
Chronic obstructive pulmonary disease 20.61 13.23 1177 699587 39778 28833985
Antipsychotic drug level increased 20.58 13.23 28 700736 3215 28870548
Nocturia 20.56 13.23 295 700469 8067 28865696
Neoplasm malignant 20.45 13.23 280 700484 16645 28857118
Salivary hypersecretion 20.43 13.23 98 700666 7311 28866452
Venous pressure jugular increased 20.42 13.23 50 700714 679 28873084
Sinus arrest 20.40 13.23 78 700686 1369 28872394
Occult blood 20.30 13.23 43 700721 527 28873236
Intra-abdominal haematoma 20.26 13.23 68 700696 1116 28872647
Coronary artery dissection 20.24 13.23 25 700739 186 28873577
Haemorrhoidal haemorrhage 20.20 13.23 132 700632 2897 28870866
Aortic aneurysm rupture 20.10 13.23 59 700705 898 28872865
Dermatitis acneiform 20.00 13.23 65 700699 5426 28868337
Cardiogenic shock 19.99 13.23 596 700168 18594 28855169
JC virus infection 19.92 13.23 10 700754 1887 28871876
Uveitis 19.91 13.23 73 700691 5874 28867889
Antipsychotic drug level below therapeutic 19.85 13.23 11 700753 1963 28871800
Angiopathy 19.84 13.23 153 700611 3549 28870214
Cerebral aspergillosis 19.80 13.23 4 700760 1352 28872411
Cerebrovascular disorder 19.66 13.23 88 700676 1663 28872100
Myoclonus 19.57 13.23 211 700553 13098 28860665
Foetal exposure timing unspecified 19.55 13.23 26 700738 210 28873553
Gastrointestinal angiodysplasia 19.51 13.23 42 700722 521 28873242
Spontaneous haematoma 19.48 13.23 39 700725 458 28873305
Autism spectrum disorder 19.48 13.23 12 700752 2020 28871743
Terminal state 19.44 13.23 33 700731 3461 28870302
Aortic intramural haematoma 19.41 13.23 12 700752 28 28873735
Blood creatine phosphokinase increased 19.29 13.23 1162 699602 39482 28834281
Non-cardiac chest pain 19.27 13.23 160 700604 3797 28869966
Incision site haemorrhage 19.26 13.23 39 700725 462 28873301
Coagulation time abnormal 19.18 13.23 21 700743 135 28873628
Cataract 19.17 13.23 679 700085 21699 28852064
Actinic elastosis 19.09 13.23 13 700751 38 28873725
Lymphoproliferative disorder 19.07 13.23 19 700745 2508 28871255
Precancerous skin lesion 19.06 13.23 42 700722 530 28873233
Pneumonia aspiration 19.03 13.23 695 700069 36042 28837721
Bladder tamponade 19.01 13.23 37 700727 425 28873338
Renal haemorrhage 19.00 13.23 70 700694 1206 28872557
Bundle branch block right 18.99 13.23 243 700521 6474 28867289
Epigastric discomfort 18.99 13.23 93 700671 1827 28871936
Carotid bruit 18.92 13.23 23 700741 168 28873595
Hypofibrinogenaemia 18.89 13.23 6 700758 1495 28872268
Ill-defined disorder 18.89 13.23 181 700583 11497 28862266
Respiratory depression 18.86 13.23 217 700547 13306 28860457
Lymphocyte count decreased 18.82 13.23 332 700432 18939 28854824
Angioplasty 18.80 13.23 57 700707 884 28872879
Hyphaema 18.78 13.23 38 700726 450 28873313
Ageusia 18.77 13.23 307 700457 8631 28865132
Cystic fibrosis 18.71 13.23 6 700758 1486 28872277
Haemorrhagic diathesis 18.64 13.23 116 700648 2502 28871261
Small intestine ulcer 18.61 13.23 35 700729 391 28873372
Juvenile idiopathic arthritis 18.59 13.23 5 700759 1389 28872374
Hyperreflexia 18.55 13.23 23 700741 2749 28871014
Haemarthrosis 18.54 13.23 122 700642 2684 28871079
Arteriovenous malformation 18.50 13.23 47 700717 654 28873109
Ankylosing spondylitis 18.49 13.23 45 700719 4131 28869632
Intestinal diaphragm disease 18.46 13.23 26 700738 223 28873540
Aortic valve sclerosis 18.43 13.23 51 700713 749 28873014
Prothrombin time prolonged 18.42 13.23 303 700461 8529 28865234
Full blood count decreased 18.41 13.23 503 700261 15489 28858274
Peripheral ischaemia 18.41 13.23 194 700570 4925 28868838
Vertigo 18.40 13.23 662 700102 21199 28852564
Blood glucose increased 18.37 13.23 1630 699134 57354 28816409
Aortic bypass 18.36 13.23 8 700756 5 28873758
Blindness transient 18.28 13.23 92 700672 1828 28871935
Disease recurrence 18.27 13.23 266 700498 15648 28858115
Muscular weakness 18.14 13.23 1707 699057 60345 28813418
Sickle cell anaemia with crisis 18.13 13.23 21 700743 2587 28871176
Coronary ostial stenosis 18.09 13.23 15 700749 64 28873699
Polyomavirus-associated nephropathy 18.06 13.23 33 700731 3363 28870400
Multiple sclerosis relapse 18.04 13.23 178 700586 11241 28862522
Conjunctival haemorrhage 18.03 13.23 116 700648 2532 28871231
Meningitis cryptococcal 18.01 13.23 14 700750 2086 28871677
Talipes 18.00 13.23 10 700754 1782 28871981
Page kidney 17.99 13.23 13 700751 43 28873720
Electrocardiogram QT prolonged 17.98 13.23 687 700077 35450 28838313
Basilar artery stenosis 17.97 13.23 9 700755 11 28873752
Tardive dyskinesia 17.96 13.23 64 700700 5194 28868569
Atrioventricular block first degree 17.93 13.23 199 700565 5120 28868643
Foetal anticonvulsant syndrome 17.93 13.23 3 700761 1161 28872602
Headache 17.90 13.23 3746 697018 170261 28703502
Colitis microscopic 17.87 13.23 86 700678 1677 28872086
Poisoning 17.86 13.23 151 700613 9842 28863921
Hepatic encephalopathy 17.85 13.23 210 700554 12825 28860938
Disturbance in social behaviour 17.83 13.23 9 700755 1693 28872070
Blood creatinine increased 17.82 13.23 2290 698474 82812 28790951
Philadelphia positive acute lymphocytic leukaemia 17.79 13.23 10 700754 18 28873745
Cerebral artery stenosis 17.78 13.23 28 700736 268 28873495
Ventricular arrhythmia 17.76 13.23 177 700587 4427 28869336
Aortic valve stenosis 17.76 13.23 101 700663 2107 28871656
Brain stem haemorrhage 17.66 13.23 53 700711 817 28872946
Essential hypertension 17.66 13.23 109 700655 2344 28871419
Blood cholesterol increased 17.53 13.23 489 700275 15106 28858657
Anger 17.52 13.23 169 700595 10721 28863042
Low density lipoprotein increased 17.51 13.23 155 700609 3749 28870014
Finger amputation 17.51 13.23 21 700743 151 28873612
Device embolisation 17.47 13.23 10 700754 19 28873744
Atrioventricular block 17.44 13.23 247 700517 6735 28867028
Fanconi syndrome 17.43 13.23 8 700756 1590 28872173
Computerised tomogram coronary artery abnormal 17.36 13.23 23 700741 185 28873578
Left ventricular dysfunction 17.32 13.23 302 700462 8600 28865163
Coronary artery insufficiency 17.29 13.23 15 700749 69 28873694
Hepatic failure 17.27 13.23 592 700172 30920 28842843
Reye's syndrome 17.27 13.23 8 700756 7 28873756
Metastases to lung 17.24 13.23 112 700652 7743 28866020
Periorbital haemorrhage 17.23 13.23 17 700747 95 28873668
Encephalitis 17.18 13.23 86 700678 6344 28867419
Viral load increased 17.14 13.23 14 700750 2035 28871728
Cardiac valve disease 17.14 13.23 121 700643 2727 28871036
Aortic valve incompetence 17.11 13.23 188 700576 4825 28868938
Brain stem stroke 17.05 13.23 20 700744 140 28873623
Arterial spasm 16.93 13.23 16 700748 84 28873679
Implant site haematoma 16.84 13.23 14 700750 60 28873703
Increased tendency to bruise 16.80 13.23 143 700621 3419 28870344
Small intestine polyp 16.78 13.23 9 700755 14 28873749
Vessel puncture site haematoma 16.76 13.23 12 700752 39 28873724
Gastrointestinal disorder 16.75 13.23 535 700229 28171 28845592
Arterial stenosis 16.74 13.23 62 700702 1071 28872692
Tooth disorder 16.70 13.23 318 700446 9211 28864552
Platelet dysfunction 16.68 13.23 23 700741 193 28873570
Polyneuropathy 16.56 13.23 196 700568 11956 28861807
Device interaction 16.55 13.23 39 700725 516 28873247
Intracardiac thrombus 16.54 13.23 102 700662 2193 28871570
Premature baby 16.46 13.23 299 700465 16981 28856782
Maternal drugs affecting foetus 16.43 13.23 43 700721 3850 28869913
Parkinsonism 16.37 13.23 103 700661 7175 28866588
COVID-19 16.34 13.23 692 700072 35322 28838441
Altered state of consciousness 16.28 13.23 353 700411 19536 28854227
Traumatic haematoma 16.15 13.23 44 700720 640 28873123
Multiple allergies 16.15 13.23 95 700669 2007 28871756
Tongue disorder 16.12 13.23 56 700708 4580 28869183
Alopecia 16.12 13.23 337 700427 18747 28855016
Brain contusion 16.10 13.23 46 700718 689 28873074
Cerebral ventricular rupture 16.08 13.23 20 700744 150 28873613
Aneurysm 16.06 13.23 79 700685 1555 28872208
Hypertensive heart disease 16.05 13.23 95 700669 2012 28871751
Silent myocardial infarction 15.97 13.23 28 700736 295 28873468
Drug level decreased 15.87 13.23 85 700679 6162 28867601
Electrocardiogram T wave inversion 15.83 13.23 91 700673 1906 28871857
Ischaemia 15.80 13.23 161 700603 4051 28869712
Hypocoagulable state 15.74 13.23 52 700712 846 28872917
Tremor 15.72 13.23 1514 699250 72024 28801739
Acute graft versus host disease in liver 15.72 13.23 6 700758 1332 28872431
Malaise 15.63 13.23 3444 697320 156158 28717605
Periorbital oedema 15.59 13.23 133 700631 3182 28870581
Vessel puncture site haemorrhage 15.59 13.23 14 700750 68 28873695
Pneumonia fungal 15.59 13.23 77 700687 5700 28868063
Cerebral toxoplasmosis 15.58 13.23 7 700757 1409 28872354
Platelet function test abnormal 15.52 13.23 16 700748 95 28873668
Naevus flammeus 15.51 13.23 19 700745 140 28873623
Hypotonia neonatal 15.51 13.23 5 700759 1234 28872529
Metastases to central nervous system 15.49 13.23 102 700662 7029 28866734
Diverticulitis intestinal haemorrhagic 15.48 13.23 28 700736 303 28873460
Blood pressure diastolic decreased 15.43 13.23 243 700521 6779 28866984
Wound haemorrhage 15.43 13.23 84 700680 1723 28872040
Stenosis 15.41 13.23 57 700707 984 28872779
Hypercholesterolaemia 15.35 13.23 249 700515 6989 28866774
Polycythaemia vera 15.34 13.23 23 700741 210 28873553
Pneumonitis 15.34 13.23 527 700237 27517 28846246
Muscle injury 15.32 13.23 61 700703 1092 28872671
Vertebral artery stenosis 15.25 13.23 18 700746 127 28873636
Blue toe syndrome 15.25 13.23 18 700746 127 28873636
Toxic anterior segment syndrome 15.24 13.23 3 700761 1033 28872730
Basal ganglia infarction 15.23 13.23 19 700745 143 28873620
Psychomotor hyperactivity 15.18 13.23 123 700641 8090 28865673
Coagulation factor VIII level decreased 15.17 13.23 7 700757 6 28873757
Diverticulum oesophageal 15.17 13.23 7 700757 6 28873757
Mycobacterial infection 15.14 13.23 13 700751 1843 28871920
Microcytic anaemia 15.10 13.23 91 700673 1940 28871823
Cardiac valve replacement complication 15.10 13.23 11 700753 37 28873726
Hernia 15.01 13.23 280 700484 8078 28865685
Ruptured cerebral aneurysm 15.01 13.23 17 700747 114 28873649
Stent-graft endoleak 14.98 13.23 10 700754 28 28873735
Complications of transplanted kidney 14.97 13.23 46 700718 3908 28869855
Cardiac murmur 14.97 13.23 230 700534 6383 28867380
Drug eruption 14.92 13.23 293 700471 16448 28857315
Maternal exposure during pregnancy 14.89 13.23 49 700715 4074 28869689
Prostatic adenoma 14.86 13.23 19 700745 147 28873616
Pharyngeal haematoma 14.84 13.23 12 700752 49 28873714
Affect lability 14.80 13.23 37 700727 3365 28870398
Cardiotoxicity 14.74 13.23 60 700704 4684 28869079
Faeces pale 14.68 13.23 64 700700 1195 28872568
Intestinal obstruction 14.68 13.23 346 700418 18931 28854832
Haemorrhoids 14.68 13.23 371 700393 11286 28862477
Extrasystoles 14.60 13.23 136 700628 3338 28870425
Oral candidiasis 14.58 13.23 173 700591 10549 28863214
Infarction 14.56 13.23 103 700661 2323 28871440
Anastomotic ulcer haemorrhage 14.56 13.23 9 700755 21 28873742
Thalamic infarction 14.56 13.23 40 700724 585 28873178
Metabolic acidosis 14.51 13.23 1058 699706 36604 28837159
Brain stem ischaemia 14.49 13.23 16 700748 104 28873659
Ocular retrobulbar haemorrhage 14.37 13.23 8 700756 14 28873749
Electrocardiogram PR prolongation 14.34 13.23 44 700720 687 28873076
Dilatation atrial 14.32 13.23 84 700680 1773 28871990
Disseminated cryptococcosis 14.32 13.23 5 700759 1173 28872590
Erosive oesophagitis 14.31 13.23 68 700696 1319 28872444
Sexual dysfunction 14.28 13.23 80 700684 5734 28868029
Dizziness postural 14.27 13.23 192 700572 5175 28868588
Vitreous haemorrhage 14.21 13.23 89 700675 1924 28871839
White blood cell count increased 14.19 13.23 735 700029 36781 28836982
Carcinogenicity 14.18 13.23 12 700752 53 28873710
Blood urea increased 14.16 13.23 808 699956 27304 28846459
Hypokalaemia 14.15 13.23 1011 699753 49192 28824571
Mood swings 14.14 13.23 107 700657 7144 28866619
Hypoalbuminaemia 14.12 13.23 166 700598 10139 28863624
Traumatic haemorrhage 14.12 13.23 41 700723 620 28873143
Orthostatic intolerance 14.08 13.23 41 700723 621 28873142
Hypovolaemic shock 14.06 13.23 212 700552 5860 28867903
Coronary revascularisation 14.02 13.23 9 700755 23 28873740
Mental disorder 14.02 13.23 218 700546 12687 28861076
Psychomotor skills impaired 14.02 13.23 26 700738 2635 28871128
Intracranial aneurysm 14.02 13.23 60 700704 1111 28872652
Diffuse large B-cell lymphoma recurrent 14.02 13.23 25 700739 2572 28871191
Small for dates baby 14.01 13.23 41 700723 3538 28870225
Coronary artery surgery 13.97 13.23 15 700749 94 28873669
Hyperthermia malignant 13.94 13.23 13 700751 1771 28871992
Toxic encephalopathy 13.92 13.23 59 700705 4553 28869210
Electrocardiogram Q wave abnormal 13.91 13.23 26 700738 289 28873474
Duodenitis haemorrhagic 13.84 13.23 14 700750 81 28873682
Haematoma muscle 13.83 13.23 52 700712 905 28872858
Haemoperitoneum 13.82 13.23 74 700690 1508 28872255
Oesophagitis haemorrhagic 13.80 13.23 22 700742 213 28873550
Oedema peripheral 13.79 13.23 2718 698046 100839 28772924
Alanine aminotransferase abnormal 13.79 13.23 31 700733 2926 28870837
Mouth ulceration 13.73 13.23 168 700596 10187 28863576
Extraocular muscle disorder 13.69 13.23 20 700744 178 28873585
Blood urine present 13.65 13.23 315 700449 9440 28864323
Barrett's oesophagus 13.64 13.23 32 700732 422 28873341
Disability 13.63 13.23 56 700708 4360 28869403
Kounis syndrome 13.63 13.23 82 700682 1747 28872016
Tic 13.62 13.23 14 700750 1821 28871942
Brain stem infarction 13.61 13.23 58 700706 1072 28872691
Catatonia 13.58 13.23 57 700707 4411 28869352
Hepatic necrosis 13.58 13.23 136 700628 3406 28870357
Hypospadias 13.57 13.23 32 700732 2970 28870793
Ejection fraction decreased 13.48 13.23 484 700280 15494 28858269
Drug abuser 13.46 13.23 46 700718 3781 28869982
Diverticulum intestinal 13.43 13.23 128 700636 3162 28870601
Hypertensive emergency 13.42 13.23 47 700717 789 28872974
Haemorrhage coronary artery 13.39 13.23 7 700757 10 28873753
Pneumatosis intestinalis 13.37 13.23 35 700729 3134 28870629
Rhythm idioventricular 13.37 13.23 24 700740 258 28873505
Orthopnoea 13.33 13.23 166 700598 4394 28869369
Sacroiliitis 13.33 13.23 5 700759 1122 28872641
Cardiac stress test abnormal 13.33 13.23 27 700737 320 28873443
Idiopathic pulmonary fibrosis 13.31 13.23 124 700640 3044 28870719
Logorrhoea 13.30 13.23 21 700743 2267 28871496
Splenic injury 13.29 13.23 9 700755 26 28873737
Cryptococcosis 13.27 13.23 16 700748 1936 28871827
Transplant failure 13.27 13.23 30 700734 2826 28870937
Pneumocystis jirovecii infection 13.27 13.23 9 700755 1439 28872324
Carcinoma in situ of skin 13.26 13.23 13 700751 72 28873691
Shone complex 13.26 13.23 13 700751 72 28873691
Platelet aggregation test 13.25 13.23 10 700754 36 28873727
Aplasia pure red cell 13.25 13.23 76 700688 5415 28868348
Incision site haematoma 13.24 13.23 14 700750 86 28873677
Implant site haemorrhage 13.24 13.23 14 700750 86 28873677
Psoriasis 13.23 13.23 626 700138 31601 28842162

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 2479.10 12.04 8086 1273004 157735 63059907
Gastrointestinal haemorrhage 2457.97 12.04 6964 1274126 125348 63092294
Drug ineffective 1633.13 12.04 9908 1271182 830339 62387303
Coronary artery disease 1594.15 12.04 3634 1277456 56799 63160843
Acute myocardial infarction 1459.63 12.04 3836 1277254 65882 63151760
Labelled drug-drug interaction medication error 1244.83 12.04 1844 1279246 20218 63197424
Cerebrovascular accident 1030.60 12.04 5425 1275665 132158 63085484
Cardiac failure congestive 973.98 12.04 5143 1275947 125437 63092205
Upper gastrointestinal haemorrhage 753.31 12.04 1954 1279136 33266 63184376
Melaena 741.67 12.04 2547 1278543 51001 63166641
Off label use 740.37 12.04 8526 1272564 624280 62593362
Angina pectoris 695.45 12.04 2224 1278866 42857 63174785
Angina unstable 638.84 12.04 1122 1279968 14345 63203297
Vascular stent thrombosis 599.56 12.04 513 1280577 2851 63214791
Treatment failure 504.11 12.04 971 1280119 115845 63101797
Lower gastrointestinal haemorrhage 464.22 12.04 922 1280168 13017 63204625
Gastric haemorrhage 458.98 12.04 900 1280190 12581 63205061
Coronary arterial stent insertion 457.19 12.04 565 1280525 5127 63212515
Aspirin-exacerbated respiratory disease 447.38 12.04 282 1280808 878 63216764
Coronary artery bypass 438.06 12.04 559 1280531 5256 63212386
Cerebral haemorrhage 437.43 12.04 2093 1278997 48997 63168645
Injection site pain 431.17 12.04 985 1280105 110423 63107219
Febrile neutropenia 409.80 12.04 2124 1278966 185533 63032109
Drug abuse 381.32 12.04 1348 1279742 131026 63086616
Syncope 374.43 12.04 4780 1276310 152855 63064787
Chest pain 373.28 12.04 6674 1274416 229306 62988336
Transient ischaemic attack 372.45 12.04 1802 1279288 42380 63175262
Haematuria 360.71 12.04 2245 1278845 58226 63159416
Haematemesis 351.28 12.04 1853 1279237 45146 63172496
Product use in unapproved indication 333.32 12.04 2096 1278994 174522 63043120
Rectal haemorrhage 325.41 12.04 2224 1278866 59593 63158049
Rhabdomyolysis 322.16 12.04 3007 1278083 88719 63128923
Thrombosis in device 321.38 12.04 448 1280642 4623 63213019
Drug intolerance 319.30 12.04 2302 1278788 185690 63031952
Injection site erythema 315.50 12.04 577 1280513 70223 63147419
Myocardial ischaemia 313.20 12.04 1096 1279994 22155 63195487
Coronary artery stenosis 308.22 12.04 687 1280403 10561 63207081
Exposure to toxic agent 305.43 12.04 485 1280605 5674 63211968
Coronary artery occlusion 304.53 12.04 778 1280312 13113 63204529
Haemorrhage 301.44 12.04 2646 1278444 76705 63140937
Device expulsion 300.41 12.04 34 1281056 21102 63196540
Neutropenia 298.91 12.04 3178 1277912 236446 62981196
Subdural haematoma 295.02 12.04 1222 1279868 26832 63190810
Malignant neoplasm progression 287.95 12.04 1207 1279883 111664 63105978
Haematoma 287.14 12.04 1735 1279355 44515 63173127
Completed suicide 280.43 12.04 6126 1274964 218288 62999354
Haemorrhage intracranial 277.30 12.04 1073 1280017 22811 63194831
Therapeutic product effect incomplete 275.01 12.04 1089 1280001 102393 63115249
Haematochezia 269.31 12.04 2246 1278844 64127 63153515
Pain 259.56 12.04 8702 1272388 544809 62672833
Gastric ulcer 259.05 12.04 1239 1279851 28995 63188647
Blood loss anaemia 256.23 12.04 730 1280360 13162 63204480
Injection site reaction 245.02 12.04 341 1280749 46323 63171319
Angioedema 244.47 12.04 2080 1279010 59741 63157901
Acute coronary syndrome 241.14 12.04 888 1280202 18422 63199220
Hypotension 236.13 12.04 9528 1271562 371446 62846196
Acute hepatic failure 236.11 12.04 1087 1280003 25025 63192617
Atrial fibrillation 235.00 12.04 4736 1276354 166353 63051289
Alopecia 233.95 12.04 2132 1278958 163558 63054084
Mucosal inflammation 218.06 12.04 584 1280506 62000 63155642
Condition aggravated 217.19 12.04 5683 1275407 366743 62850899
Product administration error 215.62 12.04 1103 1279987 26540 63191102
Duodenal ulcer 214.29 12.04 703 1280387 13732 63203910
Anaemia 206.83 12.04 9347 1271743 369333 62848309
Bone marrow failure 202.94 12.04 403 1280687 47549 63170093
Product use issue 201.43 12.04 1982 1279108 149733 63067909
Haemoglobin decreased 189.62 12.04 5146 1275944 189917 63027725
Vascular stent stenosis 188.51 12.04 177 1280913 1132 63216510
Disease progression 188.46 12.04 1850 1279240 139830 63077812
Product dose omission issue 188.01 12.04 2728 1278362 192019 63025623
Synovitis 186.79 12.04 1176 1279914 97914 63119728
Plasma cell myeloma 186.28 12.04 1558 1279532 44517 63173125
Cytomegalovirus infection 185.32 12.04 282 1280808 36917 63180725
C-reactive protein abnormal 185.02 12.04 182 1280908 28865 63188777
Epistaxis 184.19 12.04 2855 1278235 95276 63122366
Metabolic acidosis 183.10 12.04 2186 1278904 68772 63148870
Bradycardia 182.22 12.04 3331 1277759 114888 63102754
Drug resistance 176.90 12.04 264 1280826 34838 63182804
Injection site pruritus 176.90 12.04 299 1280791 37527 63180115
Injection site swelling 175.46 12.04 347 1280743 41006 63176636
Toxicity to various agents 174.58 12.04 8860 1272230 354653 62862989
Faeces discoloured 174.46 12.04 988 1280102 24741 63192901
Subarachnoid haemorrhage 173.75 12.04 777 1280313 17661 63199981
Psoriatic arthropathy 173.65 12.04 375 1280715 42906 63174736
Arthralgia 172.10 12.04 7109 1273981 435151 62782491
Gastric ulcer haemorrhage 170.20 12.04 448 1280642 7695 63209947
Gastritis erosive 170.00 12.04 497 1280593 9098 63208544
Post procedural haemorrhage 169.17 12.04 588 1280502 11843 63205799
Pyrexia 168.44 12.04 9227 1271863 549417 62668225
Loss of personal independence in daily activities 162.00 12.04 813 1280277 71641 63146001
Hypoglycaemia 161.77 12.04 2597 1278493 87295 63130347
Wrong technique in product usage process 160.02 12.04 704 1280386 64270 63153372
Hospitalisation 154.18 12.04 869 1280221 74338 63143304
International normalised ratio increased 152.28 12.04 2313 1278777 76854 63140788
Carotid artery stenosis 152.05 12.04 423 1280667 7518 63210124
Haemorrhagic stroke 149.84 12.04 487 1280603 9464 63208178
Myelosuppression 149.84 12.04 151 1280939 23679 63193963
Coagulopathy 146.88 12.04 1112 1279978 30808 63186834
Diverticulum intestinal haemorrhagic 146.62 12.04 246 1280844 3023 63214619
Neurotoxicity 144.11 12.04 200 1280890 27204 63190438
Coronary artery thrombosis 143.75 12.04 227 1280863 2642 63215000
Suicidal ideation 142.37 12.04 758 1280332 65784 63151858
Joint swelling 141.06 12.04 3229 1277861 212153 63005489
Infection 139.74 12.04 2708 1278382 182172 63035470
Intraventricular haemorrhage 136.23 12.04 273 1280817 3880 63213762
Dizziness 135.25 12.04 10103 1270987 420060 62797582
Haemorrhagic arteriovenous malformation 135.11 12.04 103 1280987 471 63217171
Ischaemic stroke 134.45 12.04 1013 1280077 28022 63189620
Duodenal ulcer haemorrhage 134.26 12.04 350 1280740 5975 63211667
Mitral valve incompetence 133.87 12.04 918 1280172 24620 63193022
Vascular pseudoaneurysm 133.39 12.04 230 1280860 2894 63214748
Musculoskeletal stiffness 133.23 12.04 1686 1279404 121520 63096122
Fall 132.25 12.04 9797 1271293 407029 62810613
Drug hypersensitivity 130.33 12.04 3660 1277430 234155 62983487
Pancytopenia 127.47 12.04 2039 1279051 141270 63076372
Coronary artery restenosis 127.41 12.04 143 1280947 1159 63216483
Arteriosclerosis coronary artery 127.00 12.04 628 1280462 14901 63202741
Vascular graft 126.51 12.04 170 1280920 1689 63215953
Haematotoxicity 126.12 12.04 49 1281041 12847 63204795
Acute kidney injury 125.51 12.04 10455 1270635 438785 62778857
Neoplasm progression 125.47 12.04 406 1280684 40558 63177084
Shock haemorrhagic 124.05 12.04 660 1280430 16131 63201511
Pathogen resistance 123.76 12.04 47 1281043 12496 63205146
Acute graft versus host disease 123.28 12.04 17 1281073 9067 63208575
Graft versus host disease 121.66 12.04 61 1281029 13752 63203890
Immune reconstitution inflammatory syndrome 120.93 12.04 48 1281042 12422 63205220
Arteriosclerosis 119.99 12.04 628 1280462 15249 63202393
Internal haemorrhage 119.79 12.04 380 1280710 7287 63210355
Infective pulmonary exacerbation of cystic fibrosis 118.41 12.04 43 1281047 11753 63205889
Cerebral infarction 116.88 12.04 1289 1279801 39755 63177887
Retroperitoneal haematoma 116.13 12.04 276 1280814 4435 63213207
Therapeutic response decreased 114.72 12.04 589 1280501 51599 63166043
Pneumocystis jirovecii pneumonia 114.57 12.04 235 1280855 27399 63190243
Posterior reversible encephalopathy syndrome 114.24 12.04 174 1280916 22772 63194870
Neuroleptic malignant syndrome 113.76 12.04 201 1280889 24795 63192847
Ischaemic cardiomyopathy 113.39 12.04 346 1280744 6492 63211150
Anion gap 112.48 12.04 161 1280929 1706 63215936
Aspergillus infection 108.56 12.04 99 1280991 16280 63201362
Blood pressure fluctuation 108.19 12.04 1537 1279553 50334 63167308
Pericardial haemorrhage 107.07 12.04 247 1280843 3889 63213753
Drug dependence 105.65 12.04 325 1280765 32987 63184655
Subdural haemorrhage 105.03 12.04 286 1280804 5017 63212625
Bronchopulmonary aspergillosis 104.71 12.04 135 1280955 18950 63198692
Device issue 102.28 12.04 183 1280907 22465 63195177
Leukopenia 101.21 12.04 1408 1279682 99834 63117808
Septic shock 100.25 12.04 1481 1279609 103956 63113686
Heart rate decreased 99.82 12.04 1593 1279497 53474 63164168
Rheumatoid nodule 99.76 12.04 64 1281026 12587 63205055
Haemorrhagic transformation stroke 99.55 12.04 174 1280916 2215 63215427
Acute myeloid leukaemia 98.91 12.04 252 1280838 27211 63190431
Intentional self-injury 96.70 12.04 277 1280813 28767 63188875
Hemiplegia 96.47 12.04 505 1280585 12263 63205379
Therapeutic product effect decreased 95.74 12.04 1662 1279428 113689 63103953
Febrile bone marrow aplasia 95.73 12.04 52 1281038 11203 63206439
Unintentional medical device removal 95.28 12.04 11 1281079 6723 63210919
Drug interaction 94.48 12.04 8385 1272705 353698 62863944
Thrombosis 94.39 12.04 1948 1279142 68694 63148948
Extradural haematoma 93.95 12.04 181 1280909 2495 63215147
Retroperitoneal haemorrhage 93.89 12.04 260 1280830 4608 63213034
Small intestinal haemorrhage 93.88 12.04 224 1280866 3609 63214033
Post procedural haematoma 92.69 12.04 165 1280925 2133 63215509
Status epilepticus 92.57 12.04 181 1280909 21482 63196160
Presyncope 92.26 12.04 1085 1280005 34004 63183638
Haemophagocytic lymphohistiocytosis 91.11 12.04 130 1280960 17479 63200163
Arthropathy 90.39 12.04 1775 1279315 119192 63098450
Drug ineffective for unapproved indication 90.26 12.04 316 1280774 30817 63186825
Ventricular tachycardia 89.42 12.04 1058 1280032 33207 63184435
Gastrointestinal vascular malformation haemorrhagic 89.24 12.04 88 1281002 603 63217039
Headache 88.37 12.04 9188 1271902 520279 62697363
Spinal epidural haematoma 88.25 12.04 116 1280974 1126 63216516
Diarrhoea 88.23 12.04 12801 1268289 709903 62507739
Contraindicated product administered 88.09 12.04 1558 1279532 106271 63111371
Acute graft versus host disease in skin 88.08 12.04 15 1281075 6840 63210802
Interstitial lung disease 88.06 12.04 1387 1279703 96345 63121297
Asthenia 87.22 12.04 9744 1271346 418300 62799342
Therapy non-responder 86.10 12.04 864 1280226 65035 63152607
Accidental exposure to product 85.91 12.04 254 1280836 26110 63191532
Granuloma skin 85.75 12.04 10 1281080 6064 63211578
Seizure 85.71 12.04 2591 1278499 164301 63053341
Systemic lupus erythematosus 84.65 12.04 1060 1280030 76552 63141090
Post transplant lymphoproliferative disorder 84.28 12.04 42 1281048 9502 63208140
Haemoptysis 84.12 12.04 1406 1279684 47642 63170000
Multiple-drug resistance 84.04 12.04 14 1281076 6488 63211154
Cytomegalovirus viraemia 83.72 12.04 56 1281034 10772 63206870
Epstein-Barr virus infection 83.34 12.04 75 1281015 12413 63205229
Rash 83.17 12.04 7909 1273181 450640 62767002
Hemiparesis 82.76 12.04 932 1280158 28895 63188747
Device difficult to use 82.27 12.04 46 1281044 9752 63207890
Dystonia 82.02 12.04 156 1280934 18709 63198933
Sepsis 81.80 12.04 3739 1277351 226602 62991040
Sinus bradycardia 81.56 12.04 753 1280337 22140 63195502
Blood pressure increased 81.45 12.04 4200 1276890 168352 63049290
Venoocclusive liver disease 81.28 12.04 49 1281041 9966 63207676
Migraine 80.13 12.04 826 1280264 61851 63155791
Mania 79.64 12.04 125 1280965 16161 63201481
Intentional product misuse 78.52 12.04 1936 1279154 70359 63147283
Occult blood positive 78.39 12.04 289 1280801 5998 63211644
Akathisia 78.17 12.04 68 1281022 11442 63206200
Psoriasis 77.94 12.04 980 1280110 70723 63146919
Swelling 77.75 12.04 2506 1278584 157712 63059930
Product monitoring error 77.73 12.04 262 1280828 5192 63212450
Device use error 77.14 12.04 17 1281073 6454 63211188
Panniculitis 75.55 12.04 41 1281049 8838 63208804
Nausea 75.47 12.04 14107 1266983 771693 62445949
Blood parathyroid hormone decreased 75.39 12.04 26 1281064 7340 63210302
Withdrawal syndrome 74.63 12.04 229 1280861 23263 63194379
Abdominal discomfort 74.49 12.04 2913 1278177 179409 63038233
Arthritis 74.32 12.04 1193 1279897 82621 63135021
Product prescribing error 74.32 12.04 1047 1280043 34222 63183420
Metastases to liver 74.21 12.04 236 1280854 23705 63193937
Chronic graft versus host disease 73.79 12.04 17 1281073 6259 63211383
Orthostatic hypotension 73.39 12.04 1321 1279769 45417 63172225
Cardiac failure 73.01 12.04 3272 1277818 129101 63088541
Osteonecrosis of jaw 72.79 12.04 477 1280613 39348 63178294
Graft versus host disease in gastrointestinal tract 72.73 12.04 12 1281078 5600 63212042
Graft versus host disease in skin 72.58 12.04 10 1281080 5337 63212305
Ascites 72.50 12.04 834 1280256 61167 63156475
Blood creatine phosphokinase increased 72.49 12.04 1597 1279493 56961 63160681
Abdominal wall haematoma 72.48 12.04 219 1280871 4086 63213556
Enthesopathy 71.67 12.04 52 1281038 9586 63208056
Erythema 71.47 12.04 3012 1278078 184058 63033584
Injection site warmth 71.03 12.04 98 1280992 13364 63204278
Medication error 69.44 12.04 1386 1279704 48580 63169062
Palmar-plantar erythrodysaesthesia syndrome 69.29 12.04 315 1280775 28504 63189138
Pallor 68.83 12.04 1118 1279972 37663 63179979
Thrombotic microangiopathy 68.73 12.04 142 1280948 16513 63201129
Paradoxical drug reaction 67.30 12.04 19 1281071 6101 63211541
Peripheral arterial occlusive disease 67.00 12.04 296 1280794 6691 63210951
Abortion spontaneous 66.50 12.04 265 1280825 24878 63192764
Therapy interrupted 66.04 12.04 192 1280898 19844 63197798
Hyperkalaemia 65.85 12.04 2544 1278546 98585 63119057
Hypersensitivity 65.73 12.04 3209 1277881 193243 63024399
Ecchymosis 64.79 12.04 489 1280601 13533 63204109
Transplant rejection 64.75 12.04 157 1280933 17244 63200398
Adenovirus infection 63.95 12.04 32 1281058 7223 63210419
C-reactive protein increased 63.72 12.04 1417 1279673 93492 63124150
Pemphigus 63.61 12.04 836 1280254 59865 63157777
Sinus node dysfunction 63.02 12.04 286 1280804 6542 63211100
Hand deformity 62.71 12.04 873 1280217 61898 63155744
Iron deficiency anaemia 62.57 12.04 688 1280402 21201 63196441
Myalgia 62.38 12.04 3797 1277293 154820 63062822
Ventricular fibrillation 61.93 12.04 736 1280354 23124 63194518
Drug reaction with eosinophilia and systemic symptoms 61.57 12.04 734 1280356 53483 63164159
Diverticulum 61.40 12.04 461 1280629 12737 63204905
Lacunar infarction 61.35 12.04 245 1280845 5287 63212355
Red blood cell sedimentation rate 61.16 12.04 3 1281087 3711 63213931
Therapy partial responder 61.00 12.04 68 1281022 10180 63207462
Intermittent claudication 60.77 12.04 165 1280925 2889 63214753
Psychotic disorder 60.77 12.04 419 1280671 34159 63183483
Heparin-induced thrombocytopenia 60.41 12.04 330 1280760 8149 63209493
Stent placement 60.40 12.04 245 1280845 5326 63212316
Analgesic drug level increased 60.35 12.04 137 1280953 2133 63215509
Transplant dysfunction 60.02 12.04 29 1281061 6679 63210963
Blood creatinine increased 59.64 12.04 3283 1277807 132499 63085143
Injection site rash 59.39 12.04 141 1280949 15601 63202041
Pregnancy 59.01 12.04 214 1280876 20651 63196991
Hypertensive emergency 59.00 12.04 136 1280954 2140 63215502
Overdose 58.93 12.04 3799 1277291 155767 63061875
Uterine perforation 58.78 12.04 21 1281069 5799 63211843
Multiple injuries 58.56 12.04 171 1280919 3128 63214514
Muscle haemorrhage 58.45 12.04 248 1280842 5505 63212137
Stomatitis 58.39 12.04 1693 1279397 107912 63109730
Gastritis 58.16 12.04 1179 1279911 41439 63176203
Cardiac disorder 58.03 12.04 1486 1279604 54330 63163312
Mood swings 57.86 12.04 167 1280923 17301 63200341
Multiple sclerosis relapse 57.68 12.04 530 1280560 40605 63177037
Heart rate irregular 57.44 12.04 813 1280277 26600 63191042
Ventricular hypertrophy 57.24 12.04 269 1280821 6247 63211395
Cerebellar haemorrhage 57.08 12.04 147 1280943 2490 63215152
Fear of injection 56.93 12.04 23 1281067 5889 63211753
Duodenitis 56.83 12.04 275 1280815 6466 63211176
Peptic ulcer 56.68 12.04 234 1280856 5129 63212513
Swollen tongue 56.67 12.04 993 1280097 33961 63183681
Chronic obstructive pulmonary disease 56.59 12.04 1829 1279261 69219 63148423
Depression 56.15 12.04 3021 1278069 180270 63037372
Haemobilia 55.87 12.04 53 1281037 344 63217298
Atrioventricular block complete 55.86 12.04 483 1280607 13935 63203707
Traumatic intracranial haemorrhage 55.53 12.04 85 1281005 961 63216681
Second primary malignancy 55.42 12.04 100 1280990 12237 63205405
Arterial haemorrhage 55.31 12.04 131 1280959 2100 63215542
Large intestinal haemorrhage 55.15 12.04 142 1280948 2405 63215237
Hypertension 54.78 12.04 5917 1275173 253344 62964298
Lymphopenia 54.46 12.04 293 1280797 25364 63192278
Peripheral ischaemia 54.36 12.04 318 1280772 8060 63209582
Glossodynia 54.36 12.04 930 1280160 63766 63153876
Haematocrit decreased 53.04 12.04 1442 1279648 53213 63164429
Myopathy 52.99 12.04 561 1280529 17119 63200523
Hepatic necrosis 52.03 12.04 317 1280773 8156 63209486
Human herpesvirus 6 infection 52.02 12.04 14 1281076 4640 63213002
Fibromyalgia 52.01 12.04 456 1280634 35275 63182367
Hyperprolactinaemia 52.00 12.04 9 1281081 4056 63213586
Injection site urticaria 51.71 12.04 89 1281001 11092 63206550
Drug withdrawal syndrome 51.67 12.04 386 1280704 30905 63186737
Tricuspid valve incompetence 51.66 12.04 541 1280549 16462 63201180
Joint stiffness 51.20 12.04 373 1280717 30031 63187611
Cardiac tamponade 51.12 12.04 307 1280783 7857 63209785
Disturbance in social behaviour 51.07 12.04 8 1281082 3879 63213763
Aortic stenosis 51.05 12.04 256 1280834 6109 63211533
Prothrombin time prolonged 50.76 12.04 507 1280583 15234 63202408
Virologic failure 50.73 12.04 5 1281085 3461 63214181
Ischaemia 50.34 12.04 281 1280809 6997 63210645
Red blood cell sedimentation rate abnormal 49.66 12.04 162 1280928 16144 63201498
Pharyngeal haemorrhage 49.38 12.04 87 1281003 1115 63216527
Metastases to bone 49.34 12.04 223 1280867 20212 63197430
Injection site bruising 49.13 12.04 473 1280617 35900 63181742
Diastolic dysfunction 48.89 12.04 323 1280767 8552 63209090
Device dislocation 48.84 12.04 235 1280855 20943 63196699
Surgery 48.53 12.04 344 1280746 27869 63189773
Red blood cell sedimentation rate increased 48.45 12.04 392 1280698 30843 63186799
Confusional state 48.02 12.04 5907 1275183 255237 62962405
Hepatocellular injury 47.76 12.04 622 1280468 44613 63173029
Cerebral haematoma 47.45 12.04 274 1280816 6911 63210731
Puncture site haemorrhage 47.43 12.04 57 1281033 501 63217141
Product storage error 47.35 12.04 123 1280967 13195 63204447
Device related infection 47.21 12.04 385 1280705 30241 63187401
Asthma 46.99 12.04 1486 1279604 93739 63123903
Neurologic neglect syndrome 46.80 12.04 101 1280989 1517 63216125
Thalamus haemorrhage 46.75 12.04 101 1280989 1518 63216124
Serotonin syndrome 46.47 12.04 527 1280563 38755 63178887
Troponin increased 46.33 12.04 489 1280601 14910 63202732
Tongue haematoma 46.26 12.04 37 1281053 184 63217458
Tenosynovitis 46.24 12.04 104 1280986 11729 63205913
Cardiovascular disorder 46.24 12.04 501 1280589 15380 63202262
Carotid artery occlusion 46.24 12.04 180 1280910 3837 63213805
Cardiac murmur 46.19 12.04 390 1280700 11173 63206469
Malaise 46.15 12.04 7036 1274054 389211 62828431
Cystitis haemorrhagic 46.05 12.04 54 1281036 7902 63209740
Coronary artery aneurysm 45.95 12.04 30 1281060 101 63217541
Blood pressure decreased 45.84 12.04 2123 1278967 84076 63133566
Gastritis haemorrhagic 45.81 12.04 123 1280967 2139 63215503
Mucormycosis 45.60 12.04 47 1281043 7294 63210348
Hyperlipidaemia 45.60 12.04 675 1280415 22301 63195341
Cardiogenic shock 45.56 12.04 901 1280189 31526 63186116
Dyspnoea 45.46 12.04 15422 1265668 703252 62514390
Osteoporosis 45.39 12.04 576 1280514 41504 63176138
Oesophageal intramural haematoma 45.14 12.04 28 1281062 84 63217558
Pseudomonas infection 45.09 12.04 192 1280898 17691 63199951
Pneumonia cytomegaloviral 44.96 12.04 15 1281075 4324 63213318
Blood creatine phosphokinase MB increased 44.75 12.04 134 1280956 2487 63215155
Dyspnoea exertional 44.55 12.04 1840 1279250 71890 63145752
Injection site mass 44.43 12.04 184 1280906 17086 63200556
Drug tolerance decreased 44.39 12.04 44 1281046 6954 63210688
BK virus infection 44.32 12.04 49 1281041 7363 63210279
Lymphoproliferative disorder 44.25 12.04 23 1281067 5080 63212562
Cytomegalovirus infection reactivation 44.19 12.04 30 1281060 5726 63211916
Arterial stenosis 44.19 12.04 90 1281000 1295 63216347
Peripheral vascular disorder 44.17 12.04 271 1280819 6990 63210652
Carotid artery thrombosis 44.07 12.04 105 1280985 1690 63215952
No adverse event 44.05 12.04 359 1280731 28202 63189440
Pulmonary alveolar haemorrhage 43.54 12.04 337 1280753 9401 63208241
Drug eruption 43.45 12.04 483 1280607 35653 63181989
Ankylosing spondylitis 43.39 12.04 60 1281030 8174 63209468
Cerebrovascular disorder 43.34 12.04 161 1280929 3354 63214288
Abortion incomplete 43.31 12.04 5 1281085 3056 63214586
Peptic ulcer haemorrhage 42.97 12.04 68 1281022 793 63216849
Blood urea increased 42.86 12.04 1165 1279925 42988 63174654
Complication of device insertion 42.85 12.04 23 1281067 4989 63212653
Bleeding time prolonged 42.60 12.04 81 1281009 1105 63216537
Benign prostatic hyperplasia 42.56 12.04 320 1280770 8845 63208797
Hepatitis B reactivation 42.44 12.04 22 1281068 4867 63212775
Neutropenic sepsis 42.39 12.04 279 1280811 22993 63194649
Vascular graft occlusion 42.38 12.04 59 1281031 608 63217034
Fungal infection 42.30 12.04 455 1280635 33796 63183846
Procedural haemorrhage 42.20 12.04 182 1280908 4070 63213572
Mallory-Weiss syndrome 42.18 12.04 130 1280960 2453 63215189
Acute graft versus host disease in intestine 41.99 12.04 10 1281080 3599 63214043
Neutrophil count decreased 41.97 12.04 1189 1279901 76007 63141635
Hepatotoxicity 41.85 12.04 1065 1280025 38897 63178745
Rheumatoid factor positive 41.61 12.04 468 1280622 34470 63183172
Metastases to lung 41.57 12.04 159 1280931 15105 63202537
Somnolence 41.54 12.04 3480 1277610 200165 63017477
Viral mutation identified 41.52 12.04 8 1281082 3338 63214304
Mediastinal haematoma 41.51 12.04 34 1281056 176 63217466
Head injury 41.38 12.04 898 1280192 31944 63185698
Gastrointestinal ulcer haemorrhage 41.35 12.04 77 1281013 1033 63216609
Cytomegalovirus chorioretinitis 41.33 12.04 23 1281067 4889 63212753
Haemothorax 41.16 12.04 198 1280892 4644 63212998
Breast cancer 41.11 12.04 375 1280715 28773 63188869
Electrocardiogram ST segment elevation 41.09 12.04 266 1280824 6993 63210649
Cardiac failure chronic 41.05 12.04 314 1280776 8727 63208915
Pulmonary tuberculosis 41.04 12.04 50 1281040 7194 63210448
Multiple organ dysfunction syndrome 41.01 12.04 1622 1279468 99791 63117851
Mobility decreased 40.81 12.04 1346 1279744 84494 63133148
Osteonecrosis 40.76 12.04 361 1280729 27868 63189774
Leukoencephalopathy 40.63 12.04 47 1281043 6920 63210722
Electrocardiogram ST segment depression 40.63 12.04 184 1280906 4205 63213437
Device malfunction 40.47 12.04 196 1280894 17437 63200205
Percutaneous coronary intervention 40.40 12.04 42 1281048 309 63217333
Gastrointestinal angiodysplasia 40.24 12.04 69 1281021 864 63216778
Atrioventricular block 40.21 12.04 390 1280700 11625 63206017
Ventricular dysfunction 40.20 12.04 209 1280881 5061 63212581
Coronary artery dissection 40.18 12.04 68 1281022 842 63216800
Rheumatoid arthritis 39.90 12.04 2767 1278323 161527 63056115
Hiatus hernia 39.88 12.04 587 1280503 19370 63198272
Metastases to central nervous system 39.80 12.04 142 1280948 13770 63203872
Candida infection 39.77 12.04 415 1280675 31004 63186638
Myelodysplastic syndrome 39.69 12.04 353 1280737 27226 63190416
Irritability 39.63 12.04 503 1280587 36243 63181399
Sinus arrest 39.33 12.04 143 1280947 2947 63214695
Basilar artery thrombosis 39.04 12.04 39 1281051 272 63217370
Diffuse large B-cell lymphoma 38.93 12.04 93 1280997 10268 63207374
Erosive duodenitis 38.89 12.04 96 1280994 1582 63216060
Aggression 38.70 12.04 665 1280425 45567 63172075
Knee arthroplasty 38.66 12.04 346 1280744 26653 63190989
Aortic aneurysm 38.36 12.04 270 1280820 7304 63210338
Microcytic anaemia 38.23 12.04 188 1280902 4450 63213192
Arterial occlusive disease 38.16 12.04 255 1280835 6778 63210864
Embolic stroke 38.04 12.04 246 1280844 6465 63211177
Lactic acidosis 37.89 12.04 1536 1279554 59874 63157768
Large intestine polyp 37.87 12.04 355 1280735 10482 63207160
Haemorrhagic erosive gastritis 37.67 12.04 47 1281043 431 63217211
Angiopathy 37.59 12.04 233 1280857 6032 63211610
Foot deformity 37.56 12.04 184 1280906 16320 63201322
Miosis 37.55 12.04 136 1280954 13130 63204512
Atrial flutter 37.54 12.04 567 1280523 18813 63198829
Tuberculosis 37.35 12.04 133 1280957 12905 63204737
Gastrointestinal ulcer 37.21 12.04 140 1280950 2935 63214707
Cystic fibrosis 37.14 12.04 11 1281079 3423 63214219
Carotid arteriosclerosis 37.13 12.04 108 1280982 1971 63215671
Herpes zoster 37.10 12.04 1244 1279846 77943 63139699
Metastases to lymph nodes 37.10 12.04 73 1281017 8644 63208998
Haemorrhagic infarction 37.02 12.04 57 1281033 648 63216994
Lymphadenopathy 37.02 12.04 678 1280412 46008 63171634
Inflammation 36.98 12.04 1000 1280090 64300 63153342
Epilepsy 36.91 12.04 457 1280633 33074 63184568
Peripheral artery stenosis 36.73 12.04 77 1281013 1132 63216510
Acute lymphocytic leukaemia recurrent 36.64 12.04 17 1281073 4009 63213633
Splenic rupture 36.53 12.04 112 1280978 2107 63215535
Staphylococcal infection 36.52 12.04 748 1280342 49930 63167712
Premature delivery 36.45 12.04 545 1280545 18044 63199598
Spontaneous haematoma 36.37 12.04 79 1281011 1192 63216450
Unevaluable event 36.15 12.04 746 1280344 49743 63167899
Amenorrhoea 36.14 12.04 46 1281044 6493 63211149
Agranulocytosis 35.96 12.04 538 1280552 37691 63179951
Vascular stent occlusion 35.87 12.04 31 1281059 175 63217467
Chromaturia 35.81 12.04 640 1280450 21971 63195671
Mouth haemorrhage 35.50 12.04 324 1280766 9495 63208147
Herpes simplex 35.43 12.04 100 1280990 10436 63207206
Coronary angioplasty 35.39 12.04 40 1281050 327 63217315
Device leakage 35.37 12.04 69 1281021 8197 63209445
Basal ganglia haemorrhage 35.34 12.04 83 1281007 1323 63216319
Oesophagitis haemorrhagic 35.33 12.04 51 1281039 545 63217097
Aplasia 35.31 12.04 52 1281038 6901 63210741
Ovarian cyst 35.29 12.04 107 1280983 10911 63206731
Atrioventricular block first degree 35.23 12.04 347 1280743 10387 63207255
Coagulation time abnormal 35.22 12.04 32 1281058 195 63217447
Bundle branch block right 35.19 12.04 335 1280755 9934 63207708
Pyroglutamic acidosis 35.18 12.04 57 1281033 679 63216963
Subcutaneous haematoma 35.14 12.04 119 1280971 2364 63215278
Strongyloidiasis 35.10 12.04 9 1281081 3081 63214561
Generalised tonic-clonic seizure 35.10 12.04 568 1280522 39289 63178353
Urinary bladder haemorrhage 34.82 12.04 114 1280976 2224 63215418
Ventricular extrasystoles 34.79 12.04 515 1280575 17014 63200628
Anion gap abnormal 34.66 12.04 48 1281042 492 63217150
Gastrointestinal polyp haemorrhage 34.61 12.04 44 1281046 412 63217230
Hallucination, auditory 34.55 12.04 196 1280894 16743 63200899
Carotid artery disease 34.52 12.04 108 1280982 2055 63215587
Toxic anterior segment syndrome 34.47 12.04 4 1281086 2435 63215207
Hypogammaglobulinaemia 34.45 12.04 98 1280992 10201 63207441
Dermatitis exfoliative generalised 34.40 12.04 40 1281050 5876 63211766
Product quality issue 34.38 12.04 402 1280688 29397 63188245
Gastrointestinal toxicity 34.29 12.04 33 1281057 5289 63212353
Diffuse large B-cell lymphoma recurrent 34.16 12.04 10 1281080 3136 63214506
Ulcer haemorrhage 34.16 12.04 178 1280912 4314 63213328
Unintended pregnancy 33.96 12.04 10 1281080 3124 63214518
Anxiety 33.74 12.04 3516 1277574 199133 63018509
Bundle branch block left 33.73 12.04 326 1280764 9708 63207934
Haemorrhagic cerebral infarction 33.50 12.04 78 1281012 1236 63216406
Renal haemorrhage 33.43 12.04 100 1280990 1855 63215787
Muscular weakness 33.28 12.04 2950 1278140 124388 63093254
Aortic valve incompetence 33.17 12.04 280 1280810 8021 63209621
Brain herniation 33.15 12.04 233 1280857 6300 63211342
Helicobacter test positive 33.05 12.04 68 1281022 986 63216656
Bacterial infection 33.05 12.04 326 1280764 24624 63193018
Secondary immunodeficiency 32.79 12.04 7 1281083 2717 63214925
Incorrect route of product administration 32.74 12.04 300 1280790 22998 63194644
Coronary artery perforation 32.74 12.04 21 1281069 68 63217574
Hyperammonaemia 32.57 12.04 95 1280995 9809 63207833
High density lipoprotein decreased 32.56 12.04 160 1280930 3786 63213856
Haemorrhage urinary tract 32.52 12.04 106 1280984 2063 63215579
Sleep disorder 32.37 12.04 920 1280170 58789 63158853
Lipodystrophy acquired 32.26 12.04 20 1281070 4007 63213635
Hip arthroplasty 32.18 12.04 270 1280820 21081 63196561
Injection site induration 32.13 12.04 82 1281008 8850 63208792
Colitis microscopic 32.02 12.04 255 1280835 7177 63210465
Oedema peripheral 31.99 12.04 4704 1276386 205613 63012029
Hepatitis B 31.99 12.04 66 1281024 7679 63209963
Aortic valve stenosis 31.79 12.04 177 1280913 4403 63213239
Exposure during pregnancy 31.69 12.04 1241 1279849 76434 63141208
Splenic haematoma 31.55 12.04 34 1281056 262 63217380
Dilatation atrial 31.46 12.04 144 1280946 3306 63214336
Juvenile idiopathic arthritis 31.45 12.04 19 1281071 3860 63213782
Respiratory tract haemorrhage 31.38 12.04 82 1281008 1402 63216240
Alcohol abuse 31.36 12.04 30 1281060 4822 63212820
Oral herpes 31.23 12.04 285 1280805 21867 63195775
Oesophageal ulcer 31.23 12.04 221 1280869 5989 63211653
Thrombocytopenia 31.18 12.04 3930 1277160 219871 62997771
Pregnancy with contraceptive device 31.14 12.04 12 1281078 3162 63214480
Sickle cell anaemia with crisis 31.06 12.04 36 1281054 5296 63212346
Subcapsular renal haematoma 30.77 12.04 52 1281038 643 63216999
Creatinine renal clearance decreased 30.74 12.04 429 1280661 13992 63203650
Diverticulum intestinal 30.56 12.04 252 1280838 7168 63210474
Cardiac arrest 30.56 12.04 3502 1277588 150562 63067080
Progressive multifocal leukoencephalopathy 30.54 12.04 224 1280866 18008 63199634
Hyphaema 30.33 12.04 50 1281040 605 63217037
Anosognosia 30.31 12.04 9 1281081 2796 63214846
Lung disorder 30.24 12.04 946 1280144 59754 63157888
Skin necrosis 30.21 12.04 164 1280926 14165 63203477
Gout 30.09 12.04 595 1280495 20818 63196824
Myocardial rupture 30.06 12.04 30 1281060 209 63217433
Electrocardiogram abnormal 29.94 12.04 404 1280686 13077 63204565
Cerebral ischaemia 29.81 12.04 316 1280774 9646 63207996
Sudden cardiac death 29.69 12.04 174 1280916 4413 63213229
Hepatojugular reflux 29.65 12.04 44 1281046 483 63217159
Angiocardiogram 29.64 12.04 30 1281060 213 63217429
Acute lung injury 29.53 12.04 120 1280970 2611 63215031
Infection reactivation 29.53 12.04 3 1281087 2027 63215615
Drug tolerance 29.47 12.04 47 1281043 6038 63211604
Oropharyngeal pain 29.42 12.04 1453 1279637 87414 63130228
Drug dose omission by device 29.36 12.04 16 1281074 3441 63214201
Rash maculo-papular 29.34 12.04 710 1280380 46316 63171326
Full blood count decreased 29.26 12.04 620 1280470 21962 63195680
Atrioventricular block second degree 29.22 12.04 224 1280866 6230 63211412
Klebsiella infection 29.12 12.04 150 1280940 13131 63204511
Hypertensive heart disease 29.11 12.04 151 1280939 3653 63213989
Oesophageal haemorrhage 28.98 12.04 83 1281007 1501 63216141
Brain contusion 28.84 12.04 71 1281019 1168 63216474
Cardiac aneurysm 28.73 12.04 73 1281017 1226 63216416
Adverse event 28.70 12.04 582 1280508 38907 63178735
Galactorrhoea 28.67 12.04 14 1281076 3205 63214437
Haemorrhage subcutaneous 28.60 12.04 166 1280924 4195 63213447
Ventricular arrhythmia 28.52 12.04 248 1280842 7167 63210475
Blood pressure diastolic decreased 28.48 12.04 611 1280479 21690 63195952
Adjustment disorder 28.41 12.04 119 1280971 2626 63215016
Bone erosion 28.32 12.04 126 1280964 11469 63206173
Mycobacterial infection 28.17 12.04 12 1281078 2976 63214666
Brain stem infarction 28.16 12.04 90 1281000 1733 63215909
Cerebral artery occlusion 28.11 12.04 83 1281007 1528 63216114
Brain stem haemorrhage 28.11 12.04 81 1281009 1470 63216172
Disability 28.11 12.04 135 1280955 12037 63205605
Reye's syndrome 28.09 12.04 13 1281077 16 63217626
Aortic aneurysm rupture 28.03 12.04 69 1281021 1135 63216507
Arterial restenosis 27.91 12.04 18 1281072 59 63217583
Ventricular hypokinesia 27.91 12.04 256 1280834 7513 63210129
Naevus flammeus 27.89 12.04 19 1281071 70 63217572
Diverticulitis intestinal haemorrhagic 27.80 12.04 40 1281050 426 63217216
Traumatic haemorrhage 27.79 12.04 66 1281024 1060 63216582
Anaphylactic shock 27.78 12.04 429 1280661 29899 63187743
Arrhythmia 27.72 12.04 1302 1279788 51642 63166000
Electrocardiogram PR prolongation 27.66 12.04 75 1281015 1312 63216330
Hepatic cirrhosis 27.61 12.04 362 1280728 25936 63191706
Varicella zoster virus infection 27.60 12.04 22 1281068 3866 63213776
Chronic kidney disease 27.54 12.04 1411 1279679 56508 63161134
Mental disorder 27.41 12.04 365 1280725 26080 63191562
Mood altered 27.40 12.04 195 1280895 15784 63201858
Adverse drug reaction 27.39 12.04 690 1280400 44774 63172868
Fat embolism 27.27 12.04 36 1281054 351 63217291
Polycythaemia vera 27.01 12.04 30 1281060 240 63217402
Disease recurrence 26.77 12.04 452 1280638 31058 63186584
Blood glucose increased 26.70 12.04 2279 1278811 95794 63121848
Encephalopathy 26.62 12.04 928 1280162 57891 63159751
Eosinophilia 26.55 12.04 565 1280525 37511 63180131
Alanine aminotransferase abnormal 26.54 12.04 61 1281029 6827 63210815
Venoocclusive disease 26.51 12.04 24 1281066 3961 63213681
Spinal cord haemorrhage 26.35 12.04 42 1281048 493 63217149
Potentiating drug interaction 26.34 12.04 255 1280835 7597 63210045
Activated partial thromboplastin time prolonged 26.27 12.04 379 1280711 12452 63205190
Intentional overdose 26.23 12.04 2101 1278989 87843 63129799
Antipsychotic drug level increased 26.23 12.04 38 1281052 5077 63212565
Gastrointestinal arteriovenous malformation 26.16 12.04 57 1281033 862 63216780
Pain in jaw 26.07 12.04 613 1280477 40142 63177500
Anti-cyclic citrullinated peptide antibody positive 26.02 12.04 767 1280323 48795 63168847
Acne 26.00 12.04 313 1280777 22768 63194874
Vomiting 25.98 12.04 10204 1270886 540913 62676729
Grip strength decreased 25.94 12.04 132 1280958 11592 63206050
Catatonia 25.86 12.04 72 1281018 7548 63210094
Low density lipoprotein increased 25.79 12.04 251 1280839 7489 63210153
Adrenal insufficiency 25.69 12.04 304 1280786 22183 63195459
Aneurysm 25.69 12.04 123 1280967 2879 63214763
Thinking abnormal 25.63 12.04 130 1280960 11426 63206216
Dermatitis acneiform 25.63 12.04 84 1281006 8359 63209283
Haemorrhoidal haemorrhage 25.61 12.04 198 1280892 5521 63212121
Colonic haematoma 25.54 12.04 18 1281072 71 63217571
Cerebral microhaemorrhage 25.49 12.04 25 1281065 170 63217472
Obsessive-compulsive disorder 25.49 12.04 35 1281055 4783 63212859
Normochromic normocytic anaemia 25.34 12.04 223 1280867 6467 63211175
Thrombotic stroke 25.33 12.04 48 1281042 653 63216989
Complication of device removal 25.31 12.04 17 1281073 3263 63214379
Urogenital haemorrhage 25.12 12.04 47 1281043 633 63217009
Cardiac valve disease 25.04 12.04 183 1280907 5012 63212630
Oesophageal mucosal dissection 25.02 12.04 12 1281078 17 63217625
Bone density decreased 25.00 12.04 107 1280983 9845 63207797
Blood prolactin increased 25.00 12.04 20 1281070 3508 63214134
White blood cell count decreased 24.99 12.04 2748 1278342 155089 63062553
Tumour lysis syndrome 24.92 12.04 256 1280834 19184 63198458
Intercepted product preparation error 24.90 12.04 4 1281086 1904 63215738
Helicobacter gastritis 24.85 12.04 98 1280992 2102 63215540
Small intestine ulcer 24.72 12.04 47 1281043 641 63217001
Mycobacterium chelonae infection 24.71 12.04 6 1281084 2131 63215511
Kidney transplant rejection 24.67 12.04 101 1280989 9410 63208232
International normalised ratio decreased 24.67 12.04 242 1280848 7236 63210406
Obliterative bronchiolitis 24.65 12.04 11 1281079 2654 63214988
Bacteraemia 24.53 12.04 381 1280709 26530 63191112
Tongue disorder 24.52 12.04 140 1280950 11940 63205702
Tongue oedema 24.44 12.04 203 1280887 5787 63211855
Haemoperitoneum 24.37 12.04 147 1280943 3768 63213874
Epstein-Barr virus associated lymphoproliferative disorder 24.29 12.04 16 1281074 3103 63214539
Skin toxicity 24.22 12.04 60 1281030 6542 63211100
Social avoidant behaviour 24.22 12.04 33 1281057 4524 63213118
Euphoric mood 24.10 12.04 60 1281030 6531 63211111
Wound haemorrhage 24.08 12.04 133 1280957 3298 63214344
Neoplasm malignant 24.07 12.04 345 1280745 24343 63193299
Vitreous haemorrhage 23.98 12.04 123 1280967 2962 63214680
COVID-19 23.97 12.04 1053 1280037 64087 63153555
Pericarditis 23.75 12.04 1007 1280083 61509 63156133
Conjunctival haemorrhage 23.71 12.04 176 1280914 4845 63212797
Cardiac ventricular thrombosis 23.68 12.04 72 1281018 1348 63216294
Mouth ulceration 23.63 12.04 478 1280612 31966 63185676
Scrotal haematoma 23.59 12.04 17 1281073 70 63217572
Non-cardiac chest pain 23.53 12.04 270 1280820 8410 63209232
Intracranial aneurysm 23.46 12.04 138 1280952 3505 63214137
Neutrophil count increased 23.43 12.04 355 1280735 24819 63192823
Illness 23.40 12.04 301 1280789 21637 63196005
Catheter site haematoma 23.38 12.04 32 1281058 324 63217318
Blood pressure systolic increased 23.35 12.04 1204 1279886 48249 63169393
Glomerular filtration rate decreased 23.34 12.04 531 1280559 19041 63198601
Device breakage 23.32 12.04 92 1280998 8663 63208979
Small intestinal ulcer haemorrhage 23.25 12.04 19 1281071 98 63217544
Vessel puncture site haematoma 23.18 12.04 23 1281067 159 63217483
Cerebral hyperperfusion syndrome 23.11 12.04 19 1281071 99 63217543
Hypovolaemic shock 22.94 12.04 308 1280782 9958 63207684
Maternal exposure during pregnancy 22.91 12.04 1617 1279473 94267 63123375
Cushingoid 22.83 12.04 76 1281014 7527 63210115
Platelet dysfunction 22.76 12.04 32 1281058 333 63217309
Cytopenia 22.71 12.04 197 1280893 15274 63202368
Device deployment issue 22.69 12.04 14 1281076 2812 63214830
Abortion early 22.66 12.04 10 1281080 10 63217632
Aortic valve sclerosis 22.63 12.04 76 1281014 1503 63216139
JC virus infection 22.57 12.04 20 1281070 3335 63214307
Carotid bruit 22.53 12.04 45 1281045 638 63217004
Vertebral artery stenosis 22.45 12.04 23 1281067 166 63217476
Cerebral artery stenosis 22.44 12.04 44 1281046 615 63217027
Ocular retrobulbar haemorrhage 22.37 12.04 20 1281070 119 63217523
Myositis 22.32 12.04 453 1280637 15924 63201718
Haemarthrosis 22.30 12.04 179 1280911 5050 63212592
Depressed level of consciousness 22.26 12.04 1893 1279197 79543 63138099
Essential hypertension 22.26 12.04 178 1280912 5016 63212626
Blood pressure inadequately controlled 22.25 12.04 183 1280907 5201 63212441
Electrocardiogram T wave inversion 22.23 12.04 170 1280920 4724 63212918
Drug specific antibody 22.14 12.04 7 1281083 2088 63215554
Periorbital oedema 22.10 12.04 235 1280855 7179 63210463
Acute myeloid leukaemia recurrent 22.07 12.04 14 1281076 2770 63214872
Leukaemia recurrent 22.04 12.04 12 1281078 2582 63215060
Nocardiosis 21.99 12.04 38 1281052 4729 63212913
Gestational diabetes 21.95 12.04 49 1281041 5541 63212101
Femur fracture 21.95 12.04 513 1280577 33622 63184020
Arteriovenous malformation 21.84 12.04 75 1281015 1501 63216141
Kounis syndrome 21.73 12.04 118 1280972 2907 63214735
Metastases to peritoneum 21.71 12.04 23 1281067 3524 63214118
Abnormal behaviour 21.70 12.04 505 1280585 33117 63184525
Colitis 21.69 12.04 948 1280142 57726 63159916
Basilar artery stenosis 21.66 12.04 12 1281078 27 63217615
Procedural pain 21.66 12.04 200 1280890 15308 63202334
Type V hyperlipidaemia 21.64 12.04 53 1281037 869 63216773
Implant site haematoma 21.61 12.04 21 1281069 141 63217501
Contusion 21.58 12.04 2583 1278507 111382 63106260
Systemic candida 21.51 12.04 46 1281044 5283 63212359
Blood potassium increased 21.51 12.04 672 1280418 25308 63192334
Enterococcal infection 21.51 12.04 174 1280916 13692 63203950
Coordination abnormal 21.43 12.04 417 1280673 14547 63203095
Pneumonia aspiration 21.43 12.04 960 1280130 58311 63159331
Pulmonary renal syndrome 21.36 12.04 40 1281050 539 63217103
Renal papillary necrosis 21.36 12.04 31 1281059 333 63217309
Poisoning deliberate 21.29 12.04 168 1280922 13290 63204352
Immunodeficiency 21.22 12.04 211 1280879 15913 63201729
Oculogyric crisis 21.19 12.04 12 1281078 2526 63215116
Pulmonary haematoma 21.17 12.04 18 1281072 99 63217543
Lymphoma 21.15 12.04 176 1280914 13765 63203877
Fusarium infection 21.14 12.04 3 1281087 1566 63216076
Deafness transitory 21.14 12.04 49 1281041 774 63216868
Hepatitis C 21.12 12.04 130 1280960 10885 63206757
Behaviour disorder 21.11 12.04 35 1281055 4427 63213215
Coronary artery insufficiency 21.05 12.04 22 1281068 163 63217479
Cytokine release syndrome 21.04 12.04 289 1280801 20540 63197102
Blood glucose decreased 21.01 12.04 605 1280485 22518 63195124
Acute graft versus host disease in liver 21.01 12.04 4 1281086 1683 63215959
Hypochromic anaemia 20.98 12.04 98 1280992 2270 63215372
Liver injury 20.92 12.04 759 1280331 29173 63188469
Cerebellar infarction 20.90 12.04 125 1280965 3194 63214448
Bradyarrhythmia 20.84 12.04 137 1280953 3621 63214021
Intra-abdominal haematoma 20.80 12.04 101 1280989 2378 63215264
Spinal cord haematoma 20.71 12.04 28 1281062 280 63217362
Dry eye 20.70 12.04 429 1280661 28590 63189052
Peripheral coldness 20.64 12.04 382 1280708 13202 63204440
Angioplasty 20.63 12.04 77 1281013 1608 63216034
Computerised tomogram coronary artery abnormal 20.62 12.04 23 1281067 185 63217457
Labile blood pressure 20.62 12.04 89 1281001 1991 63215651
Pyroglutamate increased 20.55 12.04 42 1281048 606 63217036
Bone pain 20.52 12.04 755 1280335 46817 63170825
Gastroduodenal haemorrhage 20.48 12.04 26 1281064 243 63217399
Frequent bowel movements 20.33 12.04 249 1280841 18056 63199586
Pelvic pain 20.27 12.04 130 1280960 10780 63206862
Neuropathy peripheral 20.24 12.04 2034 1279056 115491 63102151
Hypertensive crisis 20.20 12.04 490 1280600 17758 63199884
Suicide attempt 20.13 12.04 1179 1279911 69828 63147814
Paronychia 20.12 12.04 64 1281026 6428 63211214
Blood pH decreased 20.05 12.04 153 1280937 4249 63213393
Hyperammonaemic encephalopathy 19.98 12.04 31 1281059 4027 63213615
Stress 19.98 12.04 990 1280100 59544 63158098
Gingival bleeding 19.96 12.04 410 1280680 14444 63203198
Aphasia 19.95 12.04 999 1280091 39907 63177735
Crying 19.85 12.04 280 1280810 19810 63197832
Troponin T increased 19.84 12.04 96 1280994 2257 63215385
Labile hypertension 19.84 12.04 37 1281053 497 63217145
Extravasation blood 19.80 12.04 31 1281059 358 63217284
Hyperbilirubinaemia 19.74 12.04 299 1280791 20906 63196736
Discomfort 19.64 12.04 1362 1279728 79516 63138126
Labelled drug-disease interaction medication error 19.62 12.04 27 1281063 275 63217367
Affective disorder 19.60 12.04 66 1281024 6514 63211128
Hypertriglyceridaemia 19.58 12.04 136 1280954 11069 63206573
Blood urine present 19.57 12.04 490 1280600 17850 63199792
Left ventricular hypertrophy 19.54 12.04 281 1280809 9225 63208417
Incorrect dose administered by device 19.51 12.04 32 1281058 4065 63213577
Platelet function test abnormal 19.47 12.04 21 1281069 162 63217480
Silent myocardial infarction 19.32 12.04 42 1281048 634 63217008
Circulatory collapse 19.28 12.04 837 1280253 32895 63184747
Underdose 19.27 12.04 379 1280711 25450 63192192
Nodule 19.23 12.04 246 1280844 17701 63199941
Coagulation factor VIII level decreased 19.15 12.04 8 1281082 6 63217636
Platelet aggregation inhibition 19.08 12.04 19 1281071 132 63217510
Product substitution issue 19.07 12.04 245 1280845 17616 63200026
Electrocardiogram T wave abnormal 19.01 12.04 123 1280967 3233 63214409
Left ventricular failure 19.01 12.04 253 1280837 8164 63209478
Hepatocellular carcinoma 18.94 12.04 94 1280996 8309 63209333
Tardive dyskinesia 18.83 12.04 106 1280984 9072 63208570
Insurance issue 18.83 12.04 17 1281073 2809 63214833
Pneumatosis intestinalis 18.81 12.04 48 1281042 5181 63212461
Gastric mucosal lesion 18.81 12.04 49 1281041 836 63216806
Occult blood 18.80 12.04 66 1281024 1336 63216306
Vascular procedure complication 18.80 12.04 10 1281080 20 63217622
Sarcoidosis 18.76 12.04 61 1281029 6085 63211557
Extraocular muscle disorder 18.74 12.04 27 1281063 288 63217354
Polyneuropathy 18.70 12.04 280 1280810 19614 63198028
Foetal growth restriction 18.69 12.04 76 1281014 1654 63215988
Subclavian steal syndrome 18.68 12.04 12 1281078 39 63217603
Joint destruction 18.66 12.04 27 1281063 3609 63214033
Coronary artery surgery 18.64 12.04 21 1281069 171 63217471
Spinal operation 18.63 12.04 61 1281029 6072 63211570
Sexual dysfunction 18.54 12.04 66 1281024 6405 63211237
Periorbital haemorrhage 18.50 12.04 22 1281068 191 63217451
Necrotising myositis 18.50 12.04 49 1281041 845 63216797
Cerebral mass effect 18.47 12.04 75 1281015 1631 63216011
Coronary revascularisation 18.45 12.04 11 1281079 30 63217612
Intestinal obstruction 18.44 12.04 564 1280526 35722 63181920
Wheezing 18.42 12.04 1364 1279726 79215 63138427
Chronic gastrointestinal bleeding 18.42 12.04 31 1281059 382 63217260
Arthrodesis 18.40 12.04 9 1281081 2058 63215584
Insomnia 18.39 12.04 3556 1277534 194280 63023362
Craniocerebral injury 18.38 12.04 144 1280946 4032 63213610
Orthopnoea 18.38 12.04 269 1280821 8865 63208777
Platelet aggregation test 18.32 12.04 13 1281077 52 63217590
Philadelphia positive acute lymphocytic leukaemia 18.32 12.04 13 1281077 52 63217590
Tonsillitis 18.30 12.04 57 1281033 5763 63211879
Cardiotoxicity 18.30 12.04 124 1280966 10150 63207492
Metal poisoning 18.21 12.04 14 1281076 65 63217577
Aortic intramural haematoma 18.19 12.04 17 1281073 108 63217534
Syringe issue 18.15 12.04 36 1281054 4250 63213392
Haemodialysis 18.14 12.04 456 1280634 16621 63201021
Arteriovenous fistula 18.08 12.04 49 1281041 857 63216785
Arterial intramural haematoma 18.05 12.04 14 1281076 66 63217576
Cardiac stress test abnormal 18.05 12.04 43 1281047 692 63216950
Death 18.02 12.04 9008 1272082 473697 62743945
Chest discomfort 18.01 12.04 2600 1278490 113506 63104136
Stent-graft endoleak 17.97 12.04 11 1281079 32 63217610
Leriche syndrome 17.97 12.04 11 1281079 32 63217610
Dementia 17.96 12.04 540 1280550 20226 63197416
Pharyngeal haematoma 17.92 12.04 16 1281074 95 63217547
Cardiomegaly 17.90 12.04 606 1280484 23078 63194564
Meningitis cryptococcal 17.87 12.04 20 1281070 2989 63214653
Cholestasis 17.85 12.04 719 1280371 44153 63173489
Joint laxity 17.85 12.04 12 1281078 2302 63215340
Urine abnormality 17.76 12.04 224 1280866 7138 63210504
Mitral valve thickening 17.75 12.04 30 1281060 371 63217271
Viral load increased 17.75 12.04 14 1281076 2473 63215169
Cerebral thrombosis 17.67 12.04 88 1281002 2094 63215548
Rheumatoid lung 17.63 12.04 14 1281076 2465 63215177
Diabetic foot 17.56 12.04 111 1280979 2894 63214748
Persecutory delusion 17.54 12.04 35 1281055 4123 63213519
Eye haemorrhage 17.54 12.04 248 1280842 8112 63209530
Blood lactic acid increased 17.40 12.04 297 1280793 10104 63207538
Device interaction 17.32 12.04 41 1281049 657 63216985
Page kidney 17.29 12.04 13 1281077 58 63217584
Cerebral aspergillosis 17.29 12.04 6 1281084 1687 63215955
Uveitis 17.27 12.04 165 1280925 12543 63205099
Idiopathic pulmonary fibrosis 17.26 12.04 132 1280958 3668 63213974
Electrocardiogram Q wave abnormal 17.26 12.04 30 1281060 380 63217262
Toxic skin eruption 17.25 12.04 274 1280816 19010 63198632
Disturbance in attention 17.24 12.04 654 1280436 40420 63177222
Retinitis 17.20 12.04 10 1281080 2075 63215567
Mitochondrial toxicity 17.18 12.04 17 1281073 2689 63214953
Inguinal hernia 17.15 12.04 178 1280912 5403 63212239
Sinus rhythm 17.13 12.04 37 1281053 556 63217086
Immunosuppression 17.06 12.04 134 1280956 10612 63207030
Choroidal haemorrhage 17.06 12.04 18 1281072 135 63217507
Dysarthria 17.05 12.04 1386 1279704 58020 63159622
Incision site haemorrhage 17.01 12.04 50 1281040 918 63216724
Coagulation time prolonged 16.99 12.04 86 1281004 2060 63215582
Intracardiac thrombus 16.99 12.04 131 1280959 3650 63213992
Influenza 16.96 12.04 1854 1279236 104677 63112965
Anion gap increased 16.90 12.04 111 1280979 2933 63214709
Accidental overdose 16.88 12.04 822 1280268 32735 63184907
Haemorrhoids 16.87 12.04 609 1280481 23392 63194250
Acidosis 16.84 12.04 468 1280622 17327 63200315
Cerebral amyloid angiopathy 16.80 12.04 26 1281064 297 63217345
Dyskinesia 16.79 12.04 626 1280464 38762 63178880
Obstructive shock 16.73 12.04 12 1281078 49 63217593
Genital haemorrhage 16.72 12.04 55 1281035 5467 63212175
Urine albumin/creatinine ratio increased 16.70 12.04 27 1281063 321 63217321
Diabetic retinopathy 16.67 12.04 105 1280985 2734 63214908
Intestinal diaphragm disease 16.59 12.04 27 1281063 323 63217319
Tuberculin test positive 16.52 12.04 22 1281068 3046 63214596
Bladder tamponade 16.52 12.04 34 1281056 493 63217149
Subclavian artery stenosis 16.46 12.04 20 1281070 178 63217464
Post procedural myocardial infarction 16.45 12.04 11 1281079 39 63217603
Injection site haemorrhage 16.42 12.04 362 1280728 23916 63193726
Atrial thrombosis 16.33 12.04 110 1280980 2932 63214710
Loss of consciousness 16.32 12.04 3262 1277828 145103 63072539
Granuloma 16.32 12.04 72 1281018 6569 63211073
Oral candidiasis 16.31 12.04 344 1280746 22868 63194774
Personality disorder 16.30 12.04 154 1280936 4557 63213085
Rebound effect 16.29 12.04 47 1281043 4870 63212772
Metabolic disorder 16.28 12.04 88 1281002 7609 63210033
Incision site haematoma 16.26 12.04 17 1281073 126 63217516
Tendonitis 16.25 12.04 294 1280796 19988 63197654
Prinzmetal angina 16.22 12.04 66 1281024 1437 63216205
Vascular pseudoaneurysm ruptured 16.21 12.04 18 1281072 144 63217498
Arterial spasm 16.21 12.04 18 1281072 144 63217498
Intra-abdominal haemorrhage 16.12 12.04 136 1280954 3895 63213747
Endometriosis 16.10 12.04 19 1281071 2773 63214869
Hyperreflexia 16.09 12.04 80 1281010 7068 63210574
Hepatic cytolysis 16.09 12.04 379 1280711 13670 63203972
Traumatic liver injury 16.08 12.04 34 1281056 503 63217139
Eyelid haematoma 16.03 12.04 9 1281081 21 63217621
Injection site discolouration 16.02 12.04 76 1281014 6799 63210843
Hyperthermia 15.98 12.04 215 1280875 15335 63202307
Pneumocystis jirovecii infection 15.97 12.04 14 1281076 2347 63215295
Forced expiratory volume decreased 15.95 12.04 76 1281014 6791 63210851
Arterial stent insertion 15.95 12.04 14 1281076 81 63217561
Nasal disorder 15.91 12.04 105 1280985 2779 63214863
Dehydration 15.90 12.04 4680 1276410 212083 63005559
Osteomalacia 15.90 12.04 4 1281086 1387 63216255
Sleep disorder due to a general medical condition 15.88 12.04 97 1280993 8137 63209505
Otitis media staphylococcal 15.86 12.04 7 1281083 7 63217635
Pneumonia 15.83 12.04 10529 1270561 549047 62668595
Stem cell transplant 15.83 12.04 28 1281062 3453 63214189
Impaired work ability 15.79 12.04 210 1280880 15009 63202633
Prothrombin time abnormal 15.77 12.04 45 1281045 812 63216830
Rash pruritic 15.76 12.04 956 1280134 56448 63161194
QRS axis abnormal 15.74 12.04 75 1281015 1752 63215890
Thrombotic thrombocytopenic purpura 15.71 12.04 185 1280905 5799 63211843
Retinal artery occlusion 15.60 12.04 105 1280985 2798 63214844
Liver function test increased 15.58 12.04 482 1280608 30488 63187154
Haemorrhagic ascites 15.53 12.04 23 1281067 252 63217390
Precancerous skin lesion 15.49 12.04 54 1281036 1089 63216553
Duodenitis haemorrhagic 15.46 12.04 16 1281074 117 63217525
Skin flap necrosis 15.46 12.04 10 1281080 33 63217609
Systemic mycosis 15.44 12.04 14 1281076 2309 63215333
Hypofibrinogenaemia 15.44 12.04 8 1281082 1770 63215872
Respiratory rate increased 15.40 12.04 475 1280615 17856 63199786
Jaundice cholestatic 15.40 12.04 250 1280840 8420 63209222
Hyponatraemia 15.37 12.04 3252 1277838 145087 63072555
Respiratory alkalosis 15.33 12.04 131 1280959 3766 63213876
Neoplasm recurrence 15.33 12.04 32 1281058 3707 63213935
Influenza like illness 15.32 12.04 1037 1280053 60665 63156977
Psychotic symptom 15.30 12.04 12 1281078 2126 63215516
Myocardial necrosis marker increased 15.29 12.04 101 1280989 2674 63214968
Anticoagulation drug level below therapeutic 15.27 12.04 59 1281031 1253 63216389
Lip haematoma 15.26 12.04 6 1281084 3 63217639
Medical device site thrombosis 15.25 12.04 10 1281080 34 63217608
Vascular access site haemorrhage 15.23 12.04 9 1281081 24 63217618
HELLP syndrome 15.17 12.04 39 1281051 660 63216982
Brain stem stroke 15.14 12.04 29 1281061 398 63217244
Ventricular internal diameter abnormal 15.13 12.04 17 1281073 138 63217504
Disseminated tuberculosis 15.11 12.04 31 1281059 3614 63214028
Terminal state 15.08 12.04 42 1281048 4402 63213240
Post procedural complication 15.05 12.04 542 1280548 20811 63196831
Cytomegalovirus test positive 15.05 12.04 52 1281038 5092 63212550
Coronary artery reocclusion 15.04 12.04 17 1281073 139 63217503
Respiratory tract congestion 15.03 12.04 228 1280862 15937 63201705
Aortic arteriosclerosis 14.98 12.04 220 1280870 7256 63210386
Carcinogenicity 14.96 12.04 13 1281077 74 63217568
Portal hypertension 14.93 12.04 68 1281022 6151 63211491
Brain death 14.92 12.04 155 1280935 4706 63212936
Pneumonia fungal 14.90 12.04 109 1280981 8768 63208874
Spinal subdural haematoma 14.86 12.04 20 1281070 199 63217443
Extrapyramidal disorder 14.86 12.04 286 1280804 19266 63198376
Sacroiliitis 14.84 12.04 23 1281067 2989 63214653
Mitral valve calcification 14.82 12.04 61 1281029 1335 63216307
Arteriospasm coronary 14.81 12.04 170 1280920 5295 63212347
Fine motor skill dysfunction 14.79 12.04 46 1281044 4653 63212989
ECG signs of myocardial ischaemia 14.77 12.04 26 1281064 333 63217309
Arterial disorder 14.76 12.04 73 1281017 1732 63215910
Oesophagitis 14.75 12.04 547 1280543 21083 63196559
Coronary artery dilatation 14.73 12.04 8 1281082 17 63217625
Gastric ulcer helicobacter 14.73 12.04 8 1281082 17 63217625
Encephalitis 14.73 12.04 169 1280921 12402 63205240
Genitourinary tract neoplasm 14.69 12.04 5 1281085 0 63217642
Pneumonitis 14.68 12.04 834 1280256 49531 63168111
Mediastinal haemorrhage 14.67 12.04 12 1281078 62 63217580
Ear haemorrhage 14.66 12.04 76 1281014 1838 63215804
Aneurysm ruptured 14.62 12.04 44 1281046 819 63216823
Nocturia 14.61 12.04 307 1280783 10858 63206784
Breast cancer stage I 14.61 12.04 8 1281082 1716 63215926
Panic attack 14.58 12.04 311 1280779 20642 63197000
Idiopathic intracranial hypertension 14.58 12.04 18 1281072 2575 63215067
Low density lipoprotein abnormal 14.58 12.04 24 1281066 290 63217352
Myxoedema coma 14.57 12.04 38 1281052 649 63216993
Haemorrhage coronary artery 14.56 12.04 7 1281083 10 63217632
Lung transplant 14.56 12.04 38 1281052 4070 63213572
Embedded device 14.55 12.04 20 1281070 2732 63214910
Gene mutation 14.51 12.04 12 1281078 2070 63215572
Infarction 14.48 12.04 131 1280959 3829 63213813
Focal dyscognitive seizures 14.48 12.04 27 1281063 3263 63214379
Hepatic ischaemia 14.48 12.04 49 1281041 973 63216669
Pulmonary oedema 14.48 12.04 1780 1279310 76894 63140748
Immune-mediated myositis 14.47 12.04 97 1280993 2581 63215061
Hemiataxia 14.46 12.04 10 1281080 38 63217604
Fanconi syndrome 14.45 12.04 17 1281073 2484 63215158
Toxic encephalopathy 14.40 12.04 125 1280965 9690 63207952
Blue toe syndrome 14.40 12.04 34 1281056 544 63217098
Crystal urine present 14.37 12.04 76 1281014 1853 63215789
Organising pneumonia 14.34 12.04 113 1280977 8942 63208700
Spur cell anaemia 14.34 12.04 13 1281077 79 63217563
Ischaemic cerebral infarction 14.33 12.04 80 1281010 1992 63215650
Skin haemorrhage 14.31 12.04 245 1280845 8340 63209302
Transplant failure 14.30 12.04 34 1281056 3760 63213882
Subarachnoid haematoma 14.30 12.04 14 1281076 95 63217547
Epstein-Barr viraemia 14.29 12.04 9 1281081 1788 63215854
Menstruation irregular 14.25 12.04 43 1281047 4392 63213250
Basal ganglia infarction 14.25 12.04 33 1281057 521 63217121
Haemodilution 14.23 12.04 16 1281074 130 63217512
Pain in extremity 14.21 12.04 5612 1275478 297473 62920169
Aortic valve disease 14.17 12.04 66 1281024 1527 63216115
Traumatic haematoma 14.15 12.04 76 1281014 1864 63215778
Drug use disorder 14.06 12.04 67 1281023 5987 63211655
Venous pressure jugular increased 14.06 12.04 56 1281034 1207 63216435
Brain stem ischaemia 14.03 12.04 20 1281070 211 63217431
Fistula 14.02 12.04 125 1280965 9636 63208006
Mycobacterium tuberculosis complex test positive 14.02 12.04 12 1281078 2035 63215607
Orthostatic intolerance 14.02 12.04 66 1281024 1534 63216108
Left-to-right cardiac shunt 13.98 12.04 14 1281076 98 63217544
Cardiac procedure complication 13.97 12.04 24 1281066 301 63217341
Aortic valve replacement 13.96 12.04 53 1281037 1116 63216526
Aortic bypass 13.91 12.04 10 1281080 41 63217601
Hypercalcaemia 13.91 12.04 497 1280593 30919 63186723
Hand-eye coordination impaired 13.89 12.04 8 1281082 20 63217622
Umbilical haemorrhage 13.89 12.04 8 1281082 20 63217622
Coronary ostial stenosis 13.87 12.04 16 1281074 134 63217508
Subchorionic haematoma 13.87 12.04 14 1281076 99 63217543
Post procedural stroke 13.87 12.04 14 1281076 99 63217543
Chronic gastritis 13.87 12.04 111 1280979 3129 63214513
Haemorrhagic cholecystitis 13.85 12.04 12 1281078 68 63217574
Erosive oesophagitis 13.85 12.04 94 1280996 2512 63215130
Peripheral artery thrombosis 13.85 12.04 105 1280985 2910 63214732
Faeces pale 13.82 12.04 93 1280997 2478 63215164
Heart valve incompetence 13.82 12.04 99 1280991 2694 63214948
Drop attacks 13.80 12.04 48 1281042 967 63216675
Ejection fraction decreased 13.78 12.04 700 1280390 28007 63189635
Peripheral artery occlusion 13.77 12.04 81 1281009 2057 63215585
Ovarian hyperstimulation syndrome 13.76 12.04 22 1281068 2823 63214819
Actinic elastosis 13.74 12.04 10 1281080 42 63217600
Injection site discomfort 13.72 12.04 41 1281049 4200 63213442
Right ventricular failure 13.71 12.04 323 1280767 21148 63196494
Glycosylated haemoglobin increased 13.70 12.04 416 1280674 15603 63202039
Dilatation ventricular 13.64 12.04 127 1280963 3743 63213899
Ectopic pregnancy 13.63 12.04 7 1281083 1557 63216085
Small intestine polyp 13.63 12.04 8 1281082 21 63217621
Periorbital haematoma 13.63 12.04 44 1281046 852 63216790
Femoral artery aneurysm 13.60 12.04 18 1281072 176 63217466
Malignant transformation 13.60 12.04 3 1281087 1138 63216504
Infective exacerbation of chronic obstructive airways disease 13.59 12.04 89 1281001 2349 63215293
Otitis media bacterial 13.59 12.04 6 1281084 6 63217636
Nonreassuring foetal heart rate pattern 13.59 12.04 6 1281084 6 63217636
Barrett's oesophagus 13.59 12.04 40 1281050 735 63216907
Scedosporium infection 13.59 12.04 4 1281086 1250 63216392
Growth retardation 13.59 12.04 7 1281083 1554 63216088
Aortic occlusion 13.57 12.04 14 1281076 102 63217540
Sensitivity to weather change 13.52 12.04 78 1281012 6636 63211006
Nasopharyngitis 13.52 12.04 3575 1277515 192498 63025144
Lip swelling 13.51 12.04 769 1280321 31138 63186504
Mesenteric artery thrombosis 13.51 12.04 32 1281058 513 63217129
Blood calcium decreased 13.50 12.04 629 1280461 24925 63192717
Anti factor VIII antibody positive 13.47 12.04 12 1281078 71 63217571
Trifascicular block 13.45 12.04 16 1281074 139 63217503
Myocardial haemorrhage 13.44 12.04 9 1281081 32 63217610
Vascular device infection 13.44 12.04 70 1281020 6110 63211532
Fungaemia 13.42 12.04 35 1281055 3750 63213892
Breast cancer stage II 13.42 12.04 6 1281084 1446 63216196
Cytomegalovirus colitis 13.42 12.04 37 1281053 3891 63213751
Labelled drug-drug interaction issue 13.42 12.04 27 1281063 385 63217257
Device inappropriate shock delivery 13.40 12.04 10 1281080 44 63217598
Bipolar disorder 13.38 12.04 79 1281011 6682 63210960
Myoclonus 13.36 12.04 388 1280702 24730 63192912
Eye excision 13.35 12.04 12 1281078 72 63217570
Electric shock 13.33 12.04 51 1281039 1078 63216564
Inferior vena cava dilatation 13.30 12.04 39 1281051 715 63216927
Foetal exposure during pregnancy 13.26 12.04 45 1281045 4431 63213211
Polyomavirus-associated nephropathy 13.26 12.04 51 1281039 4837 63212805
Personality change 13.25 12.04 108 1280982 8485 63209157
Wound 13.24 12.04 1323 1279767 75154 63142488
Hyperglycaemia 13.20 12.04 1394 1279696 59574 63158068
Implant site pain 13.18 12.04 11 1281079 1889 63215753
Vertebrobasilar insufficiency 13.17 12.04 18 1281072 182 63217460
Pericardial rub 13.16 12.04 7 1281083 14 63217628
Schizophrenia 13.14 12.04 150 1280940 11018 63206624
Uvulitis 13.13 12.04 6 1281084 7 63217635
Hypocoagulable state 13.12 12.04 72 1281018 1781 63215861
Left atrial dilatation 13.08 12.04 97 1280993 2669 63214973
Diabetes mellitus inadequate control 13.08 12.04 533 1280557 20788 63196854
Choroidal dystrophy 13.07 12.04 10 1281080 46 63217596
Cerebral ventricular rupture 13.05 12.04 27 1281063 393 63217249
Colitis ischaemic 13.03 12.04 354 1280736 13060 63204582
Gallbladder rupture 13.02 12.04 41 1281049 783 63216859
Intestinal haemorrhage 12.98 12.04 167 1280923 5347 63212295
Intestinal haematoma 12.96 12.04 16 1281074 145 63217497
Essential thrombocythaemia 12.96 12.04 16 1281074 145 63217497
Thalamic infarction 12.94 12.04 50 1281040 1062 63216580
Cerebral arteriosclerosis 12.90 12.04 39 1281051 728 63216914
Vascular graft complication 12.89 12.04 15 1281075 127 63217515
Encephalitis viral 12.89 12.04 17 1281073 2363 63215279
Jaundice hepatocellular 12.88 12.04 14 1281076 109 63217533
Patent ductus arteriosus 12.88 12.04 13 1281077 92 63217550
Haemoglobin increased 12.87 12.04 159 1280931 5042 63212600
Putamen haemorrhage 12.87 12.04 28 1281062 423 63217219
Renal artery stenosis 12.86 12.04 102 1280988 2867 63214775
Injection site inflammation 12.84 12.04 28 1281062 3193 63214449
Cardiac valve replacement complication 12.84 12.04 19 1281071 208 63217434
Sinus arrhythmia 12.80 12.04 72 1281018 1798 63215844
Enterocolitis 12.78 12.04 165 1280925 11853 63205789
Atheroembolism 12.77 12.04 20 1281070 231 63217411
Deep vein thrombosis 12.75 12.04 2324 1278766 102858 63114784
Paraesthesia 12.69 12.04 2416 1278674 132106 63085536
Anger 12.67 12.04 228 1280862 15513 63202129
Laryngeal haematoma 12.65 12.04 16 1281074 149 63217493
Staphylococcal bacteraemia 12.61 12.04 138 1280952 10217 63207425
Platelet aggregation increased 12.61 12.04 14 1281076 112 63217530
Bone marrow disorder 12.60 12.04 23 1281067 2802 63214840
Nail ridging 12.59 12.04 22 1281068 280 63217362
Phimosis 12.58 12.04 27 1281063 404 63217238
Self-injurious ideation 12.57 12.04 28 1281062 3169 63214473
Steroid diabetes 12.53 12.04 21 1281069 2645 63214997
Stenosis 12.50 12.04 70 1281020 1745 63215897
Foot fracture 12.49 12.04 270 1280820 17887 63199755
Bone disorder 12.48 12.04 246 1280844 16513 63201129
Abortion induced 12.45 12.04 75 1281015 6313 63211329
Intracranial haematoma 12.43 12.04 40 1281050 773 63216869
Acute promyelocytic leukaemia 12.42 12.04 6 1281084 1382 63216260
Androgenetic alopecia 12.42 12.04 16 1281074 152 63217490
Corneal oedema 12.42 12.04 17 1281073 2326 63215316
Degenerative mitral valve disease 12.42 12.04 20 1281070 237 63217405
Blood HIV RNA increased 12.41 12.04 7 1281083 1477 63216165
Clostridium difficile infection 12.41 12.04 589 1280501 35574 63182068
Gastric occult blood positive 12.40 12.04 5 1281085 3 63217639
Dizziness postural 12.39 12.04 267 1280823 9485 63208157
Wrong technique in device usage process 12.38 12.04 24 1281066 2858 63214784
Bladder neoplasm 12.38 12.04 61 1281029 1445 63216197
Chest wall haematoma 12.35 12.04 25 1281065 358 63217284
Osteoarthritis 12.35 12.04 1086 1280004 62250 63155392
Skin reaction 12.26 12.04 172 1280918 12180 63205462
Haematoma muscle 12.25 12.04 69 1281021 1724 63215918
Memory impairment 12.24 12.04 1502 1279588 84180 63133462
Carotid artery dissection 12.23 12.04 23 1281067 311 63217331
Acute respiratory distress syndrome 12.23 12.04 640 1280450 38295 63179347
Ventricular asystole 12.19 12.04 20 1281070 241 63217401
Histoplasmosis disseminated 12.18 12.04 13 1281077 1985 63215657
Allergic respiratory disease 12.18 12.04 10 1281080 52 63217590
Angiogram 12.18 12.04 13 1281077 99 63217543
Cerebral toxoplasmosis 12.15 12.04 11 1281079 1815 63215827
Exercise tolerance decreased 12.13 12.04 218 1280872 7492 63210150
Musculoskeletal toxicity 12.12 12.04 16 1281074 156 63217486
Vascular graft thrombosis 12.10 12.04 18 1281072 198 63217444
Hernia 12.09 12.04 353 1280737 13165 63204477
Peripheral artery aneurysm 12.08 12.04 25 1281065 364 63217278

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cyst 21.67 15.27 9 963 18 83688
Urinary tract disorder 20.75 15.27 9 963 21 83685
Congenital acrochordon 18.07 15.27 9 963 32 83674
Congenital uterine anomaly 15.35 15.27 8 964 32 83674
Intestinal malrotation 15.35 15.27 8 964 32 83674
Rectourethral fistula 15.35 15.27 8 964 32 83674

Pharmacologic Action:

SourceCodeDescription
ATC A01AD05 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Other agents for local oral treatment
ATC B01AC06 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Platelet aggregation inhibitors excl. heparin
ATC B01AC56 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Platelet aggregation inhibitors excl. heparin
ATC C07FX02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
ATC C07FX03 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
ATC C07FX04 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
ATC C10BX01 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX02 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX04 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX05 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX06 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX08 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX12 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC M01BA03 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY/ANTIRHEUMATIC AGENTS IN COMBINATION
Antiinflammatory/antirheumatic agents in combination with corticosteroids
ATC N02AJ02 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ07 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ18 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02BA01 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
ATC N02BA51 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
ATC N02BA71 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
FDA CS M0001335 Anti-Inflammatory Agents, Non-Steroidal
FDA MoA N0000000160 Cyclooxygenase Inhibitors
FDA PE N0000008832 Decreased Platelet Aggregation
FDA PE N0000008836 Decreased Prostaglandin Production
FDA EPC N0000175578 Platelet Aggregation Inhibitor
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D058633 Antipyretics
MeSH PA D018501 Antirheumatic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D016861 Cyclooxygenase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005343 Fibrinolytic Agents
MeSH PA D006401 Hematologic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D010975 Platelet Aggregation Inhibitors
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory agent
CHEBI has role CHEBI:35493 anti-pyretic
CHEBI has role CHEBI:49023 prostaglandin inhibitor
CHEBI has role CHEBI:50249 anticoagulants
CHEBI has role CHEBI:50427 platelet aggregation inhibitors
CHEBI has role CHEBI:50629 COX-2 inhibitor
CHEBI has role CHEBI:50630 COX-1 inhibitor
CHEBI has role CHEBI:50905 teratogeno
CHEBI has role CHEBI:73182 plant activators
CHEBI has role CHEBI:77425 EC 1.1.1.188 (prostaglandin-F synthase) inhibitors
CHEBI has role CHEBI:88188 allergenic drug
CHEBI has role CHEBI:176497 geroprotectors
FDA EPC N0000175722 Nonsteroidal Anti-inflammatory Drug

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Sinus headache indication 4969004
Pain indication 22253000
Myocardial infarction indication 22298006 DOID:5844
Toothache indication 27355003
Migraine indication 37796009 DOID:6364
Joint pain indication 57676002
Rheumatoid arthritis indication 69896004 DOID:7148
Common cold indication 82272006 DOID:10459
Backache indication 161891005
Headache disorder indication 230461009
Influenza-like symptoms indication 315642008
Osteoarthritis indication 396275006
Arthritic Pain indication




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs Pain Indication
Dogs Inflammation Indication

🐶 Veterinary products

ProductApplicantIngredients
Cortaba Tablets Zoetis Inc. 2

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.57 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
325MG VAZALORE PLX PHARMA N203697 Jan. 14, 2013 OTC CAPSULE ORAL 9101637 March 23, 2022 TEMPORARY REDUCTION OF FEVER
325MG VAZALORE PLX PHARMA N203697 Jan. 14, 2013 OTC CAPSULE ORAL 9101637 March 23, 2022 TEMPORARY RELIEF OF MINOR ACHES AND PAINS
325MG VAZALORE PLX PHARMA N203697 Jan. 14, 2013 OTC CAPSULE ORAL 9101637 March 23, 2022 TREATMENT/PREVENTION OF CARDIOVASCULAR DISEASE
325MG;40MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 DISCN TABLET, DELAYED RELEASE ORAL 9364439 May 31, 2022 TREATMENT OR SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE, CARDIOVASCULAR EVENTS, OR CEREBROVASCULAR EVENTS AND RISK-REDUCTION OF ASPIRIN-ASSOCIATED GASTRIC ULCERS
81MG;40MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 DISCN TABLET, DELAYED RELEASE ORAL 9364439 May 31, 2022 TREATMENT OR SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE, CARDIOVASCULAR EVENTS, OR CEREBROVASCULAR EVENTS AND RISK-REDUCTION OF ASPIRIN-ASSOCIATED GASTRIC ULCERS
325MG;40MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 DISCN TABLET, DELAYED RELEASE ORAL 6926907 Feb. 28, 2023 TREATMENT OR SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE, CARDIOVASCULAR EVENTS, OR CEREBROVASCULAR EVENTS AND RISK-REDUCTION OF ASPIRIN-ASSOCIATED GASTRIC ULCERS
325MG;40MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 DISCN TABLET, DELAYED RELEASE ORAL 8206741 Feb. 28, 2023 TREATMENT OR SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE, CARDIOVASCULAR EVENTS, OR CEREBROVASCULAR EVENTS AND RISK-REDUCTION OF ASPIRIN-ASSOCIATED GASTRIC ULCERS
81MG;40MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 DISCN TABLET, DELAYED RELEASE ORAL 6926907 Feb. 28, 2023 TREATMENT OR SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE, CARDIOVASCULAR EVENTS, OR CEREBROVASCULAR EVENTS AND RISK-REDUCTION OF ASPIRIN-ASSOCIATED GASTRIC ULCERS
81MG;40MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 DISCN TABLET, DELAYED RELEASE ORAL 8206741 Feb. 28, 2023 TREATMENT OR SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE, CARDIOVASCULAR EVENTS, OR CEREBROVASCULAR EVENTS AND RISK-REDUCTION OF ASPIRIN-ASSOCIATED GASTRIC ULCERS
325MG VAZALORE PLX PHARMA N203697 Jan. 14, 2013 OTC CAPSULE ORAL 9226892 Sept. 29, 2032 TEMPORARY REDUCTION OF FEVER
325MG VAZALORE PLX PHARMA N203697 Jan. 14, 2013 OTC CAPSULE ORAL 9226892 Sept. 29, 2032 TEMPORARY RELIEF OF MINOR ACHES AND PAINS
325MG VAZALORE PLX PHARMA N203697 Jan. 14, 2013 OTC CAPSULE ORAL 9226892 Sept. 29, 2032 TREATMENT/PREVENTION OF CARDIOVASCULAR DISEASE
325MG;40MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 DISCN TABLET, DELAYED RELEASE ORAL 9987231 Jan. 2, 2033 FOR SECONDARY PREVENTION OF CARDIOVASCULAR AND CEREBROVASCULAR EVENTS IN PATIENTS AT RISK OF DEVELOPING ASPIRIN-ASSOCIATED GASTRIC ULCERS
81MG;40MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 DISCN TABLET, DELAYED RELEASE ORAL 9987231 Jan. 2, 2033 FOR SECONDARY PREVENTION OF CARDIOVASCULAR AND CEREBROVASCULAR EVENTS IN PATIENTS AT RISK OF DEVELOPING ASPIRIN-ASSOCIATED GASTRIC ULCERS
325MG;40MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 DISCN TABLET, DELAYED RELEASE ORAL 9539214 March 13, 2033 TREATMENT OR SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE, CARDIOVASCULAR EVENTS, OR CEREBROVASCULAR EVENTS AND RISK-REDUCTION OF ASPIRIN-ASSOCIATED GASTRIC ULCERS
81MG;40MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 DISCN TABLET, DELAYED RELEASE ORAL 9539214 March 13, 2033 TREATMENT OR SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE, CARDIOVASCULAR EVENTS, OR CEREBROVASCULAR EVENTS AND RISK-REDUCTION OF ASPIRIN-ASSOCIATED GASTRIC ULCERS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 5.12 WOMBAT-PK CHEMBL
Prostaglandin G/H synthase 1 Enzyme INHIBITOR IC50 5.77 WOMBAT-PK CHEMBL
Gamma-glutamyltranspeptidase 1 Enzyme IC50 4.44 CHEMBL
Nicotinate phosphoribosyltransferase Enzyme Ki 9.30 CHEMBL
Acid-sensing ion channel 3 Ion channel BLOCKER IC50 4 IUPHAR
Prostaglandin G/H synthase 1 Enzyme IC50 6.52 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 5.62 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 6.46 CHEMBL
Acidic phospholipase A2 3 Enzyme Kd 5.20 WOMBAT-PK

External reference:

IDSource
4017536 VUID
N0000145918 NUI
D00109 KEGG_DRUG
1191 RXNORM
C0004057 UMLSCUI
CHEBI:15365 CHEBI
AIN PDB_CHEM_ID
CHEMBL25 ChEMBL_ID
DB00945 DRUGBANK_ID
2244 PUBCHEM_CID
4139 IUPHAR_LIGAND_ID
493-53-8 SECONDARY_CAS_RN
132-49-0 SECONDARY_CAS_RN
25817-25-8 SECONDARY_CAS_RN
69-46-5 SECONDARY_CAS_RN
1466-82-6 SECONDARY_CAS_RN
37933-78-1 SECONDARY_CAS_RN
R16CO5Y76E UNII
244 MMSL
34512 MMSL
4223 MMSL
d00170 MMSL
001587 NDDF
4017536 VANDF
D001241 MESH_DESCRIPTOR_UI
387458008 SNOMEDCT_US
7947003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Fiorinal with Codeine HUMAN PRESCRIPTION DRUG LABEL 4 0023-6010 CAPSULE 325 mg ORAL NDA 36 sections
Fiorinal HUMAN PRESCRIPTION DRUG LABEL 3 0023-6146 CAPSULE 325 mg ORAL NDA 23 sections
ExcedrinExtra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-2000 TABLET, FILM COATED 250 mg ORAL OTC monograph not final 13 sections
ExcedrinExtra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-2001 TABLET, FILM COATED 250 mg ORAL OTC monograph not final 15 sections
ExcedrinExtra Strength Geltabs HUMAN OTC DRUG LABEL 3 0067-2021 TABLET, COATED 250 mg ORAL OTC monograph not final 14 sections
ExcedrinMigraine Geltabs HUMAN OTC DRUG LABEL 3 0067-2035 TABLET, COATED 250 mg ORAL NDA 14 sections
EXCEDRINMIGRAINE HUMAN OTC DRUG LABEL 3 0067-2039 TABLET, FILM COATED 250 mg ORAL NDA 15 sections
ExcedrinMigraine HUMAN OTC DRUG LABEL 3 0067-2040 TABLET, FILM COATED 250 mg ORAL NDA 16 sections
Excedrin PM Triple Action Caplets HUMAN OTC DRUG LABEL 3 0067-2056 TABLET, COATED 250 mg ORAL OTC monograph not final 16 sections
EXCEDRINMIGRAINE HUMAN OTC DRUG LABEL 3 0067-8201 TABLET, FILM COATED 250 mg ORAL NDA 15 sections
ExcedrinExtra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-8202 TABLET, FILM COATED 250 mg ORAL OTC monograph not final 15 sections
ExcedrinExtra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-8203 TABLET, FILM COATED 250 mg ORAL OTC monograph not final 15 sections
good sense aspirin HUMAN OTC DRUG LABEL 1 0113-0259 TABLET, CHEWABLE 81 mg ORAL OTC monograph not final 15 sections
Good Sense aspirin HUMAN OTC DRUG LABEL 1 0113-0274 TABLET, CHEWABLE 81 mg ORAL OTC monograph not final 15 sections
good sense migraine formula HUMAN OTC DRUG LABEL 3 0113-0374 TABLET, FILM COATED 250 mg ORAL ANDA 15 sections
good sense aspirin HUMAN OTC DRUG LABEL 1 0113-0416 TABLET, FILM COATED 325 mg ORAL OTC monograph not final 15 sections
good sense aspirin HUMAN OTC DRUG LABEL 1 0113-0467 TABLET, CHEWABLE 81 mg ORAL OTC monograph not final 15 sections
Basic Care Aspirin HUMAN OTC DRUG LABEL 1 0113-0773 TABLET, FILM COATED 325 mg ORAL OTC monograph not final 15 sections
good sense headache relief HUMAN OTC DRUG LABEL 3 0113-1855 TABLET, FILM COATED 250 mg ORAL OTC monograph not final 15 sections
Good Sense Aspirin HUMAN OTC DRUG LABEL 1 0113-1919 TABLET, FILM COATED 325 mg ORAL OTC monograph not final 14 sections
basic care migraine relief HUMAN OTC DRUG LABEL 3 0113-7374 TABLET, FILM COATED 250 mg ORAL ANDA 15 sections
basic care aspirin HUMAN OTC DRUG LABEL 1 0113-7467 TABLET, CHEWABLE 81 mg ORAL OTC monograph not final 15 sections
Alka-Seltzer Plus Severe Cold PowerFast FizzOrange Zest HUMAN OTC DRUG LABEL 3 0280-0020 TABLET, EFFERVESCENT 325 mg ORAL OTC monograph final 17 sections
Alka-Seltzer Plus Severe Cold Powerfast Fizz Night HUMAN OTC DRUG LABEL 4 0280-0021 TABLET, EFFERVESCENT 500 mg ORAL OTC monograph final 16 sections
Alka-Seltzer Plus Severe Cold and Cough PowerFast Fizz HUMAN OTC DRUG LABEL 4 0280-0023 TABLET, EFFERVESCENT 325 mg ORAL OTC monograph final 16 sections
Alka-Seltzer Plus Severe Cold PowerFast Fizz Non Drowsy HUMAN OTC DRUG LABEL 3 0280-0024 TABLET, EFFERVESCENT 325 mg ORAL OTC monograph final 16 sections
BAYER 500 mg HUMAN OTC DRUG LABEL 1 0280-0029 POWDER 500 mg ORAL Export only 2 sections
Alka-Seltzer Plus Cold Sparkling Original PowerFast Fizz HUMAN OTC DRUG LABEL 3 0280-0060 TABLET, EFFERVESCENT 325 mg ORAL OTC monograph final 15 sections
Bayer Headache HUMAN OTC DRUG LABEL 2 0280-0064 TABLET 500 mg ORAL OTC monograph not final 14 sections
Alka-Seltzer Plus Severe Cold Night PowerFast Fizz HUMAN OTC DRUG LABEL 4 0280-0068 TABLET, EFFERVESCENT 325 mg ORAL OTC monograph final 16 sections