acetylsalicylic acid Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
74 50-78-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • acetylsalisylic acid
  • aspirin
  • acetylsalicylic acid
  • aspirin sodium
  • aspirin magnesium
  • aspirin potassium
  • aspirin calcium
  • aspirin anhydride
  • aspirin lysine
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
  • Molecular weight: 180.16
  • Formula: C9H8O4
  • CLOGP: 1.02
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 63.60
  • ALOGS: -2.09
  • ROTB: 3

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1 tablet O
30 mg O
3 g O
1 g P
3 g R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1.40 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 370.22 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.22 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 12 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.68 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.26 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
April 12, 1950 FDA ENDO PHARMS
Jan. 1, 1898 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 1134.62 11.09 6175 729202 671663 45279022
Gastrointestinal haemorrhage 998.46 11.09 3082 732295 74291 45876394
Myocardial infarction 794.78 11.09 3343 732034 94185 45856500
Cerebrovascular accident 610.94 11.09 3175 732202 97864 45852821
Acute myocardial infarction 555.47 11.09 1418 733959 30506 45920179
Coronary artery disease 485.77 11.09 1398 733979 32354 45918331
Rheumatoid arthritis 482.49 11.09 2045 733332 238170 45712515
Labelled drug-drug interaction medication error 443.86 11.09 627 734750 8434 45942251
Cardiac failure congestive 404.74 11.09 2653 732724 89097 45861588
Treatment failure 380.48 11.09 547 734830 92540 45858145
Aspirin-exacerbated respiratory disease 372.50 11.09 198 735179 550 45950135
Device expulsion 331.97 11.09 27 735350 27515 45923170
Off label use 325.73 11.09 4127 731250 375714 45574971
Toxicity to various agents 318.24 11.09 4891 730486 206875 45743810
Angina pectoris 292.27 11.09 1008 734369 25767 45924918
Melaena 279.51 11.09 1018 734359 26754 45923931
Completed suicide 267.07 11.09 3490 731887 142430 45808255
Injection site pain 262.86 11.09 839 734538 106313 45844372
Pemphigus 255.25 11.09 203 735174 45071 45905614
Alopecia 250.81 11.09 1514 733863 160900 45789785
Transient ischaemic attack 244.31 11.09 1144 734233 33759 45916926
Upper gastrointestinal haemorrhage 224.27 11.09 676 734701 16062 45934623
Systemic lupus erythematosus 223.57 11.09 429 734948 64751 45885934
Angina unstable 201.82 11.09 398 734979 7150 45943535
Vascular stent thrombosis 196.61 11.09 139 735238 732 45949953
Injection site erythema 195.18 11.09 565 734812 73862 45876823
Injection site reaction 189.74 11.09 287 735090 47562 45903123
Cerebral haemorrhage 187.03 11.09 914 734463 27457 45923228
Coronary arterial stent insertion 177.58 11.09 222 735155 2631 45948054
Malignant neoplasm progression 174.56 11.09 487 734890 64439 45886246
Febrile neutropenia 168.51 11.09 841 734536 93786 45856899
Rhabdomyolysis 162.22 11.09 1174 734203 40735 45909950
Lower gastrointestinal haemorrhage 160.69 11.09 356 735021 6964 45943721
Metabolic acidosis 158.64 11.09 1101 734276 37679 45913006
Atrial fibrillation 155.82 11.09 2394 732983 101196 45849489
Acute hepatic failure 155.26 11.09 548 734829 14173 45936512
Drug intolerance 154.29 11.09 1525 733852 145524 45805161
Psoriatic arthropathy 152.31 11.09 210 735167 36169 45914516
Haematoma 145.52 11.09 930 734447 30942 45919743
Pain 145.08 11.09 6092 729285 470856 45479829
Psoriasis 143.17 11.09 693 734684 77911 45872774
Therapeutic product effect incomplete 140.05 11.09 693 734684 77460 45873225
Syncope 132.82 11.09 2355 733022 102448 45848237
Rectal haemorrhage 131.94 11.09 1043 734334 37212 45913473
Coagulopathy 131.39 11.09 609 734768 17890 45932795
Synovitis 131.06 11.09 506 734871 60569 45890116
Glossodynia 128.26 11.09 321 735056 44052 45906633
Haematemesis 126.29 11.09 832 734545 27974 45922711
Angioedema 126.16 11.09 1055 734322 38287 45912398
Haemoglobin decreased 124.03 11.09 2780 732597 126169 45824516
Coronary artery occlusion 123.77 11.09 343 735034 7759 45942926
Hypotension 123.39 11.09 4652 730725 227937 45722748
Condition aggravated 122.33 11.09 2932 732445 242120 45708565
Coronary artery bypass 119.46 11.09 169 735208 2276 45948409
Injection site pruritus 119.21 11.09 282 735095 39461 45911224
Chest pain 119.18 11.09 3628 731749 172696 45777989
Injection site swelling 114.80 11.09 294 735083 40033 45910652
Myocardial ischaemia 113.94 11.09 450 734927 12299 45938386
Contraindicated product administered 113.66 11.09 764 734613 79183 45871502
Suicidal ideation 112.87 11.09 480 734897 55902 45894783
Hypoglycaemia 112.63 11.09 1331 734046 53018 45897667
Exposure to toxic agent 111.68 11.09 148 735229 1866 45948819
Blood loss anaemia 110.33 11.09 341 735036 8216 45942469
Mucosal inflammation 108.77 11.09 287 735090 38689 45911996
Anion gap 107.37 11.09 107 735270 966 45949719
Disease progression 107.32 11.09 920 734457 90380 45860305
Wrong technique in product usage process 105.48 11.09 469 734908 53953 45896732
Product use issue 105.40 11.09 967 734410 93677 45857008
No adverse event 104.18 11.09 241 735136 33990 45916695
Thrombosis in device 102.28 11.09 175 735202 2804 45947881
Haematochezia 101.99 11.09 970 734407 36523 45914162
Acute coronary syndrome 100.93 11.09 372 735005 9832 45940853
Duodenal ulcer 99.99 11.09 295 735082 6923 45943762
Gastric ulcer 99.21 11.09 637 734740 21226 45929459
Neutropenia 99.03 11.09 1622 733755 141582 45809103
Coronary artery stenosis 98.74 11.09 225 735152 4488 45946197
Hospitalisation 98.69 11.09 589 734788 62796 45887889
Haemorrhage intracranial 96.42 11.09 427 734950 12297 45938388
Abdominal discomfort 95.89 11.09 1739 733638 149426 45801259
Hand deformity 95.41 11.09 256 735121 34318 45916367
Pregnancy 94.43 11.09 177 735200 26960 45923725
Fall 90.10 11.09 6176 729201 322921 45627764
Vascular pseudoaneurysm 88.49 11.09 109 735268 1271 45949414
Infective pulmonary exacerbation of cystic fibrosis 88.16 11.09 30 735347 10777 45939908
Subdural haematoma 86.57 11.09 420 734957 12577 45938108
Arthralgia 85.76 11.09 4783 730594 359820 45590865
Pyrexia 84.57 11.09 4562 730815 344240 45606445
Infection 84.35 11.09 1538 733839 132054 45818631
Acute kidney injury 83.14 11.09 4526 730851 231329 45719356
Blood pressure fluctuation 82.45 11.09 787 734590 29661 45921024
Vascular stent stenosis 82.19 11.09 69 735308 487 45950198
Product administration error 80.61 11.09 559 734818 19122 45931563
International normalised ratio increased 80.11 11.09 1108 734269 45775 45904910
Abortion spontaneous 79.33 11.09 385 734992 43261 45907424
Anaemia 79.15 11.09 4851 730526 250928 45699757
Intentional product misuse 77.79 11.09 1107 734270 46021 45904664
Intentional self-injury 77.75 11.09 165 735212 24001 45926684
Bradycardia 75.34 11.09 1465 733912 64833 45885852
Drug resistance 74.99 11.09 98 735279 17270 45933415
Cerebral infarction 74.05 11.09 625 734752 22741 45927944
Drug abuse 74.02 11.09 640 734737 62768 45887917
Device dislocation 72.56 11.09 146 735231 21656 45929029
Gastritis erosive 72.09 11.09 216 735161 5114 45945571
Rash 71.96 11.09 4744 730633 351768 45598917
Cytomegalovirus infection 71.75 11.09 109 735268 18035 45932650
Swelling 71.40 11.09 1457 733920 123054 45827631
Loss of personal independence in daily activities 70.91 11.09 568 734809 56615 45894070
Gastric ulcer haemorrhage 70.36 11.09 202 735175 4666 45946019
Arthropathy 70.11 11.09 926 734451 83774 45866911
Coronary artery thrombosis 69.88 11.09 89 735288 1076 45949609
Carotid artery stenosis 69.73 11.09 208 735169 4912 45945773
Asthma 69.64 11.09 1018 734359 90524 45860161
Accidental exposure to product 69.46 11.09 142 735235 20939 45929746
Haemorrhage 68.41 11.09 1230 734147 53639 45897046
Epistaxis 68.41 11.09 1407 733970 62898 45887787
Product use in unapproved indication 68.29 11.09 1005 734372 89268 45861417
Device issue 68.05 11.09 132 735245 19848 45930837
Full blood count decreased 67.19 11.09 588 734789 21623 45929062
Deafness transitory 67.07 11.09 104 735273 1528 45949157
Diverticulum intestinal haemorrhagic 66.86 11.09 90 735287 1153 45949532
Internal haemorrhage 66.47 11.09 187 735190 4268 45946417
Musculoskeletal stiffness 65.07 11.09 1118 734259 96875 45853810
Retroperitoneal haemorrhage 64.76 11.09 137 735240 2593 45948092
Product dose omission issue 64.29 11.09 2093 733284 166427 45784258
Pericardial haemorrhage 63.96 11.09 99 735278 1452 45949233
Haemorrhagic stroke 63.76 11.09 213 735164 5353 45945332
Device difficult to use 62.27 11.09 24 735353 7980 45942705
Product quality issue 62.18 11.09 319 735058 35329 45915356
Retroperitoneal haematoma 62.06 11.09 132 735245 2508 45948177
Palmar-plantar erythrodysaesthesia syndrome 61.41 11.09 145 735232 20306 45930379
Seizure 61.09 11.09 1473 733904 121581 45829104
Thrombosis 61.02 11.09 1231 734146 54838 45895847
Medication error 60.96 11.09 750 734627 30161 45920524
Overdose 60.41 11.09 2066 733311 99913 45850772
Therapeutic product effect decreased 59.93 11.09 927 734450 81674 45869011
Duodenal ulcer haemorrhage 59.64 11.09 123 735254 2285 45948400
Therapeutic response decreased 59.47 11.09 416 734961 42729 45907956
C-reactive protein abnormal 59.05 11.09 157 735220 21113 45929572
Metastases to bone 59.05 11.09 116 735261 17360 45933325
Blood pressure increased 59.02 11.09 2499 732878 124167 45826518
Exposure during pregnancy 58.88 11.09 1277 734100 106935 45843750
Ischaemic stroke 58.79 11.09 458 734919 16264 45934421
Arteriosclerosis 58.12 11.09 305 735072 9428 45941257
Neoplasm progression 57.91 11.09 220 735157 26463 45924222
Bone marrow failure 57.29 11.09 256 735121 29413 45921272
Neurotoxicity 56.59 11.09 80 735297 13637 45937048
Subarachnoid haemorrhage 56.29 11.09 334 735043 10819 45939866
Acute myeloid leukaemia 55.70 11.09 102 735275 15676 45935009
Hypertensive emergency 55.49 11.09 95 735282 1523 45949162
Confusional state 55.22 11.09 3063 732314 156829 45793856
Extradural haematoma 54.77 11.09 88 735289 1335 45949350
Pneumocystis jirovecii pneumonia 54.34 11.09 98 735279 15150 45935535
Sinus bradycardia 53.26 11.09 386 734991 13396 45937289
Asthenia 53.22 11.09 5637 729740 305438 45645247
Arteriosclerosis coronary artery 53.20 11.09 262 735115 7894 45942791
Mood swings 53.09 11.09 110 735267 16142 45934543
Drug hypersensitivity 53.00 11.09 3222 732155 240603 45710082
Uterine perforation 52.98 11.09 24 735353 7243 45943442
Haemorrhagic arteriovenous malformation 52.97 11.09 32 735345 122 45950563
Haemorrhagic transformation stroke 52.97 11.09 78 735299 1092 45949593
Spinal epidural haematoma 51.76 11.09 63 735314 725 45949960
Unintentional medical device removal 50.83 11.09 6 735371 4547 45946138
Lacunar infarction 50.74 11.09 145 735232 3340 45947345
Injection site warmth 50.45 11.09 87 735290 13685 45937000
Drug interaction 49.72 11.09 3778 731599 199316 45751369
Metastases to liver 49.63 11.09 151 735226 19434 45931251
Shock haemorrhagic 49.28 11.09 267 735110 8357 45942328
Leukopenia 49.23 11.09 768 734609 67575 45883110
Hepatotoxicity 48.54 11.09 605 734772 24404 45926281
Transplant dysfunction 47.98 11.09 8 735369 4674 45946011
Febrile bone marrow aplasia 47.98 11.09 24 735353 6838 45943847
Multiple sclerosis relapse 47.47 11.09 429 734948 41696 45908989
Plasma cell myeloma 47.23 11.09 973 734404 43505 45907180
Injection site rash 46.78 11.09 113 735264 15700 45934985
Heart rate decreased 46.44 11.09 730 734647 30993 45919692
Hemiparesis 46.31 11.09 502 734875 19567 45931118
Abdominal wall haematoma 46.03 11.09 124 735253 2757 45947928
Unintended pregnancy 45.67 11.09 16 735361 5644 45945041
Faeces discoloured 45.49 11.09 434 734943 16353 45934332
Neurologic neglect syndrome 45.31 11.09 55 735322 631 45950054
Device use error 45.27 11.09 12 735365 5069 45945616
Vascular graft 45.15 11.09 59 735318 733 45949952
Surgery 45.04 11.09 267 735110 28518 45922167
Dizziness 45.02 11.09 6069 729308 334345 45616340
Coronary artery restenosis 44.34 11.09 44 735333 395 45950290
Interstitial lung disease 44.20 11.09 591 734786 53358 45897327
Post procedural haematoma 43.31 11.09 77 735300 1274 45949411
Amenorrhoea 42.88 11.09 46 735331 8849 45941836
Drug withdrawal syndrome 42.85 11.09 254 735123 27130 45923555
Ascites 42.80 11.09 369 735008 36215 45914470
Epstein-Barr virus infection 42.72 11.09 27 735350 6757 45943928
Arterial stenosis 42.68 11.09 52 735325 599 45950086
Peripheral arterial occlusive disease 42.46 11.09 143 735234 3609 45947076
Peripheral ischaemia 42.43 11.09 163 735214 4396 45946289
Neuroleptic malignant syndrome 41.91 11.09 69 735308 11053 45939632
Joint swelling 41.83 11.09 2163 733214 163910 45786775
Haematotoxicity 41.76 11.09 29 735348 6904 45943781
Premature delivery 41.60 11.09 531 734846 21538 45929147
Hypersensitivity 41.33 11.09 1940 733437 148381 45802304
Gastrointestinal vascular malformation haemorrhagic 41.31 11.09 28 735349 136 45950549
Knee arthroplasty 41.14 11.09 212 735165 23453 45927232
Mitral valve incompetence 40.96 11.09 466 734911 18386 45932299
Breast cancer 40.88 11.09 489 734888 45029 45905656
Post procedural haemorrhage 40.49 11.09 227 735150 7199 45943486
Haemophagocytic lymphohistiocytosis 40.37 11.09 43 735334 8299 45942386
Granuloma skin 40.20 11.09 4 735373 3466 45947219
Intraventricular haemorrhage 39.97 11.09 91 735286 1814 45948871
Carotid artery thrombosis 39.49 11.09 53 735324 677 45950008
Device malfunction 39.22 11.09 96 735281 13278 45937407
Acute graft versus host disease 38.91 11.09 8 735369 4022 45946663
Myopathy 38.61 11.09 256 735121 8625 45942060
Hemiplegia 38.44 11.09 213 735164 6725 45943960
Heart rate irregular 38.37 11.09 455 734922 18136 45932549
Ankylosing spondylitis 38.22 11.09 30 735347 6707 45943978
Graft versus host disease 37.80 11.09 29 735348 6559 45944126
Cardiac disorder 37.65 11.09 931 734446 42927 45907758
Pregnancy with contraceptive device 37.61 11.09 12 735365 4491 45946194
Ecchymosis 37.36 11.09 290 735087 10286 45940399
Ischaemia 37.02 11.09 153 735224 4271 45946414
Hip arthroplasty 36.97 11.09 153 735224 17959 45932726
Pathogen resistance 36.96 11.09 25 735352 6035 45944650
Metastases to central nervous system 36.61 11.09 76 735301 11145 45939540
Pancytopenia 36.43 11.09 1040 734337 84018 45866667
Metastases to lung 36.13 11.09 71 735306 10625 45940060
Pyroglutamate increased 36.12 11.09 39 735338 390 45950295
Haematuria 35.95 11.09 609 734768 26249 45924436
Orthostatic hypotension 35.93 11.09 567 734810 24091 45926594
Posterior reversible encephalopathy syndrome 35.40 11.09 121 735256 15020 45935665
Injection site urticaria 35.02 11.09 86 735291 11881 45938804
Hyperprolactinaemia 34.98 11.09 3 735374 2929 45947756
Rheumatoid nodule 34.89 11.09 55 735322 8965 45941720
Abortion incomplete 34.76 11.09 5 735372 3259 45947426
Stent placement 34.63 11.09 129 735248 3427 45947258
Contusion 34.63 11.09 1698 733679 85789 45864896
Colitis microscopic 34.16 11.09 198 735179 6358 45944327
Gastric haemorrhage 34.10 11.09 184 735193 5750 45944935
Ovarian cyst 34.02 11.09 111 735266 13976 45936709
Acute lung injury 33.95 11.09 67 735310 1204 45949481
Complication of device insertion 33.51 11.09 18 735359 4926 45945759
Migraine 33.43 11.09 843 734534 69183 45881502
Sinus node dysfunction 33.31 11.09 145 735232 4144 45946541
Sepsis 33.20 11.09 1777 733600 134237 45816448
Drug dependence 33.08 11.09 181 735196 19720 45930965
Coronary artery aneurysm 33.04 11.09 14 735363 18 45950667
Hyponatraemia 32.79 11.09 1930 733447 99402 45851283
Withdrawal syndrome 32.34 11.09 161 735216 17973 45932712
Presyncope 32.19 11.09 553 734824 23901 45926784
Hypertension 32.09 11.09 3548 731829 192808 45757877
Gastrointestinal toxicity 32.05 11.09 14 735363 4317 45946368
Therapy interrupted 32.01 11.09 77 735300 10714 45939971
Joint stiffness 31.90 11.09 273 735104 26835 45923850
Anti-cyclic citrullinated peptide antibody positive 31.89 11.09 174 735203 18971 45931714
Irritability 31.66 11.09 297 735080 28649 45922036
Panniculitis 31.61 11.09 26 735351 5678 45945007
Oesophageal intramural haematoma 31.54 11.09 19 735358 72 45950613
Depression 31.48 11.09 2280 733097 167824 45782861
Mania 30.92 11.09 79 735298 10767 45939918
Therapy non-responder 30.80 11.09 459 734918 40693 45909992
Device breakage 30.49 11.09 67 735310 9625 45941060
Hyperkalaemia 30.43 11.09 1029 734348 49680 45901005
Subdural haemorrhage 30.36 11.09 108 735269 2804 45947881
Atrioventricular block 30.01 11.09 197 735180 6614 45944071
Large intestinal haemorrhage 29.97 11.09 60 735317 1090 45949595
Swollen tongue 29.90 11.09 636 734741 28596 45922089
Drug reaction with eosinophilia and systemic symptoms 29.87 11.09 309 735068 29239 45921446
Product storage error 29.82 11.09 91 735286 11701 45938984
Fear of injection 29.76 11.09 14 735363 4133 45946552
Intermittent claudication 29.75 11.09 79 735298 1741 45948944
Bronchopulmonary aspergillosis 29.67 11.09 45 735332 7451 45943234
Osteonecrosis of jaw 29.60 11.09 373 735004 34029 45916656
Juvenile idiopathic arthritis 29.57 11.09 14 735363 4118 45946567
Metastases to lymph nodes 29.05 11.09 37 735340 6594 45944091
Adverse event 28.90 11.09 372 735005 33812 45916873
Blood pressure systolic increased 28.70 11.09 624 734753 28163 45922522
Aspergillus infection 28.61 11.09 40 735337 6850 45943835
Cerebellar haemorrhage 28.46 11.09 64 735313 1265 45949420
Pharyngeal haemorrhage 28.39 11.09 39 735338 510 45950175
Injection site mass 28.30 11.09 131 735246 14909 45935776
Immune reconstitution inflammatory syndrome 28.28 11.09 29 735348 5696 45944989
Anion gap abnormal 28.27 11.09 31 735346 316 45950369
Sinus arrest 28.16 11.09 75 735302 1656 45949029
Product prescribing error 28.09 11.09 458 734919 19589 45931096
Human herpesvirus 6 infection 27.77 11.09 3 735374 2436 45948249
Blood creatine phosphokinase increased 27.65 11.09 601 734776 27123 45923562
Arterial haemorrhage 27.50 11.09 74 735303 1644 45949041
Product monitoring error 27.47 11.09 81 735296 1900 45948785
Acne 27.47 11.09 192 735185 19727 45930958
Prothrombin time prolonged 27.46 11.09 251 735126 9345 45941340
Ischaemic cardiomyopathy 27.38 11.09 97 735280 2513 45948172
Traumatic intracranial haemorrhage 27.27 11.09 30 735347 307 45950378
Incorrect route of product administration 27.23 11.09 149 735228 16234 45934451
Oesophagitis haemorrhagic 27.01 11.09 34 735343 406 45950279
Galactorrhoea 26.97 11.09 13 735364 3784 45946901
Maternal exposure during pregnancy 26.88 11.09 1330 734047 101219 45849466
Atrioventricular block complete 26.87 11.09 209 735168 7418 45943267
Disability 26.77 11.09 77 735300 10090 45940595
Graft versus host disease in skin 26.73 11.09 3 735374 2364 45948321
Aortic stenosis 26.63 11.09 138 735239 4244 45946441
Carotid arteriosclerosis 26.59 11.09 52 735325 928 45949757
Hepatocellular injury 26.57 11.09 317 735060 29205 45921480
Hepatic necrosis 26.53 11.09 165 735212 5436 45945249
Heparin-induced thrombocytopenia 26.40 11.09 136 735241 4173 45946512
Blood pressure diastolic decreased 26.39 11.09 341 735036 13870 45936815
Spinal cord haemorrhage 26.23 11.09 22 735355 155 45950530
Puncture site haemorrhage 26.17 11.09 27 735350 255 45950430
Small intestinal haemorrhage 26.00 11.09 78 735299 1848 45948837
Haematocrit decreased 25.99 11.09 730 734647 34327 45916358
Haemoptysis 25.89 11.09 567 734810 25622 45925063
Occult blood positive 25.70 11.09 118 735259 3452 45947233
Lactic acidosis 25.67 11.09 708 734669 33201 45917484
Thrombotic microangiopathy 25.65 11.09 58 735319 8248 45942437
Mucormycosis 25.64 11.09 3 735374 2289 45948396
Cystic fibrosis 25.63 11.09 13 735364 3675 45947010
Ear infection 25.61 11.09 507 734870 22506 45928179
Cataract 25.61 11.09 915 734462 44500 45906185
Second primary malignancy 25.60 11.09 40 735337 6544 45944141
Spontaneous haematoma 25.56 11.09 43 735334 679 45950006
Erythema 25.50 11.09 1920 733457 140900 45809785
Akathisia 25.38 11.09 52 735325 7662 45943023
Product substitution issue 25.37 11.09 136 735241 14895 45935790
Anxiety 25.23 11.09 2495 732882 179462 45771223
Peripheral vascular disorder 25.21 11.09 171 735206 5806 45944879
Menstruation irregular 25.17 11.09 40 735337 6499 45944186
Transplant rejection 25.03 11.09 73 735304 9523 45941162
Discomfort 25.00 11.09 552 734825 46118 45904567
Arterial occlusive disease 24.97 11.09 145 735232 4659 45946026
Multiple-drug resistance 24.96 11.09 5 735372 2560 45948125
Sleep disorder 24.92 11.09 554 734823 46241 45904444
Wound 24.76 11.09 500 734877 42302 45908383
Atrioventricular block second degree 24.75 11.09 122 735255 3677 45947008
Peripheral artery stenosis 24.70 11.09 36 735341 499 45950186
Carotid artery occlusion 24.69 11.09 95 735282 2564 45948121
Blood glucose increased 24.33 11.09 1377 734000 70636 45880049
Multiple injuries 24.04 11.09 77 735300 1892 45948793
Venoocclusive liver disease 24.03 11.09 19 735358 4232 45946453
Abortion early 23.97 11.09 10 735367 12 45950673
Anaphylactic shock 23.93 11.09 204 735173 20070 45930615
Blood iron abnormal 23.85 11.09 10 735367 3160 45947525
Oesophageal mucosal dissection 23.75 11.09 11 735366 20 45950665
Dystonia 23.66 11.09 94 735283 11163 45939522
Breast cancer metastatic 23.51 11.09 123 735254 13555 45937130
Cardiac arrest 23.49 11.09 1690 733687 88709 45861976
Colitis ulcerative 23.44 11.09 173 735204 17559 45933126
Device deployment issue 23.39 11.09 13 735364 3490 45947195
Brain herniation 23.32 11.09 102 735275 2921 45947764
Diverticulitis intestinal haemorrhagic 23.30 11.09 18 735359 111 45950574
Oedema peripheral 23.30 11.09 2865 732512 156841 45793844
Lung disorder 23.25 11.09 512 734865 42792 45907893
Labile hypertension 23.19 11.09 34 735343 474 45950211
Acute graft versus host disease in skin 23.10 11.09 9 735368 2973 45947712
Septic shock 23.01 11.09 715 734662 57178 45893507
Coronary artery dissection 22.99 11.09 40 735337 650 45950035
Stomatitis 22.84 11.09 862 734515 67435 45883250
Myelosuppression 22.82 11.09 55 735322 7648 45943037
Microcytic anaemia 22.75 11.09 103 735274 2995 45947690
Analgesic drug level increased 22.57 11.09 63 735314 1431 45949254
Diverticulum 22.57 11.09 273 735104 10933 45939752
Hepatic cirrhosis 22.51 11.09 150 735227 15582 45935103
Epilepsy 22.48 11.09 252 735125 23486 45927199
Device leakage 22.42 11.09 31 735346 5334 45945351
Sickle cell anaemia with crisis 22.37 11.09 18 735359 3974 45946711
Embedded device 22.26 11.09 9 735368 2907 45947778
Blood creatinine increased 22.26 11.09 1442 733935 74961 45875724
Depressed level of consciousness 22.24 11.09 939 734438 46630 45904055
Injection site bruising 22.23 11.09 411 734966 35225 45915460
Pulmonary tuberculosis 22.22 11.09 25 735352 4706 45945979
Complication associated with device 22.21 11.09 147 735230 15294 45935391
Troponin increased 22.14 11.09 204 735173 7612 45943073
Myoglobin blood increased 22.14 11.09 61 735316 1375 45949310
Cardiogenic shock 22.10 11.09 372 735005 16012 45934673
Post transplant lymphoproliferative disorder 22.09 11.09 17 735360 3839 45946846
Pulmonary renal syndrome 22.03 11.09 29 735348 363 45950322
Renal artery stenosis 21.90 11.09 70 735307 1718 45948967
Blood parathyroid hormone decreased 21.86 11.09 22 735355 4359 45946326
Hepatic ischaemia 21.86 11.09 33 735344 473 45950212
Gastrointestinal pain 21.84 11.09 196 735181 7259 45943426
Cytomegalovirus viraemia 21.76 11.09 23 735354 4455 45946230
Device related infection 21.70 11.09 219 735158 20822 45929863
Acidosis 21.55 11.09 270 735107 10904 45939781
Gastrointestinal ulcer haemorrhage 21.02 11.09 37 735340 607 45950078
Oesophageal haemorrhage 20.89 11.09 33 735344 493 45950192
Arthrodesis 20.84 11.09 5 735372 2259 45948426
Tuberculosis 20.77 11.09 87 735290 10178 45940507
Gastritis 20.72 11.09 698 734679 33680 45917005
Anion gap increased 20.71 11.09 61 735316 1430 45949255
Foetal exposure during pregnancy 20.65 11.09 350 735027 30397 45920288
Ventricular fibrillation 20.57 11.09 274 735103 11222 45939463
Acute lymphocytic leukaemia recurrent 20.56 11.09 4 735373 2091 45948594
Blood prolactin increased 20.55 11.09 11 735366 3016 45947669
Fibromyalgia 20.48 11.09 428 734949 36035 45914650
Ventricular hypertrophy 20.40 11.09 116 735261 3698 45946987
Ulcer haemorrhage 20.40 11.09 108 735269 3350 45947335
Drug eruption 20.37 11.09 226 735151 21103 45929582
Cerebrovascular disorder 20.35 11.09 95 735282 2799 45947886
Accidental overdose 20.33 11.09 436 734941 19630 45931055
Gestational diabetes 20.26 11.09 53 735324 7166 45943519
Hypochromic anaemia 20.21 11.09 59 735318 1376 45949309
Haemothorax 20.19 11.09 74 735303 1950 45948735
Abortion induced 20.12 11.09 88 735289 10172 45940513
Normochromic normocytic anaemia 20.10 11.09 130 735247 4342 45946343
Dilatation atrial 19.98 11.09 77 735300 2080 45948605
Blood urea increased 19.95 11.09 532 734845 24820 45925865
Blood creatine phosphokinase MB increased 19.87 11.09 54 735323 1207 45949478
Creatinine renal clearance decreased 19.80 11.09 181 735196 6739 45943946
Bundle branch block left 19.66 11.09 170 735207 6229 45944456
Bleeding time prolonged 19.61 11.09 35 735342 581 45950104
Cerebral haematoma 19.50 11.09 104 735273 3235 45947450
Tricuspid valve incompetence 19.45 11.09 314 735063 13403 45937282
Cerebral ischaemia 19.41 11.09 168 735209 6157 45944528
Labile blood pressure 19.36 11.09 65 735312 1638 45949047
Grip strength decreased 19.30 11.09 70 735307 8536 45942149
Injection site induration 19.27 11.09 64 735313 8015 45942670
Traumatic haemorrhage 19.27 11.09 28 735349 387 45950298
Complication of device removal 19.23 11.09 16 735361 3474 45947211
HELLP syndrome 19.17 11.09 44 735333 882 45949803
Arthritis 19.06 11.09 1009 734368 76307 45874378
Forced expiratory volume decreased 18.92 11.09 32 735345 5072 45945613
Nonreassuring foetal heart rate pattern 18.90 11.09 9 735368 18 45950667
Nausea 18.87 11.09 10200 725177 677254 45273431
Atrioventricular block first degree 18.83 11.09 164 735213 6022 45944663
Procedural pain 18.69 11.09 126 735251 13053 45937632
Blood glucose decreased 18.66 11.09 409 734968 18483 45932202
Electrocardiogram ST segment depression 18.64 11.09 88 735289 2605 45948080
Lymphadenopathy 18.54 11.09 394 734983 33094 45917591
Osteoporosis 18.54 11.09 492 734885 40116 45910569
Essential thrombocythaemia 18.53 11.09 17 735360 137 45950548
Death 18.49 11.09 4851 730526 330697 45619988
Pallor 18.48 11.09 487 734890 22679 45928006
Foetal placental thrombosis 18.39 11.09 12 735365 54 45950631
Hallucination, auditory 18.33 11.09 97 735280 10659 45940026
Foetal exposure timing unspecified 18.29 11.09 19 735358 181 45950504
Gastrointestinal angiodysplasia 18.27 11.09 28 735349 407 45950278
Adjustment disorder 18.27 11.09 56 735321 1343 45949342
Ocular retrobulbar haemorrhage 18.20 11.09 11 735366 42 45950643
Adenovirus infection 18.19 11.09 11 735366 2819 45947866
Thalamus haemorrhage 18.18 11.09 32 735345 525 45950160
Hypophagia 18.17 11.09 597 734780 28709 45921976
Chronic obstructive pulmonary disease 18.12 11.09 1095 734282 56538 45894147
Ectopic pregnancy 18.10 11.09 9 735368 2573 45948112
Coronary angioplasty 18.07 11.09 15 735362 104 45950581
Liver injury 17.97 11.09 353 735024 15648 45935037
Lymphoproliferative disorder 17.96 11.09 10 735367 2682 45948003
Cardiac tamponade 17.94 11.09 126 735251 4328 45946357
Colitis ischaemic 17.93 11.09 241 735136 9891 45940794
Device inappropriate shock delivery 17.93 11.09 7 735370 6 45950679
Implant site pain 17.92 11.09 6 735371 2178 45948507
Diffuse large B-cell lymphoma 17.91 11.09 42 735335 5896 45944789
Viral mutation identified 17.87 11.09 4 735373 1895 45948790
Extremity contracture 17.83 11.09 50 735327 1139 45949546
Myalgia 17.80 11.09 2207 733170 120881 45829804
Status epilepticus 17.72 11.09 138 735239 13841 45936844
Graft versus host disease in gastrointestinal tract 17.71 11.09 9 735368 2541 45948144
Head injury 17.70 11.09 511 734866 24125 45926560
Hypothermia 17.69 11.09 280 735097 11903 45938782
Body height decreased 17.67 11.09 231 735146 9421 45941264
Disturbance in social behaviour 17.65 11.09 3 735374 1728 45948957
Mood altered 17.63 11.09 126 735251 12881 45937804
Platelet function test abnormal 17.49 11.09 13 735364 75 45950610
Ischaemic cerebral infarction 17.36 11.09 51 735326 1194 45949491
Activated partial thromboplastin time prolonged 17.15 11.09 175 735202 6714 45943971
Spinal subdural haematoma 17.12 11.09 15 735362 113 45950572
Dehydration 17.07 11.09 2811 732566 156729 45793956
Intracranial aneurysm 17.05 11.09 97 735280 3093 45947592
Mediastinal haematoma 16.85 11.09 13 735364 80 45950605
Carotid artery disease 16.81 11.09 62 735315 1639 45949046
Traumatic liver injury 16.80 11.09 22 735355 274 45950411
Laboratory test abnormal 16.72 11.09 475 734902 22372 45928313
Muscle haemorrhage 16.71 11.09 99 735278 3205 45947480
Psychotic disorder 16.69 11.09 253 735124 22368 45928317
Varicella zoster virus infection 16.68 11.09 8 735369 2335 45948350
Drug dose omission by device 16.64 11.09 4 735373 1805 45948880
Iron deficiency anaemia 16.52 11.09 371 735006 16835 45933850
Embolic stroke 16.49 11.09 106 735271 3533 45947152
Electrocardiogram T wave abnormal 16.48 11.09 77 735300 2269 45948416
Neutropenic sepsis 16.41 11.09 120 735257 12204 45938481
Subcutaneous haematoma 16.37 11.09 59 735318 1542 45949143
Electrocardiogram ST segment elevation 16.36 11.09 107 735270 3588 45947097
Small intestinal ulcer haemorrhage 16.14 11.09 11 735366 54 45950631
Rash papulosquamous 16.13 11.09 13 735364 86 45950599
Periorbital oedema 16.12 11.09 135 735242 4900 45945785
Rheumatoid factor positive 16.09 11.09 226 735151 20235 45930450
Crystal urine present 16.07 11.09 50 735327 1209 45949476
Vessel puncture site haematoma 16.06 11.09 15 735362 124 45950561
Metastases to peritoneum 16.05 11.09 11 735366 2637 45948048
Percutaneous coronary intervention 16.01 11.09 16 735361 145 45950540
Left ventricular hypertrophy 15.85 11.09 133 735244 4830 45945855
Product adhesion issue 15.80 11.09 34 735343 4921 45945764
Tongue haematoma 15.78 11.09 12 735365 72 45950613
Haemorrhagic erosive gastritis 15.72 11.09 21 735356 267 45950418
Balance disorder 15.71 11.09 1200 734177 63321 45887364
Brain contusion 15.70 11.09 30 735347 526 45950159
Paronychia 15.69 11.09 30 735347 4536 45946149
Periorbital haematoma 15.67 11.09 37 735340 756 45949929
Neoplasm malignant 15.61 11.09 268 735109 23231 45927454
Fungal infection 15.57 11.09 350 735027 29170 45921515
Electric shock 15.47 11.09 40 735337 867 45949818
Catatonia 15.46 11.09 22 735355 3740 45946945
Hip fracture 15.45 11.09 537 734840 26019 45924666
Pelvic pain 15.43 11.09 113 735264 11489 45939196
Ventricular tachycardia 15.41 11.09 363 735014 16604 45934081
Product preparation error 15.27 11.09 25 735352 4014 45946671
Left-to-right cardiac shunt 15.24 11.09 14 735363 113 45950572
Arterial injury 15.20 11.09 16 735361 155 45950530
Rectourethral fistula 15.16 11.09 9 735368 33 45950652
Bezoar 15.11 11.09 53 735324 1366 45949319
Metastasis 15.11 11.09 28 735349 4284 45946401
Hepatitis C 15.10 11.09 50 735327 6268 45944417
Diabetic retinopathy 15.05 11.09 74 735303 2228 45948457
Multiple allergies 15.03 11.09 180 735197 7191 45943494
Alcohol interaction 15.03 11.09 10 735367 2435 45948250
Genital haemorrhage 14.99 11.09 53 735324 6513 45944172
Deafness 14.97 11.09 345 735032 15723 45934962
Subchorionic haematoma 14.96 11.09 14 735363 116 45950569
Ageusia 14.94 11.09 259 735118 11213 45939472
Reye's syndrome 14.94 11.09 6 735371 6 45950679
Osmolar gap 14.83 11.09 13 735364 98 45950587
Unresponsive to stimuli 14.79 11.09 634 734743 31540 45919145
Blood pressure diastolic abnormal 14.78 11.09 158 735219 6136 45944549
Cerebrovascular stenosis 14.77 11.09 9 735368 35 45950650
Sinus arrhythmia 14.66 11.09 51 735326 1309 45949376
Aplasia 14.61 11.09 21 735356 3555 45947130
Mental status changes 14.60 11.09 737 734640 37351 45913334
Brain stem haemorrhage 14.58 11.09 34 735343 689 45949996
Renal failure 14.56 11.09 2022 733355 111572 45839113
C-reactive protein increased 14.55 11.09 764 734613 57826 45892859
Aortic valve incompetence 14.55 11.09 151 735226 5819 45944866
Full blood count increased 14.48 11.09 39 735338 867 45949818
Nail ridging 14.48 11.09 18 735359 212 45950473
Haemorrhage urinary tract 14.45 11.09 34 735343 693 45949992
Urine abnormality 14.36 11.09 143 735234 5451 45945234
Pulmonary toxicity 14.31 11.09 33 735344 4660 45946025
Infusion site swelling 14.30 11.09 145 735232 5554 45945131
Lymphopenia 14.23 11.09 163 735214 15130 45935555
Iliac artery stenosis 14.22 11.09 9 735368 38 45950647
Dysphoria 14.21 11.09 32 735345 4557 45946128
Cerebral amyloid angiopathy 14.20 11.09 15 735362 146 45950539
Hypertensive heart disease 14.18 11.09 79 735298 2499 45948186
Disease recurrence 14.18 11.09 205 735172 18266 45932419
Aortic valve stenosis 14.16 11.09 91 735286 3033 45947652
Potentiating drug interaction 14.10 11.09 108 735269 3815 45946870
Angioplasty 14.08 11.09 48 735329 1219 45949466
Endometriosis 14.05 11.09 25 735352 3885 45946800
Wound haematoma 13.97 11.09 11 735366 70 45950615
Glycosylated haemoglobin increased 13.97 11.09 245 735132 10631 45940054
Lupus vasculitis 13.95 11.09 26 735351 447 45950238
Multiple sclerosis 13.92 11.09 291 735086 24500 45926185
Inflammation 13.90 11.09 627 734750 48154 45902531
Skin necrosis 13.89 11.09 79 735298 8525 45942160
Diverticulum intestinal 13.89 11.09 151 735226 5890 45944795
Mental disorder 13.87 11.09 259 735118 22166 45928519
Brain stem infarction 13.86 11.09 37 735340 818 45949867
Hand-eye coordination impaired 13.81 11.09 7 735370 17 45950668
Bipolar disorder 13.81 11.09 62 735315 7115 45943570
Cardiomegaly 13.80 11.09 367 735010 17115 45933570
Poisoning deliberate 13.78 11.09 71 735306 7855 45942830
Ventricular internal diameter abnormal 13.71 11.09 9 735368 41 45950644
Mouth haemorrhage 13.70 11.09 157 735220 6205 45944480
Tooth extraction 13.69 11.09 99 735278 10094 45940591
Peptic ulcer 13.69 11.09 108 735269 3850 45946835
Joint laxity 13.68 11.09 8 735369 2088 45948597
Blood pressure systolic abnormal 13.67 11.09 140 735237 5377 45945308
Constipation 13.66 11.09 3020 732357 171077 45779608
Jejunal ulcer 13.63 11.09 12 735365 91 45950594
Cardiac murmur 13.63 11.09 254 735123 11150 45939535
Aortic aneurysm 13.62 11.09 97 735280 3347 45947338
Blood creatine increased 13.61 11.09 121 735256 4469 45946216
Retinal haemorrhage 13.61 11.09 127 735250 4756 45945929
Platelet aggregation inhibition 13.60 11.09 13 735364 111 45950574
Femoral artery aneurysm 13.53 11.09 5 735372 3 45950682
Coronary artery dilatation 13.53 11.09 5 735372 3 45950682
Lip haematoma 13.53 11.09 5 735372 3 45950682
Joint destruction 13.53 11.09 17 735360 3047 45947638
Bradyarrhythmia 13.48 11.09 65 735312 1941 45948744
Vein collapse 13.41 11.09 28 735349 525 45950160
Blood pressure decreased 13.40 11.09 1060 734317 56099 45894586
Urinary straining 13.34 11.09 8 735369 30 45950655
Underdose 13.34 11.09 222 735155 19336 45931349
Brown-Sequard syndrome 13.27 11.09 6 735371 10 45950675
Bundle branch block right 13.26 11.09 125 735252 4694 45945991
Pulmonary function test decreased 13.21 11.09 25 735352 3795 45946890
PCO2 decreased 13.20 11.09 47 735330 1221 45949464
Renal haemorrhage 13.19 11.09 35 735342 771 45949914
Myositis 13.17 11.09 186 735191 7718 45942967
Shoulder arthroplasty 13.15 11.09 89 735288 3019 45947666
Aortic arteriosclerosis 13.15 11.09 143 735234 5578 45945107
Thrombotic thrombocytopenic purpura 13.14 11.09 106 735271 3804 45946881
Haemorrhoidal haemorrhage 13.14 11.09 102 735275 3618 45947067
Haemodialysis 13.07 11.09 211 735166 9006 45941679
Ductus arteriosus premature closure 13.05 11.09 21 735356 319 45950366
Cerebral hyperperfusion syndrome 13.03 11.09 7 735370 20 45950665
Dermatitis exfoliative generalised 13.01 11.09 17 735360 2996 45947689
Device kink 12.98 11.09 7 735370 1911 45948774
Drug dispensed to wrong patient 12.96 11.09 17 735360 212 45950473
Bone density decreased 12.96 11.09 95 735282 9657 45941028
Coronary artery insufficiency 12.96 11.09 12 735365 98 45950587
Cardiac failure 12.95 11.09 1444 733933 78504 45872181
Hypocapnia 12.92 11.09 22 735355 351 45950334
Wheezing 12.91 11.09 698 734679 52688 45897997
Vertebral artery stenosis 12.90 11.09 10 735367 62 45950623
Basal ganglia haemorrhage 12.90 11.09 29 735348 573 45950112
Thrombotic stroke 12.90 11.09 27 735350 507 45950178
Therapy cessation 12.86 11.09 320 735057 26309 45924376
Cardiac valve disease 12.85 11.09 107 735270 3877 45946808
Aortic aneurysm rupture 12.83 11.09 28 735349 542 45950143
Generalised tonic-clonic seizure 12.81 11.09 327 735050 26795 45923890
Capillary fragility test 12.79 11.09 7 735370 21 45950664
Ultrasound Doppler abnormal 12.77 11.09 12 735365 100 45950585
Infusion site pain 12.74 11.09 227 735150 9880 45940805
Patent ductus arteriosus 12.73 11.09 26 735351 3836 45946849
Catheterisation cardiac 12.69 11.09 108 735269 3939 45946746
Convulsions local 12.67 11.09 4 735373 0 45950685
Capillary fragility increased 12.67 11.09 4 735373 0 45950685
Cerebral artery stenosis 12.67 11.09 22 735355 357 45950328
Deformity 12.62 11.09 65 735312 7192 45943493
Dyskinesia 12.54 11.09 353 735024 28572 45922113
Myelodysplastic syndrome 12.54 11.09 173 735204 15538 45935147
Stillbirth 12.53 11.09 56 735321 6435 45944250
Extremity necrosis 12.52 11.09 55 735322 1578 45949107
Gastrointestinal ulcer 12.50 11.09 64 735313 1959 45948726
Maternal exposure before pregnancy 12.49 11.09 33 735344 4448 45946237
Blood pressure inadequately controlled 12.48 11.09 115 735262 4291 45946394
Incorrect dose administered by device 12.47 11.09 17 735360 2943 45947742
Drug tolerance decreased 12.46 11.09 18 735359 3041 45947644
Dysarthria 12.46 11.09 716 734661 36782 45913903
Otitis media staphylococcal 12.45 11.09 5 735372 5 45950680
Hiatus hernia 12.44 11.09 377 735000 17925 45932760
Peripheral artery thrombosis 12.44 11.09 59 735318 1750 45948935
Procedural haemorrhage 12.39 11.09 72 735305 2314 45948371
Pulmonary oedema 12.36 11.09 950 734427 50155 45900530
Hemianopia 12.35 11.09 37 735340 876 45949809
Oesophageal ulcer haemorrhage 12.31 11.09 23 735354 396 45950289
Aneurysm 12.31 11.09 76 735301 2497 45948188
Urogenital haemorrhage 12.31 11.09 14 735363 149 45950536
Haemobilia 12.31 11.09 10 735367 67 45950618
Nasal disorder 12.28 11.09 68 735309 2146 45948539
Hereditary angioedema 12.28 11.09 45 735332 5471 45945214
Euphoric mood 12.27 11.09 31 735346 4241 45946444
Vascular dementia 12.26 11.09 27 735350 526 45950159
Pericarditis 12.25 11.09 285 735092 23642 45927043
Headache 12.21 11.09 7112 728265 471240 45479445
Red blood cell sedimentation rate increased 12.18 11.09 271 735106 22618 45928067
Haemorrhage subcutaneous 12.17 11.09 83 735294 2823 45947862
Oropharyngeal pain 12.15 11.09 1004 734373 73164 45877521
Retinal artery occlusion 12.14 11.09 49 735328 1353 45949332
Low birth weight baby 12.11 11.09 135 735242 5299 45945386
Acute pulmonary oedema 12.09 11.09 183 735194 7708 45942977
Idiopathic intracranial hypertension 12.07 11.09 13 735364 2496 45948189
Mobility decreased 12.04 11.09 807 734570 59787 45890898
Cardiolipin antibody positive 12.04 11.09 14 735363 153 45950532
Pneumonitis 12.03 11.09 348 735029 28072 45922613
Gastritis haemorrhagic 12.01 11.09 47 735330 1279 45949406
Umbilical haemorrhage 12.00 11.09 6 735371 14 45950671
Heart rate increased 12.00 11.09 1350 734027 73441 45877244
Eyelid haematoma 11.99 11.09 5 735372 6 45950679
Otitis media bacterial 11.99 11.09 5 735372 6 45950679
Analgesic drug level above therapeutic 11.98 11.09 15 735362 178 45950507
Cholestasis 11.97 11.09 327 735050 26566 45924119
Intestinal haematoma 11.97 11.09 9 735368 53 45950632
Troponin T increased 11.96 11.09 37 735340 892 45949793
Platelet dysfunction 11.95 11.09 11 735366 89 45950596
Platelet count increased 11.95 11.09 313 735064 14561 45936124
Injection site discolouration 11.95 11.09 62 735315 6848 45943837
Liver transplant 11.95 11.09 72 735305 2345 45948340
Liver function test increased 11.93 11.09 271 735106 22555 45928130
Tuberculin test positive 11.92 11.09 18 735359 2986 45947699
Aortic occlusion 11.92 11.09 7 735370 25 45950660
Brain compression 11.87 11.09 21 735356 346 45950339
Blood urine present 11.85 11.09 265 735112 12017 45938668
Vitamin K deficiency 11.85 11.09 24 735353 440 45950245
Leukaemia recurrent 11.84 11.09 3 735374 1306 45949379
Gastrointestinal ischaemia 11.83 11.09 16 735361 206 45950479
Hypotensive transfusion reaction 11.78 11.09 8 735369 39 45950646
Coordination abnormal 11.78 11.09 240 735137 10709 45939976
Urine albumin/creatinine ratio increased 11.77 11.09 14 735363 157 45950528
Choroidal haemorrhage 11.71 11.09 9 735368 55 45950630
Drug withdrawal syndrome neonatal 11.70 11.09 8 735369 1920 45948765
Administration site pain 11.69 11.09 30 735347 647 45950038
Hypogammaglobulinaemia 11.69 11.09 45 735332 5393 45945292
Polycythaemia vera 11.67 11.09 13 735364 135 45950550
Anaphylactic reaction 11.65 11.09 701 734676 52411 45898274
Electrocardiogram T wave inversion 11.65 11.09 95 735282 3421 45947264
Vitello-intestinal duct remnant 11.63 11.09 8 735369 40 45950645
Organising pneumonia 11.58 11.09 39 735338 4863 45945822
Gangrene 11.56 11.09 119 735258 4576 45946109
Foot deformity 11.56 11.09 172 735205 15253 45935432
Renal papillary necrosis 11.54 11.09 17 735360 238 45950447
Ileus 11.54 11.09 154 735223 13910 45936775
Vascular stent occlusion 11.53 11.09 7 735370 27 45950658
Device related thrombosis 11.53 11.09 44 735333 1183 45949502
Flatulence 11.52 11.09 561 734816 28317 45922368
Dysmorphism 11.45 11.09 8 735369 1899 45948786
Androgenetic alopecia 11.44 11.09 14 735363 162 45950523
Placental infarction 11.43 11.09 19 735358 297 45950388
Mucosal erosion 11.42 11.09 48 735329 1350 45949335
Pelvic haematoma 11.40 11.09 26 735351 519 45950166
Blood potassium decreased 11.37 11.09 720 734657 37343 45913342
Intestinal obstruction 11.36 11.09 318 735059 25757 45924928
Pregnancy with implant contraceptive 11.36 11.09 9 735368 2003 45948682
Anastomotic haemorrhage 11.35 11.09 9 735368 58 45950627
Myocardial rupture 11.35 11.09 10 735367 76 45950609
Obstructive shock 11.34 11.09 7 735370 28 45950657
Hyperlipidaemia 11.32 11.09 377 735000 18162 45932523
Talipes 11.31 11.09 4 735373 1403 45949282
Medical device discomfort 11.30 11.09 9 735368 1997 45948688
Drug ineffective for unapproved indication 11.29 11.09 186 735191 16227 45934458
Abnormal loss of weight 11.27 11.09 124 735253 4851 45945834
Mitral valve stenosis 11.24 11.09 41 735336 1078 45949607
Infusion site erythema 11.24 11.09 176 735201 7466 45943219
Osteonecrosis 11.21 11.09 314 735063 25430 45925255
Heart valve incompetence 11.19 11.09 69 735308 2266 45948419
Electrocardiogram PR prolongation 11.18 11.09 29 735348 630 45950055
Jaundice hepatocellular 11.16 11.09 7 735370 29 45950656
Feeding disorder 11.15 11.09 224 735153 9970 45940715
Diastolic dysfunction 11.13 11.09 130 735247 5162 45945523
Personality disorder 11.12 11.09 86 735291 3047 45947638
Splenic rupture 11.11 11.09 43 735334 1164 45949521

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gastrointestinal haemorrhage 1331.34 12.96 4366 635845 79080 29233187
Myocardial infarction 1223.58 12.96 5621 634590 120004 29192263
Coronary artery disease 945.13 12.96 2766 637445 46946 29265321
Acute myocardial infarction 761.64 12.96 2677 637534 50262 29262005
Drug ineffective 735.54 12.96 4273 635938 336114 28976153
Labelled drug-drug interaction medication error 628.63 12.96 940 639271 9598 29302669
Drug abuse 501.95 12.96 609 639602 81463 29230804
Off label use 455.83 12.96 3289 636922 246001 29066266
Upper gastrointestinal haemorrhage 445.72 12.96 1254 638957 20774 29291493
Gastric haemorrhage 432.52 12.96 748 639463 8719 29303548
Cardiac failure congestive 429.18 12.96 3182 637029 81225 29231042
Angina pectoris 423.65 12.96 1492 638719 28026 29284241
Cerebrovascular accident 420.49 12.96 3140 637071 80337 29231930
Melaena 399.81 12.96 1561 638650 30876 29281391
Vascular stent thrombosis 394.34 12.96 357 639854 1986 29310281
Angina unstable 374.32 12.96 819 639392 11491 29300776
Febrile neutropenia 337.34 12.96 1160 639051 105533 29206734
Death 337.09 12.96 5494 634717 351789 28960478
Thrombosis in device 283.09 12.96 363 639848 3163 29309104
Coronary artery bypass 276.29 12.96 438 639773 4724 29307543
Coronary arterial stent insertion 268.73 12.96 387 639824 3807 29308460
Chest pain 262.25 12.96 3744 636467 113883 29198384
Treatment failure 242.29 12.96 230 639981 34449 29277818
Neutropenia 238.05 12.96 1688 638523 126852 29185415
Cerebral haemorrhage 233.61 12.96 1349 638862 31538 29280729
Product use in unapproved indication 230.91 12.96 804 639407 72889 29239378
Haemorrhage 214.33 12.96 1702 638509 44377 29267890
Haematemesis 208.24 12.96 1108 639103 25095 29287172
Rectal haemorrhage 205.35 12.96 1365 638846 33574 29278693
Subdural haematoma 195.98 12.96 865 639346 18107 29294160
Lower gastrointestinal haemorrhage 195.50 12.96 485 639726 7419 29304848
Transient ischaemic attack 193.08 12.96 1055 639156 24145 29288122
Haematuria 191.29 12.96 1624 638587 43210 29269057
Syncope 187.69 12.96 2699 637512 82204 29230063
Haemorrhage intracranial 185.62 12.96 724 639487 14308 29297959
Coronary artery stenosis 185.05 12.96 518 639693 8552 29303715
Coronary artery occlusion 174.05 12.96 580 639631 10577 29301690
Drug dependence 172.62 12.96 122 640089 21173 29291094
Gastric ulcer 169.73 12.96 707 639504 14414 29297853
Pyrexia 168.11 12.96 4903 635308 289586 29022681
Aspirin-exacerbated respiratory disease 164.94 12.96 101 640110 266 29312001
Myocardial ischaemia 163.57 12.96 769 639442 16548 29295719
Malignant neoplasm progression 160.10 12.96 898 639313 71389 29240878
Epistaxis 150.58 12.96 1764 638447 51217 29261050
Bone marrow failure 146.62 12.96 257 639954 29528 29282739
Disease progression 144.28 12.96 1056 639155 78818 29233449
Acute coronary syndrome 143.34 12.96 623 639588 12950 29299317
Haematoma 142.05 12.96 938 639273 23015 29289252
Vascular stent stenosis 137.91 12.96 141 640070 933 29311334
Blood loss anaemia 137.72 12.96 417 639794 7210 29305057
Cytomegalovirus infection 136.97 12.96 183 640028 23491 29288776
Dizziness 135.08 12.96 5267 634944 189642 29122625
Foetal exposure during pregnancy 132.50 12.96 378 639833 36493 29275774
Therapeutic product effect incomplete 128.21 12.96 338 639873 33496 29278771
Hospitalisation 127.31 12.96 501 639710 43818 29268449
Mucosal inflammation 125.42 12.96 292 639919 30202 29282065
Faeces discoloured 121.41 12.96 605 639606 13341 29298926
Immune reconstitution inflammatory syndrome 120.33 12.96 24 640187 9077 29303190
Post procedural haemorrhage 119.66 12.96 407 639804 7503 29304764
Subarachnoid haemorrhage 118.69 12.96 472 639739 9414 29302853
Sepsis 118.24 12.96 2311 637900 144084 29168183
Duodenal ulcer 116.70 12.96 470 639741 9431 29302836
Infective pulmonary exacerbation of cystic fibrosis 112.51 12.96 23 640188 8549 29303718
Pancytopenia 111.61 12.96 1220 638991 83832 29228435
Graft versus host disease 111.05 12.96 39 640172 10111 29302156
Haematochezia 109.77 12.96 1167 639044 33055 29279212
Septic shock 106.81 12.96 858 639353 62749 29249518
Drug resistance 101.57 12.96 171 640040 19962 29292305
Psychotic disorder 101.10 12.96 191 640020 21324 29290943
Haemorrhagic arteriovenous malformation 100.73 12.96 75 640136 300 29311967
Seizure 99.36 12.96 1493 638718 96982 29215285
Atrial fibrillation 98.65 12.96 3017 637194 105107 29207160
Coronary artery restenosis 98.46 12.96 124 640087 1059 29311208
Leukopenia 97.79 12.96 750 639461 55409 29256858
Coronary artery thrombosis 97.55 12.96 170 640041 1994 29310273
Gastric ulcer haemorrhage 97.32 12.96 292 639919 5022 29307245
Bronchopulmonary aspergillosis 94.87 12.96 74 640137 12210 29300057
Pathogen resistance 94.29 12.96 31 640180 8379 29303888
Neurotoxicity 93.73 12.96 86 640125 13096 29299171
Haemorrhagic stroke 92.73 12.96 316 639895 5831 29306436
Product administration error 92.00 12.96 574 639637 13803 29298464
Vascular graft 91.38 12.96 133 640078 1322 29310945
Rhabdomyolysis 90.96 12.96 1885 638326 61695 29250572
Pneumocystis jirovecii pneumonia 89.55 12.96 142 640069 16978 29295289
Gastritis erosive 89.51 12.96 294 639917 5319 29306948
Rheumatoid arthritis 88.35 12.96 517 639694 40680 29271587
Febrile bone marrow aplasia 87.07 12.96 32 640179 8065 29304202
Suicidal ideation 86.37 12.96 437 639774 35677 29276590
Acute graft versus host disease 85.20 12.96 12 640199 5852 29306415
Stomatitis 84.73 12.96 459 639752 36820 29275447
Condition aggravated 84.56 12.96 2271 637940 135595 29176672
Diverticulum intestinal haemorrhagic 82.25 12.96 155 640056 1940 29310327
Small intestinal haemorrhage 80.77 12.96 153 640058 1923 29310344
Angioedema 80.28 12.96 1104 639107 33280 29278987
Aspergillus infection 79.56 12.96 61 640150 10153 29302114
Intraventricular haemorrhage 79.27 12.96 190 640021 2840 29309427
Thrombosis 78.46 12.96 1304 638907 40927 29271340
Duodenal ulcer haemorrhage 78.38 12.96 249 639962 4423 29307844
Hepatocellular injury 76.32 12.96 283 639928 25188 29287079
Injection site pain 74.07 12.96 364 639847 29946 29282321
Shock haemorrhagic 72.87 12.96 409 639802 9456 29302811
Hepatitis C 71.49 12.96 107 640104 13098 29299169
C-reactive protein abnormal 71.38 12.96 16 640195 5577 29306690
Vascular pseudoaneurysm 71.23 12.96 142 640069 1858 29310409
Neuroleptic malignant syndrome 71.12 12.96 151 640060 16144 29296123
Status epilepticus 71.00 12.96 79 640132 10993 29301274
Psoriasis 69.67 12.96 577 639634 41929 29270338
Wrong technique in product usage process 69.48 12.96 386 639825 30769 29281498
Posterior reversible encephalopathy syndrome 69.10 12.96 51 640160 8656 29303611
Retroperitoneal haematoma 68.65 12.96 161 640050 2371 29309896
Anaemia 68.41 12.96 5245 634966 202747 29109520
Ischaemic stroke 66.99 12.96 585 639626 15690 29296577
Subdural haemorrhage 66.61 12.96 172 640039 2700 29309567
Venoocclusive liver disease 66.42 12.96 29 640182 6584 29305683
Internal haemorrhage 65.55 12.96 226 639985 4196 29308071
Cerebral infarction 65.36 12.96 856 639355 25517 29286750
Bradycardia 64.76 12.96 1847 638364 63679 29248588
Asthma 63.95 12.96 481 639730 35693 29276574
Haemophagocytic lymphohistiocytosis 63.73 12.96 69 640142 9722 29302545
Intentional self-injury 63.69 12.96 120 640091 13412 29298855
Infection 63.68 12.96 1230 638981 76844 29235423
Osteonecrosis 63.57 12.96 158 640053 15977 29296290
Depression 62.89 12.96 1462 638749 88975 29223292
Product use issue 62.77 12.96 654 639557 45362 29266905
Drug withdrawal syndrome 62.73 12.96 215 639996 19594 29292673
Presyncope 61.92 12.96 569 639642 15487 29296780
Exposure during pregnancy 61.70 12.96 64 640147 9197 29303070
Drug intolerance 61.65 12.96 644 639567 44647 29267620
Fall 61.55 12.96 4597 635614 177275 29134992
Ischaemic cardiomyopathy 61.19 12.96 282 639929 6015 29306252
Ascites 60.98 12.96 483 639728 35438 29276829
Acute myeloid leukaemia 60.78 12.96 190 640021 17816 29294451
Pain 60.32 12.96 3045 637166 169596 29142671
Aggression 60.03 12.96 502 639709 36405 29275862
Product dose omission issue 59.95 12.96 1495 638716 90136 29222131
Schizophrenia 59.75 12.96 63 640148 8985 29303282
Acute graft versus host disease in skin 59.51 12.96 12 640199 4504 29307763
Hypotension 59.49 12.96 5018 635193 195547 29116720
Akathisia 59.13 12.96 26 640185 5878 29306389
Arteriosclerosis 58.72 12.96 415 639796 10418 29301849
Haemoglobin decreased 58.31 12.96 2990 637221 111108 29201159
Haematotoxicity 57.47 12.96 30 640181 6140 29306127
Myalgia 57.28 12.96 2090 638121 74577 29237690
Psoriatic arthropathy 57.03 12.96 161 640050 15600 29296667
Post transplant lymphoproliferative disorder 57.00 12.96 21 640190 5285 29306982
Toxicity to various agents 56.47 12.96 3154 637057 174029 29138238
Serotonin syndrome 56.10 12.96 195 640016 17696 29294571
Hepatocellular carcinoma 55.87 12.96 74 640137 9536 29302731
Arteriosclerosis coronary artery 55.35 12.96 419 639792 10757 29301510
Interstitial lung disease 55.19 12.96 929 639282 59268 29252999
Iron deficiency anaemia 55.08 12.96 356 639855 8668 29303599
Lymphopenia 54.15 12.96 126 640085 13037 29299230
Haemorrhagic transformation stroke 53.84 12.96 95 640116 1126 29311141
Pseudomonas infection 53.82 12.96 88 640123 10394 29301873
Gastrointestinal vascular malformation haemorrhagic 53.50 12.96 62 640149 481 29311786
Multiple organ dysfunction syndrome 53.05 12.96 996 639215 62491 29249776
Progressive multifocal leukoencephalopathy 52.81 12.96 69 640142 8944 29303323
Mania 52.70 12.96 71 640140 9083 29303184
Occult blood positive 52.15 12.96 188 640023 3572 29308695
Chronic graft versus host disease 52.13 12.96 12 640199 4107 29308160
Carotid artery stenosis 51.74 12.96 217 639994 4437 29307830
Somnolence 51.70 12.96 1624 638587 95139 29217128
Thrombocytopenia 51.60 12.96 2398 637813 134646 29177621
Alcohol abuse 51.40 12.96 25 640186 5328 29306939
Arterial haemorrhage 51.30 12.96 72 640139 690 29311577
Drug reaction with eosinophilia and systemic symptoms 51.21 12.96 377 639834 28111 29284156
Graft versus host disease in gastrointestinal tract 50.41 12.96 4 640207 3065 29309202
Intentional product use issue 50.06 12.96 517 639694 35923 29276344
Mitral valve incompetence 50.03 12.96 467 639744 12767 29299500
Graft versus host disease in skin 49.89 12.96 6 640205 3301 29308966
Epilepsy 49.40 12.96 242 639969 19927 29292340
Pericardial haemorrhage 49.39 12.96 156 640055 2762 29309505
Ventricular tachycardia 49.28 12.96 750 639461 23112 29289155
Diarrhoea 48.81 12.96 6327 633884 327776 28984491
International normalised ratio increased 48.37 12.96 1350 638861 46389 29265878
Post procedural haematoma 48.24 12.96 104 640107 1443 29310824
Traumatic intracranial haemorrhage 48.20 12.96 64 640147 579 29311688
Sedation 47.69 12.96 184 640027 16189 29296078
No adverse event 47.44 12.96 201 640010 17218 29295049
Therapeutic response decreased 47.31 12.96 315 639896 24034 29288233
Vomiting 46.55 12.96 4055 636156 215763 29096504
Thrombotic microangiopathy 46.38 12.96 70 640141 8540 29303727
Stent placement 46.28 12.96 208 640003 4388 29307879
Muscle haemorrhage 46.23 12.96 179 640032 3524 29308743
Cytomegalovirus viraemia 46.19 12.96 33 640178 5696 29306571
Spinal epidural haematoma 45.95 12.96 36 640175 158 29312109
Gastritis 45.71 12.96 645 639566 19553 29292714
Adenovirus infection 45.67 12.96 17 640194 4251 29308016
Gastritis haemorrhagic 45.64 12.96 87 640124 1099 29311168
Multiple-drug resistance 45.21 12.96 5 640206 2936 29309331
Diverticulum 45.08 12.96 272 639939 6461 29305806
Dyspnoea 45.03 12.96 7935 632276 325360 28986907
Mallory-Weiss syndrome 44.64 12.96 94 640117 1282 29310985
Heart rate decreased 44.57 12.96 663 639548 20331 29291936
Encephalopathy 44.20 12.96 457 639754 31748 29280519
Haemobilia 43.71 12.96 42 640169 255 29312012
Hyperbilirubinaemia 43.41 12.96 200 640011 16742 29295525
Therapeutic product effect decreased 43.09 12.96 405 639806 28671 29283596
Dyspnoea exertional 42.62 12.96 1025 639186 34405 29277862
Withdrawal syndrome 42.14 12.96 113 640098 11137 29301130
Extradural haematoma 41.84 12.96 84 640127 1105 29311162
Drug ineffective for unapproved indication 41.73 12.96 108 640103 10772 29301495
Hepatitis B 41.55 12.96 41 640170 6031 29306236
Sinus node dysfunction 41.03 12.96 177 640034 3666 29308601
BK virus infection 40.97 12.96 21 640190 4343 29307924
Dystonia 40.91 12.96 92 640119 9635 29302632
Peripheral arterial occlusive disease 40.67 12.96 218 639993 4950 29307317
Percutaneous coronary intervention 39.93 12.96 36 640175 199 29312068
Enthesopathy 39.83 12.96 7 640204 2899 29309368
Apparent death 39.81 12.96 13 640198 3529 29308738
Haemoptysis 39.81 12.96 907 639304 30171 29282096
Neoplasm progression 39.80 12.96 224 639987 17799 29294468
Paradoxical drug reaction 39.74 12.96 5 640206 2657 29309610
Nausea 39.46 12.96 5656 634555 291301 29020966
Abdominal wall haematoma 39.06 12.96 100 640111 1561 29310706
Peptic ulcer 38.90 12.96 139 640072 2629 29309638
Cerebellar haemorrhage 38.86 12.96 90 640121 1314 29310953
Agitation 38.73 12.96 870 639341 53203 29259064
C-reactive protein increased 38.51 12.96 675 639536 42798 29269469
Anxiety 38.48 12.96 1550 638661 88321 29223946
Synovitis 38.38 12.96 96 640115 9687 29302580
Diffuse large B-cell lymphoma 38.26 12.96 68 640143 7773 29304494
Blood bilirubin increased 38.09 12.96 552 639659 36084 29276183
Drug hypersensitivity 38.04 12.96 1144 639067 67375 29244892
Cardiac tamponade 37.99 12.96 198 640013 4446 29307821
Basilar artery thrombosis 37.93 12.96 27 640184 99 29312168
Retroperitoneal haemorrhage 37.86 12.96 136 640075 2579 29309688
Duodenitis 37.84 12.96 179 640032 3861 29308406
Ventricular fibrillation 37.78 12.96 492 639719 14646 29297621
Cardiac ventricular thrombosis 37.75 12.96 64 640147 733 29311534
Peritonitis bacterial 37.74 12.96 121 640090 11257 29301010
Eye haemorrhage 37.50 12.96 168 640043 3539 29308728
Peritonitis 36.93 12.96 286 639925 21089 29291178
Poisoning deliberate 36.90 12.96 43 640168 5861 29306406
Ulcer haemorrhage 36.76 12.96 126 640085 2332 29309935
Viral mutation identified 36.72 12.96 6 640205 2620 29309647
Thalamus haemorrhage 36.52 12.96 70 640141 888 29311379
Swollen tongue 36.45 12.96 437 639774 12755 29299512
Contusion 36.43 12.96 901 639310 30379 29281888
Large intestinal haemorrhage 36.42 12.96 94 640117 1475 29310792
Neutrophil count decreased 36.08 12.96 664 639547 41790 29270477
Incorrect route of product administration 35.70 12.96 123 640088 11192 29301075
Cystitis haemorrhagic 35.52 12.96 30 640181 4757 29307510
Gastrointestinal ulcer 35.41 12.96 99 640112 1633 29310634
Hiatus hernia 35.21 12.96 266 639945 6824 29305443
Lipodystrophy acquired 35.15 12.96 16 640195 3544 29308723
Product monitoring error 35.08 12.96 99 640112 1642 29310625
Abnormal behaviour 35.00 12.96 364 639847 25259 29287008
Cytomegalovirus chorioretinitis 35.00 12.96 13 640198 3255 29309012
Loss of personal independence in daily activities 34.97 12.96 293 639918 21242 29291025
Transplant rejection 34.84 12.96 92 640119 9114 29303153
Hepatic function abnormal 34.73 12.96 659 639552 41286 29270981
Injection site reaction 34.60 12.96 116 640095 10644 29301623
Pallor 34.44 12.96 637 639574 20412 29291855
Unintentional medical device removal 34.39 12.96 3 640208 2128 29310139
Exposure to toxic agent 34.36 12.96 75 640136 1050 29311217
Gingival bleeding 33.94 12.96 244 639967 6160 29306107
Respiratory tract haemorrhage 33.67 12.96 63 640148 784 29311483
Tongue haematoma 33.58 12.96 27 640184 124 29312143
Hemiplegia 33.13 12.96 250 639961 6411 29305856
Generalised tonic-clonic seizure 33.12 12.96 263 639948 19288 29292979
Drug use disorder 33.01 12.96 14 640197 3234 29309033
Irritability 32.91 12.96 324 639887 22726 29289541
Gastrointestinal polyp haemorrhage 32.90 12.96 35 640176 244 29312023
Epstein-Barr virus infection 32.87 12.96 58 640153 6648 29305619
Embolic stroke 32.85 12.96 159 640052 3463 29308804
Device related infection 32.61 12.96 221 639990 16794 29295473
Acute graft versus host disease in intestine 32.52 12.96 6 640205 2399 29309868
Cystic fibrosis 32.24 12.96 5 640206 2269 29309998
Hypoglycaemia 32.23 12.96 1365 638846 49616 29262651
Gastrointestinal arteriovenous malformation 32.23 12.96 40 640171 336 29311931
Carotid artery occlusion 32.23 12.96 106 640105 1919 29310348
Peptic ulcer haemorrhage 32.16 12.96 45 640166 430 29311837
Intermittent claudication 32.09 12.96 113 640098 2121 29310146
Cytokine release syndrome 32 12.96 107 640104 9826 29302441
Gastrointestinal ulcer haemorrhage 31.86 12.96 53 640158 597 29311670
Haemorrhage urinary tract 31.79 12.96 93 640118 1576 29310691
Osteonecrosis of jaw 31.75 12.96 250 639961 18368 29293899
Mobility decreased 31.69 12.96 379 639832 25620 29286647
Angiocardiogram 31.68 12.96 29 640182 164 29312103
Chest discomfort 31.58 12.96 1230 638981 44250 29268017
Pneumonia 31.37 12.96 6490 633721 327816 28984451
Suicide attempt 31.17 12.96 574 639637 36123 29276144
Fat embolism 30.88 12.96 30 640181 185 29312082
Colitis 30.78 12.96 468 639743 30352 29281915
Pulmonary tuberculosis 30.76 12.96 35 640176 4822 29307445
Product quality issue 30.68 12.96 255 639956 18519 29293748
Hyperammonaemia 30.59 12.96 44 640167 5476 29306791
Rash maculo-papular 30.42 12.96 372 639839 25046 29287221
Drug withdrawal syndrome neonatal 30.22 12.96 15 640196 3160 29309107
Therapy partial responder 30.10 12.96 21 640190 3670 29308597
Venoocclusive disease 30.01 12.96 9 640202 2581 29309686
Cerebral haematoma 29.99 12.96 182 640029 4332 29307935
Haematocrit decreased 29.94 12.96 864 639347 29835 29282432
Neutropenic sepsis 29.64 12.96 134 640077 11275 29300992
Tuberculosis 29.60 12.96 82 640129 7995 29304272
Diastolic dysfunction 29.53 12.96 174 640037 4097 29308170
Blood pressure increased 29.53 12.96 1848 638363 70080 29242187
Obsessive-compulsive disorder 29.46 12.96 27 640184 4114 29308153
Pulmonary alveolar haemorrhage 29.43 12.96 241 639970 6340 29305927
Haemorrhagic erosive gastritis 29.42 12.96 24 640187 113 29312154
Candida infection 29.21 12.96 200 640011 15162 29297105
Atrial flutter 29.15 12.96 448 639763 13833 29298434
Asthenia 29.09 12.96 5262 634949 216028 29096239
Neutrophil count increased 28.89 12.96 200 640011 15123 29297144
Respiratory failure 28.87 12.96 1809 638402 98833 29213434
Arterial occlusive disease 28.85 12.96 166 640045 3874 29308393
Joint swelling 28.80 12.96 773 639438 46173 29266094
Coronary artery aneurysm 28.68 12.96 19 640192 60 29312207
Leukoencephalopathy 28.58 12.96 26 640185 3976 29308291
Hemiparesis 28.57 12.96 460 639751 14342 29297925
Multiple injuries 28.39 12.96 101 640110 1906 29310361
Peripheral vascular disorder 28.32 12.96 200 640011 5019 29307248
Sinus bradycardia 28.31 12.96 378 639833 11317 29300950
Klebsiella infection 28.27 12.96 66 640145 6821 29305446
Mucormycosis 28.21 12.96 43 640168 5225 29307042
Aortic stenosis 28.04 12.96 165 640046 3883 29308384
Coronary artery perforation 27.96 12.96 17 640194 44 29312223
Pharyngeal haemorrhage 27.85 12.96 52 640159 646 29311621
Staphylococcal infection 27.83 12.96 466 639745 29758 29282509
Electrocardiogram ST segment depression 27.73 12.96 112 640099 2250 29310017
Urinary bladder haemorrhage 27.70 12.96 88 640123 1563 29310704
Fungal infection 27.40 12.96 174 640037 13426 29298841
Heparin-induced thrombocytopenia 27.32 12.96 203 640008 5180 29307087
Acute hepatic failure 27.29 12.96 379 639832 11448 29300819
Aortic aneurysm 27.16 12.96 232 639979 6181 29306086
Hypogammaglobulinaemia 27.05 12.96 44 640167 5208 29307059
Haemorrhagic cerebral infarction 27.03 12.96 55 640156 731 29311536
Ventricular extrasystoles 27.01 12.96 369 639842 11105 29301162
Pneumonia cytomegaloviral 26.93 12.96 13 640198 2783 29309484
Mitochondrial toxicity 26.92 12.96 10 640201 2504 29309763
Colitis ulcerative 26.91 12.96 189 640022 14245 29298022
Product prescribing error 26.89 12.96 505 639706 16228 29296039
Mediastinal haematoma 26.83 12.96 21 640190 92 29312175
Myelodysplastic syndrome 26.78 12.96 264 639947 18514 29293753
Aplasia 26.78 12.96 28 640183 4009 29308258
Pulmonary haematoma 26.73 12.96 17 640194 49 29312218
Agranulocytosis 26.69 12.96 320 639891 21622 29290645
Blood pressure fluctuation 26.68 12.96 524 639687 16979 29295288
Ecchymosis 26.61 12.96 234 639977 6288 29305979
Product storage error 26.43 12.96 61 640150 6330 29305937
Systemic candida 26.40 12.96 13 640198 2751 29309516
Viral load increased 26.40 12.96 14 640197 2840 29309427
High density lipoprotein decreased 26.35 12.96 137 640074 3073 29309194
Myelosuppression 26.34 12.96 75 640136 7247 29305020
Lacunar infarction 26.14 12.96 135 640076 3020 29309247
Large intestine polyp 25.99 12.96 238 639973 6471 29305796
Procedural haemorrhage 25.98 12.96 109 640102 2229 29310038
Tumour lysis syndrome 25.89 12.96 165 640046 12720 29299547
Tricuspid valve incompetence 25.77 12.96 290 639921 8333 29303934
Hypertriglyceridaemia 25.57 12.96 88 640123 8010 29304257
Eosinophilia 25.51 12.96 327 639884 21833 29290434
Respiratory distress 25.49 12.96 524 639687 32448 29279819
Hepatitis B reactivation 25.33 12.96 15 640196 2862 29309405
Erosive duodenitis 25.27 12.96 77 640134 1336 29310931
Left ventricular failure 25.21 12.96 188 640023 4803 29307464
Arterial restenosis 25.10 12.96 18 640193 67 29312200
Colonic haematoma 25.05 12.96 14 640197 29 29312238
Lymphoma 25.03 12.96 121 640090 10000 29302267
Headache 24.99 12.96 3465 636746 178841 29133426
Disseminated intravascular coagulation 24.85 12.96 329 639882 21842 29290425
Blood creatine phosphokinase MB increased 24.79 12.96 95 640116 1861 29310406
Venous pressure jugular increased 24.74 12.96 50 640161 661 29311606
Troponin increased 24.74 12.96 294 639917 8563 29303704
Device issue 24.63 12.96 85 640126 7731 29304536
Bacterial infection 24.56 12.96 163 640048 12447 29299820
Arthralgia 24.55 12.96 2534 637677 133257 29179010
Full blood count decreased 24.46 12.96 472 639739 15245 29297022
Second primary malignancy 24.45 12.96 63 640148 6293 29305974
Atrioventricular block complete 24.39 12.96 283 639928 8194 29304073
Vascular graft occlusion 24.31 12.96 45 640166 555 29311712
Ventricular hypokinesia 24.20 12.96 164 640047 4059 29308208
Heart rate irregular 24.04 12.96 382 639829 11877 29300390
Cardiac disorder 23.85 12.96 1062 639149 38831 29273436
Body height decreased 23.83 12.96 149 640062 3585 29308682
Carotid artery disease 23.80 12.96 59 640152 902 29311365
Poisoning 23.78 12.96 144 640067 11238 29301029
Cardiac failure chronic 23.74 12.96 210 640001 5653 29306614
Hyperthermia 23.69 12.96 123 640088 9976 29302291
Mouth haemorrhage 23.68 12.96 186 640025 4831 29307436
Atrioventricular block 23.65 12.96 249 639962 7033 29305234
Basal ganglia haemorrhage 23.53 12.96 55 640156 808 29311459
Head injury 23.46 12.96 502 639709 16518 29295749
Kidney transplant rejection 23.44 12.96 82 640129 7427 29304840
Palmar-plantar erythrodysaesthesia syndrome 23.39 12.96 204 640007 14666 29297601
Paranoia 23.38 12.96 125 640086 10063 29302204
Bleeding time prolonged 23.22 12.96 46 640165 599 29311668
Brain stem haemorrhage 23.16 12.96 54 640157 792 29311475
Cerebral artery occlusion 23.05 12.96 51 640160 721 29311546
Vascular stent occlusion 23.04 12.96 21 640190 118 29312149
Myocardial rupture 23.02 12.96 24 640187 163 29312104
Injection site erythema 23.02 12.96 187 640024 13647 29298620
Euphoric mood 22.99 12.96 35 640176 4255 29308012
Haemothorax 22.89 12.96 142 640069 3407 29308860
Coagulopathy 22.88 12.96 537 639674 17950 29294317
Nocardiosis 22.88 12.96 24 640187 3431 29308836
Cardiogenic shock 22.82 12.96 496 639715 16365 29295902
Device use error 22.74 12.96 7 640204 1974 29310293
Splenic haematoma 22.72 12.96 22 640189 135 29312132
Non-cardiac chest pain 22.70 12.96 158 640053 3946 29308321
Gout 22.69 12.96 507 639704 16808 29295459
Hepatic encephalopathy 22.63 12.96 194 640017 13998 29298269
Puncture site haemorrhage 22.56 12.96 32 640179 310 29311957
Intercepted product preparation error 22.46 12.96 3 640208 1523 29310744
Tongue oedema 22.38 12.96 118 640093 2662 29309605
Toxic anterior segment syndrome 22.36 12.96 3 640208 1518 29310749
Enterococcal infection 22.33 12.96 95 640116 8129 29304138
Erythema 22.23 12.96 1392 638819 76059 29236208
Scrotal haematoma 22.14 12.96 17 640194 72 29312195
Acute lymphocytic leukaemia recurrent 21.98 12.96 15 640196 2652 29309615
Anion gap 21.97 12.96 45 640166 601 29311666
Completed suicide 21.93 12.96 1829 638382 97663 29214604
Aortic aneurysm rupture 21.93 12.96 61 640150 1003 29311264
Coronary angioplasty 21.81 12.96 34 640177 361 29311906
Pharyngeal haematoma 21.73 12.96 12 640199 24 29312243
Electrocardiogram ST segment elevation 21.69 12.96 166 640045 4276 29307991
Miosis 21.62 12.96 89 640122 7687 29304580
Foetal exposure timing unspecified 21.59 12.96 26 640185 211 29312056
Haemorrhoidal haemorrhage 21.56 12.96 128 640083 3022 29309245
Tenosynovitis 21.54 12.96 26 640185 3489 29308778
Hallucination, auditory 21.43 12.96 122 640089 9667 29302600
Salivary hypersecretion 21.41 12.96 86 640125 7480 29304787
Acute respiratory distress syndrome 21.25 12.96 363 639848 23109 29289158
Social avoidant behaviour 21.17 12.96 18 640193 2845 29309422
Oesophageal ulcer 21.06 12.96 131 640080 3146 29309121
Hypomania 20.97 12.96 11 640200 2245 29310022
Haemorrhagic infarction 20.93 12.96 33 640178 354 29311913
Cardio-respiratory arrest 20.87 12.96 1006 639205 56300 29255967
Cytopenia 20.83 12.96 98 640113 8158 29304109
Cardiac aneurysm 20.80 12.96 44 640167 602 29311665
Ventricular dysfunction 20.77 12.96 142 640069 3525 29308742
Cerebral microhaemorrhage 20.75 12.96 14 640197 46 29312221
Metastases to liver 20.71 12.96 160 640051 11805 29300462
Ageusia 20.69 12.96 287 639924 8666 29303601
Helicobacter test positive 20.68 12.96 38 640173 466 29311801
Oral candidiasis 20.62 12.96 145 640066 10926 29301341
Uveitis 20.52 12.96 55 640156 5422 29306845
Orthostatic hypotension 20.47 12.96 664 639547 23315 29288952
Subcutaneous haematoma 20.45 12.96 56 640155 912 29311355
Chromaturia 20.44 12.96 413 639798 13452 29298815
Labelled drug-disease interaction medication error 20.43 12.96 18 640193 96 29312171
Hypofibrinogenaemia 20.41 12.96 5 640206 1640 29310627
Hyperammonaemic encephalopathy 20.32 12.96 7 640204 1837 29310430
Essential hypertension 20.30 12.96 106 640105 2382 29309885
Ventricular hypertrophy 20.28 12.96 176 640035 4711 29307556
Brain contusion 20.25 12.96 49 640162 737 29311530
Sinus arrest 20.24 12.96 75 640136 1445 29310822
Bundle branch block right 20.22 12.96 235 639976 6807 29305460
Oesophageal intramural haematoma 20.21 12.96 10 640201 14 29312253
Blood pressure diastolic decreased 20.21 12.96 213 639998 6018 29306249
Colitis microscopic 20.19 12.96 81 640130 1622 29310645
Coma 20.12 12.96 685 639526 39764 29272503
Actinic elastosis 20.08 12.96 13 640198 39 29312228
Intestinal diaphragm disease 19.75 12.96 26 640185 233 29312034
Incision site haemorrhage 19.73 12.96 38 640173 484 29311783
Terminal state 19.70 12.96 29 640182 3575 29308692
Premature baby 19.70 12.96 245 639966 16446 29295821
Growth retardation 19.59 12.96 5 640206 1595 29310672
Accidental exposure to product 19.57 12.96 131 640080 9984 29302283
Spontaneous haematoma 19.32 12.96 38 640173 492 29311775
Epigastric discomfort 19.25 12.96 89 640122 1901 29310366
Blindness transient 19.23 12.96 88 640123 1871 29310396
Atrioventricular block first degree 19.19 12.96 196 640015 5492 29306775
Intestinal obstruction 19.09 12.96 292 639919 18920 29293347
Developmental delay 19.08 12.96 11 640200 2130 29310137
Cerebral artery stenosis 19.05 12.96 29 640182 301 29311966
Prothrombin time prolonged 19.05 12.96 292 639919 9011 29303256
Aortic intramural haematoma 19.03 12.96 11 640200 25 29312242
Human herpesvirus 6 infection 19.02 12.96 9 640202 1949 29310318
Glomerular filtration rate decreased 18.99 12.96 345 639866 11017 29301250
Pneumonia aspiration 18.98 12.96 639 639572 37141 29275126
Precancerous skin lesion 18.97 12.96 40 640171 546 29311721
Gastrooesophageal reflux disease 18.91 12.96 857 639354 31398 29280869
Mycobacterium avium complex infection 18.90 12.96 18 640193 2693 29309574
Hyperlipidaemia 18.79 12.96 409 639802 13498 29298769
Sudden cardiac death 18.76 12.96 141 640070 3611 29308656
Bone erosion 18.76 12.96 13 640198 2280 29309987
Intra-abdominal haematoma 18.75 12.96 67 640144 1267 29311000
Cataract 18.74 12.96 605 639606 21230 29291037
Electrocardiogram QT prolonged 18.73 12.96 603 639608 35232 29277035
Increased tendency to bruise 18.72 12.96 136 640075 3445 29308822
Arteriovenous malformation 18.69 12.96 41 640170 576 29311691
Coronary artery dissection 18.68 12.96 21 640190 157 29312110
Platelet dysfunction 18.68 12.96 22 640189 174 29312093
Peripheral ischaemia 18.57 12.96 185 640026 5149 29307118
Disturbance in attention 18.52 12.96 347 639864 21782 29290485
Arterial stenosis 18.50 12.96 63 640148 1162 29311105
Small intestine ulcer 18.50 12.96 34 640177 417 29311850
Device embolisation 18.43 12.96 10 640201 19 29312248
Peripheral artery stenosis 18.42 12.96 50 640161 810 29311457
Brain stem stroke 18.33 12.96 19 640192 128 29312139
Strongyloidiasis 18.28 12.96 14 640197 2332 29309935
Hepatic failure 18.24 12.96 571 639640 33472 29278795
Insomnia 18.20 12.96 1732 638479 91604 29220663
Blood HIV RNULL increased 18.17 12.96 4 640207 1412 29310855
Cerebrovascular disorder 18.06 12.96 88 640123 1922 29310345
Reye's syndrome 18.06 12.96 8 640203 7 29312260
Haemorrhage subcutaneous 18.04 12.96 95 640116 2142 29310125
Hypoalbuminaemia 17.97 12.96 151 640060 10941 29301326
Neoplasm malignant 17.96 12.96 270 639941 17544 29294723
Catheter site haematoma 17.74 12.96 20 640191 150 29312117
JC virus infection 17.74 12.96 8 640203 1782 29310485
Coronary ostial stenosis 17.73 12.96 15 640196 75 29312192
Blood creatine phosphokinase increased 17.70 12.96 1125 639086 42723 29269544
Cholestasis 17.69 12.96 402 639809 24548 29287719
Naevus flammeus 17.60 12.96 19 640192 135 29312132
Extrapyramidal disorder 17.58 12.96 145 640066 10548 29301719
Colon adenoma 17.53 12.96 63 640148 1195 29311072
Aortic valve sclerosis 17.51 12.96 51 640160 862 29311405
Fanconi syndrome 17.49 12.96 8 640203 1767 29310500
Cardiac murmur 17.42 12.96 223 639988 6611 29305656
Conjunctival haemorrhage 17.40 12.96 108 640103 2592 29309675
Ankylosing spondylitis 17.39 12.96 45 640166 4489 29307778
Anastomotic ulcer haemorrhage 17.30 12.96 9 640202 15 29312252
Myocarditis 17.27 12.96 134 640077 9877 29302390
Angioplasty 17.25 12.96 55 640156 979 29311288
Thalamic infarction 17.22 12.96 41 640170 610 29311657
Finger amputation 17.21 12.96 21 640190 173 29312094
Meningitis cryptococcal 17.20 12.96 11 640200 2013 29310254
Dermatitis acneiform 17.17 12.96 63 640148 5626 29306641
Alopecia 17.15 12.96 299 639912 18976 29293291
Surgery 17.06 12.96 161 640050 11390 29300877
Bacteraemia 17.04 12.96 232 639979 15328 29296939
Subcapsular renal haematoma 17.04 12.96 30 640181 355 29311912
Basal ganglia infarction 16.97 12.96 18 640193 125 29312142
Skin toxicity 16.94 12.96 27 640184 3222 29309045
Erosive oesophagitis 16.92 12.96 68 640143 1363 29310904
Abscess 16.87 12.96 136 640075 9942 29302325
Drug eruption 16.87 12.96 268 639943 17258 29295009
Ill-defined disorder 16.86 12.96 143 640068 10341 29301926
Granulocytopenia 16.85 12.96 72 640139 6154 29306113
Behaviour disorder 16.84 12.96 16 640195 2396 29309871
Lymphocyte count decreased 16.83 12.96 296 639915 18759 29293508
Antipsychotic drug level increased 16.80 12.96 26 640185 3140 29309127
Carotid bruit 16.74 12.96 24 640187 235 29312032
Cardiovascular disorder 16.73 12.96 328 639883 10624 29301643
Malaise 16.70 12.96 3230 636981 163732 29148535
Periorbital oedema 16.64 12.96 125 640086 3201 29309066
Vertebral artery stenosis 16.62 12.96 19 640192 145 29312122
Multiple allergies 16.59 12.96 90 640121 2053 29310214
Haematoma muscle 16.44 12.96 38 640173 554 29311713
Anger 16.42 12.96 155 640056 10965 29301302
Splenic injury 16.42 12.96 10 640201 26 29312241
Aortic bypass 16.40 12.96 7 640204 5 29312262
Persecutory delusion 16.39 12.96 13 640198 2127 29310140
Blood pressure decreased 16.39 12.96 1193 639018 45882 29266385
Wound haemorrhage 16.36 12.96 79 640132 1719 29310548
Platelet function test abnormal 16.31 12.96 16 640195 100 29312167
Kounis syndrome 16.31 12.96 75 640136 1598 29310669
Implant site haematoma 16.26 12.96 14 640197 72 29312195
Hyperprolactinaemia 16.21 12.96 3 640208 1197 29311070
Hepatojugular reflux 16.15 12.96 28 640183 327 29311940
Intracranial aneurysm 16.11 12.96 58 640153 1101 29311166
Ruptured cerebral aneurysm 16.07 12.96 18 640193 134 29312133
Haemorrhoids 16.06 12.96 356 639855 11785 29300482
Basilar artery stenosis 15.99 12.96 9 640202 19 29312248
Vessel puncture site haemorrhage 15.98 12.96 14 640197 74 29312193
Blood glucose increased 15.95 12.96 1525 638686 60005 29252262
Maternal drugs affecting foetus 15.94 12.96 43 640168 4230 29308037
Vessel puncture site haematoma 15.94 12.96 12 640199 49 29312218
Nocturia 15.92 12.96 258 639953 8054 29304213
Microcytic anaemia 15.88 12.96 90 640121 2088 29310179
Diverticulum oesophageal 15.86 12.96 7 640204 6 29312261
Respiratory arrest 15.85 12.96 490 639721 28768 29283499
Muscular weakness 15.85 12.96 1573 638638 62072 29250195
Fanconi syndrome acquired 15.82 12.96 13 640198 2090 29310177
Intracardiac thrombus 15.82 12.96 98 640113 2350 29309917
Oesophagitis haemorrhagic 15.81 12.96 22 640189 209 29312058
Peritoneal dialysis complication 15.80 12.96 41 640170 4086 29308181
Tongue disorder 15.75 12.96 44 640167 4278 29307989
Crying 15.72 12.96 64 640147 5545 29306722
Device malfunction 15.72 12.96 105 640106 8006 29304261
HIV infection 15.70 12.96 8 640203 1660 29310607
Tachycardia 15.58 12.96 1360 638851 72379 29239888
Disturbance in social behaviour 15.50 12.96 6 640205 1465 29310802
Device leakage 15.48 12.96 35 640176 3659 29308608
Extraocular muscle disorder 15.45 12.96 20 640191 176 29312091
Cardiac valve disease 15.42 12.96 112 640099 2837 29309430
Haemorrhagic diathesis 15.42 12.96 108 640103 2703 29309564
Multiple sclerosis relapse 15.37 12.96 153 640058 10709 29301558
Diverticulitis intestinal haemorrhagic 15.36 12.96 28 640183 341 29311926
Cerebral small vessel ischaemic disease 15.36 12.96 23 640188 235 29312032
Polycythaemia vera 15.35 12.96 21 640190 196 29312071
White blood cell count increased 15.34 12.96 692 639519 38981 29273286
Thrombotic stroke 15.25 12.96 24 640187 257 29312010
Coagulation time abnormal 15.19 12.96 19 640192 161 29312106
Drug level decreased 15.19 12.96 68 640143 5737 29306530
Maternal exposure during pregnancy 15.17 12.96 38 640173 3833 29308434
Cardiac failure 15.14 12.96 2020 638191 81398 29230869
Cardiac valve replacement complication 15.14 12.96 11 640200 42 29312225
Herpes simplex 15.14 12.96 47 640164 4417 29307850
Fear 15.10 12.96 153 640058 10672 29301595
Bundle branch block left 15.09 12.96 174 640037 5030 29307237
Helicobacter gastritis 15.07 12.96 46 640165 799 29311468
Arterial spasm 14.99 12.96 16 640195 112 29312155
Prostatic haemorrhage 14.94 12.96 19 640192 164 29312103
Polyneuropathy 14.93 12.96 171 640040 11652 29300615
Metastases to lung 14.90 12.96 103 640108 7792 29304475
Ischaemia 14.87 12.96 155 640056 4366 29307901
Disease recurrence 14.84 12.96 213 639998 13948 29298319
Pneumonitis 14.82 12.96 460 639751 26994 29285273
Sinonasal obstruction 14.81 12.96 8 640203 15 29312252
Tooth socket haemorrhage 14.81 12.96 8 640203 15 29312252
Shone complex 14.80 12.96 13 640198 69 29312198
Fistula 14.63 12.96 58 640153 5064 29307203
Tardive dyskinesia 14.62 12.96 57 640154 5000 29307267
Vitreous haemorrhage 14.61 12.96 86 640125 2024 29310243
Brain stem infarction 14.60 12.96 61 640150 1245 29311022
Diverticulum intestinal 14.58 12.96 120 640091 3162 29309105
Throat lesion 14.57 12.96 14 640197 85 29312182
Hyphaema 14.57 12.96 29 640182 379 29311888
Mental disorder 14.55 12.96 201 640010 13248 29299019
Drug screen positive 14.52 12.96 47 640164 4360 29307907
Lung disorder 14.49 12.96 538 639673 30931 29281336
Periorbital haemorrhage 14.48 12.96 15 640196 101 29312166
Traumatic haematoma 14.48 12.96 40 640171 655 29311612
Hypovolaemic shock 14.47 12.96 207 640004 6293 29305974
Electrocardiogram PR prolongation 14.45 12.96 42 640169 709 29311558
Blue toe syndrome 14.44 12.96 18 640193 152 29312115
Hyperreflexia 14.42 12.96 24 640187 2815 29309452
Hypokalaemia 14.41 12.96 902 639309 49290 29262977
Genotype drug resistance test positive 14.40 12.96 8 640203 1581 29310686
Infarction 14.40 12.96 101 640110 2529 29309738
Benign prostatic hyperplasia 14.36 12.96 308 639903 10139 29302128
Orthostatic intolerance 14.35 12.96 41 640170 685 29311582
Ventricular septal defect 14.34 12.96 34 640177 3495 29308772
Polyomavirus-associated nephropathy 14.33 12.96 29 640182 3156 29309111
Low density lipoprotein increased 14.33 12.96 140 640071 3876 29308391
Traumatic haemothorax 14.27 12.96 21 640190 211 29312056
Blood cholesterol increased 14.25 12.96 469 639742 16501 29295766
Herpes zoster 14.22 12.96 510 639701 29433 29282834
Left ventricular dysfunction 14.21 12.96 263 639948 8428 29303839
Encephalitis 14.20 12.96 80 640131 6356 29305911
Hypertensive emergency 14.17 12.96 45 640166 799 29311468
Scrotal mass 14.14 12.96 9 640202 26 29312241
Intra-abdominal haemorrhage 14.12 12.96 85 640126 2017 29310250
Dermatitis exfoliative generalised 14.11 12.96 24 640187 2791 29309476
Hypertensive crisis 14.05 12.96 254 639957 8103 29304164
Gastric mucosal lesion 14.03 12.96 34 640177 512 29311755
Duodenitis haemorrhagic 13.99 12.96 14 640197 90 29312177
Cerebral toxoplasmosis 13.94 12.96 7 640204 1465 29310802
Toxic encephalopathy 13.94 12.96 51 640160 4558 29307709
Chronic gastritis 13.93 12.96 55 640156 1093 29311174
Carcinogenicity 13.90 12.96 12 640199 62 29312205
Extravasation blood 13.87 12.96 14 640197 91 29312176
Silent myocardial infarction 13.86 12.96 28 640183 370 29311897
Dermatomyositis 13.86 12.96 52 640159 1008 29311259
Peripheral artery aneurysm 13.86 12.96 27 640184 347 29311920
Arteriovenous fistula 13.83 12.96 37 640174 594 29311673
Rhythm idioventricular 13.77 12.96 23 640188 260 29312007
Endophthalmitis 13.77 12.96 34 640177 3446 29308821
Coronary artery insufficiency 13.75 12.96 15 640196 108 29312159
Muscle spasms 13.70 12.96 1585 638626 63253 29249014
Stent-graft endoleak 13.68 12.96 9 640202 28 29312239
Cytomegalovirus infection reactivation 13.67 12.96 10 640201 1705 29310562
Mood swings 13.66 12.96 101 640110 7525 29304742
Coronary artery surgery 13.65 12.96 15 640196 109 29312158
Coronary artery reocclusion 13.65 12.96 15 640196 109 29312158
Disinhibition 13.64 12.96 13 640198 1944 29310323
Toxic skin eruption 13.64 12.96 160 640051 10855 29301412
Hypocoagulable state 13.59 12.96 47 640164 874 29311393
Aortic valve incompetence 13.56 12.96 163 640048 4760 29307507
Gallbladder disorder 13.53 12.96 188 640023 5679 29306588
Gastrointestinal angiodysplasia 13.53 12.96 32 640179 474 29311793
Cardiac stress test abnormal 13.51 12.96 26 640185 331 29311936
Acute graft versus host disease in liver 13.41 12.96 5 640206 1249 29311018
Splenic haemorrhage 13.41 12.96 27 640184 356 29311911
Arterial stent insertion 13.40 12.96 13 640198 80 29312187
Incision site haematoma 13.40 12.96 13 640198 80 29312187
Complications of transplanted kidney 13.33 12.96 44 640167 4057 29308210
Dyskinesia 13.26 12.96 360 639851 21474 29290793
Panic attack 13.25 12.96 120 640091 8561 29303706
Therapy non-responder 13.23 12.96 505 639706 28948 29283319
Rash 13.19 12.96 3778 636433 188111 29124156
Electrocardiogram T wave inversion 13.16 12.96 85 640126 2069 29310198
Delirium 13.13 12.96 722 639489 39909 29272358
Drug abuser 13.11 12.96 49 640162 4352 29307915
Bradypnoea 13.11 12.96 13 640198 1908 29310359
Extrasystoles 13.08 12.96 131 640080 3651 29308616
Lactose intolerance 13.06 12.96 44 640167 807 29311460
Blood pressure systolic increased 13.05 12.96 419 639792 14691 29297576
Talipes 13.05 12.96 10 640201 1665 29310602
Hepatic cirrhosis 13.04 12.96 252 639959 15747 29296520
Gastrointestinal perforation 13.04 12.96 37 640174 3579 29308688
Full blood count increased 13.03 12.96 43 640168 780 29311487
Monoplegia 13.02 12.96 62 640149 1341 29310926
Hypotonia neonatal 13.02 12.96 3 640208 1026 29311241
Blood urine present 13.01 12.96 290 639921 9610 29302657

Pharmacologic Action:

SourceCodeDescription
ATC A01AD05 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Other agents for local oral treatment
ATC B01AC06 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Platelet aggregation inhibitors excl. heparin
ATC N02BA01 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
ATC B01AC56 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Platelet aggregation inhibitors excl. heparin
ATC C07FX02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
ATC C07FX03 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
ATC C07FX04 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
ATC C10BX01 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX02 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX04 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX05 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX06 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX08 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX12 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC M01BA03 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY/ANTIRHEUMATIC AGENTS IN COMBINATION
Antiinflammatory/antirheumatic agents in combination with corticosteroids
ATC N02AJ02 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ07 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ18 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02BA51 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
ATC N02BA71 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
FDA CS M0001335 Anti-Inflammatory Agents, Non-Steroidal
FDA MoA N0000000160 Cyclooxygenase Inhibitors
FDA PE N0000008832 Decreased Platelet Aggregation
FDA PE N0000008836 Decreased Prostaglandin Production
FDA EPC N0000175578 Platelet Aggregation Inhibitor
FDA EPC N0000175722 Nonsteroidal Anti-inflammatory Drug
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D058633 Antipyretics
MeSH PA D018501 Antirheumatic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D016861 Cyclooxygenase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005343 Fibrinolytic Agents
MeSH PA D006401 Hematologic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D010975 Platelet Aggregation Inhibitors
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drugs
CHEBI has role CHEBI:35493 anti-pyretic
CHEBI has role CHEBI:49023 prostaglandin inhibitor
CHEBI has role CHEBI:50249 anticoagulante
CHEBI has role CHEBI:50427 platelet aggregation inhibitors
CHEBI has role CHEBI:50629 cyclooxygenase-2 inhibitor
CHEBI has role CHEBI:50630 cyclooxygenase-1 inhibitor
CHEBI has role CHEBI:50905 teratogen
CHEBI has role CHEBI:73182 plant activators
CHEBI has role CHEBI:77425 (5z,13e)-(15s)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:nadp(+) 11-oxidoreductase inhibitors
CHEBI has role CHEBI:88188 allergenic drug

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Sinus headache indication 4969004
Pain indication 22253000
Myocardial infarction indication 22298006 DOID:5844
Toothache indication 27355003
Migraine indication 37796009 DOID:6364
Joint pain indication 57676002
Rheumatoid arthritis indication 69896004 DOID:7148
Common cold indication 82272006 DOID:10459
Backache indication 161891005
Headache disorder indication 230461009
Influenza-like symptoms indication 315642008
Osteoarthritis indication 396275006
Arthritic Pain indication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.57 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 5.12 WOMBAT-PK CHEMBL
Prostaglandin G/H synthase 1 Enzyme INHIBITOR IC50 5.77 WOMBAT-PK CHEMBL
Gamma-glutamyltranspeptidase 1 Enzyme IC50 4.44 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 5.62 CHEMBL
Acidic phospholipase A2 3 Enzyme Kd 5.20 WOMBAT-PK
Prostaglandin G/H synthase 1 Enzyme IC50 6.52 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 6.46 CHEMBL

External reference:

IDSource
R16CO5Y76E UNII
4017536 VUID
N0000145918 NUI
D00109 KEGG_DRUG
1466-82-6 SECONDARY_CAS_RN
C0004057 UMLSCUI
CHEBI:15365 CHEBI
AIN PDB_CHEM_ID
CHEMBL25 ChEMBL_ID
2244 PUBCHEM_CID
DB00945 DRUGBANK_ID
D001241 MESH_DESCRIPTOR_UI
4139 IUPHAR_LIGAND_ID
1191 RXNORM
244 MMSL
34512 MMSL
4223 MMSL
d00170 MMSL
001587 NDDF
387458008 SNOMEDCT_US
7947003 SNOMEDCT_US
4017536 VANDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Fiorinal with Codeine HUMAN PRESCRIPTION DRUG LABEL 4 0023-6010 CAPSULE 325 mg ORAL NDA 36 sections
Fiorinal HUMAN PRESCRIPTION DRUG LABEL 3 0023-6146 CAPSULE 325 mg ORAL NDA 23 sections
ExcedrinExtra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-2000 TABLET, FILM COATED 250 mg ORAL OTC monograph not final 13 sections
ExcedrinExtra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-2001 TABLET, FILM COATED 250 mg ORAL OTC monograph not final 15 sections
ExcedrinExtra Strength Geltabs HUMAN OTC DRUG LABEL 3 0067-2021 TABLET, COATED 250 mg ORAL OTC monograph not final 14 sections
ExcedrinMigraine Geltabs HUMAN OTC DRUG LABEL 3 0067-2035 TABLET, COATED 250 mg ORAL NDA 14 sections
EXCEDRINMIGRAINE HUMAN OTC DRUG LABEL 3 0067-2039 TABLET, FILM COATED 250 mg ORAL NDA 15 sections
ExcedrinMigraine HUMAN OTC DRUG LABEL 3 0067-2040 TABLET, FILM COATED 250 mg ORAL NDA 16 sections
Excedrin PM Triple Action Caplets HUMAN OTC DRUG LABEL 3 0067-2056 TABLET, COATED 250 mg ORAL OTC monograph not final 16 sections
EXCEDRINMIGRAINE HUMAN OTC DRUG LABEL 3 0067-8201 TABLET, FILM COATED 250 mg ORAL NDA 15 sections
ExcedrinExtra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-8202 TABLET, FILM COATED 250 mg ORAL OTC monograph not final 15 sections
ExcedrinExtra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-8203 TABLET, FILM COATED 250 mg ORAL OTC monograph not final 15 sections
Aspirin and Dipyridamole HUMAN PRESCRIPTION DRUG LABEL 2 0093-3064 CAPSULE, EXTENDED RELEASE 25 mg ORAL ANDA 27 sections
good sense aspirin HUMAN OTC DRUG LABEL 1 0113-0259 TABLET, CHEWABLE 81 mg ORAL OTC monograph not final 15 sections
Good Sense aspirin HUMAN OTC DRUG LABEL 1 0113-0274 TABLET, CHEWABLE 81 mg ORAL OTC monograph not final 15 sections
good sense migraine formula HUMAN OTC DRUG LABEL 3 0113-0374 TABLET, FILM COATED 250 mg ORAL ANDA 15 sections
good sense aspirin HUMAN OTC DRUG LABEL 1 0113-0416 TABLET, FILM COATED 325 mg ORAL OTC monograph not final 15 sections
good sense aspirin HUMAN OTC DRUG LABEL 1 0113-0467 TABLET, CHEWABLE 81 mg ORAL OTC monograph not final 15 sections
Basic Care Aspirin HUMAN OTC DRUG LABEL 1 0113-0773 TABLET, FILM COATED 325 mg ORAL OTC monograph not final 15 sections
Good Sense Aspirin HUMAN OTC DRUG LABEL 1 0113-1919 TABLET, FILM COATED 325 mg ORAL OTC monograph not final 14 sections
basic care migraine relief HUMAN OTC DRUG LABEL 3 0113-7374 TABLET, FILM COATED 250 mg ORAL ANDA 15 sections
basic care aspirin HUMAN OTC DRUG LABEL 1 0113-7467 TABLET, CHEWABLE 81 mg ORAL OTC monograph not final 15 sections
Alka-Seltzer Plus Severe Cold PowerFast FizzOrange Zest HUMAN OTC DRUG LABEL 3 0280-0020 TABLET, EFFERVESCENT 325 mg ORAL OTC monograph final 17 sections
Alka-Seltzer Plus Severe Cold Powerfast Fizz Night HUMAN OTC DRUG LABEL 4 0280-0021 TABLET, EFFERVESCENT 500 mg ORAL OTC monograph final 16 sections
Alka-Seltzer Plus Severe Cold PowerFast Fizz Non Drowsy HUMAN OTC DRUG LABEL 3 0280-0024 TABLET, EFFERVESCENT 325 mg ORAL OTC monograph final 16 sections
BAYER 500 mg HUMAN OTC DRUG LABEL 1 0280-0029 POWDER 500 mg ORAL Export only 2 sections
Alka-Seltzer Plus Cold Sparkling Original PowerFast Fizz HUMAN OTC DRUG LABEL 3 0280-0060 TABLET, EFFERVESCENT 325 mg ORAL OTC monograph final 15 sections
Bayer Headache HUMAN OTC DRUG LABEL 2 0280-0064 TABLET 500 mg ORAL OTC monograph not final 14 sections
Alka-Seltzer Extra Strength HUMAN OTC DRUG LABEL 3 0280-0211 GRANULE, EFFERVESCENT 500 mg ORAL OTC monograph not final 17 sections
Alka-Seltzer Plus Cold Medicine Sparkling Original HUMAN OTC DRUG LABEL 3 0280-1400 TABLET, EFFERVESCENT 325 mg ORAL OTC monograph not final 17 sections