naproxcinod 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
nitrogen monoxide (nitric oxide, NO) donors 4674 163133-43-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • naproxcinod
  • nitronaproxen
  • AZD3582
a nitric oxide-releasing NSAID derivative
  • Molecular weight: 347.37
  • Formula: C18H21NO6
  • CLOGP: 4.16
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 0
  • TPSA: 90.58
  • ALOGS: -6.09
  • ROTB: 10

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 4.500 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.340 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 9.036 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 350.752 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 0.400 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 0.400 % High 1
herg hERG pIC50 5.106 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 512.861 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 263.633 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 0.580 % High 1
kinase-safety-class ACVR2A,ACVR2B,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKDC,STK33,SYK,TEK,TTK,ZAP70 47
kinase-selectivity-class AXL,BRAF,CDK9,DDR1,DYRK1B,EPHB4,GRK2,MAP2K6,MAPK7,PDK4,PRKDC,STK33,TEK,TTK 14
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.564 High 1
mh-clint Mouse hepatocyte intrinsic clearance 450.817 High 1
mppb Mouse plasma protein binding (% unbound) 0.570 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.785 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 1.560 % High 1
rh-clint Rat hepatocyte intrinsic clearance 269.153 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 5.270 % High 1
rppb Rat plasma protein binding (% unbound) 0.420 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 1.371 uM High 1

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M01AE18 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Propionic acid derivatives
MeSH PA D002317 Cardiovascular Agents
MeSH PA D020030 Nitric Oxide Donors
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
CHEBI has role CHEBI:35481 non-narcotic analgesic
CHEBI has role CHEBI:35544 EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
CHEBI has role CHEBI:50266 prodrug
CHEBI has role CHEBI:50566 nitric oxide donor

Related Drugs by ATC class:

M01AE Propionic acid derivatives 21 drugs
alminoprofenbenoxaprofendexibuprofendexketoprofendiphenhydramineesomeprazolefenbufenfenoprofenflunoxaprofenflurbiprofenibuprofenibuproxam show all 21 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D09568 KEGG_DRUG
CHEBI:76254 CHEBI
CHEMBL2103831 ChEMBL_ID
C111751 MESH_SUPPLEMENTAL_RECORD_UI
9551 IUPHAR_LIGAND_ID
8673 INN_ID
DB06682 DRUGBANK_ID
V24GR4LI3I UNII
C0673815 UMLSCUI
9884642 PUBCHEM_CID
C094069 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None