butaperazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
443 653-03-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • butaperazine
  • butyrylperazine
  • emerex
  • megalectil
  • randolectil
  • Molecular weight: 409.59
  • Formula: C24H31N3OS
  • CLOGP: 4.50
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 26.79
  • ALOGS: -4.60
  • ROTB: 7

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 3.781 Moderate 0.66
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.521 Moderate 0.66
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 16.634 10^-6 cm/s Moderate 0.66
dh-clint Dog hepatocyte intrinsic clearance 35.400 uL/min/10^6 cells Moderate 0.66
dppb Dog plasma protein binding (% unbound) 1.430 % Moderate 0.66
fcs-ppb Fetal calf serum protein binding (% unbound) 3.920 % Moderate 0.66
herg hERG pIC50 5.882 pIC50 Moderate 0.66
hh-clint Human hepatocyte intrinsic clearance 20.654 uL/min/10^6 cells Moderate 0.66
hlm-clint Human liver microsomal intrinsic clearance 53.211 uL/min/mg protein Moderate 0.66
hppb Human plasma protein binding (% unbound) 1.410 % Moderate 0.66
kinase-safety-class ACVR2A,ACVR2B,AKT1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,INSR,ITK,JAK1,JAK2,JAK3,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1 59
kinase-selectivity-class AXL,EPHB4,PDK4,STK33,TEK 5
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.750 Moderate 0.66
mh-clint Mouse hepatocyte intrinsic clearance 173.780 Moderate 0.66
mppb Mouse plasma protein binding (% unbound) 1.690 Moderate 0.66
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 7.345 Moderate 0.66
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 4.690 % Moderate 0.66
rh-clint Rat hepatocyte intrinsic clearance 188.799 uL/min/10^6 cells Moderate 0.66
rh-fuinc Rat hepatocyte fraction unbound in incubation 9.110 % Moderate 0.66
rppb Rat plasma protein binding (% unbound) 1.510 % Moderate 0.66
solubility-dd Solubility at pH 7.4 in DMSO 78.524 uM Moderate 0.66

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05AB09 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Phenothiazines with piperazine structure
CHEBI has role CHEBI:35476 antipsychotic agent

Related Drugs by ATC class:

N05AB Phenothiazines with piperazine structure 9 drugs
acetophenazinedixyrazinefluphenazineperazineperphenazineprochlorperazinethiopropazatethioproperazinetrifluoperazine

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.74 Basic
pKa2 4.74 Basic
pKa3 1.51 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D02642 KEGG_DRUG
C0006481 UMLSCUI
CHEBI:135663 CHEBI
CHEMBL1697826 ChEMBL_ID
DB13213 DRUGBANK_ID
C084595 MESH_SUPPLEMENTAL_RECORD_UI
12598 PUBCHEM_CID
1432 INN_ID
TXP4T9106S UNII
75645006 SNOMEDCT_US
001526 NDDF

Pharmaceutical products:

None