Stem definition | Drug id | CAS RN |
---|---|---|
59 | 2751-68-0 |
Dose | Unit | Route |
---|---|---|
50 | mg | O |
None
Date | Agency | Company | Orphan |
---|---|---|---|
April 5, 1961 | FDA | SCHERING |
None
None
None
None
Source | Code | Description |
---|---|---|
ATC | N05AB07 | NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Phenothiazines with piperazine structure |
CHEBI has role | CHEBI:37930 | phenothiazine antipsychotic drugs |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Psychotic disorder | indication | 69322001 | |
Alcoholism | contraindication | 7200002 | |
Organophosphate poisoning | contraindication | 8260003 | |
Weight gain finding | contraindication | 8943002 | |
Neuroleptic malignant syndrome | contraindication | 15244003 | DOID:14464 |
Senile dementia | contraindication | 15662003 | |
Chronic disease of respiratory system | contraindication | 17097001 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Glaucoma | contraindication | 23986001 | DOID:1686 |
Orthostatic hypotension | contraindication | 28651003 | |
Torsades de pointes | contraindication | 31722008 | |
Parkinsonism | contraindication | 32798002 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Chronic heart failure | contraindication | 48447003 | |
Bradycardia | contraindication | 48867003 | |
Extrapyramidal disease | contraindication | 76349003 | |
Hyperglycemia | contraindication | 80394007 | DOID:4195 |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Leukopenia | contraindication | 84828003 | DOID:615 |
Stupor | contraindication | 89458003 | |
Tardive dyskinesia | contraindication | 102449007 | |
Prolonged QT interval | contraindication | 111975006 | |
Acute disease of cardiovascular system | contraindication | 128487001 | |
Angina pectoris | contraindication | 194828000 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Metabolic syndrome X | contraindication | 237602007 | DOID:14221 |
Hyperprolactinemia | contraindication | 237662005 | DOID:12700 |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Retention of urine | contraindication | 267064002 | |
Anemia | contraindication | 271737000 | DOID:2355 |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Coma | contraindication | 371632003 | |
At risk for aspiration | contraindication | 371736008 | |
Visual impairment | contraindication | 397540003 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
Obesity | contraindication | 414916001 | DOID:9970 |
Congenital long QT syndrome | contraindication | 442917000 | |
Carcinoma of female breast | contraindication | 447782002 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.21 | Basic |
pKa2 | 4.21 | Basic |
pKa3 | 1.82 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
D(2) dopamine receptor | GPCR | ANTAGONIST | DRUGBANK | CHEMBL | |||||
Androgen receptor | Transcription factor | Ki | 6.10 | CHEMBL |
ID | Source |
---|---|
4019593 | VUID |
N0000179028 | NUI |
D00788 | KEGG_DRUG |
5714-00-1 | SECONDARY_CAS_RN |
16735 | RXNORM |
C0050458 | UMLSCUI |
CHEBI:2401 | CHEBI |
CHEMBL1085 | ChEMBL_ID |
DB01063 | DRUGBANK_ID |
C100162 | MESH_SUPPLEMENTAL_RECORD_UI |
17676 | PUBCHEM_CID |
1026 | INN_ID |
8620H6K4QH | UNII |
35281007 | SNOMEDCT_US |
67029008 | SNOMEDCT_US |
CHEMBL2360079 | ChEMBL_ID |
4018806 | VANDF |
4019593 | VANDF |
001485 | NDDF |
004592 | NDDF |
None