thioproperazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
2635 316-81-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • thioproperazine
  • sulfenazin
  • thioperazine
  • tioproperazin
  • thioproperazine dimesylate
  • thioproperazine mesylate
  • thioproperazine mesyiate
  • thioproperazine mesilate
  • Molecular weight: 446.63
  • Formula: C22H30N4O2S2
  • CLOGP: 2.31
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 0
  • TPSA: 47.10
  • ALOGS: -3.89
  • ROTB: 5

Drug dosage:

DoseUnitRoute
75 mg O
20 mg P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 2.520 Moderate 0.66
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.734 Moderate 0.66
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 20.941 10^-6 cm/s Moderate 0.66
dh-clint Dog hepatocyte intrinsic clearance 48.195 uL/min/10^6 cells Moderate 0.66
dppb Dog plasma protein binding (% unbound) 8.980 % Moderate 0.66
fcs-ppb Fetal calf serum protein binding (% unbound) 15.880 % Moderate 0.66
herg hERG pIC50 5.929 pIC50 Moderate 0.66
hh-clint Human hepatocyte intrinsic clearance 14.962 uL/min/10^6 cells Moderate 0.66
hlm-clint Human liver microsomal intrinsic clearance 136.144 uL/min/mg protein Moderate 0.66
hppb Human plasma protein binding (% unbound) 7.550 % Moderate 0.66
kinase-safety-class ACVR2B,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP3K7,MAPK10,MAPK7,MAPKAPK2,MET,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKDC,SIK2,SIK3,STK33,TEK,TGFBR1,TTK 40
kinase-selectivity-class AXL 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 4.797 Moderate 0.66
mh-clint Mouse hepatocyte intrinsic clearance 208.930 Moderate 0.66
mppb Mouse plasma protein binding (% unbound) 8.550 Moderate 0.66
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 22.961 Moderate 0.66
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 26.820 % Moderate 0.66
rh-clint Rat hepatocyte intrinsic clearance 244.343 uL/min/10^6 cells Moderate 0.66
rh-fuinc Rat hepatocyte fraction unbound in incubation 39.230 % Moderate 0.66
rppb Rat plasma protein binding (% unbound) 8.390 % Moderate 0.66
solubility-dd Solubility at pH 7.4 in DMSO 548.277 uM Moderate 0.66

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05AB08 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Phenothiazines with piperazine structure
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:37930 phenothiazine antipsychotic drug

Related Drugs by ATC class:

N05AB Phenothiazines with piperazine structure 9 drugs
acetophenazinebutaperazinedixyrazinefluphenazineperazineperphenazineprochlorperazinethiopropazatetrifluoperazine

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.74 Basic
pKa2 4.74 Basic
pKa3 3.06 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
D(2) dopamine receptor GPCR Ki 9.35 PDSP
D(3) dopamine receptor GPCR Ki 8.92 PDSP

External reference:

IDSource
D01447 KEGG_DRUG
C0039936 UMLSCUI
CHEBI:59120 CHEBI
CHEMBL609109 ChEMBL_ID
DB01622 DRUGBANK_ID
C084825 MESH_SUPPLEMENTAL_RECORD_UI
911 INN_ID
2347-80-0 SECONDARY_CAS_RN
YJ050AQ56X UNII
9429 PUBCHEM_CID
10498 RXNORM
003494 NDDF
003495 NDDF
CHEMBL1481539 ChEMBL_ID
YJ050AQ56X INXIGHT DRUGS

Pharmaceutical products:

None