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| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2113 | 58-39-9 |
| Dose | Unit | Route |
|---|---|---|
| 30 | mg | O |
| 7 | mg | P |
| 10 | mg | P |
| 16 | mg | R |
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.99 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 40 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 18 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 27 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.07 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 9.40 hours | Lombardo F, Berellini G, Obach RS |
| S (Water solubility) | 0.02 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Bocci G, Oprea TI, Benet LZ |
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 3.459 | High | 1 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 0.918 | High | 1 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 25.645 | 10^-6 cm/s | High | 1 |
| dh-clint | Dog hepatocyte intrinsic clearance | 41.400 | uL/min/10^6 cells | High | 1 |
| dppb | Dog plasma protein binding (% unbound) | 2.290 | % | High | 1 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 4.520 | % | High | 1 |
| herg | hERG pIC50 | 5.930 | pIC50 | High | 1 |
| hh-clint | Human hepatocyte intrinsic clearance | 28.907 | uL/min/10^6 cells | High | 1 |
| hlm-clint | Human liver microsomal intrinsic clearance | 58.614 | uL/min/mg protein | High | 1 |
| hppb | Human plasma protein binding (% unbound) | 1.610 | % | High | 1 |
| kinase-safety-class | ACVR2A,ACVR2B,AKT1,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MET,MTOR,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK | 48 | |||
| kinase-selectivity-class | AXL,EPHB4,PDK4,SIK2 | 4 | |||
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 3.776 | High | 1 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 162.181 | High | 1 | |
| mppb | Mouse plasma protein binding (% unbound) | 2.550 | High | 1 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 9.376 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 7.490 | % | High | 1 |
| rh-clint | Rat hepatocyte intrinsic clearance | 254.097 | uL/min/10^6 cells | High | 1 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 14.920 | % | High | 1 |
| rppb | Rat plasma protein binding (% unbound) | 1.970 | % | High | 1 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 52.723 | uM | High | 1 |
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Feb. 27, 1957 | FDA |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Tardive dyskinesia | 303.24 | 29.18 | 76 | 4280 | 10854 | 90613237 |
| Dystonia | 252.63 | 29.18 | 72 | 4284 | 16747 | 90607344 |
| Parkinsonism | 232.94 | 29.18 | 65 | 4291 | 14000 | 90610091 |
| Dyskinesia | 186.58 | 29.18 | 69 | 4287 | 36465 | 90587626 |
| Myoclonus | 167.08 | 29.18 | 54 | 4302 | 19114 | 90604977 |
| Apraxia | 155.84 | 29.18 | 33 | 4323 | 2229 | 90621862 |
| Creatinine renal clearance increased | 143.62 | 29.18 | 33 | 4323 | 3248 | 90620843 |
| Renal function test abnormal | 141.11 | 29.18 | 38 | 4318 | 7153 | 90616938 |
| Drug abuse | 135.56 | 29.18 | 70 | 4286 | 82277 | 90541814 |
| Head titubation | 125.55 | 29.18 | 25 | 4331 | 1243 | 90622848 |
| Sedation complication | 116.76 | 29.18 | 40 | 4316 | 16904 | 90607187 |
| Creatinine renal clearance decreased | 104.95 | 29.18 | 38 | 4318 | 18861 | 90605230 |
| Multiple drug therapy | 91.78 | 29.18 | 27 | 4329 | 6982 | 90617109 |
| Sedation | 91.05 | 29.18 | 45 | 4311 | 48126 | 90575965 |
| Blood calcium decreased | 87.70 | 29.18 | 38 | 4318 | 30144 | 90593947 |
| Polydipsia | 86.01 | 29.18 | 23 | 4333 | 4208 | 90619883 |
| Orthostatic hypotension | 81.80 | 29.18 | 40 | 4316 | 41787 | 90582304 |
| Depressed level of consciousness | 81.44 | 29.18 | 48 | 4308 | 72736 | 90551355 |
| Blood magnesium increased | 81.14 | 29.18 | 21 | 4335 | 3387 | 90620704 |
| Pleural fibrosis | 80.02 | 29.18 | 21 | 4335 | 3575 | 90620516 |
| Presbyacusis | 78.56 | 29.18 | 20 | 4336 | 3022 | 90621069 |
| Overdose | 78.34 | 29.18 | 63 | 4293 | 157646 | 90466445 |
| Pleural thickening | 77.26 | 29.18 | 20 | 4336 | 3228 | 90620863 |
| Neuroleptic malignant syndrome | 71.45 | 29.18 | 27 | 4329 | 15069 | 90609022 |
| Hyperprolactinaemia | 71.44 | 29.18 | 21 | 4335 | 5412 | 90618679 |
| Movement disorder | 66.63 | 29.18 | 31 | 4325 | 28988 | 90595103 |
| Toxicity to various agents | 66.04 | 29.18 | 75 | 4281 | 287771 | 90336320 |
| Extrapyramidal disorder | 65.91 | 29.18 | 26 | 4330 | 16277 | 90607814 |
| Cognitive disorder | 62.86 | 29.18 | 40 | 4316 | 69367 | 90554724 |
| Deafness neurosensory | 62.53 | 29.18 | 20 | 4336 | 6821 | 90617270 |
| Drug interaction | 61.66 | 29.18 | 71 | 4285 | 276382 | 90347709 |
| Epigastric discomfort | 60.55 | 29.18 | 20 | 4336 | 7548 | 90616543 |
| Sopor | 58.68 | 29.18 | 27 | 4329 | 24617 | 90599474 |
| Balance disorder | 48.61 | 29.18 | 39 | 4317 | 97041 | 90527050 |
| Cyst | 48.57 | 29.18 | 21 | 4335 | 16540 | 90607551 |
| Blood potassium increased | 44.04 | 29.18 | 21 | 4335 | 20728 | 90603363 |
| Tremor | 43.99 | 29.18 | 45 | 4311 | 153128 | 90470963 |
| Mitochondrial encephalomyopathy | 43.66 | 29.18 | 7 | 4349 | 98 | 90623993 |
| Ileus paralytic | 42.94 | 29.18 | 14 | 4342 | 5071 | 90619020 |
| Osteopenia | 41.98 | 29.18 | 21 | 4335 | 22981 | 90601110 |
| Bone cyst | 34.84 | 29.18 | 10 | 4346 | 2368 | 90621723 |
| Hyponatraemia | 34.34 | 29.18 | 37 | 4319 | 133501 | 90490590 |
| Deformity | 34.27 | 29.18 | 15 | 4341 | 12155 | 90611936 |
| Osteosclerosis | 32.89 | 29.18 | 11 | 4345 | 4309 | 90619782 |
| Moaning | 32.64 | 29.18 | 8 | 4348 | 1035 | 90623056 |
| Hypotension | 32.55 | 29.18 | 57 | 4299 | 325340 | 90298751 |
| Skin lesion | 32.48 | 29.18 | 21 | 4335 | 37344 | 90586747 |
| Mobility decreased | 30.54 | 29.18 | 48 | 4308 | 250686 | 90373405 |
| Onychophagia | 30.50 | 29.18 | 5 | 4351 | 81 | 90624010 |
| Bladder disorder | 29.44 | 29.18 | 13 | 4343 | 10759 | 90613332 |
| Intentional self-injury | 29.29 | 29.18 | 18 | 4338 | 29316 | 90594775 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Antipsychotic drug level below therapeutic | 581.27 | 47.07 | 114 | 3356 | 3090 | 42614775 |
| Akathisia | 567.85 | 47.07 | 138 | 3332 | 10313 | 42607552 |
| Therapeutic product effect variable | 560.19 | 47.07 | 110 | 3360 | 2999 | 42614866 |
| Disinhibition | 559.06 | 47.07 | 114 | 3356 | 3781 | 42614084 |
| Obsessive-compulsive disorder | 539.95 | 47.07 | 122 | 3348 | 6621 | 42611244 |
| Euphoric mood | 512.55 | 47.07 | 116 | 3354 | 6337 | 42611528 |
| Increased appetite | 465.17 | 47.07 | 114 | 3356 | 8792 | 42609073 |
| Suicide attempt | 329.77 | 47.07 | 128 | 3342 | 45972 | 42571893 |
| Leukaemia | 261.45 | 47.07 | 66 | 3404 | 5706 | 42612159 |
| Therapeutic product effect incomplete | 224.50 | 47.07 | 111 | 3359 | 70828 | 42547037 |
| Weight increased | 212.22 | 47.07 | 123 | 3347 | 107860 | 42510005 |
| Dyslipidaemia | 211.66 | 47.07 | 62 | 3408 | 9356 | 42608509 |
| Leukopenia | 210.23 | 47.07 | 108 | 3362 | 74638 | 42543227 |
| Toxicity to various agents | 196.73 | 47.07 | 156 | 3314 | 228980 | 42388885 |
| Obesity | 173.77 | 47.07 | 61 | 3409 | 16398 | 42601467 |
| Prescribed overdose | 160.10 | 47.07 | 54 | 3416 | 12873 | 42604992 |
| Schizoaffective disorder | 116.82 | 47.07 | 28 | 3442 | 1942 | 42615923 |
| Irritability | 91.57 | 47.07 | 45 | 3425 | 28083 | 42589782 |
| Neuroleptic malignant syndrome | 77.87 | 47.07 | 37 | 3433 | 21435 | 42596430 |
| Drug ineffective | 75.03 | 47.07 | 160 | 3310 | 630037 | 41987828 |
| Product use in unapproved indication | 50.13 | 47.07 | 68 | 3402 | 184388 | 42433477 |
| Hypertension | 47.49 | 47.07 | 63 | 3407 | 167141 | 42450724 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Akathisia | 226.74 | 30.71 | 69 | 6186 | 17044 | 110566000 |
| Tardive dyskinesia | 224.59 | 30.71 | 65 | 6190 | 13514 | 110569530 |
| Antipsychotic drug level below therapeutic | 200.64 | 30.71 | 40 | 6215 | 1695 | 110581349 |
| Therapeutic product effect variable | 188.32 | 30.71 | 41 | 6214 | 2677 | 110580367 |
| Disinhibition | 177.07 | 30.71 | 40 | 6215 | 3094 | 110579950 |
| Dystonia | 168.44 | 30.71 | 61 | 6194 | 25744 | 110557300 |
| Parkinsonism | 165.85 | 30.71 | 58 | 6197 | 22129 | 110560915 |
| Obsessive-compulsive disorder | 153.02 | 30.71 | 42 | 6213 | 7199 | 110575845 |
| Euphoric mood | 144.79 | 30.71 | 42 | 6213 | 8785 | 110574259 |
| Creatinine renal clearance increased | 134.97 | 30.71 | 33 | 6222 | 3592 | 110579452 |
| Toxicity to various agents | 134.62 | 30.71 | 150 | 6105 | 480405 | 110102639 |
| Neuroleptic malignant syndrome | 131.50 | 30.71 | 55 | 6200 | 34004 | 110549040 |
| Dyskinesia | 130.85 | 30.71 | 62 | 6193 | 51384 | 110531660 |
| Renal function test abnormal | 126.73 | 30.71 | 38 | 6217 | 8908 | 110574136 |
| Apraxia | 125.59 | 30.71 | 31 | 6224 | 3509 | 110579535 |
| Head titubation | 125.59 | 30.71 | 26 | 6229 | 1331 | 110581713 |
| Dyslipidaemia | 120.31 | 30.71 | 42 | 6213 | 15923 | 110567121 |
| Increased appetite | 115.16 | 30.71 | 40 | 6215 | 14937 | 110568107 |
| Schizoaffective disorder | 108.92 | 30.71 | 27 | 6228 | 3109 | 110579935 |
| Sedation complication | 107.75 | 30.71 | 41 | 6214 | 19814 | 110563230 |
| Sedation | 96.77 | 30.71 | 56 | 6199 | 69627 | 110513417 |
| Creatinine renal clearance decreased | 93.59 | 30.71 | 38 | 6217 | 21777 | 110561267 |
| Hyperprolactinaemia | 93.43 | 30.71 | 28 | 6227 | 6547 | 110576497 |
| Drug abuse | 88.26 | 30.71 | 76 | 6179 | 177335 | 110405709 |
| Myoclonus | 87.66 | 30.71 | 41 | 6214 | 32957 | 110550087 |
| Blood calcium decreased | 84.43 | 30.71 | 41 | 6214 | 35804 | 110547240 |
| Multiple drug therapy | 83.86 | 30.71 | 27 | 6228 | 7987 | 110575057 |
| Irritability | 78.79 | 30.71 | 43 | 6212 | 47766 | 110535278 |
| Presbyacusis | 76.83 | 30.71 | 20 | 6235 | 2799 | 110580245 |
| Suicide attempt | 76.57 | 30.71 | 56 | 6199 | 103338 | 110479706 |
| Blood magnesium increased | 75.35 | 30.71 | 21 | 6234 | 3802 | 110579242 |
| Pleural thickening | 73.12 | 30.71 | 20 | 6235 | 3379 | 110579665 |
| Extrapyramidal disorder | 70.94 | 30.71 | 34 | 6221 | 28833 | 110554211 |
| Orthostatic hypotension | 70.74 | 30.71 | 45 | 6210 | 66204 | 110516840 |
| Polydipsia | 68.75 | 30.71 | 23 | 6232 | 7665 | 110575379 |
| Pleural fibrosis | 68.43 | 30.71 | 20 | 6235 | 4288 | 110578756 |
| Completed suicide | 68.18 | 30.71 | 76 | 6179 | 242305 | 110340739 |
| Leukaemia | 65.28 | 30.71 | 22 | 6233 | 7496 | 110575548 |
| Overdose | 56.82 | 30.71 | 68 | 6187 | 233726 | 110349318 |
| Depressed level of consciousness | 55.58 | 30.71 | 48 | 6207 | 112230 | 110470814 |
| Movement disorder | 55.19 | 30.71 | 31 | 6224 | 36373 | 110546671 |
| Epigastric discomfort | 53.93 | 30.71 | 20 | 6235 | 8995 | 110574049 |
| Drug interaction | 53.70 | 30.71 | 99 | 6156 | 500084 | 110082960 |
| Cognitive disorder | 52.87 | 30.71 | 42 | 6213 | 87469 | 110495575 |
| Deafness neurosensory | 52.66 | 30.71 | 20 | 6235 | 9599 | 110573445 |
| Enuresis | 52.01 | 30.71 | 16 | 6239 | 4080 | 110578964 |
| Ileus paralytic | 48.80 | 30.71 | 20 | 6235 | 11717 | 110571327 |
| Product use in unapproved indication | 48.56 | 30.71 | 89 | 6166 | 447288 | 110135756 |
| Obesity | 47.28 | 30.71 | 44 | 6211 | 113307 | 110469737 |
| Sopor | 47.09 | 30.71 | 28 | 6227 | 36518 | 110546526 |
| Cyst | 45.36 | 30.71 | 21 | 6234 | 16475 | 110566569 |
| Prescribed overdose | 44.47 | 30.71 | 38 | 6217 | 87543 | 110495501 |
| Balance disorder | 42.47 | 30.71 | 42 | 6213 | 116518 | 110466526 |
| Leukopenia | 42.38 | 30.71 | 47 | 6208 | 148744 | 110434300 |
| Mitochondrial encephalomyopathy | 41.70 | 30.71 | 7 | 6248 | 111 | 110582933 |
| Intentional self-injury | 41.37 | 30.71 | 26 | 6229 | 37403 | 110545641 |
| Tremor | 39.84 | 30.71 | 53 | 6202 | 202179 | 110380865 |
| Osteopenia | 36.64 | 30.71 | 20 | 6235 | 22189 | 110560855 |
| Weight increased | 32.95 | 30.71 | 73 | 6182 | 419571 | 110163473 |
| Muscle rigidity | 32.50 | 30.71 | 19 | 6236 | 24012 | 110559032 |
| Salivary hypersecretion | 32.42 | 30.71 | 17 | 6238 | 17404 | 110565640 |
| Blood potassium increased | 31.58 | 30.71 | 21 | 6234 | 33228 | 110549816 |
| Deformity | 31.29 | 30.71 | 14 | 6241 | 10146 | 110572898 |
| Constipation | 31.25 | 30.71 | 65 | 6190 | 357721 | 110225323 |
None
| Source | Code | Description |
|---|---|---|
| ATC | N05AB03 | NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Phenothiazines with piperazine structure |
| FDA CS | M0016525 | Phenothiazines |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D011619 | Psychotropic Drugs |
| MeSH PA | D014150 | Antipsychotic Agents |
| MeSH PA | D015259 | Dopamine Agents |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018492 | Dopamine Antagonists |
| FDA EPC | N0000175746 | Phenothiazine |
| CHEBI has role | CHEBI:35469 | antidepressant |
| CHEBI has role | CHEBI:35474 | anxiolytic drug |
| CHEBI has role | CHEBI:35476 | antipsychotic agent |
| CHEBI has role | CHEBI:37930 | phenothiazine antipsychotic drug |
| CHEBI has role | CHEBI:48561 | dopaminergic antagonist |
| CHEBI has role | CHEBI:50919 | antiemetic |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Nausea and vomiting | indication | 16932000 | |
| Schizophrenia | indication | 58214004 | DOID:5419 |
| Mixed anxiety and depressive disorder | indication | 231504006 | |
| Suicidal thoughts | contraindication | 6471006 | |
| Alcoholism | contraindication | 7200002 | |
| Organophosphate poisoning | contraindication | 8260003 | |
| Weight gain finding | contraindication | 8943002 | |
| Sinus tachycardia | contraindication | 11092001 | |
| Neuroleptic malignant syndrome | contraindication | 15244003 | DOID:14464 |
| Senile dementia | contraindication | 15662003 | |
| Chronic disease of respiratory system | contraindication | 17097001 | |
| Myocardial infarction | contraindication | 22298006 | DOID:5844 |
| Glaucoma | contraindication | 23986001 | DOID:1686 |
| Orthostatic hypotension | contraindication | 28651003 | |
| Torsades de pointes | contraindication | 31722008 | |
| Parkinsonism | contraindication | 32798002 | |
| Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Chronic heart failure | contraindication | 48447003 | |
| Bradycardia | contraindication | 48867003 | |
| Paralytic ileus | contraindication | 55525008 | DOID:8442 |
| Extrapyramidal disease | contraindication | 76349003 | |
| Hyperglycemia | contraindication | 80394007 | DOID:4195 |
| Chronic idiopathic constipation | contraindication | 82934008 | |
| Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
| Epilepsy | contraindication | 84757009 | DOID:1826 |
| Leukopenia | contraindication | 84828003 | DOID:615 |
| Stupor | contraindication | 89458003 | |
| Tardive dyskinesia | contraindication | 102449007 | |
| Prolonged QT interval | contraindication | 111975006 | |
| Acute disease of cardiovascular system | contraindication | 128487001 | |
| Bipolar affective disorder, current episode manic | contraindication | 191618007 | |
| Angina pectoris | contraindication | 194828000 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Metabolic syndrome X | contraindication | 237602007 | DOID:14221 |
| Hyperprolactinemia | contraindication | 237662005 | DOID:12700 |
| Benign prostatic hyperplasia | contraindication | 266569009 | |
| Retention of urine | contraindication | 267064002 | |
| Syncope | contraindication | 271594007 | |
| Anemia | contraindication | 271737000 | DOID:2355 |
| Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
| Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
| Coma | contraindication | 371632003 | |
| At risk for aspiration | contraindication | 371736008 | |
| Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
| Visual impairment | contraindication | 397540003 | |
| Breastfeeding (mother) | contraindication | 413712001 | |
| Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
| Obesity | contraindication | 414916001 | DOID:9970 |
| Myocardial infarction in recovery phase | contraindication | 418044006 | |
| Congenital long QT syndrome | contraindication | 442917000 | |
| Carcinoma of female breast | contraindication | 447782002 |
None
None
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.21 | Basic |
| pKa2 | 4.21 | Basic |
| pKa3 | 2.21 | Basic |
None
None
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| D(2) dopamine receptor | GPCR | ANTAGONIST | Ki | 9.32 | WOMBAT-PK | CHEMBL | |||
| Alpha-2A adrenergic receptor | GPCR | Ki | 6.19 | WOMBAT-PK | |||||
| Potassium voltage-gated channel subfamily H member 2 | Ion channel | Ki | 5.46 | DRUG MATRIX | |||||
| 5-hydroxytryptamine receptor 1A | GPCR | Ki | 6.07 | WOMBAT-PK | |||||
| 5-hydroxytryptamine receptor 2A | GPCR | Ki | 8.25 | WOMBAT-PK | |||||
| 5-hydroxytryptamine receptor 2C | GPCR | Ki | 6.88 | WOMBAT-PK | |||||
| 5-hydroxytryptamine receptor 6 | GPCR | Ki | 7.55 | WOMBAT-PK | |||||
| 5-hydroxytryptamine receptor 7 | GPCR | Ki | 7.64 | WOMBAT-PK | |||||
| Alpha-1A adrenergic receptor | GPCR | Ki | 8 | WOMBAT-PK | |||||
| Alpha-2B adrenergic receptor | GPCR | Ki | 6.98 | WOMBAT-PK | |||||
| D(3) dopamine receptor | GPCR | Ki | 9.52 | WOMBAT-PK | |||||
| Histamine H1 receptor | GPCR | Ki | 8.09 | WOMBAT-PK | |||||
| Muscarinic acetylcholine receptor M3 | GPCR | Ki | 5.73 | PDSP | |||||
| Aldehyde oxidase | Enzyme | IC50 | 7.48 | WOMBAT-PK | |||||
| Alpha-2C adrenergic receptor | GPCR | Ki | 7.07 | WOMBAT-PK | |||||
| D(4) dopamine receptor | GPCR | Ki | 7.59 | WOMBAT-PK | |||||
| Retinal dehydrogenase 1 | Enzyme | IC50 | 6.28 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 7 | GPCR | ANTAGONIST | Ki | 7.60 | IUPHAR | ||||
| 5-hydroxytryptamine receptor 6 | GPCR | ANTAGONIST | Ki | 7.80 | IUPHAR | ||||
| Pleiotropic ABC efflux transporter of multiple drugs | Transporter | IC50 | 5.85 | CHEMBL |
| ID | Source |
|---|---|
| 4017939 | VUID |
| N0000146289 | NUI |
| D00503 | KEGG_DRUG |
| 4017939 | VANDF |
| C0031184 | UMLSCUI |
| CHEBI:8028 | CHEBI |
| CHEMBL567 | ChEMBL_ID |
| D010546 | MESH_DESCRIPTOR_UI |
| DB00850 | DRUGBANK_ID |
| 4748 | PUBCHEM_CID |
| 209 | IUPHAR_LIGAND_ID |
| 637 | INN_ID |
| FTA7XXY4EZ | UNII |
| 8076 | RXNORM |
| 2271 | MMSL |
| 5261 | MMSL |
| d00855 | MMSL |
| 001477 | NDDF |
| 387229007 | SNOMEDCT_US |
| 41147003 | SNOMEDCT_US |
| FTA7XXY4EZ | INXIGHT DRUGS |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Perphenazine and Amitriptyline Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-0042 | TABLET, FILM COATED | 4 mg | ORAL | ANDA | 19 sections |
| Perphenazine and Amitriptyline Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-0073 | TABLET, FILM COATED | 4 mg | ORAL | ANDA | 19 sections |
| Perphenazine and Amitriptyline Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-0330 | TABLET, FILM COATED | 2 mg | ORAL | ANDA | 19 sections |
| Perphenazine and Amitriptyline Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-0442 | TABLET, FILM COATED | 2 mg | ORAL | ANDA | 19 sections |
| Perphenazine and Amitriptyline Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-0574 | TABLET, FILM COATED | 4 mg | ORAL | ANDA | 19 sections |
| Perphenazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-4101 | TABLET, FILM COATED | 2 mg | ORAL | ANDA | 20 sections |
| Perphenazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-4102 | TABLET, FILM COATED | 4 mg | ORAL | ANDA | 20 sections |
| Perphenazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-4103 | TABLET, FILM COATED | 8 mg | ORAL | ANDA | 20 sections |
| Perphenazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-4104 | TABLET, FILM COATED | 16 mg | ORAL | ANDA | 20 sections |
| Perphenazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0603-5060 | TABLET, FILM COATED | 2 mg | ORAL | ANDA | 19 sections |
| Perphenazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0603-5061 | TABLET, FILM COATED | 4 mg | ORAL | ANDA | 19 sections |
| Perphenazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0603-5062 | TABLET, FILM COATED | 8 mg | ORAL | ANDA | 19 sections |
| Perphenazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0603-5063 | TABLET, FILM COATED | 16 mg | ORAL | ANDA | 19 sections |
| Perphenazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-8046 | TABLET, FILM COATED | 2 mg | ORAL | ANDA | 19 sections |
| Perphenazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-8047 | TABLET, FILM COATED | 4 mg | ORAL | ANDA | 19 sections |
| Perphenazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-8048 | TABLET, FILM COATED | 8 mg | ORAL | ANDA | 19 sections |
| Perphenazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-8049 | TABLET, FILM COATED | 16 mg | ORAL | ANDA | 19 sections |
| Perphenazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6599 | TABLET, FILM COATED | 2 mg | ORAL | ANDA | 19 sections |
| Perphenazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6600 | TABLET, FILM COATED | 4 mg | ORAL | ANDA | 19 sections |
| Perphenazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6601 | TABLET, FILM COATED | 8 mg | ORAL | ANDA | 19 sections |
| Perphenazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-141 | TABLET, FILM COATED | 4 mg | ORAL | ANDA | 18 sections |
| Perphenazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-415 | TABLET, FILM COATED | 8 mg | ORAL | ANDA | 18 sections |
| PERPHENAZINE | Human Prescription Drug Label | 1 | 23155-799 | TABLET | 2 mg | ORAL | ANDA | 16 sections |
| PERPHENAZINE | Human Prescription Drug Label | 1 | 23155-800 | TABLET | 4 mg | ORAL | ANDA | 16 sections |
| PERPHENAZINE | Human Prescription Drug Label | 1 | 23155-801 | TABLET | 8 mg | ORAL | ANDA | 16 sections |
| PERPHENAZINE | Human Prescription Drug Label | 1 | 23155-802 | TABLET | 16 mg | ORAL | ANDA | 16 sections |
| Perphenazine | Human Prescription Drug Label | 1 | 33342-448 | TABLET | 2 mg | ORAL | ANDA | 14 sections |
| Perphenazine | Human Prescription Drug Label | 1 | 33342-449 | TABLET | 4 mg | ORAL | ANDA | 14 sections |
| Perphenazine | Human Prescription Drug Label | 1 | 33342-450 | TABLET | 8 mg | ORAL | ANDA | 14 sections |
| Perphenazine | Human Prescription Drug Label | 1 | 33342-451 | TABLET | 16 mg | ORAL | ANDA | 14 sections |