thiopropazate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
2634 84-06-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • thiopropazate
  • perphenazine acetate
  • thiopropazat
minor descriptor (66-72); major descriptor (73-85); on-line search PHENOTHIAZINES (66-85); Index Medicus search PHENOTHIAZINES (66-72); THIOPROPAZATE (73-85); RN given refers to parent cpd
  • Molecular weight: 446.01
  • Formula: C23H28ClN3O2S
  • CLOGP: 4.91
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 0
  • TPSA: 36.02
  • ALOGS: -4.84
  • ROTB: 8

Drug dosage:

DoseUnitRoute
60 mg O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 4.283 Moderate 0.73
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.723 Moderate 0.73
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 10.447 10^-6 cm/s Moderate 0.73
dh-clint Dog hepatocyte intrinsic clearance 86.099 uL/min/10^6 cells Moderate 0.73
dppb Dog plasma protein binding (% unbound) 0.690 % Moderate 0.73
fcs-ppb Fetal calf serum protein binding (% unbound) 0.710 % Moderate 0.73
herg hERG pIC50 5.945 pIC50 Moderate 0.73
hh-clint Human hepatocyte intrinsic clearance 183.231 uL/min/10^6 cells Moderate 0.73
hlm-clint Human liver microsomal intrinsic clearance 309.742 uL/min/mg protein Moderate 0.73
hppb Human plasma protein binding (% unbound) 0.350 % Moderate 0.73
kinase-safety-class ACVR2A,ACVR2B,AKT1,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MET,MTOR,NTRK2,PAK4,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK 52
kinase-selectivity-class AXL,EPHB4,PDK4,SIK2,STK33 5
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.710 Moderate 0.73
mh-clint Mouse hepatocyte intrinsic clearance 265.461 Moderate 0.73
mppb Mouse plasma protein binding (% unbound) 1.260 Moderate 0.73
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 2.234 Moderate 0.73
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 2.900 % Moderate 0.73
rh-clint Rat hepatocyte intrinsic clearance 371.535 uL/min/10^6 cells Moderate 0.73
rh-fuinc Rat hepatocyte fraction unbound in incubation 5.370 % Moderate 0.73
rppb Rat plasma protein binding (% unbound) 0.560 % Moderate 0.73
solubility-dd Solubility at pH 7.4 in DMSO 6.561 uM Moderate 0.73

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05AB05 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Phenothiazines with piperazine structure
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:37930 phenothiazine antipsychotic drug
CHEBI has role CHEBI:48561 dopaminergic antagonist

Related Drugs by ATC class:

N05AB Phenothiazines with piperazine structure 9 drugs
acetophenazinebutaperazinedixyrazinefluphenazineperazineperphenazineprochlorperazinethioproperazinetrifluoperazine

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.85 Basic
pKa2 3.85 Basic
pKa3 2.21 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D09216 KEGG_DRUG
C0076513 UMLSCUI
CHEBI:59119 CHEBI
CHEMBL1697851 ChEMBL_ID
DB13557 DRUGBANK_ID
C100194 MESH_SUPPLEMENTAL_RECORD_UI
742 INN_ID
0JFY081Q2X UNII
6762 PUBCHEM_CID
38133 RXNORM
001487 NDDF
74713003 SNOMEDCT_US

Pharmaceutical products:

None