All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

trifluoperazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2740	117-89-5

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: trifluoperazine trifluoperazin trifluoromethylperazine trifluoroperazine trifluperazine triflurin triperazine trifluoperazine hydrochloride trifluoperazine dihydrochloride trifluoperazine HCl flupazine	A phenothiazine with actions similar to CHLORPROMAZINE. It is used as an antipsychotic and an antiemetic. Molecular weight: 407.50 Formula: C21H24F3N3S CLOGP: 4.89 LIPINSKI: 0 HAC: 3 HDO: 0 TPSA: 9.72 ALOGS: -4.67 ROTB: 5 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
20	mg	O
8	mg	P
20	mg	R

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	50 mg/mL	Benet LZ, Broccatelli F, Oprea TI

Approvals:

Date	Agency	Company	Orphan
April 16, 1959	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug abuse	69.33	49.41	24	427	72494	63416077

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Antipsychotic drug level below therapeutic	495.87	225.69	88	1545	2459	34952839
Therapeutic product effect variable	479.03	225.69	85	1548	2371	34952927
Disinhibition	475.10	225.69	88	1545	3138	34952160
Obsessive-compulsive disorder	450.85	225.69	92	1541	5472	34949826
Euphoric mood	431.90	225.69	89	1544	5552	34949746
Increased appetite	401.88	225.69	88	1545	7341	34947957
Akathisia	394.20	225.69	88	1545	8021	34947277
Suicide attempt	280.89	225.69	94	1539	39022	34916276

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Antipsychotic drug level below therapeutic	157.59	62.82	25	1072	1213	79742078
Therapeutic product effect variable	145.50	62.82	25	1072	1984	79741307
Disinhibition	139.08	62.82	25	1072	2573	79740718
Obsessive-compulsive disorder	124.28	62.82	26	1071	5901	79737390
Euphoric mood	122.95	62.82	27	1070	7699	79735592
Suicide attempt	107.73	62.82	41	1056	82891	79660400
Dyslipidaemia	101.73	62.82	25	1072	11608	79731683
Increased appetite	101.00	62.82	25	1072	11953	79731338
Akathisia	98.48	62.82	25	1072	13234	79730057
Obesity	74.42	62.82	25	1072	35100	79708191
Irritability	70.54	62.82	25	1072	41119	79702172

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N05AB06	NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Phenothiazines with piperazine structure
FDA CS	M0016525	Phenothiazines
MeSH PA	D000932	Antiemetics
MeSH PA	D014150	Antipsychotic Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D015259	Dopamine Agents
MeSH PA	D018492	Dopamine Antagonists
MeSH PA	D005765	Gastrointestinal Agents
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D011619	Psychotropic Drugs
MeSH PA	D014149	Tranquilizing Agents
FDA EPC	N0000175746	Phenothiazine
CHEBI has role	CHEBI:37930	phenothiazine antipsychotic drugs
CHEBI has role	CHEBI:48561	dopaminergic antagonists
CHEBI has role	CHEBI:50919	antiemetico
CHEBI has role	CHEBI:77402	EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitors
CHEBI has role	CHEBI:86385	Delta(7)-cholestenol Delta(7)-Delta(8)-isomerase inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Anxiety	indication	48694002
Schizophrenia	indication	58214004	DOID:5419
Neuroleptic malignant syndrome	contraindication	15244003	DOID:14464
Senile dementia	contraindication	15662003
Cirrhosis of liver	contraindication	19943007	DOID:5082
Glaucoma	contraindication	23986001	DOID:1686
Orthostatic hypotension	contraindication	28651003
Retinal disorder	contraindication	29555009	DOID:5679
Alcoholic liver damage	contraindication	41309000
Low blood pressure	contraindication	45007003
Chronic hepatitis	contraindication	76783007	DOID:2237
Epilepsy	contraindication	84757009	DOID:1826
Tardive dyskinesia	contraindication	102449007
Diminished sweating	contraindication	111980002
Angina pectoris	contraindication	194828000
Disease of liver	contraindication	235856003	DOID:409
Benign prostatic hyperplasia	contraindication	266569009
Retention of urine	contraindication	267064002
Anemia	contraindication	271737000	DOID:2355
Thrombocytopenic disorder	contraindication	302215000	DOID:1588
Neutropenic disorder	contraindication	303011007	DOID:1227
Visual impairment	contraindication	397540003
Breastfeeding (mother)	contraindication	413712001
Carcinoma of female breast	contraindication	447782002

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.74	Basic
pKa2	4.74	Basic
pKa3	2.72	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN	ANTAGONIST	Ki	8.84		PDSP	CHEMBL
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN		Ki	6.19		PDSP
Sigma non-opioid intracellular receptor 1	Membrane receptor	Q99720	SGMR1_HUMAN		Ki	7.82		CHEMBL
Potassium voltage-gated channel subfamily H member 2	Ion channel	Q12809	KCNH2_HUMAN		Ki	5.29		DRUG MATRIX
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	Enzyme	Q15125	EBP_HUMAN		Ki	8.10		CHEMBL
Multidrug resistance protein 1	Transporter	P08183	MDR1_HUMAN		Ki	5.19		CHEMBL
5-hydroxytryptamine receptor 1A	GPCR	P08908	5HT1A_HUMAN		Ki	6.02		PDSP
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN	ANTAGONIST	Ki	7.90		IUPHAR
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN	ANTAGONIST	Ki	6.40		IUPHAR
5-hydroxytryptamine receptor 6	GPCR	P50406	5HT6R_HUMAN		Ki	6.85		PDSP
5-hydroxytryptamine receptor 7	GPCR	P34969	5HT7R_HUMAN		Ki	6.54		PDSP
Alpha-1A adrenergic receptor	GPCR	P35348	ADA1A_HUMAN		Ki	7.62		PDSP
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN		Ki	6.79		PDSP
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN	ANTAGONIST	Ki	9.25		PDSP
Histamine H1 receptor	GPCR	P35367	HRH1_HUMAN	ANTAGONIST	Ki	7.20		IUPHAR
Muscarinic acetylcholine receptor M3	GPCR	P20309	ACM3_HUMAN		Ki	6		PDSP
Alpha-2C adrenergic receptor	GPCR	P18825	ADA2C_HUMAN		Ki	6.41		PDSP
D(4) dopamine receptor	GPCR	P21917	DRD4_HUMAN	ANTAGONIST	Ki	7.38		PDSP
Calmodulin	Cytosolic other	P0DP23 P0DP24 P0DP25	CALM1_HUMAN CALM2_HUMAN CALM3_HUMAN		Kd	6		CHEMBL
DNA-dependent protein kinase catalytic subunit	Kinase	P78527	PRKDC_HUMAN		IC50	4		CHEMBL
Emopamil-binding protein-like	Enzyme	Q9BY08	EBPL_HUMAN		Ki	8.41		CHEMBL
Sodium channel alpha subunits; brain (Types I, II, III)	Ion channel	P35498 Q99250 Q9NY46	SCN1A_HUMAN SCN2A_HUMAN SCN3A_HUMAN		IC50	5.30		CHEMBL
Trypanothione reductase	Enzyme		TYTR_TRYCR		Ki	4.64		CHEMBL
D(2) dopamine receptor	GPCR		DRD2_RAT		Kd	9.27		CHEMBL
5-hydroxytryptamine receptor 1A	GPCR		5HT1A_RAT		Ki	6.39		CHEMBL
NS3	Enzyme		A3EZI9_9HEPC		IC50	6.15		CHEMBL
Lysozyme C-1	Enzyme		LYSC1_RAT		IC50	5.05		CHEMBL
C-8 sterol isomerase	Enzyme		ERG2_YEAST		Ki	6.30		CHEMBL
Pleiotropic ABC efflux transporter of multiple drugs	Transporter		PDR5_YEAST		IC50	5.85		CHEMBL
Adrenergic receptor alpha-1	GPCR		ADA1B_RAT ADA1D_RAT ADA1A_RAT		Ki	7.53		CHEMBL
Serotonin 2 (5-HT2) receptor	GPCR		5HT2C_RAT 5HT2A_RAT 5HT2B_RAT		Kd	8.98		CHEMBL
Calmodulin	Cytosolic other		CALM_BOVIN		Kd	5.47		CHEMBL
Genome polyprotein	Unclassified		A3EZJ3_9HEPC		IC50	6.16		CHEMBL
Beta-glucuronidase	Enzyme		BGLR_RAT		IC50	5.11		CHEMBL
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	Enzyme		AT2A1_RABIT		IC50	4.35		CHEMBL

External reference:

ID	Source
4019957	VUID
N0000148042	NUI
D00799	KEGG_DRUG
440-17-5	SECONDARY_CAS_RN
4018843	VANDF
4019957	VANDF
C0040979	UMLSCUI
CHEBI:45951	CHEBI
CHEMBL422	ChEMBL_ID
CHEMBL1257040	ChEMBL_ID
CHEMBL1710	ChEMBL_ID
D014268	MESH_DESCRIPTOR_UI
DB00831	DRUGBANK_ID
5566	PUBCHEM_CID
214	IUPHAR_LIGAND_ID
718	INN_ID
214IZI85K3	UNII
10800	RXNORM
2926	MMSL
5625	MMSL
d00890	MMSL
001481	NDDF
004590	NDDF
373524005	SNOMEDCT_US
50754002	SNOMEDCT_US
71699007	SNOMEDCT_US
TFP	PDB_CHEM_ID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Trifluoperazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0378-2401	TABLET, FILM COATED	1 mg	ORAL	ANDA	16 sections
Trifluoperazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0378-2402	TABLET, FILM COATED	2 mg	ORAL	ANDA	16 sections
Trifluoperazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0378-2405	TABLET, FILM COATED	5 mg	ORAL	ANDA	16 sections
Trifluoperazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0378-2410	TABLET, FILM COATED	10 mg	ORAL	ANDA	16 sections
Trifluoperazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0781-8028	TABLET, FILM COATED	1 mg	ORAL	ANDA	15 sections
Trifluoperazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0781-8028	TABLET, FILM COATED	1 mg	ORAL	ANDA	15 sections
Trifluoperazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0781-8032	TABLET, FILM COATED	2 mg	ORAL	ANDA	15 sections
Trifluoperazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0781-8032	TABLET, FILM COATED	2 mg	ORAL	ANDA	15 sections
Trifluoperazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0781-8034	TABLET, FILM COATED	5 mg	ORAL	ANDA	15 sections
Trifluoperazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0781-8034	TABLET, FILM COATED	5 mg	ORAL	ANDA	15 sections
Trifluoperazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0781-8036	TABLET, FILM COATED	10 mg	ORAL	ANDA	15 sections
Trifluoperazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0781-8036	TABLET, FILM COATED	10 mg	ORAL	ANDA	15 sections
Trifluoperazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0832-0494	TABLET, FILM COATED	1 mg	ORAL	ANDA	15 sections
Trifluoperazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0832-0495	TABLET, FILM COATED	2 mg	ORAL	ANDA	15 sections
Trifluoperazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0832-0496	TABLET, FILM COATED	5 mg	ORAL	ANDA	15 sections
Trifluoperazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0832-0497	TABLET, FILM COATED	10 mg	ORAL	ANDA	15 sections
TRIFLUOPERAZINE	HUMAN PRESCRIPTION DRUG LABEL	1	16590-305	TABLET, FILM COATED	2 mg	ORAL	ANDA	11 sections
Trifluoperazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	51079-572	TABLET, FILM COATED	1 mg	ORAL	ANDA	16 sections
Trifluoperazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	51079-573	TABLET, FILM COATED	2 mg	ORAL	ANDA	16 sections
Trifluoperazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	51079-574	TABLET, FILM COATED	5 mg	ORAL	ANDA	16 sections
Trifluoperazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	51079-575	TABLET, FILM COATED	10 mg	ORAL	ANDA	16 sections
Trifluoperazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	53808-0629	TABLET, FILM COATED	2 mg	ORAL	ANDA	15 sections
Trifluoperazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	53808-0819	TABLET, FILM COATED	10 mg	ORAL	ANDA	15 sections
Trifluoperazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	70518-1960	TABLET, FILM COATED	10 mg	ORAL	ANDA	16 sections
Trifluoperazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	70518-2095	TABLET, FILM COATED	2 mg	ORAL	ANDA	16 sections
Trifluoperazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	70518-2095	TABLET, FILM COATED	2 mg	ORAL	ANDA	16 sections
Trifluoperazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	70518-2095	TABLET, FILM COATED	2 mg	ORAL	ANDA	16 sections
Trifluoperazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	70518-2106	TABLET, FILM COATED	5 mg	ORAL	ANDA	16 sections
Trifluoperazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	70518-2106	TABLET, FILM COATED	5 mg	ORAL	ANDA	16 sections