Stem definition | Drug id | CAS RN |
---|---|---|
2100 | 84-97-9 |
Dose | Unit | Route |
---|---|---|
0.10 | g | O |
0.10 | g | P |
None
None
None
None
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug interaction | 65.62 | 47.85 | 53 | 1195 | 415130 | 79328010 |
None
Source | Code | Description |
---|---|---|
ATC | N05AB10 | NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Phenothiazines with piperazine structure |
MeSH PA | D014150 | Antipsychotic Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D015259 | Dopamine Agents |
MeSH PA | D018492 | Dopamine Antagonists |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D014149 | Tranquilizing Agents |
CHEBI has role | CHEBI:37930 | phenothiazine antipsychotic drugs |
CHEBI has role | CHEBI:48561 | dopaminergic antagonists |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Ascariasis | indication | 2435008 | DOID:456 |
Nausea and vomiting | indication | 16932000 | |
Anxiety | indication | 48694002 | |
Schizophrenia | indication | 58214004 | DOID:5419 |
Chemotherapy-induced nausea and vomiting | indication | 236084000 | |
Enterobiasis | indication | 266162007 | |
Vomiting | indication | 422400008 | |
Nausea | indication | 422587007 | |
Nonpsychotic Anxiety | indication | ||
Prolonged-Severe Nausea and Vomiting | indication | ||
Brain damage | contraindication | 2470005 | |
Tachyarrhythmia | contraindication | 6285003 | |
Urinary tract obstruction | contraindication | 7163005 | DOID:5200 |
Alcoholism | contraindication | 7200002 | |
Organophosphate poisoning | contraindication | 8260003 | |
Weight gain finding | contraindication | 8943002 | |
Severe chronic ulcerative colitis | contraindication | 14311001 | |
Neuroleptic malignant syndrome | contraindication | 15244003 | DOID:14464 |
Senile dementia | contraindication | 15662003 | |
Chronic disease of respiratory system | contraindication | 17097001 | |
Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Glaucoma | contraindication | 23986001 | DOID:1686 |
Toxic megacolon | contraindication | 28536002 | DOID:1770 |
Orthostatic hypotension | contraindication | 28651003 | |
Atony of colon | contraindication | 29479008 | |
Retinal disorder | contraindication | 29555009 | DOID:5679 |
Torsades de pointes | contraindication | 31722008 | |
Parkinsonism | contraindication | 32798002 | |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Complete trisomy 21 syndrome | contraindication | 41040004 | DOID:14250 |
Alcoholic liver damage | contraindication | 41309000 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Low blood pressure | contraindication | 45007003 | |
Achalasia of esophagus | contraindication | 45564002 | DOID:9164 |
Chronic heart failure | contraindication | 48447003 | |
Bradycardia | contraindication | 48867003 | |
Paralytic ileus | contraindication | 55525008 | DOID:8442 |
Peptic reflux disease | contraindication | 57643001 | |
Ulcerative colitis | contraindication | 64766004 | DOID:8577 |
Drug AND/OR toxin-induced diarrhea | contraindication | 65979008 | |
Extrapyramidal disease | contraindication | 76349003 | |
Chronic hepatitis | contraindication | 76783007 | DOID:2237 |
Spastic paralysis | contraindication | 78403003 | |
Disturbance of salivary secretion | contraindication | 78948009 | |
Hyperglycemia | contraindication | 80394007 | DOID:4195 |
Hiatal hernia | contraindication | 84089009 | DOID:12642 |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Leukopenia | contraindication | 84828003 | DOID:615 |
Stupor | contraindication | 89458003 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Tardive dyskinesia | contraindication | 102449007 | |
Prolonged QT interval | contraindication | 111975006 | |
Diminished sweating | contraindication | 111980002 | |
Gastrointestinal obstruction | contraindication | 126765001 | |
Acute disease of cardiovascular system | contraindication | 128487001 | |
Autonomic dysreflexia | contraindication | 129618003 | |
Bleeding | contraindication | 131148009 | |
Angina pectoris | contraindication | 194828000 | |
Myocardial dysfunction | contraindication | 233928007 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Bladder outflow obstruction | contraindication | 236645006 | |
Metabolic syndrome X | contraindication | 237602007 | DOID:14221 |
Hyperprolactinemia | contraindication | 237662005 | DOID:12700 |
Pyloric obstruction | contraindication | 244815007 | |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Retention of urine | contraindication | 267064002 | |
Anemia | contraindication | 271737000 | DOID:2355 |
Drowsy | contraindication | 271782001 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Coma | contraindication | 371632003 | |
At risk for aspiration | contraindication | 371736008 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Visual impairment | contraindication | 397540003 | |
Gastric ulcer | contraindication | 397825006 | DOID:10808 |
Breastfeeding (mother) | contraindication | 413712001 | |
Chronic lung disease | contraindication | 413839001 | |
Disorder of coronary artery | contraindication | 414024009 | |
Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
Obesity | contraindication | 414916001 | DOID:9970 |
Congenital long QT syndrome | contraindication | 442917000 | |
Carcinoma of female breast | contraindication | 447782002 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.74 | Basic |
pKa2 | 4.74 | Basic |
pKa3 | 3.55 | Basic |
None
None
None
ID | Source |
---|---|
N0000167278 | NUI |
C0030969 | UMLSCUI |
CHEBI:59118 | CHEBI |
CHEMBL1697766 | ChEMBL_ID |
DB12710 | DRUGBANK_ID |
D010464 | MESH_DESCRIPTOR_UI |
4744 | PUBCHEM_CID |
8915147A2B | UNII |
8042 | RXNORM |
006779 | NDDF |
25002001 | SNOMEDCT_US |
None