cyanocobalamin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4196 68-19-9

Description:

MoleculeDescription

Synonyms:

  • cyanocobalamin
  • vitamin B12
  • cobamin
  • cyanocobalamine
  • Molecular weight: 1355.39
  • Formula: C63H88CoN14O14P
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 512.50
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
70 mcg N
1 mg O
20 mcg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 12.50 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.42 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Sept. 15, 1949 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1139.01 10.03 104 950150 144954 89533239
Pemphigus 1134.69 10.03 6565 943689 320299 89357894
Systemic lupus erythematosus 1115.50 10.03 7047 943207 354849 89323344
Toxicity to various agents 1084.66 10.03 857 949397 286989 89391204
Glossodynia 951.31 10.03 6201 944053 315578 89362615
Arthropathy 785.03 10.03 6538 943716 359704 89318489
Hand deformity 770.90 10.03 5535 944719 290827 89387366
Alopecia 762.08 10.03 8237 942017 486834 89191359
Abdominal discomfort 755.74 10.03 7987 942267 469341 89208852
Drug interaction 633.95 10.03 1209 949045 275244 89402949
Wound 607.93 10.03 5331 944923 297649 89380544
Intentional overdose 585.09 10.03 133 950121 93701 89584492
Synovitis 530.20 10.03 5537 944717 324215 89353978
Drug abuse 510.87 10.03 118 950136 82229 89595964
Swelling 504.86 10.03 6656 943598 412402 89265791
Anti-cyclic citrullinated peptide antibody positive 493.84 10.03 4198 946056 232235 89445958
Maternal exposure during pregnancy 490.08 10.03 5851 944403 354212 89323981
Pericarditis 475.88 10.03 4623 945631 265528 89412665
Discomfort 475.63 10.03 4679 945575 269656 89408537
Death 440.48 10.03 2890 947364 453661 89224532
Febrile neutropenia 418.44 10.03 632 949622 157717 89520476
Joint swelling 406.97 10.03 7474 942780 495826 89182367
Contraindicated product administered 402.53 10.03 5126 945128 315013 89363180
Suicide attempt 401.57 10.03 144 950110 75255 89602938
Rheumatoid arthritis 387.93 10.03 5640 944614 356974 89321219
Pain 385.48 10.03 13392 936862 982949 88695244
Duodenal ulcer perforation 381.32 10.03 3770 946484 217518 89460675
Infusion related reaction 371.29 10.03 6286 943968 410494 89267699
Overdose 370.73 10.03 679 949575 157030 89521163
Helicobacter infection 358.07 10.03 3796 946458 223054 89455139
Electrocardiogram QT prolonged 317.82 10.03 182 950072 72274 89605919
Malignant neoplasm progression 311.88 10.03 397 949857 106473 89571720
Rheumatoid factor positive 309.68 10.03 2953 947301 168697 89509496
Disease progression 307.94 10.03 746 949508 155869 89522324
Depressed level of consciousness 303.62 10.03 194 950060 72590 89605603
Cardiac arrest 297.81 10.03 398 949856 104537 89573656
Arthralgia 296.10 10.03 10447 939807 768075 88910118
Psoriatic arthropathy 283.35 10.03 3648 946606 224687 89453506
Neutropenia 279.24 10.03 1309 948945 223595 89454598
Acute kidney injury 271.22 10.03 2105 948149 318282 89359911
Musculoskeletal stiffness 232.39 10.03 4384 945870 292148 89386045
Hepatic enzyme increased 226.93 10.03 5163 945091 355573 89322620
Nasopharyngitis 226.24 10.03 5728 944526 401376 89276817
Fatigue 217.82 10.03 14451 935803 1139572 88538621
Hyponatraemia 215.14 10.03 700 949554 132838 89545355
Product use issue 215.05 10.03 4746 945508 325173 89353020
Myelosuppression 211.27 10.03 152 950102 53439 89624754
Drug reaction with eosinophilia and systemic symptoms 210.69 10.03 92 950162 42666 89635527
Hypotension 210.28 10.03 2288 947966 323109 89355084
Lactic acidosis 207.08 10.03 137 950117 50326 89627867
Therapeutic product effect decreased 207.02 10.03 4073 946181 273498 89404695
Sedation 207.01 10.03 124 950130 48047 89630146
Cardiac failure 186.95 10.03 559 949695 108937 89569256
Serotonin syndrome 185.92 10.03 82 950172 37805 89640388
Impaired healing 185.66 10.03 3469 946785 230730 89447463
Bradycardia 182.23 10.03 378 949876 83469 89594724
Drug ineffective for unapproved indication 175.96 10.03 266 949988 66378 89611815
Thrombocytopenia 173.88 10.03 1377 948877 207348 89470845
Sopor 163.83 10.03 30 950224 24614 89653579
Hyperhidrosis 162.88 10.03 804 949450 135501 89542692
Fibromyalgia 159.23 10.03 3043 947211 203226 89474967
Constipation 158.57 10.03 2030 948224 278365 89399828
Rheumatic fever 158.43 10.03 2369 947885 150752 89527441
Cardio-respiratory arrest 156.33 10.03 263 949991 62877 89615316
Multiple organ dysfunction syndrome 156.29 10.03 299 949955 68037 89610156
Angioedema 156.26 10.03 275 949979 64601 89613592
Drug resistance 155.69 10.03 62 950192 30387 89647806
Coma 154.85 10.03 331 949923 72301 89605892
Off label use 154.34 10.03 9731 940523 1092521 88585672
Agitation 153.10 10.03 294 949960 66804 89611389
Hepatic function abnormal 151.20 10.03 157 950097 46131 89632062
Respiratory failure 150.58 10.03 683 949571 117735 89560458
Folliculitis 150.38 10.03 2993 947261 201360 89476833
Blister 150.16 10.03 3617 946637 251381 89426812
Rhabdomyolysis 145.82 10.03 194 950060 51062 89627131
Knee arthroplasty 140.59 10.03 1412 948842 81770 89596423
Sleep disorder due to general medical condition, insomnia type 138.98 10.03 2006 948248 126688 89551505
Renal failure 138.63 10.03 805 949449 130202 89547991
Macular degeneration 137.89 10.03 117 950137 37853 89640340
Hip arthroplasty 137.79 10.03 1312 948942 74896 89603297
Somnolence 135.03 10.03 1470 948784 207614 89470579
Tachycardia 133.24 10.03 1036 949218 156637 89521556
Hypoglycaemia 132.32 10.03 339 949915 69509 89608684
Hepatic failure 131.76 10.03 133 950121 39595 89638598
Muscle injury 130.85 10.03 2590 947664 174064 89504129
Swollen joint count increased 130.83 10.03 1760 948494 109446 89568747
Sedation complication 130.68 10.03 13 950241 16931 89661262
Irritable bowel syndrome 130.23 10.03 2969 947285 204479 89473714
Anaemia 129.25 10.03 2767 947487 350035 89328158
Cytokine release syndrome 127.40 10.03 67 950187 27906 89650287
Intentional self-injury 126.76 10.03 75 950179 29259 89648934
Lower respiratory tract infection 126.10 10.03 3482 946772 247177 89431016
Metabolic acidosis 125.24 10.03 246 950008 55430 89622763
Contusion 123.65 10.03 3480 946774 247736 89430457
Nausea 121.54 10.03 10010 940244 1100306 88577887
Respiratory arrest 119.31 10.03 104 950150 33207 89644986
Renal impairment 117.94 10.03 636 949618 104785 89573408
Red blood cell sedimentation rate abnormal 117.08 10.03 534 949720 23670 89654523
C-reactive protein abnormal 115.70 10.03 1929 948325 125500 89552693
Anaphylactic reaction 115.38 10.03 498 949756 87026 89591167
Seizure 114.44 10.03 1035 949219 151594 89526599
Device expulsion 114.03 10.03 157 950097 40729 89637464
Type 2 diabetes mellitus 113.95 10.03 2864 947390 200380 89477813
Hepatocellular injury 113.01 10.03 83 950171 28875 89649318
Sinusitis 112.79 10.03 4533 945721 338555 89339638
Sickle cell anaemia with crisis 110.90 10.03 240 950014 7057 89671136
Temperature regulation disorder 110.34 10.03 12 950242 14567 89663626
Drug intolerance 109.93 10.03 5742 944512 441849 89236344
Intentional product misuse 109.07 10.03 525 949729 89079 89589114
Blood cholesterol increased 108.98 10.03 2905 947349 205107 89473086
Hyperglycaemia 108.88 10.03 232 950022 50738 89627455
No adverse event 106.95 10.03 360 949894 67622 89610571
Hypersensitivity 105.30 10.03 5801 944453 448876 89229317
Anaphylactic shock 103.54 10.03 107 950147 31510 89646683
Creatinine renal clearance decreased 102.49 10.03 35 950219 18864 89659329
Intentional product use issue 102.41 10.03 2989 947265 213903 89464290
Leukopenia 102.23 10.03 627 949627 100083 89578110
Shock 101.68 10.03 91 950163 28687 89649506
Cytomegalovirus infection 101.56 10.03 78 950176 26524 89651669
Arthritis 101.39 10.03 2383 947871 164932 89513261
Metastases to bone 99.66 10.03 73 950181 25432 89652761
Altered state of consciousness 98.49 10.03 111 950143 31421 89646772
Osteoarthritis 98.41 10.03 2719 947535 193011 89485182
Cognitive disorder 98.31 10.03 384 949870 69023 89609170
Orthostatic hypotension 98.30 10.03 180 950074 41647 89636546
Neoplasm progression 97.12 10.03 200 950054 44286 89633907
Exposure during pregnancy 96.82 10.03 3226 947028 235184 89443009
Hyperkalaemia 95.52 10.03 354 949900 64610 89613583
Peripheral swelling 95.50 10.03 5270 944984 407836 89270357
Ill-defined disorder 94.81 10.03 2575 947679 182316 89495877
Cholestasis 93.79 10.03 147 950107 36152 89642041
Syncope 92.45 10.03 916 949338 131747 89546446
Sepsis 90.39 10.03 1333 948921 178481 89499712
Mydriasis 90.18 10.03 23 950231 14989 89663204
Hepatotoxicity 89.54 10.03 219 950035 45623 89632570
Neutrophil count decreased 89.48 10.03 415 949839 71117 89607076
Stomatitis 89.44 10.03 3626 946628 271072 89407121
Ventricular tachycardia 88.66 10.03 77 950177 24631 89653562
Respiratory depression 87.72 10.03 27 950227 15548 89662645
Product use in unapproved indication 87.02 10.03 2773 947481 333463 89344730
Ejection fraction decreased 86.93 10.03 88 950166 26165 89652028
Suspected suicide 86.80 10.03 3 950251 9565 89668628
Hypoxia 86.49 10.03 427 949827 71972 89606221
Treatment failure 86.48 10.03 3956 946298 299972 89378221
Acute hepatic failure 86.32 10.03 66 950188 22495 89655698
Palmar-plantar erythrodysaesthesia syndrome 84.99 10.03 101 950153 27922 89650271
Vomiting 83.40 10.03 7124 943130 781169 88897024
Weight increased 81.92 10.03 5254 945000 412673 89265520
Food allergy 81.44 10.03 88 950166 25390 89652803
Liver injury 80.88 10.03 2352 947902 168215 89509978
Rash erythematous 80.67 10.03 379 949875 64725 89613468
Schizophrenia 80.22 10.03 28 950226 14886 89663307
Posterior reversible encephalopathy syndrome 79.70 10.03 70 950184 22269 89655924
Poisoning 79.43 10.03 30 950224 15187 89663006
Neurotoxicity 79.36 10.03 65 950189 21402 89656791
Myalgia 79.34 10.03 1324 948930 173801 89504392
Encephalopathy 79.33 10.03 237 950017 46207 89631986
Drug level increased 79.04 10.03 105 950149 27657 89650536
Drug dependence 78.43 10.03 116 950138 29211 89648982
Blood glucose increased 77.58 10.03 632 949622 94614 89583579
Torsade de pointes 77.48 10.03 31 950223 15151 89663042
Drug hypersensitivity 77.35 10.03 4022 946232 459587 89218606
Metastases to liver 76.99 10.03 114 950140 28693 89649500
Gamma-glutamyltransferase increased 75.96 10.03 179 950075 37773 89640420
Drug withdrawal syndrome 75.47 10.03 115 950139 28608 89649585
Suicidal ideation 74.33 10.03 461 949793 73394 89604799
Thrombotic microangiopathy 74.26 10.03 36 950218 15707 89662486
Therapy partial responder 74.01 10.03 73 950181 21970 89656223
Osteonecrosis of jaw 73.12 10.03 191 950063 38912 89639281
Inflammation 72.58 10.03 2417 947837 176175 89502018
Wrong technique in product usage process 72.41 10.03 446 949808 71125 89607068
Pregnancy 72.14 10.03 980 949274 61067 89617126
Erythema 71.87 10.03 1841 948413 227405 89450788
Blood creatine phosphokinase increased 70.90 10.03 157 950097 33866 89644327
Accidental exposure to product 70.36 10.03 219 950035 42147 89636046
Blood pressure fluctuation 70.31 10.03 850 949404 51563 89626630
Ascites 70.28 10.03 260 949994 47480 89630713
Metastases to central nervous system 70.13 10.03 49 950205 17493 89660700
Blood calcium decreased 69.94 10.03 131 950123 30051 89648142
Unresponsive to stimuli 69.17 10.03 189 950065 37932 89640261
Blood bilirubin increased 68.51 10.03 230 950024 43240 89634953
Dyspnoea 68.14 10.03 8143 942111 872812 88805381
Blood pressure systolic abnormal 67.84 10.03 392 949862 19086 89659107
Colitis 67.61 10.03 442 949812 69500 89608693
Proteinuria 67.43 10.03 87 950167 23204 89654989
Psoriasis 66.67 10.03 2025 948229 145729 89532464
Parkinsonism 66.59 10.03 32 950222 14033 89664160
Vaginal flatulence 65.82 10.03 25 950229 12613 89665580
Blood pressure diastolic abnormal 65.30 10.03 394 949860 19487 89658706
Disability assessment scale score increased 65.21 10.03 134 950120 3797 89674396
Carpal tunnel syndrome 64.40 10.03 451 949803 23477 89654716
Hypothermia 64.28 10.03 42 950212 15533 89662660
Myocardial infarction 64.07 10.03 756 949498 105216 89572977
Status epilepticus 63.95 10.03 62 950192 18812 89659381
Disseminated intravascular coagulation 62.82 10.03 80 950174 21458 89656735
Cardiac failure congestive 62.43 10.03 697 949557 97997 89580196
Hypokalaemia 62.12 10.03 983 949271 130133 89548060
Exposure to toxic agent 61.74 10.03 6 950248 7961 89670232
Tremor 61.17 10.03 1184 949070 151989 89526204
Loss of personal independence in daily activities 61.04 10.03 1864 948390 134241 89543952
Transplant rejection 60.44 10.03 29 950225 12729 89665464
Pulmonary fibrosis 60.24 10.03 1515 948739 105988 89572205
Diabetic ketoacidosis 60.10 10.03 102 950152 24305 89653888
Miosis 60.00 10.03 13 950241 9471 89668722
Mucosal inflammation 59.92 10.03 356 949898 57269 89620924
Psychotic disorder 59.59 10.03 151 950103 31079 89647114
Rash 59.52 10.03 9359 940895 786741 88891452
Blood alkaline phosphatase increased 59.50 10.03 280 949974 47799 89630394
Polyneuropathy 59.42 10.03 69 950185 19272 89658921
Nasal polyps 59.26 10.03 20 950234 10860 89667333
Chronic sinusitis 59.04 10.03 99 950155 23703 89654490
Grip strength decreased 58.67 10.03 1327 948927 91249 89586944
Hepatic cytolysis 58.59 10.03 150 950104 30766 89647427
Injury 58.55 10.03 2580 947674 194769 89483424
Pancreatitis acute 58.44 10.03 159 950095 31956 89646237
Akathisia 58.24 10.03 22 950232 11137 89667056
Haemophagocytic lymphohistiocytosis 58.16 10.03 46 950208 15413 89662780
Pleural effusion 57.38 10.03 827 949427 111164 89567029
Myoclonus 57.16 10.03 70 950184 19098 89659095
Extrapyramidal disorder 57.06 10.03 52 950202 16251 89661942
Cardiogenic shock 56.87 10.03 106 950148 24362 89653831
Stevens-Johnson syndrome 56.85 10.03 141 950113 29235 89648958
Facet joint syndrome 56.75 10.03 1392 948862 96997 89581196
Respiratory distress 56.75 10.03 213 950041 38733 89639460
Hypomania 56.68 10.03 12 950242 8885 89669308
Proctitis 56.66 10.03 46 950208 15213 89662980
Device difficult to use 56.61 10.03 60 950194 17465 89660728
Blood pressure systolic increased 56.58 10.03 893 949361 57452 89620741
Acute generalised exanthematous pustulosis 56.49 10.03 37 950217 13666 89664527
Joint effusion 56.31 10.03 377 949877 19333 89658860
Condition aggravated 55.98 10.03 7096 943158 588449 89089744
Joint range of motion decreased 55.93 10.03 1839 948415 133804 89544389
Live birth 55.60 10.03 1151 949103 77956 89600237
Toxic skin eruption 55.59 10.03 50 950204 15724 89662469
Cerebral haemorrhage 55.54 10.03 181 950073 34341 89643852
Bronchopulmonary aspergillosis 55.40 10.03 25 950229 11373 89666820
Ejection fraction 55.18 10.03 107 950147 2904 89675289
Basal cell carcinoma 55.07 10.03 564 949690 32825 89645368
Sensitisation 54.19 10.03 129 950125 4046 89674147
Coagulopathy 54.04 10.03 101 950153 23188 89655005
Haematotoxicity 52.83 10.03 33 950221 12502 89665691
Disorientation 52.79 10.03 260 949994 43854 89634339
Brain oedema 52.36 10.03 63 950191 17322 89660871
Sinus tachycardia 52.01 10.03 141 950113 28372 89649821
Lip dry 52.00 10.03 1407 948847 99548 89578645
Diarrhoea 51.78 10.03 8860 941394 930330 88747863
Female genital tract fistula 51.46 10.03 67 950187 17801 89660392
Pulmonary embolism 51.38 10.03 1014 949240 129806 89548387
Disturbance in attention 51.14 10.03 287 949967 46822 89631371
Blood creatinine increased 51.14 10.03 751 949503 100635 89577558
Neuroleptic malignant syndrome 50.67 10.03 50 950204 15046 89663147
Paraesthesia oral 50.24 10.03 167 950087 31492 89646701
Unintentional medical device removal 50.23 10.03 7 950247 7023 89671170
Procedural pain 50.22 10.03 180 950074 33180 89645013
Ventricular fibrillation 50.11 10.03 44 950210 14000 89664193
Graft versus host disease 49.85 10.03 12 950242 8132 89670061
Aspergillus infection 49.17 10.03 26 950228 10797 89667396
Dystonia 48.51 10.03 63 950191 16756 89661437
Inappropriate antidiuretic hormone secretion 48.50 10.03 81 950173 19424 89658769
Aspartate aminotransferase increased 48.33 10.03 773 949481 102164 89576029
Metastases to lung 48.11 10.03 58 950196 15933 89662260
Bronchospasm 47.88 10.03 90 950164 20619 89657574
Drug use disorder 47.83 10.03 14 950240 8329 89669864
Mobility decreased 47.76 10.03 3145 947109 247589 89430604
Restlessness 47.22 10.03 203 950051 35517 89642676
Pain in extremity 46.88 10.03 5403 944851 445126 89233067
Alanine aminotransferase increased 46.85 10.03 916 949338 117422 89560771
Disease recurrence 46.76 10.03 219 950035 37434 89640759
Abortion spontaneous 46.75 10.03 812 949442 53244 89624949
Platelet count decreased 46.71 10.03 1086 949168 135883 89542310
Asphyxia 46.46 10.03 9 950245 7094 89671099
Juvenile idiopathic arthritis 46.45 10.03 118 950136 3859 89674334
Tachypnoea 46.34 10.03 96 950158 21213 89656980
Circulatory collapse 46.30 10.03 122 950132 24782 89653411
Swollen tongue 46.16 10.03 287 949967 45669 89632524
Mania 46.02 10.03 48 950206 14076 89664117
Joint destruction 46.01 10.03 267 949987 13020 89665173
Hypomagnesaemia 45.98 10.03 204 950050 35384 89642809
Face oedema 45.85 10.03 111 950143 23207 89654986
Interstitial lung disease 45.44 10.03 547 949707 75858 89602335
Arrhythmia 45.36 10.03 259 949995 42073 89636120
Withdrawal syndrome 45.26 10.03 106 950148 22418 89655775
International normalised ratio increased 45.23 10.03 300 949954 47016 89631177
Deep vein thrombosis postoperative 45.18 10.03 1016 949238 69793 89608400
Radiculopathy 44.95 10.03 78 950176 18427 89659766
Acute myeloid leukaemia 44.88 10.03 93 950161 20547 89657646
Polycystic ovaries 44.87 10.03 146 950108 5508 89672685
Loss of consciousness 44.79 10.03 1123 949131 139115 89539078
Red blood cell sedimentation rate increased 44.51 10.03 1158 949096 81437 89596756
Mental status changes 44.38 10.03 280 949974 44399 89633794
Aggression 44.18 10.03 138 950116 26530 89651663
Jaundice 44.09 10.03 183 950071 32334 89645859
Hallucination 44.05 10.03 460 949794 65499 89612694
Stress cardiomyopathy 43.95 10.03 45 950209 13310 89664883
Heart rate decreased 43.88 10.03 797 949457 52708 89625485
Pulmonary oedema 42.67 10.03 430 949824 61650 89616543
Pseudomonas infection 42.55 10.03 56 950198 14809 89663384
Chest discomfort 42.32 10.03 1115 949139 137250 89540943
Pyrexia 42.26 10.03 6177 944077 654308 89023885
Vaginal discharge 42.07 10.03 88 950166 19376 89658817
Agranulocytosis 42.05 10.03 206 950048 34796 89643397
Febrile bone marrow aplasia 41.93 10.03 25 950229 9713 89668480
Obstructive airways disorder 41.36 10.03 136 950118 25733 89652460
Multiple-drug resistance 41.14 10.03 15 950239 7761 89670432
General physical health deterioration 41.10 10.03 4289 945965 350826 89327367
Foot deformity 40.96 10.03 865 949389 58786 89619407
Haemoptysis 40.67 10.03 195 950059 33125 89645068
Pain in jaw 40.64 10.03 315 949939 47670 89630523
Joint laxity 40.58 10.03 87 950167 2541 89675652
Polyarthritis 40.45 10.03 330 949924 18020 89660173
Acute respiratory distress syndrome 40.43 10.03 159 950095 28527 89649666
Gastrointestinal disorder 40.35 10.03 3170 947084 253517 89424676
Atrial fibrillation 40.26 10.03 1079 949175 132532 89545661
Acute graft versus host disease 40.14 10.03 5 950249 5463 89672730
Obesity 39.85 10.03 1416 948838 104091 89574102
Asthma-chronic obstructive pulmonary disease overlap syndrome 39.85 10.03 3 950251 4896 89673297
Tumour lysis syndrome 39.72 10.03 35 950219 11117 89667076
Cerebral infarction 39.70 10.03 144 950110 26452 89651741
Pulmonary arterial hypertension 39.61 10.03 141 950113 26046 89652147
Cytopenia 39.32 10.03 77 950177 17372 89660821
Neuropathy peripheral 38.99 10.03 1115 949139 135855 89542338
Jaundice cholestatic 38.91 10.03 29 950225 10014 89668179
Acute graft versus host disease in skin 38.44 10.03 3 950251 4753 89673440
Paradoxical drug reaction 38.37 10.03 7 950247 5759 89672434
Abnormal behaviour 38.26 10.03 116 950138 22512 89655681
Toxic epidermal necrolysis 38.18 10.03 193 950061 32335 89645858
Rash maculo-papular 37.89 10.03 262 949992 40671 89637522
Hypoaesthesia 37.79 10.03 3805 946449 310405 89367788
Pathogen resistance 37.60 10.03 19 950235 8096 89670097
Vision blurred 37.46 10.03 875 949379 109418 89568775
Autoimmune disorder 37.11 10.03 1061 949193 75683 89602510
Fluid retention 36.99 10.03 675 949579 87416 89590777
Tardive dyskinesia 36.92 10.03 36 950218 10894 89667299
Acute respiratory failure 36.70 10.03 281 949973 42637 89635556
Melaena 36.69 10.03 214 950040 34583 89643610
Forced expiratory volume decreased 36.66 10.03 8 950246 5800 89672393
Cytomegalovirus infection reactivation 36.54 10.03 18 950236 7782 89670411
Transaminases increased 36.47 10.03 234 950020 36958 89641235
Epstein-Barr virus infection 36.20 10.03 33 950221 10311 89667882
Blood pressure decreased 35.97 10.03 560 949694 74335 89603858
Infective pulmonary exacerbation of cystic fibrosis 35.72 10.03 33 950221 10246 89667947
Infection 35.71 10.03 4328 945926 357766 89320427
Gestational diabetes 35.58 10.03 211 950043 10371 89667822
Hyperbilirubinaemia 35.47 10.03 57 950197 13879 89664314
Prescribed underdose 35.41 10.03 1034 949220 73985 89604208
Adverse event 35.24 10.03 1537 948717 115881 89562312
Sciatica 35.23 10.03 1348 948906 100034 89578159
Substance abuse 35.04 10.03 7 950247 5399 89672794
Palpitations 34.98 10.03 1129 949125 135599 89542594
Muscle twitching 34.85 10.03 133 950121 24069 89654124
Foetal exposure during pregnancy 34.84 10.03 639 949615 42336 89635857
Myopathy 34.68 10.03 55 950199 13463 89664730
Speech disorder 34.63 10.03 308 949946 45277 89632916
Anuria 34.61 10.03 64 950190 14754 89663439
Wound infection 34.46 10.03 1404 948850 104998 89573195
Neck deformity 34.42 10.03 73 950181 2116 89676077
Adjustment disorder with depressed mood 34.25 10.03 808 949446 55945 89622248
Second primary malignancy 34.12 10.03 35 950219 10343 89667850
Cardiotoxicity 33.53 10.03 42 950212 11347 89666846
Musculoskeletal pain 33.49 10.03 2153 948101 169098 89509095
Wheelchair user 33.46 10.03 166 950088 7619 89670574
Haemorrhage intracranial 33.23 10.03 68 950186 15094 89663099
Drug dose omission by device 33.08 10.03 35 950219 10196 89667997
Subarachnoid haemorrhage 33.06 10.03 88 950166 17816 89660377
Rebound effect 32.76 10.03 30 950224 9354 89668839
Product administered to patient of inappropriate age 32.40 10.03 5 950249 4648 89673545
Graft versus host disease in gastrointestinal tract 32.24 10.03 4 950250 4384 89673809
Erythema multiforme 32.20 10.03 49 950205 12197 89665996
Cytomegalovirus viraemia 31.93 10.03 20 950234 7566 89670627
Myocarditis 31.92 10.03 60 950194 13746 89664447
Ischaemic stroke 31.79 10.03 122 950132 22044 89656149
Caesarean section 31.69 10.03 316 949938 18261 89659932
Dehydration 31.58 10.03 1691 948563 192756 89485437
White blood cell count decreased 31.47 10.03 1431 948823 165678 89512515
Atrioventricular block complete 31.23 10.03 34 950220 9777 89668416
Gastrointestinal haemorrhage 31.20 10.03 714 949540 89534 89588659
Chronic kidney disease 31.13 10.03 356 949898 49835 89628358
Atrial tachycardia 30.95 10.03 12 950242 5978 89672215
Bone marrow failure 30.94 10.03 204 950050 32017 89646176
Bradyphrenia 30.78 10.03 21 950233 7591 89670602
Septic shock 30.77 10.03 660 949594 83500 89594693
Pulseless electrical activity 30.66 10.03 29 950225 8903 89669290
Dislocation of vertebra 30.54 10.03 786 949468 55182 89623011
Metastases to lymph nodes 30.52 10.03 47 950207 11642 89666551
Device use error 30.45 10.03 19 950235 7202 89670991
Accidental overdose 30.28 10.03 173 950081 28100 89650093
Diabetes mellitus 30.18 10.03 488 949766 64387 89613806
Pemphigoid 30.18 10.03 30 950224 8996 89669197
Genital haemorrhage 30.17 10.03 28 950226 8674 89669519
C-reactive protein increased 30.14 10.03 2250 948004 179139 89499054
Electrocardiogram QRS complex prolonged 30.07 10.03 20 950234 7328 89670865
Injection site reaction 30.04 10.03 1216 949038 90864 89587329
Fear 29.72 10.03 83 950171 16539 89661654
Blood pressure diastolic decreased 29.67 10.03 420 949834 26406 89651787
Joint stiffness 29.62 10.03 1048 949206 76994 89601199
Gait inability 29.50 10.03 1846 948408 144610 89533583
Pulmonary alveolar haemorrhage 29.40 10.03 13 950241 5985 89672208
Leukocytosis 29.36 10.03 197 950057 30793 89647400
Irritability 29.32 10.03 236 950018 35426 89642767
Mucormycosis 29.29 10.03 3 950251 3818 89674375
Ketoacidosis 29.25 10.03 11 950243 5584 89672609
Hypercholesterolaemia 29.24 10.03 1316 948938 99576 89578617
Cardiomyopathy 29.12 10.03 111 950143 20095 89658098
Adjustment disorder 29.11 10.03 187 950067 9455 89668738
Road traffic accident 29.08 10.03 1394 948860 106232 89571961
Toxic encephalopathy 28.98 10.03 29 950225 8670 89669523
Schizoaffective disorder 28.85 10.03 9 950245 5138 89673055
Neurologic neglect syndrome 28.85 10.03 175 950079 8672 89669521
Purpura 28.54 10.03 71 950183 14707 89663486
Carotid artery thrombosis 28.48 10.03 178 950076 8914 89669279
Transplant dysfunction 28.27 10.03 10 950244 5272 89672921
Ventricular septal defect 28.19 10.03 122 950132 5285 89672908
Osteoporosis 28.17 10.03 1260 948994 95271 89582922
Dry skin 27.92 10.03 706 949548 87367 89590826
Total lung capacity increased 27.75 10.03 9 950245 5012 89673181
Lethargy 27.71 10.03 480 949774 62659 89615534
Gastroenteritis viral 27.71 10.03 460 949794 29895 89648298
Small for dates baby 27.68 10.03 115 950139 4892 89673301
Chronic graft versus host disease 27.59 10.03 5 950249 4134 89674059
Multiple fractures 27.38 10.03 183 950071 9379 89668814
Generalised tonic-clonic seizure 27.33 10.03 234 950020 34669 89643524
Emotional distress 27.29 10.03 249 950005 36413 89641780
Body temperature decreased 27.20 10.03 375 949879 23441 89654752
Graft versus host disease in skin 27.15 10.03 4 950250 3849 89674344
Haemorrhage 27.13 10.03 538 949716 68831 89609362
Bone pain 26.95 10.03 472 949782 61511 89616682
Nodule 26.84 10.03 411 949843 26275 89651918
Psychomotor hyperactivity 26.80 10.03 59 950195 12754 89665439
Deep vein thrombosis 26.79 10.03 743 949511 90877 89587316
Bone erosion 26.46 10.03 736 949518 52285 89625908
Peripheral venous disease 26.40 10.03 1104 949150 82817 89595376
Anosognosia 26.40 10.03 3 950251 3519 89674674
Adenovirus infection 26.05 10.03 8 950246 4614 89673579
Premature labour 26.04 10.03 234 950020 13142 89665051
Respiratory acidosis 26.00 10.03 28 950226 8091 89670102
Hyperthermia 25.62 10.03 43 950211 10292 89667901
Dyskinesia 25.54 10.03 252 950002 36282 89641911
Dry mouth 25.25 10.03 2250 948004 181809 89496384
Hyperlipidaemia 25.21 10.03 139 950115 22777 89655416
Muscle rigidity 25.17 10.03 72 950182 14237 89663956
Blood urea increased 25.13 10.03 201 950053 30212 89647981
Renal tubular necrosis 25.05 10.03 74 950180 14481 89663712
Acute coronary syndrome 24.99 10.03 47 950207 10766 89667427
C-reactive protein 24.94 10.03 465 949789 30902 89647291
Spinal stenosis 24.88 10.03 286 949968 17138 89661055
Pancreatitis 24.83 10.03 550 949704 69276 89608917
Eosinophilia 24.78 10.03 186 950068 28347 89649846
Bradypnoea 24.62 10.03 9 950245 4649 89673544
Oral candidiasis 24.60 10.03 245 950009 35210 89642983
Tubulointerstitial nephritis 24.57 10.03 160 950094 25183 89653010
Disability 24.56 10.03 580 949674 40165 89638028
Product administration error 24.52 10.03 169 950085 26254 89651939
Hallucination, visual 24.36 10.03 142 950112 22950 89655243
Flushing 24.26 10.03 724 949530 87767 89590426
Vertigo 24.22 10.03 552 949702 69259 89608934
Drug tolerance 24.22 10.03 291 949963 17625 89660568
Sexual dysfunction 24.20 10.03 10 950244 4794 89673399
Pulmonary haemorrhage 24.17 10.03 29 950225 7984 89670209
Paranoia 24.17 10.03 63 950191 12845 89665348
Pallor 24.16 10.03 235 950019 33930 89644263
Hallucinations, mixed 24.14 10.03 16 950238 5873 89672320
Rheumatoid nodule 24.05 10.03 320 949934 19846 89658347
Enthesopathy 24.00 10.03 175 950079 9229 89668964
Device related infection 23.89 10.03 165 950089 25621 89652572
Sinus bradycardia 23.87 10.03 94 950160 16858 89661335
Haematoma 23.81 10.03 278 949976 38770 89639423
Balance disorder 23.79 10.03 806 949448 96274 89581919
Haemodynamic instability 23.78 10.03 55 950199 11684 89666509
Hepatitis acute 23.71 10.03 49 950205 10838 89667355
Breast cancer stage III 23.71 10.03 1098 949156 83349 89594844
Ankylosing spondylitis 23.68 10.03 226 950028 12907 89665286
Acute myocardial infarction 23.42 10.03 243 950011 34647 89643546
Haematochezia 23.41 10.03 565 949689 70348 89607845
Aspiration 23.40 10.03 85 950169 15608 89662585
Device dislocation 23.35 10.03 214 950040 31268 89646925
Skin toxicity 23.28 10.03 22 950232 6757 89671436
Acidosis 23.21 10.03 63 950191 12673 89665520
Pulmonary hypertension 23.21 10.03 310 949944 42213 89635980
Immune effector cell-associated neurotoxicity syndrome 23.20 10.03 16 950238 5752 89672441
Blood lactic acid increased 23.20 10.03 35 950219 8743 89669450
Paralysis 23.08 10.03 54 950200 11424 89666769
Bacteraemia 23.06 10.03 138 950116 22162 89656031
Blood lactate dehydrogenase increased 23.02 10.03 168 950086 25764 89652429
Lower limb fracture 22.94 10.03 1101 949153 83912 89594281
Anti-cyclic citrullinated peptide antibody 22.85 10.03 407 949847 26814 89651379
Colitis microscopic 22.84 10.03 52 950202 11107 89667086
Dissociation 22.82 10.03 22 950232 6693 89671500
Klebsiella infection 22.72 10.03 46 950208 10251 89667942
Swelling face 22.70 10.03 664 949590 80688 89597505
Skin cancer 22.60 10.03 229 950025 13290 89664903
Acute chest syndrome 22.52 10.03 42 950212 1106 89677087
Myocardial ischaemia 22.52 10.03 72 950182 13742 89664451
Ileus 22.51 10.03 93 950161 16453 89661740
Nephrectomy 22.33 10.03 58 950196 1923 89676270
Maternal drugs affecting foetus 22.21 10.03 110 950144 5045 89673148
Hepatitis B reactivation 22.18 10.03 7 950247 3967 89674226
Localised infection 22.18 10.03 484 949770 33078 89645115
Tuberculosis 22.16 10.03 215 950039 12334 89665859
Eye pruritus 22.11 10.03 196 950058 28831 89649362
Glycosylated haemoglobin increased 22.10 10.03 86 950168 15476 89662717
Hyperprolactinaemia 21.95 10.03 15 950239 5418 89672775
Breast cancer metastatic 21.89 10.03 83 950171 15049 89663144
Acute pulmonary oedema 21.83 10.03 42 950212 9538 89668655
Hyperuricaemia 21.71 10.03 23 950231 6696 89671497
Nightmare 21.65 10.03 136 950118 21589 89656604
Lip swelling 21.61 10.03 280 949974 38330 89639863
Tenderness 21.60 10.03 399 949855 26469 89651724
Oropharyngeal pain 21.58 10.03 1443 948811 113744 89564449
Hypernatraemia 21.52 10.03 41 950213 9346 89668847
Coronary artery disease 21.43 10.03 237 950017 33386 89644807
Complication associated with device 21.38 10.03 118 950136 19331 89658862
Sleep terror 21.37 10.03 10 950244 4454 89673739
Hypoglycaemic coma 21.31 10.03 3 950251 2987 89675206
Pulmonary congestion 21.31 10.03 118 950136 19315 89658878
Injection site erythema 21.22 10.03 1249 949005 97253 89580940
Injection site pruritus 21.19 10.03 726 949528 53108 89625085
Diabetes insipidus 21.16 10.03 4 950250 3208 89674985
Drug tolerance decreased 21.12 10.03 463 949791 31667 89646526
Hyperammonaemia 21.10 10.03 22 950232 6453 89671740
Labelled drug-drug interaction medication error 21.08 10.03 80 950174 14502 89663691
Pulmonary toxicity 21.05 10.03 57 950197 11474 89666719
Rhinovirus infection 20.89 10.03 19 950235 5944 89672249
Cyanosis 20.86 10.03 119 950135 19336 89658857
Hepatic necrosis 20.84 10.03 22 950232 6416 89671777
Hypogammaglobulinaemia 20.84 10.03 51 950203 10623 89667570
Renal injury 20.74 10.03 48 950206 10195 89667998
Rectal haemorrhage 20.74 10.03 685 949569 82059 89596134
Gait disturbance 20.71 10.03 3074 947180 257422 89420771
Urinary retention 20.66 10.03 275 949979 37469 89640724
Laryngitis 20.63 10.03 687 949567 50066 89628127
Femur fracture 20.62 10.03 631 949623 45451 89632742
Body temperature increased 20.57 10.03 337 949917 44373 89633820
Neck mass 20.56 10.03 88 950166 3794 89674399
Immune reconstitution inflammatory syndrome 20.54 10.03 26 950228 6993 89671200
Eczema 20.39 10.03 411 949843 52459 89625734
Blood pressure diastolic increased 20.33 10.03 216 950038 12690 89665503
Atrial septal defect 20.32 10.03 152 950102 8082 89670111
Hyperlactacidaemia 20.22 10.03 9 950245 4127 89674066
Dermatitis exfoliative 20.17 10.03 17 950237 5519 89672674
Dysmorphism 20.10 10.03 66 950188 2502 89675691
Asthenia 20.03 10.03 5131 945123 528620 89149573
Oliguria 19.78 10.03 52 950202 10572 89667621
Creatinine renal clearance increased 19.76 10.03 5 950249 3276 89674917
Maternal exposure before pregnancy 19.74 10.03 192 950062 11021 89667172
Smear cervix abnormal 19.65 10.03 75 950179 3067 89675126
Sputum discoloured 19.63 10.03 129 950125 20262 89657931
Chronic disease 19.60 10.03 17 950237 198 89677995
Intestinal stenosis 19.53 10.03 77 950177 3197 89674996
Dysphagia 19.44 10.03 970 949284 111308 89566885
Hyperpyrexia 19.43 10.03 13 950241 4748 89673445
Hypoalbuminaemia 19.42 10.03 93 950161 15804 89662389
Maternal exposure during delivery 19.39 10.03 8 950246 3838 89674355
Intervertebral disc degeneration 19.33 10.03 271 949983 17003 89661190
Right ventricular failure 19.25 10.03 120 950134 19085 89659108
Systemic inflammatory response syndrome 19.21 10.03 24 950230 6492 89671701
Chills 19.19 10.03 1160 949094 130821 89547372
Rotator cuff repair 19.15 10.03 63 950191 2391 89675802
Loss of employment 19.09 10.03 4 950250 2983 89675210
Anti-neutrophil cytoplasmic antibody positive vasculitis 19.03 10.03 9 950245 3984 89674209
Postoperative wound infection 19.00 10.03 220 950034 13206 89664987
Epistaxis 18.98 10.03 715 949539 84410 89593783
Bursitis 18.92 10.03 1615 948639 130039 89548154
Limb deformity 18.90 10.03 90 950164 4062 89674131
Breast cancer female 18.83 10.03 86 950168 14800 89663393
Premature rupture of membranes 18.80 10.03 111 950143 5447 89672746
Blood pressure increased 18.73 10.03 2352 947902 194865 89483328
Reversible cerebral vasoconstriction syndrome 18.65 10.03 10 950244 4120 89674073
Dizziness 18.52 10.03 5708 944546 583576 89094617
Abortion incomplete 18.50 10.03 5 950249 3135 89675058
Cholecystitis chronic 18.37 10.03 48 950206 9778 89668415
Systemic candida 18.35 10.03 15 950239 4944 89673249
Clostridium difficile colitis 18.34 10.03 185 950069 26521 89651672
Enterocolitis 18.30 10.03 53 950201 10437 89667756
Epstein-Barr virus associated lymphoproliferative disorder 18.27 10.03 3 950251 2664 89675529
Hepatitis cholestatic 18.25 10.03 39 950215 8522 89669671
Mental disorder 18.22 10.03 234 950020 32084 89646109
Activated partial thromboplastin time prolonged 18.10 10.03 34 950220 7791 89670402
Varicella zoster virus infection 18.08 10.03 9 950245 3868 89674325
Abdominal pain 18.05 10.03 3769 946485 391952 89286241
Exposure via skin contact 18.01 10.03 55 950199 10650 89667543
Pregnancy with contraceptive device 17.92 10.03 16 950238 5050 89673143
Right aortic arch 17.87 10.03 17 950237 225 89677968
Pruritus genital 17.87 10.03 13 950241 4545 89673648
Malignant mediastinal neoplasm 17.73 10.03 43 950211 1365 89676828
COVID-19 17.73 10.03 1526 948728 167317 89510876
Disturbance in social behaviour 17.69 10.03 11 950243 4177 89674016
Middle insomnia 17.67 10.03 103 950151 16648 89661545
Cystitis haemorrhagic 17.67 10.03 19 950235 5494 89672699
Lymphopenia 17.64 10.03 154 950100 22727 89655466
Potentiating drug interaction 17.61 10.03 20 950234 5642 89672551
Pneumatosis intestinalis 17.57 10.03 7 950247 3430 89674763
Brain injury 17.56 10.03 34 950220 7704 89670489
X-ray abnormal 17.49 10.03 611 949643 44813 89633380
Product prescribing error 17.47 10.03 217 950037 29928 89648265
Nephropathy toxic 17.45 10.03 71 950183 12617 89665576
Anxiety 17.42 10.03 2918 947336 306854 89371339
Nocardiosis 17.36 10.03 3 950251 2567 89675626
Respiratory disorder 17.35 10.03 532 949722 64284 89613909
Sleep disorder 17.33 10.03 2350 947904 195680 89482513
Uterine perforation 17.31 10.03 33 950221 7521 89670672
Intracranial pressure increased 17.20 10.03 28 950226 6783 89671410
Feeling abnormal 17.18 10.03 1514 948740 165721 89512472
Hepatitis fulminant 17.17 10.03 10 950244 3935 89674258
Hepatic encephalopathy 17.16 10.03 80 950174 13692 89664501
Pericardial effusion 17.15 10.03 277 949977 36556 89641637
Generalised oedema 17.12 10.03 123 950131 18930 89659263
Cerebral haematoma 17.12 10.03 12 950242 4277 89673916
Joint dislocation 16.99 10.03 599 949655 43983 89634210
Visual acuity reduced 16.99 10.03 160 950094 23250 89654943
Latent tuberculosis 16.96 10.03 69 950185 2907 89675286
Skin papilloma 16.88 10.03 109 950145 5521 89672672
Dyspnoea exertional 16.83 10.03 604 949650 71684 89606509
Metabolic disorder 16.80 10.03 33 950221 7437 89670756
Bezoar 16.79 10.03 4 950250 2730 89675463
Laryngeal oedema 16.72 10.03 29 950225 6852 89671341
Subdural haematoma 16.69 10.03 104 950150 16541 89661652
Peripheral sensory neuropathy 16.68 10.03 46 950208 9204 89668989
Back pain 16.65 10.03 2999 947255 314176 89364017
Polyuria 16.60 10.03 52 950202 9988 89668205
Lymphoedema 16.49 10.03 81 950173 13672 89664521
Developmental hip dysplasia 16.45 10.03 45 950209 1540 89676653
Lupus-like syndrome 16.38 10.03 647 949607 48199 89629994
Synovial cyst 16.38 10.03 192 950062 11560 89666633
Pharyngitis streptococcal 16.37 10.03 205 950049 12537 89665656
Osteonecrosis 16.32 10.03 186 950068 26055 89652138
Cough 16.27 10.03 3520 946734 365442 89312751
Metastases to peritoneum 16.09 10.03 12 950242 4143 89674050
Neoplasm recurrence 16.07 10.03 7 950247 3252 89674941
Hepatocellular carcinoma 16.04 10.03 3 950251 2425 89675768
Cross sensitivity reaction 16.01 10.03 5 950249 2852 89675341
Synovial disorder 15.99 10.03 70 950184 3048 89675145
Placental disorder 15.99 10.03 45 950209 1566 89676627
Dysgeusia 15.94 10.03 424 949830 52136 89626057
Staphylococcal sepsis 15.94 10.03 48 950206 9335 89668858
Shock haemorrhagic 15.93 10.03 70 950184 12175 89666018
Hypophagia 15.84 10.03 273 949981 35664 89642529
Rhinorrhoea 15.77 10.03 1102 949152 87214 89590979
Bone lesion 15.76 10.03 27 950227 6410 89671783
Hypervolaemia 15.70 10.03 245 950009 32512 89645681
Product preparation error 15.69 10.03 55 950199 10206 89667987
Progressive multifocal leukoencephalopathy 15.60 10.03 98 950156 15557 89662636
Panic attack 15.58 10.03 189 950065 26176 89652017
Tinnitus 15.47 10.03 339 949915 42763 89635430
Hypercapnia 15.45 10.03 29 950225 6648 89671545
Pneumonitis 15.39 10.03 349 949905 43821 89634372
Skin ulcer 15.35 10.03 657 949597 49418 89628775
Throat tightness 15.35 10.03 217 950037 29267 89648926
Kidney transplant rejection 15.28 10.03 17 950237 4840 89673353
Congestive cardiomyopathy 15.27 10.03 34 950220 7320 89670873
Hypocalcaemia 15.27 10.03 333 949921 42035 89636158
Cleft lip and palate 15.26 10.03 28 950226 728 89677465
Treatment noncompliance 15.24 10.03 419 949835 51308 89626885
Rheumatoid lung 15.23 10.03 84 950170 4019 89674174
Heparin-induced thrombocytopenia 15.21 10.03 20 950234 5292 89672901
Onychomycosis 15.21 10.03 506 949748 36870 89641323
Ejection fraction abnormal 15.20 10.03 59 950195 2432 89675761
Malignant melanoma 15.18 10.03 200 950054 12376 89665817
Laryngospasm 15.15 10.03 8 950246 3325 89674868
Immunosuppressant drug level increased 15.14 10.03 16 950238 4664 89673529
Ear infection 15.08 10.03 885 949369 68890 89609303
Drug ineffective 15.03 10.03 13864 936390 1370434 88307759
Type 1 diabetes mellitus 14.96 10.03 17 950237 4795 89673398
Device malfunction 14.96 10.03 144 950110 20833 89657360
Haematuria 14.88 10.03 267 949987 34670 89643523
Foetal anticonvulsant syndrome 14.85 10.03 26 950228 651 89677542
Metastasis 14.79 10.03 26 950228 6111 89672082
Cholelithiasis 14.79 10.03 428 949826 52078 89626115
Cyst 14.76 10.03 250 950004 16311 89661882
Sensory loss 14.73 10.03 269 949985 17806 89660387
Pseudomonal sepsis 14.73 10.03 14 950240 4288 89673905
Tenosynovitis stenosans 14.72 10.03 81 950173 3872 89674321
Wrong product administered 14.67 10.03 37 950217 7628 89670565
Complication of device removal 14.62 10.03 27 950227 6228 89671965
Body height below normal 14.60 10.03 53 950201 2115 89676078
Device deployment issue 14.56 10.03 18 950236 4891 89673302
Intestinal resection 14.47 10.03 65 950189 2862 89675331
Glomerular filtration rate decreased 14.41 10.03 111 950143 16821 89661372
Tendonitis 14.37 10.03 309 949945 21063 89657130
Bundle branch block left 14.37 10.03 39 950215 7846 89670347
Pneumothorax 14.34 10.03 130 950124 19037 89659156
Poor venous access 14.34 10.03 286 949968 19241 89658952
Atrioventricular block 14.33 10.03 46 950208 8769 89669424
Facial paralysis 14.10 10.03 100 950154 15434 89662759
Vitamin B12 deficiency 14.08 10.03 130 950124 7356 89670837
Osteolysis 14.08 10.03 10 950244 3540 89674653
Immunisation 14.07 10.03 3 950251 2210 89675983
Nail operation 14.04 10.03 48 950206 1858 89676335
Benign neoplasm of adrenal gland 14.03 10.03 8 950246 44 89678149
Left ventricular dysfunction 14.02 10.03 93 950161 14576 89663617
Device breakage 13.95 10.03 88 950166 13956 89664237
Foot operation 13.88 10.03 150 950104 8851 89669342
Cardiac failure acute 13.88 10.03 71 950183 11858 89666335
Lupus vulgaris 13.77 10.03 591 949663 44468 89633725
Antibody test positive 13.76 10.03 65 950189 2924 89675269
Influenza 13.76 10.03 1665 948589 137599 89540594
Loose body in joint 13.75 10.03 39 950215 1363 89676830
Nystagmus 13.74 10.03 35 950219 7192 89671001
Ventricular arrhythmia 13.73 10.03 15 950239 4306 89673887
Product complaint 13.72 10.03 84 950170 13416 89664777
Type I hypersensitivity 13.67 10.03 14 950240 4141 89674052
Copper deficiency 13.64 10.03 11 950243 115 89678078
Immune-mediated enterocolitis 13.53 10.03 18 950236 4739 89673454
Synovial fluid analysis 13.50 10.03 62 950192 2756 89675437
Eosinophil count increased 13.50 10.03 81 950173 13000 89665193
Immune-mediated hepatitis 13.48 10.03 7 950247 2937 89675256
Congenital arterial malformation 13.48 10.03 17 950237 314 89677879
Ventricular hypokinesia 13.45 10.03 22 950232 5319 89672874
Carotid artery occlusion 13.43 10.03 29 950225 6313 89671880
Vascular device infection 13.42 10.03 72 950182 11880 89666313
Polyhydramnios 13.39 10.03 57 950197 2451 89675742
Breast feeding 13.37 10.03 29 950225 854 89677339
Anticholinergic syndrome 13.36 10.03 6 950248 2737 89675456
Gene mutation 13.31 10.03 3 950251 2127 89676066
Hypotonia 13.29 10.03 68 950186 11358 89666835
Benign ovarian tumour 13.29 10.03 21 950233 482 89677711
Magnesium deficiency 13.27 10.03 26 950228 711 89677482
Exostosis 13.27 10.03 683 949571 52451 89625742
Purging 13.22 10.03 8 950246 50 89678143
Breast cancer stage I 13.15 10.03 54 950200 9570 89668623
Metabolic surgery 13.15 10.03 42 950212 1569 89676624
Catheter site pain 13.12 10.03 24 950230 5555 89672638
Product substitution issue 13.10 10.03 123 950131 17885 89660308
Secondary adrenocortical insufficiency 13.09 10.03 4 950250 2314 89675879
Seronegative arthritis 13.04 10.03 266 949988 17968 89660225
Dependence 12.99 10.03 3 950251 2092 89676101
Blindness 12.98 10.03 198 950056 26370 89651823
Autoimmune hepatitis 12.97 10.03 60 950194 10291 89667902
Acute graft versus host disease in intestine 12.89 10.03 3 950251 2080 89676113
Hyperreflexia 12.84 10.03 32 950222 6625 89671568
Complication of device insertion 12.78 10.03 61 950193 10375 89667818
Squamous cell carcinoma 12.76 10.03 162 950092 9939 89668254
Personality change 12.76 10.03 37 950217 7284 89670909
Product prescribing issue 12.72 10.03 42 950212 7937 89670256
Linear IgA disease 12.70 10.03 4 950250 2270 89675923
Cholecystitis acute 12.70 10.03 53 950201 9351 89668842
Incorrect dose administered 12.69 10.03 687 949567 78243 89599950
Staphylococcal infection 12.62 10.03 399 949855 48040 89630153
Skin burning sensation 12.59 10.03 138 950116 19473 89658720
Neutrophilia 12.59 10.03 26 950228 5752 89672441
Lung disorder 12.54 10.03 1774 948480 148109 89530084
Hepatic cirrhosis 12.49 10.03 796 949458 62457 89615736
Metamyelocyte count increased 12.49 10.03 13 950241 193 89678000
Candida infection 12.47 10.03 267 949987 33790 89644403
Antinuclear antibody positive 12.45 10.03 150 950104 9091 89669102
Soft tissue disorder 12.44 10.03 16 950238 4274 89673919
End stage renal disease 12.40 10.03 47 950207 8524 89669669
Drug effective for unapproved indication 12.40 10.03 42 950212 7876 89670317
Injection site bruising 12.38 10.03 669 949585 51638 89626555
Limb reduction defect 12.35 10.03 23 950231 605 89677588
Bundle branch block right 12.34 10.03 24 950230 5429 89672764
Bone density abnormal 12.32 10.03 80 950174 4060 89674133
Crying 12.23 10.03 192 950062 25453 89652740
Dermatitis bullous 12.23 10.03 61 950193 10255 89667938
Paronychia 12.18 10.03 43 950211 7963 89670230
Nasal obstruction 12.17 10.03 57 950197 2555 89675638
Pyelonephritis 12.14 10.03 154 950100 21162 89657031
Amyloid arthropathy 12.11 10.03 42 950212 1638 89676555
Bronchial secretion retention 12.10 10.03 12 950242 3603 89674590
Endophthalmitis 12.08 10.03 19 950235 4666 89673527
Hypertelorism 12.08 10.03 21 950233 523 89677670
Capillary leak syndrome 12.06 10.03 7 950247 2760 89675433
Bradykinesia 12.06 10.03 34 950220 6754 89671439
Polydipsia 12.05 10.03 16 950238 4215 89673978
Spinal osteoarthritis 11.98 10.03 274 949980 18874 89659319
Fracture delayed union 11.90 10.03 55 950199 2451 89675742
International normalised ratio fluctuation 11.89 10.03 9 950245 3084 89675109
Metastases to spine 11.88 10.03 13 950241 3730 89674463
Pulmonary function test abnormal 11.84 10.03 7 950247 2732 89675461
Clear cell renal cell carcinoma 11.83 10.03 40 950214 1540 89676653
Cartilage injury 11.82 10.03 49 950205 2082 89676111
Euglycaemic diabetic ketoacidosis 11.82 10.03 30 950224 6171 89672022
Ototoxicity 11.81 10.03 3 950251 1961 89676232
Cardiac failure chronic 11.81 10.03 26 950228 5620 89672573
Anosmia 11.81 10.03 58 950196 9790 89668403
Lip oedema 11.78 10.03 19 950235 4620 89673573
Arthritis infective 11.78 10.03 132 950122 7860 89670333
Pneumonia bacterial 11.77 10.03 82 950172 12708 89665485
Cardiopulmonary failure 11.76 10.03 16 950238 4172 89674021
Mood altered 11.67 10.03 119 950135 17025 89661168
Scleritis 11.66 10.03 94 950160 5114 89673079
Crohn's disease 11.66 10.03 89 950165 4762 89673431
Pneumocystis jirovecii pneumonia 11.64 10.03 158 950096 21458 89656735
Post procedural haemorrhage 11.63 10.03 50 950204 8748 89669445
Inadequate analgesia 11.62 10.03 10 950244 3214 89674979
Eosinophilic granulomatosis with polyangiitis 11.61 10.03 6 950248 2524 89675669
Infection reactivation 11.60 10.03 3 950251 1937 89676256
Eyelid oedema 11.60 10.03 72 950182 11462 89666731
Hypertriglyceridaemia 11.59 10.03 43 950211 7846 89670347
Spondylitis 11.55 10.03 211 950043 13967 89664226
Hypertransaminasaemia 11.55 10.03 108 950146 15717 89662476
Lung transplant 11.53 10.03 13 950241 3679 89674514
Retrognathia 11.53 10.03 21 950233 543 89677650
Red blood cell sedimentation rate 11.50 10.03 86 950168 4572 89673621
Tonsillar inflammation 11.49 10.03 10 950244 117 89678076
Human antichimeric antibody positive 11.47 10.03 43 950211 1743 89676450
Infusion site pain 11.47 10.03 142 950112 19596 89658597
Drug abuser 11.45 10.03 7 950247 2683 89675510
Skin lesion 11.44 10.03 301 949953 37064 89641129
Amylase increased 11.43 10.03 37 950217 7035 89671158
Dysuria 11.39 10.03 320 949934 39081 89639112
Myringotomy 11.30 10.03 6 950248 28 89678165
Wheezing 11.28 10.03 2737 947517 235343 89442850
Corneal oedema 11.25 10.03 3 950251 1898 89676295
Rectal abscess 11.25 10.03 38 950216 1462 89676731
Skin plaque 11.25 10.03 60 950194 9915 89668278
Product storage error 11.25 10.03 147 950107 20094 89658099
Electrolyte imbalance 11.25 10.03 178 950076 23567 89654626
Faecal calprotectin increased 11.23 10.03 76 950178 3911 89674282
Ankle arthroplasty 11.21 10.03 59 950195 2772 89675421
Hydronephrosis 11.18 10.03 80 950174 12322 89665871
Total lung capacity decreased 11.17 10.03 14 950240 3781 89674412
Dermatitis acneiform 11.16 10.03 32 950222 6322 89671871
Affective disorder 11.11 10.03 43 950211 7750 89670443
Hypertensive crisis 11.08 10.03 126 950128 17658 89660535
Pre-eclampsia 11.05 10.03 170 950084 10878 89667315
Hemianopia 11.04 10.03 4 950250 2078 89676115
Immune thrombocytopenia 11.04 10.03 88 950166 13238 89664955
Eye movement disorder 11.04 10.03 31 950223 6167 89672026
Venoocclusive disease 11.00 10.03 6 950248 2449 89675744
Pulse absent 11.00 10.03 30 950224 6025 89672168
Lymphatic fistula 10.95 10.03 37 950217 1424 89676769
Drug screen positive 10.91 10.03 14 950240 3743 89674450
Granulocytopenia 10.90 10.03 33 950221 6408 89671785
Hallucination, auditory 10.83 10.03 111 950143 15864 89662329
Iritis 10.83 10.03 71 950183 3615 89674578
Red blood cell count decreased 10.81 10.03 592 949662 45759 89632434
Colorectal cancer 10.80 10.03 15 950239 3878 89674315
Joint injury 10.80 10.03 432 949822 32232 89645961
Myofascial pain syndrome 10.79 10.03 61 950193 2946 89675247
Haemodialysis 10.79 10.03 51 950203 8696 89669497
Spinal cord compression 10.78 10.03 22 950232 4889 89673304
Haematemesis 10.78 10.03 270 949984 33456 89644737
Enterococcal infection 10.77 10.03 61 950193 9930 89668263
Metastases to meninges 10.76 10.03 14 950240 3721 89674472
Vasa praevia 10.71 10.03 3 950251 0 89678193
Ligamentitis 10.71 10.03 3 950251 0 89678193
Blood zinc increased 10.71 10.03 3 950251 0 89678193
Cutaneous vasculitis 10.70 10.03 39 950215 7154 89671039
Quadriplegia 10.68 10.03 5 950249 2226 89675967
Blood phosphorus decreased 10.68 10.03 23 950231 5011 89673182
Blood iron abnormal 10.65 10.03 16 950238 4004 89674189
Bone density increased 10.65 10.03 27 950227 882 89677311
Cystitis 10.64 10.03 825 949429 65893 89612300
Skin reaction 10.58 10.03 134 950120 18419 89659774
Discoloured vomit 10.58 10.03 32 950222 1160 89677033
Retinitis 10.57 10.03 499 949755 37959 89640234
Lymphocyte count decreased 10.56 10.03 283 949971 34767 89643426
Post procedural infection 10.55 10.03 169 950085 10905 89667288
Acrochordon 10.54 10.03 37 950217 1452 89676741
Neutropenic colitis 10.49 10.03 17 950237 4126 89674067
Aplasia 10.46 10.03 16 950238 3975 89674218
Multiple sclerosis relapse 10.44 10.03 445 949809 51860 89626333
Gastroschisis 10.43 10.03 17 950237 401 89677792
Personality disorder 10.43 10.03 186 950068 12258 89665935
Mouth ulceration 10.42 10.03 516 949738 39458 89638735
Persecutory delusion 10.34 10.03 11 950243 3197 89674996
Femoral hernia incarcerated 10.27 10.03 37 950217 1471 89676722
Dialysis 10.25 10.03 73 950181 11256 89666937
Ingrown hair 10.24 10.03 21 950233 594 89677599
Onychomadesis 10.24 10.03 585 949669 45413 89632780
Bacterial sepsis 10.21 10.03 23 950231 4932 89673261
Dyslipidaemia 10.21 10.03 63 950191 10044 89668149
Learning disorder 10.20 10.03 26 950228 852 89677341
Oligoarthritis 10.18 10.03 20 950234 548 89677645
Motor dysfunction 10.18 10.03 269 949985 18961 89659232
Soft tissue mass 10.13 10.03 16 950238 367 89677826
Ulcer haemorrhage 10.12 10.03 354 949900 25967 89652226
Gastrointestinal toxicity 10.10 10.03 58 950196 9409 89668784
Lower respiratory tract congestion 10.08 10.03 65 950189 3291 89674902

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 526.55 10.37 984 283044 41456 42295851
Drug abuse 452.11 10.37 77 283951 104694 42232613
Toxicity to various agents 438.96 10.37 529 283499 228607 42108700
Completed suicide 355.43 10.37 101 283927 96364 42240943
Drug interaction 309.61 10.37 841 283187 266158 42071149
Arthralgia 277.41 10.37 2324 281704 202914 42134393
Foetal exposure during pregnancy 237.69 10.37 775 283253 46536 42290771
Psoriatic arthropathy 204.75 10.37 489 283539 24478 42312829
Intentional overdose 146.59 10.37 80 283948 51376 42285931
Fatigue 137.27 10.37 3835 280193 431806 41905501
Product use in unapproved indication 129.45 10.37 711 283317 183745 42153562
Pain 128.36 10.37 2318 281710 242530 42094777
Psoriasis 125.45 10.37 648 283380 47956 42289351
Coma 123.53 10.37 105 283923 53449 42283858
Sickle cell anaemia with crisis 120.90 10.37 156 283872 4734 42332573
Joint swelling 120.19 10.37 821 283207 67201 42270106
Acute kidney injury 115.55 10.37 1738 282290 365599 41971708
Dysmorphism 111.99 10.37 124 283904 3192 42334115
Blood pressure fluctuation 111.82 10.37 414 283614 26494 42310813
Multiple organ dysfunction syndrome 110.40 10.37 308 283720 96727 42240580
Overdose 106.28 10.37 353 283675 104911 42232396
Serotonin syndrome 100.97 10.37 24 284004 25821 42311486
Weight decreased 99.67 10.37 1942 282086 206006 42131301
Arthritis 97.12 10.37 544 283484 41521 42295786
Blood pressure systolic increased 95.79 10.37 405 283623 27563 42309744
Rhabdomyolysis 95.30 10.37 239 283789 77780 42259527
Off label use 91.35 10.37 3409 280619 634926 41702381
Enthesopathy 87.95 10.37 133 283895 4695 42332612
Drug dependence 86.16 10.37 43 283985 29051 42308256
Musculoskeletal stiffness 84.73 10.37 667 283361 57098 42280209
Drug ineffective 84.34 10.37 3392 280636 626805 41710502
Hepatic function abnormal 81.65 10.37 136 283892 51431 42285876
Fall 80.23 10.37 2088 281940 232432 42104875
Drug resistance 79.16 10.37 67 283961 34181 42303126
Intentional product misuse 78.44 10.37 186 283842 61714 42275593
Disease progression 77.69 10.37 599 283429 143057 42194250
Peripheral swelling 74.74 10.37 925 283103 89345 42247962
Heart rate decreased 73.08 10.37 455 283573 36077 42301230
Small for dates baby 72.80 10.37 128 283900 5135 42332172
Sedation 72.44 10.37 58 283970 30417 42306890
Drug reaction with eosinophilia and systemic symptoms 70.36 10.37 107 283921 41968 42295339
Appendicolith 70.25 10.37 5 284023 13451 42323856
Synovitis 69.32 10.37 245 283783 15322 42321985
Blood pressure increased 67.76 10.37 1004 283024 100924 42236383
Arthropathy 65.83 10.37 379 283649 29218 42308089
Blood pressure systolic abnormal 65.80 10.37 126 283902 5402 42331905
Osteoarthritis 63.38 10.37 326 283702 24079 42313228
Pain in extremity 63.04 10.37 1379 282649 149225 42188082
Nasopharyngitis 62.91 10.37 845 283183 83151 42254156
Cytomegalovirus infection 61.24 10.37 75 283953 32231 42305076
Exposure during pregnancy 61.19 10.37 159 283869 8389 42328918
Altered state of consciousness 59.71 10.37 64 283964 29195 42308112
Premature baby 59.24 10.37 308 283720 22845 42314462
Haemoglobin decreased 58.99 10.37 1224 282804 131247 42206060
Respiratory failure 58.64 10.37 558 283470 127574 42209733
Tenosynovitis 58.34 10.37 109 283919 4586 42332721
Drug ineffective for unapproved indication 58.26 10.37 139 283889 46024 42291283
Speech disorder developmental 58.23 10.37 74 283954 2211 42335096
Cardiac arrest 58.07 10.37 458 283570 108862 42228445
Suicide attempt 55.68 10.37 142 283886 45958 42291349
Ventricular fibrillation 54.94 10.37 72 283956 30051 42307256
Respiratory arrest 52.81 10.37 67 283961 28357 42308950
C-reactive protein abnormal 52.26 10.37 158 283870 9103 42328204
Toxic epidermal necrolysis 51.87 10.37 61 283967 26689 42310618
Depressed level of consciousness 51.80 10.37 156 283872 47814 42289493
Neonatal respiratory distress syndrome 51.44 10.37 101 283927 4412 42332895
Foetal anticonvulsant syndrome 51.42 10.37 51 283977 1151 42336156
Abdominal discomfort 51.07 10.37 744 283284 74511 42262796
Hypoglycaemia neonatal 50.68 10.37 67 283961 2083 42335224
Angioedema 50.41 10.37 132 283896 42345 42294962
Blood pressure diastolic abnormal 50.20 10.37 120 283908 6008 42331299
Maternal exposure during pregnancy 48.12 10.37 128 283900 6850 42330457
Pathogen resistance 48.07 10.37 9 284019 11441 42325866
Asthenia 47.97 10.37 2309 281719 278484 42058823
Myelosuppression 47.81 10.37 126 283902 40335 42296972
Cardiogenic shock 47.65 10.37 104 283924 35536 42301771
Drug use disorder 45.86 10.37 7 284021 10326 42326981
Acute hepatic failure 45.15 10.37 29 283999 17044 42320263
Febrile neutropenia 44.93 10.37 920 283108 184783 42152524
Body temperature decreased 44.24 10.37 202 283826 14211 42323096
Suicidal ideation 44.24 10.37 168 283860 47993 42289314
Neck pain 44.23 10.37 347 283681 29667 42307640
Bradycardia 44.06 10.37 361 283667 85123 42252184
Renal impairment 43.88 10.37 496 283532 109732 42227575
Pulmonary alveolar haemorrhage 43.71 10.37 22 284006 14794 42322513
Back pain 43.48 10.37 1245 282783 140531 42196776
Blood pressure diastolic decreased 43.40 10.37 160 283868 10215 42327092
Vitamin B12 deficiency 43.17 10.37 99 283929 4823 42332484
Gait disturbance 43.11 10.37 904 283124 97096 42240211
Palmar-plantar erythrodysaesthesia syndrome 42.02 10.37 45 283983 20537 42316770
Alanine aminotransferase abnormal 41.78 10.37 98 283930 4846 42332461
Learning disorder 41.76 10.37 44 283984 1069 42336238
Aspergillus infection 41.74 10.37 27 284001 15810 42321497
Lactic acidosis 41.50 10.37 158 283870 45103 42292204
Maternal drugs affecting foetus 41.46 10.37 84 283944 3755 42333552
Hepatic failure 41.06 10.37 124 283904 37976 42299331
Therapy partial responder 40.62 10.37 44 283984 19977 42317330
Haematochezia 40.54 10.37 580 283448 57856 42279451
Electrocardiogram QT prolonged 40.41 10.37 173 283855 47772 42289535
Malignant neoplasm progression 39.99 10.37 496 283532 107904 42229403
Atrial septal defect 39.98 10.37 130 283898 7789 42329518
Appendicitis 39.97 10.37 47 283981 20566 42316741
Sopor 39.87 10.37 19 284009 13183 42324124
Renal failure 39.69 10.37 696 283332 143030 42194277
Substance abuse 39.60 10.37 6 284022 8899 42328408
Anaphylactic shock 39.13 10.37 60 283968 23457 42313850
Respiratory depression 38.80 10.37 41 283987 18827 42318480
Low birth weight baby 38.73 10.37 150 283878 9805 42327502
Cryptorchism 38.58 10.37 57 283971 1970 42335337
No adverse event 38.57 10.37 132 283896 38889 42298418
Ankylosing spondylitis 38.53 10.37 119 283909 6937 42330370
Skin cancer 38.48 10.37 165 283863 11297 42326010
Hypospadias 38.46 10.37 78 283950 3489 42333818
Colitis ulcerative 38.23 10.37 302 283726 25873 42311434
Cytokine release syndrome 37.94 10.37 160 283868 44367 42292940
Intercepted product preparation error 37.85 10.37 3 284025 7386 42329921
Frequent bowel movements 37.55 10.37 258 283770 21149 42316158
Autism spectrum disorder 36.67 10.37 69 283959 2919 42334388
Post transplant lymphoproliferative disorder 36.56 10.37 8 284020 9112 42328195
Rheumatoid nodule 36.55 10.37 69 283959 2926 42334381
Mucormycosis 36.31 10.37 3 284025 7140 42330167
Venoocclusive liver disease 35.73 10.37 12 284016 10290 42327017
Shock 35.70 10.37 89 283939 29032 42308275
Joint effusion 35.55 10.37 103 283925 5794 42331513
Jaundice neonatal 35.47 10.37 57 283971 2122 42335185
Cytomegalovirus infection reactivation 35.46 10.37 15 284013 11163 42326144
Neurotoxicity 35.05 10.37 65 283963 23586 42313721
Hypoglycaemia 34.99 10.37 244 283784 59610 42277697
Poisoning 34.90 10.37 28 284000 14671 42322636
Akathisia 34.83 10.37 13 284015 10438 42326869
Agitation 34.81 10.37 268 283760 64046 42273261
Grip strength decreased 34.65 10.37 75 283953 3513 42333794
Maternal exposure during breast feeding 34.43 10.37 47 283981 1508 42335799
Ascites 34.15 10.37 229 283799 56449 42280858
Blood pressure diastolic increased 34.03 10.37 107 283921 6298 42331009
Tachycardia 33.81 10.37 472 283556 100615 42236692
Joint range of motion decreased 33.64 10.37 121 283907 7632 42329675
Basal cell carcinoma 33.59 10.37 263 283765 22470 42314837
Metabolic acidosis 33.56 10.37 205 283823 51653 42285654
Cardiac failure 33.28 10.37 506 283522 106350 42230957
Syndactyly 33.25 10.37 36 283992 903 42336404
BK virus infection 32.69 10.37 9 284019 8775 42328532
Exposure via breast milk 32.66 10.37 59 283969 2418 42334889
Tongue disorder 32.43 10.37 94 283934 5289 42332018
Somnolence 32.36 10.37 705 283323 140400 42196907
Anal fissure 32.06 10.37 92 283936 5147 42332160
Finger deformity 31.15 10.37 46 283982 1589 42335718
Pancytopenia 31.02 10.37 1015 283013 116728 42220579
Incorrect route of product administration 30.81 10.37 73 283955 24232 42313075
Knee arthroplasty 30.71 10.37 128 283900 8653 42328654
Ventricular septal defect 30.64 10.37 81 283947 4318 42332989
Neuritis 30.58 10.37 3 284025 6217 42331090
Suspected suicide 30.45 10.37 3 284025 6196 42331111
Drug withdrawal syndrome 30.39 10.37 61 283967 21488 42315819
Musculoskeletal pain 30.36 10.37 348 283680 32992 42304315
Acute respiratory distress syndrome 30.33 10.37 101 283927 30007 42307300
Localised infection 30.27 10.37 236 283792 20137 42317170
Bradycardia neonatal 30.23 10.37 41 283987 1307 42336000
Neuroleptic malignant syndrome 30.09 10.37 61 283967 21411 42315896
Joint laxity 30.07 10.37 24 284004 402 42336905
Immune reconstitution inflammatory syndrome 30.02 10.37 15 284013 10128 42327179
Forced expiratory volume decreased 29.97 10.37 7 284021 7623 42329684
Full blood count decreased 29.90 10.37 237 283791 20323 42316984
Acute graft versus host disease 29.50 10.37 9 284019 8206 42329101
Hyperglycaemia 29.30 10.37 182 283846 45677 42291630
Proteinuria 29.15 10.37 69 283959 22914 42314393
Back disorder 29.05 10.37 113 283915 7401 42329906
Psychotic disorder 28.73 10.37 99 283929 29109 42308198
Cataract 28.57 10.37 321 283707 30283 42307024
Infusion related reaction 28.41 10.37 566 283462 60240 42277067
Foot deformity 28.16 10.37 86 283942 4982 42332325
Wound 28.09 10.37 203 283825 16914 42320393
Hand deformity 27.91 10.37 71 283957 3697 42333610
Hypoaesthesia 27.86 10.37 648 283380 70815 42266492
Influenza 27.81 10.37 575 283453 61600 42275707
Hypoxia 27.77 10.37 314 283714 69472 42267835
Delirium 27.42 10.37 221 283807 52298 42285009
Adenovirus infection 27.24 10.37 6 284022 6803 42330504
Blood phosphorus increased 27.15 10.37 26 284002 12499 42324808
Hyperbilirubinaemia neonatal 26.95 10.37 31 283997 833 42336474
Cytomegalovirus viraemia 26.93 10.37 18 284010 10359 42326948
Acute graft versus host disease in skin 26.90 10.37 8 284020 7416 42329891
Polyomavirus-associated nephropathy 26.85 10.37 3 284025 5612 42331695
Developmental delay 26.81 10.37 63 283965 3119 42334188
Hypermobility syndrome 26.80 10.37 21 284007 342 42336965
Conjunctivitis allergic 26.24 10.37 4 284024 5907 42331400
Contusion 26.11 10.37 409 283619 41576 42295731
Maternal exposure before pregnancy 26.06 10.37 34 283994 1043 42336264
Pyrexia 25.96 10.37 2267 281761 391775 41945532
Vitamin D decreased 25.45 10.37 77 283951 4438 42332869
Death 25.42 10.37 2751 281277 468434 41868873
Hypokalaemia 25.38 10.37 331 283697 71390 42265917
Red blood cell sedimentation rate increased 25.37 10.37 132 283896 9792 42327515
Ventricular tachycardia 25.31 10.37 109 283919 30051 42307256
Acute chest syndrome 24.81 10.37 33 283995 1032 42336275
Plagiocephaly 24.75 10.37 25 284003 577 42336730
Cystitis haemorrhagic 24.62 10.37 9 284019 7320 42329987
Dysgraphia 24.60 10.37 53 283975 2475 42334832
Nasal disorder 24.17 10.37 46 283982 1963 42335344
Intentional self-injury 24.14 10.37 40 283988 15162 42322145
Pulmonary vasculitis 24.12 10.37 6 284022 6260 42331047
Vomiting 24.05 10.37 1635 282393 288088 42049219
Pneumonia 24.05 10.37 3187 280841 418962 41918345
Spirometry abnormal 23.99 10.37 3 284025 5143 42332164
Mucocutaneous ulceration 23.89 10.37 23 284005 500 42336807
Vitamin B12 decreased 23.81 10.37 41 283987 1617 42335690
Disseminated intravascular coagulation 23.74 10.37 85 283943 24709 42312598
Agranulocytosis 23.67 10.37 114 283914 30498 42306809
Cardiotoxicity 23.60 10.37 10 284018 7435 42329872
Respiratory disorder neonatal 23.57 10.37 45 283983 1925 42335382
Electrocardiogram QRS complex prolonged 23.56 10.37 5 284023 5818 42331489
Balance disorder 23.44 10.37 447 283581 47198 42290109
Sinusitis 23.37 10.37 444 283584 46848 42290459
Haemangioma congenital 23.30 10.37 23 284005 516 42336791
Haematocrit decreased 23.22 10.37 344 283684 34564 42302743
Exposure to toxic agent 23.12 10.37 3 284025 5001 42332306
Arthritis infective 23.12 10.37 70 283958 4036 42333271
Septic shock 23.08 10.37 451 283577 91221 42246086
Talipes 23.05 10.37 48 283980 2188 42335119
Headache 23.04 10.37 1873 282155 237496 42099811
Congenital hand malformation 23.03 10.37 25 284003 629 42336678
Posterior reversible encephalopathy syndrome 23.02 10.37 31 283997 12790 42324517
Substance use disorder 22.87 10.37 4 284024 5341 42331966
Anal fistula 22.86 10.37 92 283936 6121 42331186
Dust allergy 22.80 10.37 4 284024 5328 42331979
Red blood cell count decreased 22.80 10.37 325 283703 32390 42304917
Inflammation 22.70 10.37 334 283694 33513 42303794
Urinary tract infection 22.67 10.37 842 283186 98442 42238865
Caesarean section 22.64 10.37 46 283982 2060 42335247
Neurological symptom 22.53 10.37 20 284008 9971 42327336
Pneumonia aspiration 22.49 10.37 219 283809 49859 42287448
Cardio-respiratory arrest 22.48 10.37 266 283762 58370 42278937
Thrombotic microangiopathy 22.46 10.37 40 283988 14742 42322565
Polyarthritis 22.44 10.37 80 283948 5024 42332283
Drug level increased 22.41 10.37 94 283934 26106 42311201
Drug withdrawal syndrome neonatal 22.31 10.37 73 283955 4388 42332919
Clostridium test positive 22.28 10.37 84 283944 5421 42331886
Aggression 22.07 10.37 188 283840 43975 42293332
Large for dates baby 21.95 10.37 29 283999 901 42336406
Rash maculo-papular 21.86 10.37 153 283875 37350 42299957
Vitamin D deficiency 21.77 10.37 109 283919 7964 42329343
Foetal growth restriction 21.70 10.37 81 283947 5202 42332105
Hyperkalaemia 21.44 10.37 392 283636 80066 42257241
Multiple-drug resistance 21.41 10.37 11 284017 7311 42329996
Haematotoxicity 21.35 10.37 25 284003 10960 42326347
Gamma-glutamyltransferase increased 21.27 10.37 128 283900 32369 42304938
Hyponatraemia 21.26 10.37 514 283514 100948 42236359
Haemoptysis 21.12 10.37 201 283827 45966 42291341
Poor venous access 21.05 10.37 100 283928 7152 42330155
Chronic graft versus host disease 20.93 10.37 7 284021 6018 42331289
Tendonitis 20.90 10.37 125 283903 9769 42327538
Myasthenia gravis 20.83 10.37 48 283980 16089 42321218
Weight increased 20.76 10.37 899 283129 107084 42230223
Joint stiffness 20.72 10.37 147 283881 12175 42325132
Heart rate irregular 20.66 10.37 180 283848 15870 42321437
Ultrasound antenatal screen 20.63 10.37 22 284006 542 42336765
Astigmatism 20.56 10.37 34 283994 1297 42336010
Mydriasis 20.45 10.37 17 284011 8753 42328554
Congenital oesophageal anomaly 20.41 10.37 11 284017 90 42337217
Plasma cell myeloma 20.29 10.37 437 283591 47141 42290166
Dyspraxia 20.11 10.37 20 284008 453 42336854
Agitation neonatal 20.10 10.37 35 283993 1393 42335914
Ileal stenosis 20.08 10.37 41 283987 1843 42335464
Nephrolithiasis 20.03 10.37 351 283677 36479 42300828
Potentiating drug interaction 20.01 10.37 9 284019 6459 42330848
Brain oedema 19.93 10.37 50 283978 16277 42321030
Language disorder 19.77 10.37 48 283980 2427 42334880
Infective pulmonary exacerbation of cystic fibrosis 19.70 10.37 14 284014 7804 42329503
Diaphragmatic disorder 19.61 10.37 32 283996 1207 42336100
Transplant rejection 19.56 10.37 38 283990 13550 42323757
Hydrops foetalis 19.50 10.37 27 284001 878 42336429
Nephropathy toxic 19.46 10.37 53 283975 16785 42320522
Syringe issue 19.45 10.37 17 284011 8539 42328768
Cerebral haemorrhage 19.41 10.37 166 283862 38800 42298507
Neck mass 19.41 10.37 40 283988 1810 42335497
Mobility decreased 19.39 10.37 337 283691 34969 42302338
Spinal disorder 19.37 10.37 71 283957 4520 42332787
Head discomfort 19.32 10.37 77 283951 5100 42332207
Seizure 19.32 10.37 634 283394 119927 42217380
Small intestinal obstruction 19.26 10.37 186 283842 16875 42320432
Osteonecrosis of jaw 19.12 10.37 64 283964 18985 42318322
Mite allergy 19.10 10.37 5 284023 5041 42332266
Withdrawal syndrome 19.03 10.37 44 283984 14731 42322576
Trisomy 18 18.93 10.37 26 284002 839 42336468
Intestinal stenosis 18.90 10.37 51 283977 2753 42334554
Ear infection 18.84 10.37 148 283880 12656 42324651
Graft versus host disease 18.73 10.37 36 283992 12889 42324418
Stevens-Johnson syndrome 18.70 10.37 80 283948 22098 42315209
Foetal disorder 18.63 10.37 29 283999 1050 42336257
Throat lesion 18.61 10.37 13 284015 176 42337131
Drug dose omission by device 18.51 10.37 8 284020 5878 42331429
Obsessive-compulsive disorder 18.46 10.37 11 284017 6732 42330575
Catarrh 18.45 10.37 84 283944 5902 42331405
Post procedural infection 18.44 10.37 82 283946 5703 42331604
Cardiac murmur 18.43 10.37 147 283881 12628 42324679
Lower respiratory tract infection 18.39 10.37 381 283647 40825 42296482
Cellulitis 18.35 10.37 539 283489 61046 42276261
Eosinophilia 18.31 10.37 136 283892 32763 42304544
Intervertebral disc degeneration 18.15 10.37 97 283931 7270 42330037
Dysstasia 18.15 10.37 158 283870 13928 42323379
Parosmia 18.10 10.37 100 283928 7591 42329716
Status epilepticus 18.03 10.37 49 283979 15529 42321778
Hypotonia neonatal 17.88 10.37 34 283994 1450 42335857
Kyphosis 17.71 10.37 32 283996 1312 42335995
Bronchopulmonary aspergillosis 17.69 10.37 68 283960 19361 42317946
Wrong technique in product usage process 17.69 10.37 190 283838 42445 42294862
Rebound effect 17.59 10.37 14 284014 7365 42329942
Sacroiliitis 17.53 10.37 40 283988 1942 42335365
Migraine 17.52 10.37 252 283776 25162 42312145
Injection site haemorrhage 17.46 10.37 136 283892 11600 42325707
Rhinitis 17.38 10.37 138 283890 11839 42325468
Systemic lupus erythematosus 17.33 10.37 114 283914 9210 42328097
Haemodynamic instability 17.32 10.37 36 283992 12521 42324786
Extrapyramidal disorder 17.26 10.37 54 283974 16358 42320949
C-reactive protein increased 17.26 10.37 550 283478 63010 42274297
Sexual dysfunction 17.25 10.37 12 284016 6763 42330544
Medical device implantation 17.25 10.37 21 284007 600 42336707
Gallbladder disorder 17.22 10.37 95 283933 7207 42330100
Diarrhoea 17.21 10.37 3400 280628 457449 41879858
Umbilical hernia 17.21 10.37 77 283951 5370 42331937
Selective eating disorder 17.18 10.37 37 283991 1727 42335580
Drug intolerance 17.15 10.37 677 283351 79747 42257560
Cholelithiasis 17.10 10.37 234 283794 23112 42314195
Temperature regulation disorder 17.09 10.37 29 283999 1130 42336177
Transient aphasia 17.03 10.37 21 284007 608 42336699
Thymus disorder 16.84 10.37 14 284014 249 42337058
Mean cell volume increased 16.83 10.37 61 283967 3862 42333445
Nephrotic syndrome 16.77 10.37 20 284008 8698 42328609
Skin injury 16.77 10.37 47 283981 2594 42334713
Lung opacity 16.73 10.37 9 284019 5828 42331479
Arthrodesis 16.71 10.37 20 284008 561 42336746
Hepatocellular injury 16.71 10.37 91 283937 23587 42313720
Hypertriglyceridaemia 16.69 10.37 26 284002 10100 42327207
Hepatic encephalopathy 16.67 10.37 55 283973 16387 42320920
Cytomegalovirus chorioretinitis 16.65 10.37 5 284023 4606 42332701
Hepatotoxicity 16.54 10.37 99 283929 25068 42312239
Motor developmental delay 16.52 10.37 22 284006 689 42336618
Radiation inflammation 16.50 10.37 27 284001 1021 42336286
Gingival pain 16.49 10.37 105 283923 8389 42328918
Disinhibition 16.48 10.37 3 284025 3892 42333415
Dyslexia 16.46 10.37 16 284012 352 42336955
Knee deformity 16.43 10.37 23 284005 756 42336551
Nocardiosis 16.41 10.37 7 284021 5183 42332124
Blood creatine phosphokinase increased 16.40 10.37 225 283803 48113 42289194
Therapeutic reaction time decreased 16.28 10.37 40 283988 2038 42335269
Burns second degree 16.22 10.37 82 283946 6014 42331293
Needle fatigue 16.13 10.37 29 283999 1184 42336123
Blood iron decreased 16.13 10.37 84 283944 6234 42331073
Ankyloglossia congenital 16.10 10.37 16 284012 362 42336945
Neoplasm progression 16.08 10.37 120 283908 28880 42308427
Cleft lip and palate 16.03 10.37 25 284003 907 42336400
Pseudocellulitis 15.95 10.37 14 284014 269 42337038
Tumour lysis syndrome 15.93 10.37 85 283943 22146 42315161
Dissociation 15.91 10.37 3 284025 3795 42333512
Ear disorder 15.85 10.37 39 283989 1989 42335318
Lacrimal disorder 15.85 10.37 15 284013 319 42336988
Congenital foot malformation 15.84 10.37 17 284011 422 42336885
Hypothyroidism 15.84 10.37 137 283891 31947 42305360
Skin abrasion 15.83 10.37 101 283927 8074 42329233
Miosis 15.78 10.37 42 283986 13404 42323903
Thrombocytopenia 15.73 10.37 1074 282954 189205 42148102
Complications of transplanted kidney 15.70 10.37 8 284020 5342 42331965
Endophthalmitis 15.66 10.37 5 284023 4428 42332879
Multiple congenital abnormalities 15.66 10.37 19 284009 541 42336766
Encephalopathy 15.65 10.37 188 283840 41145 42296162
Pseudomonas infection 15.64 10.37 54 283974 15869 42321438
Colorectal cancer 15.60 10.37 7 284021 5031 42332276
Tinea pedis 15.60 10.37 39 283989 2009 42335298
Product dose omission issue 15.50 10.37 1212 282816 153153 42184154
Low set ears 15.43 10.37 18 284010 491 42336816
Cerebral infarction 15.43 10.37 133 283895 31036 42306271
Gait spastic 15.42 10.37 31 283997 1378 42335929
Sleep disorder due to a general medical condition 15.31 10.37 62 283966 17391 42319916
Antineutrophil cytoplasmic antibody positive 15.29 10.37 5 284023 4360 42332947
Anaphylactic reaction 15.22 10.37 197 283831 42546 42294761
Hernia 15.21 10.37 126 283902 10947 42326360
Oropharyngeal pain 15.21 10.37 381 283647 42129 42295178
Hypervitaminosis D 15.21 10.37 7 284021 39 42337268
Torsade de pointes 15.20 10.37 21 284007 8573 42328734
Klebsiella infection 15.20 10.37 33 283995 11299 42326008
Hepatitis fulminant 15.18 10.37 7 284021 4952 42332355
Transfusion-related circulatory overload 15.18 10.37 22 284006 747 42336560
Squamous cell carcinoma of lung 15.17 10.37 41 283987 2215 42335092
Oxygen saturation decreased 15.10 10.37 550 283478 64137 42273170
Asphyxia 15.08 10.37 20 284008 8306 42329001
Movement disorder 15.03 10.37 157 283871 14541 42322766
Intellectual disability 15.00 10.37 37 283991 1890 42335417
Urticaria 14.98 10.37 377 283651 73659 42263648
Central nervous system mass 14.87 10.37 23 284005 828 42336479
Memory impairment 14.81 10.37 439 283589 49783 42287524
Wall motion score index abnormal 14.79 10.37 23 284005 832 42336475
Hip fracture 14.78 10.37 146 283882 13326 42323981
Intestinal resection 14.73 10.37 36 283992 1828 42335479
Accessory spleen 14.65 10.37 10 284018 130 42337177
Saliva altered 14.65 10.37 12 284016 209 42337098
Infection 14.59 10.37 899 283129 111169 42226138
Malignant melanoma 14.58 10.37 110 283918 9290 42328017
Spina bifida 14.57 10.37 16 284012 408 42336899
Hepatitis cholestatic 14.56 10.37 27 284001 9797 42327510
Hypophosphataemia 14.51 10.37 81 283947 20864 42316443
Serum ferritin increased 14.48 10.37 90 283938 7129 42330178
Lung neoplasm malignant 14.47 10.37 193 283835 18954 42318353
Hypocalcaemia 14.38 10.37 130 283898 30043 42307264
Osteopenia 14.35 10.37 81 283947 6197 42331110
Central nervous system inflammation 14.27 10.37 12 284016 217 42337090
Loss of consciousness 14.24 10.37 488 283540 91866 42245441
Intentional product use issue 14.24 10.37 600 283428 71233 42266074
Candida infection 14.20 10.37 85 283943 21525 42315782
Cleft lip 14.19 10.37 14 284014 314 42336993
Hyperammonaemia 14.14 10.37 19 284009 7847 42329460
Cardiac septal defect 14.13 10.37 24 284004 936 42336371
Limb reduction defect 14.04 10.37 14 284014 318 42336989
Therapeutic product effect decreased 14.04 10.37 351 283677 38799 42298508
Synovial cyst 14.04 10.37 44 283984 2585 42334722
Loss of personal independence in daily activities 14.03 10.37 433 283595 49383 42287924
Congenital bladder anomaly 14.02 10.37 13 284015 269 42337038
Haemophagocytic lymphohistiocytosis 14.01 10.37 68 283960 18154 42319153
Anaemia vitamin B12 deficiency 13.98 10.37 18 284010 545 42336762
Airway remodelling 13.91 10.37 23 284005 877 42336430
Mania 13.91 10.37 31 283997 10516 42326791
Pulmonary haemorrhage 13.84 10.37 35 283993 11362 42325945
Blood uric acid increased 13.78 10.37 55 283973 15492 42321815
Amyloid related imaging abnormality-oedema/effusion 13.74 10.37 20 284008 682 42336625
Weight decrease neonatal 13.73 10.37 14 284014 327 42336980
Urine odour abnormal 13.73 10.37 32 283996 1576 42335731
Pectus excavatum 13.70 10.37 12 284016 230 42337077
Fistula 13.66 10.37 95 283933 7817 42329490
Inguinal hernia 13.66 10.37 104 283924 8808 42328499
Second primary malignancy 13.59 10.37 27 284001 9548 42327759
Graft versus host disease in skin 13.58 10.37 9 284019 5203 42332104
Progressive multifocal leukoencephalopathy 13.57 10.37 36 283992 11500 42325807
Congenital anomaly 13.52 10.37 31 283997 1510 42335797
Dystonia 13.51 10.37 42 283986 12748 42324559
Renal aplasia 13.46 10.37 21 284007 762 42336545
Diabetes insipidus 13.46 10.37 4 284024 3709 42333598
Tuberculosis 13.39 10.37 114 283914 9985 42327322
Kidney infection 13.33 10.37 84 283944 6686 42330621
Fibula fracture 13.33 10.37 26 284002 1130 42336177
Red blood cell sedimentation rate 13.33 10.37 25 284003 1055 42336252
Polydactyly 13.32 10.37 27 284001 1207 42336100
Crohn's disease 13.31 10.37 47 283981 2937 42334370
Acute generalised exanthematous pustulosis 13.29 10.37 23 284005 8572 42328735
Diverticulum 13.29 10.37 91 283937 7450 42329857
Septic arthritis staphylococcal 13.27 10.37 17 284011 512 42336795
Increased tendency to bruise 13.23 10.37 61 283967 4309 42332998
Normochromic normocytic anaemia 13.22 10.37 25 284003 9006 42328301
Dry throat 13.20 10.37 46 283982 2856 42334451
End stage renal disease 13.19 10.37 61 283967 16497 42320810
Hand fracture 13.16 10.37 46 283982 2860 42334447
Otitis media 13.13 10.37 54 283974 3629 42333678
Hypersomnia 13.05 10.37 152 283876 14466 42322841
Disability assessment scale score increased 13.04 10.37 15 284013 403 42336904
Relapsing-remitting multiple sclerosis 13.03 10.37 30 283998 1465 42335842
Pulmonary pain 13.03 10.37 31 283997 1547 42335760
Acute graft versus host disease in intestine 13.02 10.37 5 284023 3946 42333361
Arthritis bacterial 12.95 10.37 75 283953 5793 42331514
Device leakage 12.95 10.37 31 283997 10254 42327053
Fistula discharge 12.87 10.37 25 284003 1083 42336224
Generalised tonic-clonic seizure 12.86 10.37 113 283915 26266 42311041
Joint ankylosis 12.84 10.37 32 283996 1645 42335662
Polyhydramnios 12.84 10.37 12 284016 251 42337056
Venoocclusive disease 12.83 10.37 5 284023 3910 42333397
Blood insulin increased 12.81 10.37 14 284014 355 42336952
Blood test abnormal 12.79 10.37 137 283891 12769 42324538
Liver injury 12.75 10.37 75 283953 19073 42318234
Pernicious anaemia 12.75 10.37 9 284019 124 42337183
Mouth ulceration 12.66 10.37 154 283874 14809 42322498
Hypertelorism 12.65 10.37 18 284010 601 42336706
Bursitis 12.63 10.37 78 283950 6166 42331141
Hepatic steatosis 12.60 10.37 207 283821 21241 42316066
Hypothermia 12.59 10.37 42 283986 12473 42324834
Glycosylated haemoglobin increased 12.58 10.37 44 283984 12880 42324427
Atopy 12.57 10.37 23 284005 952 42336355
Hyperpyrexia 12.49 10.37 4 284024 3536 42333771
Antipsychotic drug level below therapeutic 12.46 10.37 3 284025 3201 42334106
Gait apraxia 12.45 10.37 4 284024 6 42337301
Bronchitis 12.44 10.37 407 283621 46794 42290513
Limb injury 12.44 10.37 148 283880 14157 42323150
Peripheral coldness 12.43 10.37 97 283931 8278 42329029
Disease recurrence 12.41 10.37 132 283896 29546 42307761
Vitamin B complex deficiency 12.39 10.37 16 284012 486 42336821
Ligament rupture 12.37 10.37 28 284000 1352 42335955
Abscess intestinal 12.32 10.37 33 283995 1773 42335534
Scrotal infection 12.31 10.37 21 284007 822 42336485
Strabismus 12.27 10.37 39 283989 2309 42334998
Gastrointestinal infection 12.26 10.37 82 283946 6661 42330646
Shock haemorrhagic 12.26 10.37 61 283967 16181 42321126
Cyst 12.24 10.37 69 283959 5277 42332030
Attention deficit hyperactivity disorder 12.23 10.37 47 283981 3061 42334246
Blood parathyroid hormone decreased 12.21 10.37 31 283997 1612 42335695
Rheumatoid lung 12.17 10.37 22 284006 902 42336405
Laboratory test abnormal 12.14 10.37 218 283810 22760 42314547
Oesophageal fibrosis 12.12 10.37 10 284018 176 42337131
Central cord syndrome 12.05 10.37 3 284025 0 42337307
Heat oedema 12.05 10.37 3 284025 0 42337307
Cardiac failure chronic 12.04 10.37 29 283999 9572 42327735
Vein disorder 11.99 10.37 36 283992 2066 42335241
Euglycaemic diabetic ketoacidosis 11.98 10.37 12 284016 5648 42331659
Cholestasis 11.90 10.37 151 283877 32728 42304579
Strongyloidiasis 11.89 10.37 4 284024 3427 42333880
Sepsis 11.89 10.37 1155 282873 198179 42139128
Tooth malformation 11.89 10.37 10 284018 181 42337126
Granuloma skin 11.85 10.37 25 284003 1150 42336157
Blister infected 11.85 10.37 16 284012 508 42336799
Pancreatitis acute 11.83 10.37 155 283873 33409 42303898
Unresponsive to stimuli 11.83 10.37 143 283885 31260 42306047
Hydrocele 11.80 10.37 41 283987 2542 42334765
Abortion spontaneous 11.77 10.37 14 284014 390 42336917
Blood magnesium decreased 11.75 10.37 90 283938 7636 42329671
On and off phenomenon 11.71 10.37 50 283978 3417 42333890
Rib fracture 11.69 10.37 165 283863 16406 42320901
Hypotension 11.69 10.37 1521 282507 256110 42081197
Acoustic neuroma 11.67 10.37 9 284019 143 42337164
Carcinoid tumour of the small bowel 11.64 10.37 14 284014 395 42336912
Chest expansion decreased 11.62 10.37 9 284019 144 42337163
Anti-erythropoietin antibody positive 11.62 10.37 21 284007 861 42336446
Hernia pain 11.61 10.37 12 284016 285 42337022
Cardiac flutter 11.60 10.37 36 283992 2104 42335203
Fear 11.59 10.37 36 283992 10929 42326378
Hypoalbuminaemia 11.57 10.37 59 283969 15551 42321756
Interstitial lung disease 11.55 10.37 417 283611 78045 42259262
Muscle twitching 11.54 10.37 40 283988 11740 42325567
Hyperphosphataemia 11.53 10.37 46 283982 12958 42324349
Hyperlactacidaemia 11.50 10.37 8 284020 4508 42332799
Restlessness 11.47 10.37 132 283896 29117 42308190
Irritability 11.40 10.37 126 283902 28002 42309305
Respiratory distress 11.37 10.37 203 283825 41617 42295690
Pleural fibrosis 11.35 10.37 27 284001 1347 42335960
Inappropriate schedule of product administration 11.33 10.37 763 283265 95139 42242168
Catatonia 11.29 10.37 15 284013 6224 42331083
Hepatitis B 11.28 10.37 17 284011 6694 42330613
Scoliosis 11.27 10.37 46 283982 3080 42334227
Vascular insufficiency 11.22 10.37 13 284015 352 42336955
Hip arthroplasty 11.19 10.37 67 283961 5238 42332069
Anti-cyclic citrullinated peptide antibody positive 11.15 10.37 33 283995 1879 42335428
Immunodeficiency 11.13 10.37 85 283943 7205 42330102
Osteomyelitis 11.13 10.37 177 283851 18046 42319261
Product packaging difficult to open 11.13 10.37 4 284024 10 42337297
Pharyngeal disorder 11.12 10.37 21 284007 891 42336416
Folate deficiency 11.09 10.37 31 283997 1708 42335599
Spondyloarthropathy 11.08 10.37 21 284007 893 42336414
Abdominal adhesions 11.06 10.37 31 283997 1711 42335596
Flatulence 11.04 10.37 232 283796 24920 42312387
Fracture 11.02 10.37 92 283936 8011 42329296
Accidental exposure to product 11.02 10.37 85 283943 20308 42316999
Micturition disorder 11.01 10.37 39 283989 2441 42334866
Hypopnoea 10.99 10.37 90 283938 7792 42329515
Neutropenia neonatal 10.99 10.37 21 284007 899 42336408
Blood potassium decreased 10.98 10.37 194 283834 20190 42317117
Dizziness 10.98 10.37 1855 282173 247399 42089908
Epstein-Barr virus infection 10.93 10.37 31 283997 9687 42327620
Enterocolitis 10.92 10.37 32 283996 9897 42327410
Autoscopy 10.92 10.37 11 284017 253 42337054
Tachypnoea 10.92 10.37 92 283936 21570 42315737
Gangrene neonatal 10.86 10.37 10 284018 205 42337102
Dermatitis acneiform 10.83 10.37 22 284006 7717 42329590
Cystitis bacterial 10.82 10.37 10 284018 206 42337101
Diabetic ketoacidosis 10.82 10.37 96 283932 22271 42315036
Hepatitis E antibody positive 10.82 10.37 11 284017 256 42337051
Immunosuppressant drug level increased 10.80 10.37 22 284006 7709 42329598
Coagulopathy 10.78 10.37 95 283933 22067 42315240
Drug eruption 10.75 10.37 100 283928 22975 42314332
Faecal calprotectin increased 10.74 10.37 45 283983 3049 42334258
Anuria 10.73 10.37 40 283988 11492 42325815
Adverse drug reaction 10.71 10.37 326 283702 37108 42300199
Hypertransaminasaemia 10.70 10.37 29 283999 9198 42328109
Cryptococcosis 10.69 10.37 4 284024 3207 42334100
Respiratory acidosis 10.68 10.37 16 284012 6315 42330992
C-reactive protein decreased 10.66 10.37 36 283992 2200 42335107
Dehiscence 10.65 10.37 17 284011 629 42336678
Gastrointestinal anastomotic stenosis 10.65 10.37 6 284022 54 42337253
Adrenal insufficiency 10.64 10.37 78 283950 18846 42318461
Coccydynia 10.63 10.37 17 284011 630 42336677
Fine motor skill dysfunction 10.63 10.37 36 283992 2203 42335104
Cerebral microangiopathy 10.63 10.37 10 284018 211 42337096
Nerve compression 10.59 10.37 54 283974 3974 42333333
Diabetes mellitus 10.59 10.37 312 283716 59775 42277532
Arnold-Chiari malformation 10.58 10.37 13 284015 375 42336932
Hepatitis acute 10.56 10.37 28 284000 8947 42328360
Hallucination, auditory 10.56 10.37 57 283971 14807 42322500
Tinnitus 10.54 10.37 260 283768 28678 42308629
Renal injury 10.53 10.37 44 283984 12236 42325071
Maternal exposure timing unspecified 10.53 10.37 13 284015 377 42336930
Transplant failure 10.51 10.37 7 284021 4037 42333270
Hypermetropia 10.44 10.37 15 284013 505 42336802
Cardiac failure acute 10.41 10.37 51 283977 13582 42323725
Haemangioma 10.40 10.37 33 283995 1952 42335355
Macrocytosis 10.39 10.37 23 284005 1094 42336213
Benign abdominal neoplasm 10.39 10.37 7 284021 89 42337218
Erythema multiforme 10.37 10.37 33 283995 9944 42327363

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 1476.57 10.41 1248 976544 479307 109132200
Completed suicide 1468.28 10.41 201 977591 242180 109369327
Drug abuse 1024.07 10.41 169 977623 177242 109434265
Drug interaction 926.46 10.41 1893 975899 498290 109113217
Arthropathy 783.57 10.41 4781 973011 282741 109328766
Systemic lupus erythematosus 768.49 10.41 4346 973446 249992 109361515
Pemphigus 724.10 10.41 3779 974013 210791 109400716
Synovitis 717.51 10.41 4511 973281 269581 109341926
Joint swelling 700.84 10.41 6475 971317 436370 109175137
Rheumatoid arthritis 700.43 10.41 4793 972999 294820 109316687
Hand deformity 699.58 10.41 3793 973999 214713 109396794
Glossodynia 649.21 10.41 3761 974031 218243 109393264
Arthralgia 645.94 10.41 10072 967720 769560 108841947
Intentional overdose 609.68 10.41 205 977587 132296 109479211
Abdominal discomfort 555.04 10.41 5621 972171 388237 109223270
Anti-cyclic citrullinated peptide antibody positive 540.42 10.41 3096 974696 178888 109432619
Wound 538.55 10.41 3735 974057 230702 109380805
Pericarditis 499.80 10.41 3485 974307 215629 109395878
Alopecia 497.33 10.41 5171 972621 359582 109251925
Pain 492.59 10.41 11472 966320 943483 108668024
Acute kidney injury 469.40 10.41 3489 974303 631941 108979566
Maternal exposure during pregnancy 464.08 10.41 3845 973947 251038 109360469
Infusion related reaction 454.07 10.41 5261 972531 375901 109235606
Nasopharyngitis 453.80 10.41 5407 972385 388954 109222553
Duodenal ulcer perforation 448.24 10.41 2898 974894 174802 109436705
Helicobacter infection 435.05 10.41 2927 974865 178950 109432557
Swelling 426.02 10.41 4863 972929 346178 109265329
Febrile neutropenia 424.75 10.41 1409 976383 315358 109296149
Psoriatic arthropathy 421.69 10.41 3083 974709 193678 109417829
Therapeutic product effect decreased 387.21 10.41 3575 974217 240741 109370766
Discomfort 380.14 10.41 3219 974573 211488 109400019
Cardiac arrest 372.76 10.41 734 977058 196019 109415488
Rheumatoid factor positive 368.33 10.41 2205 975587 129435 109482072
Musculoskeletal stiffness 356.46 10.41 3914 973878 275908 109335599
Overdose 356.30 10.41 980 976812 232814 109378693
Suicide attempt 336.39 10.41 253 977539 103141 109508366
Depressed level of consciousness 330.39 10.41 303 977489 111975 109499532
Multiple organ dysfunction syndrome 327.06 10.41 522 977270 151188 109460319
Death 326.69 10.41 4287 973505 694582 108916925
Impaired healing 316.43 10.41 2888 974904 193829 109417678
Disease progression 308.45 10.41 1113 976679 242921 109368586
Sinusitis 307.54 10.41 3990 973802 292698 109318809
Contraindicated product administered 291.46 10.41 3418 974374 244849 109366658
Hepatic enzyme increased 288.82 10.41 4208 973584 316684 109294823
Drug reaction with eosinophilia and systemic symptoms 286.75 10.41 186 977606 81909 109529598
Peripheral swelling 285.32 10.41 5089 972703 398945 109212562
Myelosuppression 281.86 10.41 251 977541 94089 109517418
Rhabdomyolysis 281.15 10.41 392 977400 120009 109491498
Coma 279.01 10.41 380 977412 117489 109494018
Fatigue 278.55 10.41 13274 964518 1202684 108408823
Fibromyalgia 274.27 10.41 2508 975284 168401 109443106
Malignant neoplasm progression 274.02 10.41 721 977071 173846 109437661
Sedation 265.83 10.41 142 977650 69541 109541966
Serotonin syndrome 264.36 10.41 96 977696 59057 109552450
Respiratory failure 263.00 10.41 996 976796 214336 109397171
Hepatic function abnormal 261.51 10.41 242 977550 89053 109522454
Electrocardiogram QT prolonged 260.21 10.41 349 977443 108611 109502896
Drug resistance 257.92 10.41 88 977704 56286 109555221
Irritable bowel syndrome 255.56 10.41 2394 975398 161821 109449686
C-reactive protein abnormal 253.48 10.41 1989 975803 127706 109483801
Neutropenia 251.51 10.41 2110 975682 372510 109238997
Folliculitis 250.43 10.41 2423 975369 165230 109446277
Blister 248.78 10.41 3089 974703 224287 109387220
Lower respiratory tract infection 245.42 10.41 3254 974538 239852 109371655
Muscle injury 240.67 10.41 2095 975697 138712 109472795
Lactic acidosis 239.68 10.41 280 977512 92531 109518976
Hyponatraemia 235.66 10.41 1055 976737 216598 109394909
Osteoarthritis 234.50 10.41 2559 975233 180064 109431443
Arthritis 231.42 10.41 2383 975409 165203 109446304
Bradycardia 230.12 10.41 661 977131 154856 109456651
Weight increased 228.01 10.41 5082 972710 414562 109196945
Sleep disorder due to general medical condition, insomnia type 226.01 10.41 1655 976137 103988 109507519
Cardiac failure 219.41 10.41 883 976909 186743 109424764
Hypotension 216.29 10.41 3293 974499 520556 109090951
Renal failure 215.94 10.41 1149 976643 225425 109386082
Contusion 214.95 10.41 3073 974719 230288 109381219
Drug ineffective for unapproved indication 214.02 10.41 362 977430 102476 109509031
Rheumatic fever 208.02 10.41 1821 975971 120758 109490749
Renal impairment 200.06 10.41 920 976872 187525 109423982
Cardio-respiratory arrest 196.95 10.41 459 977333 115377 109496130
Blood pressure fluctuation 192.67 10.41 1227 976565 73597 109537910
Drug intolerance 191.76 10.41 4828 972964 401684 109209823
Respiratory arrest 190.46 10.41 142 977650 58157 109553350
Cytomegalovirus infection 189.25 10.41 124 977668 54320 109557187
Sopor 187.49 10.41 46 977746 36500 109575007
Angioedema 186.88 10.41 367 977425 98133 109513374
Exposure during pregnancy 185.86 10.41 2281 975511 165143 109446364
Hepatic failure 182.24 10.41 203 977589 68536 109542971
Ill-defined disorder 181.55 10.41 2154 975638 154699 109456808
Cytokine release syndrome 180.58 10.41 213 977579 70093 109541414
Thrombocytopenia 179.26 10.41 2096 975696 346789 109264718
Hypoglycaemia 175.06 10.41 489 977303 115615 109495892
Inflammation 174.88 10.41 2537 975255 190701 109420806
Agitation 171.30 10.41 475 977317 112576 109498931
Sickle cell anaemia with crisis 171.29 10.41 305 977487 9240 109602267
Altered state of consciousness 168.93 10.41 156 977636 57470 109554037
Stomatitis 168.20 10.41 3339 974453 266903 109344604
Off label use 165.75 10.41 11236 966556 1488949 108122558
Tachycardia 165.21 10.41 1248 976544 225397 109386110
Swollen joint count increased 163.97 10.41 1284 976508 82377 109529130
Intentional product misuse 162.70 10.41 614 977178 132290 109479217
Metabolic acidosis 161.07 10.41 406 977386 99338 109512169
Somnolence 159.04 10.41 1771 976021 295678 109315829
Product use in unapproved indication 158.75 10.41 2891 974901 444486 109167021
Hypersensitivity 157.85 10.41 4683 973109 399315 109212192
Blood pressure systolic increased 156.24 10.41 1262 976530 81729 109529778
Type 2 diabetes mellitus 154.53 10.41 2312 975480 174920 109436587
Intentional product use issue 153.91 10.41 3062 974730 244844 109366663
Sepsis 152.20 10.41 2009 975783 325337 109286170
Red blood cell sedimentation rate abnormal 151.91 10.41 520 977272 23989 109587518
Respiratory depression 151.60 10.41 47 977745 31954 109579553
Ventricular fibrillation 147.84 10.41 91 977701 41222 109570285
Pain in extremity 146.45 10.41 5475 972317 481643 109129864
Anaphylactic shock 145.89 10.41 144 977648 51402 109560105
Knee arthroplasty 145.55 10.41 1029 976763 63919 109547588
Drug dependence 142.43 10.41 139 977653 49881 109561626
Shock 141.25 10.41 159 977633 53429 109558078
Blood pressure systolic abnormal 140.06 10.41 511 977281 24339 109587168
Joint range of motion decreased 136.98 10.41 1664 976128 120168 109491339
Hyperkalaemia 134.77 10.41 679 977113 135117 109476390
Cardiogenic shock 132.52 10.41 188 977604 57150 109554357
Hyperglycaemia 132.30 10.41 353 977439 84737 109526770
Psoriasis 131.83 10.41 1851 975941 138142 109473365
Ascites 131.82 10.41 402 977390 92406 109519101
Seizure 131.65 10.41 1284 976508 219901 109391606
Facet joint syndrome 131.31 10.41 1372 976420 95456 109516051
Product use issue 128.82 10.41 3639 974153 308056 109303451
Hip arthroplasty 127.84 10.41 889 976903 54924 109556583
Grip strength decreased 127.77 10.41 1175 976617 78999 109532508
Hyperhidrosis 127.35 10.41 1051 976741 186247 109425260
Hypoxia 126.03 10.41 652 977140 128863 109482644
Ventricular tachycardia 125.78 10.41 154 977638 49855 109561652
Blood pressure diastolic abnormal 125.12 10.41 506 977286 25309 109586198
Poisoning 123.81 10.41 51 977741 29054 109582453
Lip dry 121.38 10.41 1387 976405 98696 109512811
Pregnancy 120.28 10.41 819 976973 50248 109561259
Acute hepatic failure 120.19 10.41 88 977704 36380 109575127
Constipation 119.77 10.41 2335 975457 355451 109256056
Hepatocellular injury 119.08 10.41 164 977628 50478 109561029
Sedation complication 118.87 10.41 17 977775 19838 109591669
Blood cholesterol increased 118.58 10.41 2294 975498 182491 109429016
Musculoskeletal pain 118.43 10.41 2275 975517 180748 109430759
Neurotoxicity 118.20 10.41 119 977673 42088 109569419
Disseminated intravascular coagulation 117.24 10.41 115 977677 41171 109570336
Hypoaesthesia 117.19 10.41 3622 974170 310601 109300906
Heart rate decreased 115.72 10.41 1180 976612 81576 109529931
Leukopenia 115.30 10.41 805 976987 147986 109463521
Aspergillus infection 113.73 10.41 42 977750 25574 109585933
Intentional self-injury 113.70 10.41 98 977694 37331 109574176
Mobility decreased 113.06 10.41 2824 974968 234598 109376909
Mydriasis 111.52 10.41 29 977763 22128 109589379
Gastrointestinal disorder 110.25 10.41 2861 974931 239091 109372416
Suspected suicide 109.74 10.41 6 977786 15193 109596314
Infection 107.33 10.41 4065 973727 358135 109253372
Anaemia 107.05 10.41 3858 973934 543228 109068279
Red blood cell sedimentation rate increased 106.88 10.41 1111 976681 77191 109534316
Appendicolith 104.91 10.41 5 977787 14250 109597257
Thrombotic microangiopathy 104.59 10.41 64 977728 29085 109582422
Cholestasis 102.32 10.41 265 977527 64253 109547254
Therapy partial responder 102.07 10.41 106 977686 36955 109574552
Proteinuria 101.95 10.41 122 977670 39896 109571611
Post transplant lymphoproliferative disorder 101.80 10.41 10 977782 15603 109595904
Treatment failure 101.60 10.41 3189 974603 274045 109337462
Neuroleptic malignant syndrome 101.26 10.41 91 977701 33968 109577539
Encephalopathy 100.80 10.41 372 977420 80683 109530824
Drug use disorder 100.35 10.41 19 977773 18055 109593452
Suicidal ideation 100.01 10.41 458 977334 93479 109518028
Abortion spontaneous 99.53 10.41 580 977212 33702 109577805
Blood pressure increased 98.92 10.41 2988 974804 255385 109356122
Neoplasm progression 98.89 10.41 270 977522 64325 109547182
Palmar-plantar erythrodysaesthesia syndrome 96.32 10.41 133 977659 40892 109570615
Blood creatine phosphokinase increased 95.80 10.41 328 977464 72749 109538758
Posterior reversible encephalopathy syndrome 95.36 10.41 95 977697 33766 109577741
Anaphylactic reaction 95.28 10.41 605 977187 113695 109497812
Pulmonary alveolar haemorrhage 94.73 10.41 30 977762 20120 109591387
Torsade de pointes 93.90 10.41 41 977751 22559 109588948
Joint effusion 93.66 10.41 400 977392 20505 109591002
Venoocclusive liver disease 93.47 10.41 12 977780 15195 109596312
Injury 93.35 10.41 2138 975654 175127 109436380
Temperature regulation disorder 92.80 10.41 5 977787 12821 109598686
Live birth 90.67 10.41 977 976815 68507 109543000
Cytomegalovirus infection reactivation 90.37 10.41 25 977767 18308 109593199
Bronchopulmonary aspergillosis 89.73 10.41 79 977713 29784 109581723
Status epilepticus 89.57 10.41 88 977704 31483 109580024
Enthesopathy 89.26 10.41 278 977514 12200 109599307
Pathogen resistance 89.19 10.41 23 977769 17649 109593858
Cerebral haemorrhage 88.32 10.41 287 977505 64681 109546826
Gamma-glutamyltransferase increased 88.18 10.41 264 977528 61045 109550462
Disability assessment scale score increased 87.88 10.41 145 977647 4125 109607382
Acute respiratory distress syndrome 87.86 10.41 214 977578 52984 109558523
Hypokalaemia 87.21 10.41 1113 976679 181335 109430172
Miosis 86.51 10.41 43 977749 21940 109589567
BK virus infection 86.50 10.41 8 977784 13098 109598409
Septic shock 86.09 10.41 933 976859 156595 109454912
Exposure to toxic agent 84.46 10.41 8 977784 12850 109598657
C-reactive protein increased 84.16 10.41 2523 975269 215396 109396111
Ejection fraction decreased 84.03 10.41 145 977647 40735 109570772
Respiratory distress 83.75 10.41 319 977473 68555 109542952
Sciatica 83.49 10.41 1213 976579 91186 109520321
Bursitis 82.35 10.41 1610 976182 128308 109483199
Aggression 82.28 10.41 259 977533 58951 109552556
Deep vein thrombosis postoperative 81.74 10.41 843 976949 58448 109553059
Hepatotoxicity 81.47 10.41 287 977505 63113 109548394
Haemoptysis 81.37 10.41 339 977453 71015 109540492
Blood pressure diastolic decreased 81.25 10.41 570 977222 35315 109576192
Wound infection 81.18 10.41 1251 976541 95214 109516293
Drug level increased 81.17 10.41 189 977603 47530 109563977
Hypothermia 80.95 10.41 68 977724 26234 109585273
Neutrophil count decreased 80.67 10.41 682 977110 120259 109491248
Cerebral infarction 80.62 10.41 215 977577 51623 109559884
Transplant rejection 80.03 10.41 60 977732 24507 109587000
Interstitial lung disease 79.89 10.41 816 976976 138518 109472989
Loss of personal independence in daily activities 79.79 10.41 1812 975980 148208 109463299
Toxic epidermal necrolysis 79.64 10.41 247 977545 56480 109555027
Creatinine renal clearance decreased 79.53 10.41 47 977745 21768 109589739
No adverse event 79.21 10.41 359 977433 73480 109538027
Obesity 78.15 10.41 1423 976369 111928 109499579
Joint stiffness 78.01 10.41 924 976868 66319 109545188
Acute graft versus host disease 77.18 10.41 11 977781 12870 109598637
Myocardial infarction 76.55 10.41 1215 976577 190868 109420639
Psychotic disorder 76.42 10.41 215 977577 50722 109560785
Drug withdrawal syndrome 76.39 10.41 137 977655 37917 109573590
Substance abuse 76.20 10.41 10 977782 12453 109599054
Akathisia 76.08 10.41 28 977764 17085 109594422
Haematotoxicity 76.04 10.41 46 977746 21036 109590471
Brain oedema 75.87 10.41 98 977694 31000 109580507
Haemophagocytic lymphohistiocytosis 75.41 10.41 101 977691 31458 109580049
Carpal tunnel syndrome 73.93 10.41 395 977397 22215 109589292
Graft versus host disease 73.68 10.41 37 977755 18769 109592738
Extrapyramidal disorder 73.54 10.41 88 977704 28779 109582728
Myoclonus 73.50 10.41 111 977681 32887 109578620
Agranulocytosis 73.20 10.41 289 977503 61471 109550036
Coagulopathy 72.87 10.41 158 977634 40753 109570754
Peripheral venous disease 72.76 10.41 1096 976696 83021 109528486
Road traffic accident 72.55 10.41 1344 976448 106054 109505453
Orthostatic hypotension 72.32 10.41 320 977472 65929 109545578
Syncope 71.98 10.41 1308 976484 201228 109410279
Breast cancer stage III 70.84 10.41 1037 976755 78080 109533427
Asphyxia 70.79 10.41 19 977773 14196 109597311
Forced expiratory volume decreased 70.76 10.41 15 977777 13161 109598346
Disturbance in attention 70.40 10.41 295 977497 61700 109549807
Body temperature decreased 70.23 10.41 563 977229 36372 109575135
Pancreatitis acute 70.20 10.41 284 977508 59990 109551517
Tumour lysis syndrome 70.18 10.41 102 977690 30699 109580808
Autoimmune disorder 69.55 10.41 885 976907 64598 109546909
Blood creatinine increased 69.19 10.41 1168 976624 181721 109429786
Unresponsive to stimuli 69.11 10.41 309 977483 63481 109548026
Rash 68.84 10.41 8277 969515 812687 108798820
Mucormycosis 68.79 10.41 7 977785 10621 109600886
Injection site reaction 68.52 10.41 1138 976654 87932 109523575
Cytomegalovirus viraemia 68.04 10.41 36 977756 17728 109593779
Adverse event 67.81 10.41 1345 976447 107464 109504043
Wrong technique in product usage process 66.96 10.41 474 977318 86874 109524633
Cardiac failure congestive 66.76 10.41 936 976856 150064 109461443
Stevens-Johnson syndrome 66.70 10.41 203 977589 46698 109564809
Graft versus host disease in gastrointestinal tract 66.47 10.41 3 977789 8965 109602542
Tachypnoea 66.23 10.41 157 977635 39238 109572269
Weight decreased 65.76 10.41 4896 972896 463161 109148346
Gait inability 65.74 10.41 1625 976167 134751 109476756
Condition aggravated 65.10 10.41 7435 970357 727401 108884106
Foot deformity 64.33 10.41 684 977108 47796 109563711
Pulmonary fibrosis 64.14 10.41 1263 976529 100779 109510728
Localised infection 63.16 10.41 620 977172 42428 109569079
Joint destruction 62.49 10.41 226 977566 10717 109600790
Polyarthritis 62.49 10.41 332 977460 18631 109592876
Acute graft versus host disease in skin 62.45 10.41 10 977782 10730 109600777
Bone erosion 62.36 10.41 656 977136 45715 109565792
Osteoporosis 62.16 10.41 1100 976692 86052 109525455
Gait disturbance 62.08 10.41 3032 974760 275176 109336331
Rash maculo-papular 61.78 10.41 393 977399 73829 109537678
Cognitive disorder 61.78 10.41 486 977306 87025 109524482
Rheumatoid nodule 61.29 10.41 347 977445 19949 109591558
Osteonecrosis of jaw 61.27 10.41 218 977574 47799 109563708
Dystonia 61.24 10.41 83 977709 25722 109585785
Lower limb fracture 60.68 10.41 970 976822 74378 109537129
Liver injury 60.66 10.41 1751 976041 148662 109462845
Ejection fraction 60.35 10.41 100 977692 2855 109608652
Blood bilirubin increased 60.34 10.41 408 977384 75564 109535943
Adenovirus infection 60.11 10.41 12 977780 10982 109600525
Polyomavirus-associated nephropathy 59.96 10.41 3 977789 8198 109603309
Acute generalised exanthematous pustulosis 59.62 10.41 62 977730 21602 109589905
Restlessness 59.46 10.41 275 977517 55984 109555523
Adjustment disorder with depressed mood 59.10 10.41 621 977171 43262 109568245
Immune reconstitution inflammatory syndrome 59.10 10.41 35 977757 16191 109595316
Pleural effusion 59.03 10.41 1161 976631 176548 109434959
Juvenile idiopathic arthritis 58.85 10.41 150 977642 5857 109605650
Sinus tachycardia 58.11 10.41 200 977592 44293 109567214
Atrial fibrillation 58.07 10.41 1565 976227 228077 109383430
Dry mouth 57.96 10.41 2239 975553 197709 109413798
Diabetic ketoacidosis 57.72 10.41 185 977607 41873 109569634
Pseudomonas infection 57.06 10.41 99 977693 27754 109583753
Hyperbilirubinaemia 56.69 10.41 116 977676 30555 109580952
Multiple-drug resistance 56.61 10.41 23 977769 13212 109598295
Sensitisation 56.51 10.41 118 977674 4033 109607474
Pyrexia 56.42 10.41 7018 970774 891247 108720260
Oropharyngeal pain 56.27 10.41 1581 976211 133695 109477812
Withdrawal syndrome 56.05 10.41 121 977671 31259 109580248
Polycystic ovaries 55.82 10.41 128 977664 4668 109606839
Basal cell carcinoma 55.61 10.41 629 977163 44641 109566866
Disorientation 54.90 10.41 382 977410 70289 109541218
Appendicitis 54.89 10.41 105 977687 28359 109583148
Metastases to liver 54.85 10.41 147 977645 35239 109576268
Mania 54.48 10.41 62 977730 20734 109590773
Toxic skin eruption 54.39 10.41 100 977692 27415 109584092
Blood pressure diastolic increased 53.83 10.41 317 977475 18490 109593017
Inappropriate antidiuretic hormone secretion 53.70 10.41 139 977653 33712 109577795
Bronchospasm 53.68 10.41 117 977675 30122 109581385
Psychomotor hyperactivity 53.61 10.41 60 977732 20217 109591290
Myalgia 53.28 10.41 1527 976265 220854 109390653
Caesarean section 52.64 10.41 252 977540 13565 109597942
Metastases to central nervous system 52.54 10.41 75 977717 22742 109588765
Generalised tonic-clonic seizure 52.21 10.41 277 977515 54403 109557104
Dislocation of vertebra 52.14 10.41 604 977188 43117 109568390
Arrhythmia 52.14 10.41 380 977412 69195 109542312
Electrocardiogram QRS complex prolonged 51.95 10.41 25 977767 12996 109598511
Night sweats 51.92 10.41 1552 976240 132431 109479076
Melaena 51.78 10.41 375 977417 68382 109543125
Epstein-Barr virus infection 51.15 10.41 54 977738 18684 109592823
Blood glucose increased 50.81 10.41 844 976948 131652 109479855
Disease recurrence 50.51 10.41 322 977470 60462 109551045
Mucosal inflammation 50.31 10.41 575 977217 95566 109515941
Hyperthermia 49.90 10.41 69 977723 21203 109590304
Rebound effect 49.74 10.41 35 977757 14771 109596736
Face oedema 49.67 10.41 142 977650 33327 109578180
Loss of consciousness 49.32 10.41 1339 976453 194967 109416540
Obstructive airways disorder 49.12 10.41 225 977567 45924 109565583
C-reactive protein 49.06 10.41 446 977346 29885 109581622
Influenza 48.86 10.41 1893 975899 167208 109444299
Joint laxity 48.75 10.41 83 977709 2424 109609083
Blood alkaline phosphatase increased 48.66 10.41 397 977395 70538 109540969
Eosinophilia 48.61 10.41 306 977486 57630 109553877
Circulatory collapse 48.56 10.41 205 977587 42788 109568719
Coronary artery disease 48.37 10.41 403 977389 71287 109540220
Chronic graft versus host disease 48.32 10.41 12 977780 9445 109602062
Rash erythematous 48.25 10.41 476 977316 81356 109530151
Metastases to bone 48.12 10.41 131 977661 31241 109580266
Parkinsonism 48.11 10.41 76 977716 22111 109589396
Acute myeloid leukaemia 47.97 10.41 174 977618 37936 109573571
Accidental exposure to product 47.93 10.41 253 977539 49755 109561752
Klebsiella infection 47.85 10.41 64 977728 19945 109591562
Cytopenia 47.52 10.41 124 977668 29992 109581515
Abnormal behaviour 47.34 10.41 181 977611 38858 109572649
Second primary malignancy 47.19 10.41 54 977738 18014 109593493
Schizophrenia 47.10 10.41 75 977717 21751 109589756
Laryngitis 47.10 10.41 578 977214 41833 109569674
Erythema multiforme 46.96 10.41 71 977721 21026 109590481
Febrile bone marrow aplasia 46.93 10.41 51 977741 17414 109594093
Migraine 46.91 10.41 1910 975882 169742 109441765
Cardiotoxicity 46.81 10.41 48 977744 16833 109594674
Anuria 46.76 10.41 90 977702 24251 109587256
Pulmonary oedema 46.63 10.41 618 977174 100041 109511466
Leukocytosis 46.36 10.41 282 977510 53546 109557961
Haemodynamic instability 46.30 10.41 82 977710 22806 109588701
Fear 46.10 10.41 84 977708 23109 109588398
Neck pain 46.02 10.41 1420 976372 121710 109489797
Vaginal flatulence 45.94 10.41 25 977767 12119 109599388
Injection site erythema 45.93 10.41 1124 976668 93052 109518455
Pulmonary embolism 45.91 10.41 1495 976297 212979 109398528
Blood phosphorus increased 45.83 10.41 46 977746 16294 109595213
Nocardiosis 45.79 10.41 6 977786 7480 109604027
Irritability 45.75 10.41 242 977550 47567 109563940
Blood calcium decreased 45.56 10.41 163 977629 35682 109575825
Ear infection 45.52 10.41 794 976998 61938 109549569
Hypercholesterolaemia 45.46 10.41 1088 976704 89749 109521758
Intercepted product preparation error 45.45 10.41 4 977788 6816 109604691
Injection site pruritus 45.15 10.41 670 977122 50588 109560919
Spinal stenosis 45.10 10.41 306 977486 18750 109592757
Aspartate aminotransferase increased 44.97 10.41 1073 976719 158863 109452644
Cystitis haemorrhagic 44.94 10.41 26 977766 12183 109599324
Proctitis 44.85 10.41 50 977742 16877 109594630
Jaundice cholestatic 44.67 10.41 38 977754 14570 109596937
Rhinorrhoea 44.42 10.41 1206 976586 101460 109510047
Drug dose omission by device 44.10 10.41 38 977754 14478 109597029
Fall 44.06 10.41 6034 971758 597448 109014059
Diffuse large B-cell lymphoma recurrent 43.93 10.41 3 977789 6296 109605211
Infective pulmonary exacerbation of cystic fibrosis 43.27 10.41 40 977752 14731 109596776
Bradyphrenia 43.13 10.41 25 977767 11703 109599804
Wheelchair user 43.13 10.41 160 977632 7682 109603825
Graft versus host disease in skin 43.11 10.41 10 977782 8244 109603263
Transaminases increased 42.92 10.41 356 977436 63034 109548473
Hypomagnesaemia 42.74 10.41 335 977457 60035 109551472
Ankylosing spondylitis 42.67 10.41 260 977532 15352 109596155
Hepatic encephalopathy 42.58 10.41 119 977673 28137 109583370
Gestational diabetes 42.53 10.41 153 977639 7236 109604271
Tenosynovitis 42.51 10.41 268 977524 16015 109595492
Unintentional medical device removal 42.46 10.41 13 977779 8910 109602597
Mental status changes 42.32 10.41 449 977343 75673 109535834
Ischaemic stroke 42.26 10.41 204 977588 41059 109570448
Prescribed underdose 42.08 10.41 810 976982 64364 109547143
Acute myocardial infarction 41.92 10.41 506 977286 83271 109528236
Acidosis 41.82 10.41 85 977707 22446 109589061
Polyneuropathy 41.74 10.41 144 977648 31868 109579639
Neurologic neglect syndrome 41.72 10.41 178 977614 9120 109602387
Platelet count decreased 41.66 10.41 1640 976152 228803 109382704
Stress cardiomyopathy 41.54 10.41 47 977745 15759 109595748
Asthma-chronic obstructive pulmonary disease overlap syndrome 41.53 10.41 4 977788 6340 109605167
Tendonitis 41.41 10.41 382 977410 25701 109585806
Hepatitis B reactivation 41.27 10.41 8 977784 7476 109604031
Potentiating drug interaction 41.17 10.41 26 977766 11617 109599890
Metastases to lung 41.14 10.41 89 977703 22974 109588533
Femur fracture 41.04 10.41 586 977206 43883 109567624
Pulmonary haemorrhage 41.04 10.41 51 977741 16405 109595102
Poor venous access 40.90 10.41 363 977429 24159 109587348
Pneumonia aspiration 40.89 10.41 490 977302 80743 109530764
Jaundice 40.87 10.41 331 977461 58905 109552602
Diabetes insipidus 40.83 10.41 5 977787 6565 109604942
Neuropathy peripheral 40.70 10.41 1240 976552 178037 109433470
Distributive shock 40.63 10.41 3 977789 5901 109605606
Nephropathy toxic 40.47 10.41 117 977675 27361 109584146
International normalised ratio increased 40.46 10.41 532 977260 86240 109525267
Hyperammonaemia 40.45 10.41 37 977755 13695 109597812
Pemphigoid 40.41 10.41 70 977722 19637 109591870
Hallucination 40.26 10.41 642 977150 100790 109510717
Shock haemorrhagic 40.14 10.41 116 977676 27131 109584376
Carotid artery thrombosis 39.82 10.41 180 977612 9458 109602049
Diabetes mellitus 39.78 10.41 628 977164 98753 109512754
Acute coronary syndrome 39.74 10.41 91 977701 23021 109588486
General physical health deterioration 39.61 10.41 4318 973474 420977 109190530
Pneumothorax 39.39 10.41 169 977623 35116 109576391
Vomiting 39.16 10.41 7274 970518 903401 108708106
Adjustment disorder 39.06 10.41 194 977598 10601 109600906
Acute chest syndrome 38.77 10.41 68 977724 2035 109609472
Respiratory acidosis 38.69 10.41 39 977753 13787 109597720
Myopathy 38.45 10.41 104 977688 24856 109586651
Clostridium difficile colitis 38.41 10.41 228 977564 43550 109567957
Anti-cyclic citrullinated peptide antibody 38.33 10.41 305 977487 19659 109591848
Hepatitis cholestatic 38.25 10.41 60 977732 17506 109594001
Muscle twitching 38.13 10.41 136 977656 29799 109581708
Pneumatosis intestinalis 37.84 10.41 14 977778 8515 109602992
Immune effector cell-associated neurotoxicity syndrome 37.72 10.41 45 977747 14737 109596770
Wheezing 37.70 10.41 2681 975111 252549 109358958
Dissociation 37.61 10.41 20 977772 9822 109601685
Bacteraemia 37.60 10.41 220 977572 42170 109569337
Myocardial ischaemia 37.58 10.41 116 977676 26568 109584939
Hypomania 37.22 10.41 22 977770 10188 109601319
Skin cancer 37.10 10.41 277 977515 17507 109594000
Conjunctivitis allergic 37.00 10.41 8 977784 6923 109604584
Neck mass 36.91 10.41 110 977682 4711 109606796
Colitis 36.91 10.41 659 977133 101664 109509843
Onychomycosis 36.87 10.41 511 977281 38020 109573487
Speech disorder 36.77 10.41 357 977435 61212 109550295
Nausea 36.62 10.41 10048 967744 1225642 108385865
Candida infection 36.56 10.41 261 977531 47748 109563759
End stage renal disease 36.56 10.41 85 977707 21388 109590119
Cytomegalovirus chorioretinitis 36.51 10.41 9 977783 7119 109604388
Exostosis 36.39 10.41 590 977202 45366 109566141
Hepatitis acute 36.39 10.41 69 977723 18697 109592810
Synovial cyst 36.23 10.41 198 977594 11232 109600275
Pulmonary vasculitis 36.20 10.41 7 977785 6553 109604954
Hypogammaglobulinaemia 36.20 10.41 77 977715 19999 109591508
Neck deformity 36.10 10.41 62 977730 1824 109609683
Hypoalbuminaemia 36.00 10.41 133 977659 28841 109582666
Mycotic allergy 35.87 10.41 5 977787 5949 109605558
Device expulsion 35.69 10.41 146 977646 30745 109580762
Female genital tract fistula 35.43 10.41 57 977735 16462 109595045
Haemorrhage intracranial 35.33 10.41 134 977658 28835 109582672
Hyperuricaemia 35.23 10.41 46 977746 14485 109597022
Lupus-like syndrome 35.08 10.41 531 977261 40261 109571246
Toxic encephalopathy 35.04 10.41 50 977742 15164 109596343
Tardive dyskinesia 35.01 10.41 41 977751 13538 109597969
Sleep disorder 34.98 10.41 2118 975674 196526 109414981
Maternal exposure before pregnancy 34.88 10.41 142 977650 7123 109604384
Alanine aminotransferase increased 34.72 10.41 1301 976491 182472 109429035
Bacterial infection 34.70 10.41 251 977541 45785 109565722
Spirometry abnormal 34.61 10.41 4 977788 5493 109606014
Hyperpyrexia 34.55 10.41 14 977778 8055 109603452
Cardiac failure acute 34.39 10.41 104 977688 23974 109587533
Hepatic cytolysis 34.25 10.41 316 977476 54737 109556770
Vasoplegia syndrome 34.14 10.41 4 977788 5435 109606072
Myocarditis 34.13 10.41 143 977649 29912 109581595
Dust allergy 33.98 10.41 6 977786 5995 109605512
Enterocolitis 33.90 10.41 73 977719 18876 109592631
X-ray abnormal 33.87 10.41 499 977293 37618 109573889
Paraesthesia oral 33.60 10.41 168 977624 33503 109578004
Gastroenteritis viral 33.57 10.41 423 977369 30803 109580704
Blood lactic acid increased 33.55 10.41 55 977737 15766 109595741
Tremor 33.41 10.41 1454 976338 200778 109410729
Nail disorder 33.40 10.41 708 977084 57227 109554280
Pulmonary arterial hypertension 33.36 10.41 161 977631 32407 109579100
Intestinal resection 33.32 10.41 93 977699 3836 109607671
Hepatitis fulminant 33.30 10.41 17 977775 8543 109602964
Paradoxical drug reaction 33.25 10.41 23 977769 9794 109601713
Gastrointestinal haemorrhage 33.25 10.41 1163 976629 164355 109447152
Cardiac failure chronic 33.20 10.41 44 977748 13767 109597740
Ileus 33.19 10.41 149 977643 30580 109580927
Atrial tachycardia 33.14 10.41 20 977772 9158 109602349
Sexual dysfunction 33.09 10.41 17 977775 8513 109602994
Sinus bradycardia 33.04 10.41 141 977651 29342 109582165
Hyperlactacidaemia 32.92 10.41 16 977776 8270 109603237
Tongue disorder 32.89 10.41 228 977564 14070 109597437
Cross sensitivity reaction 32.79 10.41 5 977787 5562 109605945
Virologic failure 32.74 10.41 3 977789 4949 109606558
Acute respiratory failure 32.73 10.41 468 977324 74792 109536715
Colorectal cancer 32.71 10.41 20 977772 9094 109602413
Bone marrow failure 32.65 10.41 340 977452 57508 109553999
Fracture 32.54 10.41 349 977443 24439 109587068
Blood urea increased 32.26 10.41 320 977472 54637 109556870
Pulseless electrical activity 32.15 10.41 62 977730 16695 109594812
Subarachnoid haemorrhage 32.10 10.41 144 977648 29558 109581949
Disability 31.89 10.41 408 977384 29815 109581692
Red blood cell sedimentation rate 31.77 10.41 110 977682 5104 109606403
Peripheral sensory neuropathy 31.76 10.41 62 977730 16618 109594889
Onychomadesis 31.72 10.41 574 977218 45089 109566418
Transplant dysfunction 31.72 10.41 17 977775 8311 109603196
Device difficult to use 31.56 10.41 75 977717 18730 109592777
Myasthenia gravis 31.38 10.41 92 977700 21419 109590088
Palmoplantar keratoderma 31.36 10.41 5 977787 5382 109606125
Hallucination, visual 31.29 10.41 213 977579 39392 109572115
Product administered to patient of inappropriate age 31.20 10.41 16 977776 8020 109603487
Intervertebral disc degeneration 30.83 10.41 269 977523 17816 109593691
Dyspnoea 30.73 10.41 9025 968767 1097847 108513660
Immunosuppressant drug level increased 30.66 10.41 35 977757 11689 109599818
Blepharospasm 30.56 10.41 667 977125 54184 109557323
Drug tolerance 30.55 10.41 251 977541 16334 109595173
Strongyloidiasis 30.49 10.41 4 977788 4982 109606525
Bronchitis 30.46 10.41 1689 976103 155343 109456164
Drug effective for unapproved indication 30.27 10.41 49 977743 14118 109597389
Skin toxicity 29.93 10.41 36 977756 11747 109599760
Anal fissure 29.88 10.41 169 977623 9712 109601795
Subdural haematoma 29.84 10.41 194 977598 36260 109575247
Exposure via ingestion 29.80 10.41 4 977788 4896 109606611
Sudden death 29.65 10.41 113 977679 24282 109587225
Oesophageal carcinoma 29.49 10.41 35 977757 11489 109600018
Radiculopathy 29.46 10.41 81 977711 19255 109592252
Bladder cancer 29.45 10.41 87 977705 20205 109591302
Endophthalmitis 29.34 10.41 18 977774 8169 109603338
Chronic kidney disease 29.24 10.41 486 977306 75805 109535702
Pneumonia bacterial 29.18 10.41 126 977666 26135 109585372
Alanine aminotransferase abnormal 29.12 10.41 161 977631 9173 109602334
Acute graft versus host disease in intestine 29.12 10.41 7 977785 5632 109605875
Blood lactate dehydrogenase increased 29.11 10.41 251 977541 44083 109567424
Blood parathyroid hormone decreased 29.10 10.41 207 977585 12882 109598625
Sleep terror 29.07 10.41 11 977781 6599 109604908
Hypocalcaemia 28.95 10.41 405 977387 64961 109546546
Paranoia 28.93 10.41 101 977691 22273 109589234
Venoocclusive disease 28.89 10.41 10 977782 6340 109605167
Human herpesvirus 6 infection 28.87 10.41 11 977781 6570 109604937
Cyanosis 28.76 10.41 150 977642 29591 109581916
Hepatocellular carcinoma 28.66 10.41 27 977765 9853 109601654
Hepatic cirrhosis 28.57 10.41 792 977000 66834 109544673
Bacterial sepsis 28.51 10.41 30 977762 10396 109601111
Hypernatraemia 28.46 10.41 73 977719 17760 109593747
Pruritus genital 28.44 10.41 11 977781 6511 109604996
Pulmonary congestion 28.39 10.41 159 977633 30807 109580700
Intestinal stenosis 28.32 10.41 99 977693 4616 109606891
Mouth ulceration 28.31 10.41 590 977202 47548 109563959
Foot fracture 28.30 10.41 348 977444 25198 109586309
Hypertriglyceridaemia 28.27 10.41 63 977729 16091 109595416
Procedural pain 28.24 10.41 191 977601 35374 109576133
Drug ineffective 28.23 10.41 12588 965204 1507952 108103555
Vision blurred 28.16 10.41 897 976895 128125 109483382
Emotional distress 28.08 10.41 257 977535 44590 109566917
Kidney transplant rejection 28.00 10.41 39 977753 11948 109599559
Lupus vulgaris 27.96 10.41 438 977354 33445 109578062
Cyst 27.93 10.41 245 977547 16251 109595256
Lung disorder 27.93 10.41 1899 975893 178148 109433359
Oliguria 27.80 10.41 79 977713 18578 109592929
Glycosylated haemoglobin increased 27.68 10.41 111 977681 23508 109587999
Activated partial thromboplastin time prolonged 27.58 10.41 103 977689 22265 109589242
Retinitis 27.48 10.41 420 977372 31907 109579600
Joint dislocation 27.47 10.41 440 977352 33750 109577757
Device use error 27.36 10.41 24 977768 9065 109602442
Tooth disorder 27.29 10.41 389 977403 29120 109582387
Granuloma skin 27.19 10.41 182 977610 11101 109600406
Injection site bruising 27.18 10.41 619 977173 50644 109560863
Cardiomyopathy 27.14 10.41 179 977613 33346 109578161
Multiple fractures 27.09 10.41 153 977639 8787 109602720
Chronic sinusitis 26.87 10.41 122 977670 24962 109586545
Smear cervix abnormal 26.86 10.41 68 977724 2644 109608863
Heparin-induced thrombocytopenia 26.85 10.41 37 977755 11387 109600120
Metastases to lymph nodes 26.82 10.41 58 977734 14974 109596533
Finger deformity 26.63 10.41 426 977366 32666 109578841
Renal injury 26.60 10.41 81 977711 18632 109592875
Vitamin B12 deficiency 26.56 10.41 166 977626 9889 109601618
Premature labour 26.51 10.41 155 977637 9017 109602490
Ketoacidosis 26.50 10.41 30 977762 10057 109601450
Erythema 26.45 10.41 2217 975575 289230 109322277
Hypercapnia 26.37 10.41 36 977756 11123 109600384
Accidental death 26.30 10.41 6 977786 5003 109606504
Arthritis infective 26.21 10.41 170 977622 10259 109601248
Hyperphosphataemia 26.19 10.41 67 977725 16314 109595193
Dermatitis acneiform 26.12 10.41 45 977747 12650 109598857
Latent tuberculosis 26.08 10.41 86 977706 3891 109607616
Product prescribing error 26.07 10.41 309 977483 51022 109560485
Acute pulmonary oedema 26.04 10.41 71 977721 16925 109594582
Tenderness 26.01 10.41 385 977407 29052 109582455
Premature rupture of membranes 25.83 10.41 95 977697 4542 109606965
Complications of transplanted kidney 25.79 10.41 17 977775 7425 109604082
Haemorrhage 25.69 10.41 732 977060 105960 109505547
Muscle rigidity 25.67 10.41 117 977675 23914 109587593
Postoperative wound infection 25.66 10.41 232 977560 15521 109595986
Dyskinesia 25.63 10.41 311 977481 51135 109560372
Breast cancer stage I 25.43 10.41 17 977775 7370 109604137
Vasculitis 25.42 10.41 199 977593 35674 109575833
Osteonecrosis 25.42 10.41 184 977608 33557 109577950
Device related infection 25.39 10.41 225 977567 39294 109572213
Vitamin D decreased 25.33 10.41 190 977602 12025 109599482
Purpura 25.31 10.41 120 977672 24268 109587239
Scleritis 25.28 10.41 105 977687 5315 109606192
Congestive cardiomyopathy 25.25 10.41 55 977737 14164 109597343
Progressive multifocal leukoencephalopathy 25.20 10.41 124 977668 24832 109586675
Vaginal discharge 25.12 10.41 78 977714 17830 109593677
Back injury 25.03 10.41 572 977220 46827 109564680
Hydrocephalus 25.00 10.41 33 977759 10342 109601165
Oedema 24.98 10.41 2169 975623 207807 109403700
COVID-19 pneumonia 24.96 10.41 209 977583 36934 109574573
Maternal exposure timing unspecified 24.92 10.41 290 977502 20723 109590784
Nephrectomy 24.91 10.41 65 977727 2575 109608932
Intracranial pressure increased 24.88 10.41 34 977758 10501 109601006
Brain injury 24.88 10.41 51 977741 13425 109598082
Skin ulcer 24.85 10.41 738 977054 62907 109548600
Acute lymphocytic leukaemia recurrent 24.84 10.41 10 977782 5777 109605730
Rotator cuff repair 24.76 10.41 59 977733 2207 109609300
Disturbance in social behaviour 24.74 10.41 7 977785 5051 109606456
Hypoxic-ischaemic encephalopathy 24.71 10.41 25 977767 8822 109602685
Bradypnoea 24.66 10.41 24 977768 8625 109602882
Vitamin B12 decreased 24.65 10.41 102 977690 5155 109606352
Limb deformity 24.56 10.41 81 977711 3665 109607842
Accidental overdose 24.46 10.41 317 977475 51517 109559990
Cataract 24.44 10.41 896 976896 78589 109532918
Nodule 24.39 10.41 415 977377 32216 109579291
Dry skin 24.33 10.41 745 977047 106908 109504599
Enterococcal infection 24.32 10.41 95 977697 20271 109591236
Cystitis 24.25 10.41 760 977032 65276 109546231
Hyperprolactinaemia 24.20 10.41 14 977778 6561 109604946
Hyperthermia malignant 24.16 10.41 3 977789 3897 109607610
Left ventricular dysfunction 24.14 10.41 116 977676 23377 109588130
Lymphopenia 23.95 10.41 233 977559 39937 109571570
Vascular stent thrombosis 23.92 10.41 4 977788 4157 109607350
Post procedural infection 23.85 10.41 206 977586 13603 109597904
Generalised oedema 23.83 10.41 166 977626 30538 109580969
Joint injury 23.79 10.41 491 977301 39503 109572004
Eosinophilic granulomatosis with polyangiitis 23.75 10.41 36 977756 10650 109600857
Total lung capacity decreased 23.66 10.41 17 977775 7097 109604410
Dehydration 23.62 10.41 2138 975654 277373 109334134
Hypophosphataemia 23.55 10.41 184 977608 32998 109578509
Nasal polyps 23.49 10.41 51 977741 13149 109598358
Foot operation 23.39 10.41 127 977665 7186 109604321
Ventricular arrhythmia 23.38 10.41 33 977759 10054 109601453
Lung opacity 23.34 10.41 42 977750 11610 109599897
Prescribed overdose 23.33 10.41 972 976820 86609 109524898
Food allergy 23.22 10.41 94 977698 19854 109591653
Urinary retention 23.20 10.41 455 977337 69228 109542279
Euglycaemic diabetic ketoacidosis 23.19 10.41 42 977750 11581 109599926
Hyperlipidaemia 23.07 10.41 204 977588 35644 109575863
Visual acuity reduced 23.02 10.41 178 977614 31995 109579512
Varicella zoster virus infection 22.82 10.41 14 977778 6354 109605153
Macular degeneration 22.81 10.41 106 977686 21553 109589954
Blood pressure decreased 22.81 10.41 810 976982 114281 109497226
Neurological symptom 22.59 10.41 67 977725 15541 109595966
Atrioventricular block complete 22.53 10.41 96 977696 19986 109591521
Hypotonia 22.49 10.41 68 977724 15677 109595830
Herpes zoster 22.47 10.41 1173 976619 107206 109504301
Seronegative arthritis 22.46 10.41 196 977596 12981 109598526
Muscle spasms 22.37 10.41 2798 974994 275359 109336148
Sensory loss 22.36 10.41 289 977503 21168 109590339
Pre-eclampsia 22.35 10.41 142 977650 8508 109602999
Anti-neutrophil cytoplasmic antibody positive vasculitis 22.23 10.41 10 977782 5407 109606100
Skin papilloma 22.22 10.41 120 977672 6776 109604731
Bronchopulmonary aspergillosis allergic 22.20 10.41 25 977767 8401 109603106
Malignant mediastinal neoplasm 22.16 10.41 42 977750 1336 109610171
Renal tubular necrosis 22.09 10.41 168 977624 30307 109581200
Labelled drug-drug interaction medication error 21.97 10.41 160 977632 29142 109582365
Pneumocystis jirovecii pneumonia 21.80 10.41 257 977535 42478 109569029
Total lung capacity increased 21.68 10.41 9 977783 5103 109606404
Type I hypersensitivity 21.63 10.41 15 977777 6378 109605129
Cryptococcosis 21.58 10.41 7 977785 4624 109606883
Type 1 diabetes mellitus 21.57 10.41 29 977763 9018 109602489
Sinus congestion 21.55 10.41 384 977408 30075 109581432
Hepatic necrosis 21.50 10.41 34 977758 9888 109601619
Rheumatoid lung 21.36 10.41 85 977707 4219 109607288
Injection site swelling 21.36 10.41 706 977086 61084 109550423
Glomerular filtration rate decreased 21.29 10.41 159 977633 28797 109582710
Chronic disease 21.07 10.41 17 977775 214 109611293
Device leakage 21.05 10.41 72 977720 15976 109595531
Immune-mediated enterocolitis 21.05 10.41 36 977756 10149 109601358
Faecal calprotectin increased 21.03 10.41 116 977676 6603 109604904
Nephrotic syndrome 21.03 10.41 58 977734 13773 109597734
Hydrops foetalis 20.97 10.41 30 977762 751 109610756
Antinuclear antibody positive 20.97 10.41 146 977646 9022 109602485
Cleft lip and palate 20.97 10.41 29 977763 703 109610804
Metabolic disorder 20.95 10.41 38 977754 10472 109601035
Drug tolerance decreased 20.86 10.41 351 977441 27189 109584318
Panniculitis 20.74 10.41 220 977572 15362 109596145
Clonus 20.72 10.41 28 977764 8688 109602819
Synovial disorder 20.60 10.41 66 977726 2941 109608566
Blood uric acid increased 20.59 10.41 109 977683 21420 109590087
Haematemesis 20.58 10.41 383 977409 58725 109552782
Injection site rash 20.58 10.41 306 977486 23113 109588394
Toxic anterior segment syndrome 20.58 10.41 3 977789 3451 109608056
Hepatitis C 20.43 10.41 51 977741 12522 109598985
Gene mutation 20.38 10.41 3 977789 3426 109608081
Personality disorder 20.38 10.41 188 977604 12649 109598858
Hypertensive crisis 20.30 10.41 129 977663 24243 109587264
Acute myeloid leukaemia recurrent 20.30 10.41 10 977782 5129 109606378
Spinal osteoarthritis 20.26 10.41 270 977522 19913 109591594
Methaemoglobinaemia 20.26 10.41 31 977761 9137 109602370
Red blood cell count decreased 20.23 10.41 743 977049 65180 109546327
Back disorder 20.23 10.41 278 977514 20644 109590863
Osteopenia 20.23 10.41 292 977500 21917 109589590
Kounis syndrome 19.91 10.41 14 977778 5911 109605596
Sleep disorder therapy 19.87 10.41 22 977770 7449 109604058
Bone disorder 19.85 10.41 280 977512 20912 109590595
Diplopia 19.84 10.41 256 977536 41638 109569869
Hepatitis B 19.84 10.41 34 977758 9578 109601929
Gastric haemorrhage 19.81 10.41 73 977719 15842 109595665
Burning sensation 19.79 10.41 774 977018 68438 109543069
Paralysis 19.78 10.41 71 977721 15529 109595978
Nervous system disorder 19.77 10.41 182 977610 31539 109579968
Lip swelling 19.67 10.41 322 977470 50345 109561162
Wrong patient received product 19.64 10.41 18 977774 6656 109604851
Nasal congestion 19.63 10.41 1060 976732 97222 109514285
Pseudomonal sepsis 19.60 10.41 31 977761 9015 109602492
Hand fracture 19.56 10.41 131 977661 7991 109603516
Aspiration 19.54 10.41 174 977618 30359 109581148
Pancreatitis 19.52 10.41 654 977138 92879 109518628
Chest discomfort 19.50 10.41 1299 976493 172549 109438958
Epstein-Barr virus associated lymphoproliferative disorder 19.50 10.41 9 977783 4793 109606714
Nail operation 19.48 10.41 45 977747 1649 109609858
Neuritis 19.45 10.41 22 977770 7377 109604130
Haematuria 19.35 10.41 572 977220 82433 109529074
Exposure via skin contact 19.35 10.41 56 977736 13091 109598416
Infection reactivation 19.32 10.41 6 977786 4075 109607432
Therapeutic reaction time decreased 19.19 10.41 95 977697 5184 109606323
Laryngeal oedema 19.07 10.41 36 977756 9771 109601736
Systemic candida 19.05 10.41 37 977755 9937 109601570
Catatonia 19.02 10.41 45 977747 11255 109600252
Cholangitis 19.00 10.41 77 977715 16258 109595249
Arteriospasm coronary 18.96 10.41 32 977760 9068 109602439
Hallucination, auditory 18.91 10.41 146 977646 26251 109585256
Delayed graft function 18.86 10.41 7 977785 4250 109607257
Tubulointerstitial nephritis 18.82 10.41 352 977440 53932 109557575
Ultrasound antenatal screen 18.78 10.41 27 977765 679 109610828
Tuberculosis 18.78 10.41 240 977552 17534 109593973
Hypoglycaemic coma 18.69 10.41 13 977779 5520 109605987
Amylase increased 18.66 10.41 53 977739 12466 109599041
Lower respiratory tract congestion 18.65 10.41 88 977704 4708 109606799
Pulmonary pain 18.61 10.41 107 977685 6186 109605321
Pulmonary hypertension 18.55 10.41 360 977432 54860 109556647
Cytomegalovirus colitis 18.55 10.41 21 977771 7040 109604467
Ejection fraction abnormal 18.54 10.41 70 977722 3390 109608117
Synovial fluid analysis 18.51 10.41 59 977733 2622 109608885
Blindness 18.42 10.41 219 977573 36140 109575367
Ankle arthroplasty 18.40 10.41 57 977735 2494 109609013
Hypertransaminasaemia 18.40 10.41 132 977660 24123 109587384
Gastric cancer 18.40 10.41 44 977748 10964 109600543
Right ventricular failure 18.38 10.41 144 977648 25810 109585697
Metastasis 18.23 10.41 28 977764 8239 109603268
Linear IgA disease 18.17 10.41 8 977784 4381 109607126
Surgery 18.15 10.41 486 977306 40797 109570710
Gingival pain 18.14 10.41 216 977576 15520 109595987
Staphylococcal infection 18.10 10.41 475 977317 69469 109542038
Lymphocyte count decreased 18.09 10.41 377 977415 56866 109554641
Increased tendency to bruise 18.06 10.41 171 977621 11587 109599920
Magnesium deficiency 18.00 10.41 28 977764 757 109610750
Haemoglobin decreased 17.99 10.41 2486 975306 246241 109365266
Ulcer haemorrhage 17.95 10.41 290 977502 22281 109589226
Memory impairment 17.95 10.41 1997 975795 194947 109416560
Mite allergy 17.86 10.41 15 977777 5788 109605719
Loose body in joint 17.76 10.41 39 977753 1381 109610126
Tenosynovitis stenosans 17.76 10.41 71 977721 3532 109607975
Bone density abnormal 17.73 10.41 75 977717 3828 109607679
Reversible cerebral vasoconstriction syndrome 17.72 10.41 10 977782 4751 109606756
Analgesic therapy 17.72 10.41 23 977769 7261 109604246
Eyelid oedema 17.72 10.41 72 977720 15190 109596317
Dermatitis exfoliative 17.69 10.41 47 977745 11300 109600207
Epistaxis 17.66 10.41 957 976835 129415 109482092
Haematoma 17.64 10.41 388 977404 58088 109553419
Epstein-Barr virus infection reactivation 17.63 10.41 7 977785 4077 109607430
Fracture delayed union 17.60 10.41 51 977741 2150 109609357
Abortion incomplete 17.55 10.41 3 977789 3069 109608438
Neutrophilia 17.49 10.41 41 977751 10288 109601219
Spondylitis 17.47 10.41 165 977627 11173 109600334
Epstein-Barr viraemia 17.42 10.41 5 977787 3574 109607933
Wrong product administered 17.39 10.41 45 977747 10915 109600592
Gastrooesophageal reflux disease 17.38 10.41 1832 975960 178144 109433363
Hyperthyroidism 17.33 10.41 170 977622 29091 109582416
Benign ovarian tumour 17.32 10.41 21 977771 445 109611062
Cerebral haematoma 17.32 10.41 37 977755 9595 109601912
Compartment syndrome 17.32 10.41 16 977776 5894 109605613
Mental disorder 17.30 10.41 240 977552 38551 109572956
Sinus disorder 17.29 10.41 395 977397 32333 109579174
Blood iron decreased 17.26 10.41 252 977540 18962 109592545
Affective disorder 17.19 10.41 47 977745 11194 109600313
Sputum discoloured 17.13 10.41 161 977631 27784 109583723
Laryngospasm 17.10 10.41 10 977782 4658 109606849
Headache 17.05 10.41 8321 969471 874056 108737451
Product administration error 17.05 10.41 229 977563 36988 109574519
Pharyngitis streptococcal 17.00 10.41 186 977606 13091 109598416
Urinary tract infection 16.98 10.41 3203 974589 323079 109288428
Malignant melanoma 16.98 10.41 226 977566 16665 109594842
Secondary adrenocortical insufficiency 16.96 10.41 9 977783 4425 109607082
Drug screen positive 16.91 10.41 19 977773 6391 109605116
Breast feeding 16.90 10.41 26 977766 696 109610811
Dyslipidaemia 16.89 10.41 78 977714 15887 109595620
Trisomy 18 16.89 10.41 24 977768 597 109610910
Mucocutaneous ulceration 16.88 10.41 27 977765 748 109610759
Tumour haemorrhage 16.84 10.41 13 977779 5232 109606275
Pneumomediastinum 16.79 10.41 12 977780 5024 109606483
Neoplasm recurrence 16.76 10.41 13 977779 5219 109606288
Drug therapy 16.75 10.41 24 977768 7267 109604240
Aplastic anaemia 16.69 10.41 136 977656 24172 109587335
Heart rate irregular 16.69 10.41 409 977383 33865 109577642
White blood cell count decreased 16.67 10.41 1774 976018 227616 109383891
Polyomavirus viraemia 16.64 10.41 5 977787 3469 109608038
Paraesthesia 16.61 10.41 2735 975057 273786 109337721
Behaviour disorder 16.57 10.41 38 977754 9609 109601898
Affect lability 16.57 10.41 244 977548 18393 109593114
Ingrown hair 16.54 10.41 27 977765 761 109610746
Rash morbilliform 16.53 10.41 28 977764 7923 109603584
Clostridium test positive 16.52 10.41 158 977634 10735 109600772
Abdominal pain upper 16.52 10.41 3411 974381 345700 109265807
Amyloid arthropathy 16.51 10.41 42 977750 1638 109609869
Accidental exposure to product by child 16.45 10.41 4 977788 3194 109608313
Immunisation 16.34 10.41 4 977788 3179 109608328
Sleep apnoea syndrome 16.33 10.41 471 977321 39976 109571531
Brain natriuretic peptide increased 16.31 10.41 48 977744 11161 109600346
Walking aid user 16.31 10.41 312 977480 24763 109586744
Colitis microscopic 16.30 10.41 62 977730 13332 109598175
Hypertonia 16.22 10.41 31 977761 8375 109603132
Viraemia 16.18 10.41 8 977784 4094 109607413
Colitis ulcerative 16.17 10.41 838 976954 76525 109534982
Knee operation 16.17 10.41 112 977680 6910 109604597
Coma scale abnormal 16.16 10.41 39 977753 9687 109601820
Bradyarrhythmia 16.14 10.41 12 977780 4922 109606585
Systemic inflammatory response syndrome 16.12 10.41 60 977732 12983 109598524
Blood folate increased 16.10 10.41 23 977769 575 109610932
Psychotic symptom 16.09 10.41 7 977785 3860 109607647
Swelling face 16.03 10.41 660 977132 91661 109519846
Leukoencephalopathy 15.97 10.41 36 977756 9159 109602348
Capillary leak syndrome 15.97 10.41 12 977780 4896 109606611
Benign neoplasm of adrenal gland 15.96 10.41 9 977783 59 109611448
Aphthous ulcer 15.87 10.41 269 977523 20867 109590640
Swollen tongue 15.87 10.41 409 977383 59953 109551554
Ileus paralytic 15.85 10.41 52 977740 11685 109599822
Cardiac dysfunction 15.82 10.41 19 977773 6204 109605303
Staphylococcal sepsis 15.79 10.41 90 977702 17364 109594143
Polyuria 15.76 10.41 92 977700 17646 109593861
Staphylococcal bacteraemia 15.67 10.41 85 977707 16603 109594904
Polyhydramnios 15.66 10.41 45 977747 1888 109609619
Adverse drug reaction 15.60 10.41 1109 976683 104450 109507057
Joint noise 15.57 10.41 88 977704 5055 109606452
Human antichimeric antibody positive 15.54 10.41 42 977750 1700 109609807
Hiatus hernia 15.47 10.41 336 977456 27270 109584237
Haematocrit decreased 15.45 10.41 724 977068 65393 109546114
Bronchial secretion retention 15.45 10.41 13 977779 5011 109606496
Drug abuser 15.43 10.41 15 977777 5394 109606113
Vascular purpura 15.42 10.41 7 977785 3764 109607743
Rhinovirus infection 15.39 10.41 53 977739 11736 109599771
Rales 15.39 10.41 142 977650 24597 109586910
Eye movement disorder 15.39 10.41 40 977752 9688 109601819
Cardiopulmonary failure 15.37 10.41 29 977763 7874 109603633
Chills 15.34 10.41 1463 976329 189117 109422390
Purging 15.31 10.41 8 977784 44 109611463
Pulmonary function test abnormal 15.30 10.41 13 977779 4987 109606520
Autoimmune hepatitis 15.27 10.41 73 977719 14731 109596776
Fanconi syndrome 15.24 10.41 6 977786 3513 109607994
Aplasia 15.22 10.41 29 977763 7844 109603663
Persecutory delusion 15.17 10.41 20 977772 6271 109605236
Kidney infection 15.13 10.41 314 977478 25285 109586222
Hallucinations, mixed 15.13 10.41 34 977758 8659 109602848
Frequent bowel movements 15.07 10.41 774 977018 70616 109540891
Paronychia 15.02 10.41 49 977743 11032 109600475
Full blood count decreased 15.02 10.41 381 977411 31718 109579789
Dermatitis bullous 15.01 10.41 92 977700 17437 109594070
Antibody test positive 14.99 10.41 61 977731 3059 109608448
Ileal stenosis 14.98 10.41 63 977729 3207 109608300
Lipase increased 14.96 10.41 100 977692 18572 109592935
Pericardial effusion 14.96 10.41 388 977404 56829 109554678
Liver transplant rejection 14.92 10.41 8 977784 3910 109607597
Short stature 14.92 10.41 31 977761 1056 109610451
Normochromic normocytic anaemia 14.90 10.41 62 977730 12995 109598512
Tonsillar inflammation 14.87 10.41 13 977779 184 109611323
Troponin increased 14.81 10.41 180 977612 29586 109581921
Hyperventilation 14.77 10.41 36 977756 8911 109602596
Fistula 14.68 10.41 203 977589 15096 109596411
Acoustic neuroma 14.63 10.41 16 977776 302 109611205
Salivary hypersecretion 14.62 10.41 92 977700 17329 109594178
Obsessive-compulsive disorder 14.59 10.41 26 977766 7215 109604292
Transplant failure 14.54 10.41 17 977775 5618 109605889
Immune-mediated hepatitis 14.54 10.41 23 977769 6688 109604819
Anticholinergic syndrome 14.53 10.41 10 977782 4270 109607237
Dry throat 14.52 10.41 135 977657 9103 109602404
Steroid diabetes 14.50 10.41 15 977777 5239 109606268
Dyspepsia 14.46 10.41 1914 975878 189051 109422456
Palindromic rheumatism 14.44 10.41 18 977774 393 109611114
Tooth fracture 14.43 10.41 179 977613 12988 109598519
Lethargy 14.39 10.41 678 977114 92898 109518609
Anosmia 14.38 10.41 59 977733 12413 109599094
Injection site warmth 14.36 10.41 225 977567 17180 109594327
Product prescribing issue 14.36 10.41 61 977731 12711 109598796
Retinal haemorrhage 14.33 10.41 40 977752 9461 109602046
Lymphatic fistula 14.30 10.41 37 977755 1458 109610049
Acute lung injury 14.27 10.41 5 977787 3146 109608361
Polydipsia 14.27 10.41 29 977763 7659 109603848
Ligament rupture 14.23 10.41 72 977720 3963 109607544
Porphyria acute 14.09 10.41 239 977553 18541 109592966
Femoral hernia incarcerated 14.08 10.41 37 977755 1472 109610035
Endodontic procedure 14.04 10.41 60 977732 3076 109608431
Immune thrombocytopenia 14.04 10.41 129 977663 22365 109589142
Fungaemia 14.02 10.41 20 977772 6066 109605441
Hypothyroidism 14 10.41 515 977277 72384 109539123
Hepatic cancer 14.00 10.41 51 977741 11105 109600402
Maternal exposure during delivery 13.99 10.41 7 977785 3558 109607949
Hypopituitarism 13.95 10.41 11 977781 4379 109607128
Pneumonia fungal 13.94 10.41 75 977717 14679 109596828
Malaise 13.92 10.41 6350 971442 665469 108946038
Eosinophil count increased 13.92 10.41 119 977673 20939 109590568
Areflexia 13.92 10.41 24 977768 6745 109604762
Placental disorder 13.87 10.41 29 977763 992 109610515
Lip oedema 13.83 10.41 29 977763 7571 109603936
Small intestinal obstruction 13.81 10.41 378 977414 31835 109579672
Insomnia 13.72 10.41 3488 974304 357102 109254405
Tooth infection 13.63 10.41 274 977518 21942 109589565
Mycobacterium chelonae infection 13.61 10.41 5 977787 3055 109608452
Renal cancer 13.60 10.41 64 977728 12970 109598537
Lacrimal disorder 13.54 10.41 20 977772 516 109610991
Drug clearance decreased 13.51 10.41 10 977782 4112 109607395
Hernia 13.50 10.41 245 977547 19255 109592252
Quadriparesis 13.49 10.41 13 977779 4694 109606813
Eye pruritus 13.49 10.41 206 977586 32569 109578938
Cardiac septal defect 13.49 10.41 28 977764 953 109610554
Cerebellar haemorrhage 13.48 10.41 6 977786 3265 109608242
Enterobacter infection 13.48 10.41 19 977773 5792 109605715
Diaphragmatic disorder 13.47 10.41 42 977750 1844 109609663
Bone pain 13.46 10.41 456 977336 64677 109546830
Rash pruritic 13.42 10.41 1024 976768 97045 109514462
Nasal oedema 13.41 10.41 105 977687 6734 109604773
Anal fistula 13.40 10.41 124 977668 8349 109603158
Metastases to peritoneum 13.36 10.41 18 977774 5592 109605915
Foetal distress syndrome 13.35 10.41 22 977770 625 109610882
Cardiac tamponade 13.34 10.41 53 977739 11254 109600253
Muscular weakness 13.33 10.41 2443 975349 246025 109365482
Acrochordon 13.28 10.41 35 977757 1395 109610112
Atrioventricular block 13.22 10.41 91 977701 16786 109594721
Fluid retention 13.20 10.41 690 977102 93617 109517890
Maternal exposure during breast feeding 13.16 10.41 73 977719 4165 109607342
Acquired gene mutation 13.13 10.41 4 977788 2750 109608757
Copper deficiency 13.11 10.41 12 977780 181 109611326
Wound infection pseudomonas 13.10 10.41 49 977743 2362 109609145
Coronary arterial stent insertion 13.07 10.41 20 977772 5895 109605612
Skin neoplasm excision 13.05 10.41 44 977748 2014 109609493
Small for dates baby 12.98 10.41 22 977770 640 109610867
Coronary artery stenosis 12.96 10.41 70 977722 13688 109597819
Fixed eruption 12.95 10.41 11 977781 4221 109607286
Myofascial pain syndrome 12.92 10.41 51 977741 2522 109608985
Eye infection 12.88 10.41 190 977602 14328 109597179
Pain in jaw 12.86 10.41 349 977443 50828 109560679
Hypertension 12.86 10.41 4854 972938 505230 109106277
Viral haemorrhagic cystitis 12.85 10.41 7 977785 3392 109608115
Benign abdominal neoplasm 12.85 10.41 15 977777 305 109611202
Pupillary reflex impaired 12.83 10.41 10 977782 4005 109607502
Anaesthetic complication 12.82 10.41 8 977784 3598 109607909
Meniscus injury 12.81 10.41 115 977677 7678 109603829
Ventricular extrasystoles 12.80 10.41 133 977659 22508 109588999
Corneal oedema 12.80 10.41 6 977786 3167 109608340
Psychomotor skills impaired 12.78 10.41 27 977765 7031 109604476
Incoherent 12.74 10.41 35 977757 8323 109603184
Body height below normal 12.73 10.41 44 977748 2040 109609467
Prescription drug used without a prescription 12.72 10.41 18 977774 5478 109606029
Angina unstable 12.67 10.41 89 977703 16343 109595164
Extradural haematoma 12.65 10.41 7 977785 3362 109608145
Joint lock 12.64 10.41 64 977728 3524 109607983
Tender joint count increased 12.64 10.41 17 977775 401 109611106
Tooth abscess 12.64 10.41 235 977557 18554 109592953
Granulocyte count decreased 12.57 10.41 10 977782 3964 109607543
Lung transplant 12.55 10.41 17 977775 5269 109606238
Disinhibition 12.53 10.41 6 977786 3128 109608379
Gait spastic 12.49 10.41 36 977756 1513 109609994
Thirst 12.49 10.41 127 977665 21580 109589927
Radiation pneumonitis 12.46 10.41 13 977779 4523 109606984
Arteriosclerosis coronary artery 12.45 10.41 152 977640 24966 109586541
Incorrect route of product administration 12.43 10.41 452 977340 63609 109547898
Lipodystrophy acquired 12.39 10.41 13 977779 4511 109606996
Inadequate analgesia 12.38 10.41 16 977776 5061 109606446
Psychomotor retardation 12.36 10.41 32 977760 7760 109603747
Syringe issue 12.31 10.41 43 977749 9482 109602025
On and off phenomenon 12.30 10.41 74 977718 4350 109607157
Nightmare 12.27 10.41 256 977536 38607 109572900
Myringotomy 12.26 10.41 6 977786 28 109611479
Sickle cell anaemia 12.25 10.41 24 977768 783 109610724
Hypervolaemia 12.25 10.41 338 977454 49122 109562385
Pancreatic carcinoma 12.24 10.41 79 977713 14793 109596714
Nephrolithiasis 12.22 10.41 709 977083 65503 109546004
Erectile dysfunction 12.21 10.41 105 977687 18451 109593056
Gastrointestinal anastomotic stenosis 12.21 10.41 8 977784 71 109611436
Disorganised speech 12.21 10.41 7 977785 3296 109608211
Intraocular pressure increased 12.19 10.41 52 977740 10824 109600683
Arthropod bite 12.16 10.41 135 977657 9536 109601971
Vein disorder 12.15 10.41 96 977696 6174 109605333
Throat lesion 12.14 10.41 18 977774 466 109611041
Immune-mediated myocarditis 12.11 10.41 8 977784 3490 109608017
Genital haemorrhage 12.11 10.41 29 977763 7223 109604284
Hypocoagulable state 12.10 10.41 4 977788 2611 109608896
Injection site pain 12.09 10.41 1772 976020 176150 109435357
Bone density increased 12.08 10.41 27 977765 968 109610539
Iodine allergy 12.07 10.41 22 977770 679 109610828
Alcohol interaction 12.06 10.41 9 977783 3685 109607822
Tension headache 12.05 10.41 44 977748 9574 109601933
Apnoea 11.98 10.41 71 977721 13568 109597939
Toothache 11.98 10.41 283 977509 23292 109588215
Rotator cuff syndrome 11.98 10.41 212 977580 16582 109594925
Metabolic surgery 11.97 10.41 34 977758 1417 109610090
Confusional state 11.96 10.41 4462 973330 464218 109147289
Drug eruption 11.96 10.41 372 977420 53287 109558220
Metamyelocyte count increased 11.96 10.41 22 977770 684 109610823
Menstruation delayed 11.95 10.41 39 977753 1755 109609752
Dysstasia 11.95 10.41 379 977413 32607 109578900
Coronary artery bypass 11.90 10.41 22 977770 6020 109605487
Impaired work ability 11.90 10.41 312 977480 26107 109585400
Eczema 11.88 10.41 520 977272 71773 109539734
Haemorrhagic transformation stroke 11.86 10.41 6 977786 3031 109608476
Eating disorder 11.82 10.41 357 977435 30501 109581006
Mitochondrial toxicity 11.82 10.41 7 977785 3238 109608269
Muscle spasticity 11.81 10.41 408 977384 35507 109576000
Normal newborn 11.80 10.41 265 977527 21631 109589876
Lymph gland infection 11.80 10.41 21 977771 636 109610871
Iritis 11.79 10.41 76 977716 4576 109606931
Extravascular haemolysis 11.78 10.41 17 977775 429 109611078
Pancreatitis necrotising 11.78 10.41 19 977773 5482 109606025
Pallor 11.74 10.41 395 977397 56072 109555435
Pernicious anaemia 11.72 10.41 23 977769 751 109610756
Pelvic fracture 11.69 10.41 183 977609 13971 109597536
Oculogyric crisis 11.68 10.41 10 977782 3822 109607685
Coccydynia 11.68 10.41 49 977743 2492 109609015
Pneumonitis 11.67 10.41 555 977237 75976 109535531
Meningitis cryptococcal 11.62 10.41 15 977777 4747 109606760
Product preparation error 11.60 10.41 53 977739 10826 109600681
Prostatic specific antigen increased 11.60 10.41 64 977728 12447 109599060
Pancreatic steatosis 11.59 10.41 39 977753 1783 109609724
Intervertebral disc protrusion 11.59 10.41 324 977468 27374 109584133
Metastases to skin 11.59 10.41 3 977789 2296 109609211
Device loosening 11.54 10.41 24 977768 818 109610689
Gastrointestinal perforation 11.53 10.41 31 977761 7425 109604082
Bone fissure 11.51 10.41 20 977772 594 109610913
Personality change 11.49 10.41 54 977738 10948 109600559
Concomitant disease aggravated 11.49 10.41 91 977701 16273 109595234
Upper respiratory tract inflammation 11.48 10.41 13 977779 4358 109607149
Defaecation disorder 11.48 10.41 24 977768 821 109610686
Liver disorder 11.45 10.41 1431 976361 140812 109470695
Cholecystitis acute 11.44 10.41 87 977705 15695 109595812
Necrotising fasciitis 11.42 10.41 32 977760 7559 109603948
Neutropenic colitis 11.40 10.41 35 977757 8030 109603477
Malignant lymphoid neoplasm 11.34 10.41 4 977788 6 109611501
Upper respiratory tract infection 11.33 10.41 1327 976465 130001 109481506
Haemodialysis 11.33 10.41 101 977691 17618 109593889
Post-traumatic stress disorder 11.32 10.41 26 977766 6570 109604937
Hepatosplenomegaly 11.29 10.41 28 977764 6891 109604616
Tonic clonic movements 11.28 10.41 6 977786 2946 109608561
Mean cell volume increased 11.27 10.41 118 977674 8212 109603295
Underdose 11.25 10.41 678 977114 62876 109548631
Bradykinesia 11.24 10.41 53 977739 10735 109600772
Spinal cord compression 11.24 10.41 32 977760 7520 109603987
Atrial flutter 11.22 10.41 149 977643 24113 109587394
Vasa praevia 11.21 10.41 3 977789 0 109611507
Red blood cell count 11.21 10.41 3 977789 0 109611507
Palpitations 11.20 10.41 1234 976558 157978 109453529
Musculoskeletal discomfort 11.19 10.41 280 977512 23258 109588249
Treatment noncompliance 11.19 10.41 529 977263 72461 109539046
Hypovolaemia 11.19 10.41 130 977662 21544 109589963
Peripheral sensorimotor neuropathy 11.17 10.41 11 977781 3932 109607575
Hypertensive emergency 11.15 10.41 8 977784 3343 109608164
Uveitis 11.15 10.41 261 977531 21449 109590058
Quadriplegia 11.14 10.41 12 977780 4115 109607392
Radiation inflammation 11.14 10.41 27 977765 1021 109610486
Secondary immunodeficiency 11.14 10.41 15 977777 4661 109606846
Cerebral toxoplasmosis 11.13 10.41 7 977785 3135 109608372
Arteriosclerosis 11.13 10.41 153 977639 24614 109586893
Facial paralysis 11.09 10.41 149 977643 24065 109587442
Induced labour 11.08 10.41 25 977767 902 109610605
Loss of libido 11.07 10.41 7 977785 3126 109608381
Joint warmth 11.05 10.41 42 977750 2040 109609467
Fear of injection 11.03 10.41 124 977668 8787 109602720
Post procedural haemorrhage 11.01 10.41 86 977706 15426 109596081
Antipsychotic drug level increased 10.98 10.41 29 977763 6986 109604521
Macrocytosis 10.97 10.41 58 977734 3249 109608258
Scedosporium infection 10.96 10.41 4 977788 2454 109609053
Stoma site irritation 10.96 10.41 15 977777 360 109611147
Delayed recovery from anaesthesia 10.96 10.41 3 977789 2212 109609295
Deep vein thrombosis 10.96 10.41 1076 976716 138811 109472696
Nail injury 10.94 10.41 23 977769 790 109610717
Prerenal failure 10.93 10.41 14 977778 4445 109607062
Cyst rupture 10.91 10.41 24 977768 851 109610656
Peripheral motor neuropathy 10.90 10.41 12 977780 4074 109607433
Drug withdrawal convulsions 10.90 10.41 4 977788 2445 109609062
Haemorrhage in pregnancy 10.88 10.41 36 977756 1632 109609875
Tongue oedema 10.86 10.41 37 977755 8219 109603288
Blood test abnormal 10.85 10.41 330 977462 28224 109583283
Injection site haemorrhage 10.81 10.41 375 977417 32653 109578854
Needle fatigue 10.80 10.41 30 977762 1234 109610273
Delirium 10.80 10.41 1037 976755 133988 109477519
Parvovirus B19 infection 10.80 10.41 6 977786 2875 109608632
Oral candidiasis 10.80 10.41 307 977485 44453 109567054
Hip surgery 10.80 10.41 68 977724 4062 109607445
Prothrombin time prolonged 10.77 10.41 99 977693 17162 109594345
Disseminated cryptococcosis 10.76 10.41 5 977787 2652 109608855
Taste disorder 10.73 10.41 693 977099 64694 109546813
Conduction disorder 10.72 10.41 12 977780 4043 109607464
Bronchial obstruction 10.72 10.41 7 977785 3072 109608435
Metastases to meninges 10.71 10.41 18 977774 5110 109606397
Hemianopia 10.71 10.41 6 977786 2862 109608645
Mitral valve incompetence 10.68 10.41 219 977573 33110 109578397
Transient aphasia 10.66 10.41 21 977771 688 109610819
Heart sounds 10.64 10.41 28 977764 1115 109610392
Vitamin B6 deficiency 10.64 10.41 19 977773 577 109610930
Premature delivery 10.59 10.41 350 977442 30282 109581225
Liver function test increased 10.57 10.41 915 976877 87633 109523874
Supraventricular tachycardia 10.57 10.41 152 977640 24270 109587237
Hypoproteinaemia 10.55 10.41 23 977769 5922 109605585
Limb injury 10.55 10.41 420 977372 37216 109574291
Large intestine perforation 10.54 10.41 95 977697 16534 109594973
Central nervous system mass 10.54 10.41 23 977769 811 109610696
Skin abrasion 10.52 10.41 201 977591 15950 109595557
Osteoporotic fracture 10.50 10.41 82 977710 5255 109606252
Skin laceration 10.50 10.41 381 977411 33372 109578135
Cervical incompetence 10.49 10.41 18 977774 529 109610978
Hepatitis A antibody abnormal 10.49 10.41 9 977783 124 109611383
Differentiation syndrome 10.49 10.41 7 977785 3037 109608470
Ischaemic cardiomyopathy 10.47 10.41 36 977756 7975 109603532
Hyperleukocytosis 10.45 10.41 9 977783 3430 109608077
Vascular rupture 10.44 10.41 38 977754 1808 109609699
Vascular pseudoaneurysm 10.43 10.41 13 977779 4177 109607330
Brain death 10.42 10.41 27 977765 6546 109604961
Precancerous skin lesion 10.42 10.41 35 977757 1599 109609908
Wall motion score index abnormal 10.41 10.41 23 977769 818 109610689

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B03AE01 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in other combinations
ATC B03BA01 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
VITAMIN B12 AND FOLIC ACID
Vitamin B12 (cyanocobalamin and analogues)
ATC B03BA51 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
VITAMIN B12 AND FOLIC ACID
Vitamin B12 (cyanocobalamin and analogues)
FDA CS M0022794 Vitamin B 12
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
MeSH PA D018977 Micronutrients
FDA EPC N0000175951 Vitamin B12
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:50646 bone density conservation agent
CHEBI has role CHEBI:50748 antipsoriatic
CHEBI has role CHEBI:63726 neuroprotective agent
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:77715 nasal decongestant
CHEBI has role CHEBI:145947 antiatherosclerotic agent
CHEBI has role CHEBI:231911 renoprotective agent

Related Drugs by ATC class:

B03AE Iron in other combinations 2 drugs
folic acidiron
B03BA Vitamin B12 (cyanocobalamin and analogues) 3 drugs
cobamamidehydroxocobalaminmecobalamin

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Pernicious anemia indication 84027009 DOID:13381
Megaloblastic anemia due to folate deficiency indication 85649008 DOID:14026
Vitamin deficiency indication 85670002
Iron deficiency anemia indication 87522002
Cobalamin deficiency indication 190634004
Prevention of Vitamin B12 Deficiency indication
Vitamin Deficiency Prevention indication
Homocystinuria off-label use 11282001 DOID:9263
Methylmalonic acidemia off-label use 42393006
Homocystinemia off-label use 52311001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;30MCG/ML MULTIPLE VITAMINS INJECTION ADULT APOTEX A210672 April 9, 2026 RX SOLUTION INTRAVENOUS Dec. 1, 2026 COMPETITIVE GENERIC THERAPY
80MG/VIAL;0.02MG/VIAL;400 IU/VIAL;0.001MG/VIAL;5MG/VIAL;0.14MG/VIAL;17MG/VIAL;1MG/VIAL;1.4MG/VIAL;1.2MG/VIAL;7 IU/VIAL;2,300 IU/VIAL;0.2MG/VIAL MULTIPLE VITAMINS INJECTION PEDIATRIC APOTEX A210671 April 21, 2026 RX INJECTABLE INTRAVENOUS Dec. 21, 2026 COMPETITIVE GENERIC THERAPY

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Methionine synthase Enzyme WOMBAT-PK
Methionine synthase reductase Enzyme WOMBAT-PK
Protein amnionless Membrane receptor WOMBAT-PK
Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial Enzyme WOMBAT-PK
Methylmalonic aciduria type A protein, mitochondrial Enzyme WOMBAT-PK
Transcobalamin-2 Secreted WOMBAT-PK
Transcobalamin-1 Secreted WOMBAT-PK

External reference:

IDSource
4021085 VUID
N0000148543 NUI
D00166 KEGG_DRUG
4017441 VANDF
4017907 VANDF
4021085 VANDF
4021896 VANDF
C0042845 UMLSCUI
CHEBI:17439 CHEBI
CNC PDB_CHEM_ID
CHEMBL2110563 ChEMBL_ID
CHEMBL2375172 ChEMBL_ID
DB00115 DRUGBANK_ID
1369 INN_ID
P6YC3EG204 UNII
166596686 PUBCHEM_CID
11248 RXNORM
213062 MMSL
257021 MMSL
4514 MMSL
5682 MMSL
6832 MMSL
6837 MMSL
8312 MMSL
d00413 MMSL
001043 NDDF
30010009 SNOMEDCT_US
304111003 SNOMEDCT_US
419382002 SNOMEDCT_US
D014805 MESH_DESCRIPTOR_UI
P6YC3EG204 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9619 INJECTION 1000 ug INTRAMUSCULAR ANDA 21 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9620 INJECTION 1000 ug INTRAMUSCULAR ANDA 21 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9621 INJECTION 1000 ug INTRAMUSCULAR ANDA 21 sections
Ferralet 90 HUMAN PRESCRIPTION DRUG LABEL 5 0178-0089 TABLET, FILM COATED 12 ug ORAL unapproved drug other 17 sections
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 12 ug ORAL Unapproved drug other 12 sections
CYANOCOBALAMIN HUMAN PRESCRIPTION DRUG LABEL 1 0404-9783 INJECTION, SOLUTION 1000 ug INTRAMUSCULAR ANDA 12 sections
CYANOCOBALAMIN HUMAN PRESCRIPTION DRUG LABEL 1 0404-9783 INJECTION, SOLUTION 1000 ug INTRAMUSCULAR ANDA 12 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0404-9786 INJECTION, SOLUTION 1000 ug INTRAMUSCULAR ANDA 11 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0517-0031 INJECTION, SOLUTION 1000 ug INTRAMUSCULAR ANDA 19 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0517-0032 INJECTION, SOLUTION 1000 ug INTRAMUSCULAR ANDA 19 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0517-0130 INJECTION, SOLUTION 1000 ug INTRAMUSCULAR ANDA 19 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 0.01 mg ORAL unapproved drug other 14 sections
Vitafol OBCaplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 12 ug ORAL unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 12 ug ORAL UNAPPROVED DRUG OTHER 13 sections
VitafolUltra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 12 ug ORAL unapproved drug other 13 sections
Strovite OneCaplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 50 ug ORAL unapproved drug other 14 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 16 0642-3010 CAPSULE, GELATIN COATED 0.01 mg ORAL unapproved drug other 7 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 25 ug ORAL unapproved drug other 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 12 ug ORAL UNAPPROVED DRUG OTHER 4 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 50 ug ORAL UNAPPROVED DRUG OTHER 10 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 16 0813-0202 TABLET 12 ug ORAL UNAPPROVED DRUG OTHER 6 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 10544-549 TABLET, FILM COATED 12 ug ORAL unapproved drug other 8 sections
PRENATAL PLUS IRON HUMAN PRESCRIPTION DRUG LABEL 15 10544-609 TABLET, FILM COATED 12 ug ORAL UNAPPROVED DRUG OTHER 7 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 12 ug ORAL unapproved drug other 15 sections
Se-Natal 19 Chewable HUMAN PRESCRIPTION DRUG LABEL 14 13925-117 TABLET, CHEWABLE 12 ug ORAL unapproved drug other 16 sections
Se-Tan PLUS HUMAN PRESCRIPTION DRUG LABEL 13 13925-118 CAPSULE, GELATIN COATED 15 ug ORAL unapproved drug other 18 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-100 LIQUID 2 ug ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-101 LIQUID 3 ug ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora FE Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 14 15370-102 LIQUID 2 ug ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-103 TABLET, CHEWABLE 4 ug ORAL UNAPPROVED DRUG OTHER 12 sections