cyanocobalamin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4196 68-19-9

Description:

MoleculeDescription

Synonyms:

  • cyanocobalamin
  • vitamin B12
  • cobamin
  • cyanocobalamine
  • Molecular weight: 1355.39
  • Formula: C63H88CoN14O14P
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 512.50
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
70 mcg N
1 mg O
20 mcg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 12.50 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.42 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Sept. 15, 1949 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 922.89 9.91 88 397336 145832 46142806
Pemphigus 641.63 9.91 1279 396145 43995 46244643
Toxicity to various agents 634.58 9.91 523 396901 211243 46077395
Rheumatoid arthritis 633.13 9.91 3847 393577 236368 46052270
Systemic lupus erythematosus 545.76 9.91 1498 395926 63682 46224956
Glossodynia 429.77 9.91 1077 396347 43296 46245342
Drug abuse 401.25 9.91 38 397386 63370 46225268
Drug interaction 346.24 9.91 759 396665 202335 46086303
Intentional overdose 330.32 9.91 74 397350 64870 46223768
Alopecia 302.56 9.91 2391 395033 160023 46128615
Hand deformity 298.62 9.91 804 396620 33770 46254868
Abdominal discomfort 278.01 9.91 2219 395205 148946 46139692
Death 278.00 9.91 1696 395728 333852 45954786
Arthropathy 255.93 9.91 1408 396016 83292 46205346
Drug hypersensitivity 255.41 9.91 1137 396287 242688 46045950
Overdose 251.89 9.91 298 397126 101681 46186957
Pain 245.90 9.91 5544 391880 471404 45817234
Maternal exposure during pregnancy 245.45 9.91 1604 395820 100945 46187693
Arthralgia 230.64 9.91 4369 393055 360234 45928404
Infusion related reaction 224.20 9.91 1553 395871 99655 46188983
Suicide attempt 218.92 9.91 97 397327 54939 46233699
Nasopharyngitis 204.08 9.91 2106 395318 151892 46136746
Joint swelling 195.93 9.91 2219 395205 163854 46124784
Cardiac arrest 184.40 9.91 303 397121 90096 46198542
Wound 182.87 9.91 786 396638 42016 46246622
Acute kidney injury 182.28 9.91 1217 396207 234638 46054000
Febrile neutropenia 175.14 9.91 337 397087 94290 46194348
Fatigue 150.90 9.91 6472 390952 602225 45686413
Anti-cyclic citrullinated peptide antibody positive 138.76 9.91 418 397006 18727 46269911
Exposure during pregnancy 135.32 9.91 1463 395961 106749 46181889
Drug reaction with eosinophilia and systemic symptoms 130.88 9.91 44 397380 29504 46259134
Pericarditis 126.77 9.91 470 396954 23457 46265181
Synovitis 126.32 9.91 922 396502 60153 46228485
Swelling 126.30 9.91 1617 395807 122894 46165744
Cardio-respiratory arrest 124.57 9.91 198 397226 59671 46228967
Electrocardiogram QT prolonged 124.53 9.91 152 397272 51173 46237465
Malignant neoplasm progression 116.85 9.91 235 397189 64691 46223947
Lactic acidosis 115.36 9.91 73 397351 33836 46254802
Respiratory arrest 114.77 9.91 73 397351 33743 46254895
Hyponatraemia 114.23 9.91 459 396965 100873 46187765
Hip arthroplasty 113.43 9.91 376 397048 17736 46270902
Rheumatoid factor positive 112.68 9.91 407 397017 20054 46268584
Depressed level of consciousness 112.14 9.91 144 397280 47425 46241213
Cardiac failure 111.86 9.91 330 397094 79618 46209020
Injection site erythema 109.70 9.91 1041 396383 73386 46215252
Device expulsion 108.79 9.91 49 397375 27493 46261145
Knee arthroplasty 107.62 9.91 443 396981 23222 46265416
Musculoskeletal stiffness 105.94 9.91 1288 396136 96705 46191933
Injection site pain 105.88 9.91 1385 396039 105767 46182871
Bradycardia 102.21 9.91 261 397163 66037 46222601
Rhabdomyolysis 100.73 9.91 125 397299 41784 46246854
Product use issue 98.86 9.91 1236 396188 93408 46195230
Intentional self-injury 98.62 9.91 41 397383 24125 46264513
Sickle cell anaemia with crisis 96.49 9.91 143 397281 3849 46284789
Red blood cell sedimentation rate abnormal 96.10 9.91 295 397129 13354 46275284
Blood pressure fluctuation 95.14 9.91 511 396913 29937 46258701
Sopor 94.18 9.91 26 397398 19802 46268836
Contraindicated product administered 91.77 9.91 1063 396361 78884 46209754
Discomfort 87.75 9.91 689 396735 45981 46242657
Neutropenia 87.46 9.91 788 396636 142416 46146222
Hypotension 87.32 9.91 1423 396001 231166 46057472
Arthritis 85.63 9.91 1021 396403 76295 46212343
C-reactive protein abnormal 82.82 9.91 380 397044 20890 46267748
Sinusitis 81.28 9.91 1554 395870 128214 46160424
Psoriatic arthropathy 79.14 9.91 556 396868 35823 46252815
Agitation 78.77 9.91 227 397197 55188 46233450
Injection site reaction 78.49 9.91 685 396739 47164 46241474
Renal failure 78.44 9.91 605 396819 112989 46175649
Cholestasis 78.42 9.91 68 397356 26825 46261813
Injection site pruritus 78.20 9.91 593 396831 39150 46249488
Tachycardia 77.33 9.91 513 396911 99109 46189529
Injection site swelling 74.51 9.91 593 396831 39734 46248904
Pregnancy 73.92 9.91 439 396985 26698 46261940
Serotonin syndrome 73.38 9.91 59 397365 24161 46264477
Hepatic failure 72.88 9.91 107 397317 33309 46255329
Coma 70.44 9.91 257 397167 58092 46230546
Hepatocellular injury 68.93 9.91 90 397334 29432 46259206
Metabolic acidosis 67.53 9.91 143 397281 38637 46250001
Hepatic function abnormal 66.82 9.91 119 397305 34302 46254336
Osteoarthritis 66.02 9.91 813 396611 61212 46227426
Disease progression 66.00 9.91 480 396944 90820 46197818
Peripheral swelling 65.81 9.91 1787 395637 156284 46132354
Poisoning 65.26 9.91 19 397405 13975 46274663
Multiple organ dysfunction syndrome 64.92 9.91 224 397200 51486 46237152
Respiratory failure 64.51 9.91 507 396917 94309 46194329
Basal cell carcinoma 64.11 9.91 344 397080 20143 46268495
Oropharyngeal pain 60.12 9.91 926 396498 73242 46215396
Product quality issue 58.34 9.91 136 397288 35512 46253126
Injection site bruising 56.80 9.91 507 396917 35129 46253509
Cytomegalovirus infection 56.49 9.91 43 397381 18101 46270537
Dyspnoea 54.65 9.91 3718 393706 511830 45776808
Pain in extremity 54.03 9.91 2706 394718 255974 46032664
Shock 53.71 9.91 64 397360 21781 46266857
Vomiting 53.71 9.91 3232 394192 449562 45839076
Encephalopathy 53.49 9.91 130 397294 33459 46255179
Delirium 53.26 9.91 152 397272 37076 46251562
Anaphylactic reaction 52.87 9.91 252 397172 52860 46235778
Carotid artery thrombosis 52.30 9.91 46 397378 684 46287954
Psoriasis 51.84 9.91 949 396475 77655 46210983
Pulmonary arterial hypertension 51.82 9.91 88 397336 25840 46262798
Drug resistance 51.76 9.91 43 397381 17325 46271313
Hypoglycaemia 51.72 9.91 262 397162 54087 46234551
Disability assessment scale score increased 51.16 9.91 78 397346 2154 46286484
Drug withdrawal syndrome 51.09 9.91 97 397327 27287 46261351
Product use in unapproved indication 50.70 9.91 507 396917 89766 46198872
Thrombocytopenia 50.61 9.91 765 396659 125816 46162822
Drug dependence 50.34 9.91 57 397367 19844 46268794
Hyperkalaemia 50.25 9.91 241 397183 50468 46238170
Blood creatine phosphokinase increased 50.16 9.91 100 397324 27624 46261014
General physical health deterioration 50.01 9.91 689 396735 115080 46173558
Abortion spontaneous 49.91 9.91 580 396844 43066 46245572
Influenza 49.85 9.91 1051 396373 88219 46200419
Infective pulmonary exacerbation of cystic fibrosis 49.80 9.91 15 397409 10792 46277846
Helicobacter infection 49.70 9.91 215 397209 11521 46277117
Confusional state 49.63 9.91 1011 396413 158881 46129757
Sedation 49.33 9.91 74 397350 22836 46265802
Neurologic neglect syndrome 48.69 9.91 43 397381 643 46287995
Joint effusion 47.96 9.91 216 397208 11779 46276859
Duodenal ulcer perforation 47.56 9.91 170 397254 8332 46280306
Hyperglycaemia 46.72 9.91 148 397276 34923 46253715
Weight increased 46.41 9.91 1775 395649 162698 46125940
Seizure 46.38 9.91 752 396672 122302 46166336
Mydriasis 46.24 9.91 16 397408 10537 46278101
Osteonecrosis of jaw 44.56 9.91 147 397277 34255 46254383
Angioedema 43.80 9.91 179 397245 39163 46249475
Osteoporosis 43.52 9.91 533 396891 40075 46248563
Ejection fraction decreased 42.58 9.91 54 397370 17883 46270755
Joint laxity 42.17 9.91 69 397355 2027 46286611
Caesarean section 41.68 9.91 263 397161 16340 46272298
Contusion 41.63 9.91 1007 396417 86480 46202158
Skin cancer 41.56 9.91 167 397257 8656 46279982
Therapeutic product effect decreased 41.52 9.91 958 396466 81643 46206995
Localised infection 41.27 9.91 345 397079 23456 46265182
Renal impairment 41.21 9.91 419 397005 73953 46214685
Heart rate decreased 41.05 9.91 432 396992 31291 46257347
Respiratory depression 40.81 9.91 24 397400 11576 46277062
Full blood count decreased 40.69 9.91 326 397098 21885 46266753
Palmar-plantar erythrodysaesthesia syndrome 40.33 9.91 70 397354 20381 46268257
Torsade de pointes 40.20 9.91 27 397397 12127 46276511
Cardiac failure congestive 40.00 9.91 545 396879 91205 46197433
Posterior reversible encephalopathy syndrome 39.81 9.91 42 397382 15099 46273539
Myocardial infarction 39.11 9.91 589 396835 96939 46191699
Hypothermia 39.05 9.91 28 397396 12155 46276483
Impaired healing 38.82 9.91 481 396943 36262 46252376
Acute hepatic failure 38.52 9.91 41 397383 14680 46273958
Somnolence 38.41 9.91 1026 396398 155495 46133143
Accidental overdose 38.38 9.91 70 397354 19996 46268642
Ventricular tachycardia 38.31 9.91 53 397371 16914 46271724
Altered state of consciousness 38.26 9.91 89 397335 23259 46265379
Adjustment disorder 38.04 9.91 53 397371 1346 46287292
Neuroleptic malignant syndrome 37.75 9.91 24 397400 11098 46277540
Agranulocytosis 37.63 9.91 83 397341 22102 46266536
Injection site rash 37.56 9.91 247 397177 15566 46273072
Jaundice 37.54 9.91 123 397301 28722 46259916
Herpes zoster 37.53 9.91 798 396626 67074 46221564
Weight decreased 37.47 9.91 2173 395251 208676 46079962
Neck deformity 37.26 9.91 61 397363 1793 46286845
Hypokalaemia 37.25 9.91 526 396898 87498 46201140
Acute generalised exanthematous pustulosis 36.72 9.91 17 397407 9388 46279250
Transplant rejection 36.47 9.91 18 397406 9578 46279060
Leukopenia 36.25 9.91 389 397035 67954 46220684
Emotional distress 35.91 9.91 137 397287 30570 46258068
No adverse event 35.50 9.91 160 397264 34071 46254567
Blood pressure diastolic abnormal 35.33 9.91 126 397298 6168 46282470
Aspartate aminotransferase increased 34.84 9.91 466 396958 78234 46210404
International normalised ratio increased 34.58 9.91 245 397179 46638 46242000
Intentional product misuse 34.41 9.91 247 397177 46881 46241757
Femur fracture 34.35 9.91 473 396951 36524 46252114
Intestinal stenosis 34.22 9.91 70 397354 2451 46286187
Off label use 34.12 9.91 2777 394647 377064 45911574
Hypoxia 33.94 9.91 280 397144 51558 46237080
Alanine aminotransferase increased 33.83 9.91 539 396885 87912 46200726
Asthma 33.31 9.91 563 396861 90979 46197659
Disseminated intravascular coagulation 33.15 9.91 70 397354 18935 46269703
Gamma-glutamyltransferase increased 33.13 9.91 148 397276 31592 46257046
Drug level increased 32.95 9.91 67 397357 18374 46270264
Gastroenteritis viral 32.68 9.91 265 397159 17854 46270784
Respiratory distress 32.61 9.91 150 397274 31766 46256872
Pyrexia 32.56 9.91 2542 394882 346260 45942378
Loss of personal independence in daily activities 32.48 9.91 675 396749 56508 46232130
Blood pressure increased 32.22 9.91 1352 396072 125314 46163324
Lower respiratory tract infection 32.19 9.91 653 396771 54436 46234202
Live birth 32.01 9.91 173 397251 10157 46278481
Pre-eclampsia 32.00 9.91 144 397280 7850 46280788
Pulmonary embolism 31.79 9.91 693 396731 107892 46180746
Maternal drugs affecting foetus 31.43 9.91 111 397313 5407 46283231
Disorientation 31.26 9.91 185 397239 36733 46251905
Unresponsive to stimuli 31.24 9.91 154 397270 32020 46256618
Gestational diabetes 31.15 9.91 133 397291 7086 46281552
Surgery 30.92 9.91 378 397046 28407 46260231
Neck mass 30.89 9.91 79 397345 3214 46285424
Bronchitis 30.89 9.91 1148 396276 104831 46183807
Carpal tunnel syndrome 30.83 9.91 236 397188 15623 46273015
Ascites 30.62 9.91 184 397240 36400 46252238
Anxiety 30.38 9.91 1253 396171 180704 46107934
Anaphylactic shock 30.33 9.91 81 397343 20193 46268445
Premature labour 30.26 9.91 182 397242 11117 46277521
Blood bilirubin increased 30.18 9.91 169 397255 34015 46254623
Malignant melanoma 30.11 9.91 169 397255 10065 46278573
Ventricular septal defect 30.10 9.91 89 397335 3945 46284693
Cerebral haemorrhage 29.78 9.91 132 397292 28239 46260399
Psychotic disorder 29.75 9.91 96 397328 22525 46266113
Metastases to liver 29.48 9.91 78 397346 19507 46269131
Urticaria 29.38 9.91 771 396653 117121 46171517
Syncope 29.22 9.91 674 396750 104129 46184509
Blood alkaline phosphatase increased 29.21 9.91 207 397217 39402 46249236
Coagulopathy 29.14 9.91 72 397352 18427 46270211
Blood pressure systolic abnormal 28.91 9.91 108 397316 5409 46283229
Neurotoxicity 28.87 9.91 45 397379 13672 46274966
Graft versus host disease 28.84 9.91 10 397414 6578 46282060
Juvenile idiopathic arthritis 28.80 9.91 89 397335 4043 46284595
Fall 28.78 9.91 3211 394213 325886 45962752
Haemoglobin decreased 28.76 9.91 1358 396066 127591 46161047
Akathisia 28.52 9.91 15 397409 7699 46280939
Myalgia 28.35 9.91 814 396610 122274 46166364
Arrhythmia 28.24 9.91 177 397247 34664 46253974
Brain oedema 28.15 9.91 39 397385 12439 46276199
Ventricular fibrillation 27.92 9.91 34 397390 11462 46277176
Rheumatoid nodule 27.91 9.91 151 397273 8869 46279769
Diabetic ketoacidosis 27.81 9.91 72 397352 18138 46270500
Toxic skin eruption 27.66 9.91 39 397385 12348 46276290
Forced expiratory volume decreased 27.64 9.91 5 397419 5099 46283539
Metastases to bone 27.54 9.91 68 397356 17408 46271230
Status epilepticus 27.43 9.91 48 397376 13931 46274707
Bone marrow failure 27.11 9.91 145 397279 29524 46259114
Blood pressure systolic increased 27.11 9.91 369 397055 28418 46260220
Red blood cell sedimentation rate increased 26.98 9.91 306 397118 22583 46266055
Blood pressure diastolic decreased 26.81 9.91 210 397214 14001 46274637
Musculoskeletal pain 26.69 9.91 784 396640 69344 46219294
Grip strength decreased 26.58 9.91 144 397280 8462 46280176
Fibromyalgia 26.44 9.91 447 396977 36016 46252622
Cardiogenic shock 26.41 9.91 63 397361 16321 46272317
Rash maculo-papular 26.16 9.91 135 397289 27739 46260899
Small for dates baby 25.97 9.91 79 397345 3558 46285080
Nodule 25.89 9.91 224 397200 15381 46273257
Mental status changes 25.73 9.91 204 397220 37884 46250754
Frequent bowel movements 25.70 9.91 190 397234 12442 46276196
Urinary tract infection 25.52 9.91 2192 395232 218074 46070564
Developmental hip dysplasia 25.49 9.91 42 397382 1241 46287397
Tumour lysis syndrome 25.41 9.91 15 397409 7221 46281417
Foot deformity 25.37 9.91 221 397203 15204 46273434
Suicidal ideation 25.26 9.91 333 397091 56049 46232589
Cystitis 25.10 9.91 502 396922 41739 46246899
Blood glucose increased 24.88 9.91 447 396977 71566 46217072
Red blood cell count decreased 24.79 9.91 403 397021 32220 46256418
Extrapyramidal disorder 24.65 9.91 36 397388 11232 46277406
Inappropriate antidiuretic hormone secretion 24.55 9.91 52 397372 14050 46274588
Miosis 24.53 9.91 13 397411 6644 46281994
Cholecystitis chronic 24.51 9.91 32 397392 10467 46278171
Acute myeloid leukaemia 24.39 9.91 62 397362 15716 46272922
Arthritis infective 24.26 9.91 97 397327 5016 46283622
Thrombotic microangiopathy 24.22 9.91 21 397403 8285 46280353
Pancreatitis acute 24.17 9.91 119 397305 24753 46263885
Pleural effusion 24.10 9.91 530 396894 82422 46206216
Foot fracture 24.09 9.91 264 397160 19318 46269320
Tachypnoea 24.09 9.91 54 397370 14297 46274341
Cyst 24.05 9.91 181 397243 11919 46276719
Face oedema 24.01 9.91 83 397341 19070 46269568
Abnormal behaviour 23.95 9.91 95 397329 20963 46267675
Drug-induced liver injury 23.73 9.91 123 397301 25245 46263393
Injury 23.58 9.91 250 397174 43777 46244861
Vitamin B12 deficiency 23.50 9.91 81 397343 3898 46284740
Asphyxia 23.46 9.91 8 397416 5318 46283320
Schizophrenia 23.40 9.91 23 397401 8545 46280093
Smear cervix abnormal 23.23 9.91 60 397364 2456 46286182
Upper respiratory tract infection 23.23 9.91 707 396717 62849 46225789
Sinus tachycardia 23.17 9.91 100 397324 21549 46267089
Cellulitis 23.10 9.91 772 396652 69516 46219122
Product dose omission issue 23.09 9.91 1699 395725 166821 46121817
Limb deformity 23.07 9.91 75 397349 3501 46285137
Skin papilloma 22.93 9.91 83 397341 4093 46284545
Squamous cell carcinoma 22.79 9.91 129 397295 7707 46280931
Disturbance in attention 22.75 9.91 166 397258 31394 46257244
Ischaemic stroke 22.67 9.91 70 397354 16652 46271986
Eye infection 22.58 9.91 144 397280 8979 46279659
Loss of consciousness 22.41 9.91 726 396698 107512 46181126
Product administration error 22.25 9.91 89 397335 19592 46269046
Postoperative wound infection 22.19 9.91 139 397285 8614 46280024
Therapeutic response decreased 22.17 9.91 502 396922 42643 46245995
Haemophagocytic lymphohistiocytosis 22.09 9.91 23 397401 8319 46280319
Synovial cyst 22.07 9.91 122 397302 7224 46281414
Pancreatitis 22.06 9.91 251 397173 43376 46245262
Injection site warmth 21.97 9.91 196 397228 13576 46275062
Fear 21.71 9.91 68 397356 16104 46272534
Anaemia 21.71 9.91 1878 395546 253901 46034737
Hepatic enzyme increased 21.71 9.91 877 396547 80910 46207728
Nausea 21.69 9.91 5359 392065 682095 45606543
Tooth disorder 21.66 9.91 298 397126 23005 46265633
Unintentional medical device removal 21.57 9.91 6 397418 4547 46284091
Aggression 21.43 9.91 110 397314 22634 46266004
Tuberculosis 21.22 9.91 155 397269 10110 46278528
Stevens-Johnson syndrome 21.21 9.91 114 397310 23183 46265455
Pharyngitis streptococcal 21.17 9.91 134 397290 8334 46280304
Stress cardiomyopathy 21.13 9.91 21 397403 7763 46280875
Restlessness 21.03 9.91 129 397295 25395 46263243
Sepsis 20.94 9.91 945 396479 135069 46153569
Toxic epidermal necrolysis 20.85 9.91 108 397316 22170 46266468
Hyperhidrosis 20.71 9.91 590 396834 88718 46199920
Transplant dysfunction 20.68 9.91 7 397417 4675 46283963
Substance abuse 20.68 9.91 5 397419 4162 46284476
Pathogen resistance 20.67 9.91 13 397411 6047 46282591
Tenosynovitis stenosans 20.66 9.91 49 397375 1900 46286738
Mania 20.60 9.91 38 397386 10808 46277830
Multiple fractures 20.60 9.91 98 397326 5469 46283169
Hallucination 20.59 9.91 300 397124 49651 46238987
Hepatotoxicity 20.29 9.91 127 397297 24882 46263756
Myoclonus 20.23 9.91 59 397365 14293 46274345
Circulatory collapse 20.14 9.91 105 397319 21519 46267119
Inflammation 20.12 9.91 551 396873 48230 46240408
Oral herpes 20.12 9.91 253 397171 19137 46269501
Post procedural infection 20.11 9.91 121 397303 7392 46281246
Skin ulcer 20.05 9.91 388 397036 32070 46256568
Poor venous access 19.87 9.91 130 397294 8178 46280460
Anhedonia 19.81 9.91 36 397388 10299 46278339
Myopathy 19.79 9.91 28 397396 8853 46279785
Rash 19.73 9.91 3386 394038 353126 45935512
Acute graft versus host disease 19.68 9.91 5 397419 4025 46284613
Immunodeficiency 19.63 9.91 184 397240 12922 46275716
Melaena 19.58 9.91 147 397277 27625 46261013
Joint destruction 19.53 9.91 64 397360 3000 46285638
Speech disorder 19.52 9.91 205 397219 35962 46252676
Respiratory disorder 19.48 9.91 144 397280 27156 46261482
Aspergillus infection 19.39 9.91 18 397406 6872 46281766
Benign neoplasm of adrenal gland 19.31 9.91 8 397416 24 46288614
Febrile bone marrow aplasia 19.23 9.91 18 397406 6844 46281794
Product complaint 19.14 9.91 47 397377 12054 46276584
Atrioventricular block complete 19.12 9.91 22 397402 7605 46281033
Device difficult to use 19.10 9.91 24 397400 7980 46280658
Bronchospasm 19.07 9.91 69 397355 15638 46273000
Stress 18.98 9.91 574 396850 50977 46237661
Joint injury 18.82 9.91 248 397176 18961 46269677
Right aortic arch 18.78 9.91 17 397407 263 46288375
Injection site haematoma 18.70 9.91 102 397322 6010 46282628
Eosinophilia 18.64 9.91 92 397332 19125 46269513
Bone erosion 18.62 9.91 141 397283 9302 46279336
Orthostatic hypotension 18.60 9.91 128 397296 24530 46264108
Polyneuropathy 18.59 9.91 45 397379 11599 46277039
Oedema 18.50 9.91 432 396992 66639 46221999
Haematotoxicity 18.49 9.91 19 397405 6914 46281724
Blood pressure diastolic increased 18.48 9.91 100 397324 5874 46282764
Foetal exposure during pregnancy 18.47 9.91 366 397058 30381 46258257
Hypomagnesaemia 18.43 9.91 112 397312 22098 46266540
Erythema multiforme 18.43 9.91 34 397390 9670 46278968
Bronchopulmonary aspergillosis 18.39 9.91 22 397402 7474 46281164
Immunosuppression 18.33 9.91 118 397306 7382 46281256
Obstructive airways disorder 18.29 9.91 56 397368 13356 46275282
Blood iron decreased 18.26 9.91 159 397265 10938 46277700
Diverticulitis 18.11 9.91 388 397036 32651 46255987
Dyspnoea exertional 18.05 9.91 310 397114 49979 46238659
Disability 17.96 9.91 148 397276 10019 46278619
Swollen joint count increased 17.96 9.91 53 397371 2347 46286291
Premature rupture of membranes 17.95 9.91 80 397344 4343 46284295
Tremor 17.89 9.91 803 396621 114836 46173802
Melanocytic naevus 17.87 9.91 73 397351 3812 46284826
Bradyphrenia 17.86 9.91 16 397408 6214 46282424
Hypocalcaemia 17.84 9.91 144 397280 26641 46261997
Neutrophil count decreased 17.83 9.91 261 397163 43165 46245473
Rheumatic fever 17.78 9.91 59 397365 2784 46285854
Sensory loss 17.74 9.91 110 397314 6792 46281846
Catatonia 17.74 9.91 5 397419 3757 46284881
Cytomegalovirus viraemia 17.63 9.91 8 397416 4470 46284168
Anuria 17.61 9.91 45 397379 11386 46277252
Tardive dyskinesia 17.60 9.91 23 397401 7520 46281118
Device dislocation 17.54 9.91 111 397313 21691 46266947
Bone density abnormal 17.53 9.91 62 397362 3022 46285616
Pulmonary hypertension 17.46 9.91 209 397215 35784 46252854
Haemoptysis 17.35 9.91 141 397283 26048 46262590
Wheezing 17.31 9.91 335 397089 53051 46235587
Device use error 17.19 9.91 11 397413 5070 46283568
Blood creatinine increased 17.14 9.91 507 396917 75896 46212742
Hernia 17.05 9.91 141 397283 9554 46279084
Injection site irritation 16.99 9.91 77 397347 4210 46284428
Knee operation 16.98 9.91 83 397341 4683 46283955
Enthesopathy 16.94 9.91 82 397342 4608 46284030
Sedation complication 16.90 9.91 5 397419 3640 46284998
Nephrolithiasis 16.80 9.91 384 397040 32667 46255971
Parkinsonism 16.80 9.91 26 397398 7922 46280716
Proteinuria 16.79 9.91 78 397346 16475 46272163
Polyhydramnios 16.76 9.91 46 397378 1953 46286685
Renal injury 16.76 9.91 35 397389 9506 46279132
Joint stiffness 16.72 9.91 324 397100 26784 46261854
Complication associated with device 16.72 9.91 71 397353 15370 46273268
Tooth infection 16.69 9.91 169 397255 12117 46276521
Metastases to central nervous system 16.65 9.91 45 397379 11176 46277462
Ear infection 16.64 9.91 282 397142 22731 46265907
Neoplasm progression 16.62 9.91 146 397278 26537 46262101
Faecal calprotectin increased 16.60 9.91 43 397381 1763 46286875
Pulseless electrical activity 16.57 9.91 22 397402 7145 46281493
Latent tuberculosis 16.33 9.91 45 397379 1915 46286723
Atrial septal defect 16.33 9.91 101 397323 6231 46282407
Spinal stenosis 16.31 9.91 171 397253 12372 46276266
Pregnancy with contraceptive device 16.29 9.91 9 397415 4494 46284144
Catheter site pain 16.28 9.91 6 397418 3800 46284838
Hyperthermia 16.20 9.91 27 397397 7987 46280651
Hiatus hernia 16.18 9.91 232 397192 18070 46270568
Injection site haemorrhage 16.17 9.91 257 397167 20452 46268186
Breast feeding 16.11 9.91 28 397396 865 46287773
Acute chest syndrome 16.11 9.91 22 397402 548 46288090
Hallucination, auditory 16.07 9.91 43 397381 10713 46277925
Chest discomfort 16.04 9.91 617 396807 89652 46198986
Rhinorrhoea 16.04 9.91 525 396899 47140 46241498
Coronary artery disease 15.98 9.91 197 397227 33555 46255083
Viral infection 15.91 9.91 353 397071 29882 46258756
Clear cell renal cell carcinoma 15.90 9.91 30 397394 989 46287649
Drug abuser 15.81 9.91 4 397420 3229 46285409
Limb injury 15.76 9.91 240 397184 18934 46269704
Metabolic surgery 15.69 9.91 29 397395 941 46287697
Ketoacidosis 15.67 9.91 7 397417 3948 46284690
Placental disorder 15.56 9.91 36 397388 1373 46287265
Hypomania 15.55 9.91 9 397415 4379 46284259
Intervertebral disc degeneration 15.54 9.91 177 397247 13075 46275563
Foreign body in reproductive tract 15.44 9.91 15 397409 255 46288383
Genital haemorrhage 15.34 9.91 20 397404 6546 46282092
Dry eye 15.32 9.91 352 397072 29970 46258668
Haemorrhage 15.25 9.91 353 397071 54516 46234122
Epilepsy 15.18 9.91 129 397295 23609 46265029
Condition aggravated 15.18 9.91 2342 395082 242710 46045928
Uterine perforation 15.14 9.91 24 397400 7243 46281395
Premature delivery 15.08 9.91 268 397156 21801 46266837
Laryngitis 15.08 9.91 133 397291 9183 46279455
Injection site urticaria 15.03 9.91 162 397262 11805 46276833
Injection site induration 15.03 9.91 119 397305 7960 46280678
Mouth ulceration 14.99 9.91 316 397108 26516 46262122
Skin laceration 14.98 9.91 231 397193 18271 46270367
Synovial fluid analysis 14.98 9.91 35 397389 1344 46287294
Tenderness 14.93 9.91 214 397210 16667 46271971
Congenital arterial malformation 14.92 9.91 17 397407 350 46288288
Therapeutic reaction time decreased 14.91 9.91 30 397394 1038 46287600
Serum ferritin increased 14.73 9.91 86 397338 5197 46283441
Pemphigoid 14.72 9.91 16 397408 5675 46282963
Soft tissue mass 14.71 9.91 15 397409 271 46288367
Blood iron increased 14.69 9.91 34 397390 1297 46287341
Increased tendency to bruise 14.69 9.91 134 397290 9340 46279298
Ingrown hair 14.67 9.91 19 397405 449 46288189
Dystonia 14.65 9.91 48 397376 11209 46277429
Intestinal resection 14.59 9.91 47 397377 2183 46286455
Septic shock 14.57 9.91 378 397046 57515 46231123
Cytokine release syndrome 14.49 9.91 19 397405 6204 46282434
Incorrect route of product administration 14.46 9.91 81 397343 16302 46272336
Wheelchair user 14.43 9.91 70 397354 3938 46284700
Burning sensation 14.39 9.91 487 396937 43924 46244714
Metastases to lung 14.34 9.91 45 397379 10651 46277987
Acidosis 14.29 9.91 48 397376 11126 46277512
Polyarthritis 14.23 9.91 100 397324 6442 46282196
Abortion incomplete 14.21 9.91 5 397419 3259 46285379
Cardiotoxicity 14.19 9.91 22 397402 6700 46281938
Accidental exposure to product 14.19 9.91 113 397311 20968 46267670
Breast cancer metastatic 14.14 9.91 64 397360 13614 46275024
Hypertransaminasaemia 14.10 9.91 6 397418 3482 46285156
Pulmonary alveolar haemorrhage 14.10 9.91 9 397415 4153 46284485
Cyanosis 14.07 9.91 79 397345 15892 46272746
Viral upper respiratory tract infection 13.96 9.91 105 397319 6913 46281725
Loose body in joint 13.96 9.91 29 397395 1027 46287611
Interstitial lung disease 13.91 9.91 351 397073 53598 46235040
Fracture 13.86 9.91 207 397217 16264 46272374
Rectal abscess 13.85 9.91 28 397396 972 46287666
Pulmonary tuberculosis 13.83 9.91 78 397346 4653 46283985
Dermatitis exfoliative 13.78 9.91 17 397407 5699 46282939
Arthropod bite 13.73 9.91 91 397333 5750 46282888
Cataract 13.72 9.91 494 396930 44921 46243717
Hyperprolactinaemia 13.64 9.91 4 397420 2928 46285710
Cerebral infarction 13.62 9.91 130 397294 23236 46265402
Scleritis 13.62 9.91 55 397369 2857 46285781
Antibody test positive 13.60 9.91 45 397379 2120 46286518
Vitamin B12 decreased 13.45 9.91 53 397371 2722 46285916
Acute respiratory failure 13.45 9.91 171 397253 28967 46259671
Synovial disorder 13.40 9.91 25 397399 817 46287821
Cardiomyopathy 13.36 9.91 81 397343 15992 46272646
Kidney infection 13.36 9.91 209 397215 16580 46272058
Wrong product administered 13.31 9.91 17 397407 5613 46283025
Pain in jaw 13.30 9.91 238 397186 38134 46250504
Shock haemorrhagic 13.24 9.91 34 397390 8590 46280048
Cervical incompetence 13.20 9.91 21 397403 602 46288036
Joint noise 13.20 9.91 58 397366 3129 46285509
Body height below normal 13.18 9.91 40 397384 1799 46286839
Liver injury 13.12 9.91 81 397343 15920 46272718
Oliguria 13.09 9.91 35 397389 8724 46279914
Hepatitis cholestatic 13.03 9.91 23 397401 6654 46281984
Morning sickness 13.02 9.91 22 397402 664 46287974
Hepatocellular carcinoma 12.97 9.91 4 397420 2835 46285803
Medication error 12.97 9.91 185 397239 30726 46257912
Hypoglycaemic coma 12.95 9.91 3 397421 2571 46286067
Deep vein thrombosis 12.94 9.91 551 396873 79222 46209416
Product substitution issue 12.89 9.91 75 397349 14956 46273682
Gestational hypertension 12.84 9.91 44 397380 2111 46286527
Haematocrit decreased 12.81 9.91 390 397034 34667 46253971
Pulmonary oedema 12.78 9.91 334 397090 50771 46237867
Foetal distress syndrome 12.74 9.91 31 397393 1222 46287416
Acute myocardial infarction 12.72 9.91 193 397231 31731 46256907
Osteonecrosis 12.67 9.91 149 397275 25595 46263043
Cartilage injury 12.65 9.91 36 397388 1561 46287077
Intentional product use issue 12.65 9.91 560 396864 52220 46236418
Purging 12.64 9.91 7 397417 46 46288592
Exomphalos 12.59 9.91 19 397405 520 46288118
Hyperuricaemia 12.49 9.91 13 397411 4704 46283934
Pseudomonas infection 12.43 9.91 42 397382 9716 46278922
Acute coronary syndrome 12.27 9.91 45 397379 10159 46278479
Body temperature decreased 12.27 9.91 171 397253 13238 46275400
Labelled drug-drug interaction medication error 12.23 9.91 38 397386 9023 46279615
Tonsillar inflammation 12.23 9.91 9 397415 102 46288536
Trichoglossia 12.22 9.91 10 397414 134 46288504
Pulmonary haemorrhage 12.17 9.91 23 397401 6482 46282156
Chronic graft versus host disease 12.17 9.91 4 397420 2721 46285917
Thyroid function test abnormal 12.16 9.91 57 397367 3161 46285477
Hepatic necrosis 12.15 9.91 18 397406 5583 46283055
Joint lock 12.09 9.91 42 397382 2029 46286609
Skin discolouration 12.06 9.91 364 397060 32316 46256322
Alcohol interaction 12.00 9.91 3 397421 2442 46286196
Drug ineffective 11.97 9.91 6143 391281 671695 45616943
Acute respiratory distress syndrome 11.93 9.91 124 397300 21798 46266840
Joint range of motion decreased 11.93 9.91 188 397236 14936 46273702
Hyperbilirubinaemia 11.93 9.91 47 397377 10391 46278247
Upper limb fracture 11.90 9.91 194 397230 15519 46273119
Carcinoma in situ of skin 11.89 9.91 12 397412 214 46288424
Renal mass 11.86 9.91 38 397386 1760 46286878
Dermatitis bullous 11.84 9.91 30 397394 7613 46281025
Treatment failure 11.82 9.91 933 396491 92154 46196484
Atrial fibrillation 11.75 9.91 742 396682 102848 46185790
Creatinine renal clearance decreased 11.64 9.91 26 397398 6894 46281744
Bundle branch block left 11.64 9.91 23 397401 6376 46282262
Cholestasis of pregnancy 11.63 9.91 28 397396 1096 46287542
Nightmare 11.63 9.91 88 397336 16510 46272128
Complication of device insertion 11.61 9.91 15 397409 4929 46283709
Induced labour 11.59 9.91 25 397399 909 46287729
Cystitis haemorrhagic 11.57 9.91 8 397416 3539 46285099
Colitis microscopic 11.56 9.91 24 397400 6532 46282106
Arthritis bacterial 11.51 9.91 86 397338 5650 46282988
Aspiration 11.48 9.91 42 397382 9489 46279149
Body temperature fluctuation 11.46 9.91 38 397386 1792 46286846
Talipes 11.43 9.91 32 397392 1375 46287263
Hyperammonaemia 11.40 9.91 14 397410 4702 46283936
Coronary arterial stent insertion 11.39 9.91 5 397419 2848 46285790
Sudden death 11.37 9.91 42 397382 9462 46279176
Electrocardiogram QRS complex prolonged 11.35 9.91 18 397406 5431 46283207
Renal tubular necrosis 11.33 9.91 50 397374 10709 46277929
Red blood cell count 11.32 9.91 3 397421 0 46288638
Vasa praevia 11.32 9.91 3 397421 0 46288638
Shigella infection 11.32 9.91 3 397421 0 46288638
Angina pectoris 11.32 9.91 160 397264 26615 46262023
Kidney transplant rejection 11.31 9.91 11 397413 4107 46284531
Leukocytosis 11.29 9.91 136 397288 23262 46265376
Rotator cuff repair 11.28 9.91 33 397391 1454 46287184
Respiratory acidosis 11.27 9.91 22 397402 6126 46282512
Wrong technique in product usage process 11.26 9.91 365 397059 54057 46234581
Hepatitis C 11.25 9.91 23 397401 6295 46282343
Bone disorder 11.22 9.91 236 397188 19797 46268841
Mean cell volume increased 11.21 9.91 51 397373 2793 46285845
Sinus congestion 11.13 9.91 165 397259 12944 46275694
Bite 11.12 9.91 15 397409 369 46288269
Animal bite 11.03 9.91 44 397380 2273 46286365
Mycobacterium tuberculosis complex test positive 11.01 9.91 34 397390 1544 46287094
Naevus flammeus 10.97 9.91 9 397415 121 46288517
Large intestinal stenosis 10.95 9.91 37 397387 1762 46286876
Bundle branch block right 10.93 9.91 15 397409 4804 46283834
Bladder disorder 10.92 9.91 100 397324 6978 46281660
Fracture delayed union 10.84 9.91 42 397382 2140 46286498
Spinal osteoarthritis 10.82 9.91 175 397249 13976 46274662
Myocardial ischaemia 10.73 9.91 64 397360 12685 46275953
Gastrointestinal inflammation 10.71 9.91 68 397356 4233 46284405
Chondropathy 10.69 9.91 39 397385 1931 46286707
Hepatitis fulminant 10.67 9.91 8 397416 3394 46285244
Angina unstable 10.66 9.91 31 397393 7517 46281121
Haemorrhage intracranial 10.64 9.91 64 397360 12660 46275978
Gait disturbance 10.64 9.91 1402 396022 143861 46144777
Human antichimeric antibody positive 10.61 9.91 31 397393 1365 46287273
Hallucination, visual 10.61 9.91 99 397325 17774 46270864
Tubulointerstitial nephritis 10.55 9.91 78 397346 14710 46273928
Foetal anticonvulsant syndrome 10.54 9.91 16 397408 440 46288198
Catheter site erythema 10.52 9.91 11 397413 3972 46284666
Joint warmth 10.47 9.91 29 397395 1238 46287400
Muscle rupture 10.47 9.91 40 397384 2025 46286613
Neutropenic colitis 10.46 9.91 3 397421 2229 46286409
Fluid retention 10.41 9.91 343 397081 50703 46237935
Temperature regulation disorder 10.41 9.91 8 397416 3352 46285286
Spondylitis 10.41 9.91 39 397385 1956 46286682
Blood folate increased 10.39 9.91 9 397415 131 46288507
Atrioventricular block 10.35 9.91 27 397397 6784 46281854
Complication of pregnancy 10.33 9.91 17 397407 502 46288136
Diabetes mellitus 10.31 9.91 336 397088 49729 46238909
Pulmonary toxicity 10.26 9.91 15 397409 4678 46283960
Decreased appetite 10.24 9.91 1470 395954 192366 46096272
Hospitalisation 10.24 9.91 438 396986 62947 46225691
Squamous cell carcinoma of skin 10.23 9.91 77 397347 5070 46283568
Lupus-like syndrome 10.23 9.91 107 397317 7737 46280901
Lung neoplasm malignant 10.20 9.91 187 397237 15302 46273336
Neck pain 10.18 9.91 572 396852 54734 46233904
Potentiating drug interaction 10.18 9.91 11 397413 3912 46284726
Skin infection 10.13 9.91 144 397280 11195 46277443
Paranoia 10.13 9.91 51 397373 10546 46278092
Endodontic procedure 10.12 9.91 45 397379 2440 46286198
Treatment noncompliance 10.12 9.91 185 397239 29546 46259092
Anterior chamber cleavage syndrome 10.11 9.91 10 397414 174 46288464
Personality disorder 10.07 9.91 53 397371 3080 46285558
Diabetes insipidus 10.05 9.91 3 397421 2171 46286467
Intervertebral disc protrusion 10.04 9.91 236 397188 20169 46268469
Injection site extravasation 10.03 9.91 95 397329 6690 46281948
Therapy interrupted 10.03 9.91 138 397286 10653 46277985
Acute pulmonary oedema 10.02 9.91 34 397390 7857 46280781
Liver transplant 10.02 9.91 4 397420 2413 46286225
Lymphadenectomy 10.01 9.91 23 397401 873 46287765
Hypoaesthesia 9.97 9.91 1157 396267 117712 46170926
Sickle cell anaemia 9.96 9.91 18 397406 574 46288064
Hysterectomy 9.95 9.91 106 397318 7700 46280938

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 391.60 10.24 24 177801 82048 29692605
Toxicity to various agents 355.01 10.24 318 177507 176865 29597788
Completed suicide 332.05 10.24 90 177735 99402 29675251
Rheumatoid arthritis 320.10 10.24 736 177089 40461 29734192
Drug interaction 204.00 10.24 563 177262 199005 29575648
Arthralgia 184.33 10.24 1408 176417 134383 29640270
Foetal exposure during pregnancy 141.34 10.24 511 177314 36360 29738293
Acute kidney injury 113.74 10.24 1059 176766 272783 29501870
Overdose 108.47 10.24 210 177615 84127 29690526
Fatigue 88.41 10.24 2509 175316 318164 29456489
Psoriatic arthropathy 87.37 10.24 248 177577 15513 29759140
Intentional overdose 87.05 10.24 71 177754 41410 29733243
Joint swelling 86.32 10.24 525 177300 46421 29728232
Nasopharyngitis 81.77 10.24 614 177211 58235 29716418
Blood pressure fluctuation 79.70 10.24 257 177568 17246 29757407
Sickle cell anaemia with crisis 77.47 10.24 83 177742 2319 29772334
Coma 74.50 10.24 78 177747 40371 29734282
Drug reaction with eosinophilia and systemic symptoms 74.44 10.24 38 177787 28450 29746203
Enthesopathy 71.03 10.24 87 177738 2819 29771834
Cardiac arrest 64.13 10.24 308 177517 92542 29682111
Suicide attempt 60.84 10.24 77 177748 36620 29738033
Rhabdomyolysis 57.83 10.24 189 177636 63391 29711262
Premature baby 57.02 10.24 223 177602 16468 29758185
Pain 56.67 10.24 1383 176442 171258 29603395
Respiratory arrest 56.65 10.24 54 177771 29204 29745449
Exposure during pregnancy 56.56 10.24 151 177674 9110 29765543
Peripheral swelling 54.71 10.24 579 177246 60495 29714158
Atrial septal defect 53.40 10.24 121 177704 6580 29768073
Haemoglobin decreased 52.71 10.24 961 176864 113137 29661516
Neonatal respiratory distress syndrome 52.15 10.24 89 177736 3923 29770730
Intentional product misuse 51.22 10.24 79 177746 34588 29740065
Full blood count decreased 49.70 10.24 205 177620 15512 29759141
Tenosynovitis 48.38 10.24 80 177745 3435 29771218
Musculoskeletal stiffness 47.37 10.24 370 177455 35511 29739142
Serotonin syndrome 46.54 10.24 24 177801 17867 29756786
Febrile neutropenia 46.10 10.24 408 177417 106285 29668368
Product use in unapproved indication 46.04 10.24 253 177572 73440 29701213
Multiple organ dysfunction syndrome 45.94 10.24 207 177618 63280 29711373
Drug dependence 45.23 10.24 36 177789 21259 29753394
Weight decreased 45.08 10.24 1194 176631 149727 29624926
Sopor 44.94 10.24 6 177819 10985 29763668
Bradycardia 44.27 10.24 219 177606 65307 29709346
Renal failure 43.10 10.24 524 177301 128442 29646211
Skin cancer 42.88 10.24 124 177701 7837 29766816
Pain in extremity 42.36 10.24 903 176922 109318 29665335
Maternal drugs affecting foetus 40.76 10.24 83 177742 4190 29770463
Fall 40.34 10.24 1387 176438 180485 29594168
Cytomegalovirus infection 39.94 10.24 49 177776 23625 29751028
Angioedema 39.65 10.24 91 177734 34293 29740360
Hepatic function abnormal 39.31 10.24 123 177702 41822 29732831
Hypospadias 38.26 10.24 62 177763 2617 29772036
Lactic acidosis 38.14 10.24 80 177745 31133 29743520
Drug resistance 38 10.24 38 177787 20095 29754558
Small for dates baby 37.59 10.24 68 177757 3140 29771513
Maternal exposure during breast feeding 36.91 10.24 47 177778 1585 29773068
Pneumonia 36.69 10.24 2376 175449 331930 29442723
Arthritis 36.39 10.24 259 177566 24142 29750511
Back pain 36.08 10.24 830 176995 101766 29672887
Blood pressure increased 35.37 10.24 612 177213 71316 29703337
Poisoning 34.84 10.24 12 177813 11370 29763283
Hepatic failure 34.67 10.24 96 177729 33947 29740706
Agitation 34.67 10.24 184 177641 53889 29720764
Vitamin B12 deficiency 34.14 10.24 58 177767 2547 29772106
Influenza 33.65 10.24 400 177425 42998 29731655
Maternal exposure during pregnancy 33.21 10.24 72 177753 3799 29770854
Basal cell carcinoma 32.95 10.24 185 177640 15883 29758770
Osteoarthritis 32.94 10.24 204 177621 18145 29756508
Drug intolerance 32.76 10.24 412 177413 44879 29729774
Drug withdrawal syndrome 32.38 10.24 42 177783 19767 29754886
Tongue disorder 32.19 10.24 76 177749 4246 29770407
Cardiac failure 32.18 10.24 328 177497 83090 29691563
Dysmorphism 32.02 10.24 49 177776 1968 29772685
Ventricular septal defect 31.84 10.24 67 177758 3462 29771191
Hypoglycaemia neonatal 31.79 10.24 43 177782 1540 29773113
Asthenia 31.18 10.24 1609 176216 219681 29554972
Suicidal ideation 31.02 10.24 110 177715 36004 29738649
Synovitis 30.45 10.24 127 177698 9656 29764997
Respiratory failure 30.25 10.24 418 177407 100224 29674429
Infusion related reaction 30.19 10.24 371 177454 40193 29734460
Urinary tract infection 30.08 10.24 609 177216 73050 29701603
Psoriasis 30.03 10.24 385 177440 42121 29732532
Blood pressure systolic increased 29.69 10.24 172 177653 14938 29759715
Low birth weight baby 29.29 10.24 91 177734 5985 29768668
Pathogen resistance 29.18 10.24 7 177818 8403 29766250
Hypoglycaemia 28.65 10.24 181 177644 50800 29723853
Arthropathy 28.61 10.24 216 177609 20511 29754142
Syndactyly 28.32 10.24 28 177797 710 29773943
Product dose omission issue 28.20 10.24 728 177097 90903 29683750
Infective pulmonary exacerbation of cystic fibrosis 28.09 10.24 8 177817 8564 29766089
Musculoskeletal pain 27.53 10.24 293 177532 30647 29744006
Depressed level of consciousness 27.41 10.24 125 177700 38097 29736556
Intentional self-injury 27.35 10.24 24 177801 13508 29761145
Immune reconstitution inflammatory syndrome 27.17 10.24 10 177815 9091 29765562
Aggression 26.89 10.24 120 177705 36787 29737866
Joint range of motion decreased 26.76 10.24 86 177739 5759 29768894
Death 26.60 10.24 1796 176029 355487 29419166
Delirium 26.18 10.24 138 177687 40493 29734160
Substance abuse 26.18 10.24 5 177820 7035 29767618
Haemangioma congenital 26.05 10.24 23 177802 503 29774150
Palmar-plantar erythrodysaesthesia syndrome 25.91 10.24 30 177795 14840 29759813
Cryptorchism 25.59 10.24 40 177785 1637 29773016
Back disorder 25.48 10.24 86 177739 5908 29768745
Poor venous access 24.64 10.24 49 177776 2431 29772222
Large for dates baby 24.49 10.24 28 177797 842 29773811
C-reactive protein abnormal 24.44 10.24 81 177744 5512 29769141
Altered state of consciousness 24.38 10.24 51 177774 19868 29754785
Hyperbilirubinaemia neonatal 24.32 10.24 25 177800 665 29773988
Hyperglycaemia 24.14 10.24 117 177708 35083 29739570
Pyrexia 24.01 10.24 1468 176357 293021 29481632
Drug-induced liver injury 23.97 10.24 57 177768 21217 29753436
Injection site pain 23.77 10.24 280 177545 30030 29744623
Renal impairment 23.76 10.24 354 177471 83830 29690823
Foetal anticonvulsant syndrome 23.66 10.24 26 177799 748 29773905
Vitamin B12 decreased 23.55 10.24 30 177795 1012 29773641
Exposure via breast milk 23.30 10.24 37 177788 1535 29773118
Knee arthroplasty 23.25 10.24 80 177745 5550 29769103
Psychotic disorder 23.17 10.24 59 177766 21456 29753197
Cellulitis 22.96 10.24 398 177427 46386 29728267
Lower respiratory tract infection 22.85 10.24 251 177574 26463 29748190
Off label use 22.60 10.24 1230 176595 248060 29526593
Neurotoxicity 22.53 10.24 27 177798 13155 29761498
Cataract 22.43 10.24 213 177612 21622 29753031
Electrocardiogram QT prolonged 22.38 10.24 123 177702 35712 29738941
Sinusitis 22.29 10.24 299 177526 33046 29741607
Agranulocytosis 22.25 10.24 62 177763 21880 29752773
Medical device implantation 21.84 10.24 21 177804 514 29774139
Intestinal stenosis 21.84 10.24 40 177785 1865 29772788
Blood iron decreased 21.83 10.24 63 177762 3977 29770676
Body temperature decreased 21.71 10.24 114 177711 9541 29765112
Pulmonary fibrosis 21.60 10.24 165 177660 15725 29758928
Loss of personal independence in daily activities 21.59 10.24 209 177616 21326 29753327
Acute hepatic failure 21.55 10.24 23 177802 11804 29762849
Post transplant lymphoproliferative disorder 21.45 10.24 3 177822 5303 29769350
Shock 21.43 10.24 67 177758 22792 29751861
Rheumatoid nodule 21.32 10.24 37 177788 1653 29773000
Red blood cell count decreased 21.02 10.24 244 177581 26077 29748576
Neck mass 20.90 10.24 33 177792 1362 29773291
Frequent bowel movements 20.83 10.24 102 177723 8303 29766350
Congenital oesophageal anomaly 20.72 10.24 11 177814 99 29774554
Kidney infection 20.63 10.24 67 177758 4511 29770142
Anaphylactic shock 20.55 10.24 32 177793 13961 29760692
Alanine aminotransferase abnormal 20.54 10.24 47 177778 2572 29772081
Congenital hand malformation 20.38 10.24 19 177806 447 29774206
Blood pressure systolic abnormal 20.34 10.24 34 177791 1473 29773180
Toxic epidermal necrolysis 20.26 10.24 48 177777 17892 29756761
Heart rate decreased 20.19 10.24 202 177623 20792 29753861
Somnolence 19.98 10.24 430 177395 96333 29678320
Sedation 19.97 10.24 42 177783 16331 29758322
Gamma-glutamyltransferase increased 19.86 10.24 98 177727 29252 29745401
Post procedural infection 19.79 10.24 66 177759 4506 29770147
Thrombocytopenia 19.61 10.24 642 177183 136402 29638251
Rash maculo-papular 19.52 10.24 81 177744 25337 29749316
Anal fistula 19.49 10.24 60 177765 3926 29770727
Hypertriglyceridaemia 19.43 10.24 12 177813 8086 29766567
Pancytopenia 19.40 10.24 651 177174 84401 29690252
Faecal calprotectin increased 19.34 10.24 29 177796 1144 29773509
Proteinuria 19.20 10.24 42 177783 16103 29758550
Juvenile idiopathic arthritis 18.95 10.24 27 177798 1016 29773637
Throat lesion 18.93 10.24 10 177815 89 29774564
Hypoaesthesia 18.81 10.24 438 177387 53792 29720861
Osteonecrosis of jaw 18.59 10.24 53 177772 18565 29756088
Venoocclusive liver disease 18.54 10.24 8 177817 6605 29768048
Hepatic encephalopathy 18.52 10.24 35 177790 14157 29760496
Tachycardia 18.49 10.24 317 177508 73422 29701231
Blood creatine phosphokinase increased 18.33 10.24 169 177656 43679 29730974
Asthma 18.05 10.24 133 177692 36041 29738612
Medication error 17.93 10.24 64 177761 20908 29753745
Acute respiratory distress syndrome 17.90 10.24 75 177750 23397 29751256
Cardio-respiratory arrest 17.57 10.24 237 177588 57069 29717584
Ventricular fibrillation 17.50 10.24 40 177785 15098 29759555
Incorrect route of product administration 17.47 10.24 25 177800 11290 29763363
Cytokine release syndrome 17.35 10.24 20 177805 9913 29764740
Hyperkalaemia 17.13 10.24 282 177543 65728 29708925
Bradycardia neonatal 17.07 10.24 24 177801 892 29773761
Neuropathy peripheral 16.73 10.24 542 177283 69933 29704720
Hypokalaemia 16.71 10.24 204 177621 49988 29724665
Hepatocellular injury 16.69 10.24 86 177739 25385 29749268
Localised infection 16.68 10.24 139 177686 13598 29761055
Increased tendency to bruise 16.68 10.24 53 177772 3528 29771125
Blood test abnormal 16.63 10.24 71 177754 5454 29769199
Talipes 16.53 10.24 33 177792 1642 29773011
Agitation neonatal 16.41 10.24 25 177800 1000 29773653
Selective eating disorder 16.41 10.24 33 177792 1651 29773002
Caesarean section 16.38 10.24 38 177787 2099 29772554
Hyperbilirubinaemia 16.35 10.24 49 177776 16893 29757760
Aspergillus infection 16.34 10.24 22 177803 10192 29764461
Balance disorder 16.33 10.24 306 177519 36187 29738466
Injection site erythema 16.28 10.24 139 177686 13695 29760958
Metabolic acidosis 16.27 10.24 143 177682 37318 29737335
Disseminated intravascular coagulation 16.20 10.24 72 177753 22099 29752554
Accidental overdose 16.14 10.24 55 177770 18220 29756433
Tendonitis 16.13 10.24 92 177733 7944 29766709
Vitamin D decreased 16.10 10.24 43 177782 2594 29772059
Intestinal resection 16.05 10.24 30 177795 1421 29773232
Contusion 16.03 10.24 268 177557 31012 29743641
Immunodeficiency 16.01 10.24 59 177766 4235 29770418
Vitamin D deficiency 16 10.24 67 177758 5103 29769550
Ventricular tachycardia 15.96 10.24 80 177745 23782 29750871
Cholestasis 15.93 10.24 85 177740 24865 29749788
Wound 15.87 10.24 127 177698 12275 29762378
Ankylosing spondylitis 15.82 10.24 61 177764 4473 29770180
Vomiting 15.63 10.24 1109 176716 218709 29555944
Arthritis bacterial 15.53 10.24 60 177765 4404 29770249
Lacrimal disorder 15.42 10.24 14 177811 318 29774335
Stevens-Johnson syndrome 15.39 10.24 53 177772 17503 29757150
Injection site bruising 15.38 10.24 85 177740 7253 29767400
Injection site swelling 15.37 10.24 97 177728 8683 29765970
Drug eruption 15.31 10.24 53 177772 17473 29757180
Erythema multiforme 15.15 10.24 15 177810 7970 29766683
Acute graft versus host disease 15.05 10.24 8 177817 5856 29768797
Drug level increased 15.04 10.24 57 177768 18297 29756356
Eosinophilia 14.99 10.24 74 177751 22086 29752567
Brain oedema 14.96 10.24 32 177793 12366 29762287
Product quality issue 14.94 10.24 59 177766 18715 29755938
Hepatitis 14.93 10.24 75 177750 22281 29752372
Nephrolithiasis 14.78 10.24 218 177607 24592 29750061
Hypermobility syndrome 14.74 10.24 12 177813 234 29774419
Infection 14.73 10.24 585 177240 77489 29697164
Status epilepticus 14.71 10.24 27 177798 11045 29763608
Hypotension 14.56 10.24 1010 176815 199555 29575098
Intestinal obstruction 14.41 10.24 176 177649 19036 29755617
Congenital bladder anomaly 14.40 10.24 13 177812 293 29774360
Renal injury 14.38 10.24 30 177795 11699 29762954
Mania 14.36 10.24 20 177805 9134 29765519
Joint stiffness 14.32 10.24 100 177725 9261 29765392
Dermatitis acneiform 14.26 10.24 8 177817 5681 29768972
Finger deformity 14.22 10.24 23 177802 969 29773684
Joint effusion 14.22 10.24 51 177774 3612 29771041
Serum ferritin increased 14.21 10.24 67 177758 5370 29769283
Neck pain 14.07 10.24 188 177637 20756 29753897
Pancreatitis acute 14.04 10.24 92 177733 25603 29749050
Hand deformity 14.02 10.24 33 177792 1840 29772813
Hypoxia 13.92 10.24 200 177625 47654 29726999
Saliva altered 13.84 10.24 10 177815 162 29774491
Speech disorder developmental 13.83 10.24 25 177800 1154 29773499
Jaundice neonatal 13.82 10.24 24 177801 1073 29773580
Akathisia 13.82 10.24 9 177816 5895 29768758
Blood insulin increased 13.81 10.24 14 177811 366 29774287
Neuroleptic malignant syndrome 13.75 10.24 50 177775 16245 29758408
Prostate cancer 13.68 10.24 209 177616 23748 29750905
Multiple congenital abnormalities 13.64 10.24 16 177809 495 29774158
Accessory spleen 13.63 10.24 10 177815 166 29774487
Hepatitis C 13.62 10.24 37 177788 13168 29761485
Diabetic ketoacidosis 13.52 10.24 49 177776 15937 29758716
Pernicious anaemia 13.48 10.24 8 177817 91 29774562
Cleft lip 13.46 10.24 13 177812 320 29774333
Seizure 13.45 10.24 464 177361 98011 29676642
Weight decrease neonatal 13.33 10.24 13 177812 324 29774329
Fistula 13.30 10.24 63 177762 5059 29769594
Acoustic neuroma 13.27 10.24 9 177816 131 29774522
Adverse drug reaction 13.25 10.24 202 177623 22943 29751710
Myocardial infarction 13.25 10.24 610 177215 125015 29649638
Hepatotoxicity 13.21 10.24 59 177766 18086 29756567
Hepatocellular carcinoma 13.16 10.24 23 177802 9587 29765066
Ankyloglossia congenital 13.02 10.24 12 177813 278 29774375
Pulmonary alveolar haemorrhage 12.91 10.24 12 177813 6569 29768084
Grip strength decreased 12.89 10.24 35 177790 2133 29772520
Skin lesion 12.84 10.24 167 177658 18327 29756326
Transaminases increased 12.81 10.24 84 177741 23373 29751280
Polyhydramnios 12.79 10.24 11 177814 232 29774421
Malignant neoplasm progression 12.75 10.24 329 177496 71958 29702695
Squamous cell carcinoma of skin 12.67 10.24 95 177730 9000 29765653
Urticaria 12.66 10.24 238 177587 54368 29720285
Transplant rejection 12.64 10.24 22 177803 9184 29765469
Double stranded DNULL antibody positive 12.63 10.24 8 177817 103 29774550
Foot deformity 12.62 10.24 47 177778 3390 29771263
Nerve compression 12.62 10.24 41 177784 2761 29771892
Folate deficiency 12.61 10.24 22 177803 987 29773666
Vascular insufficiency 12.58 10.24 13 177812 348 29774305
Arthrodesis 12.57 10.24 14 177811 409 29774244
Cerebral microangiopathy 12.50 10.24 10 177815 190 29774463
Exostosis 12.48 10.24 47 177778 3408 29771245
Hypocalcaemia 12.47 10.24 75 177750 21301 29753352
Intervertebral disc protrusion 12.45 10.24 96 177729 9175 29765478
Malignant melanoma 12.44 10.24 81 177744 7330 29767323
Gait apraxia 12.40 10.24 3 177822 0 29774653
Hepatitis fulminant 12.33 10.24 4 177821 3937 29770716
Peripheral artery thrombosis 12.25 10.24 35 177790 2197 29772456
Bronchopulmonary aspergillosis 12.24 10.24 35 177790 12249 29762404
Fear 12.19 10.24 29 177796 10796 29763857
Spinal disorder 12.19 10.24 46 177779 3339 29771314
Acute generalised exanthematous pustulosis 12.10 10.24 11 177814 6087 29768566
Ultrasound skull abnormal 12.07 10.24 7 177818 76 29774577
Neutropenia 12.02 10.24 632 177193 127908 29646745
Hepatic cyst 12.02 10.24 37 177788 2421 29772232
Progressive multifocal leukoencephalopathy 11.96 10.24 22 177803 8991 29765662
Otitis media 11.93 10.24 38 177787 2533 29772120
Haematocrit decreased 11.92 10.24 252 177573 30447 29744206
Foetal disorder 11.91 10.24 17 177808 641 29774012
Endophthalmitis 11.87 10.24 3 177822 3477 29771176
Cytomegalovirus viraemia 11.77 10.24 10 177815 5719 29768934
Magnetic resonance imaging spinal abnormal 11.76 10.24 7 177818 80 29774573
Nocardiosis 11.75 10.24 3 177822 3452 29771201
Excessive cerumen production 11.72 10.24 11 177814 261 29774392
Arthritis infective 11.69 10.24 39 177786 2663 29771990
Septic arthritis staphylococcal 11.69 10.24 14 177811 443 29774210
Blood creatinine increased 11.69 10.24 434 177391 90941 29683712
Tachycardia foetal 11.68 10.24 12 177813 319 29774334
Lipase increased 11.67 10.24 21 177804 8655 29765998
Spinal operation 11.64 10.24 35 177790 2261 29772392
Cystitis haemorrhagic 11.61 10.24 7 177818 4780 29769873
Graft versus host disease 11.59 10.24 27 177798 10123 29764530
Cerebral haemorrhage 11.59 10.24 132 177693 32755 29741898
Foetal growth restriction 11.52 10.24 47 177778 3538 29771115
Chronic graft versus host disease 11.52 10.24 5 177820 4114 29770539
Renal aplasia 11.52 10.24 17 177808 661 29773992
Ileal stenosis 11.51 10.24 23 177802 1145 29773508
Moaning 11.51 10.24 18 177807 737 29773916
Injection site haemorrhage 11.49 10.24 83 177742 7772 29766881
Intellectual disability 11.44 10.24 19 177806 819 29773834
Alcohol abuse 11.43 10.24 9 177816 5344 29769309
Pleural fibrosis 11.42 10.24 26 177799 1418 29773235
Oropharyngeal pain 11.42 10.24 235 177590 28261 29746392
Rheumatoid lung 11.41 10.24 12 177813 328 29774325
Patent ductus arteriosus 11.36 10.24 43 177782 3126 29771527
Tonsil cancer 11.28 10.24 18 177807 750 29773903
Pulmonary arterial hypertension 11.22 10.24 24 177801 9277 29765376
Epstein-Barr virus infection 11.18 10.24 14 177811 6692 29767961
Mydriasis 11.13 10.24 12 177813 6131 29768522
BK virus infection 11.13 10.24 6 177819 4358 29770295
Benign abdominal neoplasm 11.13 10.24 7 177818 89 29774564
Prostatic disorder 11.06 10.24 39 177786 2739 29771914
Umbilical hernia 10.98 10.24 47 177778 3614 29771039
Hernia pain 10.98 10.24 10 177815 228 29774425
Gait disturbance 10.95 10.24 546 177279 74231 29700422
Potentiating drug interaction 10.92 10.24 7 177818 4624 29770029
Thrombosis 10.86 10.24 328 177497 41903 29732750
Hepatitis B 10.85 10.24 12 177813 6060 29768593
Tubulointerstitial nephritis 10.85 10.24 62 177763 17829 29756824
Low set ears 10.84 10.24 13 177812 412 29774241
Cytomegalovirus chorioretinitis 10.80 10.24 3 177822 3265 29771388
Sinus congestion 10.78 10.24 56 177769 4666 29769987
Spinal osteoarthritis 10.78 10.24 70 177755 6329 29768324
Physical examination abnormal 10.74 10.24 7 177818 95 29774558
Maternal exposure timing unspecified 10.73 10.24 12 177813 352 29774301
Adenovirus infection 10.70 10.24 6 177819 4262 29770391
Hip fracture 10.68 10.24 107 177718 11017 29763636
Musculoskeletal discomfort 10.66 10.24 69 177756 6231 29768422
Mouth ulceration 10.65 10.24 103 177722 10506 29764147
Bronchitis 10.64 10.24 306 177519 38819 29735834
Hyperthermia 10.64 10.24 28 177797 10071 29764582
Hepatitis cholestatic 10.64 10.24 19 177806 7853 29766800
Cholelithiasis 10.63 10.24 174 177651 20051 29754602
Platelet count decreased 10.62 10.24 749 177076 105380 29669273
Pulmonary valve stenosis 10.60 10.24 12 177813 357 29774296
Chest expansion decreased 10.60 10.24 8 177817 139 29774514
Respiratory depression 10.58 10.24 34 177791 11469 29763184
Tumour lysis syndrome 10.57 10.24 40 177785 12845 29761808
Anti-erythropoietin antibody positive 10.55 10.24 19 177806 874 29773779
Squamous cell carcinoma 10.53 10.24 100 177725 10150 29764503
Anaemia vitamin B12 deficiency 10.51 10.24 11 177814 299 29774354
Body height decreased 10.49 10.24 47 177778 3687 29770966
Spleen disorder 10.47 10.24 20 177805 963 29773690
Acute graft versus host disease in skin 10.41 10.24 7 177818 4509 29770144
Foetal hypokinesia 10.39 10.24 12 177813 365 29774288
Central nervous system inflammation 10.37 10.24 7 177818 101 29774552
Dairy intolerance 10.34 10.24 3 177822 3 29774650
Anal atresia 10.33 10.24 11 177814 305 29774348
Decreased vibratory sense 10.31 10.24 12 177813 368 29774285
Gastrointestinal infection 10.29 10.24 47 177778 3718 29770935
Suspected suicide 10.27 10.24 3 177822 3158 29771495

Pharmacologic Action:

SourceCodeDescription
ATC B03AE01 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in other combinations
ATC B03BA01 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
VITAMIN B12 AND FOLIC ACID
Vitamin B12 (cyanocobalamin and analogues)
ATC B03BA51 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
VITAMIN B12 AND FOLIC ACID
Vitamin B12 (cyanocobalamin and analogues)
FDA CS M0022794 Vitamin B 12
FDA EPC N0000175951 Vitamin B12
CHEBI has role CHEBI:33229 vitamins

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Pernicious anemia indication 84027009 DOID:13381
Megaloblastic anemia due to folate deficiency indication 85649008 DOID:14026
Vitamin deficiency indication 85670002
Iron deficiency anemia indication 87522002
Cobalamin deficiency indication 190634004
Prevention of Vitamin B12 Deficiency indication
Vitamin Deficiency Prevention indication
Homocystinuria off-label use 11282001 DOID:9263
Methylmalonic acidemia off-label use 42393006
Homocystinemia off-label use 52311001

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Transcobalamin-1 Secreted WOMBAT-PK
Protein amnionless Unclassified WOMBAT-PK
Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial Enzyme WOMBAT-PK
Methylmalonic aciduria type A protein, mitochondrial Enzyme WOMBAT-PK
Transcobalamin-2 Secreted WOMBAT-PK
Methionine synthase reductase Enzyme WOMBAT-PK
Methionine synthase Enzyme WOMBAT-PK

External reference:

IDSource
4021085 VUID
N0000148543 NUI
D00166 KEGG_DRUG
4017441 VANDF
4021085 VANDF
4021896 VANDF
C0042845 UMLSCUI
CHEBI:17439 CHEBI
CHEMBL2110563 ChEMBL_ID
DB00115 DRUGBANK_ID
CHEMBL2375172 ChEMBL_ID
54605677 PUBCHEM_CID
1369 INN_ID
P6YC3EG204 UNII
11248 RXNORM
213062 MMSL
257021 MMSL
4514 MMSL
5682 MMSL
6832 MMSL
6837 MMSL
8312 MMSL
d00413 MMSL
001043 NDDF
30010009 SNOMEDCT_US
419382002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9619 INJECTION 1000 ug INTRAMUSCULAR ANDA 21 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9620 INJECTION 1000 ug INTRAMUSCULAR ANDA 21 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9621 INJECTION 1000 ug INTRAMUSCULAR ANDA 21 sections
Ferralet 90 HUMAN PRESCRIPTION DRUG LABEL 5 0178-0089 TABLET, FILM COATED 12 ug ORAL unapproved drug other 17 sections
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 12 ug ORAL Unapproved drug other 12 sections
CitraNatal Bloom HUMAN PRESCRIPTION DRUG LABEL 6 0178-0813 TABLET, FILM COATED 16.80 ug ORAL unapproved drug other 15 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0517-0031 INJECTION, SOLUTION 1000 ug INTRAMUSCULAR ANDA 19 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0517-0032 INJECTION, SOLUTION 1000 ug INTRAMUSCULAR ANDA 19 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0517-0130 INJECTION, SOLUTION 1000 ug INTRAMUSCULAR ANDA 19 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 0.01 mg ORAL unapproved drug other 7 sections
Vitafol Caplet HUMAN PRESCRIPTION DRUG LABEL 12 0642-0072 CAPSULE 5 ug ORAL UNULLPPROVED DRUG OTHER 13 sections
Vitafol OB Caplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 12 ug ORAL Unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 12 ug ORAL UNULLPPROVED DRUG OTHER 13 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 12 ug ORAL UNULLPPROVED DRUG OTHER 13 sections
Vitafol Nano HUMAN PRESCRIPTION DRUG LABEL 7 0642-0094 TABLET, COATED 12 ug ORAL UNULLPPROVED DRUG OTHER 14 sections
Strovite Forte Caplet HUMAN PRESCRIPTION DRUG LABEL 19 0642-0204 TABLET, COATED 50 ug ORAL UNULLPPROVED DRUG OTHER 15 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 50 ug ORAL UNULLPPROVED DRUG OTHER 14 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 16 0642-3010 CAPSULE, GELATIN COATED 0.01 mg ORAL unapproved drug other 7 sections
Vitafol HUMAN PRESCRIPTION DRUG LABEL 4 0642-7468 STRIP 12 ug ORAL Unapproved drug other 13 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 25 ug ORAL UNULLPPROVED DRUG OTHER 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 12 ug ORAL UNULLPPROVED DRUG OTHER 4 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 50 ug ORAL UNULLPPROVED DRUG OTHER 10 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 16 0813-0202 TABLET 12 ug ORAL UNULLPPROVED DRUG OTHER 6 sections
PRENULLTAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 10544-549 TABLET, FILM COATED 12 ug ORAL unapproved drug other 8 sections
PRENULLTAL PLUS IRON HUMAN PRESCRIPTION DRUG LABEL 15 10544-609 TABLET, FILM COATED 12 ug ORAL UNULLPPROVED DRUG OTHER 7 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 12 ug ORAL unapproved drug other 15 sections
Se-Natal 19 Chewable HUMAN PRESCRIPTION DRUG LABEL 14 13925-117 TABLET, CHEWABLE 12 ug ORAL unapproved drug other 16 sections
Se-Tan PLUS HUMAN PRESCRIPTION DRUG LABEL 13 13925-118 CAPSULE, GELATIN COATED 15 ug ORAL unapproved drug other 19 sections
PRENULLTAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 15338-522 TABLET, FILM COATED 12 ug ORAL unapproved drug other 8 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-100 LIQUID 2 ug ORAL UNULLPPROVED DRUG OTHER 11 sections