Stem definition | Drug id | CAS RN |
---|---|---|
4196 | 68-19-9 |
Molecule | Description |
---|---|
Synonyms:
|
|
Dose | Unit | Route |
---|---|---|
70 | mcg | N |
1 | mg | O |
20 | mcg | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 12.50 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.42 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Date | Agency | Company | Orphan |
---|---|---|---|
Sept. 15, 1949 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 922.89 | 9.91 | 88 | 397336 | 145832 | 46142806 |
Pemphigus | 641.63 | 9.91 | 1279 | 396145 | 43995 | 46244643 |
Toxicity to various agents | 634.58 | 9.91 | 523 | 396901 | 211243 | 46077395 |
Rheumatoid arthritis | 633.13 | 9.91 | 3847 | 393577 | 236368 | 46052270 |
Systemic lupus erythematosus | 545.76 | 9.91 | 1498 | 395926 | 63682 | 46224956 |
Glossodynia | 429.77 | 9.91 | 1077 | 396347 | 43296 | 46245342 |
Drug abuse | 401.25 | 9.91 | 38 | 397386 | 63370 | 46225268 |
Drug interaction | 346.24 | 9.91 | 759 | 396665 | 202335 | 46086303 |
Intentional overdose | 330.32 | 9.91 | 74 | 397350 | 64870 | 46223768 |
Alopecia | 302.56 | 9.91 | 2391 | 395033 | 160023 | 46128615 |
Hand deformity | 298.62 | 9.91 | 804 | 396620 | 33770 | 46254868 |
Abdominal discomfort | 278.01 | 9.91 | 2219 | 395205 | 148946 | 46139692 |
Death | 278.00 | 9.91 | 1696 | 395728 | 333852 | 45954786 |
Arthropathy | 255.93 | 9.91 | 1408 | 396016 | 83292 | 46205346 |
Drug hypersensitivity | 255.41 | 9.91 | 1137 | 396287 | 242688 | 46045950 |
Overdose | 251.89 | 9.91 | 298 | 397126 | 101681 | 46186957 |
Pain | 245.90 | 9.91 | 5544 | 391880 | 471404 | 45817234 |
Maternal exposure during pregnancy | 245.45 | 9.91 | 1604 | 395820 | 100945 | 46187693 |
Arthralgia | 230.64 | 9.91 | 4369 | 393055 | 360234 | 45928404 |
Infusion related reaction | 224.20 | 9.91 | 1553 | 395871 | 99655 | 46188983 |
Suicide attempt | 218.92 | 9.91 | 97 | 397327 | 54939 | 46233699 |
Nasopharyngitis | 204.08 | 9.91 | 2106 | 395318 | 151892 | 46136746 |
Joint swelling | 195.93 | 9.91 | 2219 | 395205 | 163854 | 46124784 |
Cardiac arrest | 184.40 | 9.91 | 303 | 397121 | 90096 | 46198542 |
Wound | 182.87 | 9.91 | 786 | 396638 | 42016 | 46246622 |
Acute kidney injury | 182.28 | 9.91 | 1217 | 396207 | 234638 | 46054000 |
Febrile neutropenia | 175.14 | 9.91 | 337 | 397087 | 94290 | 46194348 |
Fatigue | 150.90 | 9.91 | 6472 | 390952 | 602225 | 45686413 |
Anti-cyclic citrullinated peptide antibody positive | 138.76 | 9.91 | 418 | 397006 | 18727 | 46269911 |
Exposure during pregnancy | 135.32 | 9.91 | 1463 | 395961 | 106749 | 46181889 |
Drug reaction with eosinophilia and systemic symptoms | 130.88 | 9.91 | 44 | 397380 | 29504 | 46259134 |
Pericarditis | 126.77 | 9.91 | 470 | 396954 | 23457 | 46265181 |
Synovitis | 126.32 | 9.91 | 922 | 396502 | 60153 | 46228485 |
Swelling | 126.30 | 9.91 | 1617 | 395807 | 122894 | 46165744 |
Cardio-respiratory arrest | 124.57 | 9.91 | 198 | 397226 | 59671 | 46228967 |
Electrocardiogram QT prolonged | 124.53 | 9.91 | 152 | 397272 | 51173 | 46237465 |
Malignant neoplasm progression | 116.85 | 9.91 | 235 | 397189 | 64691 | 46223947 |
Lactic acidosis | 115.36 | 9.91 | 73 | 397351 | 33836 | 46254802 |
Respiratory arrest | 114.77 | 9.91 | 73 | 397351 | 33743 | 46254895 |
Hyponatraemia | 114.23 | 9.91 | 459 | 396965 | 100873 | 46187765 |
Hip arthroplasty | 113.43 | 9.91 | 376 | 397048 | 17736 | 46270902 |
Rheumatoid factor positive | 112.68 | 9.91 | 407 | 397017 | 20054 | 46268584 |
Depressed level of consciousness | 112.14 | 9.91 | 144 | 397280 | 47425 | 46241213 |
Cardiac failure | 111.86 | 9.91 | 330 | 397094 | 79618 | 46209020 |
Injection site erythema | 109.70 | 9.91 | 1041 | 396383 | 73386 | 46215252 |
Device expulsion | 108.79 | 9.91 | 49 | 397375 | 27493 | 46261145 |
Knee arthroplasty | 107.62 | 9.91 | 443 | 396981 | 23222 | 46265416 |
Musculoskeletal stiffness | 105.94 | 9.91 | 1288 | 396136 | 96705 | 46191933 |
Injection site pain | 105.88 | 9.91 | 1385 | 396039 | 105767 | 46182871 |
Bradycardia | 102.21 | 9.91 | 261 | 397163 | 66037 | 46222601 |
Rhabdomyolysis | 100.73 | 9.91 | 125 | 397299 | 41784 | 46246854 |
Product use issue | 98.86 | 9.91 | 1236 | 396188 | 93408 | 46195230 |
Intentional self-injury | 98.62 | 9.91 | 41 | 397383 | 24125 | 46264513 |
Sickle cell anaemia with crisis | 96.49 | 9.91 | 143 | 397281 | 3849 | 46284789 |
Red blood cell sedimentation rate abnormal | 96.10 | 9.91 | 295 | 397129 | 13354 | 46275284 |
Blood pressure fluctuation | 95.14 | 9.91 | 511 | 396913 | 29937 | 46258701 |
Sopor | 94.18 | 9.91 | 26 | 397398 | 19802 | 46268836 |
Contraindicated product administered | 91.77 | 9.91 | 1063 | 396361 | 78884 | 46209754 |
Discomfort | 87.75 | 9.91 | 689 | 396735 | 45981 | 46242657 |
Neutropenia | 87.46 | 9.91 | 788 | 396636 | 142416 | 46146222 |
Hypotension | 87.32 | 9.91 | 1423 | 396001 | 231166 | 46057472 |
Arthritis | 85.63 | 9.91 | 1021 | 396403 | 76295 | 46212343 |
C-reactive protein abnormal | 82.82 | 9.91 | 380 | 397044 | 20890 | 46267748 |
Sinusitis | 81.28 | 9.91 | 1554 | 395870 | 128214 | 46160424 |
Psoriatic arthropathy | 79.14 | 9.91 | 556 | 396868 | 35823 | 46252815 |
Agitation | 78.77 | 9.91 | 227 | 397197 | 55188 | 46233450 |
Injection site reaction | 78.49 | 9.91 | 685 | 396739 | 47164 | 46241474 |
Renal failure | 78.44 | 9.91 | 605 | 396819 | 112989 | 46175649 |
Cholestasis | 78.42 | 9.91 | 68 | 397356 | 26825 | 46261813 |
Injection site pruritus | 78.20 | 9.91 | 593 | 396831 | 39150 | 46249488 |
Tachycardia | 77.33 | 9.91 | 513 | 396911 | 99109 | 46189529 |
Injection site swelling | 74.51 | 9.91 | 593 | 396831 | 39734 | 46248904 |
Pregnancy | 73.92 | 9.91 | 439 | 396985 | 26698 | 46261940 |
Serotonin syndrome | 73.38 | 9.91 | 59 | 397365 | 24161 | 46264477 |
Hepatic failure | 72.88 | 9.91 | 107 | 397317 | 33309 | 46255329 |
Coma | 70.44 | 9.91 | 257 | 397167 | 58092 | 46230546 |
Hepatocellular injury | 68.93 | 9.91 | 90 | 397334 | 29432 | 46259206 |
Metabolic acidosis | 67.53 | 9.91 | 143 | 397281 | 38637 | 46250001 |
Hepatic function abnormal | 66.82 | 9.91 | 119 | 397305 | 34302 | 46254336 |
Osteoarthritis | 66.02 | 9.91 | 813 | 396611 | 61212 | 46227426 |
Disease progression | 66.00 | 9.91 | 480 | 396944 | 90820 | 46197818 |
Peripheral swelling | 65.81 | 9.91 | 1787 | 395637 | 156284 | 46132354 |
Poisoning | 65.26 | 9.91 | 19 | 397405 | 13975 | 46274663 |
Multiple organ dysfunction syndrome | 64.92 | 9.91 | 224 | 397200 | 51486 | 46237152 |
Respiratory failure | 64.51 | 9.91 | 507 | 396917 | 94309 | 46194329 |
Basal cell carcinoma | 64.11 | 9.91 | 344 | 397080 | 20143 | 46268495 |
Oropharyngeal pain | 60.12 | 9.91 | 926 | 396498 | 73242 | 46215396 |
Product quality issue | 58.34 | 9.91 | 136 | 397288 | 35512 | 46253126 |
Injection site bruising | 56.80 | 9.91 | 507 | 396917 | 35129 | 46253509 |
Cytomegalovirus infection | 56.49 | 9.91 | 43 | 397381 | 18101 | 46270537 |
Dyspnoea | 54.65 | 9.91 | 3718 | 393706 | 511830 | 45776808 |
Pain in extremity | 54.03 | 9.91 | 2706 | 394718 | 255974 | 46032664 |
Shock | 53.71 | 9.91 | 64 | 397360 | 21781 | 46266857 |
Vomiting | 53.71 | 9.91 | 3232 | 394192 | 449562 | 45839076 |
Encephalopathy | 53.49 | 9.91 | 130 | 397294 | 33459 | 46255179 |
Delirium | 53.26 | 9.91 | 152 | 397272 | 37076 | 46251562 |
Anaphylactic reaction | 52.87 | 9.91 | 252 | 397172 | 52860 | 46235778 |
Carotid artery thrombosis | 52.30 | 9.91 | 46 | 397378 | 684 | 46287954 |
Psoriasis | 51.84 | 9.91 | 949 | 396475 | 77655 | 46210983 |
Pulmonary arterial hypertension | 51.82 | 9.91 | 88 | 397336 | 25840 | 46262798 |
Drug resistance | 51.76 | 9.91 | 43 | 397381 | 17325 | 46271313 |
Hypoglycaemia | 51.72 | 9.91 | 262 | 397162 | 54087 | 46234551 |
Disability assessment scale score increased | 51.16 | 9.91 | 78 | 397346 | 2154 | 46286484 |
Drug withdrawal syndrome | 51.09 | 9.91 | 97 | 397327 | 27287 | 46261351 |
Product use in unapproved indication | 50.70 | 9.91 | 507 | 396917 | 89766 | 46198872 |
Thrombocytopenia | 50.61 | 9.91 | 765 | 396659 | 125816 | 46162822 |
Drug dependence | 50.34 | 9.91 | 57 | 397367 | 19844 | 46268794 |
Hyperkalaemia | 50.25 | 9.91 | 241 | 397183 | 50468 | 46238170 |
Blood creatine phosphokinase increased | 50.16 | 9.91 | 100 | 397324 | 27624 | 46261014 |
General physical health deterioration | 50.01 | 9.91 | 689 | 396735 | 115080 | 46173558 |
Abortion spontaneous | 49.91 | 9.91 | 580 | 396844 | 43066 | 46245572 |
Influenza | 49.85 | 9.91 | 1051 | 396373 | 88219 | 46200419 |
Infective pulmonary exacerbation of cystic fibrosis | 49.80 | 9.91 | 15 | 397409 | 10792 | 46277846 |
Helicobacter infection | 49.70 | 9.91 | 215 | 397209 | 11521 | 46277117 |
Confusional state | 49.63 | 9.91 | 1011 | 396413 | 158881 | 46129757 |
Sedation | 49.33 | 9.91 | 74 | 397350 | 22836 | 46265802 |
Neurologic neglect syndrome | 48.69 | 9.91 | 43 | 397381 | 643 | 46287995 |
Joint effusion | 47.96 | 9.91 | 216 | 397208 | 11779 | 46276859 |
Duodenal ulcer perforation | 47.56 | 9.91 | 170 | 397254 | 8332 | 46280306 |
Hyperglycaemia | 46.72 | 9.91 | 148 | 397276 | 34923 | 46253715 |
Weight increased | 46.41 | 9.91 | 1775 | 395649 | 162698 | 46125940 |
Seizure | 46.38 | 9.91 | 752 | 396672 | 122302 | 46166336 |
Mydriasis | 46.24 | 9.91 | 16 | 397408 | 10537 | 46278101 |
Osteonecrosis of jaw | 44.56 | 9.91 | 147 | 397277 | 34255 | 46254383 |
Angioedema | 43.80 | 9.91 | 179 | 397245 | 39163 | 46249475 |
Osteoporosis | 43.52 | 9.91 | 533 | 396891 | 40075 | 46248563 |
Ejection fraction decreased | 42.58 | 9.91 | 54 | 397370 | 17883 | 46270755 |
Joint laxity | 42.17 | 9.91 | 69 | 397355 | 2027 | 46286611 |
Caesarean section | 41.68 | 9.91 | 263 | 397161 | 16340 | 46272298 |
Contusion | 41.63 | 9.91 | 1007 | 396417 | 86480 | 46202158 |
Skin cancer | 41.56 | 9.91 | 167 | 397257 | 8656 | 46279982 |
Therapeutic product effect decreased | 41.52 | 9.91 | 958 | 396466 | 81643 | 46206995 |
Localised infection | 41.27 | 9.91 | 345 | 397079 | 23456 | 46265182 |
Renal impairment | 41.21 | 9.91 | 419 | 397005 | 73953 | 46214685 |
Heart rate decreased | 41.05 | 9.91 | 432 | 396992 | 31291 | 46257347 |
Respiratory depression | 40.81 | 9.91 | 24 | 397400 | 11576 | 46277062 |
Full blood count decreased | 40.69 | 9.91 | 326 | 397098 | 21885 | 46266753 |
Palmar-plantar erythrodysaesthesia syndrome | 40.33 | 9.91 | 70 | 397354 | 20381 | 46268257 |
Torsade de pointes | 40.20 | 9.91 | 27 | 397397 | 12127 | 46276511 |
Cardiac failure congestive | 40.00 | 9.91 | 545 | 396879 | 91205 | 46197433 |
Posterior reversible encephalopathy syndrome | 39.81 | 9.91 | 42 | 397382 | 15099 | 46273539 |
Myocardial infarction | 39.11 | 9.91 | 589 | 396835 | 96939 | 46191699 |
Hypothermia | 39.05 | 9.91 | 28 | 397396 | 12155 | 46276483 |
Impaired healing | 38.82 | 9.91 | 481 | 396943 | 36262 | 46252376 |
Acute hepatic failure | 38.52 | 9.91 | 41 | 397383 | 14680 | 46273958 |
Somnolence | 38.41 | 9.91 | 1026 | 396398 | 155495 | 46133143 |
Accidental overdose | 38.38 | 9.91 | 70 | 397354 | 19996 | 46268642 |
Ventricular tachycardia | 38.31 | 9.91 | 53 | 397371 | 16914 | 46271724 |
Altered state of consciousness | 38.26 | 9.91 | 89 | 397335 | 23259 | 46265379 |
Adjustment disorder | 38.04 | 9.91 | 53 | 397371 | 1346 | 46287292 |
Neuroleptic malignant syndrome | 37.75 | 9.91 | 24 | 397400 | 11098 | 46277540 |
Agranulocytosis | 37.63 | 9.91 | 83 | 397341 | 22102 | 46266536 |
Injection site rash | 37.56 | 9.91 | 247 | 397177 | 15566 | 46273072 |
Jaundice | 37.54 | 9.91 | 123 | 397301 | 28722 | 46259916 |
Herpes zoster | 37.53 | 9.91 | 798 | 396626 | 67074 | 46221564 |
Weight decreased | 37.47 | 9.91 | 2173 | 395251 | 208676 | 46079962 |
Neck deformity | 37.26 | 9.91 | 61 | 397363 | 1793 | 46286845 |
Hypokalaemia | 37.25 | 9.91 | 526 | 396898 | 87498 | 46201140 |
Acute generalised exanthematous pustulosis | 36.72 | 9.91 | 17 | 397407 | 9388 | 46279250 |
Transplant rejection | 36.47 | 9.91 | 18 | 397406 | 9578 | 46279060 |
Leukopenia | 36.25 | 9.91 | 389 | 397035 | 67954 | 46220684 |
Emotional distress | 35.91 | 9.91 | 137 | 397287 | 30570 | 46258068 |
No adverse event | 35.50 | 9.91 | 160 | 397264 | 34071 | 46254567 |
Blood pressure diastolic abnormal | 35.33 | 9.91 | 126 | 397298 | 6168 | 46282470 |
Aspartate aminotransferase increased | 34.84 | 9.91 | 466 | 396958 | 78234 | 46210404 |
International normalised ratio increased | 34.58 | 9.91 | 245 | 397179 | 46638 | 46242000 |
Intentional product misuse | 34.41 | 9.91 | 247 | 397177 | 46881 | 46241757 |
Femur fracture | 34.35 | 9.91 | 473 | 396951 | 36524 | 46252114 |
Intestinal stenosis | 34.22 | 9.91 | 70 | 397354 | 2451 | 46286187 |
Off label use | 34.12 | 9.91 | 2777 | 394647 | 377064 | 45911574 |
Hypoxia | 33.94 | 9.91 | 280 | 397144 | 51558 | 46237080 |
Alanine aminotransferase increased | 33.83 | 9.91 | 539 | 396885 | 87912 | 46200726 |
Asthma | 33.31 | 9.91 | 563 | 396861 | 90979 | 46197659 |
Disseminated intravascular coagulation | 33.15 | 9.91 | 70 | 397354 | 18935 | 46269703 |
Gamma-glutamyltransferase increased | 33.13 | 9.91 | 148 | 397276 | 31592 | 46257046 |
Drug level increased | 32.95 | 9.91 | 67 | 397357 | 18374 | 46270264 |
Gastroenteritis viral | 32.68 | 9.91 | 265 | 397159 | 17854 | 46270784 |
Respiratory distress | 32.61 | 9.91 | 150 | 397274 | 31766 | 46256872 |
Pyrexia | 32.56 | 9.91 | 2542 | 394882 | 346260 | 45942378 |
Loss of personal independence in daily activities | 32.48 | 9.91 | 675 | 396749 | 56508 | 46232130 |
Blood pressure increased | 32.22 | 9.91 | 1352 | 396072 | 125314 | 46163324 |
Lower respiratory tract infection | 32.19 | 9.91 | 653 | 396771 | 54436 | 46234202 |
Live birth | 32.01 | 9.91 | 173 | 397251 | 10157 | 46278481 |
Pre-eclampsia | 32.00 | 9.91 | 144 | 397280 | 7850 | 46280788 |
Pulmonary embolism | 31.79 | 9.91 | 693 | 396731 | 107892 | 46180746 |
Maternal drugs affecting foetus | 31.43 | 9.91 | 111 | 397313 | 5407 | 46283231 |
Disorientation | 31.26 | 9.91 | 185 | 397239 | 36733 | 46251905 |
Unresponsive to stimuli | 31.24 | 9.91 | 154 | 397270 | 32020 | 46256618 |
Gestational diabetes | 31.15 | 9.91 | 133 | 397291 | 7086 | 46281552 |
Surgery | 30.92 | 9.91 | 378 | 397046 | 28407 | 46260231 |
Neck mass | 30.89 | 9.91 | 79 | 397345 | 3214 | 46285424 |
Bronchitis | 30.89 | 9.91 | 1148 | 396276 | 104831 | 46183807 |
Carpal tunnel syndrome | 30.83 | 9.91 | 236 | 397188 | 15623 | 46273015 |
Ascites | 30.62 | 9.91 | 184 | 397240 | 36400 | 46252238 |
Anxiety | 30.38 | 9.91 | 1253 | 396171 | 180704 | 46107934 |
Anaphylactic shock | 30.33 | 9.91 | 81 | 397343 | 20193 | 46268445 |
Premature labour | 30.26 | 9.91 | 182 | 397242 | 11117 | 46277521 |
Blood bilirubin increased | 30.18 | 9.91 | 169 | 397255 | 34015 | 46254623 |
Malignant melanoma | 30.11 | 9.91 | 169 | 397255 | 10065 | 46278573 |
Ventricular septal defect | 30.10 | 9.91 | 89 | 397335 | 3945 | 46284693 |
Cerebral haemorrhage | 29.78 | 9.91 | 132 | 397292 | 28239 | 46260399 |
Psychotic disorder | 29.75 | 9.91 | 96 | 397328 | 22525 | 46266113 |
Metastases to liver | 29.48 | 9.91 | 78 | 397346 | 19507 | 46269131 |
Urticaria | 29.38 | 9.91 | 771 | 396653 | 117121 | 46171517 |
Syncope | 29.22 | 9.91 | 674 | 396750 | 104129 | 46184509 |
Blood alkaline phosphatase increased | 29.21 | 9.91 | 207 | 397217 | 39402 | 46249236 |
Coagulopathy | 29.14 | 9.91 | 72 | 397352 | 18427 | 46270211 |
Blood pressure systolic abnormal | 28.91 | 9.91 | 108 | 397316 | 5409 | 46283229 |
Neurotoxicity | 28.87 | 9.91 | 45 | 397379 | 13672 | 46274966 |
Graft versus host disease | 28.84 | 9.91 | 10 | 397414 | 6578 | 46282060 |
Juvenile idiopathic arthritis | 28.80 | 9.91 | 89 | 397335 | 4043 | 46284595 |
Fall | 28.78 | 9.91 | 3211 | 394213 | 325886 | 45962752 |
Haemoglobin decreased | 28.76 | 9.91 | 1358 | 396066 | 127591 | 46161047 |
Akathisia | 28.52 | 9.91 | 15 | 397409 | 7699 | 46280939 |
Myalgia | 28.35 | 9.91 | 814 | 396610 | 122274 | 46166364 |
Arrhythmia | 28.24 | 9.91 | 177 | 397247 | 34664 | 46253974 |
Brain oedema | 28.15 | 9.91 | 39 | 397385 | 12439 | 46276199 |
Ventricular fibrillation | 27.92 | 9.91 | 34 | 397390 | 11462 | 46277176 |
Rheumatoid nodule | 27.91 | 9.91 | 151 | 397273 | 8869 | 46279769 |
Diabetic ketoacidosis | 27.81 | 9.91 | 72 | 397352 | 18138 | 46270500 |
Toxic skin eruption | 27.66 | 9.91 | 39 | 397385 | 12348 | 46276290 |
Forced expiratory volume decreased | 27.64 | 9.91 | 5 | 397419 | 5099 | 46283539 |
Metastases to bone | 27.54 | 9.91 | 68 | 397356 | 17408 | 46271230 |
Status epilepticus | 27.43 | 9.91 | 48 | 397376 | 13931 | 46274707 |
Bone marrow failure | 27.11 | 9.91 | 145 | 397279 | 29524 | 46259114 |
Blood pressure systolic increased | 27.11 | 9.91 | 369 | 397055 | 28418 | 46260220 |
Red blood cell sedimentation rate increased | 26.98 | 9.91 | 306 | 397118 | 22583 | 46266055 |
Blood pressure diastolic decreased | 26.81 | 9.91 | 210 | 397214 | 14001 | 46274637 |
Musculoskeletal pain | 26.69 | 9.91 | 784 | 396640 | 69344 | 46219294 |
Grip strength decreased | 26.58 | 9.91 | 144 | 397280 | 8462 | 46280176 |
Fibromyalgia | 26.44 | 9.91 | 447 | 396977 | 36016 | 46252622 |
Cardiogenic shock | 26.41 | 9.91 | 63 | 397361 | 16321 | 46272317 |
Rash maculo-papular | 26.16 | 9.91 | 135 | 397289 | 27739 | 46260899 |
Small for dates baby | 25.97 | 9.91 | 79 | 397345 | 3558 | 46285080 |
Nodule | 25.89 | 9.91 | 224 | 397200 | 15381 | 46273257 |
Mental status changes | 25.73 | 9.91 | 204 | 397220 | 37884 | 46250754 |
Frequent bowel movements | 25.70 | 9.91 | 190 | 397234 | 12442 | 46276196 |
Urinary tract infection | 25.52 | 9.91 | 2192 | 395232 | 218074 | 46070564 |
Developmental hip dysplasia | 25.49 | 9.91 | 42 | 397382 | 1241 | 46287397 |
Tumour lysis syndrome | 25.41 | 9.91 | 15 | 397409 | 7221 | 46281417 |
Foot deformity | 25.37 | 9.91 | 221 | 397203 | 15204 | 46273434 |
Suicidal ideation | 25.26 | 9.91 | 333 | 397091 | 56049 | 46232589 |
Cystitis | 25.10 | 9.91 | 502 | 396922 | 41739 | 46246899 |
Blood glucose increased | 24.88 | 9.91 | 447 | 396977 | 71566 | 46217072 |
Red blood cell count decreased | 24.79 | 9.91 | 403 | 397021 | 32220 | 46256418 |
Extrapyramidal disorder | 24.65 | 9.91 | 36 | 397388 | 11232 | 46277406 |
Inappropriate antidiuretic hormone secretion | 24.55 | 9.91 | 52 | 397372 | 14050 | 46274588 |
Miosis | 24.53 | 9.91 | 13 | 397411 | 6644 | 46281994 |
Cholecystitis chronic | 24.51 | 9.91 | 32 | 397392 | 10467 | 46278171 |
Acute myeloid leukaemia | 24.39 | 9.91 | 62 | 397362 | 15716 | 46272922 |
Arthritis infective | 24.26 | 9.91 | 97 | 397327 | 5016 | 46283622 |
Thrombotic microangiopathy | 24.22 | 9.91 | 21 | 397403 | 8285 | 46280353 |
Pancreatitis acute | 24.17 | 9.91 | 119 | 397305 | 24753 | 46263885 |
Pleural effusion | 24.10 | 9.91 | 530 | 396894 | 82422 | 46206216 |
Foot fracture | 24.09 | 9.91 | 264 | 397160 | 19318 | 46269320 |
Tachypnoea | 24.09 | 9.91 | 54 | 397370 | 14297 | 46274341 |
Cyst | 24.05 | 9.91 | 181 | 397243 | 11919 | 46276719 |
Face oedema | 24.01 | 9.91 | 83 | 397341 | 19070 | 46269568 |
Abnormal behaviour | 23.95 | 9.91 | 95 | 397329 | 20963 | 46267675 |
Drug-induced liver injury | 23.73 | 9.91 | 123 | 397301 | 25245 | 46263393 |
Injury | 23.58 | 9.91 | 250 | 397174 | 43777 | 46244861 |
Vitamin B12 deficiency | 23.50 | 9.91 | 81 | 397343 | 3898 | 46284740 |
Asphyxia | 23.46 | 9.91 | 8 | 397416 | 5318 | 46283320 |
Schizophrenia | 23.40 | 9.91 | 23 | 397401 | 8545 | 46280093 |
Smear cervix abnormal | 23.23 | 9.91 | 60 | 397364 | 2456 | 46286182 |
Upper respiratory tract infection | 23.23 | 9.91 | 707 | 396717 | 62849 | 46225789 |
Sinus tachycardia | 23.17 | 9.91 | 100 | 397324 | 21549 | 46267089 |
Cellulitis | 23.10 | 9.91 | 772 | 396652 | 69516 | 46219122 |
Product dose omission issue | 23.09 | 9.91 | 1699 | 395725 | 166821 | 46121817 |
Limb deformity | 23.07 | 9.91 | 75 | 397349 | 3501 | 46285137 |
Skin papilloma | 22.93 | 9.91 | 83 | 397341 | 4093 | 46284545 |
Squamous cell carcinoma | 22.79 | 9.91 | 129 | 397295 | 7707 | 46280931 |
Disturbance in attention | 22.75 | 9.91 | 166 | 397258 | 31394 | 46257244 |
Ischaemic stroke | 22.67 | 9.91 | 70 | 397354 | 16652 | 46271986 |
Eye infection | 22.58 | 9.91 | 144 | 397280 | 8979 | 46279659 |
Loss of consciousness | 22.41 | 9.91 | 726 | 396698 | 107512 | 46181126 |
Product administration error | 22.25 | 9.91 | 89 | 397335 | 19592 | 46269046 |
Postoperative wound infection | 22.19 | 9.91 | 139 | 397285 | 8614 | 46280024 |
Therapeutic response decreased | 22.17 | 9.91 | 502 | 396922 | 42643 | 46245995 |
Haemophagocytic lymphohistiocytosis | 22.09 | 9.91 | 23 | 397401 | 8319 | 46280319 |
Synovial cyst | 22.07 | 9.91 | 122 | 397302 | 7224 | 46281414 |
Pancreatitis | 22.06 | 9.91 | 251 | 397173 | 43376 | 46245262 |
Injection site warmth | 21.97 | 9.91 | 196 | 397228 | 13576 | 46275062 |
Fear | 21.71 | 9.91 | 68 | 397356 | 16104 | 46272534 |
Anaemia | 21.71 | 9.91 | 1878 | 395546 | 253901 | 46034737 |
Hepatic enzyme increased | 21.71 | 9.91 | 877 | 396547 | 80910 | 46207728 |
Nausea | 21.69 | 9.91 | 5359 | 392065 | 682095 | 45606543 |
Tooth disorder | 21.66 | 9.91 | 298 | 397126 | 23005 | 46265633 |
Unintentional medical device removal | 21.57 | 9.91 | 6 | 397418 | 4547 | 46284091 |
Aggression | 21.43 | 9.91 | 110 | 397314 | 22634 | 46266004 |
Tuberculosis | 21.22 | 9.91 | 155 | 397269 | 10110 | 46278528 |
Stevens-Johnson syndrome | 21.21 | 9.91 | 114 | 397310 | 23183 | 46265455 |
Pharyngitis streptococcal | 21.17 | 9.91 | 134 | 397290 | 8334 | 46280304 |
Stress cardiomyopathy | 21.13 | 9.91 | 21 | 397403 | 7763 | 46280875 |
Restlessness | 21.03 | 9.91 | 129 | 397295 | 25395 | 46263243 |
Sepsis | 20.94 | 9.91 | 945 | 396479 | 135069 | 46153569 |
Toxic epidermal necrolysis | 20.85 | 9.91 | 108 | 397316 | 22170 | 46266468 |
Hyperhidrosis | 20.71 | 9.91 | 590 | 396834 | 88718 | 46199920 |
Transplant dysfunction | 20.68 | 9.91 | 7 | 397417 | 4675 | 46283963 |
Substance abuse | 20.68 | 9.91 | 5 | 397419 | 4162 | 46284476 |
Pathogen resistance | 20.67 | 9.91 | 13 | 397411 | 6047 | 46282591 |
Tenosynovitis stenosans | 20.66 | 9.91 | 49 | 397375 | 1900 | 46286738 |
Mania | 20.60 | 9.91 | 38 | 397386 | 10808 | 46277830 |
Multiple fractures | 20.60 | 9.91 | 98 | 397326 | 5469 | 46283169 |
Hallucination | 20.59 | 9.91 | 300 | 397124 | 49651 | 46238987 |
Hepatotoxicity | 20.29 | 9.91 | 127 | 397297 | 24882 | 46263756 |
Myoclonus | 20.23 | 9.91 | 59 | 397365 | 14293 | 46274345 |
Circulatory collapse | 20.14 | 9.91 | 105 | 397319 | 21519 | 46267119 |
Inflammation | 20.12 | 9.91 | 551 | 396873 | 48230 | 46240408 |
Oral herpes | 20.12 | 9.91 | 253 | 397171 | 19137 | 46269501 |
Post procedural infection | 20.11 | 9.91 | 121 | 397303 | 7392 | 46281246 |
Skin ulcer | 20.05 | 9.91 | 388 | 397036 | 32070 | 46256568 |
Poor venous access | 19.87 | 9.91 | 130 | 397294 | 8178 | 46280460 |
Anhedonia | 19.81 | 9.91 | 36 | 397388 | 10299 | 46278339 |
Myopathy | 19.79 | 9.91 | 28 | 397396 | 8853 | 46279785 |
Rash | 19.73 | 9.91 | 3386 | 394038 | 353126 | 45935512 |
Acute graft versus host disease | 19.68 | 9.91 | 5 | 397419 | 4025 | 46284613 |
Immunodeficiency | 19.63 | 9.91 | 184 | 397240 | 12922 | 46275716 |
Melaena | 19.58 | 9.91 | 147 | 397277 | 27625 | 46261013 |
Joint destruction | 19.53 | 9.91 | 64 | 397360 | 3000 | 46285638 |
Speech disorder | 19.52 | 9.91 | 205 | 397219 | 35962 | 46252676 |
Respiratory disorder | 19.48 | 9.91 | 144 | 397280 | 27156 | 46261482 |
Aspergillus infection | 19.39 | 9.91 | 18 | 397406 | 6872 | 46281766 |
Benign neoplasm of adrenal gland | 19.31 | 9.91 | 8 | 397416 | 24 | 46288614 |
Febrile bone marrow aplasia | 19.23 | 9.91 | 18 | 397406 | 6844 | 46281794 |
Product complaint | 19.14 | 9.91 | 47 | 397377 | 12054 | 46276584 |
Atrioventricular block complete | 19.12 | 9.91 | 22 | 397402 | 7605 | 46281033 |
Device difficult to use | 19.10 | 9.91 | 24 | 397400 | 7980 | 46280658 |
Bronchospasm | 19.07 | 9.91 | 69 | 397355 | 15638 | 46273000 |
Stress | 18.98 | 9.91 | 574 | 396850 | 50977 | 46237661 |
Joint injury | 18.82 | 9.91 | 248 | 397176 | 18961 | 46269677 |
Right aortic arch | 18.78 | 9.91 | 17 | 397407 | 263 | 46288375 |
Injection site haematoma | 18.70 | 9.91 | 102 | 397322 | 6010 | 46282628 |
Eosinophilia | 18.64 | 9.91 | 92 | 397332 | 19125 | 46269513 |
Bone erosion | 18.62 | 9.91 | 141 | 397283 | 9302 | 46279336 |
Orthostatic hypotension | 18.60 | 9.91 | 128 | 397296 | 24530 | 46264108 |
Polyneuropathy | 18.59 | 9.91 | 45 | 397379 | 11599 | 46277039 |
Oedema | 18.50 | 9.91 | 432 | 396992 | 66639 | 46221999 |
Haematotoxicity | 18.49 | 9.91 | 19 | 397405 | 6914 | 46281724 |
Blood pressure diastolic increased | 18.48 | 9.91 | 100 | 397324 | 5874 | 46282764 |
Foetal exposure during pregnancy | 18.47 | 9.91 | 366 | 397058 | 30381 | 46258257 |
Hypomagnesaemia | 18.43 | 9.91 | 112 | 397312 | 22098 | 46266540 |
Erythema multiforme | 18.43 | 9.91 | 34 | 397390 | 9670 | 46278968 |
Bronchopulmonary aspergillosis | 18.39 | 9.91 | 22 | 397402 | 7474 | 46281164 |
Immunosuppression | 18.33 | 9.91 | 118 | 397306 | 7382 | 46281256 |
Obstructive airways disorder | 18.29 | 9.91 | 56 | 397368 | 13356 | 46275282 |
Blood iron decreased | 18.26 | 9.91 | 159 | 397265 | 10938 | 46277700 |
Diverticulitis | 18.11 | 9.91 | 388 | 397036 | 32651 | 46255987 |
Dyspnoea exertional | 18.05 | 9.91 | 310 | 397114 | 49979 | 46238659 |
Disability | 17.96 | 9.91 | 148 | 397276 | 10019 | 46278619 |
Swollen joint count increased | 17.96 | 9.91 | 53 | 397371 | 2347 | 46286291 |
Premature rupture of membranes | 17.95 | 9.91 | 80 | 397344 | 4343 | 46284295 |
Tremor | 17.89 | 9.91 | 803 | 396621 | 114836 | 46173802 |
Melanocytic naevus | 17.87 | 9.91 | 73 | 397351 | 3812 | 46284826 |
Bradyphrenia | 17.86 | 9.91 | 16 | 397408 | 6214 | 46282424 |
Hypocalcaemia | 17.84 | 9.91 | 144 | 397280 | 26641 | 46261997 |
Neutrophil count decreased | 17.83 | 9.91 | 261 | 397163 | 43165 | 46245473 |
Rheumatic fever | 17.78 | 9.91 | 59 | 397365 | 2784 | 46285854 |
Sensory loss | 17.74 | 9.91 | 110 | 397314 | 6792 | 46281846 |
Catatonia | 17.74 | 9.91 | 5 | 397419 | 3757 | 46284881 |
Cytomegalovirus viraemia | 17.63 | 9.91 | 8 | 397416 | 4470 | 46284168 |
Anuria | 17.61 | 9.91 | 45 | 397379 | 11386 | 46277252 |
Tardive dyskinesia | 17.60 | 9.91 | 23 | 397401 | 7520 | 46281118 |
Device dislocation | 17.54 | 9.91 | 111 | 397313 | 21691 | 46266947 |
Bone density abnormal | 17.53 | 9.91 | 62 | 397362 | 3022 | 46285616 |
Pulmonary hypertension | 17.46 | 9.91 | 209 | 397215 | 35784 | 46252854 |
Haemoptysis | 17.35 | 9.91 | 141 | 397283 | 26048 | 46262590 |
Wheezing | 17.31 | 9.91 | 335 | 397089 | 53051 | 46235587 |
Device use error | 17.19 | 9.91 | 11 | 397413 | 5070 | 46283568 |
Blood creatinine increased | 17.14 | 9.91 | 507 | 396917 | 75896 | 46212742 |
Hernia | 17.05 | 9.91 | 141 | 397283 | 9554 | 46279084 |
Injection site irritation | 16.99 | 9.91 | 77 | 397347 | 4210 | 46284428 |
Knee operation | 16.98 | 9.91 | 83 | 397341 | 4683 | 46283955 |
Enthesopathy | 16.94 | 9.91 | 82 | 397342 | 4608 | 46284030 |
Sedation complication | 16.90 | 9.91 | 5 | 397419 | 3640 | 46284998 |
Nephrolithiasis | 16.80 | 9.91 | 384 | 397040 | 32667 | 46255971 |
Parkinsonism | 16.80 | 9.91 | 26 | 397398 | 7922 | 46280716 |
Proteinuria | 16.79 | 9.91 | 78 | 397346 | 16475 | 46272163 |
Polyhydramnios | 16.76 | 9.91 | 46 | 397378 | 1953 | 46286685 |
Renal injury | 16.76 | 9.91 | 35 | 397389 | 9506 | 46279132 |
Joint stiffness | 16.72 | 9.91 | 324 | 397100 | 26784 | 46261854 |
Complication associated with device | 16.72 | 9.91 | 71 | 397353 | 15370 | 46273268 |
Tooth infection | 16.69 | 9.91 | 169 | 397255 | 12117 | 46276521 |
Metastases to central nervous system | 16.65 | 9.91 | 45 | 397379 | 11176 | 46277462 |
Ear infection | 16.64 | 9.91 | 282 | 397142 | 22731 | 46265907 |
Neoplasm progression | 16.62 | 9.91 | 146 | 397278 | 26537 | 46262101 |
Faecal calprotectin increased | 16.60 | 9.91 | 43 | 397381 | 1763 | 46286875 |
Pulseless electrical activity | 16.57 | 9.91 | 22 | 397402 | 7145 | 46281493 |
Latent tuberculosis | 16.33 | 9.91 | 45 | 397379 | 1915 | 46286723 |
Atrial septal defect | 16.33 | 9.91 | 101 | 397323 | 6231 | 46282407 |
Spinal stenosis | 16.31 | 9.91 | 171 | 397253 | 12372 | 46276266 |
Pregnancy with contraceptive device | 16.29 | 9.91 | 9 | 397415 | 4494 | 46284144 |
Catheter site pain | 16.28 | 9.91 | 6 | 397418 | 3800 | 46284838 |
Hyperthermia | 16.20 | 9.91 | 27 | 397397 | 7987 | 46280651 |
Hiatus hernia | 16.18 | 9.91 | 232 | 397192 | 18070 | 46270568 |
Injection site haemorrhage | 16.17 | 9.91 | 257 | 397167 | 20452 | 46268186 |
Breast feeding | 16.11 | 9.91 | 28 | 397396 | 865 | 46287773 |
Acute chest syndrome | 16.11 | 9.91 | 22 | 397402 | 548 | 46288090 |
Hallucination, auditory | 16.07 | 9.91 | 43 | 397381 | 10713 | 46277925 |
Chest discomfort | 16.04 | 9.91 | 617 | 396807 | 89652 | 46198986 |
Rhinorrhoea | 16.04 | 9.91 | 525 | 396899 | 47140 | 46241498 |
Coronary artery disease | 15.98 | 9.91 | 197 | 397227 | 33555 | 46255083 |
Viral infection | 15.91 | 9.91 | 353 | 397071 | 29882 | 46258756 |
Clear cell renal cell carcinoma | 15.90 | 9.91 | 30 | 397394 | 989 | 46287649 |
Drug abuser | 15.81 | 9.91 | 4 | 397420 | 3229 | 46285409 |
Limb injury | 15.76 | 9.91 | 240 | 397184 | 18934 | 46269704 |
Metabolic surgery | 15.69 | 9.91 | 29 | 397395 | 941 | 46287697 |
Ketoacidosis | 15.67 | 9.91 | 7 | 397417 | 3948 | 46284690 |
Placental disorder | 15.56 | 9.91 | 36 | 397388 | 1373 | 46287265 |
Hypomania | 15.55 | 9.91 | 9 | 397415 | 4379 | 46284259 |
Intervertebral disc degeneration | 15.54 | 9.91 | 177 | 397247 | 13075 | 46275563 |
Foreign body in reproductive tract | 15.44 | 9.91 | 15 | 397409 | 255 | 46288383 |
Genital haemorrhage | 15.34 | 9.91 | 20 | 397404 | 6546 | 46282092 |
Dry eye | 15.32 | 9.91 | 352 | 397072 | 29970 | 46258668 |
Haemorrhage | 15.25 | 9.91 | 353 | 397071 | 54516 | 46234122 |
Epilepsy | 15.18 | 9.91 | 129 | 397295 | 23609 | 46265029 |
Condition aggravated | 15.18 | 9.91 | 2342 | 395082 | 242710 | 46045928 |
Uterine perforation | 15.14 | 9.91 | 24 | 397400 | 7243 | 46281395 |
Premature delivery | 15.08 | 9.91 | 268 | 397156 | 21801 | 46266837 |
Laryngitis | 15.08 | 9.91 | 133 | 397291 | 9183 | 46279455 |
Injection site urticaria | 15.03 | 9.91 | 162 | 397262 | 11805 | 46276833 |
Injection site induration | 15.03 | 9.91 | 119 | 397305 | 7960 | 46280678 |
Mouth ulceration | 14.99 | 9.91 | 316 | 397108 | 26516 | 46262122 |
Skin laceration | 14.98 | 9.91 | 231 | 397193 | 18271 | 46270367 |
Synovial fluid analysis | 14.98 | 9.91 | 35 | 397389 | 1344 | 46287294 |
Tenderness | 14.93 | 9.91 | 214 | 397210 | 16667 | 46271971 |
Congenital arterial malformation | 14.92 | 9.91 | 17 | 397407 | 350 | 46288288 |
Therapeutic reaction time decreased | 14.91 | 9.91 | 30 | 397394 | 1038 | 46287600 |
Serum ferritin increased | 14.73 | 9.91 | 86 | 397338 | 5197 | 46283441 |
Pemphigoid | 14.72 | 9.91 | 16 | 397408 | 5675 | 46282963 |
Soft tissue mass | 14.71 | 9.91 | 15 | 397409 | 271 | 46288367 |
Blood iron increased | 14.69 | 9.91 | 34 | 397390 | 1297 | 46287341 |
Increased tendency to bruise | 14.69 | 9.91 | 134 | 397290 | 9340 | 46279298 |
Ingrown hair | 14.67 | 9.91 | 19 | 397405 | 449 | 46288189 |
Dystonia | 14.65 | 9.91 | 48 | 397376 | 11209 | 46277429 |
Intestinal resection | 14.59 | 9.91 | 47 | 397377 | 2183 | 46286455 |
Septic shock | 14.57 | 9.91 | 378 | 397046 | 57515 | 46231123 |
Cytokine release syndrome | 14.49 | 9.91 | 19 | 397405 | 6204 | 46282434 |
Incorrect route of product administration | 14.46 | 9.91 | 81 | 397343 | 16302 | 46272336 |
Wheelchair user | 14.43 | 9.91 | 70 | 397354 | 3938 | 46284700 |
Burning sensation | 14.39 | 9.91 | 487 | 396937 | 43924 | 46244714 |
Metastases to lung | 14.34 | 9.91 | 45 | 397379 | 10651 | 46277987 |
Acidosis | 14.29 | 9.91 | 48 | 397376 | 11126 | 46277512 |
Polyarthritis | 14.23 | 9.91 | 100 | 397324 | 6442 | 46282196 |
Abortion incomplete | 14.21 | 9.91 | 5 | 397419 | 3259 | 46285379 |
Cardiotoxicity | 14.19 | 9.91 | 22 | 397402 | 6700 | 46281938 |
Accidental exposure to product | 14.19 | 9.91 | 113 | 397311 | 20968 | 46267670 |
Breast cancer metastatic | 14.14 | 9.91 | 64 | 397360 | 13614 | 46275024 |
Hypertransaminasaemia | 14.10 | 9.91 | 6 | 397418 | 3482 | 46285156 |
Pulmonary alveolar haemorrhage | 14.10 | 9.91 | 9 | 397415 | 4153 | 46284485 |
Cyanosis | 14.07 | 9.91 | 79 | 397345 | 15892 | 46272746 |
Viral upper respiratory tract infection | 13.96 | 9.91 | 105 | 397319 | 6913 | 46281725 |
Loose body in joint | 13.96 | 9.91 | 29 | 397395 | 1027 | 46287611 |
Interstitial lung disease | 13.91 | 9.91 | 351 | 397073 | 53598 | 46235040 |
Fracture | 13.86 | 9.91 | 207 | 397217 | 16264 | 46272374 |
Rectal abscess | 13.85 | 9.91 | 28 | 397396 | 972 | 46287666 |
Pulmonary tuberculosis | 13.83 | 9.91 | 78 | 397346 | 4653 | 46283985 |
Dermatitis exfoliative | 13.78 | 9.91 | 17 | 397407 | 5699 | 46282939 |
Arthropod bite | 13.73 | 9.91 | 91 | 397333 | 5750 | 46282888 |
Cataract | 13.72 | 9.91 | 494 | 396930 | 44921 | 46243717 |
Hyperprolactinaemia | 13.64 | 9.91 | 4 | 397420 | 2928 | 46285710 |
Cerebral infarction | 13.62 | 9.91 | 130 | 397294 | 23236 | 46265402 |
Scleritis | 13.62 | 9.91 | 55 | 397369 | 2857 | 46285781 |
Antibody test positive | 13.60 | 9.91 | 45 | 397379 | 2120 | 46286518 |
Vitamin B12 decreased | 13.45 | 9.91 | 53 | 397371 | 2722 | 46285916 |
Acute respiratory failure | 13.45 | 9.91 | 171 | 397253 | 28967 | 46259671 |
Synovial disorder | 13.40 | 9.91 | 25 | 397399 | 817 | 46287821 |
Cardiomyopathy | 13.36 | 9.91 | 81 | 397343 | 15992 | 46272646 |
Kidney infection | 13.36 | 9.91 | 209 | 397215 | 16580 | 46272058 |
Wrong product administered | 13.31 | 9.91 | 17 | 397407 | 5613 | 46283025 |
Pain in jaw | 13.30 | 9.91 | 238 | 397186 | 38134 | 46250504 |
Shock haemorrhagic | 13.24 | 9.91 | 34 | 397390 | 8590 | 46280048 |
Cervical incompetence | 13.20 | 9.91 | 21 | 397403 | 602 | 46288036 |
Joint noise | 13.20 | 9.91 | 58 | 397366 | 3129 | 46285509 |
Body height below normal | 13.18 | 9.91 | 40 | 397384 | 1799 | 46286839 |
Liver injury | 13.12 | 9.91 | 81 | 397343 | 15920 | 46272718 |
Oliguria | 13.09 | 9.91 | 35 | 397389 | 8724 | 46279914 |
Hepatitis cholestatic | 13.03 | 9.91 | 23 | 397401 | 6654 | 46281984 |
Morning sickness | 13.02 | 9.91 | 22 | 397402 | 664 | 46287974 |
Hepatocellular carcinoma | 12.97 | 9.91 | 4 | 397420 | 2835 | 46285803 |
Medication error | 12.97 | 9.91 | 185 | 397239 | 30726 | 46257912 |
Hypoglycaemic coma | 12.95 | 9.91 | 3 | 397421 | 2571 | 46286067 |
Deep vein thrombosis | 12.94 | 9.91 | 551 | 396873 | 79222 | 46209416 |
Product substitution issue | 12.89 | 9.91 | 75 | 397349 | 14956 | 46273682 |
Gestational hypertension | 12.84 | 9.91 | 44 | 397380 | 2111 | 46286527 |
Haematocrit decreased | 12.81 | 9.91 | 390 | 397034 | 34667 | 46253971 |
Pulmonary oedema | 12.78 | 9.91 | 334 | 397090 | 50771 | 46237867 |
Foetal distress syndrome | 12.74 | 9.91 | 31 | 397393 | 1222 | 46287416 |
Acute myocardial infarction | 12.72 | 9.91 | 193 | 397231 | 31731 | 46256907 |
Osteonecrosis | 12.67 | 9.91 | 149 | 397275 | 25595 | 46263043 |
Cartilage injury | 12.65 | 9.91 | 36 | 397388 | 1561 | 46287077 |
Intentional product use issue | 12.65 | 9.91 | 560 | 396864 | 52220 | 46236418 |
Purging | 12.64 | 9.91 | 7 | 397417 | 46 | 46288592 |
Exomphalos | 12.59 | 9.91 | 19 | 397405 | 520 | 46288118 |
Hyperuricaemia | 12.49 | 9.91 | 13 | 397411 | 4704 | 46283934 |
Pseudomonas infection | 12.43 | 9.91 | 42 | 397382 | 9716 | 46278922 |
Acute coronary syndrome | 12.27 | 9.91 | 45 | 397379 | 10159 | 46278479 |
Body temperature decreased | 12.27 | 9.91 | 171 | 397253 | 13238 | 46275400 |
Labelled drug-drug interaction medication error | 12.23 | 9.91 | 38 | 397386 | 9023 | 46279615 |
Tonsillar inflammation | 12.23 | 9.91 | 9 | 397415 | 102 | 46288536 |
Trichoglossia | 12.22 | 9.91 | 10 | 397414 | 134 | 46288504 |
Pulmonary haemorrhage | 12.17 | 9.91 | 23 | 397401 | 6482 | 46282156 |
Chronic graft versus host disease | 12.17 | 9.91 | 4 | 397420 | 2721 | 46285917 |
Thyroid function test abnormal | 12.16 | 9.91 | 57 | 397367 | 3161 | 46285477 |
Hepatic necrosis | 12.15 | 9.91 | 18 | 397406 | 5583 | 46283055 |
Joint lock | 12.09 | 9.91 | 42 | 397382 | 2029 | 46286609 |
Skin discolouration | 12.06 | 9.91 | 364 | 397060 | 32316 | 46256322 |
Alcohol interaction | 12.00 | 9.91 | 3 | 397421 | 2442 | 46286196 |
Drug ineffective | 11.97 | 9.91 | 6143 | 391281 | 671695 | 45616943 |
Acute respiratory distress syndrome | 11.93 | 9.91 | 124 | 397300 | 21798 | 46266840 |
Joint range of motion decreased | 11.93 | 9.91 | 188 | 397236 | 14936 | 46273702 |
Hyperbilirubinaemia | 11.93 | 9.91 | 47 | 397377 | 10391 | 46278247 |
Upper limb fracture | 11.90 | 9.91 | 194 | 397230 | 15519 | 46273119 |
Carcinoma in situ of skin | 11.89 | 9.91 | 12 | 397412 | 214 | 46288424 |
Renal mass | 11.86 | 9.91 | 38 | 397386 | 1760 | 46286878 |
Dermatitis bullous | 11.84 | 9.91 | 30 | 397394 | 7613 | 46281025 |
Treatment failure | 11.82 | 9.91 | 933 | 396491 | 92154 | 46196484 |
Atrial fibrillation | 11.75 | 9.91 | 742 | 396682 | 102848 | 46185790 |
Creatinine renal clearance decreased | 11.64 | 9.91 | 26 | 397398 | 6894 | 46281744 |
Bundle branch block left | 11.64 | 9.91 | 23 | 397401 | 6376 | 46282262 |
Cholestasis of pregnancy | 11.63 | 9.91 | 28 | 397396 | 1096 | 46287542 |
Nightmare | 11.63 | 9.91 | 88 | 397336 | 16510 | 46272128 |
Complication of device insertion | 11.61 | 9.91 | 15 | 397409 | 4929 | 46283709 |
Induced labour | 11.59 | 9.91 | 25 | 397399 | 909 | 46287729 |
Cystitis haemorrhagic | 11.57 | 9.91 | 8 | 397416 | 3539 | 46285099 |
Colitis microscopic | 11.56 | 9.91 | 24 | 397400 | 6532 | 46282106 |
Arthritis bacterial | 11.51 | 9.91 | 86 | 397338 | 5650 | 46282988 |
Aspiration | 11.48 | 9.91 | 42 | 397382 | 9489 | 46279149 |
Body temperature fluctuation | 11.46 | 9.91 | 38 | 397386 | 1792 | 46286846 |
Talipes | 11.43 | 9.91 | 32 | 397392 | 1375 | 46287263 |
Hyperammonaemia | 11.40 | 9.91 | 14 | 397410 | 4702 | 46283936 |
Coronary arterial stent insertion | 11.39 | 9.91 | 5 | 397419 | 2848 | 46285790 |
Sudden death | 11.37 | 9.91 | 42 | 397382 | 9462 | 46279176 |
Electrocardiogram QRS complex prolonged | 11.35 | 9.91 | 18 | 397406 | 5431 | 46283207 |
Renal tubular necrosis | 11.33 | 9.91 | 50 | 397374 | 10709 | 46277929 |
Red blood cell count | 11.32 | 9.91 | 3 | 397421 | 0 | 46288638 |
Vasa praevia | 11.32 | 9.91 | 3 | 397421 | 0 | 46288638 |
Shigella infection | 11.32 | 9.91 | 3 | 397421 | 0 | 46288638 |
Angina pectoris | 11.32 | 9.91 | 160 | 397264 | 26615 | 46262023 |
Kidney transplant rejection | 11.31 | 9.91 | 11 | 397413 | 4107 | 46284531 |
Leukocytosis | 11.29 | 9.91 | 136 | 397288 | 23262 | 46265376 |
Rotator cuff repair | 11.28 | 9.91 | 33 | 397391 | 1454 | 46287184 |
Respiratory acidosis | 11.27 | 9.91 | 22 | 397402 | 6126 | 46282512 |
Wrong technique in product usage process | 11.26 | 9.91 | 365 | 397059 | 54057 | 46234581 |
Hepatitis C | 11.25 | 9.91 | 23 | 397401 | 6295 | 46282343 |
Bone disorder | 11.22 | 9.91 | 236 | 397188 | 19797 | 46268841 |
Mean cell volume increased | 11.21 | 9.91 | 51 | 397373 | 2793 | 46285845 |
Sinus congestion | 11.13 | 9.91 | 165 | 397259 | 12944 | 46275694 |
Bite | 11.12 | 9.91 | 15 | 397409 | 369 | 46288269 |
Animal bite | 11.03 | 9.91 | 44 | 397380 | 2273 | 46286365 |
Mycobacterium tuberculosis complex test positive | 11.01 | 9.91 | 34 | 397390 | 1544 | 46287094 |
Naevus flammeus | 10.97 | 9.91 | 9 | 397415 | 121 | 46288517 |
Large intestinal stenosis | 10.95 | 9.91 | 37 | 397387 | 1762 | 46286876 |
Bundle branch block right | 10.93 | 9.91 | 15 | 397409 | 4804 | 46283834 |
Bladder disorder | 10.92 | 9.91 | 100 | 397324 | 6978 | 46281660 |
Fracture delayed union | 10.84 | 9.91 | 42 | 397382 | 2140 | 46286498 |
Spinal osteoarthritis | 10.82 | 9.91 | 175 | 397249 | 13976 | 46274662 |
Myocardial ischaemia | 10.73 | 9.91 | 64 | 397360 | 12685 | 46275953 |
Gastrointestinal inflammation | 10.71 | 9.91 | 68 | 397356 | 4233 | 46284405 |
Chondropathy | 10.69 | 9.91 | 39 | 397385 | 1931 | 46286707 |
Hepatitis fulminant | 10.67 | 9.91 | 8 | 397416 | 3394 | 46285244 |
Angina unstable | 10.66 | 9.91 | 31 | 397393 | 7517 | 46281121 |
Haemorrhage intracranial | 10.64 | 9.91 | 64 | 397360 | 12660 | 46275978 |
Gait disturbance | 10.64 | 9.91 | 1402 | 396022 | 143861 | 46144777 |
Human antichimeric antibody positive | 10.61 | 9.91 | 31 | 397393 | 1365 | 46287273 |
Hallucination, visual | 10.61 | 9.91 | 99 | 397325 | 17774 | 46270864 |
Tubulointerstitial nephritis | 10.55 | 9.91 | 78 | 397346 | 14710 | 46273928 |
Foetal anticonvulsant syndrome | 10.54 | 9.91 | 16 | 397408 | 440 | 46288198 |
Catheter site erythema | 10.52 | 9.91 | 11 | 397413 | 3972 | 46284666 |
Joint warmth | 10.47 | 9.91 | 29 | 397395 | 1238 | 46287400 |
Muscle rupture | 10.47 | 9.91 | 40 | 397384 | 2025 | 46286613 |
Neutropenic colitis | 10.46 | 9.91 | 3 | 397421 | 2229 | 46286409 |
Fluid retention | 10.41 | 9.91 | 343 | 397081 | 50703 | 46237935 |
Temperature regulation disorder | 10.41 | 9.91 | 8 | 397416 | 3352 | 46285286 |
Spondylitis | 10.41 | 9.91 | 39 | 397385 | 1956 | 46286682 |
Blood folate increased | 10.39 | 9.91 | 9 | 397415 | 131 | 46288507 |
Atrioventricular block | 10.35 | 9.91 | 27 | 397397 | 6784 | 46281854 |
Complication of pregnancy | 10.33 | 9.91 | 17 | 397407 | 502 | 46288136 |
Diabetes mellitus | 10.31 | 9.91 | 336 | 397088 | 49729 | 46238909 |
Pulmonary toxicity | 10.26 | 9.91 | 15 | 397409 | 4678 | 46283960 |
Decreased appetite | 10.24 | 9.91 | 1470 | 395954 | 192366 | 46096272 |
Hospitalisation | 10.24 | 9.91 | 438 | 396986 | 62947 | 46225691 |
Squamous cell carcinoma of skin | 10.23 | 9.91 | 77 | 397347 | 5070 | 46283568 |
Lupus-like syndrome | 10.23 | 9.91 | 107 | 397317 | 7737 | 46280901 |
Lung neoplasm malignant | 10.20 | 9.91 | 187 | 397237 | 15302 | 46273336 |
Neck pain | 10.18 | 9.91 | 572 | 396852 | 54734 | 46233904 |
Potentiating drug interaction | 10.18 | 9.91 | 11 | 397413 | 3912 | 46284726 |
Skin infection | 10.13 | 9.91 | 144 | 397280 | 11195 | 46277443 |
Paranoia | 10.13 | 9.91 | 51 | 397373 | 10546 | 46278092 |
Endodontic procedure | 10.12 | 9.91 | 45 | 397379 | 2440 | 46286198 |
Treatment noncompliance | 10.12 | 9.91 | 185 | 397239 | 29546 | 46259092 |
Anterior chamber cleavage syndrome | 10.11 | 9.91 | 10 | 397414 | 174 | 46288464 |
Personality disorder | 10.07 | 9.91 | 53 | 397371 | 3080 | 46285558 |
Diabetes insipidus | 10.05 | 9.91 | 3 | 397421 | 2171 | 46286467 |
Intervertebral disc protrusion | 10.04 | 9.91 | 236 | 397188 | 20169 | 46268469 |
Injection site extravasation | 10.03 | 9.91 | 95 | 397329 | 6690 | 46281948 |
Therapy interrupted | 10.03 | 9.91 | 138 | 397286 | 10653 | 46277985 |
Acute pulmonary oedema | 10.02 | 9.91 | 34 | 397390 | 7857 | 46280781 |
Liver transplant | 10.02 | 9.91 | 4 | 397420 | 2413 | 46286225 |
Lymphadenectomy | 10.01 | 9.91 | 23 | 397401 | 873 | 46287765 |
Hypoaesthesia | 9.97 | 9.91 | 1157 | 396267 | 117712 | 46170926 |
Sickle cell anaemia | 9.96 | 9.91 | 18 | 397406 | 574 | 46288064 |
Hysterectomy | 9.95 | 9.91 | 106 | 397318 | 7700 | 46280938 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug abuse | 391.60 | 10.24 | 24 | 177801 | 82048 | 29692605 |
Toxicity to various agents | 355.01 | 10.24 | 318 | 177507 | 176865 | 29597788 |
Completed suicide | 332.05 | 10.24 | 90 | 177735 | 99402 | 29675251 |
Rheumatoid arthritis | 320.10 | 10.24 | 736 | 177089 | 40461 | 29734192 |
Drug interaction | 204.00 | 10.24 | 563 | 177262 | 199005 | 29575648 |
Arthralgia | 184.33 | 10.24 | 1408 | 176417 | 134383 | 29640270 |
Foetal exposure during pregnancy | 141.34 | 10.24 | 511 | 177314 | 36360 | 29738293 |
Acute kidney injury | 113.74 | 10.24 | 1059 | 176766 | 272783 | 29501870 |
Overdose | 108.47 | 10.24 | 210 | 177615 | 84127 | 29690526 |
Fatigue | 88.41 | 10.24 | 2509 | 175316 | 318164 | 29456489 |
Psoriatic arthropathy | 87.37 | 10.24 | 248 | 177577 | 15513 | 29759140 |
Intentional overdose | 87.05 | 10.24 | 71 | 177754 | 41410 | 29733243 |
Joint swelling | 86.32 | 10.24 | 525 | 177300 | 46421 | 29728232 |
Nasopharyngitis | 81.77 | 10.24 | 614 | 177211 | 58235 | 29716418 |
Blood pressure fluctuation | 79.70 | 10.24 | 257 | 177568 | 17246 | 29757407 |
Sickle cell anaemia with crisis | 77.47 | 10.24 | 83 | 177742 | 2319 | 29772334 |
Coma | 74.50 | 10.24 | 78 | 177747 | 40371 | 29734282 |
Drug reaction with eosinophilia and systemic symptoms | 74.44 | 10.24 | 38 | 177787 | 28450 | 29746203 |
Enthesopathy | 71.03 | 10.24 | 87 | 177738 | 2819 | 29771834 |
Cardiac arrest | 64.13 | 10.24 | 308 | 177517 | 92542 | 29682111 |
Suicide attempt | 60.84 | 10.24 | 77 | 177748 | 36620 | 29738033 |
Rhabdomyolysis | 57.83 | 10.24 | 189 | 177636 | 63391 | 29711262 |
Premature baby | 57.02 | 10.24 | 223 | 177602 | 16468 | 29758185 |
Pain | 56.67 | 10.24 | 1383 | 176442 | 171258 | 29603395 |
Respiratory arrest | 56.65 | 10.24 | 54 | 177771 | 29204 | 29745449 |
Exposure during pregnancy | 56.56 | 10.24 | 151 | 177674 | 9110 | 29765543 |
Peripheral swelling | 54.71 | 10.24 | 579 | 177246 | 60495 | 29714158 |
Atrial septal defect | 53.40 | 10.24 | 121 | 177704 | 6580 | 29768073 |
Haemoglobin decreased | 52.71 | 10.24 | 961 | 176864 | 113137 | 29661516 |
Neonatal respiratory distress syndrome | 52.15 | 10.24 | 89 | 177736 | 3923 | 29770730 |
Intentional product misuse | 51.22 | 10.24 | 79 | 177746 | 34588 | 29740065 |
Full blood count decreased | 49.70 | 10.24 | 205 | 177620 | 15512 | 29759141 |
Tenosynovitis | 48.38 | 10.24 | 80 | 177745 | 3435 | 29771218 |
Musculoskeletal stiffness | 47.37 | 10.24 | 370 | 177455 | 35511 | 29739142 |
Serotonin syndrome | 46.54 | 10.24 | 24 | 177801 | 17867 | 29756786 |
Febrile neutropenia | 46.10 | 10.24 | 408 | 177417 | 106285 | 29668368 |
Product use in unapproved indication | 46.04 | 10.24 | 253 | 177572 | 73440 | 29701213 |
Multiple organ dysfunction syndrome | 45.94 | 10.24 | 207 | 177618 | 63280 | 29711373 |
Drug dependence | 45.23 | 10.24 | 36 | 177789 | 21259 | 29753394 |
Weight decreased | 45.08 | 10.24 | 1194 | 176631 | 149727 | 29624926 |
Sopor | 44.94 | 10.24 | 6 | 177819 | 10985 | 29763668 |
Bradycardia | 44.27 | 10.24 | 219 | 177606 | 65307 | 29709346 |
Renal failure | 43.10 | 10.24 | 524 | 177301 | 128442 | 29646211 |
Skin cancer | 42.88 | 10.24 | 124 | 177701 | 7837 | 29766816 |
Pain in extremity | 42.36 | 10.24 | 903 | 176922 | 109318 | 29665335 |
Maternal drugs affecting foetus | 40.76 | 10.24 | 83 | 177742 | 4190 | 29770463 |
Fall | 40.34 | 10.24 | 1387 | 176438 | 180485 | 29594168 |
Cytomegalovirus infection | 39.94 | 10.24 | 49 | 177776 | 23625 | 29751028 |
Angioedema | 39.65 | 10.24 | 91 | 177734 | 34293 | 29740360 |
Hepatic function abnormal | 39.31 | 10.24 | 123 | 177702 | 41822 | 29732831 |
Hypospadias | 38.26 | 10.24 | 62 | 177763 | 2617 | 29772036 |
Lactic acidosis | 38.14 | 10.24 | 80 | 177745 | 31133 | 29743520 |
Drug resistance | 38 | 10.24 | 38 | 177787 | 20095 | 29754558 |
Small for dates baby | 37.59 | 10.24 | 68 | 177757 | 3140 | 29771513 |
Maternal exposure during breast feeding | 36.91 | 10.24 | 47 | 177778 | 1585 | 29773068 |
Pneumonia | 36.69 | 10.24 | 2376 | 175449 | 331930 | 29442723 |
Arthritis | 36.39 | 10.24 | 259 | 177566 | 24142 | 29750511 |
Back pain | 36.08 | 10.24 | 830 | 176995 | 101766 | 29672887 |
Blood pressure increased | 35.37 | 10.24 | 612 | 177213 | 71316 | 29703337 |
Poisoning | 34.84 | 10.24 | 12 | 177813 | 11370 | 29763283 |
Hepatic failure | 34.67 | 10.24 | 96 | 177729 | 33947 | 29740706 |
Agitation | 34.67 | 10.24 | 184 | 177641 | 53889 | 29720764 |
Vitamin B12 deficiency | 34.14 | 10.24 | 58 | 177767 | 2547 | 29772106 |
Influenza | 33.65 | 10.24 | 400 | 177425 | 42998 | 29731655 |
Maternal exposure during pregnancy | 33.21 | 10.24 | 72 | 177753 | 3799 | 29770854 |
Basal cell carcinoma | 32.95 | 10.24 | 185 | 177640 | 15883 | 29758770 |
Osteoarthritis | 32.94 | 10.24 | 204 | 177621 | 18145 | 29756508 |
Drug intolerance | 32.76 | 10.24 | 412 | 177413 | 44879 | 29729774 |
Drug withdrawal syndrome | 32.38 | 10.24 | 42 | 177783 | 19767 | 29754886 |
Tongue disorder | 32.19 | 10.24 | 76 | 177749 | 4246 | 29770407 |
Cardiac failure | 32.18 | 10.24 | 328 | 177497 | 83090 | 29691563 |
Dysmorphism | 32.02 | 10.24 | 49 | 177776 | 1968 | 29772685 |
Ventricular septal defect | 31.84 | 10.24 | 67 | 177758 | 3462 | 29771191 |
Hypoglycaemia neonatal | 31.79 | 10.24 | 43 | 177782 | 1540 | 29773113 |
Asthenia | 31.18 | 10.24 | 1609 | 176216 | 219681 | 29554972 |
Suicidal ideation | 31.02 | 10.24 | 110 | 177715 | 36004 | 29738649 |
Synovitis | 30.45 | 10.24 | 127 | 177698 | 9656 | 29764997 |
Respiratory failure | 30.25 | 10.24 | 418 | 177407 | 100224 | 29674429 |
Infusion related reaction | 30.19 | 10.24 | 371 | 177454 | 40193 | 29734460 |
Urinary tract infection | 30.08 | 10.24 | 609 | 177216 | 73050 | 29701603 |
Psoriasis | 30.03 | 10.24 | 385 | 177440 | 42121 | 29732532 |
Blood pressure systolic increased | 29.69 | 10.24 | 172 | 177653 | 14938 | 29759715 |
Low birth weight baby | 29.29 | 10.24 | 91 | 177734 | 5985 | 29768668 |
Pathogen resistance | 29.18 | 10.24 | 7 | 177818 | 8403 | 29766250 |
Hypoglycaemia | 28.65 | 10.24 | 181 | 177644 | 50800 | 29723853 |
Arthropathy | 28.61 | 10.24 | 216 | 177609 | 20511 | 29754142 |
Syndactyly | 28.32 | 10.24 | 28 | 177797 | 710 | 29773943 |
Product dose omission issue | 28.20 | 10.24 | 728 | 177097 | 90903 | 29683750 |
Infective pulmonary exacerbation of cystic fibrosis | 28.09 | 10.24 | 8 | 177817 | 8564 | 29766089 |
Musculoskeletal pain | 27.53 | 10.24 | 293 | 177532 | 30647 | 29744006 |
Depressed level of consciousness | 27.41 | 10.24 | 125 | 177700 | 38097 | 29736556 |
Intentional self-injury | 27.35 | 10.24 | 24 | 177801 | 13508 | 29761145 |
Immune reconstitution inflammatory syndrome | 27.17 | 10.24 | 10 | 177815 | 9091 | 29765562 |
Aggression | 26.89 | 10.24 | 120 | 177705 | 36787 | 29737866 |
Joint range of motion decreased | 26.76 | 10.24 | 86 | 177739 | 5759 | 29768894 |
Death | 26.60 | 10.24 | 1796 | 176029 | 355487 | 29419166 |
Delirium | 26.18 | 10.24 | 138 | 177687 | 40493 | 29734160 |
Substance abuse | 26.18 | 10.24 | 5 | 177820 | 7035 | 29767618 |
Haemangioma congenital | 26.05 | 10.24 | 23 | 177802 | 503 | 29774150 |
Palmar-plantar erythrodysaesthesia syndrome | 25.91 | 10.24 | 30 | 177795 | 14840 | 29759813 |
Cryptorchism | 25.59 | 10.24 | 40 | 177785 | 1637 | 29773016 |
Back disorder | 25.48 | 10.24 | 86 | 177739 | 5908 | 29768745 |
Poor venous access | 24.64 | 10.24 | 49 | 177776 | 2431 | 29772222 |
Large for dates baby | 24.49 | 10.24 | 28 | 177797 | 842 | 29773811 |
C-reactive protein abnormal | 24.44 | 10.24 | 81 | 177744 | 5512 | 29769141 |
Altered state of consciousness | 24.38 | 10.24 | 51 | 177774 | 19868 | 29754785 |
Hyperbilirubinaemia neonatal | 24.32 | 10.24 | 25 | 177800 | 665 | 29773988 |
Hyperglycaemia | 24.14 | 10.24 | 117 | 177708 | 35083 | 29739570 |
Pyrexia | 24.01 | 10.24 | 1468 | 176357 | 293021 | 29481632 |
Drug-induced liver injury | 23.97 | 10.24 | 57 | 177768 | 21217 | 29753436 |
Injection site pain | 23.77 | 10.24 | 280 | 177545 | 30030 | 29744623 |
Renal impairment | 23.76 | 10.24 | 354 | 177471 | 83830 | 29690823 |
Foetal anticonvulsant syndrome | 23.66 | 10.24 | 26 | 177799 | 748 | 29773905 |
Vitamin B12 decreased | 23.55 | 10.24 | 30 | 177795 | 1012 | 29773641 |
Exposure via breast milk | 23.30 | 10.24 | 37 | 177788 | 1535 | 29773118 |
Knee arthroplasty | 23.25 | 10.24 | 80 | 177745 | 5550 | 29769103 |
Psychotic disorder | 23.17 | 10.24 | 59 | 177766 | 21456 | 29753197 |
Cellulitis | 22.96 | 10.24 | 398 | 177427 | 46386 | 29728267 |
Lower respiratory tract infection | 22.85 | 10.24 | 251 | 177574 | 26463 | 29748190 |
Off label use | 22.60 | 10.24 | 1230 | 176595 | 248060 | 29526593 |
Neurotoxicity | 22.53 | 10.24 | 27 | 177798 | 13155 | 29761498 |
Cataract | 22.43 | 10.24 | 213 | 177612 | 21622 | 29753031 |
Electrocardiogram QT prolonged | 22.38 | 10.24 | 123 | 177702 | 35712 | 29738941 |
Sinusitis | 22.29 | 10.24 | 299 | 177526 | 33046 | 29741607 |
Agranulocytosis | 22.25 | 10.24 | 62 | 177763 | 21880 | 29752773 |
Medical device implantation | 21.84 | 10.24 | 21 | 177804 | 514 | 29774139 |
Intestinal stenosis | 21.84 | 10.24 | 40 | 177785 | 1865 | 29772788 |
Blood iron decreased | 21.83 | 10.24 | 63 | 177762 | 3977 | 29770676 |
Body temperature decreased | 21.71 | 10.24 | 114 | 177711 | 9541 | 29765112 |
Pulmonary fibrosis | 21.60 | 10.24 | 165 | 177660 | 15725 | 29758928 |
Loss of personal independence in daily activities | 21.59 | 10.24 | 209 | 177616 | 21326 | 29753327 |
Acute hepatic failure | 21.55 | 10.24 | 23 | 177802 | 11804 | 29762849 |
Post transplant lymphoproliferative disorder | 21.45 | 10.24 | 3 | 177822 | 5303 | 29769350 |
Shock | 21.43 | 10.24 | 67 | 177758 | 22792 | 29751861 |
Rheumatoid nodule | 21.32 | 10.24 | 37 | 177788 | 1653 | 29773000 |
Red blood cell count decreased | 21.02 | 10.24 | 244 | 177581 | 26077 | 29748576 |
Neck mass | 20.90 | 10.24 | 33 | 177792 | 1362 | 29773291 |
Frequent bowel movements | 20.83 | 10.24 | 102 | 177723 | 8303 | 29766350 |
Congenital oesophageal anomaly | 20.72 | 10.24 | 11 | 177814 | 99 | 29774554 |
Kidney infection | 20.63 | 10.24 | 67 | 177758 | 4511 | 29770142 |
Anaphylactic shock | 20.55 | 10.24 | 32 | 177793 | 13961 | 29760692 |
Alanine aminotransferase abnormal | 20.54 | 10.24 | 47 | 177778 | 2572 | 29772081 |
Congenital hand malformation | 20.38 | 10.24 | 19 | 177806 | 447 | 29774206 |
Blood pressure systolic abnormal | 20.34 | 10.24 | 34 | 177791 | 1473 | 29773180 |
Toxic epidermal necrolysis | 20.26 | 10.24 | 48 | 177777 | 17892 | 29756761 |
Heart rate decreased | 20.19 | 10.24 | 202 | 177623 | 20792 | 29753861 |
Somnolence | 19.98 | 10.24 | 430 | 177395 | 96333 | 29678320 |
Sedation | 19.97 | 10.24 | 42 | 177783 | 16331 | 29758322 |
Gamma-glutamyltransferase increased | 19.86 | 10.24 | 98 | 177727 | 29252 | 29745401 |
Post procedural infection | 19.79 | 10.24 | 66 | 177759 | 4506 | 29770147 |
Thrombocytopenia | 19.61 | 10.24 | 642 | 177183 | 136402 | 29638251 |
Rash maculo-papular | 19.52 | 10.24 | 81 | 177744 | 25337 | 29749316 |
Anal fistula | 19.49 | 10.24 | 60 | 177765 | 3926 | 29770727 |
Hypertriglyceridaemia | 19.43 | 10.24 | 12 | 177813 | 8086 | 29766567 |
Pancytopenia | 19.40 | 10.24 | 651 | 177174 | 84401 | 29690252 |
Faecal calprotectin increased | 19.34 | 10.24 | 29 | 177796 | 1144 | 29773509 |
Proteinuria | 19.20 | 10.24 | 42 | 177783 | 16103 | 29758550 |
Juvenile idiopathic arthritis | 18.95 | 10.24 | 27 | 177798 | 1016 | 29773637 |
Throat lesion | 18.93 | 10.24 | 10 | 177815 | 89 | 29774564 |
Hypoaesthesia | 18.81 | 10.24 | 438 | 177387 | 53792 | 29720861 |
Osteonecrosis of jaw | 18.59 | 10.24 | 53 | 177772 | 18565 | 29756088 |
Venoocclusive liver disease | 18.54 | 10.24 | 8 | 177817 | 6605 | 29768048 |
Hepatic encephalopathy | 18.52 | 10.24 | 35 | 177790 | 14157 | 29760496 |
Tachycardia | 18.49 | 10.24 | 317 | 177508 | 73422 | 29701231 |
Blood creatine phosphokinase increased | 18.33 | 10.24 | 169 | 177656 | 43679 | 29730974 |
Asthma | 18.05 | 10.24 | 133 | 177692 | 36041 | 29738612 |
Medication error | 17.93 | 10.24 | 64 | 177761 | 20908 | 29753745 |
Acute respiratory distress syndrome | 17.90 | 10.24 | 75 | 177750 | 23397 | 29751256 |
Cardio-respiratory arrest | 17.57 | 10.24 | 237 | 177588 | 57069 | 29717584 |
Ventricular fibrillation | 17.50 | 10.24 | 40 | 177785 | 15098 | 29759555 |
Incorrect route of product administration | 17.47 | 10.24 | 25 | 177800 | 11290 | 29763363 |
Cytokine release syndrome | 17.35 | 10.24 | 20 | 177805 | 9913 | 29764740 |
Hyperkalaemia | 17.13 | 10.24 | 282 | 177543 | 65728 | 29708925 |
Bradycardia neonatal | 17.07 | 10.24 | 24 | 177801 | 892 | 29773761 |
Neuropathy peripheral | 16.73 | 10.24 | 542 | 177283 | 69933 | 29704720 |
Hypokalaemia | 16.71 | 10.24 | 204 | 177621 | 49988 | 29724665 |
Hepatocellular injury | 16.69 | 10.24 | 86 | 177739 | 25385 | 29749268 |
Localised infection | 16.68 | 10.24 | 139 | 177686 | 13598 | 29761055 |
Increased tendency to bruise | 16.68 | 10.24 | 53 | 177772 | 3528 | 29771125 |
Blood test abnormal | 16.63 | 10.24 | 71 | 177754 | 5454 | 29769199 |
Talipes | 16.53 | 10.24 | 33 | 177792 | 1642 | 29773011 |
Agitation neonatal | 16.41 | 10.24 | 25 | 177800 | 1000 | 29773653 |
Selective eating disorder | 16.41 | 10.24 | 33 | 177792 | 1651 | 29773002 |
Caesarean section | 16.38 | 10.24 | 38 | 177787 | 2099 | 29772554 |
Hyperbilirubinaemia | 16.35 | 10.24 | 49 | 177776 | 16893 | 29757760 |
Aspergillus infection | 16.34 | 10.24 | 22 | 177803 | 10192 | 29764461 |
Balance disorder | 16.33 | 10.24 | 306 | 177519 | 36187 | 29738466 |
Injection site erythema | 16.28 | 10.24 | 139 | 177686 | 13695 | 29760958 |
Metabolic acidosis | 16.27 | 10.24 | 143 | 177682 | 37318 | 29737335 |
Disseminated intravascular coagulation | 16.20 | 10.24 | 72 | 177753 | 22099 | 29752554 |
Accidental overdose | 16.14 | 10.24 | 55 | 177770 | 18220 | 29756433 |
Tendonitis | 16.13 | 10.24 | 92 | 177733 | 7944 | 29766709 |
Vitamin D decreased | 16.10 | 10.24 | 43 | 177782 | 2594 | 29772059 |
Intestinal resection | 16.05 | 10.24 | 30 | 177795 | 1421 | 29773232 |
Contusion | 16.03 | 10.24 | 268 | 177557 | 31012 | 29743641 |
Immunodeficiency | 16.01 | 10.24 | 59 | 177766 | 4235 | 29770418 |
Vitamin D deficiency | 16 | 10.24 | 67 | 177758 | 5103 | 29769550 |
Ventricular tachycardia | 15.96 | 10.24 | 80 | 177745 | 23782 | 29750871 |
Cholestasis | 15.93 | 10.24 | 85 | 177740 | 24865 | 29749788 |
Wound | 15.87 | 10.24 | 127 | 177698 | 12275 | 29762378 |
Ankylosing spondylitis | 15.82 | 10.24 | 61 | 177764 | 4473 | 29770180 |
Vomiting | 15.63 | 10.24 | 1109 | 176716 | 218709 | 29555944 |
Arthritis bacterial | 15.53 | 10.24 | 60 | 177765 | 4404 | 29770249 |
Lacrimal disorder | 15.42 | 10.24 | 14 | 177811 | 318 | 29774335 |
Stevens-Johnson syndrome | 15.39 | 10.24 | 53 | 177772 | 17503 | 29757150 |
Injection site bruising | 15.38 | 10.24 | 85 | 177740 | 7253 | 29767400 |
Injection site swelling | 15.37 | 10.24 | 97 | 177728 | 8683 | 29765970 |
Drug eruption | 15.31 | 10.24 | 53 | 177772 | 17473 | 29757180 |
Erythema multiforme | 15.15 | 10.24 | 15 | 177810 | 7970 | 29766683 |
Acute graft versus host disease | 15.05 | 10.24 | 8 | 177817 | 5856 | 29768797 |
Drug level increased | 15.04 | 10.24 | 57 | 177768 | 18297 | 29756356 |
Eosinophilia | 14.99 | 10.24 | 74 | 177751 | 22086 | 29752567 |
Brain oedema | 14.96 | 10.24 | 32 | 177793 | 12366 | 29762287 |
Product quality issue | 14.94 | 10.24 | 59 | 177766 | 18715 | 29755938 |
Hepatitis | 14.93 | 10.24 | 75 | 177750 | 22281 | 29752372 |
Nephrolithiasis | 14.78 | 10.24 | 218 | 177607 | 24592 | 29750061 |
Hypermobility syndrome | 14.74 | 10.24 | 12 | 177813 | 234 | 29774419 |
Infection | 14.73 | 10.24 | 585 | 177240 | 77489 | 29697164 |
Status epilepticus | 14.71 | 10.24 | 27 | 177798 | 11045 | 29763608 |
Hypotension | 14.56 | 10.24 | 1010 | 176815 | 199555 | 29575098 |
Intestinal obstruction | 14.41 | 10.24 | 176 | 177649 | 19036 | 29755617 |
Congenital bladder anomaly | 14.40 | 10.24 | 13 | 177812 | 293 | 29774360 |
Renal injury | 14.38 | 10.24 | 30 | 177795 | 11699 | 29762954 |
Mania | 14.36 | 10.24 | 20 | 177805 | 9134 | 29765519 |
Joint stiffness | 14.32 | 10.24 | 100 | 177725 | 9261 | 29765392 |
Dermatitis acneiform | 14.26 | 10.24 | 8 | 177817 | 5681 | 29768972 |
Finger deformity | 14.22 | 10.24 | 23 | 177802 | 969 | 29773684 |
Joint effusion | 14.22 | 10.24 | 51 | 177774 | 3612 | 29771041 |
Serum ferritin increased | 14.21 | 10.24 | 67 | 177758 | 5370 | 29769283 |
Neck pain | 14.07 | 10.24 | 188 | 177637 | 20756 | 29753897 |
Pancreatitis acute | 14.04 | 10.24 | 92 | 177733 | 25603 | 29749050 |
Hand deformity | 14.02 | 10.24 | 33 | 177792 | 1840 | 29772813 |
Hypoxia | 13.92 | 10.24 | 200 | 177625 | 47654 | 29726999 |
Saliva altered | 13.84 | 10.24 | 10 | 177815 | 162 | 29774491 |
Speech disorder developmental | 13.83 | 10.24 | 25 | 177800 | 1154 | 29773499 |
Jaundice neonatal | 13.82 | 10.24 | 24 | 177801 | 1073 | 29773580 |
Akathisia | 13.82 | 10.24 | 9 | 177816 | 5895 | 29768758 |
Blood insulin increased | 13.81 | 10.24 | 14 | 177811 | 366 | 29774287 |
Neuroleptic malignant syndrome | 13.75 | 10.24 | 50 | 177775 | 16245 | 29758408 |
Prostate cancer | 13.68 | 10.24 | 209 | 177616 | 23748 | 29750905 |
Multiple congenital abnormalities | 13.64 | 10.24 | 16 | 177809 | 495 | 29774158 |
Accessory spleen | 13.63 | 10.24 | 10 | 177815 | 166 | 29774487 |
Hepatitis C | 13.62 | 10.24 | 37 | 177788 | 13168 | 29761485 |
Diabetic ketoacidosis | 13.52 | 10.24 | 49 | 177776 | 15937 | 29758716 |
Pernicious anaemia | 13.48 | 10.24 | 8 | 177817 | 91 | 29774562 |
Cleft lip | 13.46 | 10.24 | 13 | 177812 | 320 | 29774333 |
Seizure | 13.45 | 10.24 | 464 | 177361 | 98011 | 29676642 |
Weight decrease neonatal | 13.33 | 10.24 | 13 | 177812 | 324 | 29774329 |
Fistula | 13.30 | 10.24 | 63 | 177762 | 5059 | 29769594 |
Acoustic neuroma | 13.27 | 10.24 | 9 | 177816 | 131 | 29774522 |
Adverse drug reaction | 13.25 | 10.24 | 202 | 177623 | 22943 | 29751710 |
Myocardial infarction | 13.25 | 10.24 | 610 | 177215 | 125015 | 29649638 |
Hepatotoxicity | 13.21 | 10.24 | 59 | 177766 | 18086 | 29756567 |
Hepatocellular carcinoma | 13.16 | 10.24 | 23 | 177802 | 9587 | 29765066 |
Ankyloglossia congenital | 13.02 | 10.24 | 12 | 177813 | 278 | 29774375 |
Pulmonary alveolar haemorrhage | 12.91 | 10.24 | 12 | 177813 | 6569 | 29768084 |
Grip strength decreased | 12.89 | 10.24 | 35 | 177790 | 2133 | 29772520 |
Skin lesion | 12.84 | 10.24 | 167 | 177658 | 18327 | 29756326 |
Transaminases increased | 12.81 | 10.24 | 84 | 177741 | 23373 | 29751280 |
Polyhydramnios | 12.79 | 10.24 | 11 | 177814 | 232 | 29774421 |
Malignant neoplasm progression | 12.75 | 10.24 | 329 | 177496 | 71958 | 29702695 |
Squamous cell carcinoma of skin | 12.67 | 10.24 | 95 | 177730 | 9000 | 29765653 |
Urticaria | 12.66 | 10.24 | 238 | 177587 | 54368 | 29720285 |
Transplant rejection | 12.64 | 10.24 | 22 | 177803 | 9184 | 29765469 |
Double stranded DNULL antibody positive | 12.63 | 10.24 | 8 | 177817 | 103 | 29774550 |
Foot deformity | 12.62 | 10.24 | 47 | 177778 | 3390 | 29771263 |
Nerve compression | 12.62 | 10.24 | 41 | 177784 | 2761 | 29771892 |
Folate deficiency | 12.61 | 10.24 | 22 | 177803 | 987 | 29773666 |
Vascular insufficiency | 12.58 | 10.24 | 13 | 177812 | 348 | 29774305 |
Arthrodesis | 12.57 | 10.24 | 14 | 177811 | 409 | 29774244 |
Cerebral microangiopathy | 12.50 | 10.24 | 10 | 177815 | 190 | 29774463 |
Exostosis | 12.48 | 10.24 | 47 | 177778 | 3408 | 29771245 |
Hypocalcaemia | 12.47 | 10.24 | 75 | 177750 | 21301 | 29753352 |
Intervertebral disc protrusion | 12.45 | 10.24 | 96 | 177729 | 9175 | 29765478 |
Malignant melanoma | 12.44 | 10.24 | 81 | 177744 | 7330 | 29767323 |
Gait apraxia | 12.40 | 10.24 | 3 | 177822 | 0 | 29774653 |
Hepatitis fulminant | 12.33 | 10.24 | 4 | 177821 | 3937 | 29770716 |
Peripheral artery thrombosis | 12.25 | 10.24 | 35 | 177790 | 2197 | 29772456 |
Bronchopulmonary aspergillosis | 12.24 | 10.24 | 35 | 177790 | 12249 | 29762404 |
Fear | 12.19 | 10.24 | 29 | 177796 | 10796 | 29763857 |
Spinal disorder | 12.19 | 10.24 | 46 | 177779 | 3339 | 29771314 |
Acute generalised exanthematous pustulosis | 12.10 | 10.24 | 11 | 177814 | 6087 | 29768566 |
Ultrasound skull abnormal | 12.07 | 10.24 | 7 | 177818 | 76 | 29774577 |
Neutropenia | 12.02 | 10.24 | 632 | 177193 | 127908 | 29646745 |
Hepatic cyst | 12.02 | 10.24 | 37 | 177788 | 2421 | 29772232 |
Progressive multifocal leukoencephalopathy | 11.96 | 10.24 | 22 | 177803 | 8991 | 29765662 |
Otitis media | 11.93 | 10.24 | 38 | 177787 | 2533 | 29772120 |
Haematocrit decreased | 11.92 | 10.24 | 252 | 177573 | 30447 | 29744206 |
Foetal disorder | 11.91 | 10.24 | 17 | 177808 | 641 | 29774012 |
Endophthalmitis | 11.87 | 10.24 | 3 | 177822 | 3477 | 29771176 |
Cytomegalovirus viraemia | 11.77 | 10.24 | 10 | 177815 | 5719 | 29768934 |
Magnetic resonance imaging spinal abnormal | 11.76 | 10.24 | 7 | 177818 | 80 | 29774573 |
Nocardiosis | 11.75 | 10.24 | 3 | 177822 | 3452 | 29771201 |
Excessive cerumen production | 11.72 | 10.24 | 11 | 177814 | 261 | 29774392 |
Arthritis infective | 11.69 | 10.24 | 39 | 177786 | 2663 | 29771990 |
Septic arthritis staphylococcal | 11.69 | 10.24 | 14 | 177811 | 443 | 29774210 |
Blood creatinine increased | 11.69 | 10.24 | 434 | 177391 | 90941 | 29683712 |
Tachycardia foetal | 11.68 | 10.24 | 12 | 177813 | 319 | 29774334 |
Lipase increased | 11.67 | 10.24 | 21 | 177804 | 8655 | 29765998 |
Spinal operation | 11.64 | 10.24 | 35 | 177790 | 2261 | 29772392 |
Cystitis haemorrhagic | 11.61 | 10.24 | 7 | 177818 | 4780 | 29769873 |
Graft versus host disease | 11.59 | 10.24 | 27 | 177798 | 10123 | 29764530 |
Cerebral haemorrhage | 11.59 | 10.24 | 132 | 177693 | 32755 | 29741898 |
Foetal growth restriction | 11.52 | 10.24 | 47 | 177778 | 3538 | 29771115 |
Chronic graft versus host disease | 11.52 | 10.24 | 5 | 177820 | 4114 | 29770539 |
Renal aplasia | 11.52 | 10.24 | 17 | 177808 | 661 | 29773992 |
Ileal stenosis | 11.51 | 10.24 | 23 | 177802 | 1145 | 29773508 |
Moaning | 11.51 | 10.24 | 18 | 177807 | 737 | 29773916 |
Injection site haemorrhage | 11.49 | 10.24 | 83 | 177742 | 7772 | 29766881 |
Intellectual disability | 11.44 | 10.24 | 19 | 177806 | 819 | 29773834 |
Alcohol abuse | 11.43 | 10.24 | 9 | 177816 | 5344 | 29769309 |
Pleural fibrosis | 11.42 | 10.24 | 26 | 177799 | 1418 | 29773235 |
Oropharyngeal pain | 11.42 | 10.24 | 235 | 177590 | 28261 | 29746392 |
Rheumatoid lung | 11.41 | 10.24 | 12 | 177813 | 328 | 29774325 |
Patent ductus arteriosus | 11.36 | 10.24 | 43 | 177782 | 3126 | 29771527 |
Tonsil cancer | 11.28 | 10.24 | 18 | 177807 | 750 | 29773903 |
Pulmonary arterial hypertension | 11.22 | 10.24 | 24 | 177801 | 9277 | 29765376 |
Epstein-Barr virus infection | 11.18 | 10.24 | 14 | 177811 | 6692 | 29767961 |
Mydriasis | 11.13 | 10.24 | 12 | 177813 | 6131 | 29768522 |
BK virus infection | 11.13 | 10.24 | 6 | 177819 | 4358 | 29770295 |
Benign abdominal neoplasm | 11.13 | 10.24 | 7 | 177818 | 89 | 29774564 |
Prostatic disorder | 11.06 | 10.24 | 39 | 177786 | 2739 | 29771914 |
Umbilical hernia | 10.98 | 10.24 | 47 | 177778 | 3614 | 29771039 |
Hernia pain | 10.98 | 10.24 | 10 | 177815 | 228 | 29774425 |
Gait disturbance | 10.95 | 10.24 | 546 | 177279 | 74231 | 29700422 |
Potentiating drug interaction | 10.92 | 10.24 | 7 | 177818 | 4624 | 29770029 |
Thrombosis | 10.86 | 10.24 | 328 | 177497 | 41903 | 29732750 |
Hepatitis B | 10.85 | 10.24 | 12 | 177813 | 6060 | 29768593 |
Tubulointerstitial nephritis | 10.85 | 10.24 | 62 | 177763 | 17829 | 29756824 |
Low set ears | 10.84 | 10.24 | 13 | 177812 | 412 | 29774241 |
Cytomegalovirus chorioretinitis | 10.80 | 10.24 | 3 | 177822 | 3265 | 29771388 |
Sinus congestion | 10.78 | 10.24 | 56 | 177769 | 4666 | 29769987 |
Spinal osteoarthritis | 10.78 | 10.24 | 70 | 177755 | 6329 | 29768324 |
Physical examination abnormal | 10.74 | 10.24 | 7 | 177818 | 95 | 29774558 |
Maternal exposure timing unspecified | 10.73 | 10.24 | 12 | 177813 | 352 | 29774301 |
Adenovirus infection | 10.70 | 10.24 | 6 | 177819 | 4262 | 29770391 |
Hip fracture | 10.68 | 10.24 | 107 | 177718 | 11017 | 29763636 |
Musculoskeletal discomfort | 10.66 | 10.24 | 69 | 177756 | 6231 | 29768422 |
Mouth ulceration | 10.65 | 10.24 | 103 | 177722 | 10506 | 29764147 |
Bronchitis | 10.64 | 10.24 | 306 | 177519 | 38819 | 29735834 |
Hyperthermia | 10.64 | 10.24 | 28 | 177797 | 10071 | 29764582 |
Hepatitis cholestatic | 10.64 | 10.24 | 19 | 177806 | 7853 | 29766800 |
Cholelithiasis | 10.63 | 10.24 | 174 | 177651 | 20051 | 29754602 |
Platelet count decreased | 10.62 | 10.24 | 749 | 177076 | 105380 | 29669273 |
Pulmonary valve stenosis | 10.60 | 10.24 | 12 | 177813 | 357 | 29774296 |
Chest expansion decreased | 10.60 | 10.24 | 8 | 177817 | 139 | 29774514 |
Respiratory depression | 10.58 | 10.24 | 34 | 177791 | 11469 | 29763184 |
Tumour lysis syndrome | 10.57 | 10.24 | 40 | 177785 | 12845 | 29761808 |
Anti-erythropoietin antibody positive | 10.55 | 10.24 | 19 | 177806 | 874 | 29773779 |
Squamous cell carcinoma | 10.53 | 10.24 | 100 | 177725 | 10150 | 29764503 |
Anaemia vitamin B12 deficiency | 10.51 | 10.24 | 11 | 177814 | 299 | 29774354 |
Body height decreased | 10.49 | 10.24 | 47 | 177778 | 3687 | 29770966 |
Spleen disorder | 10.47 | 10.24 | 20 | 177805 | 963 | 29773690 |
Acute graft versus host disease in skin | 10.41 | 10.24 | 7 | 177818 | 4509 | 29770144 |
Foetal hypokinesia | 10.39 | 10.24 | 12 | 177813 | 365 | 29774288 |
Central nervous system inflammation | 10.37 | 10.24 | 7 | 177818 | 101 | 29774552 |
Dairy intolerance | 10.34 | 10.24 | 3 | 177822 | 3 | 29774650 |
Anal atresia | 10.33 | 10.24 | 11 | 177814 | 305 | 29774348 |
Decreased vibratory sense | 10.31 | 10.24 | 12 | 177813 | 368 | 29774285 |
Gastrointestinal infection | 10.29 | 10.24 | 47 | 177778 | 3718 | 29770935 |
Suspected suicide | 10.27 | 10.24 | 3 | 177822 | 3158 | 29771495 |
Source | Code | Description |
---|---|---|
ATC | B03AE01 | BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS IRON PREPARATIONS Iron in other combinations |
ATC | B03BA01 | BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS VITAMIN B12 AND FOLIC ACID Vitamin B12 (cyanocobalamin and analogues) |
ATC | B03BA51 | BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS VITAMIN B12 AND FOLIC ACID Vitamin B12 (cyanocobalamin and analogues) |
FDA CS | M0022794 | Vitamin B 12 |
FDA EPC | N0000175951 | Vitamin B12 |
CHEBI has role | CHEBI:33229 | vitamins |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Pernicious anemia | indication | 84027009 | DOID:13381 |
Megaloblastic anemia due to folate deficiency | indication | 85649008 | DOID:14026 |
Vitamin deficiency | indication | 85670002 | |
Iron deficiency anemia | indication | 87522002 | |
Cobalamin deficiency | indication | 190634004 | |
Prevention of Vitamin B12 Deficiency | indication | ||
Vitamin Deficiency Prevention | indication | ||
Homocystinuria | off-label use | 11282001 | DOID:9263 |
Methylmalonic acidemia | off-label use | 42393006 | |
Homocystinemia | off-label use | 52311001 |
None
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Transcobalamin-1 | Secreted | WOMBAT-PK | |||||||
Protein amnionless | Unclassified | WOMBAT-PK | |||||||
Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial | Enzyme | WOMBAT-PK | |||||||
Methylmalonic aciduria type A protein, mitochondrial | Enzyme | WOMBAT-PK | |||||||
Transcobalamin-2 | Secreted | WOMBAT-PK | |||||||
Methionine synthase reductase | Enzyme | WOMBAT-PK | |||||||
Methionine synthase | Enzyme | WOMBAT-PK |
ID | Source |
---|---|
4021085 | VUID |
N0000148543 | NUI |
D00166 | KEGG_DRUG |
4017441 | VANDF |
4021085 | VANDF |
4021896 | VANDF |
C0042845 | UMLSCUI |
CHEBI:17439 | CHEBI |
CHEMBL2110563 | ChEMBL_ID |
DB00115 | DRUGBANK_ID |
CHEMBL2375172 | ChEMBL_ID |
54605677 | PUBCHEM_CID |
1369 | INN_ID |
P6YC3EG204 | UNII |
11248 | RXNORM |
213062 | MMSL |
257021 | MMSL |
4514 | MMSL |
5682 | MMSL |
6832 | MMSL |
6837 | MMSL |
8312 | MMSL |
d00413 | MMSL |
001043 | NDDF |
30010009 | SNOMEDCT_US |
419382002 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Cyanocobalamin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9619 | INJECTION | 1000 ug | INTRAMUSCULAR | ANDA | 21 sections |
Cyanocobalamin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9620 | INJECTION | 1000 ug | INTRAMUSCULAR | ANDA | 21 sections |
Cyanocobalamin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9621 | INJECTION | 1000 ug | INTRAMUSCULAR | ANDA | 21 sections |
Ferralet 90 | HUMAN PRESCRIPTION DRUG LABEL | 5 | 0178-0089 | TABLET, FILM COATED | 12 ug | ORAL | unapproved drug other | 17 sections |
NataFort | HUMAN PRESCRIPTION DRUG LABEL | 10 | 0178-0716 | TABLET | 12 ug | ORAL | Unapproved drug other | 12 sections |
CitraNatal Bloom | HUMAN PRESCRIPTION DRUG LABEL | 6 | 0178-0813 | TABLET, FILM COATED | 16.80 ug | ORAL | unapproved drug other | 15 sections |
Cyanocobalamin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0517-0031 | INJECTION, SOLUTION | 1000 ug | INTRAMUSCULAR | ANDA | 19 sections |
Cyanocobalamin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0517-0032 | INJECTION, SOLUTION | 1000 ug | INTRAMUSCULAR | ANDA | 19 sections |
Cyanocobalamin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0517-0130 | INJECTION, SOLUTION | 1000 ug | INTRAMUSCULAR | ANDA | 19 sections |
VitafolOne | HUMAN PRESCRIPTION DRUG LABEL | 16 | 0642-0070 | CAPSULE, GELATIN COATED | 0.01 mg | ORAL | unapproved drug other | 7 sections |
Vitafol Caplet | HUMAN PRESCRIPTION DRUG LABEL | 12 | 0642-0072 | CAPSULE | 5 ug | ORAL | UNULLPPROVED DRUG OTHER | 13 sections |
Vitafol OB Caplet | HUMAN PRESCRIPTION DRUG LABEL | 15 | 0642-0079 | TABLET | 12 ug | ORAL | Unapproved drug other | 14 sections |
Vitafol Plus | HUMAN PRESCRIPTION DRUG LABEL | 17 | 0642-0092 | CAPSULE, LIQUID FILLED | 12 ug | ORAL | UNULLPPROVED DRUG OTHER | 13 sections |
Vitafol Ultra | HUMAN PRESCRIPTION DRUG LABEL | 17 | 0642-0093 | CAPSULE, LIQUID FILLED | 12 ug | ORAL | UNULLPPROVED DRUG OTHER | 13 sections |
Vitafol Nano | HUMAN PRESCRIPTION DRUG LABEL | 7 | 0642-0094 | TABLET, COATED | 12 ug | ORAL | UNULLPPROVED DRUG OTHER | 14 sections |
Strovite Forte Caplet | HUMAN PRESCRIPTION DRUG LABEL | 19 | 0642-0204 | TABLET, COATED | 50 ug | ORAL | UNULLPPROVED DRUG OTHER | 15 sections |
Strovite One Caplets | HUMAN PRESCRIPTION DRUG LABEL | 20 | 0642-0207 | TABLET | 50 ug | ORAL | UNULLPPROVED DRUG OTHER | 14 sections |
Reaphirm Plant Source DHA | HUMAN PRESCRIPTION DRUG LABEL | 16 | 0642-3010 | CAPSULE, GELATIN COATED | 0.01 mg | ORAL | unapproved drug other | 7 sections |
Vitafol | HUMAN PRESCRIPTION DRUG LABEL | 4 | 0642-7468 | STRIP | 12 ug | ORAL | Unapproved drug other | 13 sections |
Vitafol Fe Plus | HUMAN PRESCRIPTION DRUG LABEL | 17 | 0642-7473 | CAPSULE, LIQUID FILLED | 25 ug | ORAL | UNULLPPROVED DRUG OTHER | 14 sections |
Marnatal F | HUMAN PRESCRIPTION DRUG LABEL | 13 | 0682-1570 | CAPSULE | 12 ug | ORAL | UNULLPPROVED DRUG OTHER | 4 sections |
BACMIN | HUMAN PRESCRIPTION DRUG LABEL | 19 | 0682-3001 | TABLET, COATED | 50 ug | ORAL | UNULLPPROVED DRUG OTHER | 10 sections |
O-Cal Prenatal Vitamin | HUMAN PRESCRIPTION DRUG LABEL | 16 | 0813-0202 | TABLET | 12 ug | ORAL | UNULLPPROVED DRUG OTHER | 6 sections |
PRENULLTAL PLUS | HUMAN PRESCRIPTION DRUG LABEL | 15 | 10544-549 | TABLET, FILM COATED | 12 ug | ORAL | unapproved drug other | 8 sections |
PRENULLTAL PLUS IRON | HUMAN PRESCRIPTION DRUG LABEL | 15 | 10544-609 | TABLET, FILM COATED | 12 ug | ORAL | UNULLPPROVED DRUG OTHER | 7 sections |
Se-Natal 19 | HUMAN PRESCRIPTION DRUG LABEL | 15 | 13925-116 | TABLET | 12 ug | ORAL | unapproved drug other | 15 sections |
Se-Natal 19 Chewable | HUMAN PRESCRIPTION DRUG LABEL | 14 | 13925-117 | TABLET, CHEWABLE | 12 ug | ORAL | unapproved drug other | 16 sections |
Se-Tan PLUS | HUMAN PRESCRIPTION DRUG LABEL | 13 | 13925-118 | CAPSULE, GELATIN COATED | 15 ug | ORAL | unapproved drug other | 19 sections |
PRENULLTAL PLUS | HUMAN PRESCRIPTION DRUG LABEL | 15 | 15338-522 | TABLET, FILM COATED | 12 ug | ORAL | unapproved drug other | 8 sections |
Quflora Pediatric Drops | HUMAN PRESCRIPTION DRUG LABEL | 13 | 15370-100 | LIQUID | 2 ug | ORAL | UNULLPPROVED DRUG OTHER | 11 sections |