iron 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4277	7439-89-6

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: iron elemental iron (as carbonyl iron)	A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN. Molecular weight: 55.85 Formula: Fe CLOGP: -1.32 LIPINSKI: None HAC: 0 HDO: 0 TPSA: ALOGS: ROTB: 0

Molecule

Description

Molfile Inchi Smiles

Synonyms:

iron
elemental iron (as carbonyl iron)

A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.

Molecular weight: 55.85
Formula: Fe
CLOGP: -1.32
LIPINSKI: None
HAC: 0
HDO: 0
TPSA:
ALOGS:
ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hand deformity	166.36	10	7	78219	159450	63251346
Glossodynia	155.09	10	19	78207	178857	63231939
Haemoglobin decreased	137.51	10	443	77783	145042	63265754
Blood iron decreased	128.74	10	122	78104	14599	63396197
Pericarditis	124.41	10	10	78216	131569	63279227
Systemic lupus erythematosus	104.58	10	64	78162	208854	63201942
Helicobacter infection	96.99	10	4	78222	92781	63318015
Anaemia	96.93	10	656	77570	292774	63118022
Contraindicated product administered	95.32	10	77	78149	217571	63193225
Premature labour	91.45	10	94	78132	12410	63398386

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Colitis ulcerative	158.46	11.77	125	30698	16395	34909713
Blood iron decreased	100.30	11.77	61	30762	5252	34920856
Fatigue	86.48	11.77	590	30233	370063	34556045
Haematochezia	77.99	11.77	144	30679	46390	34879718
Diarrhoea	72.89	11.77	589	30234	389323	34536785
Nipple swelling	69.35	11.77	21	30802	306	34925802
Drug abuse	62.81	11.77	7	30816	99089	34827019
Frequent bowel movements	51.62	11.77	60	30763	12727	34913381
Nipple pain	51.04	11.77	22	30801	915	34925193
Haemoglobin decreased	47.80	11.77	222	30601	120550	34805558

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Colitis ulcerative	210.79	10.14	222	85713	34520	79623933
Blood iron decreased	183.55	10.14	144	85791	15290	79643163
Haematochezia	127.76	10.14	288	85647	87357	79571096
Haemoglobin decreased	126.40	10.14	524	85411	221595	79436858
Drug abuse	123.59	10.14	15	85920	162676	79495777
Frequent bowel movements	106.76	10.14	145	85790	29394	79629059
Abdominal pain	101.59	10.14	743	85192	388826	79269627
Off label use	98.13	10.14	1444	84491	905771	78752682
Toxicity to various agents	91.40	10.14	199	85736	421341	79237112
Inappropriate schedule of product administration	90.37	10.14	333	85602	133295	79525158

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FDA Adverse Event Reporting System (Pediatric)

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Pharmacologic Action:

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Source	Code	Description
ATC	A11AA01	ALIMENTARY TRACT AND METABOLISM VITAMINS MULTIVITAMINS, COMBINATIONS Multivitamins with minerals
ATC	B03AE01	BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS IRON PREPARATIONS Iron in other combinations
ATC	B03AE02	BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS IRON PREPARATIONS Iron in other combinations
ATC	B03AE03	BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS IRON PREPARATIONS Iron in other combinations
ATC	B03AE04	BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS IRON PREPARATIONS Iron in other combinations
CHEBI has role	CHEBI:27027	trace elements
CHEBI has role	CHEBI:76971	Escherichia coli metabolites
MeSH PA	D018977	Micronutrients
MeSH PA	D014131	Trace Elements

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Anemia of prematurity	indication	47100003	DOID:11243
Megaloblastic anemia due to folate deficiency	indication	85649008	DOID:14026
Iron deficiency anemia	indication	87522002
Magnetic resonance imaging of liver	indication	241622002
Peptic ulcer	contraindication	13200003	DOID:750
Gastroenteritis	contraindication	25374005	DOID:2326
Hemosiderosis	contraindication	39011001	DOID:12119
Hemolytic anemia	contraindication	61261009	DOID:583
Ulcerative colitis	contraindication	64766004	DOID:8577
Diverticular disease	contraindication	397881000

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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ID	Source
000828	NDDF
007431	NDDF
20159	MMSL
23925	PUBCHEM_CID
262150	RXNORM
30729008	SNOMEDCT_US
30873	MMSL
30874	MMSL
32954005	SNOMEDCT_US
34448	MMSL

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
CitraNatal 90 DHA	HUMAN PRESCRIPTION DRUG LABEL	16	0178-0821	TABLET	85 mg	ORAL	unapproved drug other	11 sections
CitraNatal 90 DHA	HUMAN PRESCRIPTION DRUG LABEL	16	0178-0821	TABLET	85 mg	ORAL	unapproved drug other	11 sections
CitraNatal 90 DHA	HUMAN OTC DRUG LABEL	14	0178-0829	TABLET	90 mg	ORAL	Unapproved drug other	11 sections
CitraNatal DHA	HUMAN OTC DRUG LABEL	14	0178-0898	TABLET	27 mg	ORAL	Unapproved drug other	11 sections
Citranatal Harmony 2.1	HUMAN PRESCRIPTION DRUG LABEL	2	0178-0797	CAPSULE, GELATIN COATED	29 mg	ORAL	unapproved drug other	10 sections
CitraNatal Harmony 3.0	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0796	CAPSULE, GELATIN COATED	27 mg	ORAL	unapproved drug other	10 sections
CitraNatal Harmony 3.0	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0796	CAPSULE, GELATIN COATED	27 mg	ORAL	unapproved drug other	10 sections
CitraNatal Medley	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0896	CAPSULE, GELATIN COATED	27 mg	ORAL	unapproved drug other	10 sections
CitraNatal Medley	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0896	CAPSULE, GELATIN COATED	27 mg	ORAL	unapproved drug other	10 sections
CitraNatal Rx	HUMAN PRESCRIPTION DRUG LABEL	13	0178-0858	TABLET	27 mg	ORAL	Unapproved drug other	12 sections

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