iron 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4277 7439-89-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • iron
  • elemental iron (as carbonyl iron)
A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
  • Molecular weight: 55.85
  • Formula: Fe
  • CLOGP: -1.32
  • LIPINSKI: None
  • HAC: 0
  • HDO: 0
  • TPSA:
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hand deformity 166.36 10 7 78219 159450 63251346
Glossodynia 155.09 10 19 78207 178857 63231939
Haemoglobin decreased 137.51 10 443 77783 145042 63265754
Blood iron decreased 128.74 10 122 78104 14599 63396197
Pericarditis 124.41 10 10 78216 131569 63279227
Systemic lupus erythematosus 104.58 10 64 78162 208854 63201942
Helicobacter infection 96.99 10 4 78222 92781 63318015
Anaemia 96.93 10 656 77570 292774 63118022
Contraindicated product administered 95.32 10 77 78149 217571 63193225
Premature labour 91.45 10 94 78132 12410 63398386
Colitis ulcerative 90.93 10 135 78091 25956 63384840
Drug intolerance 78.67 10 164 78062 308497 63102299
Heavy menstrual bleeding 78.42 10 103 78123 17670 63393126
Exposure during pregnancy 76.86 10 387 77839 155160 63255636
Synovitis 72.45 10 74 78152 186844 63223952
Haematochezia 70.79 10 184 78042 53360 63357436
Product dose omission issue 70.36 10 512 77714 233801 63176995
Discomfort 67.47 10 64 78162 167310 63243486
Premature delivery 65.93 10 127 78099 30154 63380642
Wound 65.14 10 63 78163 163200 63247596
Drug ineffective 62.93 10 909 77317 1043856 62366940
Frequent bowel movements 62.14 10 106 78120 22916 63387880
Weight decreased 60.57 10 563 77663 276235 63134561
Folliculitis 59.62 10 8 78218 70309 63340487
Toxicity to various agents 59.14 10 136 78090 247114 63163682
Drug abuse 55.35 10 11 78215 72507 63338289
Abdominal pain 54.55 10 577 77649 292879 63117917
Muscle injury 54.08 10 8 78218 65337 63345459
Swelling 51.31 10 171 78055 275207 63135589
Intentional overdose 47.52 10 16 78210 74136 63336660
Sleep disorder due to general medical condition, insomnia type 46.59 10 5 78221 52212 63358584
Hair follicle tumour benign 45.95 10 18 78208 413 63410383
Alopecia 45.25 10 238 77988 337298 63073498
Therapeutic product effect decreased 44.79 10 108 78118 193079 63217717
Irritable bowel syndrome 44.43 10 23 78203 82389 63328407
Treatment failure 44.02 10 114 78112 198929 63211867
Arthropathy 43.58 10 146 78080 234646 63176150
Blister 43.18 10 58 78168 129756 63281040
Mineral supplementation 42.45 10 20 78206 729 63410067
Transfusion 42.31 10 71 78155 15146 63395650
Vaginal haemorrhage 42.17 10 100 78126 27387 63383409
Hypersensitivity 41.71 10 202 78024 292483 63118313
Drug interaction 40.83 10 145 78081 228986 63181810
Allergy to metals 39.74 10 19 78207 716 63410080
Choreoathetosis 39.10 10 17 78209 512 63410284
Blood cholesterol increased 39.01 10 35 78191 93997 63316799
Therapeutic reaction time decreased 38.22 10 28 78198 2342 63408454
Ill-defined disorder 38.22 10 27 78199 81728 63329068
Clostridium difficile infection 37.68 10 101 78125 29821 63380975
Overdose 37.68 10 52 78174 115026 63295770
Liver injury 37.17 10 14 78212 60506 63350290
Off label use 36.88 10 1089 77137 673373 62737423
Hepatic enzyme increased 36.73 10 127 78099 202201 63208595
Abdominal discomfort 36.73 10 238 77988 320647 63090149
Inappropriate schedule of product administration 36.38 10 236 77990 103729 63307067
Device expulsion 36.31 10 110 78116 34812 63375984
Uterine leiomyoma 35.56 10 50 78176 9148 63401648
Defaecation urgency 35.36 10 34 78192 4141 63406655
Joint swelling 35.03 10 248 77978 327418 63083378
Full blood count abnormal 34.96 10 102 78124 31615 63379181
Poor venous access 34.65 10 64 78162 14721 63396075
Diarrhoea 33.57 10 1134 77092 714232 62696564
Chronic disease 33.17 10 11 78215 153 63410643
C-reactive protein abnormal 33.13 10 8 78218 46088 63364708
Neutropenia 32.34 10 109 78117 174896 63235900
Caesarean section 31.78 10 67 78159 16965 63393831
Crohn's disease 30.73 10 34 78192 4879 63405917
Gastrointestinal haemorrhage 30.71 10 188 78038 80988 63329808
Blood pressure fluctuation 30.11 10 125 78101 46192 63364604
Athetosis 29.68 10 8 78218 51 63410745
Device dislocation 29.62 10 84 78142 25621 63385175
Heart rate increased 29.43 10 208 78018 94030 63316766
Fluid retention 29.08 10 148 78078 59538 63351258
Complications of bone marrow transplant 28 10 13 78213 458 63410338
Confusional state 27.71 10 174 78052 236206 63174590
Faeces discoloured 26.95 10 66 78160 18443 63392353
Stomatitis 26.59 10 85 78141 138640 63272156
Iron deficiency 26.04 10 38 78188 7192 63403604
Mobility decreased 25.56 10 71 78155 121088 63289708
Hepatosplenic T-cell lymphoma 24.95 10 13 78213 590 63410206
Anal fissure 24.83 10 29 78197 4414 63406382
Normal newborn 24.64 10 40 78186 8301 63402495
Device placement issue 24.29 10 17 78209 1323 63409473
Illness 24.15 10 122 78104 48937 63361859
Blood albumin decreased 24.05 10 55 78171 14711 63396085
Myringotomy 24.01 10 6 78220 27 63410769
Cardiac arrest 23.67 10 49 78177 92496 63318300
General physical health deterioration 23.21 10 149 78077 201253 63209543
Febrile neutropenia 23.11 10 72 78154 118377 63292419
Nasal congestion 22.93 10 149 78077 65511 63345285
Fibromyalgia 22.83 10 40 78186 80380 63330416
Headache 22.53 10 974 77252 632267 62778529
Joint space narrowing 22.34 10 12 78214 580 63410216
Drug reaction with eosinophilia and systemic symptoms 22.21 10 7 78219 33829 63376967
Intestinal obstruction 22.17 10 86 78140 30813 63379983
Gastrointestinal tract mucosal pigmentation 22.15 10 12 78214 590 63410206
Complication of device insertion 21.97 10 36 78190 7528 63403268
Small intestine ulcer 21.68 10 10 78216 347 63410449
Iodine allergy 21.46 10 13 78213 791 63410005
Vitamin D decreased 21.13 10 42 78184 10200 63400596
Maternal exposure during breast feeding 20.95 10 26 78200 4215 63406581
Iron deficiency anaemia 20.85 10 63 78163 19906 63390890
Dysmenorrhoea 20.66 10 25 78201 3948 63406848
Infusion related reaction 20.66 10 198 78028 245323 63165473
Hip arthroplasty 20.65 10 17 78209 47629 63363167
Hyponatraemia 20.45 10 70 78156 111830 63298966
Acute kidney injury 19.87 10 218 78008 263197 63147599
Pregnancy 19.84 10 94 78132 36742 63374054
Rash 19.80 10 533 77693 560338 62850458
Stress 19.67 10 146 78080 67021 63343775
Flushing 19.11 10 158 78068 74929 63335867
Incorrect dose administered 19.09 10 133 78093 59835 63350961
Preterm premature rupture of membranes 19.08 10 15 78211 1394 63409402
Blood growth hormone increased 19.07 10 10 78216 460 63410336
Arthritis infective 19.05 10 31 78195 6447 63404349
Suicide attempt 18.49 10 29 78197 60889 63349907
Depressed level of consciousness 18.42 10 30 78196 62048 63348748
Eosinophilia 18.34 10 3 78223 22753 63388043
Granuloma skin 17.89 10 35 78191 8402 63402394
Chills 17.87 10 216 78010 113162 63297634
Empty sella syndrome 17.79 10 5 78221 38 63410758
Prescribed overdose 17.72 10 10 78216 34143 63376653
Gastric bypass 17.71 10 16 78210 1801 63408995
Psoriatic arthropathy 17.59 10 56 78170 91464 63319332
Splenomegaly 17.56 10 41 78185 11116 63399680
Red blood cell count decreased 17.22 10 97 78129 40548 63370248
Abnormal faeces 17.18 10 27 78199 5453 63405343
Hypervolaemia 17.16 10 75 78151 28338 63382458
Delayed haemolytic transfusion reaction 17.10 10 3 78223 0 63410796
Drug level decreased 16.97 10 33 78193 7886 63402910
Impaired healing 16.87 10 67 78159 102475 63308321
Drug level below therapeutic 16.70 10 25 78201 4841 63405955
Rheumatoid factor positive 16.68 10 51 78175 84355 63326441
Oropharyngeal pain 16.67 10 184 78042 94303 63316493
Fatigue 16.65 10 1289 76937 886739 62524057
Embedded device 16.64 10 21 78205 3462 63407334
Abdominal abscess 16.61 10 24 78202 4502 63406294
Intestinal resection 16.60 10 19 78207 2829 63407967
Blood parathyroid hormone decreased 16.53 10 37 78189 9754 63401042
Coma 16.52 10 34 78192 64330 63346466
Muscle spasms 16.40 10 277 77949 155873 63254923
Natural killer cell count 16.38 10 4 78222 16 63410780
Amegakaryocytic thrombocytopenia 16.38 10 4 78222 16 63410780
Antineutrophil cytoplasmic antibody positive 16.34 10 10 78216 620 63410176
Rhabdomyolysis 16.34 10 18 78208 43933 63366863
Vascular device infection 16.32 10 31 78195 7281 63403515
Mucous stools 16.28 10 23 78203 4225 63406571
Uterine perforation 16.14 10 30 78196 6933 63403863
Full blood count decreased 15.95 10 69 78157 25955 63384841
Haemoglobin abnormal 15.85 10 25 78201 5063 63405733
Intermenstrual bleeding 15.75 10 32 78194 7894 63402902
Rhinorrhoea 15.63 10 136 78090 65441 63345355
Vascular stenosis 15.58 10 8 78218 352 63410444
Malabsorption 15.54 10 22 78204 4050 63406746
Premature separation of placenta 15.47 10 15 78211 1846 63408950
Sinus pain 15.41 10 20 78206 3390 63407406
Myelosuppression 15.38 10 5 78221 23698 63387098
Macrophages increased 15.19 10 4 78222 23 63410773
Urinary tract infection 15.09 10 430 77796 264254 63146542
Chronic spontaneous urticaria 14.99 10 12 78214 1145 63409651
Faecal calprotectin increased 14.81 10 19 78207 3184 63407612
Haematocrit decreased 14.80 10 91 78135 39249 63371547
Small intestinal obstruction 14.79 10 53 78173 18284 63392512
Hospitalisation 14.70 10 165 78061 84916 63325880
Foreign body in reproductive tract 14.61 10 10 78216 751 63410045
Dyschezia 14.56 10 16 78210 2278 63408518
Multiple organ dysfunction syndrome 14.55 10 30 78196 56722 63354074
Injection site alopecia 14.52 10 4 78222 28 63410768
Small intestinal stenosis 14.50 10 9 78217 572 63410224
Polymenorrhoea 14.42 10 12 78214 1209 63409587
Completed suicide 14.23 10 113 78113 145560 63265236
Toxoplasmosis 14.04 10 13 78213 1510 63409286
Serotonin syndrome 14.03 10 9 78217 28673 63382123
Grip strength decreased 13.95 10 5 78221 22282 63388514
Intercepted medication error 13.94 10 9 78217 613 63410183
Appetite disorder 13.89 10 29 78197 7292 63403504
Pre-eclampsia 13.76 10 33 78193 9100 63401696
Haemorrhage 13.75 10 125 78101 60897 63349899
Acute lung injury 13.70 10 13 78213 1558 63409238
Leukopenia 13.69 10 49 78177 77241 63333555
Nephrogenic systemic fibrosis 13.66 10 22 78204 4534 63406262
Joint range of motion decreased 13.53 10 12 78214 32416 63378380
Eosinophilic pneumonia chronic 13.46 10 6 78220 192 63410604
Dizziness 13.44 10 653 77573 429272 62981524
Blood pressure increased 13.38 10 277 77949 161785 63249011
Vaginal infection 13.36 10 29 78197 7489 63403307
Uterine atony 13.29 10 6 78220 198 63410598
Platelet count increased 13.28 10 50 78176 17661 63393135
Sedation 13.24 10 17 78209 38792 63372004
Weight fluctuation 13.23 10 34 78192 9785 63401011
Skin warm 13.20 10 24 78202 5452 63405344
Gastrointestinal disorder 13.19 10 101 78125 131138 63279658
Maternal exposure before pregnancy 13.14 10 29 78197 7574 63403222
Mean cell haemoglobin concentration decreased 13.03 10 19 78207 3593 63407203
Fistula 13 10 35 78191 10358 63400438
Hepatic function abnormal 12.96 10 16 78210 37126 63373670
Asthenia 12.92 10 587 77639 383017 63027779
Body temperature fluctuation 12.91 10 15 78211 2270 63408526
Postpartum haemorrhage 12.90 10 14 78212 1967 63408829
Bone marrow reticulin fibrosis 12.83 10 6 78220 215 63410581
COVID-19 12.75 10 203 78023 112900 63297896
Palindromic rheumatism 12.73 10 6 78220 219 63410577
Rash pruritic 12.72 10 121 78105 59678 63351118
Septic shock 12.64 10 41 78185 66588 63344208
Cytomegalovirus infection 12.61 10 5 78221 20947 63389849
Respiratory arrest 12.54 10 13 78213 32632 63378164
Hyperparathyroidism secondary 12.52 10 12 78214 1455 63409341
Molluscum contagiosum 12.50 10 6 78220 228 63410568
Stress at work 12.50 10 11 78215 1196 63409600
Anal incontinence 12.49 10 41 78185 13535 63397261
Dermatitis atopic 12.42 10 33 78193 9691 63401105
Bronchospasm 12.41 10 3 78223 17277 63393519
Rectal haemorrhage 12.38 10 103 78123 48927 63361869
Uterine contractions during pregnancy 12.30 10 8 78218 552 63410244
Acute myeloid leukaemia 12.27 10 3 78223 17144 63393652
Flatulence 12.27 10 79 78147 34623 63376173
Glomerulonephritis rapidly progressive 12.22 10 10 78216 985 63409811
Hot flush 12.14 10 106 78120 51053 63359743
Rash macular 12.13 10 59 78167 23305 63387491
Insomnia 12.07 10 349 77877 214903 63195893
Sinus disorder 12.04 10 61 78165 24492 63386304
Pneumocystis jirovecii pneumonia 12.03 10 3 78223 16911 63393885
Drug specific antibody present 12.01 10 20 78206 4239 63406557
Shock 11.99 10 7 78219 23456 63387340
Panniculitis 11.96 10 36 78190 11349 63399447
Agitation 11.88 10 36 78190 59721 63351075
Complication of device removal 11.72 10 22 78204 5120 63405676
Oedema peripheral 11.67 10 311 77915 189200 63221596
Cough 11.67 10 456 77770 292287 63118509
Device breakage 11.66 10 36 78190 11506 63399290
Wound infection bacterial 11.63 10 8 78218 606 63410190
Condition aggravated 11.56 10 606 77620 401611 63009185
Haemorrhoids 11.55 10 56 78170 22094 63388702
Sulphaemoglobinaemia 11.43 10 3 78223 17 63410779
Uterine haemorrhage 11.43 10 19 78207 4022 63406774
Creatinine renal clearance decreased 11.39 10 3 78223 16305 63394491
Pulmonary cavitation 11.37 10 9 78217 845 63409951
Crystal urine present 11.31 10 12 78214 1642 63409154
Myelofibrosis 11.26 10 11 78215 1366 63409430
Antineutrophil cytoplasmic antibody increased 11.25 10 5 78221 159 63410637
Renal transplant 11.24 10 11 78215 1369 63409427
Gastrointestinal bacterial overgrowth 11.11 10 9 78217 873 63409923
Delivery 11.09 10 11 78215 1392 63409404
Thyroid adenoma 11.05 10 5 78221 166 63410630
Pulmonary arterial hypertension 11.01 10 56 78170 22521 63388275
Cholestasis 11.00 10 12 78214 29422 63381374
Overlap syndrome 10.99 10 9 78217 887 63409909
Type 2 diabetes mellitus 10.97 10 41 78185 63827 63346969
Premature rupture of membranes 10.94 10 21 78205 4972 63405824
Bursitis 10.90 10 18 78208 37023 63373773
Breath sounds abnormal 10.88 10 34 78192 10939 63399857
Diarrhoea haemorrhagic 10.86 10 30 78196 9012 63401784
Hypokalaemia 10.85 10 79 78147 103725 63307071
Otorrhoea 10.85 10 11 78215 1428 63409368
Twin pregnancy 10.79 10 10 78216 1163 63409633
Blood creatine phosphokinase increased 10.73 10 13 78213 30417 63380379
Cardio-respiratory arrest 10.62 10 38 78188 59921 63350875
Ileostomy 10.58 10 11 78215 1471 63409325
Lower respiratory tract infection 10.57 10 108 78118 132199 63278597
Purulent discharge 10.56 10 20 78206 4686 63406110
Sterile pyuria 10.54 10 3 78223 24 63410772
Knee arthroplasty 10.53 10 33 78193 54173 63356623
Drug hypersensitivity 10.48 10 297 77929 310390 63100406
Gastrointestinal candidiasis 10.44 10 5 78221 189 63410607
Hepatocellular injury 10.41 10 11 78215 27370 63383426
Sprue-like enteropathy 10.26 10 8 78218 735 63410061
Anaemia of pregnancy 10.24 10 4 78222 91 63410705
Liver disorder 10.21 10 33 78193 53654 63357142
Cataplexy 10.21 10 10 78216 1246 63409550
Drug resistance 10.16 10 8 78218 22925 63387871
Amniotic cavity infection 10.16 10 10 78216 1253 63409543
Viral infection 10.14 10 77 78149 35586 63375210
Peritonitis bacterial 10.05 10 20 78206 4859 63405937
Hypercholesterolaemia 10.03 10 7 78219 21327 63389469

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Colitis ulcerative 158.46 11.77 125 30698 16395 34909713
Blood iron decreased 100.30 11.77 61 30762 5252 34920856
Fatigue 86.48 11.77 590 30233 370063 34556045
Haematochezia 77.99 11.77 144 30679 46390 34879718
Diarrhoea 72.89 11.77 589 30234 389323 34536785
Nipple swelling 69.35 11.77 21 30802 306 34925802
Drug abuse 62.81 11.77 7 30816 99089 34827019
Frequent bowel movements 51.62 11.77 60 30763 12727 34913381
Nipple pain 51.04 11.77 22 30801 915 34925193
Haemoglobin decreased 47.80 11.77 222 30601 120550 34805558
Abdominal pain 46.30 11.77 274 30549 163344 34762764
Weight decreased 42.27 11.77 283 30540 176018 34750090
Febrile neutropenia 41.24 11.77 36 30787 136813 34789295
Inappropriate schedule of product administration 40.53 11.77 134 30689 62162 34863946
Device interaction 39.55 11.77 16 30807 566 34925542
Full blood count decreased 38.16 11.77 62 30761 18026 34908082
Toxicity to various agents 35.88 11.77 77 30746 200285 34725823
Asthenia 35.56 11.77 351 30472 244900 34681208
Faecal calprotectin increased 35.14 11.77 24 30799 2520 34923588
Large intestine polyp 33.40 11.77 38 30785 7876 34918232
Off label use 33.15 11.77 536 30287 418988 34507120
Exposure during pregnancy 32.89 11.77 40 30783 8894 34917214
Clostridium difficile infection 32.29 11.77 59 30764 18839 34907269
Crohn's disease 30.77 11.77 24 30799 3093 34923015
Faeces discoloured 30.04 11.77 50 30773 14828 34911280
Mucous stools 29.97 11.77 19 30804 1759 34924349
Polyneuropathy in malignant disease 28.57 11.77 10 30813 235 34925873
Interstitial lung disease 28.39 11.77 11 30812 65271 34860837
Gastrointestinal tract mucosal pigmentation 28.32 11.77 12 30811 478 34925630
Nephrogenic systemic fibrosis 27.47 11.77 25 30798 3980 34922128
Weight increased 27.04 11.77 157 30666 92876 34833232
Blood pressure fluctuation 26.94 11.77 65 30758 25184 34900924
Gastrointestinal haemorrhage 26.82 11.77 151 30672 88326 34837782
Polyp 26.12 11.77 24 30799 3868 34922240
Maternal exposure before pregnancy 25.73 11.77 13 30810 778 34925330
Drug interaction 25.23 11.77 108 30715 225838 34700270
Acute kidney injury 25.00 11.77 162 30661 304826 34621282
Constipation 24.88 11.77 206 30617 136776 34789332
Anaemia 24.68 11.77 314 30509 233021 34693087
Mineral supplementation 23.71 11.77 7 30816 93 34926015
Product dose omission issue 23.35 11.77 183 30640 119528 34806580
Condition aggravated 22.20 11.77 263 30560 191933 34734175
Flatulence 20.95 11.77 53 30770 21145 34904963
Muscle spasms 20.14 11.77 124 30699 74877 34851231
Intentional product use issue 20.08 11.77 105 30718 59711 34866397
Iron deficiency anaemia 19.90 11.77 34 30789 10295 34915813
Blood pressure increased 19.62 11.77 139 30684 87963 34838145
Intentional overdose 19.59 11.77 7 30816 43667 34882441
Rhabdomyolysis 19.25 11.77 19 30804 68144 34857964
Normochromic normocytic anaemia 18.80 11.77 21 30802 4266 34921842
Gastrointestinal inflammation 18.57 11.77 19 30804 3492 34922616
Intestinal resection 18.43 11.77 14 30809 1735 34924373
Completed suicide 18.15 11.77 37 30786 98131 34827977
Suicide attempt 18.01 11.77 6 30817 39110 34886998
Hospitalisation 17.82 11.77 98 30725 56804 34869304
Arthralgia 17.60 11.77 228 30595 169813 34756295
Vanishing bile duct syndrome 17.46 11.77 11 30812 1007 34925101
Abdominal discomfort 17.39 11.77 101 30722 59734 34866374
Agitated depression 17.29 11.77 7 30816 248 34925860
Thrombocytopenia 17.23 11.77 75 30748 156172 34769936
Aplasia pure red cell 17.18 11.77 24 30799 6108 34920000
Poor venous access 17.15 11.77 22 30801 5161 34920947
Haemorrhage 17.12 11.77 90 30733 51280 34874828
Heart rate decreased 16.94 11.77 64 30759 31681 34894427
Aspartate aminotransferase increased 16.83 11.77 21 30802 67762 34858346
Malaise 16.72 11.77 243 30580 185582 34740526
Thrombosis 16.54 11.77 88 30735 50370 34875738
Anal ulcer 16.28 11.77 10 30813 876 34925232
Gastroduodenal haemorrhage 15.92 11.77 6 30817 175 34925933
Intestinal obstruction 15.65 11.77 50 30773 22772 34903336
Therapeutic reaction time decreased 15.31 11.77 11 30812 1252 34924856
Low birth weight baby 15.20 11.77 26 30797 7879 34918229
Diet noncompliance 15.17 11.77 6 30817 200 34925908
Therapeutic response shortened 15.10 11.77 25 30798 7379 34918729
Premature baby 14.37 11.77 44 30779 19589 34906519
Faecal calprotectin abnormal 14.23 11.77 6 30817 236 34925872
Nasopharyngitis 14.20 11.77 108 30715 69860 34856248
Drug-induced liver injury 14.03 11.77 4 30819 28828 34897280
Abdominal distension 14.03 11.77 94 30729 58398 34867710
Agitation 14.02 11.77 18 30805 57381 34868727
Skin induration 13.92 11.77 13 30810 2138 34923970
Autoscopy 13.89 11.77 6 30817 251 34925857
Supraventricular tachycardia 13.37 11.77 30 30793 11087 34915021
Heart rate increased 13.31 11.77 78 30745 46265 34879843
Aphthous ulcer 13.18 11.77 19 30804 4976 34921132
Hip fracture 13.04 11.77 31 30792 11894 34914214
Spondylitis 12.96 11.77 10 30813 1268 34924840
Hernia 12.82 11.77 27 30796 9556 34916552
Drug level decreased 12.78 11.77 24 30799 7822 34918286
Anaemia neonatal 12.68 11.77 6 30817 311 34925797
Intestinal mucosal hypertrophy 12.53 11.77 4 30819 70 34926038
Product use issue 12.51 11.77 97 30726 63119 34862989
Fistula 12.51 11.77 22 30801 6818 34919290
Anal fissure 12.33 11.77 17 30806 4273 34921835
Inflammatory bowel disease 12.28 11.77 14 30809 2906 34923202
Meconium abnormal 12.13 11.77 4 30819 78 34926030
Gait inability 12.04 11.77 43 30780 20715 34905393
Cerebral haemorrhage 12.03 11.77 8 30815 34929 34891179
Maternal exposure during pregnancy 11.96 11.77 18 30805 4900 34921208
Intestinal stenosis 11.87 11.77 12 30811 2174 34923934
Gastroenteritis viral 11.86 11.77 22 30801 7102 34919006
Allodynia 11.86 11.77 8 30815 823 34925285
Faeces soft 11.78 11.77 15 30808 3493 34922615

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Colitis ulcerative 210.79 10.14 222 85713 34520 79623933
Blood iron decreased 183.55 10.14 144 85791 15290 79643163
Haematochezia 127.76 10.14 288 85647 87357 79571096
Haemoglobin decreased 126.40 10.14 524 85411 221595 79436858
Drug abuse 123.59 10.14 15 85920 162676 79495777
Frequent bowel movements 106.76 10.14 145 85790 29394 79629059
Abdominal pain 101.59 10.14 743 85192 388826 79269627
Off label use 98.13 10.14 1444 84491 905771 78752682
Toxicity to various agents 91.40 10.14 199 85736 421341 79237112
Inappropriate schedule of product administration 90.37 10.14 333 85602 133295 79525158
Premature delivery 89.10 10.14 118 85817 23349 79635104
Hand deformity 82.94 10.14 8 85927 103911 79554542
Weight decreased 80.61 10.14 656 85279 354542 79303911
Exposure during pregnancy 80.48 10.14 266 85669 100866 79557587
Fatigue 80.30 10.14 1426 84509 928301 78730152
Heavy menstrual bleeding 75.29 10.14 84 85851 13927 79644526
Pericarditis 73.55 10.14 12 85923 104224 79554229
Anaemia 69.50 10.14 759 85176 444256 79214197
Drug interaction 68.73 10.14 224 85711 414959 79243494
Clostridium difficile infection 67.53 10.14 145 85790 42540 79615913
Product dose omission issue 66.66 10.14 476 85459 247061 79411392
Nipple swelling 65.58 10.14 21 85914 300 79658153
Neutropenia 61.33 10.14 137 85798 287573 79370880
Febrile neutropenia 60.65 10.14 97 85838 230902 79427551
Acute kidney injury 59.47 10.14 323 85612 519081 79139372
Diarrhoea 59.23 10.14 1301 84634 879188 78779265
Duodenal ulcer perforation 58.87 10.14 3 85932 66208 79592245
Mineral supplementation 58.87 10.14 25 85910 815 79657638
Intentional overdose 57.68 10.14 21 85914 105939 79552514
Blood pressure fluctuation 55.56 10.14 179 85756 66966 79591487
Glossodynia 55.37 10.14 21 85914 103316 79555137
Poor venous access 55.11 10.14 82 85853 18067 79640386
Condition aggravated 54.82 10.14 800 85135 500324 79158129
Faecal calprotectin increased 53.90 10.14 46 85889 5495 79652958
Therapeutic reaction time decreased 53.55 10.14 38 85897 3463 79654990
Faeces discoloured 52.01 10.14 104 85831 29023 79629430
Device expulsion 50.63 10.14 96 85839 25765 79632688
Gastrointestinal tract mucosal pigmentation 50.44 10.14 24 85911 1026 79657427
Overdose 49.63 10.14 76 85859 184130 79474323
Helicobacter infection 49.23 10.14 8 85927 69696 79588757
Contraindicated product administered 47.43 10.14 60 85875 157478 79500975
Nipple pain 47.05 10.14 22 85913 904 79657549
Synovitis 46.87 10.14 56 85879 150678 79507775
Hair follicle tumour benign 46.78 10.14 18 85917 452 79658001
Mucous stools 46.47 10.14 41 85894 5121 79653332
Premature labour 46.28 10.14 51 85884 8339 79650114
Intentional product use issue 45.35 10.14 300 85635 151812 79506641
Gastrointestinal haemorrhage 43.83 10.14 291 85644 147428 79511025
Hepatic function abnormal 42.39 10.14 13 85922 73094 79585359
Defaecation urgency 42.23 10.14 41 85894 5783 79652670
Anal fissure 39.37 10.14 45 85890 7658 79650795
Drug intolerance 38.01 10.14 151 85784 263968 79394485
Rhabdomyolysis 36.90 10.14 34 85901 103097 79555356
Heart rate increased 36.52 10.14 239 85696 120485 79537968
Device dislocation 36.33 10.14 84 85851 25886 79632567
Caesarean section 35.74 10.14 55 85880 12480 79645973
Folliculitis 35.62 10.14 8 85927 55372 79603081
Muscle injury 35.60 10.14 5 85930 48556 79609897
Transfusion 35.52 10.14 74 85861 21256 79637197
Weight increased 35.22 10.14 455 85480 276931 79381522
Chronic disease 34.82 10.14 11 85924 150 79658303
Vaginal haemorrhage 34.38 10.14 74 85861 21743 79636710
Fluid retention 33.78 10.14 157 85778 69652 79588801
Systemic lupus erythematosus 32.60 10.14 50 85885 121099 79537354
Suicide attempt 32.55 10.14 25 85910 82907 79575546
Interstitial lung disease 31.74 10.14 45 85890 112555 79545898
Agitation 31.04 10.14 37 85898 99678 79558775
Sleep disorder due to general medical condition, insomnia type 30.75 10.14 5 85930 43551 79614902
Iron deficiency anaemia 30.53 10.14 78 85857 25594 79632859
Uterine leiomyoma 30.20 10.14 36 85899 6407 79652046
Nasal congestion 29.86 10.14 162 85773 76390 79582063
Nephrogenic systemic fibrosis 29.83 10.14 35 85900 6125 79652328
Incorrect dose administered 29.78 10.14 162 85773 76468 79581985
Intestinal obstruction 29.72 10.14 108 85827 42912 79615541
Completed suicide 29.65 10.14 150 85785 245617 79412836
Leukopenia 29.55 10.14 50 85885 116463 79541990
Flatulence 29.30 10.14 107 85828 42617 79615836
Complication of device insertion 28.97 10.14 35 85900 6315 79652138
Drug level decreased 28.86 10.14 54 85881 14348 79644105
Choreoathetosis 28.65 10.14 19 85916 1551 79656902
Large intestine polyp 28.45 10.14 50 85885 12658 79645795
Intestinal resection 28.28 10.14 27 85908 3730 79654723
Eosinophilia 28.27 10.14 7 85928 45338 79613115
Drug level below therapeutic 28.04 10.14 43 85892 9727 79648726
Athetosis 27.64 10.14 9 85926 136 79658317
Full blood count decreased 27.37 10.14 77 85858 26742 79631711
C-reactive protein abnormal 27.33 10.14 9 85926 48358 79610095
Hyponatraemia 27.31 10.14 99 85836 177749 79480704
Abnormal faeces 27.10 10.14 37 85898 7534 79650919
Cardiac arrest 26.95 10.14 95 85840 172001 79486452
Flushing 26.85 10.14 175 85760 88093 79570360
Hospitalisation 26.36 10.14 183 85752 94053 79564400
Blood pressure increased 26.10 10.14 345 85590 211015 79447438
Complications of bone marrow transplant 25.75 10.14 13 85922 633 79657820
Coma 25.70 10.14 43 85892 100606 79557847
Device placement issue 25.46 10.14 16 85919 1191 79657262
Myringotomy 25.37 10.14 6 85929 24 79658429
Polyneuropathy in malignant disease 25.04 10.14 10 85925 278 79658175
Neurotoxicity 24.68 10.14 3 85932 32515 79625938
Headache 24.64 10.14 898 85037 652874 79005579
Normal newborn 24.47 10.14 34 85901 7038 79651415
Illness 24.29 10.14 107 85828 46404 79612049
Multiple organ dysfunction syndrome 24.19 10.14 59 85876 120187 79538266
Full blood count abnormal 24.16 10.14 97 85838 40377 79618076
Asthenia 23.92 10.14 721 85214 510968 79147485
Maternal exposure during pregnancy 23.64 10.14 238 85697 136300 79522153
Discomfort 23.46 10.14 64 85871 125553 79532900
Cerebral infarction 23.29 10.14 10 85925 45666 79612787
Rhinorrhoea 23.24 10.14 151 85784 75923 79582530
Urinary tract infection 23.12 10.14 420 85515 274092 79384361
Oropharyngeal pain 22.11 10.14 197 85738 109156 79549297
Drug reaction with eosinophilia and systemic symptoms 22.02 10.14 22 85913 64222 79594231
Hepatosplenic T-cell lymphoma 22.01 10.14 13 85922 865 79657588
Irritable bowel syndrome 21.70 10.14 21 85914 62220 79596233
Cytokine release syndrome 21.60 10.14 6 85929 35992 79622461
Maternal exposure before pregnancy 21.43 10.14 25 85910 4348 79654105
Iron deficiency 21.41 10.14 40 85895 10614 79647839
Uterine perforation 21.36 10.14 30 85905 6273 79652180
Device interaction 21.18 10.14 12 85923 738 79657715
Blood creatine phosphokinase increased 21.13 10.14 24 85911 66066 79592387
Wound 21.09 10.14 60 85875 116119 79542334
Confusional state 21.05 10.14 230 85705 317767 79340686
Therapeutic response shortened 20.76 10.14 50 85885 15813 79642640
Neutrophil count decreased 20.60 10.14 44 85891 93915 79564538
Myelosuppression 20.27 10.14 9 85926 40287 79618166
Malaise 20.20 10.14 680 85255 489189 79169264
Haemoglobin abnormal 20.18 10.14 31 85904 7023 79651430
Sedation 19.91 10.14 16 85919 51879 79606574
Preterm premature rupture of membranes 19.89 10.14 14 85921 1259 79657194
Muscle spasms 19.84 10.14 281 85654 174449 79484004
Depressed level of consciousness 19.78 10.14 47 85888 96605 79561848
Treatment failure 19.46 10.14 106 85829 170380 79488073
Hepatic cytolysis 19.43 10.14 3 85932 27148 79631305
Joint space narrowing 19.41 10.14 11 85924 677 79657776
Blood cholesterol increased 19.38 10.14 38 85897 83682 79574771
Blister 19.35 10.14 65 85870 119411 79539042
Heart rate decreased 19.34 10.14 136 85799 70180 79588273
Granuloma skin 19.14 10.14 35 85900 9139 79649314
Maternal exposure during breast feeding 19.07 10.14 19 85916 2766 79655687
Ischaemic stroke 19.01 10.14 6 85929 33125 79625328
Pancytopenia 18.95 10.14 103 85832 165642 79492811
Rectal haemorrhage 18.94 10.14 144 85791 76156 79582297
Allergy to metals 18.94 10.14 10 85925 535 79657918
Sopor 18.90 10.14 6 85929 33004 79625449
Cholestasis 18.85 10.14 17 85918 52092 79606361
Thrombocytopenia 18.71 10.14 189 85746 265070 79393383
Drug specific antibody present 18.70 10.14 29 85906 6623 79651830
Gastrointestinal inflammation 18.63 10.14 31 85904 7513 79650940
Coronary artery disease 18.61 10.14 26 85909 65448 79593005
Hip fracture 18.59 10.14 74 85861 30687 79627766
Pyrexia 18.45 10.14 574 85361 678135 78980318
Blood parathyroid hormone decreased 18.07 10.14 37 85898 10499 79647954
Embedded device 18.00 10.14 20 85915 3299 79655154
Polymenorrhoea 17.98 10.14 12 85923 990 79657463
Dyschezia 17.95 10.14 19 85916 2969 79655484
Cytomegalovirus infection 17.85 10.14 12 85923 42632 79615821
Sinus pain 17.69 10.14 21 85914 3721 79654732
Serum ferritin 17.50 10.14 3 85932 0 79658453
Arthralgia 17.47 10.14 768 85167 571035 79087418
Small intestinal stenosis 17.44 10.14 11 85924 824 79657629
Haemorrhage 17.33 10.14 162 85773 90956 79567497
Arthropod bite 17.27 10.14 32 85903 8439 79650014
Agranulocytosis 17.13 10.14 14 85921 45016 79613437
Postpartum haemorrhage 17.08 10.14 14 85921 1581 79656872
Vaginal infection 17.05 10.14 26 85909 5854 79652599
Complication of device removal 17.04 10.14 21 85914 3868 79654585
Intermenstrual bleeding 17.03 10.14 26 85909 5858 79652595
Acute myeloid leukaemia 17.01 10.14 6 85929 30879 79627574
Malignant neoplasm progression 16.96 10.14 82 85853 135908 79522545
Bowel movement irregularity 16.96 10.14 27 85908 6307 79652146
Natural killer cell count 16.92 10.14 4 85931 16 79658437
Dyspnoea 16.77 10.14 1104 84831 855921 78802532
Hypokalaemia 16.74 10.14 89 85846 143951 79514502
Amegakaryocytic thrombocytopenia 16.72 10.14 4 85931 17 79658436
Product use issue 16.61 10.14 318 85617 209504 79448949
Dizziness 16.50 10.14 709 85226 525732 79132721
Heart valve replacement 16.42 10.14 11 85924 913 79657540
Cerebral haemorrhage 16.30 10.14 23 85912 57650 79600803
Premature rupture of membranes 16.28 10.14 21 85914 4048 79654405
Electrocardiogram QT prolonged 16.17 10.14 47 85888 90339 79568114
Pre-eclampsia 16.15 10.14 28 85907 7013 79651440
Delivery 16.06 10.14 10 85925 732 79657721
Blood albumin decreased 16.02 10.14 60 85875 24183 79634270
Therapeutic product effect decreased 16.01 10.14 107 85828 163756 79494697
Dysmenorrhoea 15.92 10.14 18 85917 3027 79655426
Bone marrow failure 15.86 10.14 19 85916 51088 79607365
Chronic spontaneous urticaria 15.82 10.14 12 85923 1212 79657241
Polyp 15.75 10.14 30 85905 8077 79650376
Premature separation of placenta 15.63 10.14 12 85923 1234 79657219
Liver injury 15.58 10.14 23 85912 56591 79601862
Hepatic enzyme increased 15.55 10.14 124 85811 182486 79475967
Constipation 15.47 10.14 407 85528 282643 79375810
Neutropenic sepsis 15.35 10.14 5 85930 27059 79631394
Arthritis infective 15.33 10.14 30 85905 8241 79650212
Drug-induced liver injury 15.31 10.14 30 85905 66087 79592366
Stomatitis 15.27 10.14 94 85841 146663 79511790
Gamma-glutamyltransferase increased 15.26 10.14 22 85913 54658 79603795
Rash maculo-papular 15.22 10.14 23 85912 56055 79602398
Epilepsy 15.18 10.14 13 85922 40847 79617606
Extrapyramidal disorder 15.15 10.14 3 85932 22676 79635777
Splenomegaly 15.10 10.14 53 85882 20701 79637752
Fistula 15.06 10.14 39 85896 12901 79645552
Cardio-respiratory arrest 14.99 10.14 63 85872 108447 79550006
Toxic skin eruption 14.79 10.14 3 85932 22290 79636163
Uterine atony 14.66 10.14 6 85929 178 79658275
Pneumonitis 14.63 10.14 27 85908 60833 79597620
Dyskinesia 14.59 10.14 16 85919 44757 79613696
Peritonitis bacterial 14.56 10.14 32 85903 9535 79648918
Foreign body in reproductive tract 14.42 10.14 9 85926 662 79657791
Hyperparathyroidism secondary 14.38 10.14 16 85919 2644 79655809
Device breakage 14.35 10.14 34 85901 10641 79647812
Tumour lysis syndrome 14.34 10.14 4 85931 23935 79634518
Ill-defined disorder 14.31 10.14 31 85904 65844 79592609
Transferrin saturation decreased 14.29 10.14 11 85924 1135 79657318
Transaminases increased 14.26 10.14 21 85914 51722 79606731
Appetite disorder 14.26 10.14 28 85907 7711 79650742
Stress at work 14.25 10.14 11 85924 1140 79657313
Malabsorption 14.23 10.14 22 85913 5010 79653443
Body temperature fluctuation 14.23 10.14 19 85916 3788 79654665
Vessel puncture site pain 14.21 10.14 3 85932 6 79658447
Accidental overdose 14.21 10.14 13 85922 39568 79618885
Pregnancy 14.19 10.14 62 85873 26789 79631664
Neuroleptic malignant syndrome 14.11 10.14 6 85929 27553 79630900
Internal haemorrhage 13.96 10.14 30 85905 8803 79649650
Appendicectomy 13.95 10.14 16 85919 2732 79655721
Retching 13.93 10.14 46 85889 17421 79641032
Mobility decreased 13.92 10.14 76 85859 122099 79536354
Delayed haemolytic transfusion reaction 13.90 10.14 3 85932 7 79658446
Pulmonary arterial hypertension 13.87 10.14 64 85871 28302 79630151
Small intestine ulcer 13.85 10.14 9 85926 710 79657743
Mucosal inflammation 13.74 10.14 39 85896 75541 79582912
Abscess 13.69 10.14 55 85880 22896 79635557
Ventricular tachycardia 13.65 10.14 15 85920 41920 79616533
Respiratory failure 13.55 10.14 127 85808 180784 79477669
Diarrhoea haemorrhagic 13.51 10.14 38 85897 13196 79645257
Fibromyalgia 13.39 10.14 31 85904 64309 79594144
Cough 13.33 10.14 502 85433 366287 79292166
Hypervolaemia 13.20 10.14 85 85850 42605 79615848
Myopathy 13.16 10.14 3 85932 20560 79637893
Hepatitis 13.15 10.14 25 85910 55702 79602751
Skin induration 13.11 10.14 20 85915 4505 79653948
Gastric bypass 13.06 10.14 11 85924 1290 79657163
Vascular device infection 13.03 10.14 32 85903 10244 79648209
Posterior reversible encephalopathy syndrome 13.01 10.14 6 85929 26275 79632178
Dysarthria 12.96 10.14 34 85901 67588 79590865
Kidney infection 12.75 10.14 52 85883 21799 79636654
Drug ineffective 12.73 10.14 998 84937 1079915 78578538
Nasopharyngitis 12.72 10.14 361 85574 253520 79404933
Vascular stenosis 12.70 10.14 8 85927 598 79657855
Transferrin saturation increased 12.69 10.14 5 85930 134 79658319
Heart rate irregular 12.63 10.14 69 85866 32610 79625843
Respiratory arrest 12.57 10.14 27 85908 57523 79600930
Rectal tenesmus 12.54 10.14 12 85923 1663 79656790
Anal ulcer 12.51 10.14 11 85924 1367 79657086
Disorientation 12.47 10.14 31 85904 62745 79595708
Agitated depression 12.45 10.14 7 85928 424 79658029
Haemophagocytic lymphohistiocytosis 12.45 10.14 4 85931 21833 79636620
Aspartate aminotransferase increased 12.34 10.14 93 85842 138548 79519905
Chronic kidney disease 12.27 10.14 117 85818 66037 79592416
Sinus tachycardia 12.24 10.14 13 85922 36895 79621558
COVID-19 pneumonia 12.23 10.14 8 85927 28841 79629612
Skin warm 12.22 10.14 24 85911 6608 79651845
Panniculitis 12.12 10.14 35 85900 12336 79646117
Medication error 12.05 10.14 36 85899 68606 79589847
Left ventricular dysfunction 12.05 10.14 3 85932 19358 79639095
Vitamin D decreased 12.03 10.14 30 85905 9695 79648758
Gastroduodenal haemorrhage 11.96 10.14 6 85929 288 79658165
Arthritis 11.95 10.14 182 85753 114698 79543755
Swelling 11.95 10.14 163 85772 216548 79441905
Uterine infection 11.95 10.14 6 85929 289 79658164
Pancreatitis acute 11.93 10.14 22 85913 49582 79608871
Red blood cell count decreased 11.82 10.14 104 85831 57409 79601044
Breath sounds abnormal 11.78 10.14 41 85894 15943 79642510
Intercepted medication error 11.77 10.14 9 85926 920 79657533
Injection site pain 11.75 10.14 201 85734 129637 79528816
Serotonin syndrome 11.71 10.14 19 85916 45008 79613445
Gastrointestinal bacterial overgrowth 11.67 10.14 8 85927 690 79657763
Haematocrit decreased 11.65 10.14 109 85826 61203 79597250
Lactic acidosis 11.58 10.14 38 85897 70321 79588132
Bradycardia 11.56 10.14 92 85843 135465 79522988
Disseminated intravascular coagulation 11.47 10.14 13 85922 35829 79622624
Intestinal stenosis 11.45 10.14 17 85918 3737 79654716
Weight fluctuation 11.41 10.14 33 85902 11642 79646811
Calciphylaxis 11.40 10.14 17 85918 3753 79654700
Arthropathy 11.35 10.14 129 85806 176982 79481471
Cognitive disorder 11.35 10.14 38 85897 69888 79588565
Platelet count increased 11.28 10.14 51 85884 22355 79636098
Blood growth hormone increased 11.28 10.14 8 85927 728 79657725
Respiratory depression 11.26 10.14 8 85927 27622 79630831
Bronchiectasis 11.26 10.14 5 85930 22381 79636072
Hypersensitivity 11.19 10.14 207 85728 262032 79396421
Influenza 11.14 10.14 199 85736 129407 79529046
Viral infection 11.13 10.14 82 85853 42934 79615519
Septic shock 11.10 10.14 82 85853 122719 79535734
Abdominal abscess 11.03 10.14 24 85911 7103 79651350
Antineutrophil cytoplasmic antibody positive 11.02 10.14 10 85925 1296 79657157
Overlap syndrome 10.99 10.14 9 85926 1015 79657438
Alanine aminotransferase increased 10.98 10.14 117 85818 162453 79496000
Empty sella syndrome 10.76 10.14 4 85931 91 79658362
Pain in extremity 10.75 10.14 488 85447 364050 79294403
Chills 10.75 10.14 237 85698 159997 79498456
Sinus bradycardia 10.71 10.14 7 85928 25240 79633213
Basal cell carcinoma 10.70 10.14 73 85862 37302 79621151
Hepatocellular injury 10.67 10.14 22 85913 47571 79610882
Hot flush 10.65 10.14 98 85837 54779 79603674
Abnormal uterine bleeding 10.63 10.14 9 85926 1064 79657389
Cardiogenic shock 10.61 10.14 18 85917 41896 79616557
Infusion site swelling 10.60 10.14 25 85910 7801 79650652
Laryngeal stenosis 10.52 10.14 9 85926 1079 79657374
Insomnia 10.51 10.14 342 85593 244828 79413625
Subdural haematoma 10.51 10.14 11 85924 31423 79627030
Mydriasis 10.48 10.14 3 85932 17640 79640813
Acute myocardial infarction 10.47 10.14 45 85890 76991 79581462
Pelvic pain 10.46 10.14 35 85900 13346 79645107
Amniotic cavity infection 10.45 10.14 8 85927 819 79657634
Ileostomy 10.44 10.14 11 85924 1709 79656744
Intentional product misuse 10.40 10.14 60 85875 95105 79563348
Hypercholesterolaemia 10.35 10.14 6 85929 23089 79635364
Pregnancy on oral contraceptive 10.30 10.14 8 85927 837 79657616
Infusion site extravasation 10.29 10.14 29 85906 10079 79648374
Mean cell haemoglobin concentration decreased 10.23 10.14 18 85917 4561 79653892
Drug tolerance decreased 10.19 10.14 34 85901 12944 79645509
Myelofibrosis 10.16 10.14 13 85922 2487 79655966
Small intestinal obstruction 10.15 10.14 57 85878 27215 79631238
Vanishing bile duct syndrome 10.14 10.14 11 85924 1767 79656686

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11AA01 ALIMENTARY TRACT AND METABOLISM
VITAMINS
MULTIVITAMINS, COMBINATIONS
Multivitamins with minerals
ATC B03AE01 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in other combinations
ATC B03AE02 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in other combinations
ATC B03AE03 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in other combinations
ATC B03AE04 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in other combinations
MeSH PA D018977 Micronutrients
MeSH PA D014131 Trace Elements
CHEBI has role CHEBI:27027 trace elements
CHEBI has role CHEBI:76971 Escherichia coli metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Anemia of prematurity indication 47100003 DOID:11243
Megaloblastic anemia due to folate deficiency indication 85649008 DOID:14026
Iron deficiency anemia indication 87522002
Magnetic resonance imaging of liver indication 241622002
Peptic ulcer contraindication 13200003 DOID:750
Gastroenteritis contraindication 25374005 DOID:2326
Hemosiderosis contraindication 39011001 DOID:12119
Hemolytic anemia contraindication 61261009 DOID:583
Ulcerative colitis contraindication 64766004 DOID:8577
Diverticular disease contraindication 397881000
Hemochromatosis contraindication 399187006 DOID:2352
Repeated Blood Transfusions contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4017653 VUID
N0000146032 NUI
D09736 KEGG_DRUG
4017653 VANDF
4021247 VANDF
4021883 VANDF
C0337439 UMLSCUI
CHEBI:18248 CHEBI
D007501 MESH_DESCRIPTOR_UI
DB01592 DRUGBANK_ID
E1UOL152H7 UNII
23925 PUBCHEM_CID
262150 RXNORM
20159 MMSL
30873 MMSL
30874 MMSL
34448 MMSL
6958 MMSL
7441 MMSL
8219 MMSL
NOCODE MMSL
d04432 MMSL
000828 NDDF
007431 NDDF
30729008 SNOMEDCT_US
32954005 SNOMEDCT_US
3829006 SNOMEDCT_US
714781004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ferralet 90 HUMAN PRESCRIPTION DRUG LABEL 5 0178-0089 TABLET, FILM COATED 90 mg ORAL unapproved drug other 17 sections
Ferralet 90 HUMAN PRESCRIPTION DRUG LABEL 5 0178-0089 TABLET, FILM COATED 90 mg ORAL unapproved drug other 17 sections
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 60 mg ORAL Unapproved drug other 12 sections
CitraNatal Harmony 3.0 HUMAN PRESCRIPTION DRUG LABEL 8 0178-0796 CAPSULE, GELATIN COATED 27 mg ORAL unapproved drug other 10 sections
CitraNatal Harmony 3.0 HUMAN PRESCRIPTION DRUG LABEL 8 0178-0796 CAPSULE, GELATIN COATED 27 mg ORAL unapproved drug other 10 sections
Citranatal Harmony 2.1 HUMAN PRESCRIPTION DRUG LABEL 2 0178-0797 CAPSULE, GELATIN COATED 29 mg ORAL unapproved drug other 10 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 85 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 85 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 90 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 27 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 27 mg ORAL Unapproved drug other 9 sections
CitraNatal Medley HUMAN PRESCRIPTION DRUG LABEL 8 0178-0896 CAPSULE, GELATIN COATED 27 mg ORAL unapproved drug other 10 sections
CitraNatal Medley HUMAN PRESCRIPTION DRUG LABEL 8 0178-0896 CAPSULE, GELATIN COATED 27 mg ORAL unapproved drug other 10 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 27 mg ORAL Unapproved drug other 11 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 29 mg ORAL unapproved drug other 14 sections
Vitafol Caplet HUMAN PRESCRIPTION DRUG LABEL 12 0642-0072 CAPSULE 27 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 29 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol OB Caplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 65 mg ORAL Unapproved drug other 14 sections
Vitafol OB Caplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 65 mg ORAL Unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 27 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 29 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 29 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Nano HUMAN PRESCRIPTION DRUG LABEL 7 0642-0094 TABLET, COATED 18 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol Nano HUMAN PRESCRIPTION DRUG LABEL 7 0642-0094 TABLET, COATED 18 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 29 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Strovite Forte Caplet HUMAN PRESCRIPTION DRUG LABEL 19 0642-0204 TABLET, COATED 10 mg ORAL UNAPPROVED DRUG OTHER 15 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 16 0642-3010 CAPSULE, GELATIN COATED 29 mg ORAL unapproved drug other 7 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 90 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 90 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Polysaccharide-Iron HUMAN OTC DRUG LABEL 1 17714-077 CAPSULE 150 mg ORAL unapproved drug other 10 sections