mecobalamin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4600	13422-55-4

Description:

Molecule	Description
Synonyms: mecobalamin methycobal methyl cobalamine Methyl vitamin B12 methylcobalamin methylcobaz	Molecular weight: 1344.40 Formula: C63H91CoN13O14P CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 488.71 ALOGS: ROTB: None

Molecule

Description

Synonyms:

mecobalamin
methycobal
methyl cobalamine
Methyl vitamin B12
methylcobalamin
methylcobaz

Molecular weight: 1344.40
Formula: C63H91CoN13O14P
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 488.71
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
1.50	mg	O
0.20	mg	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hepatic function abnormal	150.26	15.17	88	8506	34333	46643135
Platelet count decreased	103.73	15.17	109	8485	99915	46577553
Interstitial lung disease	84.79	15.17	74	8520	53875	46623593
Neutrophil count decreased	77.31	15.17	64	8530	43362	46634106
Altered state of consciousness	74.67	15.17	49	8545	23299	46654169
Drug eruption	61.55	15.17	42	8552	21287	46656181
Cerebral infarction	46.99	15.17	37	8557	23329	46654139
White blood cell count decreased	46.48	15.17	78	8516	112153	46565315
Decreased appetite	43.21	15.17	104	8490	193732	46483736
Upper respiratory tract inflammation	42.99	15.17	17	8577	2778	46674690
Erythema multiforme	42.79	15.17	25	8569	9679	46667789
Renal impairment	42.47	15.17	60	8534	74312	46603156
Drug ineffective	42.04	15.17	38	8556	677800	45999668
Sudden hearing loss	40.44	15.17	13	8581	1165	46676303
Haemorrhage subcutaneous	38.92	15.17	16	8578	2890	46674578
Disseminated intravascular coagulation	38.01	15.17	30	8564	18975	46658493
Cardiac failure	36.37	15.17	58	8536	79890	46597578
Osteonecrosis of jaw	34.70	15.17	37	8557	34365	46643103
Herpes zoster	33.32	15.17	51	8543	67821	46609647
Pyrexia	26.88	15.17	131	8463	348671	46328797
Blood lactate dehydrogenase increased	26.07	15.17	25	8569	20475	46656993
Femoral neck fracture	25.87	15.17	17	8577	8086	46669382
Oral mucosa erosion	25.44	15.17	9	8585	1081	46676387
Blood urea increased	25.09	15.17	27	8567	25325	46652143
Liver disorder	24.19	15.17	32	8562	37214	46640254
Anaemia	24.11	15.17	102	8492	255677	46421791
Pancytopenia	23.78	15.17	50	8544	85008	46592460
Pneumonia bacterial	23.36	15.17	15	8579	6864	46670604
Aspartate aminotransferase increased	22.86	15.17	47	8547	78653	46598815
Toxic encephalopathy	22.20	15.17	13	8581	5049	46672419
Lymphocyte stimulation test positive	21.82	15.17	7	8587	623	46676845
Hypotension	21.47	15.17	8	8586	232581	46444887
Inappropriate antidiuretic hormone secretion	21.43	15.17	19	8575	14083	46663385
Spinal compression fracture	20.85	15.17	18	8576	12885	46664583
Joint swelling	20.65	15.17	3	8591	166070	46511398
Enterocolitis	19.84	15.17	13	8581	6155	46671313
Osteomyelitis	18.99	15.17	22	8572	22361	46655107
Toxicity to various agents	18.37	15.17	8	8586	211758	46465710
Febrile neutropenia	18.13	15.17	48	8546	94579	46582889
Dyspnoea	18.02	15.17	43	8551	515505	46161963
Malignant neoplasm progression	17.95	15.17	38	8556	64888	46612580
Hypocalcaemia	17.37	15.17	23	8571	26762	46650706
Completed suicide	17.32	15.17	3	8591	145917	46531551
Pneumonia	17.06	15.17	123	8471	376197	46301271
Pain	16.49	15.17	40	8554	476908	46200560
Blood pressure decreased	16.43	15.17	34	8560	57125	46620343
Hypoglycaemia	16.42	15.17	33	8561	54316	46623152
Lacrimation decreased	16.12	15.17	5	8589	399	46677069
Blood cholinesterase decreased	15.96	15.17	4	8590	145	46677323
Stomatitis	15.55	15.17	37	8557	68260	46609208

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Interstitial lung disease	161.91	16.20	131	7787	60066	29884494
Hepatic function abnormal	95.49	16.20	83	7835	41862	29902698
Platelet count decreased	93.45	16.20	127	7791	106002	29838558
Renal impairment	64.01	16.20	94	7824	84090	29860470
Cerebral infarction	61.61	16.20	53	7865	26320	29918240
White blood cell count decreased	54.32	16.20	87	7831	83860	29860700
Disseminated intravascular coagulation	52.68	16.20	45	7873	22126	29922434
Altered state of consciousness	52.66	16.20	43	7875	19876	29924684
Liver disorder	52.37	16.20	51	7867	29671	29914889
Neutrophil count decreased	48.63	16.20	58	7860	42396	29902164
Lymphocyte count decreased	39.90	16.20	36	7882	19019	29925541
Upper respiratory tract inflammation	37.00	16.20	15	7903	1816	29942744
Drug eruption	36.47	16.20	33	7885	17493	29927067
Fatigue	32.01	16.20	23	7895	320650	29623910
Dyslalia	28.98	16.20	9	7909	499	29944061
Enterocolitis	27.91	16.20	19	7899	6668	29937892
Toxicity to various agents	26.63	16.20	7	7911	177176	29767384
Drug ineffective	24.09	16.20	33	7885	340354	29604206
Decreased appetite	22.79	16.20	89	7829	149821	29794739
Hypopituitarism	22.05	16.20	10	7908	1592	29942968
Colorectal cancer	21.05	16.20	10	7908	1769	29942791
Inappropriate antidiuretic hormone secretion	20.85	16.20	20	7898	11402	29933158
C-reactive protein increased	20.19	16.20	39	7879	43434	29901126
Gastric ulcer haemorrhage	19.60	16.20	14	7904	5300	29939260
Herpes zoster	19.27	16.20	31	7887	29912	29914648
Paronychia	18.69	16.20	11	7907	3000	29941560
Blood lactate dehydrogenase increased	18.57	16.20	25	7893	20576	29923984
Febrile neutropenia	17.56	16.20	65	7853	106628	29837932
Hyperuricaemia	17.53	16.20	15	7903	7379	29937181
Pneumonia	17.44	16.20	149	7769	334157	29610403
Pyrexia	17.38	16.20	135	7783	294354	29650206
Male sexual dysfunction	16.88	16.20	5	7913	236	29944324
Erythema multiforme	16.54	16.20	15	7903	7970	29936590

Pharmacologic Action:

Source	Code	Description
ATC	B03BA05	BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS VITAMIN B12 AND FOLIC ACID Vitamin B12 (cyanocobalamin and analogues)
CHEBI has role	CHEBI:23357	cofactor
CHEBI has role	CHEBI:75771	mus musculus metabolite
CHEBI has role	CHEBI:77746	h. sapiens metabolites

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Prevention of Vitamin B12 Deficiency	indication
Hypokalemia	contraindication	43339004
Gastrectomy	contraindication	53442002
Leber's optic atrophy	contraindication	58610003	DOID:705
Atrophic gastritis	contraindication	84568007	DOID:8929

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D03246	KEGG_DRUG
4024930	VUID
N0000179178	NUI
4024930	VANDF
C0065844	UMLSCUI
CHEBI:28115	CHEBI
CHEMBL2359370	ChEMBL_ID
CHEMBL4297672	ChEMBL_ID
CHEMBL2448537	ChEMBL_ID
DB03614	DRUGBANK_ID
C019476	MESH_SUPPLEMENTAL_RECORD_UI
3148	INN_ID
BR1SN1JS2W	UNII
6474318	PUBCHEM_CID
29421	RXNORM
295772	MMSL
29966	MMSL
338725	MMSL
60213	MMSL
NOCODE	MMSL
d05311	MMSL
007745	NDDF
259512006	SNOMEDCT_US
714678000	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Organdrainex	HUMAN OTC DRUG LABEL	13	44911-0457	LIQUID	3 [hp_X]	ORAL	unapproved drug other	9 sections
healthy mamaBE WELL ROUNDED BE WELL ROUNDED	HUMAN PRESCRIPTION DRUG LABEL	17	58154-107	TABLET, FILM COATED	8 ug	ORAL	unapproved drug other	8 sections
Vita-Rx Diabetic Vitamin	HUMAN PRESCRIPTION DRUG LABEL	14	65121-301	CAPSULE, GELATIN COATED	0.00 mg	ORAL	unapproved drug other	5 sections
Methaver	HUMAN PRESCRIPTION DRUG LABEL	5	69336-353	CAPSULE	2 mg	ORAL	unapproved drug other	13 sections
Vita-Rx Diabetic Vitamin	HUMAN PRESCRIPTION DRUG LABEL	14	69677-050	CAPSULE, GELATIN COATED	0.00 mg	ORAL	unapproved drug other	5 sections
B-Combo	HUMAN PRESCRIPTION DRUG LABEL	6	70104-110	INJECTION	1 mg	INTRAMUSCULAR	unapproved drug other	1 sections
Lipovite	HUMAN PRESCRIPTION DRUG LABEL	13	70104-128	INJECTION	1 mg	INTRAMUSCULAR	unapproved drug other	1 sections
MIC B12	HUMAN PRESCRIPTION DRUG LABEL	4	70104-806	INJECTION	1 mg	INTRAMUSCULAR	unapproved drug other	1 sections
Methylcobalamin	HUMAN PRESCRIPTION DRUG LABEL	1	70104-826	INJECTION	1 mg	INTRAMUSCULAR	unapproved drug other	1 sections
Zyrexal	HUMAN PRESCRIPTION DRUG LABEL	8	72380-915	TABLET	1 mg	ORAL	unapproved drug other	8 sections
Folinex	HUMAN PRESCRIPTION DRUG LABEL	4	72380-916	CAPSULE	1 mg	ORAL	unapproved drug other	8 sections