All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

mecobalamin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	4600	13422-55-4

Description:

Molecule	Description
Synonyms: mecobalamin methycobal methyl cobalamine Methyl vitamin B12 methylcobalamin methylcobaz	Molecular weight: 1344.40 Formula: C63H91CoN13O14P CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 488.71 ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
1.50	mg	O
0.20	mg	P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pemphigus	145.75	9.33	13	53654	326851	90247929
Hand deformity	143.05	9.33	8	53659	296354	90278426
Systemic lupus erythematosus	127.62	9.33	29	53638	361867	90212913
Treatment failure	125.50	9.33	16	53651	303912	90270868
Platelet count decreased	110.54	9.33	248	53419	136721	90438059
Contraindicated product administered	106.37	9.33	29	53638	320110	90254670
Synovitis	103.84	9.33	33	53634	329719	90245061
Product use in unapproved indication	100.08	9.33	37	53630	336199	90238581
Drug ineffective	97.54	9.33	456	53211	1383842	89190938
Diarrhoea	93.93	9.33	907	52760	938283	89636497
Helicobacter infection	91.11	9.33	13	53654	226837	90347943
Duodenal ulcer perforation	90.48	9.33	12	53655	221276	90353504
Rheumatoid factor positive	88.17	9.33	3	53664	171647	90403133
Maternal exposure during pregnancy	86.68	9.33	53	53614	360010	90214770
Off label use	86.09	9.33	349	53318	1101903	89472877
Product use issue	84.51	9.33	45	53622	329874	90244906
Drug intolerance	83.68	9.33	85	53582	447506	90127274
Pericarditis	81.61	9.33	29	53638	270122	90304658
Arthropathy	81.30	9.33	59	53608	366183	90208597
Fall	81.01	9.33	525	53142	481285	90093495
Glossodynia	77.95	9.33	47	53620	321732	90253048
Rheumatic fever	77.52	9.33	3	53664	153118	90421662
Therapeutic product effect decreased	73.85	9.33	36	53631	277535	90297245
Wound	72.35	9.33	45	53622	302935	90271845
Product dose omission issue	70.91	9.33	351	53316	291336	90283444
Toxicity to various agents	68.38	9.33	43	53624	287803	90286977
White blood cell count decreased	67.38	9.33	235	53432	166874	90407906
Drug hypersensitivity	66.98	9.33	107	53560	463502	90111278
Neutrophil count decreased	63.92	9.33	135	53532	71397	90503383
C-reactive protein abnormal	62.83	9.33	3	53664	127426	90447354
Intentional product use issue	62.62	9.33	25	53642	216867	90357913
Anti-cyclic citrullinated peptide antibody positive	60.89	9.33	32	53635	236401	90338379
Sleep disorder due to general medical condition, insomnia type	60.47	9.33	4	53663	128690	90446090
Unevaluable event	60.43	9.33	113	53554	54735	90520045
Ill-defined disorder	59.07	9.33	18	53649	184873	90389907
Muscle injury	58.64	9.33	16	53651	176638	90398142
Device expulsion	57.77	9.33	94	53573	40792	90533988
Infusion related reaction	57.57	9.33	99	53568	416681	90158099
Muscle spasms	56.92	9.33	297	53370	251586	90323194
Type 2 diabetes mellitus	56.15	9.33	25	53642	203219	90371561
Deep vein thrombosis	55.87	9.33	149	53518	91471	90483309
Discomfort	54.84	9.33	49	53618	274286	90300494
Dizziness	53.30	9.33	558	53109	588726	89986054
Plasma cell myeloma	51.20	9.33	89	53578	40739	90534041
Neuropathy peripheral	50.42	9.33	187	53480	136783	90437997
Dehydration	50.09	9.33	238	53429	194209	90380571
Lower respiratory tract infection	48.64	9.33	46	53621	250613	90324167
Fibromyalgia	46.03	9.33	33	53634	206236	90368544
Pneumonia	45.93	9.33	578	53089	637481	89937299
Full blood count decreased	44.33	9.33	70	53597	29619	90545161
Hypocholesterolaemia	44.17	9.33	34	53633	6415	90568365
Device dislocation	43.96	9.33	72	53595	31410	90543370
Anaemia	43.40	9.33	357	53310	352445	90222335
Liver injury	42.57	9.33	24	53643	170543	90404237
Alopecia	42.17	9.33	151	53516	494920	90079860
Hypersensitivity	41.91	9.33	134	53533	454543	90120237
Joint swelling	41.89	9.33	155	53512	503145	90071635
Feeling abnormal	41.84	9.33	203	53464	167032	90407748
Haemoglobin decreased	41.54	9.33	198	53469	161758	90413022
Therapy cessation	41.41	9.33	76	53591	36285	90538495
Hepatic function abnormal	39.78	9.33	86	53581	46202	90528578
Therapeutic product effect incomplete	39.50	9.33	34	53633	193862	90380918
Hepatic enzyme increased	39.38	9.33	98	53569	360638	90214142
Urinary tract infection	37.43	9.33	309	53358	305323	90269457
Gastrointestinal disorder	37.25	9.33	59	53608	256628	90318152
Prescribed overdose	36.06	9.33	7	53660	97618	90477162
Folliculitis	35.70	9.33	41	53626	204312	90370468
Hypercholesterolaemia	33.73	9.33	9	53658	100883	90473897
General physical health deterioration	33.17	9.33	104	53563	355011	90219769
Constipation	33.01	9.33	281	53386	280114	90294666
Swelling	32.95	9.33	132	53535	418926	90155854
Infection	31.78	9.33	109	53558	361985	90212795
Nausea	31.29	9.33	869	52798	1109447	89465333
Intentional overdose	30.20	9.33	9	53658	93825	90480955
Flatulence	30.14	9.33	72	53595	41295	90533485
Mobility decreased	29.85	9.33	65	53602	250669	90324111
Grip strength decreased	29.58	9.33	9	53658	92567	90482213
Asthenia	29.27	9.33	461	53206	533290	90041490
Facet joint syndrome	28.95	9.33	11	53656	98378	90476402
Rheumatoid arthritis	28.01	9.33	115	53552	362499	90212281
Irritable bowel syndrome	27.06	9.33	51	53616	207397	90367383
Condition aggravated	26.70	9.33	225	53442	595320	89979460
Aspartate aminotransferase increased	26.49	9.33	126	53541	102811	90471969
Blister	26.48	9.33	71	53596	254927	90319853
Heart sounds	26.09	9.33	13	53654	1131	90573649
Spinal compression fracture	25.78	9.33	38	53629	15140	90559640
Pulmonary embolism	25.32	9.33	148	53519	130672	90444108
Prolonged expiration	24.93	9.33	13	53654	1244	90573536
Back pain	24.77	9.33	292	53375	316883	90257897
Deep vein thrombosis postoperative	24.28	9.33	6	53661	70803	90503977
Pulmonary fibrosis	24.23	9.33	17	53650	107486	90467294
Injection site erythema	24.21	9.33	119	53548	98383	90476397
Hot flush	23.38	9.33	83	53584	59405	90515375
Adjustment disorder with depressed mood	23.37	9.33	3	53664	56750	90518030
Fatigue	23.28	9.33	868	52799	1153155	89421625
Asthma	23.25	9.33	70	53597	242090	90332690
Headache	22.78	9.33	670	52997	862076	89712704
Injection site mass	22.46	9.33	44	53623	22046	90552734
Psoriasis	22.33	9.33	157	53510	147597	90427183
Blood potassium decreased	21.77	9.33	70	53597	47657	90527123
Musculoskeletal stiffness	21.69	9.33	96	53571	296436	90278344
Confusional state	21.58	9.33	137	53530	386068	90188712
Injection site pain	21.44	9.33	176	53491	173523	90401257
Lip dry	21.42	9.33	17	53650	100938	90473842
Wheezing	21.33	9.33	71	53596	238009	90336771
Illness	21.22	9.33	11	53656	81958	90492822
Dyspnoea exertional	21.22	9.33	92	53575	72196	90502584
Nasal congestion	20.66	9.33	101	53566	83313	90491467
Pleural effusion	20.58	9.33	125	53542	111866	90462914
Tremor	20.44	9.33	158	53509	153015	90421765
Pelvic pain	19.94	9.33	34	53633	15323	90559457
Sleep disorder	19.91	9.33	56	53611	197974	90376806
Abdominal discomfort	19.76	9.33	184	53483	477144	90097636
Impaired healing	19.53	9.33	72	53595	234127	90340653
Injection site haemorrhage	19.26	9.33	48	53619	28270	90546510
Bone erosion	19.16	9.33	4	53663	53017	90521763
Atrial fibrillation	19.05	9.33	140	53527	133471	90441309
Multiple sclerosis relapse	18.89	9.33	71	53596	52234	90522546
Autoimmune disorder	18.85	9.33	11	53656	76733	90498047
Hypertension	18.66	9.33	177	53490	457355	90117425
Obesity	18.60	9.33	21	53646	105486	90469294
Bursitis	18.39	9.33	31	53636	131623	90443157
Brain natriuretic peptide increased	18.10	9.33	20	53647	5985	90568795
Pain	17.75	9.33	452	53215	995889	89578891
Product complaint	17.67	9.33	30	53637	13470	90561310
COVID-19	17.53	9.33	47	53620	168796	90405984
X-ray abnormal	17.32	9.33	3	53664	45421	90529359
Vaginal haemorrhage	17.21	9.33	49	53618	31222	90543558
Dysgeusia	17.07	9.33	69	53598	52491	90522289
Adverse event	17.01	9.33	27	53640	117391	90457389
C-reactive protein increased	17.00	9.33	53	53614	181336	90393444
Laboratory test abnormal	16.97	9.33	59	53608	41795	90532985
Cerebral infarction	16.96	9.33	44	53623	26552	90548228
Hypoxia	16.76	9.33	86	53581	72313	90502467
Decreased appetite	16.55	9.33	314	53353	376226	90198554
Blood bilirubin increased	16.53	9.33	60	53607	43410	90531370
Pollakiuria	16.52	9.33	50	53617	32955	90541825
Pulmonary arterial hypertension	16.37	9.33	43	53624	26144	90548636
Influenza like illness	16.12	9.33	92	53575	80519	90494261
Red blood cell count decreased	15.98	9.33	62	53605	46289	90528491
Upper respiratory tract inflammation	15.96	9.33	13	53654	2659	90572121
Hip arthroplasty	15.96	9.33	13	53654	76195	90498585
Intentional product misuse	15.61	9.33	18	53649	89586	90485194
Hip fracture	15.53	9.33	49	53618	33028	90541752
Eye swelling	15.16	9.33	45	53622	29341	90545439
Respiration abnormal	15.09	9.33	21	53646	7942	90566838
Occult blood positive	14.98	9.33	15	53652	4008	90570772
Cardiac failure congestive	14.98	9.33	105	53562	98589	90476191
Wound infection	14.91	9.33	25	53642	106377	90468403
Hypervolaemia	14.90	9.33	48	53619	32709	90542071
Chest discomfort	14.88	9.33	136	53531	138229	90436551
Drug interaction	14.45	9.33	100	53567	276353	90298427
Thrombosis	14.25	9.33	83	53584	73168	90501612
Skin discolouration	14.25	9.33	58	53609	44257	90530523
Sciatica	14.04	9.33	24	53643	101358	90473422
Oedema peripheral	13.81	9.33	222	53445	257693	90317087
Vision blurred	13.74	9.33	112	53555	110181	90464599
Tinea infection	13.68	9.33	9	53658	1327	90573453
Flushing	13.35	9.33	94	53573	88397	90486383
Pulmonary hypertension	13.16	9.33	55	53612	42468	90532312
Coeliac disease	13.10	9.33	5	53662	44605	90530175
Exposure during pregnancy	13.08	9.33	85	53582	238325	90336455
Depression	12.97	9.33	250	53417	300351	90274429
Inflammation	12.94	9.33	58	53609	178534	90396246
Overdose	12.81	9.33	49	53618	157660	90417120
Rash pruritic	12.79	9.33	88	53579	82126	90492654
Osteoarthritis	12.76	9.33	66	53601	195664	90379116
Tooth disorder	12.75	9.33	44	53623	31046	90543734
Administration site swelling	12.74	9.33	9	53658	1490	90573290
Myalgia	12.68	9.33	159	53508	174966	90399814
Plasma cell myeloma recurrent	12.60	9.33	14	53653	4214	90570566
Acne	12.27	9.33	41	53626	28466	90546314
Transfusion	12.27	9.33	30	53637	17458	90557322
Pelvic abscess	12.27	9.33	10	53657	2048	90572732
Suicide attempt	12.24	9.33	16	53651	75383	90499397
Onychomadesis	12.17	9.33	6	53661	45992	90528788
Cardiac disorder	12.09	9.33	66	53601	56806	90517974
Injection site induration	12.07	9.33	22	53645	10446	90564334
Cellulitis	12.06	9.33	94	53573	91243	90483537
Drug ineffective for unapproved indication	12.04	9.33	13	53654	66631	90508149
Interstitial lung disease	12.02	9.33	82	53585	76323	90498457
Erythema multiforme	11.98	9.33	24	53643	12222	90562558
Aortic aneurysm rupture	11.76	9.33	6	53661	549	90574231
Herpes zoster	11.73	9.33	96	53571	94548	90480232
Depressive symptom	11.64	9.33	15	53652	5270	90569510
Live birth	11.64	9.33	18	53649	79089	90495691
Foot deformity	11.50	9.33	11	53656	59640	90515140
Haemorrhage subcutaneous	11.45	9.33	12	53655	3384	90571396
Flank pain	11.45	9.33	31	53636	19191	90555589
Haematocrit decreased	11.34	9.33	52	53615	41780	90533000
Intestinal dilatation	11.26	9.33	10	53657	2300	90572480
Balance disorder	11.25	9.33	97	53570	96983	90477797
Body height decreased	11.19	9.33	23	53644	11926	90562854
Femoral neck fracture	11.16	9.33	21	53646	10212	90564568
Heavy menstrual bleeding	11.13	9.33	32	53635	20498	90554282
Endometriosis	11.13	9.33	16	53651	6232	90568548
Renal impairment	11.02	9.33	103	53564	105318	90469462
Sudden hearing loss	10.85	9.33	8	53659	1415	90573365
Breast cancer stage III	10.79	9.33	21	53646	84426	90490354
Therapy non-responder	10.76	9.33	43	53624	136661	90438119
Dry skin	10.73	9.33	89	53578	87984	90486796
Hospice care	10.69	9.33	20	53647	9684	90565096
Weight decreased	10.52	9.33	297	53370	379613	90195167
Blood cholesterol increased	10.50	9.33	76	53591	207936	90366844
Drug tolerance decreased	10.49	9.33	3	53664	32127	90542653
Cardiac pacemaker insertion	10.49	9.33	13	53654	4394	90570386
Laryngeal pain	10.45	9.33	13	53654	4409	90570371
Blood pressure decreased	10.40	9.33	78	53589	74817	90499963
Faeces discoloured	10.39	9.33	32	53635	21288	90553492
Visual acuity reduced	10.37	9.33	34	53633	23376	90551404
Uterine leiomyoma	10.28	9.33	21	53646	10843	90563937
Fluid retention	10.20	9.33	88	53579	88003	90486777
Pneumonia bacterial	10.12	9.33	23	53644	12767	90562013
International normalised ratio increased	10.12	9.33	55	53612	47261	90527519
Chills	10.06	9.33	121	53546	131860	90442920
Hypophagia	9.99	9.33	45	53622	35892	90538888
Gallbladder disorder	9.91	9.33	30	53637	19773	90555007
Dysstasia	9.88	9.33	35	53632	25017	90549763
Lymphocyte count decreased	9.82	9.33	44	53623	35006	90539774
Cough	9.81	9.33	287	53380	368675	90206105
Multiple allergies	9.60	9.33	25	53642	15121	90559659
Drug eruption	9.59	9.33	44	53623	35363	90539417
Knee arthroplasty	9.53	9.33	22	53645	83160	90491620
Infusion site nodule	9.50	9.33	8	53659	1715	90573065
Brain tumour operation	9.46	9.33	3	53664	78	90574702
Bone pain	9.44	9.33	66	53601	61917	90512863
Concomitant disease aggravated	9.44	9.33	21	53646	11497	90563283
Osteonecrosis of jaw	9.43	9.33	47	53620	39056	90535724
Foetal exposure during pregnancy	9.42	9.33	7	53660	42968	90531812
Injection site atrophy	9.41	9.33	6	53661	838	90573942
Pulmonary oedema	9.39	9.33	66	53601	62014	90512766
Gastrointestinal haemorrhage	9.34	9.33	88	53579	90160	90484620
Red blood cell sedimentation rate increased	9.34	9.33	22	53645	82573	90492207

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Off label use	92.33	11.16	230	33133	638105	41949867
Product use in unapproved indication	85.09	11.16	20	33343	184436	42403536
White blood cell count decreased	74.15	11.16	222	33141	110174	42477798
Platelet count decreased	73.48	11.16	257	33106	138324	42449648
Drug abuse	69.18	11.16	3	33360	104768	42483204
Plasma cell myeloma	64.93	11.16	126	33237	47452	42540520
Drug ineffective	62.56	11.16	268	33095	629929	41958043
Pneumonia	60.36	11.16	548	32815	421601	42166371
Toxicity to various agents	57.25	11.16	57	33306	229079	42358893
Completed suicide	49.62	11.16	8	33355	96457	42491515
Fall	43.37	11.16	323	33040	234197	42353775
Diarrhoea	43.25	11.16	550	32813	460299	42127673
Decreased appetite	38.56	11.16	271	33092	192866	42395106
Drug interaction	36.96	11.16	98	33265	266901	42321071
Full blood count decreased	35.08	11.16	60	33303	20500	42567472
General physical health deterioration	30.92	11.16	44	33319	151202	42436770
Constipation	27.43	11.16	219	33144	162072	42425900
Laboratory test abnormal	26.76	11.16	57	33306	22921	42565051
Treatment failure	26.54	11.16	8	33355	62616	42525356
Interstitial lung disease	25.31	11.16	125	33238	78337	42509635
Male sexual dysfunction	25.15	11.16	10	33353	382	42587590
Asthenia	24.91	11.16	332	33031	280461	42307511
Rash	24.80	11.16	328	33035	276626	42311346
Upper respiratory tract inflammation	23.53	11.16	16	33347	1880	42586092
Neuropathy peripheral	23.35	11.16	148	33215	101705	42486267
Fatigue	23.03	11.16	473	32890	435168	42152804
Dizziness	22.64	11.16	296	33067	248958	42339014
Drug ineffective for unapproved indication	21.26	11.16	5	33358	46158	42541814
Overdose	21.13	11.16	31	33332	105233	42482739
Coma	20.69	11.16	8	33355	53546	42534426
Haemoglobin decreased	19.83	11.16	174	33189	132297	42455675
Intentional product misuse	19.73	11.16	12	33351	61888	42526084
Intentional overdose	19.36	11.16	8	33355	51448	42536524
Neutrophil count decreased	19.02	11.16	99	33264	63316	42524656
Hepatic function abnormal	18.69	11.16	85	33278	51482	42536490
Cellulitis	18.37	11.16	96	33267	61489	42526483
Cataract nuclear	18.37	11.16	10	33353	787	42587185
Intentional product use issue	17.75	11.16	18	33345	71815	42516157
Muscular weakness	17.71	11.16	119	33244	83379	42504593
Multiple organ dysfunction syndrome	17.21	11.16	31	33332	97004	42490968
Product dose omission issue	16.45	11.16	189	33174	154176	42433796
Cholestasis	16.30	11.16	3	33360	32876	42555096
Hypopituitarism	16.09	11.16	15	33348	2776	42585196
Influenza	15.92	11.16	93	33270	62082	42525890
Tinea pedis	15.81	11.16	13	33350	2035	42585937
Viral infection	15.81	11.16	46	33317	22437	42565535
Spinal compression fracture	15.71	11.16	24	33339	7459	42580513
Sideroblastic anaemia	15.64	11.16	7	33356	360	42587612
Adverse drug reaction	15.32	11.16	64	33299	37370	42550602
Foetal exposure during pregnancy	15.31	11.16	9	33354	47302	42540670
Hiccups	15.11	11.16	31	33332	12140	42575832
Dehydration	14.84	11.16	173	33190	141594	42446378
Pleural effusion	14.73	11.16	128	33235	97038	42490934
Eosinophilia	14.31	11.16	4	33359	32895	42555077
COVID-19	14.22	11.16	45	33318	115903	42472069
Condition aggravated	13.80	11.16	134	33229	260620	42327352
Sinusitis	13.61	11.16	73	33290	47219	42540753
Hypoaesthesia	13.48	11.16	99	33264	71364	42516608
Red blood cell count decreased	13.44	11.16	56	33307	32659	42555313
Psoriasis	13.30	11.16	74	33289	48530	42539442
Cataract	13.05	11.16	53	33310	30551	42557421
Cardiogenic shock	12.69	11.16	6	33357	35634	42552338
Oedema peripheral	12.49	11.16	162	33201	135914	42452058
Muscle spasms	12.34	11.16	112	33251	85932	42502040
Leukopenia	12.27	11.16	25	33338	74721	42513251
Feeling abnormal	12.22	11.16	95	33268	69691	42518281
Contusion	12.21	11.16	65	33298	41920	42546052
Flatulence	11.90	11.16	45	33318	25107	42562865
Lower respiratory tract infection	11.78	11.16	9	33354	41197	42546775
Haematocrit decreased	11.52	11.16	56	33307	34852	42553120
Urinary occult blood	11.20	11.16	3	33360	31	42587941

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Platelet count decreased	184.28	9.82	443	72297	230000	110286559
Product use in unapproved indication	157.84	9.82	49	72691	447328	110069231
Drug ineffective	149.70	9.82	508	72232	1520032	108996527
Off label use	145.08	9.82	505	72235	1499680	109016879
Treatment failure	132.61	9.82	14	72726	277220	110239339
Completed suicide	124.71	9.82	9	72731	242372	110274187
Toxicity to various agents	121.14	9.82	84	72656	480471	110036088
Drug intolerance	115.06	9.82	62	72678	406450	110110109
Hand deformity	109.91	9.82	9	72731	218497	110298062
White blood cell count decreased	109.53	9.82	366	72374	229024	110287535
Plasma cell myeloma	100.53	9.82	162	72578	62774	110453785
Drug abuse	96.03	9.82	5	72735	177406	110339153
Fall	95.83	9.82	702	72038	602780	109913779
Pemphigus	94.90	9.82	14	72726	214556	110302003
Synovitis	91.40	9.82	33	72707	274059	110242500
Neutrophil count decreased	90.73	9.82	227	72513	120714	110395845
Pneumonia	90.08	9.82	926	71814	875788	109640771
Drug hypersensitivity	89.53	9.82	100	72640	453990	110062569
Systemic lupus erythematosus	89.37	9.82	28	72712	254310	110262249
Contraindicated product administered	80.91	9.82	31	72709	248236	110268323
Diarrhoea	78.31	9.82	1115	71625	1138390	109378169
Helicobacter infection	73.56	9.82	15	72725	181862	110334697
Rheumatoid factor positive	73.55	9.82	3	72737	131637	110384922
Duodenal ulcer perforation	73.25	9.82	14	72726	177686	110338873
Intentional product use issue	69.82	9.82	38	72702	247868	110268691
Dizziness	68.09	9.82	730	72010	697463	109819096
Product use issue	67.82	9.82	63	72677	311632	110204927
Hepatic function abnormal	67.38	9.82	168	72572	89127	110427432
Rheumatic fever	64.65	9.82	4	72736	122575	110393984
Arthropathy	63.88	9.82	57	72683	287465	110229094
Dehydration	63.31	9.82	356	72384	279155	110237404
Device expulsion	62.81	9.82	89	72651	30802	110485757
Maternal exposure during pregnancy	57.25	9.82	50	72690	254833	110261726
Haemoglobin decreased	57.12	9.82	318	72422	248409	110268150
Ill-defined disorder	55.57	9.82	17	72723	156836	110359723
Decreased appetite	54.74	9.82	515	72225	475331	110041228
Pericarditis	54.22	9.82	39	72701	219075	110297484
Sleep disorder due to general medical condition, insomnia type	54.10	9.82	4	72736	105639	110410920
Lower respiratory tract infection	53.03	9.82	49	72691	243057	110273502
Fibromyalgia	51.41	9.82	24	72716	170885	110345674
Therapeutic product effect decreased	51.25	9.82	51	72689	244265	110272294
Anti-cyclic citrullinated peptide antibody positive	49.64	9.82	29	72711	181955	110334604
Joint swelling	49.61	9.82	139	72601	442706	110073853
Interstitial lung disease	49.38	9.82	202	72538	139132	110377427
Muscle injury	48.56	9.82	16	72724	140791	110375768
Product dose omission issue	48.49	9.82	370	72370	321412	110195147
Drug interaction	47.59	9.82	169	72571	500014	110016545
Deep vein thrombosis	47.37	9.82	200	72540	139687	110376872
General physical health deterioration	47.26	9.82	134	72606	425161	110091398
Infusion related reaction	45.43	9.82	116	72624	381046	110135513
Anaemia	45.15	9.82	554	72186	546532	109970027
Glossodynia	44.69	9.82	48	72692	221956	110294603
Intentional overdose	44.07	9.82	16	72724	132485	110384074
Spinal compression fracture	43.47	9.82	57	72683	18335	110498224
Gastrointestinal disorder	42.67	9.82	58	72682	241894	110274665
Hypocholesterolaemia	41.14	9.82	34	72706	6387	110510172
Upper respiratory tract inflammation	40.91	9.82	29	72711	4342	110512217
Type 2 diabetes mellitus	40.73	9.82	34	72706	177198	110339361
Therapeutic product effect incomplete	38.12	9.82	55	72685	223750	110292809
Intentional product misuse	37.95	9.82	20	72720	132884	110383675
Therapy cessation	37.69	9.82	88	72652	44769	110471790
Asthenia	37.53	9.82	649	72091	688350	109828209
Full blood count decreased	37.46	9.82	72	72668	32027	110484532
Hypersensitivity	37.42	9.82	138	72602	403860	110112699
Device dislocation	36.86	9.82	71	72669	31633	110484926
Illness	34.88	9.82	6	72734	82165	110434394
Wound	34.87	9.82	63	72677	234374	110282185
Pleural effusion	34.83	9.82	218	72522	177491	110339068
Discomfort	34.41	9.82	55	72685	214652	110301907
Mobility decreased	34.25	9.82	65	72675	237357	110279202
Condition aggravated	34.10	9.82	314	72426	734522	109782037
Feeling abnormal	33.76	9.82	219	72521	180492	110336067
Facet joint syndrome	33.39	9.82	11	72729	96817	110419742
Cerebral infarction	32.45	9.82	91	72649	51747	110464812
Liver injury	31.99	9.82	31	72709	150382	110366177
Constipation	31.98	9.82	368	72372	357418	110159141
Muscle spasms	31.91	9.82	301	72439	277856	110238703
Rheumatoid arthritis	31.38	9.82	97	72643	299516	110217043
Alopecia	30.96	9.82	129	72611	364624	110151935
Overdose	30.34	9.82	68	72672	233726	110282833
Aspartate aminotransferase increased	29.98	9.82	194	72546	159742	110356817
Neuropathy peripheral	29.75	9.82	211	72529	179066	110337493
Unevaluable event	29.56	9.82	96	72644	59131	110457428
Hepatic enzyme increased	29.45	9.82	110	72630	320782	110195777
Male sexual dysfunction	28.79	9.82	10	72730	311	110516248
Drug ineffective for unapproved indication	28.59	9.82	16	72724	102822	110413737
Prescribed overdose	28.41	9.82	11	72729	87570	110428989
Cellulitis	28.16	9.82	160	72580	125856	110390703
Urinary tract infection	28.00	9.82	333	72407	325949	110190610
Multiple sclerosis relapse	27.43	9.82	84	72656	50156	110466403
Folliculitis	26.81	9.82	43	72697	167610	110348949
Grip strength decreased	26.12	9.82	10	72730	80164	110436395
COVID-19	25.90	9.82	79	72661	244981	110271578
Haematocrit decreased	25.13	9.82	98	72642	66019	110450540
Heart sounds	24.81	9.82	13	72727	1130	110515429
Asthma	24.15	9.82	84	72656	250207	110266352
Cardiac failure congestive	24.06	9.82	176	72564	150824	110365735
Swelling	24.05	9.82	134	72606	350907	110165652
Obesity	23.37	9.82	24	72716	113327	110403232
Lip dry	23.24	9.82	19	72721	100064	110416495
Dyspnoea exertional	23.17	9.82	132	72608	103928	110412631
Flatulence	22.92	9.82	81	72659	52068	110464491
Lymphocyte count decreased	22.70	9.82	86	72654	57157	110459402
Sleep disorder	22.47	9.82	62	72678	198582	110317977
Red blood cell count decreased	22.11	9.82	94	72646	65829	110450730
Bursitis	22.04	9.82	32	72708	129886	110386673
Wheezing	21.81	9.82	90	72650	255140	110261419
Deep vein thrombosis postoperative	21.78	9.82	6	72734	59285	110457274
Oedema peripheral	21.76	9.82	320	72420	328340	110188219
Therapeutic response decreased	21.57	9.82	19	72721	96480	110420079
Hypercholesterolaemia	21.39	9.82	17	72723	90820	110425739
Hospice care	21.14	9.82	33	72707	12440	110504119
Prolonged expiration	21.10	9.82	13	72727	1539	110515020
Musculoskeletal stiffness	20.73	9.82	104	72636	279718	110236841
Herpes zoster	20.64	9.82	132	72608	108247	110408312
Nausea	20.53	9.82	1001	71739	1234689	109281870
Blood potassium decreased	20.40	9.82	80	72660	54034	110462525
Hypervolaemia	20.19	9.82	75	72665	49385	110467174
Injection site erythema	20.01	9.82	118	72622	94058	110422501
Autoimmune disorder	19.99	9.82	9	72731	65474	110451085
Irritable bowel syndrome	19.52	9.82	50	72690	164165	110352394
Pulmonary fibrosis	19.50	9.82	23	72717	102019	110414540
Pneumonia aspiration	19.38	9.82	105	72635	81128	110435431
Pneumonia bacterial	19.37	9.82	49	72691	26212	110490347
Fluid retention	19.29	9.82	117	72623	94190	110422369
Eosinophilia	19.25	9.82	7	72733	57929	110458630
Adjustment disorder with depressed mood	19.08	9.82	3	72737	43880	110472679
Coma	19.06	9.82	30	72710	117839	110398720
Gastrointestinal haemorrhage	18.41	9.82	178	72562	165340	110351219
Product complaint	18.38	9.82	33	72707	13939	110502620
Drug eruption	18.37	9.82	77	72663	53582	110462977
Femoral neck fracture	18.25	9.82	31	72709	12536	110504023
Infection	17.98	9.82	152	72588	362048	110154511
Inflammation	17.88	9.82	66	72674	193172	110323387
Haemorrhage subcutaneous	17.70	9.82	20	72720	5519	110511040
Transfusion	17.22	9.82	46	72694	25426	110491133
Small intestinal obstruction	16.79	9.82	53	72687	32160	110484399
Cholestasis	16.59	9.82	11	72729	64507	110452052
Coeliac disease	16.57	9.82	4	72736	43183	110473376
Pelvic pain	16.49	9.82	34	72706	15908	110500651
Laryngeal pain	16.47	9.82	20	72720	5955	110510604
Pulmonary arterial hypertension	16.44	9.82	53	72687	32515	110484044
Hiccups	16.43	9.82	30	72710	12839	110503720
Suicide attempt	16.08	9.82	27	72713	103367	110413192
Hypopituitarism	16.03	9.82	17	72723	4373	110512186
Protein total decreased	15.99	9.82	27	72713	10863	110505696
Occult blood positive	15.95	9.82	22	72718	7423	110509136
Hip fracture	15.79	9.82	55	72685	35096	110481463
Dysgeusia	15.72	9.82	89	72651	69896	110446663
Pulmonary hypertension	15.71	9.82	75	72665	55145	110461414
X-ray abnormal	15.71	9.82	3	72737	38114	110478445
Ileus	15.51	9.82	50	72690	30679	110485880
Sideroblastic anaemia	15.46	9.82	7	72733	442	110516117
Blood bilirubin increased	15.38	9.82	94	72646	75878	110440681
Mental status changes	15.29	9.82	94	72646	76028	110440531
Osteoarthritis	15.22	9.82	65	72675	182558	110334001
Atrial fibrillation	14.96	9.82	223	72517	229419	110287140
Nasal congestion	14.77	9.82	113	72627	98169	110418390
Bone erosion	14.75	9.82	6	72734	46365	110470194
Cataract nuclear	14.73	9.82	10	72730	1396	110515163
Renal impairment	14.71	9.82	189	72551	188256	110328303
Colon cancer	14.63	9.82	33	72707	16410	110500149
Cardiac disorder	14.58	9.82	93	72647	76187	110440372
Injection site pain	14.55	9.82	180	72560	177742	110338817
Sudden hearing loss	14.51	9.82	12	72728	2257	110514302
Hepatitis	14.48	9.82	23	72717	90031	110426528
Cardiogenic shock	14.45	9.82	10	72730	57328	110459231
Blister	14.39	9.82	89	72651	227287	110289272
Onychomadesis	14.38	9.82	6	72734	45657	110470902
International normalised ratio increased	14.31	9.82	102	72638	86670	110429889
Viral infection	14.28	9.82	71	72669	53068	110463491
Foot deformity	14.28	9.82	7	72733	48473	110468086
Injection site haemorrhage	14.25	9.82	51	72689	32977	110483582
Ureterolithiasis	14.25	9.82	16	72724	4386	110512173
Bronchitis	14.22	9.82	162	72578	156870	110359689
Erythema multiforme	14.16	9.82	38	72702	21059	110495500
Brain natriuretic peptide increased	14.14	9.82	26	72714	11183	110505376
Cholangitis acute	14.11	9.82	11	72729	1902	110514657
Multiple organ dysfunction syndrome	13.91	9.82	52	72688	151658	110364901
Lactic acidosis	13.74	9.82	25	72715	92786	110423773
Back pain	13.68	9.82	330	72410	370666	110145893
Hypoalbuminaemia	13.60	9.82	46	72694	28928	110487631
Accidental exposure to product	13.59	9.82	8	72732	50000	110466559
Sciatica	13.58	9.82	25	72715	92374	110424185
Tremor	13.41	9.82	197	72543	202035	110314524
Eye swelling	13.39	9.82	50	72690	32998	110483561
Complication associated with device	13.32	9.82	36	72704	20037	110496522
Hypoxia	13.30	9.82	137	72603	129378	110387181
Spondylitic myelopathy	13.23	9.82	4	72736	79	110516480
Disseminated intravascular coagulation	13.18	9.82	58	72682	41228	110475331
Therapy partial responder	13.15	9.82	4	72736	37057	110479502
Fatigue	13.11	9.82	948	71792	1215010	109301549
Obstructive airways disorder	13.09	9.82	7	72733	46142	110470417
Blood albumin decreased	13.06	9.82	44	72696	27608	110488951
Pain	13.05	9.82	505	72235	954450	109562109
Sedation	13.00	9.82	16	72724	69667	110446892
Influenza like illness	12.92	9.82	101	72639	88311	110428248
C-reactive protein increased	12.92	9.82	87	72653	217832	110298727
Vaginal haemorrhage	12.83	9.82	41	72699	25033	110491526
Flushing	12.83	9.82	115	72625	104621	110411938
Finger deformity	12.82	9.82	3	72737	33089	110483470
Rib fracture	12.79	9.82	50	72690	33720	110482839
Respiration abnormal	12.69	9.82	23	72717	9786	110506773
Injection site induration	12.63	9.82	25	72715	11358	110505201
Blood glucose increased	12.60	9.82	138	72602	132358	110384201
Enterocolitis	12.59	9.82	34	72706	18915	110497644
Hypophagia	12.54	9.82	68	72672	52558	110464001
Visual acuity reduced	12.48	9.82	48	72692	32125	110484434
Drug reaction with eosinophilia and systemic symptoms	12.25	9.82	22	72718	82073	110434486
Onychomycosis	12.23	9.82	5	72735	38526	110478033
Gastric ulcer haemorrhage	12.22	9.82	23	72717	10071	110506488
Nephrogenic anaemia	12.10	9.82	15	72725	4562	110511997
Osteonecrosis of jaw	12.09	9.82	63	72677	47954	110468605
Breast cancer stage III	11.99	9.82	21	72719	79096	110437463
Live birth	11.90	9.82	17	72723	69467	110447092
Hypoproteinaemia	11.90	9.82	17	72723	5928	110510631
Disease progression	11.87	9.82	226	72514	243808	110272751
Rash pruritic	11.67	9.82	107	72633	97962	110418597
Hyperuricaemia	11.66	9.82	28	72712	14503	110502056
Concomitant disease aggravated	11.52	9.82	30	72710	16334	110500225
Heavy menstrual bleeding	11.52	9.82	30	72710	16335	110500224
Alanine aminotransferase increased	11.40	9.82	177	72563	183596	110332963
Decubitus ulcer	11.40	9.82	32	72708	18204	110498355
Influenza	11.32	9.82	165	72575	168936	110347623
Liver function test increased	11.28	9.82	26	72714	88522	110428037
Bulbospinal muscular atrophy congenital	11.24	9.82	3	72737	37	110516522
Impaired quality of life	11.09	9.82	3	72737	30014	110486545
Mucosal inflammation	10.87	9.82	30	72710	96111	110420448
Blood pressure systolic increased	10.87	9.82	24	72716	82967	110433592
Labelled drug-drug interaction medication error	10.70	9.82	3	72737	29299	110487260
Injection site mass	10.62	9.82	38	72702	24575	110491984
Impaired healing	10.47	9.82	81	72659	196636	110319923
Arthralgia	10.26	9.82	414	72326	779218	109737341
Wound infection	10.25	9.82	31	72709	96434	110420125
Urinary occult blood	10.24	9.82	3	72737	53	110516506
Angioedema	10.22	9.82	32	72708	98468	110418091
Headache	10.19	9.82	692	72048	881685	109634874
Intentional self-injury	10.15	9.82	6	72734	37423	110479136
Depression	10.15	9.82	277	72463	317058	110199501
Weight decreased	10.14	9.82	390	72350	467667	110048892
Lymphopenia	10.13	9.82	7	72733	40163	110476396
Blood pressure decreased	10.09	9.82	118	72622	114973	110401586
Confusional state	10.09	9.82	233	72507	468447	110048112
Blood potassium increased	10.08	9.82	46	72694	33203	110483356
Psoriatic arthropathy	10.02	9.82	82	72658	196679	110319880
Abdominal adhesions	9.92	9.82	13	72727	4177	110512382
Application site discolouration	9.91	9.82	7	72733	1042	110515517

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	B03BA05	BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS VITAMIN B12 AND FOLIC ACID Vitamin B12 (cyanocobalamin and analogues)
CHEBI has role	CHEBI:23357	cofactor
CHEBI has role	CHEBI:35705	immunosuppressive agent
CHEBI has role	CHEBI:75771	mouse metabolite
CHEBI has role	CHEBI:77746	human metabolite
CHEBI has role	CHEBI:35526	hypoglycemic agent
CHEBI has role	CHEBI:75835	anti-anaemic agent

Related Drugs by ATC class:

B03BA Vitamin B12 (cyanocobalamin and analogues) 3 drugs

cobamamidecyanocobalaminhydroxocobalamin

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Prevention of Vitamin B12 Deficiency	indication
Hypokalemia	contraindication	43339004
Gastrectomy	contraindication	53442002
Leber's optic atrophy	contraindication	58610003	DOID:705
Atrophic gastritis	contraindication	84568007	DOID:8929

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D03246	KEGG_DRUG
4024930	VUID
N0000179178	NUI
4024930	VANDF
CHEBI:28115	CHEBI
CHEMBL4297672	ChEMBL_ID
CHEMBL2359370	ChEMBL_ID
C019476	MESH_SUPPLEMENTAL_RECORD_UI
DB03614	DRUGBANK_ID
29421	RXNORM
210599	MMSL
295772	MMSL
29966	MMSL
338725	MMSL
361118	MMSL
60213	MMSL
NOCODE	MMSL
d05311	MMSL
007745	NDDF
259512006	SNOMEDCT_US
714678000	SNOMEDCT_US
C0065844	UMLSCUI
73415798	PUBCHEM_CID
3148	INN_ID
BR1SN1JS2W	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
healthy mamaBE WELL ROUNDED BE WELL ROUNDED	HUMAN PRESCRIPTION DRUG LABEL	17	58154-107	TABLET, FILM COATED	8 ug	ORAL	unapproved drug other	8 sections
Multitol-M	HUMAN PRESCRIPTION DRUG LABEL	17	59088-005	TABLET	8 ug	ORAL	unapproved drug other	11 sections
Finazol	HUMAN PRESCRIPTION DRUG LABEL	24	59088-008	TABLET	26 ug	ORAL	unapproved drug other	13 sections
Prenatol-M	HUMAN PRESCRIPTION DRUG LABEL	20	59088-009	TABLET	10 ug	ORAL	unapproved drug other	13 sections
Multivitamin	HUMAN PRESCRIPTION DRUG LABEL	11	59088-018	TABLET, CHEWABLE	4.50 ug	ORAL	unapproved drug other	11 sections
Boostervite	HUMAN PRESCRIPTION DRUG LABEL	16	59088-022	TABLET	100 ug	ORAL	unapproved drug other	15 sections
Davimet-M	HUMAN PRESCRIPTION DRUG LABEL	11	59088-158	TABLET, CHEWABLE	4.50 ug	ORAL	unapproved drug other	11 sections
Davimet with Iron	HUMAN PRESCRIPTION DRUG LABEL	12	59088-160	TABLET	4.50 ug	ORAL	unapproved drug other	13 sections
Diatrol	HUMAN PRESCRIPTION DRUG LABEL	17	59088-162	TABLET	8 ug	ORAL	unapproved drug other	11 sections
Davimet with Fluoride	HUMAN PRESCRIPTION DRUG LABEL	12	59088-170	TABLET, CHEWABLE	4.50 ug	ORAL	unapproved drug other	10 sections
Livita Adults	HUMAN PRESCRIPTION DRUG LABEL	17	59088-659	LIQUID	2.40 ug	ORAL	unapproved drug other	10 sections
Livita Children	HUMAN PRESCRIPTION DRUG LABEL	17	59088-660	LIQUID	0.80 ug	ORAL	unapproved drug other	10 sections
Vita-Rx Diabetic Vitamin	HUMAN PRESCRIPTION DRUG LABEL	14	69677-050	CAPSULE, GELATIN COATED	0.00 mg	ORAL	unapproved drug other	5 sections
B-Combo	HUMAN PRESCRIPTION DRUG LABEL	6	70104-110	INJECTION	1 mg	INTRAMUSCULAR	unapproved drug other	1 sections
Lipovite	HUMAN PRESCRIPTION DRUG LABEL	13	70104-128	INJECTION	1 mg	INTRAMUSCULAR	unapproved drug other	1 sections
MIC B12	HUMAN PRESCRIPTION DRUG LABEL	4	70104-806	INJECTION	1 mg	INTRAMUSCULAR	unapproved drug other	1 sections
Methylcobalamin	HUMAN PRESCRIPTION DRUG LABEL	1	70104-826	INJECTION	1 mg	INTRAMUSCULAR	unapproved drug other	1 sections
Zyrexal	HUMAN PRESCRIPTION DRUG LABEL	8	72380-915	TABLET	1 mg	ORAL	unapproved drug other	8 sections
Folinex	HUMAN PRESCRIPTION DRUG LABEL	4	72380-916	CAPSULE	1 mg	ORAL	unapproved drug other	8 sections
Cobalefol	HUMAN PRESCRIPTION DRUG LABEL	9	72835-550	CAPSULE	10 ug	ORAL	unapproved drug other	7 sections
Matervia	HUMAN PRESCRIPTION DRUG LABEL	9	72835-660	CAPSULE	1000 ug	ORAL	unapproved drug other	7 sections
Embriva	HUMAN PRESCRIPTION DRUG LABEL	9	85477-322	TABLET	1 mg	ORAL	unapproved drug other	8 sections
Vitavera	HUMAN PRESCRIPTION DRUG LABEL	11	85477-513	TABLET, CHEWABLE	4 ug	ORAL	unapproved drug other	13 sections
Virexa	HUMAN PRESCRIPTION DRUG LABEL	8	85477-606	TABLET	1 mg	ORAL	unapproved drug other	5 sections
Lumavex	HUMAN PRESCRIPTION DRUG LABEL	8	85477-610	CAPSULE	0.50 mg	ORAL	unapproved drug other	10 sections
Lunavira	HUMAN PRESCRIPTION DRUG LABEL	8	85477-623	CAPSULE	0.50 mg	ORAL	unapproved drug other	7 sections
Gestyra	HUMAN PRESCRIPTION DRUG LABEL	9	85477-922	TABLET	1000 ug	ORAL	unapproved drug other	8 sections