mecobalamin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4600 13422-55-4

Description:

MoleculeDescription

Synonyms:

  • mecobalamin
  • methycobal
  • methyl cobalamine
  • Methyl vitamin B12
  • methylcobalamin
  • methylcobaz
  • Molecular weight: 1344.40
  • Formula: C63H91CoN13O14P
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 488.71
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
1.50 mg O
0.20 mg P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 145.75 9.33 13 53654 326851 90247929
Hand deformity 143.05 9.33 8 53659 296354 90278426
Systemic lupus erythematosus 127.62 9.33 29 53638 361867 90212913
Treatment failure 125.50 9.33 16 53651 303912 90270868
Platelet count decreased 110.54 9.33 248 53419 136721 90438059
Contraindicated product administered 106.37 9.33 29 53638 320110 90254670
Synovitis 103.84 9.33 33 53634 329719 90245061
Product use in unapproved indication 100.08 9.33 37 53630 336199 90238581
Drug ineffective 97.54 9.33 456 53211 1383842 89190938
Diarrhoea 93.93 9.33 907 52760 938283 89636497
Helicobacter infection 91.11 9.33 13 53654 226837 90347943
Duodenal ulcer perforation 90.48 9.33 12 53655 221276 90353504
Rheumatoid factor positive 88.17 9.33 3 53664 171647 90403133
Maternal exposure during pregnancy 86.68 9.33 53 53614 360010 90214770
Off label use 86.09 9.33 349 53318 1101903 89472877
Product use issue 84.51 9.33 45 53622 329874 90244906
Drug intolerance 83.68 9.33 85 53582 447506 90127274
Pericarditis 81.61 9.33 29 53638 270122 90304658
Arthropathy 81.30 9.33 59 53608 366183 90208597
Fall 81.01 9.33 525 53142 481285 90093495
Glossodynia 77.95 9.33 47 53620 321732 90253048
Rheumatic fever 77.52 9.33 3 53664 153118 90421662
Therapeutic product effect decreased 73.85 9.33 36 53631 277535 90297245
Wound 72.35 9.33 45 53622 302935 90271845
Product dose omission issue 70.91 9.33 351 53316 291336 90283444
Toxicity to various agents 68.38 9.33 43 53624 287803 90286977
White blood cell count decreased 67.38 9.33 235 53432 166874 90407906
Drug hypersensitivity 66.98 9.33 107 53560 463502 90111278
Neutrophil count decreased 63.92 9.33 135 53532 71397 90503383
C-reactive protein abnormal 62.83 9.33 3 53664 127426 90447354
Intentional product use issue 62.62 9.33 25 53642 216867 90357913
Anti-cyclic citrullinated peptide antibody positive 60.89 9.33 32 53635 236401 90338379
Sleep disorder due to general medical condition, insomnia type 60.47 9.33 4 53663 128690 90446090
Unevaluable event 60.43 9.33 113 53554 54735 90520045
Ill-defined disorder 59.07 9.33 18 53649 184873 90389907
Muscle injury 58.64 9.33 16 53651 176638 90398142
Device expulsion 57.77 9.33 94 53573 40792 90533988
Infusion related reaction 57.57 9.33 99 53568 416681 90158099
Muscle spasms 56.92 9.33 297 53370 251586 90323194
Type 2 diabetes mellitus 56.15 9.33 25 53642 203219 90371561
Deep vein thrombosis 55.87 9.33 149 53518 91471 90483309
Discomfort 54.84 9.33 49 53618 274286 90300494
Dizziness 53.30 9.33 558 53109 588726 89986054
Plasma cell myeloma 51.20 9.33 89 53578 40739 90534041
Neuropathy peripheral 50.42 9.33 187 53480 136783 90437997
Dehydration 50.09 9.33 238 53429 194209 90380571
Lower respiratory tract infection 48.64 9.33 46 53621 250613 90324167
Fibromyalgia 46.03 9.33 33 53634 206236 90368544
Pneumonia 45.93 9.33 578 53089 637481 89937299
Full blood count decreased 44.33 9.33 70 53597 29619 90545161
Hypocholesterolaemia 44.17 9.33 34 53633 6415 90568365
Device dislocation 43.96 9.33 72 53595 31410 90543370
Anaemia 43.40 9.33 357 53310 352445 90222335
Liver injury 42.57 9.33 24 53643 170543 90404237
Alopecia 42.17 9.33 151 53516 494920 90079860
Hypersensitivity 41.91 9.33 134 53533 454543 90120237
Joint swelling 41.89 9.33 155 53512 503145 90071635
Feeling abnormal 41.84 9.33 203 53464 167032 90407748
Haemoglobin decreased 41.54 9.33 198 53469 161758 90413022
Therapy cessation 41.41 9.33 76 53591 36285 90538495
Hepatic function abnormal 39.78 9.33 86 53581 46202 90528578
Therapeutic product effect incomplete 39.50 9.33 34 53633 193862 90380918
Hepatic enzyme increased 39.38 9.33 98 53569 360638 90214142
Urinary tract infection 37.43 9.33 309 53358 305323 90269457
Gastrointestinal disorder 37.25 9.33 59 53608 256628 90318152
Prescribed overdose 36.06 9.33 7 53660 97618 90477162
Folliculitis 35.70 9.33 41 53626 204312 90370468
Hypercholesterolaemia 33.73 9.33 9 53658 100883 90473897
General physical health deterioration 33.17 9.33 104 53563 355011 90219769
Constipation 33.01 9.33 281 53386 280114 90294666
Swelling 32.95 9.33 132 53535 418926 90155854
Infection 31.78 9.33 109 53558 361985 90212795
Nausea 31.29 9.33 869 52798 1109447 89465333
Intentional overdose 30.20 9.33 9 53658 93825 90480955
Flatulence 30.14 9.33 72 53595 41295 90533485
Mobility decreased 29.85 9.33 65 53602 250669 90324111
Grip strength decreased 29.58 9.33 9 53658 92567 90482213
Asthenia 29.27 9.33 461 53206 533290 90041490
Facet joint syndrome 28.95 9.33 11 53656 98378 90476402
Rheumatoid arthritis 28.01 9.33 115 53552 362499 90212281
Irritable bowel syndrome 27.06 9.33 51 53616 207397 90367383
Condition aggravated 26.70 9.33 225 53442 595320 89979460
Aspartate aminotransferase increased 26.49 9.33 126 53541 102811 90471969
Blister 26.48 9.33 71 53596 254927 90319853
Heart sounds 26.09 9.33 13 53654 1131 90573649
Spinal compression fracture 25.78 9.33 38 53629 15140 90559640
Pulmonary embolism 25.32 9.33 148 53519 130672 90444108
Prolonged expiration 24.93 9.33 13 53654 1244 90573536
Back pain 24.77 9.33 292 53375 316883 90257897
Deep vein thrombosis postoperative 24.28 9.33 6 53661 70803 90503977
Pulmonary fibrosis 24.23 9.33 17 53650 107486 90467294
Injection site erythema 24.21 9.33 119 53548 98383 90476397
Hot flush 23.38 9.33 83 53584 59405 90515375
Adjustment disorder with depressed mood 23.37 9.33 3 53664 56750 90518030
Fatigue 23.28 9.33 868 52799 1153155 89421625
Asthma 23.25 9.33 70 53597 242090 90332690
Headache 22.78 9.33 670 52997 862076 89712704
Injection site mass 22.46 9.33 44 53623 22046 90552734
Psoriasis 22.33 9.33 157 53510 147597 90427183
Blood potassium decreased 21.77 9.33 70 53597 47657 90527123
Musculoskeletal stiffness 21.69 9.33 96 53571 296436 90278344
Confusional state 21.58 9.33 137 53530 386068 90188712
Injection site pain 21.44 9.33 176 53491 173523 90401257
Lip dry 21.42 9.33 17 53650 100938 90473842
Wheezing 21.33 9.33 71 53596 238009 90336771
Illness 21.22 9.33 11 53656 81958 90492822
Dyspnoea exertional 21.22 9.33 92 53575 72196 90502584
Nasal congestion 20.66 9.33 101 53566 83313 90491467
Pleural effusion 20.58 9.33 125 53542 111866 90462914
Tremor 20.44 9.33 158 53509 153015 90421765
Pelvic pain 19.94 9.33 34 53633 15323 90559457
Sleep disorder 19.91 9.33 56 53611 197974 90376806
Abdominal discomfort 19.76 9.33 184 53483 477144 90097636
Impaired healing 19.53 9.33 72 53595 234127 90340653
Injection site haemorrhage 19.26 9.33 48 53619 28270 90546510
Bone erosion 19.16 9.33 4 53663 53017 90521763
Atrial fibrillation 19.05 9.33 140 53527 133471 90441309
Multiple sclerosis relapse 18.89 9.33 71 53596 52234 90522546
Autoimmune disorder 18.85 9.33 11 53656 76733 90498047
Hypertension 18.66 9.33 177 53490 457355 90117425
Obesity 18.60 9.33 21 53646 105486 90469294
Bursitis 18.39 9.33 31 53636 131623 90443157
Brain natriuretic peptide increased 18.10 9.33 20 53647 5985 90568795
Pain 17.75 9.33 452 53215 995889 89578891
Product complaint 17.67 9.33 30 53637 13470 90561310
COVID-19 17.53 9.33 47 53620 168796 90405984
X-ray abnormal 17.32 9.33 3 53664 45421 90529359
Vaginal haemorrhage 17.21 9.33 49 53618 31222 90543558
Dysgeusia 17.07 9.33 69 53598 52491 90522289
Adverse event 17.01 9.33 27 53640 117391 90457389
C-reactive protein increased 17.00 9.33 53 53614 181336 90393444
Laboratory test abnormal 16.97 9.33 59 53608 41795 90532985
Cerebral infarction 16.96 9.33 44 53623 26552 90548228
Hypoxia 16.76 9.33 86 53581 72313 90502467
Decreased appetite 16.55 9.33 314 53353 376226 90198554
Blood bilirubin increased 16.53 9.33 60 53607 43410 90531370
Pollakiuria 16.52 9.33 50 53617 32955 90541825
Pulmonary arterial hypertension 16.37 9.33 43 53624 26144 90548636
Influenza like illness 16.12 9.33 92 53575 80519 90494261
Red blood cell count decreased 15.98 9.33 62 53605 46289 90528491
Upper respiratory tract inflammation 15.96 9.33 13 53654 2659 90572121
Hip arthroplasty 15.96 9.33 13 53654 76195 90498585
Intentional product misuse 15.61 9.33 18 53649 89586 90485194
Hip fracture 15.53 9.33 49 53618 33028 90541752
Eye swelling 15.16 9.33 45 53622 29341 90545439
Respiration abnormal 15.09 9.33 21 53646 7942 90566838
Occult blood positive 14.98 9.33 15 53652 4008 90570772
Cardiac failure congestive 14.98 9.33 105 53562 98589 90476191
Wound infection 14.91 9.33 25 53642 106377 90468403
Hypervolaemia 14.90 9.33 48 53619 32709 90542071
Chest discomfort 14.88 9.33 136 53531 138229 90436551
Drug interaction 14.45 9.33 100 53567 276353 90298427
Thrombosis 14.25 9.33 83 53584 73168 90501612
Skin discolouration 14.25 9.33 58 53609 44257 90530523
Sciatica 14.04 9.33 24 53643 101358 90473422
Oedema peripheral 13.81 9.33 222 53445 257693 90317087
Vision blurred 13.74 9.33 112 53555 110181 90464599
Tinea infection 13.68 9.33 9 53658 1327 90573453
Flushing 13.35 9.33 94 53573 88397 90486383
Pulmonary hypertension 13.16 9.33 55 53612 42468 90532312
Coeliac disease 13.10 9.33 5 53662 44605 90530175
Exposure during pregnancy 13.08 9.33 85 53582 238325 90336455
Depression 12.97 9.33 250 53417 300351 90274429
Inflammation 12.94 9.33 58 53609 178534 90396246
Overdose 12.81 9.33 49 53618 157660 90417120
Rash pruritic 12.79 9.33 88 53579 82126 90492654
Osteoarthritis 12.76 9.33 66 53601 195664 90379116
Tooth disorder 12.75 9.33 44 53623 31046 90543734
Administration site swelling 12.74 9.33 9 53658 1490 90573290
Myalgia 12.68 9.33 159 53508 174966 90399814
Plasma cell myeloma recurrent 12.60 9.33 14 53653 4214 90570566
Acne 12.27 9.33 41 53626 28466 90546314
Transfusion 12.27 9.33 30 53637 17458 90557322
Pelvic abscess 12.27 9.33 10 53657 2048 90572732
Suicide attempt 12.24 9.33 16 53651 75383 90499397
Onychomadesis 12.17 9.33 6 53661 45992 90528788
Cardiac disorder 12.09 9.33 66 53601 56806 90517974
Injection site induration 12.07 9.33 22 53645 10446 90564334
Cellulitis 12.06 9.33 94 53573 91243 90483537
Drug ineffective for unapproved indication 12.04 9.33 13 53654 66631 90508149
Interstitial lung disease 12.02 9.33 82 53585 76323 90498457
Erythema multiforme 11.98 9.33 24 53643 12222 90562558
Aortic aneurysm rupture 11.76 9.33 6 53661 549 90574231
Herpes zoster 11.73 9.33 96 53571 94548 90480232
Depressive symptom 11.64 9.33 15 53652 5270 90569510
Live birth 11.64 9.33 18 53649 79089 90495691
Foot deformity 11.50 9.33 11 53656 59640 90515140
Haemorrhage subcutaneous 11.45 9.33 12 53655 3384 90571396
Flank pain 11.45 9.33 31 53636 19191 90555589
Haematocrit decreased 11.34 9.33 52 53615 41780 90533000
Intestinal dilatation 11.26 9.33 10 53657 2300 90572480
Balance disorder 11.25 9.33 97 53570 96983 90477797
Body height decreased 11.19 9.33 23 53644 11926 90562854
Femoral neck fracture 11.16 9.33 21 53646 10212 90564568
Heavy menstrual bleeding 11.13 9.33 32 53635 20498 90554282
Endometriosis 11.13 9.33 16 53651 6232 90568548
Renal impairment 11.02 9.33 103 53564 105318 90469462
Sudden hearing loss 10.85 9.33 8 53659 1415 90573365
Breast cancer stage III 10.79 9.33 21 53646 84426 90490354
Therapy non-responder 10.76 9.33 43 53624 136661 90438119
Dry skin 10.73 9.33 89 53578 87984 90486796
Hospice care 10.69 9.33 20 53647 9684 90565096
Weight decreased 10.52 9.33 297 53370 379613 90195167
Blood cholesterol increased 10.50 9.33 76 53591 207936 90366844
Drug tolerance decreased 10.49 9.33 3 53664 32127 90542653
Cardiac pacemaker insertion 10.49 9.33 13 53654 4394 90570386
Laryngeal pain 10.45 9.33 13 53654 4409 90570371
Blood pressure decreased 10.40 9.33 78 53589 74817 90499963
Faeces discoloured 10.39 9.33 32 53635 21288 90553492
Visual acuity reduced 10.37 9.33 34 53633 23376 90551404
Uterine leiomyoma 10.28 9.33 21 53646 10843 90563937
Fluid retention 10.20 9.33 88 53579 88003 90486777
Pneumonia bacterial 10.12 9.33 23 53644 12767 90562013
International normalised ratio increased 10.12 9.33 55 53612 47261 90527519
Chills 10.06 9.33 121 53546 131860 90442920
Hypophagia 9.99 9.33 45 53622 35892 90538888
Gallbladder disorder 9.91 9.33 30 53637 19773 90555007
Dysstasia 9.88 9.33 35 53632 25017 90549763
Lymphocyte count decreased 9.82 9.33 44 53623 35006 90539774
Cough 9.81 9.33 287 53380 368675 90206105
Multiple allergies 9.60 9.33 25 53642 15121 90559659
Drug eruption 9.59 9.33 44 53623 35363 90539417
Knee arthroplasty 9.53 9.33 22 53645 83160 90491620
Infusion site nodule 9.50 9.33 8 53659 1715 90573065
Brain tumour operation 9.46 9.33 3 53664 78 90574702
Bone pain 9.44 9.33 66 53601 61917 90512863
Concomitant disease aggravated 9.44 9.33 21 53646 11497 90563283
Osteonecrosis of jaw 9.43 9.33 47 53620 39056 90535724
Foetal exposure during pregnancy 9.42 9.33 7 53660 42968 90531812
Injection site atrophy 9.41 9.33 6 53661 838 90573942
Pulmonary oedema 9.39 9.33 66 53601 62014 90512766
Gastrointestinal haemorrhage 9.34 9.33 88 53579 90160 90484620
Red blood cell sedimentation rate increased 9.34 9.33 22 53645 82573 90492207

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 92.33 11.16 230 33133 638105 41949867
Product use in unapproved indication 85.09 11.16 20 33343 184436 42403536
White blood cell count decreased 74.15 11.16 222 33141 110174 42477798
Platelet count decreased 73.48 11.16 257 33106 138324 42449648
Drug abuse 69.18 11.16 3 33360 104768 42483204
Plasma cell myeloma 64.93 11.16 126 33237 47452 42540520
Drug ineffective 62.56 11.16 268 33095 629929 41958043
Pneumonia 60.36 11.16 548 32815 421601 42166371
Toxicity to various agents 57.25 11.16 57 33306 229079 42358893
Completed suicide 49.62 11.16 8 33355 96457 42491515
Fall 43.37 11.16 323 33040 234197 42353775
Diarrhoea 43.25 11.16 550 32813 460299 42127673
Decreased appetite 38.56 11.16 271 33092 192866 42395106
Drug interaction 36.96 11.16 98 33265 266901 42321071
Full blood count decreased 35.08 11.16 60 33303 20500 42567472
General physical health deterioration 30.92 11.16 44 33319 151202 42436770
Constipation 27.43 11.16 219 33144 162072 42425900
Laboratory test abnormal 26.76 11.16 57 33306 22921 42565051
Treatment failure 26.54 11.16 8 33355 62616 42525356
Interstitial lung disease 25.31 11.16 125 33238 78337 42509635
Male sexual dysfunction 25.15 11.16 10 33353 382 42587590
Asthenia 24.91 11.16 332 33031 280461 42307511
Rash 24.80 11.16 328 33035 276626 42311346
Upper respiratory tract inflammation 23.53 11.16 16 33347 1880 42586092
Neuropathy peripheral 23.35 11.16 148 33215 101705 42486267
Fatigue 23.03 11.16 473 32890 435168 42152804
Dizziness 22.64 11.16 296 33067 248958 42339014
Drug ineffective for unapproved indication 21.26 11.16 5 33358 46158 42541814
Overdose 21.13 11.16 31 33332 105233 42482739
Coma 20.69 11.16 8 33355 53546 42534426
Haemoglobin decreased 19.83 11.16 174 33189 132297 42455675
Intentional product misuse 19.73 11.16 12 33351 61888 42526084
Intentional overdose 19.36 11.16 8 33355 51448 42536524
Neutrophil count decreased 19.02 11.16 99 33264 63316 42524656
Hepatic function abnormal 18.69 11.16 85 33278 51482 42536490
Cellulitis 18.37 11.16 96 33267 61489 42526483
Cataract nuclear 18.37 11.16 10 33353 787 42587185
Intentional product use issue 17.75 11.16 18 33345 71815 42516157
Muscular weakness 17.71 11.16 119 33244 83379 42504593
Multiple organ dysfunction syndrome 17.21 11.16 31 33332 97004 42490968
Product dose omission issue 16.45 11.16 189 33174 154176 42433796
Cholestasis 16.30 11.16 3 33360 32876 42555096
Hypopituitarism 16.09 11.16 15 33348 2776 42585196
Influenza 15.92 11.16 93 33270 62082 42525890
Tinea pedis 15.81 11.16 13 33350 2035 42585937
Viral infection 15.81 11.16 46 33317 22437 42565535
Spinal compression fracture 15.71 11.16 24 33339 7459 42580513
Sideroblastic anaemia 15.64 11.16 7 33356 360 42587612
Adverse drug reaction 15.32 11.16 64 33299 37370 42550602
Foetal exposure during pregnancy 15.31 11.16 9 33354 47302 42540670
Hiccups 15.11 11.16 31 33332 12140 42575832
Dehydration 14.84 11.16 173 33190 141594 42446378
Pleural effusion 14.73 11.16 128 33235 97038 42490934
Eosinophilia 14.31 11.16 4 33359 32895 42555077
COVID-19 14.22 11.16 45 33318 115903 42472069
Condition aggravated 13.80 11.16 134 33229 260620 42327352
Sinusitis 13.61 11.16 73 33290 47219 42540753
Hypoaesthesia 13.48 11.16 99 33264 71364 42516608
Red blood cell count decreased 13.44 11.16 56 33307 32659 42555313
Psoriasis 13.30 11.16 74 33289 48530 42539442
Cataract 13.05 11.16 53 33310 30551 42557421
Cardiogenic shock 12.69 11.16 6 33357 35634 42552338
Oedema peripheral 12.49 11.16 162 33201 135914 42452058
Muscle spasms 12.34 11.16 112 33251 85932 42502040
Leukopenia 12.27 11.16 25 33338 74721 42513251
Feeling abnormal 12.22 11.16 95 33268 69691 42518281
Contusion 12.21 11.16 65 33298 41920 42546052
Flatulence 11.90 11.16 45 33318 25107 42562865
Lower respiratory tract infection 11.78 11.16 9 33354 41197 42546775
Haematocrit decreased 11.52 11.16 56 33307 34852 42553120
Urinary occult blood 11.20 11.16 3 33360 31 42587941

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Platelet count decreased 184.28 9.82 443 72297 230000 110286559
Product use in unapproved indication 157.84 9.82 49 72691 447328 110069231
Drug ineffective 149.70 9.82 508 72232 1520032 108996527
Off label use 145.08 9.82 505 72235 1499680 109016879
Treatment failure 132.61 9.82 14 72726 277220 110239339
Completed suicide 124.71 9.82 9 72731 242372 110274187
Toxicity to various agents 121.14 9.82 84 72656 480471 110036088
Drug intolerance 115.06 9.82 62 72678 406450 110110109
Hand deformity 109.91 9.82 9 72731 218497 110298062
White blood cell count decreased 109.53 9.82 366 72374 229024 110287535
Plasma cell myeloma 100.53 9.82 162 72578 62774 110453785
Drug abuse 96.03 9.82 5 72735 177406 110339153
Fall 95.83 9.82 702 72038 602780 109913779
Pemphigus 94.90 9.82 14 72726 214556 110302003
Synovitis 91.40 9.82 33 72707 274059 110242500
Neutrophil count decreased 90.73 9.82 227 72513 120714 110395845
Pneumonia 90.08 9.82 926 71814 875788 109640771
Drug hypersensitivity 89.53 9.82 100 72640 453990 110062569
Systemic lupus erythematosus 89.37 9.82 28 72712 254310 110262249
Contraindicated product administered 80.91 9.82 31 72709 248236 110268323
Diarrhoea 78.31 9.82 1115 71625 1138390 109378169
Helicobacter infection 73.56 9.82 15 72725 181862 110334697
Rheumatoid factor positive 73.55 9.82 3 72737 131637 110384922
Duodenal ulcer perforation 73.25 9.82 14 72726 177686 110338873
Intentional product use issue 69.82 9.82 38 72702 247868 110268691
Dizziness 68.09 9.82 730 72010 697463 109819096
Product use issue 67.82 9.82 63 72677 311632 110204927
Hepatic function abnormal 67.38 9.82 168 72572 89127 110427432
Rheumatic fever 64.65 9.82 4 72736 122575 110393984
Arthropathy 63.88 9.82 57 72683 287465 110229094
Dehydration 63.31 9.82 356 72384 279155 110237404
Device expulsion 62.81 9.82 89 72651 30802 110485757
Maternal exposure during pregnancy 57.25 9.82 50 72690 254833 110261726
Haemoglobin decreased 57.12 9.82 318 72422 248409 110268150
Ill-defined disorder 55.57 9.82 17 72723 156836 110359723
Decreased appetite 54.74 9.82 515 72225 475331 110041228
Pericarditis 54.22 9.82 39 72701 219075 110297484
Sleep disorder due to general medical condition, insomnia type 54.10 9.82 4 72736 105639 110410920
Lower respiratory tract infection 53.03 9.82 49 72691 243057 110273502
Fibromyalgia 51.41 9.82 24 72716 170885 110345674
Therapeutic product effect decreased 51.25 9.82 51 72689 244265 110272294
Anti-cyclic citrullinated peptide antibody positive 49.64 9.82 29 72711 181955 110334604
Joint swelling 49.61 9.82 139 72601 442706 110073853
Interstitial lung disease 49.38 9.82 202 72538 139132 110377427
Muscle injury 48.56 9.82 16 72724 140791 110375768
Product dose omission issue 48.49 9.82 370 72370 321412 110195147
Drug interaction 47.59 9.82 169 72571 500014 110016545
Deep vein thrombosis 47.37 9.82 200 72540 139687 110376872
General physical health deterioration 47.26 9.82 134 72606 425161 110091398
Infusion related reaction 45.43 9.82 116 72624 381046 110135513
Anaemia 45.15 9.82 554 72186 546532 109970027
Glossodynia 44.69 9.82 48 72692 221956 110294603
Intentional overdose 44.07 9.82 16 72724 132485 110384074
Spinal compression fracture 43.47 9.82 57 72683 18335 110498224
Gastrointestinal disorder 42.67 9.82 58 72682 241894 110274665
Hypocholesterolaemia 41.14 9.82 34 72706 6387 110510172
Upper respiratory tract inflammation 40.91 9.82 29 72711 4342 110512217
Type 2 diabetes mellitus 40.73 9.82 34 72706 177198 110339361
Therapeutic product effect incomplete 38.12 9.82 55 72685 223750 110292809
Intentional product misuse 37.95 9.82 20 72720 132884 110383675
Therapy cessation 37.69 9.82 88 72652 44769 110471790
Asthenia 37.53 9.82 649 72091 688350 109828209
Full blood count decreased 37.46 9.82 72 72668 32027 110484532
Hypersensitivity 37.42 9.82 138 72602 403860 110112699
Device dislocation 36.86 9.82 71 72669 31633 110484926
Illness 34.88 9.82 6 72734 82165 110434394
Wound 34.87 9.82 63 72677 234374 110282185
Pleural effusion 34.83 9.82 218 72522 177491 110339068
Discomfort 34.41 9.82 55 72685 214652 110301907
Mobility decreased 34.25 9.82 65 72675 237357 110279202
Condition aggravated 34.10 9.82 314 72426 734522 109782037
Feeling abnormal 33.76 9.82 219 72521 180492 110336067
Facet joint syndrome 33.39 9.82 11 72729 96817 110419742
Cerebral infarction 32.45 9.82 91 72649 51747 110464812
Liver injury 31.99 9.82 31 72709 150382 110366177
Constipation 31.98 9.82 368 72372 357418 110159141
Muscle spasms 31.91 9.82 301 72439 277856 110238703
Rheumatoid arthritis 31.38 9.82 97 72643 299516 110217043
Alopecia 30.96 9.82 129 72611 364624 110151935
Overdose 30.34 9.82 68 72672 233726 110282833
Aspartate aminotransferase increased 29.98 9.82 194 72546 159742 110356817
Neuropathy peripheral 29.75 9.82 211 72529 179066 110337493
Unevaluable event 29.56 9.82 96 72644 59131 110457428
Hepatic enzyme increased 29.45 9.82 110 72630 320782 110195777
Male sexual dysfunction 28.79 9.82 10 72730 311 110516248
Drug ineffective for unapproved indication 28.59 9.82 16 72724 102822 110413737
Prescribed overdose 28.41 9.82 11 72729 87570 110428989
Cellulitis 28.16 9.82 160 72580 125856 110390703
Urinary tract infection 28.00 9.82 333 72407 325949 110190610
Multiple sclerosis relapse 27.43 9.82 84 72656 50156 110466403
Folliculitis 26.81 9.82 43 72697 167610 110348949
Grip strength decreased 26.12 9.82 10 72730 80164 110436395
COVID-19 25.90 9.82 79 72661 244981 110271578
Haematocrit decreased 25.13 9.82 98 72642 66019 110450540
Heart sounds 24.81 9.82 13 72727 1130 110515429
Asthma 24.15 9.82 84 72656 250207 110266352
Cardiac failure congestive 24.06 9.82 176 72564 150824 110365735
Swelling 24.05 9.82 134 72606 350907 110165652
Obesity 23.37 9.82 24 72716 113327 110403232
Lip dry 23.24 9.82 19 72721 100064 110416495
Dyspnoea exertional 23.17 9.82 132 72608 103928 110412631
Flatulence 22.92 9.82 81 72659 52068 110464491
Lymphocyte count decreased 22.70 9.82 86 72654 57157 110459402
Sleep disorder 22.47 9.82 62 72678 198582 110317977
Red blood cell count decreased 22.11 9.82 94 72646 65829 110450730
Bursitis 22.04 9.82 32 72708 129886 110386673
Wheezing 21.81 9.82 90 72650 255140 110261419
Deep vein thrombosis postoperative 21.78 9.82 6 72734 59285 110457274
Oedema peripheral 21.76 9.82 320 72420 328340 110188219
Therapeutic response decreased 21.57 9.82 19 72721 96480 110420079
Hypercholesterolaemia 21.39 9.82 17 72723 90820 110425739
Hospice care 21.14 9.82 33 72707 12440 110504119
Prolonged expiration 21.10 9.82 13 72727 1539 110515020
Musculoskeletal stiffness 20.73 9.82 104 72636 279718 110236841
Herpes zoster 20.64 9.82 132 72608 108247 110408312
Nausea 20.53 9.82 1001 71739 1234689 109281870
Blood potassium decreased 20.40 9.82 80 72660 54034 110462525
Hypervolaemia 20.19 9.82 75 72665 49385 110467174
Injection site erythema 20.01 9.82 118 72622 94058 110422501
Autoimmune disorder 19.99 9.82 9 72731 65474 110451085
Irritable bowel syndrome 19.52 9.82 50 72690 164165 110352394
Pulmonary fibrosis 19.50 9.82 23 72717 102019 110414540
Pneumonia aspiration 19.38 9.82 105 72635 81128 110435431
Pneumonia bacterial 19.37 9.82 49 72691 26212 110490347
Fluid retention 19.29 9.82 117 72623 94190 110422369
Eosinophilia 19.25 9.82 7 72733 57929 110458630
Adjustment disorder with depressed mood 19.08 9.82 3 72737 43880 110472679
Coma 19.06 9.82 30 72710 117839 110398720
Gastrointestinal haemorrhage 18.41 9.82 178 72562 165340 110351219
Product complaint 18.38 9.82 33 72707 13939 110502620
Drug eruption 18.37 9.82 77 72663 53582 110462977
Femoral neck fracture 18.25 9.82 31 72709 12536 110504023
Infection 17.98 9.82 152 72588 362048 110154511
Inflammation 17.88 9.82 66 72674 193172 110323387
Haemorrhage subcutaneous 17.70 9.82 20 72720 5519 110511040
Transfusion 17.22 9.82 46 72694 25426 110491133
Small intestinal obstruction 16.79 9.82 53 72687 32160 110484399
Cholestasis 16.59 9.82 11 72729 64507 110452052
Coeliac disease 16.57 9.82 4 72736 43183 110473376
Pelvic pain 16.49 9.82 34 72706 15908 110500651
Laryngeal pain 16.47 9.82 20 72720 5955 110510604
Pulmonary arterial hypertension 16.44 9.82 53 72687 32515 110484044
Hiccups 16.43 9.82 30 72710 12839 110503720
Suicide attempt 16.08 9.82 27 72713 103367 110413192
Hypopituitarism 16.03 9.82 17 72723 4373 110512186
Protein total decreased 15.99 9.82 27 72713 10863 110505696
Occult blood positive 15.95 9.82 22 72718 7423 110509136
Hip fracture 15.79 9.82 55 72685 35096 110481463
Dysgeusia 15.72 9.82 89 72651 69896 110446663
Pulmonary hypertension 15.71 9.82 75 72665 55145 110461414
X-ray abnormal 15.71 9.82 3 72737 38114 110478445
Ileus 15.51 9.82 50 72690 30679 110485880
Sideroblastic anaemia 15.46 9.82 7 72733 442 110516117
Blood bilirubin increased 15.38 9.82 94 72646 75878 110440681
Mental status changes 15.29 9.82 94 72646 76028 110440531
Osteoarthritis 15.22 9.82 65 72675 182558 110334001
Atrial fibrillation 14.96 9.82 223 72517 229419 110287140
Nasal congestion 14.77 9.82 113 72627 98169 110418390
Bone erosion 14.75 9.82 6 72734 46365 110470194
Cataract nuclear 14.73 9.82 10 72730 1396 110515163
Renal impairment 14.71 9.82 189 72551 188256 110328303
Colon cancer 14.63 9.82 33 72707 16410 110500149
Cardiac disorder 14.58 9.82 93 72647 76187 110440372
Injection site pain 14.55 9.82 180 72560 177742 110338817
Sudden hearing loss 14.51 9.82 12 72728 2257 110514302
Hepatitis 14.48 9.82 23 72717 90031 110426528
Cardiogenic shock 14.45 9.82 10 72730 57328 110459231
Blister 14.39 9.82 89 72651 227287 110289272
Onychomadesis 14.38 9.82 6 72734 45657 110470902
International normalised ratio increased 14.31 9.82 102 72638 86670 110429889
Viral infection 14.28 9.82 71 72669 53068 110463491
Foot deformity 14.28 9.82 7 72733 48473 110468086
Injection site haemorrhage 14.25 9.82 51 72689 32977 110483582
Ureterolithiasis 14.25 9.82 16 72724 4386 110512173
Bronchitis 14.22 9.82 162 72578 156870 110359689
Erythema multiforme 14.16 9.82 38 72702 21059 110495500
Brain natriuretic peptide increased 14.14 9.82 26 72714 11183 110505376
Cholangitis acute 14.11 9.82 11 72729 1902 110514657
Multiple organ dysfunction syndrome 13.91 9.82 52 72688 151658 110364901
Lactic acidosis 13.74 9.82 25 72715 92786 110423773
Back pain 13.68 9.82 330 72410 370666 110145893
Hypoalbuminaemia 13.60 9.82 46 72694 28928 110487631
Accidental exposure to product 13.59 9.82 8 72732 50000 110466559
Sciatica 13.58 9.82 25 72715 92374 110424185
Tremor 13.41 9.82 197 72543 202035 110314524
Eye swelling 13.39 9.82 50 72690 32998 110483561
Complication associated with device 13.32 9.82 36 72704 20037 110496522
Hypoxia 13.30 9.82 137 72603 129378 110387181
Spondylitic myelopathy 13.23 9.82 4 72736 79 110516480
Disseminated intravascular coagulation 13.18 9.82 58 72682 41228 110475331
Therapy partial responder 13.15 9.82 4 72736 37057 110479502
Fatigue 13.11 9.82 948 71792 1215010 109301549
Obstructive airways disorder 13.09 9.82 7 72733 46142 110470417
Blood albumin decreased 13.06 9.82 44 72696 27608 110488951
Pain 13.05 9.82 505 72235 954450 109562109
Sedation 13.00 9.82 16 72724 69667 110446892
Influenza like illness 12.92 9.82 101 72639 88311 110428248
C-reactive protein increased 12.92 9.82 87 72653 217832 110298727
Vaginal haemorrhage 12.83 9.82 41 72699 25033 110491526
Flushing 12.83 9.82 115 72625 104621 110411938
Finger deformity 12.82 9.82 3 72737 33089 110483470
Rib fracture 12.79 9.82 50 72690 33720 110482839
Respiration abnormal 12.69 9.82 23 72717 9786 110506773
Injection site induration 12.63 9.82 25 72715 11358 110505201
Blood glucose increased 12.60 9.82 138 72602 132358 110384201
Enterocolitis 12.59 9.82 34 72706 18915 110497644
Hypophagia 12.54 9.82 68 72672 52558 110464001
Visual acuity reduced 12.48 9.82 48 72692 32125 110484434
Drug reaction with eosinophilia and systemic symptoms 12.25 9.82 22 72718 82073 110434486
Onychomycosis 12.23 9.82 5 72735 38526 110478033
Gastric ulcer haemorrhage 12.22 9.82 23 72717 10071 110506488
Nephrogenic anaemia 12.10 9.82 15 72725 4562 110511997
Osteonecrosis of jaw 12.09 9.82 63 72677 47954 110468605
Breast cancer stage III 11.99 9.82 21 72719 79096 110437463
Live birth 11.90 9.82 17 72723 69467 110447092
Hypoproteinaemia 11.90 9.82 17 72723 5928 110510631
Disease progression 11.87 9.82 226 72514 243808 110272751
Rash pruritic 11.67 9.82 107 72633 97962 110418597
Hyperuricaemia 11.66 9.82 28 72712 14503 110502056
Concomitant disease aggravated 11.52 9.82 30 72710 16334 110500225
Heavy menstrual bleeding 11.52 9.82 30 72710 16335 110500224
Alanine aminotransferase increased 11.40 9.82 177 72563 183596 110332963
Decubitus ulcer 11.40 9.82 32 72708 18204 110498355
Influenza 11.32 9.82 165 72575 168936 110347623
Liver function test increased 11.28 9.82 26 72714 88522 110428037
Bulbospinal muscular atrophy congenital 11.24 9.82 3 72737 37 110516522
Impaired quality of life 11.09 9.82 3 72737 30014 110486545
Mucosal inflammation 10.87 9.82 30 72710 96111 110420448
Blood pressure systolic increased 10.87 9.82 24 72716 82967 110433592
Labelled drug-drug interaction medication error 10.70 9.82 3 72737 29299 110487260
Injection site mass 10.62 9.82 38 72702 24575 110491984
Impaired healing 10.47 9.82 81 72659 196636 110319923
Arthralgia 10.26 9.82 414 72326 779218 109737341
Wound infection 10.25 9.82 31 72709 96434 110420125
Urinary occult blood 10.24 9.82 3 72737 53 110516506
Angioedema 10.22 9.82 32 72708 98468 110418091
Headache 10.19 9.82 692 72048 881685 109634874
Intentional self-injury 10.15 9.82 6 72734 37423 110479136
Depression 10.15 9.82 277 72463 317058 110199501
Weight decreased 10.14 9.82 390 72350 467667 110048892
Lymphopenia 10.13 9.82 7 72733 40163 110476396
Blood pressure decreased 10.09 9.82 118 72622 114973 110401586
Confusional state 10.09 9.82 233 72507 468447 110048112
Blood potassium increased 10.08 9.82 46 72694 33203 110483356
Psoriatic arthropathy 10.02 9.82 82 72658 196679 110319880
Abdominal adhesions 9.92 9.82 13 72727 4177 110512382
Application site discolouration 9.91 9.82 7 72733 1042 110515517

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B03BA05 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
VITAMIN B12 AND FOLIC ACID
Vitamin B12 (cyanocobalamin and analogues)
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:75771 mouse metabolite
CHEBI has role CHEBI:77746 human metabolite
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:75835 anti-anaemic agent

Related Drugs by ATC class:

B03BA Vitamin B12 (cyanocobalamin and analogues) 3 drugs
cobamamidecyanocobalaminhydroxocobalamin

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Prevention of Vitamin B12 Deficiency indication
Hypokalemia contraindication 43339004
Gastrectomy contraindication 53442002
Leber's optic atrophy contraindication 58610003 DOID:705
Atrophic gastritis contraindication 84568007 DOID:8929




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D03246 KEGG_DRUG
4024930 VUID
N0000179178 NUI
4024930 VANDF
CHEBI:28115 CHEBI
CHEMBL4297672 ChEMBL_ID
CHEMBL2359370 ChEMBL_ID
C019476 MESH_SUPPLEMENTAL_RECORD_UI
DB03614 DRUGBANK_ID
29421 RXNORM
210599 MMSL
295772 MMSL
29966 MMSL
338725 MMSL
361118 MMSL
60213 MMSL
NOCODE MMSL
d05311 MMSL
007745 NDDF
259512006 SNOMEDCT_US
714678000 SNOMEDCT_US
C0065844 UMLSCUI
73415798 PUBCHEM_CID
3148 INN_ID
BR1SN1JS2W UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
healthy mamaBE WELL ROUNDED BE WELL ROUNDED HUMAN PRESCRIPTION DRUG LABEL 17 58154-107 TABLET, FILM COATED 8 ug ORAL unapproved drug other 8 sections
Multitol-M HUMAN PRESCRIPTION DRUG LABEL 17 59088-005 TABLET 8 ug ORAL unapproved drug other 11 sections
Finazol HUMAN PRESCRIPTION DRUG LABEL 24 59088-008 TABLET 26 ug ORAL unapproved drug other 13 sections
Prenatol-M HUMAN PRESCRIPTION DRUG LABEL 20 59088-009 TABLET 10 ug ORAL unapproved drug other 13 sections
Multivitamin HUMAN PRESCRIPTION DRUG LABEL 11 59088-018 TABLET, CHEWABLE 4.50 ug ORAL unapproved drug other 11 sections
Boostervite HUMAN PRESCRIPTION DRUG LABEL 16 59088-022 TABLET 100 ug ORAL unapproved drug other 15 sections
Davimet-M HUMAN PRESCRIPTION DRUG LABEL 11 59088-158 TABLET, CHEWABLE 4.50 ug ORAL unapproved drug other 11 sections
Davimet with Iron HUMAN PRESCRIPTION DRUG LABEL 12 59088-160 TABLET 4.50 ug ORAL unapproved drug other 13 sections
Diatrol HUMAN PRESCRIPTION DRUG LABEL 17 59088-162 TABLET 8 ug ORAL unapproved drug other 11 sections
Davimet with Fluoride HUMAN PRESCRIPTION DRUG LABEL 12 59088-170 TABLET, CHEWABLE 4.50 ug ORAL unapproved drug other 10 sections
Livita Adults HUMAN PRESCRIPTION DRUG LABEL 17 59088-659 LIQUID 2.40 ug ORAL unapproved drug other 10 sections
Livita Children HUMAN PRESCRIPTION DRUG LABEL 17 59088-660 LIQUID 0.80 ug ORAL unapproved drug other 10 sections
Vita-Rx Diabetic Vitamin HUMAN PRESCRIPTION DRUG LABEL 14 69677-050 CAPSULE, GELATIN COATED 0.00 mg ORAL unapproved drug other 5 sections
B-Combo HUMAN PRESCRIPTION DRUG LABEL 6 70104-110 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections
Lipovite HUMAN PRESCRIPTION DRUG LABEL 13 70104-128 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections
MIC B12 HUMAN PRESCRIPTION DRUG LABEL 4 70104-806 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections
Methylcobalamin HUMAN PRESCRIPTION DRUG LABEL 1 70104-826 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections
Zyrexal HUMAN PRESCRIPTION DRUG LABEL 8 72380-915 TABLET 1 mg ORAL unapproved drug other 8 sections
Folinex HUMAN PRESCRIPTION DRUG LABEL 4 72380-916 CAPSULE 1 mg ORAL unapproved drug other 8 sections
Cobalefol HUMAN PRESCRIPTION DRUG LABEL 9 72835-550 CAPSULE 10 ug ORAL unapproved drug other 7 sections
Matervia HUMAN PRESCRIPTION DRUG LABEL 9 72835-660 CAPSULE 1000 ug ORAL unapproved drug other 7 sections
Embriva HUMAN PRESCRIPTION DRUG LABEL 9 85477-322 TABLET 1 mg ORAL unapproved drug other 8 sections
Vitavera HUMAN PRESCRIPTION DRUG LABEL 11 85477-513 TABLET, CHEWABLE 4 ug ORAL unapproved drug other 13 sections
Virexa HUMAN PRESCRIPTION DRUG LABEL 8 85477-606 TABLET 1 mg ORAL unapproved drug other 5 sections
Lumavex HUMAN PRESCRIPTION DRUG LABEL 8 85477-610 CAPSULE 0.50 mg ORAL unapproved drug other 10 sections
Lunavira HUMAN PRESCRIPTION DRUG LABEL 8 85477-623 CAPSULE 0.50 mg ORAL unapproved drug other 7 sections
Gestyra HUMAN PRESCRIPTION DRUG LABEL 9 85477-922 TABLET 1000 ug ORAL unapproved drug other 8 sections