mecobalamin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4600 13422-55-4

Description:

MoleculeDescription

Synonyms:

  • mecobalamin
  • methycobal
  • methyl cobalamine
  • Methyl vitamin B12
  • methylcobalamin
  • methylcobaz
  • Molecular weight: 1344.40
  • Formula: C63H91CoN13O14P
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 488.71
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
1.50 mg O
0.20 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hepatic function abnormal 150.26 15.17 88 8506 34333 46643135
Platelet count decreased 103.73 15.17 109 8485 99915 46577553
Interstitial lung disease 84.79 15.17 74 8520 53875 46623593
Neutrophil count decreased 77.31 15.17 64 8530 43362 46634106
Altered state of consciousness 74.67 15.17 49 8545 23299 46654169
Drug eruption 61.55 15.17 42 8552 21287 46656181
Cerebral infarction 46.99 15.17 37 8557 23329 46654139
White blood cell count decreased 46.48 15.17 78 8516 112153 46565315
Decreased appetite 43.21 15.17 104 8490 193732 46483736
Upper respiratory tract inflammation 42.99 15.17 17 8577 2778 46674690
Erythema multiforme 42.79 15.17 25 8569 9679 46667789
Renal impairment 42.47 15.17 60 8534 74312 46603156
Drug ineffective 42.04 15.17 38 8556 677800 45999668
Sudden hearing loss 40.44 15.17 13 8581 1165 46676303
Haemorrhage subcutaneous 38.92 15.17 16 8578 2890 46674578
Disseminated intravascular coagulation 38.01 15.17 30 8564 18975 46658493
Cardiac failure 36.37 15.17 58 8536 79890 46597578
Osteonecrosis of jaw 34.70 15.17 37 8557 34365 46643103
Herpes zoster 33.32 15.17 51 8543 67821 46609647
Pyrexia 26.88 15.17 131 8463 348671 46328797
Blood lactate dehydrogenase increased 26.07 15.17 25 8569 20475 46656993
Femoral neck fracture 25.87 15.17 17 8577 8086 46669382
Oral mucosa erosion 25.44 15.17 9 8585 1081 46676387
Blood urea increased 25.09 15.17 27 8567 25325 46652143
Liver disorder 24.19 15.17 32 8562 37214 46640254
Anaemia 24.11 15.17 102 8492 255677 46421791
Pancytopenia 23.78 15.17 50 8544 85008 46592460
Pneumonia bacterial 23.36 15.17 15 8579 6864 46670604
Aspartate aminotransferase increased 22.86 15.17 47 8547 78653 46598815
Toxic encephalopathy 22.20 15.17 13 8581 5049 46672419
Lymphocyte stimulation test positive 21.82 15.17 7 8587 623 46676845
Hypotension 21.47 15.17 8 8586 232581 46444887
Inappropriate antidiuretic hormone secretion 21.43 15.17 19 8575 14083 46663385
Spinal compression fracture 20.85 15.17 18 8576 12885 46664583
Joint swelling 20.65 15.17 3 8591 166070 46511398
Enterocolitis 19.84 15.17 13 8581 6155 46671313
Osteomyelitis 18.99 15.17 22 8572 22361 46655107
Toxicity to various agents 18.37 15.17 8 8586 211758 46465710
Febrile neutropenia 18.13 15.17 48 8546 94579 46582889
Dyspnoea 18.02 15.17 43 8551 515505 46161963
Malignant neoplasm progression 17.95 15.17 38 8556 64888 46612580
Hypocalcaemia 17.37 15.17 23 8571 26762 46650706
Completed suicide 17.32 15.17 3 8591 145917 46531551
Pneumonia 17.06 15.17 123 8471 376197 46301271
Pain 16.49 15.17 40 8554 476908 46200560
Blood pressure decreased 16.43 15.17 34 8560 57125 46620343
Hypoglycaemia 16.42 15.17 33 8561 54316 46623152
Lacrimation decreased 16.12 15.17 5 8589 399 46677069
Blood cholinesterase decreased 15.96 15.17 4 8590 145 46677323
Stomatitis 15.55 15.17 37 8557 68260 46609208

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Interstitial lung disease 161.91 16.20 131 7787 60066 29884494
Hepatic function abnormal 95.49 16.20 83 7835 41862 29902698
Platelet count decreased 93.45 16.20 127 7791 106002 29838558
Renal impairment 64.01 16.20 94 7824 84090 29860470
Cerebral infarction 61.61 16.20 53 7865 26320 29918240
White blood cell count decreased 54.32 16.20 87 7831 83860 29860700
Disseminated intravascular coagulation 52.68 16.20 45 7873 22126 29922434
Altered state of consciousness 52.66 16.20 43 7875 19876 29924684
Liver disorder 52.37 16.20 51 7867 29671 29914889
Neutrophil count decreased 48.63 16.20 58 7860 42396 29902164
Lymphocyte count decreased 39.90 16.20 36 7882 19019 29925541
Upper respiratory tract inflammation 37.00 16.20 15 7903 1816 29942744
Drug eruption 36.47 16.20 33 7885 17493 29927067
Fatigue 32.01 16.20 23 7895 320650 29623910
Dyslalia 28.98 16.20 9 7909 499 29944061
Enterocolitis 27.91 16.20 19 7899 6668 29937892
Toxicity to various agents 26.63 16.20 7 7911 177176 29767384
Drug ineffective 24.09 16.20 33 7885 340354 29604206
Decreased appetite 22.79 16.20 89 7829 149821 29794739
Hypopituitarism 22.05 16.20 10 7908 1592 29942968
Colorectal cancer 21.05 16.20 10 7908 1769 29942791
Inappropriate antidiuretic hormone secretion 20.85 16.20 20 7898 11402 29933158
C-reactive protein increased 20.19 16.20 39 7879 43434 29901126
Gastric ulcer haemorrhage 19.60 16.20 14 7904 5300 29939260
Herpes zoster 19.27 16.20 31 7887 29912 29914648
Paronychia 18.69 16.20 11 7907 3000 29941560
Blood lactate dehydrogenase increased 18.57 16.20 25 7893 20576 29923984
Febrile neutropenia 17.56 16.20 65 7853 106628 29837932
Hyperuricaemia 17.53 16.20 15 7903 7379 29937181
Pneumonia 17.44 16.20 149 7769 334157 29610403
Pyrexia 17.38 16.20 135 7783 294354 29650206
Male sexual dysfunction 16.88 16.20 5 7913 236 29944324
Erythema multiforme 16.54 16.20 15 7903 7970 29936590

Pharmacologic Action:

SourceCodeDescription
ATC B03BA05 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
VITAMIN B12 AND FOLIC ACID
Vitamin B12 (cyanocobalamin and analogues)
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:75771 mus musculus metabolite
CHEBI has role CHEBI:77746 h. sapiens metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Prevention of Vitamin B12 Deficiency indication
Hypokalemia contraindication 43339004
Gastrectomy contraindication 53442002
Leber's optic atrophy contraindication 58610003 DOID:705
Atrophic gastritis contraindication 84568007 DOID:8929

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D03246 KEGG_DRUG
4024930 VUID
N0000179178 NUI
4024930 VANDF
C0065844 UMLSCUI
CHEBI:28115 CHEBI
CHEMBL2359370 ChEMBL_ID
CHEMBL4297672 ChEMBL_ID
CHEMBL2448537 ChEMBL_ID
DB03614 DRUGBANK_ID
C019476 MESH_SUPPLEMENTAL_RECORD_UI
3148 INN_ID
BR1SN1JS2W UNII
6474318 PUBCHEM_CID
29421 RXNORM
295772 MMSL
29966 MMSL
338725 MMSL
60213 MMSL
NOCODE MMSL
d05311 MMSL
007745 NDDF
259512006 SNOMEDCT_US
714678000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Organdrainex HUMAN OTC DRUG LABEL 13 44911-0457 LIQUID 3 [hp_X] ORAL unapproved drug other 9 sections
healthy mamaBE WELL ROUNDED BE WELL ROUNDED HUMAN PRESCRIPTION DRUG LABEL 17 58154-107 TABLET, FILM COATED 8 ug ORAL unapproved drug other 8 sections
Vita-Rx Diabetic Vitamin HUMAN PRESCRIPTION DRUG LABEL 14 65121-301 CAPSULE, GELATIN COATED 0.00 mg ORAL unapproved drug other 5 sections
Methaver HUMAN PRESCRIPTION DRUG LABEL 5 69336-353 CAPSULE 2 mg ORAL unapproved drug other 13 sections
Vita-Rx Diabetic Vitamin HUMAN PRESCRIPTION DRUG LABEL 14 69677-050 CAPSULE, GELATIN COATED 0.00 mg ORAL unapproved drug other 5 sections
B-Combo HUMAN PRESCRIPTION DRUG LABEL 6 70104-110 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections
Lipovite HUMAN PRESCRIPTION DRUG LABEL 13 70104-128 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections
MIC B12 HUMAN PRESCRIPTION DRUG LABEL 4 70104-806 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections
Methylcobalamin HUMAN PRESCRIPTION DRUG LABEL 1 70104-826 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections
Zyrexal HUMAN PRESCRIPTION DRUG LABEL 8 72380-915 TABLET 1 mg ORAL unapproved drug other 8 sections
Folinex HUMAN PRESCRIPTION DRUG LABEL 4 72380-916 CAPSULE 1 mg ORAL unapproved drug other 8 sections