Stem definition | Drug id | CAS RN |
---|---|---|
4600 | 13422-55-4 |
Molecule | Description |
---|---|
Synonyms:
|
|
Dose | Unit | Route |
---|---|---|
1.50 | mg | O |
0.20 | mg | P |
None
Date | Agency | Company | Orphan |
---|---|---|---|
None | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hepatic function abnormal | 150.26 | 15.17 | 88 | 8506 | 34333 | 46643135 |
Platelet count decreased | 103.73 | 15.17 | 109 | 8485 | 99915 | 46577553 |
Interstitial lung disease | 84.79 | 15.17 | 74 | 8520 | 53875 | 46623593 |
Neutrophil count decreased | 77.31 | 15.17 | 64 | 8530 | 43362 | 46634106 |
Altered state of consciousness | 74.67 | 15.17 | 49 | 8545 | 23299 | 46654169 |
Drug eruption | 61.55 | 15.17 | 42 | 8552 | 21287 | 46656181 |
Cerebral infarction | 46.99 | 15.17 | 37 | 8557 | 23329 | 46654139 |
White blood cell count decreased | 46.48 | 15.17 | 78 | 8516 | 112153 | 46565315 |
Decreased appetite | 43.21 | 15.17 | 104 | 8490 | 193732 | 46483736 |
Upper respiratory tract inflammation | 42.99 | 15.17 | 17 | 8577 | 2778 | 46674690 |
Erythema multiforme | 42.79 | 15.17 | 25 | 8569 | 9679 | 46667789 |
Renal impairment | 42.47 | 15.17 | 60 | 8534 | 74312 | 46603156 |
Drug ineffective | 42.04 | 15.17 | 38 | 8556 | 677800 | 45999668 |
Sudden hearing loss | 40.44 | 15.17 | 13 | 8581 | 1165 | 46676303 |
Haemorrhage subcutaneous | 38.92 | 15.17 | 16 | 8578 | 2890 | 46674578 |
Disseminated intravascular coagulation | 38.01 | 15.17 | 30 | 8564 | 18975 | 46658493 |
Cardiac failure | 36.37 | 15.17 | 58 | 8536 | 79890 | 46597578 |
Osteonecrosis of jaw | 34.70 | 15.17 | 37 | 8557 | 34365 | 46643103 |
Herpes zoster | 33.32 | 15.17 | 51 | 8543 | 67821 | 46609647 |
Pyrexia | 26.88 | 15.17 | 131 | 8463 | 348671 | 46328797 |
Blood lactate dehydrogenase increased | 26.07 | 15.17 | 25 | 8569 | 20475 | 46656993 |
Femoral neck fracture | 25.87 | 15.17 | 17 | 8577 | 8086 | 46669382 |
Oral mucosa erosion | 25.44 | 15.17 | 9 | 8585 | 1081 | 46676387 |
Blood urea increased | 25.09 | 15.17 | 27 | 8567 | 25325 | 46652143 |
Liver disorder | 24.19 | 15.17 | 32 | 8562 | 37214 | 46640254 |
Anaemia | 24.11 | 15.17 | 102 | 8492 | 255677 | 46421791 |
Pancytopenia | 23.78 | 15.17 | 50 | 8544 | 85008 | 46592460 |
Pneumonia bacterial | 23.36 | 15.17 | 15 | 8579 | 6864 | 46670604 |
Aspartate aminotransferase increased | 22.86 | 15.17 | 47 | 8547 | 78653 | 46598815 |
Toxic encephalopathy | 22.20 | 15.17 | 13 | 8581 | 5049 | 46672419 |
Lymphocyte stimulation test positive | 21.82 | 15.17 | 7 | 8587 | 623 | 46676845 |
Hypotension | 21.47 | 15.17 | 8 | 8586 | 232581 | 46444887 |
Inappropriate antidiuretic hormone secretion | 21.43 | 15.17 | 19 | 8575 | 14083 | 46663385 |
Spinal compression fracture | 20.85 | 15.17 | 18 | 8576 | 12885 | 46664583 |
Joint swelling | 20.65 | 15.17 | 3 | 8591 | 166070 | 46511398 |
Enterocolitis | 19.84 | 15.17 | 13 | 8581 | 6155 | 46671313 |
Osteomyelitis | 18.99 | 15.17 | 22 | 8572 | 22361 | 46655107 |
Toxicity to various agents | 18.37 | 15.17 | 8 | 8586 | 211758 | 46465710 |
Febrile neutropenia | 18.13 | 15.17 | 48 | 8546 | 94579 | 46582889 |
Dyspnoea | 18.02 | 15.17 | 43 | 8551 | 515505 | 46161963 |
Malignant neoplasm progression | 17.95 | 15.17 | 38 | 8556 | 64888 | 46612580 |
Hypocalcaemia | 17.37 | 15.17 | 23 | 8571 | 26762 | 46650706 |
Completed suicide | 17.32 | 15.17 | 3 | 8591 | 145917 | 46531551 |
Pneumonia | 17.06 | 15.17 | 123 | 8471 | 376197 | 46301271 |
Pain | 16.49 | 15.17 | 40 | 8554 | 476908 | 46200560 |
Blood pressure decreased | 16.43 | 15.17 | 34 | 8560 | 57125 | 46620343 |
Hypoglycaemia | 16.42 | 15.17 | 33 | 8561 | 54316 | 46623152 |
Lacrimation decreased | 16.12 | 15.17 | 5 | 8589 | 399 | 46677069 |
Blood cholinesterase decreased | 15.96 | 15.17 | 4 | 8590 | 145 | 46677323 |
Stomatitis | 15.55 | 15.17 | 37 | 8557 | 68260 | 46609208 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Interstitial lung disease | 161.91 | 16.20 | 131 | 7787 | 60066 | 29884494 |
Hepatic function abnormal | 95.49 | 16.20 | 83 | 7835 | 41862 | 29902698 |
Platelet count decreased | 93.45 | 16.20 | 127 | 7791 | 106002 | 29838558 |
Renal impairment | 64.01 | 16.20 | 94 | 7824 | 84090 | 29860470 |
Cerebral infarction | 61.61 | 16.20 | 53 | 7865 | 26320 | 29918240 |
White blood cell count decreased | 54.32 | 16.20 | 87 | 7831 | 83860 | 29860700 |
Disseminated intravascular coagulation | 52.68 | 16.20 | 45 | 7873 | 22126 | 29922434 |
Altered state of consciousness | 52.66 | 16.20 | 43 | 7875 | 19876 | 29924684 |
Liver disorder | 52.37 | 16.20 | 51 | 7867 | 29671 | 29914889 |
Neutrophil count decreased | 48.63 | 16.20 | 58 | 7860 | 42396 | 29902164 |
Lymphocyte count decreased | 39.90 | 16.20 | 36 | 7882 | 19019 | 29925541 |
Upper respiratory tract inflammation | 37.00 | 16.20 | 15 | 7903 | 1816 | 29942744 |
Drug eruption | 36.47 | 16.20 | 33 | 7885 | 17493 | 29927067 |
Fatigue | 32.01 | 16.20 | 23 | 7895 | 320650 | 29623910 |
Dyslalia | 28.98 | 16.20 | 9 | 7909 | 499 | 29944061 |
Enterocolitis | 27.91 | 16.20 | 19 | 7899 | 6668 | 29937892 |
Toxicity to various agents | 26.63 | 16.20 | 7 | 7911 | 177176 | 29767384 |
Drug ineffective | 24.09 | 16.20 | 33 | 7885 | 340354 | 29604206 |
Decreased appetite | 22.79 | 16.20 | 89 | 7829 | 149821 | 29794739 |
Hypopituitarism | 22.05 | 16.20 | 10 | 7908 | 1592 | 29942968 |
Colorectal cancer | 21.05 | 16.20 | 10 | 7908 | 1769 | 29942791 |
Inappropriate antidiuretic hormone secretion | 20.85 | 16.20 | 20 | 7898 | 11402 | 29933158 |
C-reactive protein increased | 20.19 | 16.20 | 39 | 7879 | 43434 | 29901126 |
Gastric ulcer haemorrhage | 19.60 | 16.20 | 14 | 7904 | 5300 | 29939260 |
Herpes zoster | 19.27 | 16.20 | 31 | 7887 | 29912 | 29914648 |
Paronychia | 18.69 | 16.20 | 11 | 7907 | 3000 | 29941560 |
Blood lactate dehydrogenase increased | 18.57 | 16.20 | 25 | 7893 | 20576 | 29923984 |
Febrile neutropenia | 17.56 | 16.20 | 65 | 7853 | 106628 | 29837932 |
Hyperuricaemia | 17.53 | 16.20 | 15 | 7903 | 7379 | 29937181 |
Pneumonia | 17.44 | 16.20 | 149 | 7769 | 334157 | 29610403 |
Pyrexia | 17.38 | 16.20 | 135 | 7783 | 294354 | 29650206 |
Male sexual dysfunction | 16.88 | 16.20 | 5 | 7913 | 236 | 29944324 |
Erythema multiforme | 16.54 | 16.20 | 15 | 7903 | 7970 | 29936590 |
Source | Code | Description |
---|---|---|
ATC | B03BA05 | BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS VITAMIN B12 AND FOLIC ACID Vitamin B12 (cyanocobalamin and analogues) |
CHEBI has role | CHEBI:23357 | cofactor |
CHEBI has role | CHEBI:75771 | mus musculus metabolite |
CHEBI has role | CHEBI:77746 | h. sapiens metabolites |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Prevention of Vitamin B12 Deficiency | indication | ||
Hypokalemia | contraindication | 43339004 | |
Gastrectomy | contraindication | 53442002 | |
Leber's optic atrophy | contraindication | 58610003 | DOID:705 |
Atrophic gastritis | contraindication | 84568007 | DOID:8929 |
None
None
None
None
ID | Source |
---|---|
D03246 | KEGG_DRUG |
4024930 | VUID |
N0000179178 | NUI |
4024930 | VANDF |
C0065844 | UMLSCUI |
CHEBI:28115 | CHEBI |
CHEMBL2359370 | ChEMBL_ID |
CHEMBL4297672 | ChEMBL_ID |
CHEMBL2448537 | ChEMBL_ID |
DB03614 | DRUGBANK_ID |
C019476 | MESH_SUPPLEMENTAL_RECORD_UI |
3148 | INN_ID |
BR1SN1JS2W | UNII |
6474318 | PUBCHEM_CID |
29421 | RXNORM |
295772 | MMSL |
29966 | MMSL |
338725 | MMSL |
60213 | MMSL |
NOCODE | MMSL |
d05311 | MMSL |
007745 | NDDF |
259512006 | SNOMEDCT_US |
714678000 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Organdrainex | HUMAN OTC DRUG LABEL | 13 | 44911-0457 | LIQUID | 3 [hp_X] | ORAL | unapproved drug other | 9 sections |
healthy mamaBE WELL ROUNDED BE WELL ROUNDED | HUMAN PRESCRIPTION DRUG LABEL | 17 | 58154-107 | TABLET, FILM COATED | 8 ug | ORAL | unapproved drug other | 8 sections |
Vita-Rx Diabetic Vitamin | HUMAN PRESCRIPTION DRUG LABEL | 14 | 65121-301 | CAPSULE, GELATIN COATED | 0.00 mg | ORAL | unapproved drug other | 5 sections |
Methaver | HUMAN PRESCRIPTION DRUG LABEL | 5 | 69336-353 | CAPSULE | 2 mg | ORAL | unapproved drug other | 13 sections |
Vita-Rx Diabetic Vitamin | HUMAN PRESCRIPTION DRUG LABEL | 14 | 69677-050 | CAPSULE, GELATIN COATED | 0.00 mg | ORAL | unapproved drug other | 5 sections |
B-Combo | HUMAN PRESCRIPTION DRUG LABEL | 6 | 70104-110 | INJECTION | 1 mg | INTRAMUSCULAR | unapproved drug other | 1 sections |
Lipovite | HUMAN PRESCRIPTION DRUG LABEL | 13 | 70104-128 | INJECTION | 1 mg | INTRAMUSCULAR | unapproved drug other | 1 sections |
MIC B12 | HUMAN PRESCRIPTION DRUG LABEL | 4 | 70104-806 | INJECTION | 1 mg | INTRAMUSCULAR | unapproved drug other | 1 sections |
Methylcobalamin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70104-826 | INJECTION | 1 mg | INTRAMUSCULAR | unapproved drug other | 1 sections |
Zyrexal | HUMAN PRESCRIPTION DRUG LABEL | 8 | 72380-915 | TABLET | 1 mg | ORAL | unapproved drug other | 8 sections |
Folinex | HUMAN PRESCRIPTION DRUG LABEL | 4 | 72380-916 | CAPSULE | 1 mg | ORAL | unapproved drug other | 8 sections |