folic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1231 59-30-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • folic acid
  • acifolic
  • aspol
  • cytofol
  • folacid
  • pteroylglutamic acid
  • folate sodium
A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (POACEAE). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia.
  • Molecular weight: 441.40
  • Formula: C19H19N7O6
  • CLOGP: -1.43
  • LIPINSKI: 2
  • HAC: 13
  • HDO: 6
  • TPSA: 207.93
  • ALOGS: -3.74
  • ROTB: 9
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.40 mg O
10 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.00 mg/mL Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 11.43 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 75 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 9.70 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 52 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.50 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.60 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ALK,AURKA,AURKC,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,ERBB2,FLT3,GRK2,GRK3,GSK3B,IKBKB,ITK,JAK1,JAK2,KIT,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MTOR,NTRK1,NTRK2,PDK1,PDK2,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKCD,PRKDC,SGK1,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2 62
kinase-selectivity-class ACVR2B,AXL,BRAF,CDK9,EIF2AK3,GRK2,GRK3,MAP2K6,MAPK7,PDK1,PIK3CD,STK33,TEK,TTK 14
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Aug. 13, 1946 FDA LEDERLE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1587.23 9.90 6550 821761 320314 89479822
Systemic lupus erythematosus 1556.91 9.90 6991 821320 354905 89445231
Glossodynia 1349.79 9.90 6171 822140 315608 89484528
Hand deformity 1123.29 9.90 5520 822791 290842 89509294
Arthropathy 1066.09 9.90 6346 821965 359896 89440240
Completed suicide 1027.74 9.90 78 828233 144980 89655156
Alopecia 938.60 9.90 7726 820585 487345 89312791
Abdominal discomfort 931.25 9.90 7498 820813 469830 89330306
Wound 896.10 9.90 5273 823038 297707 89502429
Toxicity to various agents 884.07 9.90 797 827514 287049 89513087
Maternal exposure during pregnancy 877.96 9.90 5965 822346 354098 89446038
Synovitis 788.91 9.90 5438 822873 324314 89475822
Anti-cyclic citrullinated peptide antibody positive 737.96 9.90 4175 824136 232258 89567878
Swelling 733.96 9.90 6427 821884 412631 89387505
Pericarditis 728.39 9.90 4591 823720 265560 89534576
Discomfort 653.40 9.90 4520 823791 269815 89530321
Contraindicated product administered 629.89 9.90 5041 823270 315098 89485038
Death 629.27 9.90 2106 826205 454445 89345691
Infusion related reaction 596.09 9.90 6124 822187 410656 89389480
Joint swelling 596.01 9.90 7124 821187 496176 89303960
Duodenal ulcer perforation 584.70 9.90 3742 824569 217546 89582590
Helicobacter infection 547.29 9.90 3750 824561 223100 89577036
Intentional overdose 536.65 9.90 103 828208 93731 89706405
Rheumatoid arthritis 491.31 9.90 5271 823040 357343 89442793
Pain 475.29 9.90 12183 816128 984158 88815978
Febrile neutropenia 442.51 9.90 476 827835 157873 89642263
Rheumatoid factor positive 437.54 9.90 2877 825434 168773 89631363
Drug interaction 423.88 9.90 1214 827097 275239 89524897
Drug abuse 405.25 9.90 124 828187 82223 89717913
Psoriatic arthropathy 390.15 9.90 3485 824826 224850 89575286
Disease progression 373.34 9.90 532 827779 156083 89644053
Hepatic enzyme increased 371.73 9.90 4978 823333 355758 89444378
Suicide attempt 361.32 9.90 119 828192 75280 89724856
Malignant neoplasm progression 361.17 9.90 269 828042 106601 89693535
Therapeutic product effect decreased 332.19 9.90 3939 824372 273632 89526504
Depressed level of consciousness 324.79 9.90 129 828182 72655 89727481
Musculoskeletal stiffness 322.90 9.90 4134 824177 292398 89507738
Impaired healing 311.99 9.90 3394 824917 230805 89569331
Product use issue 305.17 9.90 4467 823844 325452 89474684
Arthralgia 300.88 9.90 9272 819039 769250 89030886
Exposure during pregnancy 293.95 9.90 3403 824908 235007 89565129
Folliculitis 282.15 9.90 2983 825328 201370 89598766
Cardiac arrest 280.46 9.90 327 827984 104608 89695528
Overdose 277.32 9.90 646 827665 157063 89643073
Neutropenia 270.85 9.90 1096 827215 223808 89576328
Rheumatic fever 270.15 9.90 2354 825957 150767 89649369
Constipation 267.03 9.90 1487 826824 278908 89521228
Acute kidney injury 250.66 9.90 1805 826506 318582 89481554
Electrocardiogram QT prolonged 250.50 9.90 178 828133 72278 89727858
Hyperhidrosis 249.68 9.90 546 827765 135759 89664377
Blister 247.77 9.90 3483 824828 251515 89548621
Muscle injury 236.05 9.90 2562 825749 174092 89626044
Nausea 229.05 9.90 8081 820230 1102235 88697901
Sedation 227.35 9.90 78 828233 48093 89752043
Irritable bowel syndrome 226.03 9.90 2893 825418 204555 89595581
Drug intolerance 223.63 9.90 5512 822799 442079 89358057
Sleep disorder due to general medical condition, insomnia type 214.39 9.90 1954 826357 126740 89673396
Swollen joint count increased 212.72 9.90 1741 826570 109465 89690671
Foetal exposure during pregnancy 212.40 9.90 867 827444 42108 89758028
Fibromyalgia 209.90 9.90 2841 825470 203428 89596708
Hypotension 209.29 9.90 1932 826379 323465 89476671
Lactic acidosis 208.42 9.90 100 828211 50363 89749773
Somnolence 207.17 9.90 1094 827217 207990 89592146
Type 2 diabetes mellitus 203.81 9.90 2792 825519 200452 89599684
Hip arthroplasty 192.60 9.90 1275 827036 74933 89725203
Lower respiratory tract infection 191.92 9.90 3289 825022 247370 89552766
Knee arthroplasty 191.43 9.90 1360 826951 81822 89718314
Nasopharyngitis 187.86 9.90 4961 823350 402143 89397993
Hypersensitivity 187.45 9.90 5461 822850 449216 89350920
Drug ineffective for unapproved indication 186.47 9.90 200 828111 66444 89733692
Gestational diabetes 185.45 9.90 341 827970 10241 89789895
Treatment failure 183.89 9.90 3846 824465 300082 89500054
C-reactive protein abnormal 182.81 9.90 1875 826436 125554 89674582
Blood cholesterol increased 177.99 9.90 2780 825531 205232 89594904
Bradycardia 175.89 9.90 310 828001 83537 89716599
Agitation 175.10 9.90 213 828098 66885 89733251
Myelosuppression 174.55 9.90 140 828171 53451 89746685
Ill-defined disorder 170.17 9.90 2502 825809 182389 89617747
Cardiac failure 167.52 9.90 481 827830 109015 89691121
Tremor 166.90 9.90 775 827536 152398 89647738
Diarrhoea 166.56 9.90 6957 821354 932233 88867903
Neoplasm progression 166.38 9.90 100 828211 44386 89755750
Hyponatraemia 161.80 9.90 649 827662 132889 89667247
Sickle cell anaemia with crisis 159.11 9.90 259 828052 7038 89793098
Liver injury 158.47 9.90 2312 825999 168255 89631881
Stomatitis 157.39 9.90 3449 824862 271249 89528887
Red blood cell sedimentation rate abnormal 156.99 9.90 533 827778 23671 89776465
Osteoarthritis 155.15 9.90 2583 825728 193147 89606989
Renal failure 154.77 9.90 643 827668 130364 89669772
Neuropathy peripheral 150.42 9.90 691 827620 136279 89663857
Angioedema 148.07 9.90 227 828084 64649 89735487
Serotonin syndrome 147.64 9.90 81 828230 37806 89762330
Rhabdomyolysis 145.44 9.90 152 828159 51104 89749032
Cognitive disorder 144.33 9.90 258 828053 69149 89730987
Drug reaction with eosinophilia and systemic symptoms 143.95 9.90 108 828203 42650 89757486
Respiratory arrest 140.67 9.90 64 828247 33247 89766889
Chest discomfort 139.80 9.90 719 827592 137646 89662490
Myalgia 139.07 9.90 982 827329 174143 89625993
Off label use 136.50 9.90 8471 819840 1093781 88706355
Contusion 133.20 9.90 3120 825191 248096 89552040
Syncope 132.55 9.90 692 827619 131971 89668165
COVID-19 131.05 9.90 953 827358 167890 89632246
Small for dates baby 130.55 9.90 193 828118 4814 89795322
Pregnancy 129.93 9.90 992 827319 61055 89739081
Intentional product misuse 129.58 9.90 404 827907 89200 89710936
Drug resistance 129.37 9.90 58 828253 30391 89769745
Renal impairment 129.19 9.90 510 827801 104911 89695225
Respiratory failure 129.08 9.90 599 827712 117819 89682317
Neutrophil count decreased 127.31 9.90 291 828020 71241 89728895
General physical health deterioration 127.03 9.90 4193 824118 350922 89449214
No adverse event 126.38 9.90 270 828041 67712 89732424
Hypoglycaemia 126.06 9.90 282 828029 69566 89730570
Injury 125.08 9.90 2515 825796 194834 89605302
Thrombocytopenia 123.66 9.90 1264 827047 207461 89592675
Cytokine release syndrome 122.48 9.90 51 828260 27922 89772214
Cardio-respiratory arrest 121.39 9.90 246 828065 62894 89737242
Intentional product use issue 120.32 9.90 2711 825600 214181 89585955
Intentional self-injury 119.81 9.90 59 828252 29275 89770861
Oedema 119.53 9.90 2530 825781 197765 89602371
Sedation complication 117.48 9.90 10 828301 16934 89783202
Product dose omission issue 117.05 9.90 1917 826394 289770 89510366
Balance disorder 116.83 9.90 473 827838 96607 89703529
Joint range of motion decreased 116.03 9.90 1813 826498 133830 89666306
White blood cell count decreased 115.34 9.90 974 827337 166135 89634001
Vision blurred 114.90 9.90 567 827744 109726 89690410
Palpitations 114.86 9.90 754 827557 135974 89664162
Tachycardia 114.30 9.90 907 827404 156766 89643370
Device expulsion 112.93 9.90 124 828187 40762 89759374
Inflammation 112.84 9.90 2275 826036 176317 89623819
Metabolic acidosis 112.17 9.90 211 828100 55465 89744671
Dry skin 111.82 9.90 420 827891 87653 89712483
Live birth 111.52 9.90 1160 827151 77947 89722189
Coma 111.13 9.90 319 827992 72313 89727823
Sopor 111.05 9.90 43 828268 24601 89775535
Facet joint syndrome 110.42 9.90 1380 826931 97009 89703127
Hepatic failure 109.17 9.90 121 828190 39607 89760529
Multiple organ dysfunction syndrome 109.11 9.90 294 828017 68042 89732094
Blood glucose increased 107.87 9.90 475 827836 94771 89705365
Hypoxia 107.85 9.90 322 827989 72077 89728059
Accidental exposure to product 106.87 9.90 138 828173 42228 89757908
Multiple sclerosis relapse 106.45 9.90 197 828114 52108 89748028
Abortion spontaneous 106.42 9.90 852 827459 53204 89746932
Metastases to bone 103.11 9.90 52 828259 25453 89774683
Hyperglycaemia 102.83 9.90 193 828118 50777 89749359
Orthostatic hypotension 102.70 9.90 139 828172 41688 89758448
Grip strength decreased 101.98 9.90 1294 827017 91282 89708854
Congenital umbilical hernia 98.19 9.90 52 828259 284 89799852
Hepatic function abnormal 98.10 9.90 170 828141 46118 89754018
Feeling abnormal 97.70 9.90 1016 827295 166219 89633917
Anxiety 97.64 9.90 2122 826189 307650 89492486
Anaphylactic reaction 97.60 9.90 439 827872 87085 89713051
Seizure 96.81 9.90 909 827402 151720 89648416
Lip dry 95.52 9.90 1373 826938 99582 89700554
Palmar-plantar erythrodysaesthesia syndrome 95.34 9.90 70 828241 27953 89772183
Anaemia 94.58 9.90 2477 825834 350325 89449811
Dysphagia 94.38 9.90 619 827692 111659 89688477
Creatinine renal clearance decreased 93.80 9.90 28 828283 18871 89781265
Skin exfoliation 93.46 9.90 313 827998 67600 89732536
Food allergy 92.88 9.90 59 828252 25419 89774717
Peripheral swelling 92.81 9.90 4641 823670 408465 89391671
Drug withdrawal syndrome 92.33 9.90 76 828235 28647 89771489
Nasal oedema 90.95 9.90 192 828119 6392 89793744
Platelet count decreased 90.65 9.90 807 827504 136162 89663974
Pulmonary fibrosis 90.46 9.90 1433 826878 106070 89694066
Back pain 88.98 9.90 2212 826099 314963 89485173
Weight increased 88.95 9.90 4671 823640 413256 89386880
Dysarthria 88.80 9.90 232 828079 54250 89745886
Suicidal ideation 88.76 9.90 360 827951 73495 89726641
Cardiac failure congestive 88.69 9.90 533 827778 98161 89701975
Dehydration 88.20 9.90 1248 827063 193199 89606937
Sinusitis 87.18 9.90 3902 824409 339186 89460950
Mobility decreased 86.89 9.90 2950 825361 247784 89552352
Drug dependence 86.59 9.90 84 828227 29243 89770893
Hallucination 86.05 9.90 311 828000 65648 89734488
Wrong technique in product usage process 85.31 9.90 350 827961 71221 89728915
Anaphylactic shock 85.02 9.90 98 828213 31519 89768617
Blood pressure diastolic abnormal 84.31 9.90 383 827928 19498 89780638
Blood pressure systolic abnormal 83.17 9.90 376 827935 19102 89781034
Mydriasis 82.65 9.90 18 828293 14994 89785142
Sepsis 82.64 9.90 1151 827160 178663 89621473
Shock 82.03 9.90 85 828226 28693 89771443
Asthenia 81.79 9.90 4015 824296 529736 89270400
Diabetic ketoacidosis 81.71 9.90 62 828249 24345 89775791
Deep vein thrombosis postoperative 81.09 9.90 997 827314 69812 89730324
Altered state of consciousness 80.27 9.90 102 828209 31430 89768706
Condition aggravated 79.65 9.90 6397 821914 589148 89210988
Ventricular tachycardia 78.65 9.90 66 828245 24642 89775494
Obesity 77.62 9.90 1376 826935 104131 89696005
Cytomegalovirus infection 77.62 9.90 77 828234 26525 89773611
Disability assessment scale score increased 77.01 9.90 133 828178 3798 89796338
Neurotoxicity 76.50 9.90 51 828260 21416 89778720
Rash 76.05 9.90 8348 819963 787752 89012384
Schizophrenia 76.04 9.90 21 828290 14893 89785243
Product use in unapproved indication 75.89 9.90 2417 825894 333819 89466317
Restlessness 75.87 9.90 131 828180 35589 89764547
C-reactive protein increased 75.74 9.90 2183 826128 179206 89620930
Rash erythematous 75.35 9.90 322 827989 64782 89735354
Dizziness 75.00 9.90 4515 823796 584769 89215367
Flushing 74.80 9.90 487 827824 88004 89712132
Personality disorder 74.75 9.90 12 828299 12432 89787704
Myocardial infarction 74.31 9.90 615 827696 105357 89694779
Respiratory depression 73.87 9.90 25 828286 15550 89784586
Drug level increased 73.63 9.90 87 828224 27675 89772461
Dermatitis atopic 73.13 9.90 64 828247 23408 89776728
Metastases to liver 72.49 9.90 94 828217 28713 89771423
Joint effusion 72.20 9.90 364 827947 19346 89780790
Ejection fraction decreased 72.09 9.90 80 828231 26173 89773963
Device difficult to use 71.95 9.90 35 828276 17490 89782646
Infection 71.85 9.90 4021 824290 358073 89442063
Blood calcium decreased 70.42 9.90 104 828207 30078 89770058
Fatigue 70.08 9.90 11778 816533 1142245 88657891
Wheezing 69.32 9.90 2747 825564 235333 89564803
Encephalopathy 68.14 9.90 208 828103 46236 89753900
Neurologic neglect syndrome 67.98 9.90 3 828308 8844 89791292
Foot deformity 67.92 9.90 839 827472 58812 89741324
Wound infection 67.03 9.90 1355 826956 105047 89695089
Blood pressure decreased 67.01 9.90 405 827906 74490 89725646
Ascites 66.39 9.90 219 828092 47521 89752615
Torsade de pointes 65.95 9.90 28 828283 15154 89784982
Dyspnoea 65.94 9.90 7048 821263 873907 88926229
Disturbance in attention 65.59 9.90 216 828095 46893 89753243
Hypercholesterolaemia 65.29 9.90 1290 827021 99602 89700534
Therapy partial responder 65.24 9.90 63 828248 21980 89778156
Acute hepatic failure 65.03 9.90 66 828245 22495 89777641
Metastases to central nervous system 64.80 9.90 40 828271 17502 89782634
Depressed mood 64.72 9.90 238 828073 49984 89750152
Unresponsive to stimuli 64.70 9.90 159 828152 37962 89762174
Erythema 64.46 9.90 1598 826713 227648 89572488
Disease recurrence 63.94 9.90 157 828154 37496 89762640
Exposure via skin contact 62.81 9.90 11 828300 10694 89789442
Autoimmune disorder 62.31 9.90 1017 827294 75727 89724409
Skin haemorrhage 62.24 9.90 62 828249 21318 89778818
Atrial septal defect 62.16 9.90 191 828120 8043 89792093
Emotional distress 62.16 9.90 153 828158 36509 89763627
Blood creatine phosphokinase increased 61.68 9.90 137 828174 33886 89766250
Fluid retention 61.41 9.90 512 827799 87579 89712557
Cerebrovascular accident 61.39 9.90 778 827533 122755 89677381
Red blood cell sedimentation rate increased 61.39 9.90 1079 827232 81516 89718620
Blood creatinine increased 61.24 9.90 611 827700 100775 89699361
Arthritis 61.12 9.90 1981 826330 165334 89634802
Extrapyramidal disorder 60.47 9.90 37 828274 16266 89783870
Exposure to toxic agent 60.25 9.90 3 828308 7964 89792172
Blood pressure systolic increased 60.25 9.90 806 827505 57539 89742597
Basal cell carcinoma 60.22 9.90 516 827795 32873 89767263
Akathisia 60.19 9.90 14 828297 11145 89788991
Joint destruction 60.15 9.90 261 828050 13026 89787110
Headache 59.86 9.90 6938 821373 855808 88944328
Juvenile idiopathic arthritis 59.67 9.90 120 828191 3857 89796279
Musculoskeletal pain 59.58 9.90 2016 826295 169235 89630901
Adjustment disorder with depressed mood 59.43 9.90 786 827525 55967 89744169
Parkinsonism 59.42 9.90 27 828284 14038 89786098
Mental status changes 59.39 9.90 209 828102 44470 89755666
Dislocation of vertebra 59.39 9.90 777 827534 55191 89744945
Caesarean section 59.10 9.90 330 827981 18247 89781889
Polyarthritis 59.07 9.90 327 827984 18023 89782113
Carotid artery thrombosis 58.78 9.90 7 828304 9085 89791051
Blood bilirubin increased 58.69 9.90 202 828109 43268 89756868
Poisoning 58.61 9.90 33 828278 15184 89784952
Withdrawal syndrome 58.23 9.90 72 828239 22452 89777684
Loss of consciousness 57.41 9.90 918 827393 139320 89660816
Sciatica 57.36 9.90 1271 827040 100111 89700025
Hypomania 57.15 9.90 7 828304 8890 89791246
Aphasia 57.08 9.90 200 828111 42612 89757524
Temperature regulation disorder 57.05 9.90 31 828280 14548 89785588
Blood pressure fluctuation 56.60 9.90 730 827581 51683 89748453
Swollen tongue 56.49 9.90 222 828089 45734 89754402
Pain in jaw 56.35 9.90 236 828075 47749 89752387
Peripheral venous disease 56.32 9.90 1079 827232 82842 89717294
Ventricular septal defect 56.25 9.90 141 828170 5266 89794870
Hyperkalaemia 56.19 9.90 355 827956 64609 89735527
Hemiparesis 56.16 9.90 130 828181 31689 89768447
Psychotic disorder 55.60 9.90 127 828184 31103 89769033
Leukopenia 55.52 9.90 620 827691 100090 89700046
Bone pain 55.02 9.90 336 827975 61647 89738489
Disorientation 54.93 9.90 212 828099 43902 89756234
Dysgeusia 54.84 9.90 270 828041 52290 89747846
Cough 54.59 9.90 2785 825526 366177 89433959
Dysmorphism 54.44 9.90 90 828221 2478 89797658
Eating disorder 54.28 9.90 109 828202 27964 89772172
Nasal polyps 54.21 9.90 16 828295 10864 89789272
Muscle spasticity 54.12 9.90 155 828156 35167 89764969
Posterior reversible encephalopathy syndrome 54.07 9.90 75 828236 22264 89777872
Thrombotic microangiopathy 53.98 9.90 39 828272 15704 89784432
Gait inability 53.74 9.90 1735 826576 144721 89655415
Bursitis 53.72 9.90 1580 826731 130074 89670062
Blood alkaline phosphatase increased 53.69 9.90 241 828070 47838 89752298
Haematotoxicity 53.06 9.90 24 828287 12511 89787625
Breast cancer stage III 53.05 9.90 1075 827236 83372 89716764
Illness 52.89 9.90 486 827825 81483 89718653
Chronic kidney disease 52.85 9.90 257 828054 49934 89750202
Hypokalaemia 52.77 9.90 861 827450 130255 89669881
Pulmonary embolism 52.34 9.90 860 827451 129960 89670176
Pulmonary oedema 52.29 9.90 342 827969 61738 89738398
Hepatotoxicity 52.27 9.90 228 828083 45614 89754522
Ventricular fibrillation 51.91 9.90 32 828279 14012 89786124
Joint laxity 51.59 9.90 89 828222 2539 89797597
Gamma-glutamyltransferase increased 51.48 9.90 176 828135 37776 89762360
Post transplant lymphoproliferative disorder 51.36 9.90 3 828308 6946 89793190
Bone erosion 51.30 9.90 724 827587 52297 89747839
Aspartate aminotransferase increased 51.25 9.90 648 827663 102289 89697847
Abnormal behaviour 50.84 9.90 80 828231 22548 89777588
Lethargy 50.60 9.90 353 827958 62786 89737350
Eye pruritus 50.11 9.90 120 828191 28907 89771229
Brain oedema 49.94 9.90 51 828260 17334 89782802
Osteonecrosis of jaw 49.93 9.90 186 828125 38917 89761219
Polyneuropathy 49.82 9.90 62 828249 19279 89780857
Hypomagnesaemia 49.66 9.90 163 828148 35425 89764711
Dyskinesia 49.16 9.90 170 828141 36364 89763772
Hypothermia 49.09 9.90 42 828269 15533 89784603
Premature labour 48.98 9.90 247 828064 13129 89787007
Road traffic accident 48.76 9.90 1309 827002 106317 89693819
Dystonia 48.70 9.90 49 828262 16770 89783366
Bronchospasm 48.67 9.90 71 828240 20638 89779498
Muscle twitching 48.50 9.90 92 828219 24110 89776026
Alanine aminotransferase increased 48.31 9.90 775 827536 117563 89682573
Angina pectoris 48.24 9.90 189 828122 38971 89761165
Speech disorder 48.24 9.90 233 828078 45352 89754784
Atrial fibrillation 47.81 9.90 896 827415 132715 89667421
Prescribed underdose 47.79 9.90 957 827354 74062 89726074
Status epilepticus 47.07 9.90 62 828249 18812 89781324
Second primary malignancy 46.94 9.90 18 828293 10360 89789776
Respiratory distress 46.69 9.90 190 828121 38756 89761380
Adjustment disorder 46.57 9.90 15 828296 9627 89790509
Vertigo 46.31 9.90 411 827900 69400 89730736
Proteinuria 46.27 9.90 89 828222 23202 89776934
Adverse event 46.24 9.90 1403 826908 116015 89684121
Cholestasis 46.13 9.90 173 828138 36126 89764010
Arrhythmia 45.60 9.90 215 828096 42117 89758019
Miosis 45.37 9.90 15 828296 9469 89790667
Gastrointestinal disorder 45.27 9.90 2821 825490 253866 89546270
Arterial occlusive disease 45.12 9.90 29 828282 12417 89787719
Disseminated intravascular coagulation 44.83 9.90 80 828231 21458 89778678
Irritability 44.65 9.90 171 828140 35491 89764645
Acute respiratory failure 44.47 9.90 221 828090 42697 89757439
Multiple drug therapy 43.85 9.90 6 828305 7003 89793133
Inappropriate antidiuretic hormone secretion 43.78 9.90 69 828242 19436 89780700
Stevens-Johnson syndrome 43.49 9.90 131 828180 29245 89770891
Mania 43.41 9.90 39 828272 14085 89786051
Muscle rigidity 43.40 9.90 40 828271 14269 89785867
Transplant rejection 43.23 9.90 32 828279 12726 89787410
Motor dysfunction 43.19 9.90 68 828243 19162 89780974
Eczema 43.15 9.90 294 828017 52576 89747560
Cytopenia 42.82 9.90 58 828253 17391 89782745
Joint stiffness 42.76 9.90 974 827337 77068 89723068
Onychomycosis 42.67 9.90 526 827785 36850 89763286
Coordination abnormal 42.08 9.90 82 828229 21274 89778862
Lower limb fracture 41.71 9.90 1045 827266 83968 89716168
Hospitalisation 41.62 9.90 873 827438 127227 89672909
Aggression 41.62 9.90 116 828195 26552 89773584
Forced expiratory volume decreased 41.47 9.90 3 828308 5805 89794331
Myocarditis 41.39 9.90 39 828272 13767 89786369
Rebound effect 41.26 9.90 17 828294 9367 89790769
Colitis 41.20 9.90 424 827887 69518 89730618
Haemorrhage 41.08 9.90 420 827891 68949 89731187
Cerebral haemorrhage 41.02 9.90 169 828142 34353 89765783
Pleural effusion 41.00 9.90 748 827563 111243 89688893
Graft versus host disease 40.54 9.90 12 828299 8132 89792004
Sensory loss 40.52 9.90 64 828247 18011 89782125
Affect lability 40.45 9.90 64 828247 17999 89782137
Metastases to lung 40.42 9.90 52 828259 15939 89784197
Vomiting 40.23 9.90 6460 821851 781833 89018303
Obstructive airways disorder 40.02 9.90 113 828198 25756 89774380
Cardiogenic shock 40.02 9.90 104 828207 24364 89775772
Face oedema 39.77 9.90 97 828214 23221 89776915
Drug dose omission by device 39.68 9.90 22 828289 10209 89789927
Chills 39.56 9.90 911 827400 131070 89669066
Sinus tachycardia 39.51 9.90 131 828180 28382 89771754
Bronchopulmonary aspergillosis 39.39 9.90 28 828283 11370 89788766
Hemiplegia 39.37 9.90 54 828257 16106 89784030
Tuberculosis 39.31 9.90 222 828089 12327 89787809
Neuroleptic malignant syndrome 39.30 9.90 48 828263 15048 89785088
Osteoporosis 38.97 9.90 1157 827154 95374 89704762
Neck deformity 38.94 9.90 71 828240 2118 89798018
Coagulopathy 38.85 9.90 98 828213 23191 89776945
Sleep disorder 38.81 9.90 2197 826114 195833 89604303
Mental disorder 38.53 9.90 158 828153 32160 89767976
Premature rupture of membranes 38.36 9.90 125 828186 5433 89794703
Lymphocyte count decreased 38.35 9.90 177 828134 34873 89765263
Atrioventricular block complete 38.19 9.90 21 828290 9790 89790346
Rhinitis allergic 38.04 9.90 59 828252 16726 89783410
Gastrointestinal haemorrhage 37.86 9.90 588 827723 89660 89710476
Venoocclusive liver disease 37.81 9.90 5 828306 5988 89794148
Respiratory tract infection 37.75 9.90 754 827557 58324 89741812
Tardive dyskinesia 37.58 9.90 27 828284 10903 89789233
Lung disorder 37.20 9.90 1701 826610 148182 89651954
Device use error 37.13 9.90 10 828301 7211 89792925
Onychomadesis 37.12 9.90 609 827702 45389 89754747
Hyperlipidaemia 37.02 9.90 98 828213 22818 89777318
Psoriasis 36.93 9.90 1678 826633 146076 89654060
Swelling face 36.91 9.90 522 827789 80830 89719306
Aspergillus infection 36.86 9.90 27 828284 10796 89789340
Diabetes mellitus 36.70 9.90 397 827914 64478 89735658
Drug tolerance decreased 36.61 9.90 452 827859 31678 89768458
Haemorrhage intracranial 36.60 9.90 51 828260 15111 89785025
Tinnitus 36.53 9.90 237 828074 42865 89757271
C-reactive protein 36.49 9.90 443 827868 30924 89769212
Infusion site pain 36.17 9.90 79 828232 19659 89780477
Tachypnoea 36.07 9.90 89 828222 21220 89778916
Dyspnoea exertional 36.01 9.90 455 827856 71833 89728303
Acute graft versus host disease 35.88 9.90 4 828307 5464 89794672
Nightmare 35.79 9.90 92 828219 21633 89778503
Hepatic cytolysis 35.71 9.90 153 828158 30763 89769373
Gangrene 35.61 9.90 39 828272 12837 89787299
Maternal exposure before pregnancy 35.55 9.90 199 828112 11014 89789122
Cardiotoxicity 35.55 9.90 31 828280 11358 89788778
Lip swelling 35.48 9.90 207 828104 38403 89761733
Substance abuse 35.36 9.90 4 828307 5402 89794734
Mucosal inflammation 35.32 9.90 346 827965 57279 89742857
Maternal drugs affecting foetus 34.74 9.90 115 828196 5040 89795096
Loss of personal independence in daily activities 34.73 9.90 1549 826762 134556 89665580
Anti-cyclic citrullinated peptide antibody 34.57 9.90 391 827920 26830 89773306
Product preparation error 34.43 9.90 26 828285 10235 89789901
Asphyxia 34.39 9.90 11 828300 7092 89793044
Acute generalised exanthematous pustulosis 34.18 9.90 45 828266 13658 89786478
Tumour lysis syndrome 34.03 9.90 31 828280 11121 89789015
Acute chest syndrome 33.97 9.90 47 828264 1101 89799035
Asthma-chronic obstructive pulmonary disease overlap syndrome 33.67 9.90 3 828308 4896 89795240
Blood pressure diastolic decreased 33.47 9.90 384 827927 26442 89773694
Nodule 33.30 9.90 382 827929 26304 89773832
Inappropriate schedule of product administration 33.24 9.90 1080 827231 148853 89651283
Stress cardiomyopathy 33.17 9.90 44 828267 13311 89786825
Heart rate increased 33.08 9.90 782 827529 112120 89688016
Complication of device insertion 33.07 9.90 28 828283 10408 89789728
Cerebral infarction 32.99 9.90 128 828183 26468 89773668
Pseudomonas infection 32.97 9.90 53 828258 14812 89785324
Pancreatitis acute 32.92 9.90 166 828145 31949 89768187
Injection site reaction 32.78 9.90 1087 827224 90993 89709143
Dysuria 32.71 9.90 218 828093 39183 89760953
Nervousness 32.69 9.90 180 828131 33876 89766260
Epistaxis 32.61 9.90 564 827747 84561 89715575
Fall 32.35 9.90 3882 824429 477928 89322208
X-ray abnormal 32.19 9.90 589 827722 44835 89755301
Device related infection 32.05 9.90 124 828187 25662 89774474
Laryngitis 31.84 9.90 646 827665 50107 89750029
Lupus-like syndrome 31.74 9.90 625 827686 48221 89751915
Toxic skin eruption 31.58 9.90 60 828251 15714 89784422
Bradyphrenia 31.56 9.90 15 828296 7597 89792539
Influenza like illness 31.56 9.90 532 827779 80079 89720057
Developmental hip dysplasia 31.54 9.90 54 828257 1531 89798605
Complication of device removal 31.53 9.90 9 828302 6246 89793890
Panic attack 31.37 9.90 129 828182 26236 89773900
Pulmonary arterial hypertension 31.24 9.90 128 828183 26059 89774077
Vascular device infection 31.12 9.90 38 828273 11914 89788222
Sinus disorder 30.95 9.90 186 828125 34261 89765875
Hot flush 30.92 9.90 371 827940 59117 89741019
Hypothyroidism 30.91 9.90 323 827988 52804 89747332
Diabetes mellitus inadequate control 30.87 9.90 79 828232 18605 89781531
Infective pulmonary exacerbation of cystic fibrosis 30.86 9.90 29 828282 10250 89789886
Skin burning sensation 30.83 9.90 85 828226 19526 89780610
Pathogen resistance 30.68 9.90 18 828293 8097 89792039
Genital haemorrhage 30.57 9.90 21 828290 8681 89791455
Disability 30.53 9.90 533 827778 40212 89759924
Dry mouth 30.46 9.90 2012 826299 182047 89618089
Pre-eclampsia 30.46 9.90 189 828122 10859 89789277
Glycosylated haemoglobin increased 30.45 9.90 60 828251 15502 89784634
Device dislocation 30.44 9.90 166 828145 31316 89768820
Large for dates baby 30.08 9.90 30 828281 489 89799647
Chronic obstructive pulmonary disease 29.97 9.90 484 827827 73345 89726791
Acute graft versus host disease in skin 29.93 9.90 4 828307 4752 89795384
Haemophagocytic lymphohistiocytosis 29.91 9.90 60 828251 15399 89784737
Haemoptysis 29.89 9.90 180 828131 33140 89766996
Acute myeloid leukaemia 29.87 9.90 93 828218 20547 89779589
Joint dislocation 29.84 9.90 573 827738 44009 89756127
Erythema multiforme 29.75 9.90 41 828270 12205 89787931
Macular degeneration 29.59 9.90 214 828097 37756 89762380
Respiratory disorder neonatal 29.56 9.90 49 828262 1352 89798784
International normalised ratio increased 29.47 9.90 283 828028 47033 89753103
Wheelchair user 29.38 9.90 145 828166 7640 89792496
Jaundice cholestatic 29.38 9.90 29 828282 10014 89790122
Paralysis 29.35 9.90 37 828274 11441 89788695
Sleep apnoea syndrome 29.28 9.90 170 828141 31577 89768559
Multiple fractures 29.19 9.90 168 828143 9394 89790742
Fear 28.47 9.90 69 828242 16553 89783583
Hypophosphataemia 28.44 9.90 58 828253 14796 89785340
Foetal anticonvulsant syndrome 28.43 9.90 33 828278 644 89799492
Product prescribing issue 28.37 9.90 19 828292 7960 89792176
Pancytopenia 28.37 9.90 1358 826953 118905 89681231
Multiple-drug resistance 28.35 9.90 18 828293 7758 89792378
Ketoacidosis 28.30 9.90 8 828303 5587 89794549
Latent tuberculosis 28.27 9.90 75 828236 2901 89797235
Breast cancer metastatic 28.20 9.90 60 828251 15072 89785064
Haematoma 28.10 9.90 225 828086 38823 89761313
Tenderness 28.08 9.90 372 827939 26496 89773640
Pericardial effusion 28.02 9.90 209 828102 36624 89763512
Respiratory acidosis 27.99 9.90 20 828291 8099 89792037
Lymphopenia 27.82 9.90 111 828200 22770 89777366
Hypophagia 27.78 9.90 203 828108 35734 89764402
Crying 27.77 9.90 130 828181 25515 89774621
Blood glucose decreased 27.65 9.90 115 828196 23314 89776822
Rheumatoid nodule 27.60 9.90 294 828017 19872 89780264
Pulmonary hypertension 27.48 9.90 252 828059 42271 89757865
Multiple allergies 27.44 9.90 61 828250 15085 89785051
Acute respiratory distress syndrome 27.32 9.90 152 828159 28534 89771602
Dysphonia 27.14 9.90 409 827902 62675 89737461
Birth mark 26.89 9.90 18 828293 160 89799976
Graft versus host disease in gastrointestinal tract 26.89 9.90 4 828307 4384 89795752
Hepatic cirrhosis 26.86 9.90 763 827548 62490 89737646
Hepatocellular injury 26.74 9.90 155 828156 28803 89771333
Eye irritation 26.72 9.90 191 828120 33787 89766349
Exostosis 26.62 9.90 655 827656 52479 89747657
Delusion 26.53 9.90 54 828257 13786 89786350
Complication associated with device 26.51 9.90 90 828221 19359 89780777
Toxic epidermal necrolysis 26.49 9.90 181 828130 32347 89767789
Colitis microscopic 26.48 9.90 38 828273 11121 89789015
Lupus vulgaris 26.47 9.90 568 827743 44491 89755645
Treatment noncompliance 26.35 9.90 324 827987 51403 89748733
Pain in extremity 26.25 9.90 4590 823721 445939 89354197
Melaena 26.21 9.90 198 828113 34599 89765537
Breast cancer female 26.12 9.90 61 828250 14825 89785311
Paradoxical drug reaction 26.08 9.90 10 828301 5756 89794380
Sexual dysfunction 25.97 9.90 6 828305 4798 89795338
Jaundice 25.95 9.90 182 828129 32335 89767801
Myoclonus 25.92 9.90 89 828222 19079 89781057
Device breakage 25.91 9.90 56 828255 13988 89786148
Cytomegalovirus infection reactivation 25.87 9.90 20 828291 7780 89792356
Pulmonary congestion 25.76 9.90 91 828220 19342 89780794
Respiratory tract congestion 25.70 9.90 146 828165 27264 89772872
Urinary retention 25.57 9.90 221 828090 37523 89762613
Cleft lip and palate 25.51 9.90 33 828278 723 89799413
Heart rate decreased 25.45 9.90 655 827656 52850 89747286
Sneezing 25.43 9.90 164 828147 29705 89770431
Febrile bone marrow aplasia 25.31 9.90 31 828280 9707 89790429
Middle insomnia 25.30 9.90 74 828237 16677 89783459
Dissociation 25.24 9.90 15 828296 6700 89793436
Hypoaesthesia 25.23 9.90 3260 825051 310950 89489186
Therapy interrupted 25.10 9.90 315 827996 49793 89750343
Blood potassium decreased 25.06 9.90 297 828014 47430 89752706
Mood altered 24.99 9.90 77 828234 17067 89783069
Retinitis 24.96 9.90 492 827819 37966 89762170
Deep vein thrombosis 24.83 9.90 642 827669 90978 89709158
Product administered to patient of inappropriate age 24.78 9.90 6 828305 4647 89795489
Clostridium difficile colitis 24.63 9.90 143 828168 26563 89773573
Blood test abnormal 24.63 9.90 103 828208 20849 89779287
Mucormycosis 24.56 9.90 3 828308 3818 89796318
Pallor 24.52 9.90 197 828114 33968 89766168
Toxic encephalopathy 24.45 9.90 26 828285 8673 89791463
Hypervolaemia 24.39 9.90 187 828124 32570 89767566
Eosinophil count increased 24.27 9.90 52 828259 13029 89787107
Bacteraemia 24.17 9.90 113 828198 22187 89777949
Incorrect dose administered 24.16 9.90 543 827768 78387 89721749
Sinus bradycardia 24.10 9.90 77 828234 16875 89783261
Myopathy 24.04 9.90 55 828256 13463 89786673
Throat tightness 24.04 9.90 164 828147 29320 89770816
Glomerular filtration rate decreased 24.01 9.90 77 828234 16855 89783281
Polyuria 24.01 9.90 34 828277 10006 89790130
Limb deformity 23.97 9.90 88 828223 4064 89796072
Aspiration 23.94 9.90 69 828242 15624 89784512
Epstein-Barr virus infection 23.78 9.90 36 828275 10308 89789828
Device issue 23.73 9.90 165 828146 29372 89770764
Product administration interrupted 23.73 9.90 49 828262 12443 89787693
Pulseless electrical activity 23.68 9.90 28 828283 8904 89791232
Product administration error 23.57 9.90 143 828168 26280 89773856
Leukocytosis 23.50 9.90 176 828135 30814 89769322
Dyspepsia 23.46 9.90 2110 826201 196050 89604086
Anuria 23.46 9.90 64 828247 14754 89785382
Placental disorder 23.45 9.90 48 828263 1563 89798573
Paranoia 23.38 9.90 52 828259 12856 89787280
Acidosis 23.32 9.90 51 828260 12685 89787451
Head injury 23.24 9.90 178 828133 31010 89769126
Schizoaffective disorder 23.16 9.90 9 828302 5138 89794998
Rales 23.13 9.90 71 828240 15756 89784380
Product adhesion issue 23.12 9.90 9 828302 5133 89795003
Therapeutic response shortened 23.03 9.90 119 828192 22760 89777376
Ileus 22.94 9.90 76 828235 16470 89783666
Electrocardiogram QRS complex prolonged 22.93 9.90 20 828291 7328 89792808
Smear cervix abnormal 22.90 9.90 72 828239 3070 89797066
Stillbirth 22.87 9.90 131 828180 7312 89792824
Product storage error 22.87 9.90 101 828210 20140 89779996
Body temperature decreased 22.55 9.90 324 827987 23492 89776644
Transplant dysfunction 22.53 9.90 10 828301 5272 89794864
Oliguria 22.53 9.90 39 828272 10585 89789551
Blood pressure diastolic increased 22.52 9.90 198 828113 12708 89787428
Infusion site erythema 22.43 9.90 58 828253 13612 89786524
Hypernatraemia 22.24 9.90 32 828279 9355 89790781
Total lung capacity increased 22.23 9.90 9 828302 5012 89795124
Right ventricular failure 22.21 9.90 95 828216 19110 89781026
Tubulointerstitial nephritis 22.17 9.90 138 828173 25205 89774931
Respiration abnormal 22.16 9.90 24 828287 7939 89792197
Psychomotor hyperactivity 22.09 9.90 53 828258 12760 89787376
Talipes 22.07 9.90 48 828263 1632 89798504
Cyanosis 22.03 9.90 97 828214 19358 89780778
Enthesopathy 21.76 9.90 154 828157 9250 89790886
Malignant mediastinal neoplasm 21.75 9.90 43 828268 1365 89798771
Blood lactic acid increased 21.72 9.90 29 828282 8749 89791387
Nail disorder 21.72 9.90 700 827611 58367 89741769
Sputum discoloured 21.71 9.90 104 828207 20287 89779849
Multiple sclerosis 21.65 9.90 157 828154 27683 89772453
Urinary incontinence 21.60 9.90 229 828082 37337 89762799
Circulatory collapse 21.58 9.90 136 828175 24768 89775368
Cardiomyopathy 21.54 9.90 103 828208 20103 89780033
Malignant melanoma 21.46 9.90 192 828119 12384 89787752
Human herpesvirus 6 infection 21.33 9.90 3 828308 3429 89796707
Abdominal pain 21.32 9.90 3232 825079 392489 89407647
Speech disorder developmental 21.28 9.90 34 828277 909 89799227
Metastases to lymph nodes 21.24 9.90 47 828264 11642 89788494
Systemic inflammatory response syndrome 21.24 9.90 17 828294 6499 89793637
Bradypnoea 21.20 9.90 8 828303 4650 89795486
Antinuclear antibody positive 21.19 9.90 151 828160 9090 89791046
Adenovirus infection 20.93 9.90 8 828303 4614 89795522
Labelled drug-drug interaction medication error 20.90 9.90 66 828245 14516 89785620
Abortion late 20.87 9.90 14 828297 125 89800011
Dementia 20.83 9.90 130 828181 23731 89776405
Insurance issue 20.80 9.90 43 828268 10915 89789221
Chronic graft versus host disease 20.78 9.90 6 828305 4133 89796003
Hyperbilirubinaemia 20.74 9.90 62 828249 13874 89786262
Polyhydramnios 20.66 9.90 60 828251 2448 89797688
Ankylosing spondylitis 20.64 9.90 197 828114 12936 89787200
Blood pressure inadequately controlled 20.59 9.90 16 828295 6208 89793928
Body temperature increased 20.59 9.90 286 828025 44424 89755712
Bradykinesia 20.56 9.90 19 828292 6769 89793367
Seronegative arthritis 20.55 9.90 256 828055 17978 89782158
Graft versus host disease in skin 20.46 9.90 5 828306 3848 89796288
Rheumatoid lung 20.45 9.90 83 828228 4020 89796116
Subarachnoid haemorrhage 20.44 9.90 89 828222 17815 89782321
Product dose omission in error 20.44 9.90 107 828204 20396 89779740
Pulmonary tuberculosis 20.40 9.90 93 828218 4741 89795395
Presyncope 20.33 9.90 189 828122 31616 89768520
Immune-mediated enterocolitis 20.30 9.90 9 828302 4748 89795388
Eosinophilia 20.26 9.90 165 828146 28368 89771768
Blood urea increased 20.19 9.90 179 828132 30234 89769902
Immune effector cell-associated neurotoxicity syndrome 20.16 9.90 14 828297 5754 89794382
Rhinovirus infection 20.15 9.90 15 828296 5948 89794188
Coronary artery disease 20.14 9.90 203 828108 33420 89766716
Agitation neonatal 19.91 9.90 25 828286 531 89799605
Lymphoedema 19.88 9.90 62 828249 13691 89786445
Cytomegalovirus viraemia 19.87 9.90 24 828287 7562 89792574
Blepharospasm 19.85 9.90 655 827656 54790 89745346
Sleep terror 19.77 9.90 8 828303 4456 89795680
Renal disorder 19.72 9.90 236 828075 37623 89762513
Anti-neutrophil cytoplasmic antibody positive vasculitis 19.66 9.90 6 828305 3987 89796149
Post-traumatic stress disorder 19.65 9.90 20 828291 6808 89793328
Renal injury 19.61 9.90 40 828271 10203 89789933
Rotator cuff repair 19.54 9.90 58 828253 2396 89797740
Bone lesion 19.52 9.90 18 828293 6419 89793717
Diplopia 19.51 9.90 168 828143 28546 89771590
Exomphalos 19.45 9.90 25 828286 544 89799592
Lacrimation increased 19.44 9.90 156 828155 26906 89773230
Hypogammaglobulinaemia 19.33 9.90 43 828268 10631 89789505
Hyperprolactinaemia 19.23 9.90 13 828298 5420 89794716
Plasma cell myeloma 19.22 9.90 260 828051 40568 89759568
Visual acuity reduced 19.19 9.90 130 828181 23280 89776856
Premature delivery 19.17 9.90 477 827834 38285 89761851
Blindness 19.16 9.90 153 828158 26415 89773721
Thrombosis 19.13 9.90 516 827795 72735 89727401
Tumour marker increased 19.12 9.90 15 828296 5792 89794344
Hallucination, auditory 19.11 9.90 78 828233 15897 89784239
Finger deformity 19.10 9.90 414 827897 32483 89767653
Atrial tachycardia 19.07 9.90 16 828295 5974 89794162
Maternal exposure timing unspecified 19.01 9.90 300 828011 22183 89777953
Body height below normal 18.96 9.90 53 828258 2115 89798021
Pain of skin 18.94 9.90 79 828232 16003 89784133
Sleep disorder due to a general medical condition 18.92 9.90 291 828020 44447 89755689
Pyrexia 18.89 9.90 5567 822744 654918 89145218
Pharyngeal swelling 18.89 9.90 39 828272 9905 89790231
Pruritus genital 18.87 9.90 9 828302 4549 89795587
Rash maculo-papular 18.79 9.90 262 828049 40671 89759465
Synovial disorder 18.78 9.90 67 828244 3051 89797085
Prescribed overdose 18.71 9.90 1081 827230 96544 89703592
Generalised oedema 18.67 9.90 100 828211 18953 89781183
Unevaluable event 18.64 9.90 371 827940 54477 89745659
Immune reconstitution inflammatory syndrome 18.61 9.90 22 828289 6997 89793139
Pruritus 18.57 9.90 4528 823783 536997 89263139
Cardiac failure acute 18.53 9.90 52 828259 11877 89788259
Ear infection 18.43 9.90 797 827514 68978 89731158
Hereditary angioedema 18.42 9.90 36 828275 9329 89790807
Troponin increased 18.41 9.90 61 828250 13220 89786916
Temperature intolerance 18.28 9.90 53 828258 11977 89788159
Skin toxicity 18.24 9.90 21 828290 6758 89793378
Klebsiella infection 18.23 9.90 42 828269 10255 89789881
Synovial fluid analysis 18.22 9.90 62 828249 2756 89797380
Hypoglycaemia neonatal 18.22 9.90 35 828276 1087 89799049
Tenosynovitis stenosans 18.16 9.90 78 828233 3875 89796261
Infusion site pruritus 18.15 9.90 21 828290 6744 89793392
Neck mass 18.14 9.90 77 828234 3805 89796331
Atrioventricular block 18.11 9.90 33 828278 8782 89791354
Localised infection 18.11 9.90 418 827893 33144 89766992
Urinary tract infection 18.10 9.90 2482 825829 303150 89496986
Nail operation 18.07 9.90 48 828263 1858 89798278
Rash macular 18.06 9.90 183 828128 30097 89770039
Euglycaemic diabetic ketoacidosis 18.03 9.90 18 828293 6183 89793953
Feeling hot 17.98 9.90 559 827752 77449 89722687
Acute myocardial infarction 17.98 9.90 218 828093 34672 89765464
Extra dose administered 17.97 9.90 35 828276 9083 89791053
Pulmonary alveolar haemorrhage 17.92 9.90 17 828294 5981 89794155
Drug tolerance 17.88 9.90 246 828065 17670 89782466
Hyperuricaemia 17.88 9.90 21 828290 6698 89793438
Peripheral sensory neuropathy 17.81 9.90 36 828275 9214 89790922
Haemorrhage in pregnancy 17.74 9.90 52 828259 2133 89798003
Feeding disorder 17.67 9.90 91 828220 17421 89782715
Subdural haematoma 17.66 9.90 85 828226 16560 89783576
Generalised tonic-clonic seizure 17.64 9.90 219 828092 34684 89765452
Learning disorder 17.59 9.90 30 828281 848 89799288
Infusion site swelling 17.54 9.90 52 828259 11668 89788468
Limb reduction defect 17.53 9.90 25 828286 603 89799533
Breast feeding 17.46 9.90 30 828281 853 89799283
Night sweats 17.43 9.90 1385 826926 127381 89672755
Hyperlactacidaemia 17.38 9.90 8 828303 4128 89796008
Systemic candida 17.38 9.90 12 828299 4947 89795189
Pulmonary haemorrhage 17.37 9.90 29 828282 7984 89792152
Synovial cyst 17.35 9.90 174 828137 11578 89788558
Loose body in joint 17.22 9.90 39 828272 1363 89798773
Hypertelorism 17.20 9.90 23 828288 521 89799615
Patent ductus arteriosus 17.17 9.90 85 828226 4484 89795652
Affective disorder 17.08 9.90 28 828283 7765 89792371
Red blood cell sedimentation rate 17.04 9.90 86 828225 4572 89795564
Salivary hypersecretion 16.99 9.90 36 828275 9056 89791080
Gastroenteritis viral 16.98 9.90 380 827931 29975 89770161
Potentiating drug interaction 16.97 9.90 16 828295 5646 89794490
Impaired gastric emptying 16.97 9.90 60 828251 12749 89787387
Haemodynamic instability 16.91 9.90 53 828258 11686 89788450
Cardiac disorder 16.91 9.90 393 827918 56479 89743657
Anhedonia 16.90 9.90 51 828260 11380 89788756
Spinal stenosis 16.88 9.90 238 828073 17186 89782950
Restless legs syndrome 16.86 9.90 128 828183 22342 89777794
End stage renal disease 16.81 9.90 33 828278 8538 89791598
Anosmia 16.77 9.90 41 828270 9807 89790329
Candida infection 16.72 9.90 215 828096 33842 89766294
Retrognathia 16.55 9.90 23 828288 541 89799595
Bronchioloalveolar carcinoma 16.55 9.90 10 828301 73 89800063
Catheter site pain 16.45 9.90 16 828295 5563 89794573
Anaemia macrocytic 16.44 9.90 84 828227 4488 89795648
Nephropathy toxic 16.43 9.90 60 828251 12628 89787508
Laryngospasm 16.43 9.90 5 828306 3328 89796808
Cholelithiasis 16.42 9.90 360 827951 52146 89747990
Accidental overdose 16.40 9.90 172 828139 28101 89772035
Infantile vomiting 16.37 9.90 13 828298 154 89799982
Vasoplegia syndrome 16.27 9.90 3 828308 2811 89797325
Acute pulmonary oedema 16.22 9.90 40 828271 9540 89790596
Pneumonitis 16.17 9.90 295 828016 43875 89756261
Skin ulcer 16.03 9.90 584 827727 49491 89750645
Pancreatitis 15.94 9.90 501 827810 69325 89730811
Device leakage 15.93 9.90 43 828268 9948 89790188
Amylase increased 15.89 9.90 25 828286 7047 89793089
Injection site pruritus 15.84 9.90 622 827689 53212 89746924
Full blood count abnormal 15.84 9.90 237 828074 36360 89763776
Arthritis infective 15.74 9.90 126 828185 7866 89792270
Ventricular extrasystoles 15.66 9.90 65 828246 13185 89786951
Electrolyte imbalance 15.66 9.90 140 828171 23605 89776531
Bezoar 15.63 9.90 3 828308 2731 89797405
Pseudomonal sepsis 15.63 9.90 10 828301 4292 89795844
Amyloid arthropathy 15.62 9.90 42 828269 1638 89798498
Syndactyly 15.61 9.90 23 828288 572 89799564
Varicella zoster virus infection 15.53 9.90 8 828303 3869 89796267
Ankle arthroplasty 15.51 9.90 59 828252 2772 89797364
Diabetes insipidus 15.51 9.90 5 828306 3207 89796929
Pneumatosis intestinalis 15.48 9.90 6 828305 3431 89796705
Progressive multifocal leukoencephalopathy 15.44 9.90 82 828229 15573 89784563
Abortion threatened 15.37 9.90 23 828288 580 89799556
Congenital arterial malformation 15.37 9.90 17 828294 314 89799822
Clostridium test positive 15.34 9.90 16 828295 5385 89794751
Skin papilloma 15.33 9.90 96 828215 5534 89794602
Antibody test positive 15.32 9.90 61 828250 2928 89797208
Epidermal necrosis 15.32 9.90 52 828259 2309 89797827
Maternal exposure during delivery 15.31 9.90 8 828303 3838 89796298
Product substitution issue 15.27 9.90 99 828212 17909 89782227
Lung opacity 15.26 9.90 20 828291 6082 89794054
Clear cell renal cell carcinoma 15.19 9.90 40 828271 1540 89798596
Staphylococcal infection 15.18 9.90 332 827979 48107 89752029
Femur fracture 15.14 9.90 539 827772 45543 89754593
Abdominal distension 15.10 9.90 1009 827302 129592 89670544
Eye swelling 14.99 9.90 184 828127 29202 89770934
Human antichimeric antibody positive 14.97 9.90 43 828268 1743 89798393
Scleritis 14.93 9.90 90 828221 5118 89795018
Postoperative wound infection 14.92 9.90 188 828123 13238 89786898
Nystagmus 14.90 9.90 27 828284 7200 89792936
Needle issue 14.87 9.90 71 828240 13863 89786273
Hyperthyroidism 14.85 9.90 102 828209 18208 89781928
Congenital hypertrichosis 14.82 9.90 4 828307 0 89800136
Pneumonia viral 14.82 9.90 37 828274 8786 89791350
Hepatitis B reactivation 14.77 9.90 9 828302 3965 89796171
Mouth ulceration 14.76 9.90 474 827837 39500 89760636
Acute coronary syndrome 14.76 9.90 50 828261 10763 89789373
Congenital hydronephrosis 14.66 9.90 19 828292 417 89799719
Carotid artery occlusion 14.65 9.90 22 828289 6320 89793816
Anger 14.59 9.90 70 828241 13650 89786486
Personality change 14.52 9.90 28 828283 7293 89792843
Congenital cerebral cyst 14.49 9.90 15 828296 256 89799880
Trigeminal neuralgia 14.47 9.90 10 828301 4121 89796015
Pneumothorax 14.47 9.90 109 828202 19058 89781078
Metastasis 14.46 9.90 21 828290 6116 89794020
Blood sodium decreased 14.43 9.90 172 828139 27441 89772695
Tetany 14.43 9.90 3 828308 2581 89797555
Hallucination, visual 14.43 9.90 138 828173 22954 89777182
Hepatitis acute 14.42 9.90 51 828260 10836 89789300
Cholecystitis chronic 14.42 9.90 44 828267 9782 89790354
Cleft palate 14.41 9.90 35 828276 1281 89798855
Skin plaque 14.40 9.90 45 828266 9930 89790206
Pregnancy with contraceptive device 14.40 9.90 15 828296 5051 89795085
Ataxia 14.39 9.90 101 828210 17941 89782195
Device use issue 14.38 9.90 8 828303 3705 89796431
Fracture delayed union 14.37 9.90 53 828258 2453 89797683
Endophthalmitis 14.32 9.90 13 828298 4672 89795464
Nocardiosis 14.32 9.90 3 828308 2567 89797569
Back injury 14.27 9.90 541 827770 46081 89754055
Product residue present 14.24 9.90 11 828300 4280 89795856
Blood phosphorus decreased 14.20 9.90 15 828296 5019 89795117
Hypoalbuminaemia 14.20 9.90 86 828225 15811 89784325
Insomnia 14.19 9.90 2759 825552 330715 89469421
Walking aid user 14.17 9.90 425 827886 35081 89765055
Skin weeping 14.17 9.90 4 828307 2796 89797340
Impaired quality of life 14.17 9.90 139 828172 23005 89777131
Tenosynovitis 14.12 9.90 199 828112 14368 89785768
Lymphatic fistula 14.06 9.90 37 828274 1424 89798712
Ischaemic stroke 14.05 9.90 132 828179 22034 89778102
Uterine perforation 14.04 9.90 30 828281 7524 89792612
Exercise tolerance decreased 14.02 9.90 30 828281 7521 89792615
Device physical property issue 13.98 9.90 4 828307 2772 89797364
Type 1 diabetes mellitus 13.96 9.90 14 828297 4798 89795338
Nasal obstruction 13.95 9.90 54 828257 2558 89797578
Laryngeal oedema 13.93 9.90 26 828285 6855 89793281
Hypoglycaemic coma 13.84 9.90 5 828306 2985 89797151
Loss of employment 13.81 9.90 5 828306 2982 89797154
Activated partial thromboplastin time prolonged 13.78 9.90 32 828279 7793 89792343
Dermatitis acneiform 13.77 9.90 23 828288 6331 89793805
Transaminases increased 13.74 9.90 248 828063 36944 89763192
Product physical issue 13.70 9.90 19 828292 5641 89794495
Pathological fracture 13.65 9.90 44 828267 9616 89790520
Metabolic disorder 13.60 9.90 30 828281 7440 89792696
Disturbance in social behaviour 13.56 9.90 11 828300 4177 89795959
Intracranial pressure increased 13.55 9.90 26 828285 6785 89793351
Dermatitis contact 13.52 9.90 71 828240 13524 89786612
Wound infection pseudomonas 13.52 9.90 45 828266 1978 89798158
Bundle branch block right 13.51 9.90 18 828293 5435 89794701
Drug effective for unapproved indication 13.46 9.90 33 828278 7885 89792251
Folate deficiency 13.44 9.90 61 828250 3104 89797032
Device deployment issue 13.43 9.90 15 828296 4894 89795242
Renal tubular necrosis 13.39 9.90 78 828233 14477 89785659
Brain injury 13.35 9.90 32 828279 7706 89792430
Catheter site erythema 13.34 9.90 15 828296 4879 89795257
Femoral hernia incarcerated 13.32 9.90 37 828274 1471 89798665
Serum ferritin increased 13.27 9.90 114 828197 7267 89792869
Myocardial ischaemia 13.26 9.90 73 828238 13741 89786395
Device malfunction 13.26 9.90 125 828186 20852 89779284
Pelvi-ureteric obstruction 13.19 9.90 17 828294 371 89799765
Reversible cerebral vasoconstriction syndrome 13.18 9.90 11 828300 4119 89796017
Epstein-Barr virus associated lymphoproliferative disorder 13.15 9.90 4 828307 2663 89797473
Bone density increased 13.13 9.90 27 828284 882 89799254
Increased appetite 13.12 9.90 59 828252 11706 89788430
Thirst 13.10 9.90 91 828220 16204 89783932
Spondylitis 13.08 9.90 192 828119 13986 89786150
Hallucinations, mixed 13.06 9.90 21 828290 5868 89794268
Blood lactate dehydrogenase increased 12.99 9.90 163 828148 25769 89774367
Dermatitis exfoliative 12.99 9.90 19 828292 5517 89794619
Reticulocyte count increased 12.94 9.90 30 828281 1065 89799071
Decreased appetite 12.93 9.90 3148 825163 373392 89426744
Fracture 12.87 9.90 278 828033 21798 89778338
Cystitis haemorrhagic 12.86 9.90 19 828292 5494 89794642
Cross sensitivity reaction 12.85 9.90 5 828306 2852 89797284
Hypercapnia 12.84 9.90 26 828285 6651 89793485
Iritis 12.75 9.90 67 828244 3619 89796517
Pulmonary toxicity 12.75 9.90 58 828253 11473 89788663
Implant site pain 12.73 9.90 4 828307 2608 89797528
Heparin-induced thrombocytopenia 12.69 9.90 18 828293 5294 89794842
Major depression 12.64 9.90 48 828263 9987 89790149
Polydipsia 12.63 9.90 12 828299 4219 89795917
Injection site erythema 12.61 9.90 1055 827256 97447 89702689
Cervix haematoma uterine 12.61 9.90 4 828307 3 89800133
Neonatal respiratory distress syndrome 12.60 9.90 59 828252 3042 89797094
Long QT syndrome 12.59 9.90 11 828300 4026 89796110
Terminal state 12.56 9.90 5 828306 2813 89797323
Bundle branch block left 12.53 9.90 34 828277 7851 89792285
Hygroma colli 12.51 9.90 5 828306 12 89800124
Twin pregnancy 12.50 9.90 32 828279 1211 89798925
Productive cough 12.48 9.90 576 827735 76487 89723649
Facial pain 12.47 9.90 70 828241 13112 89787024
Product availability issue 12.47 9.90 31 828280 7373 89792763
Congenital anomaly 12.47 9.90 100 828211 6247 89793889
Inflammatory marker increased 12.46 9.90 134 828177 9080 89791056
Upper-airway cough syndrome 12.43 9.90 84 828227 15051 89785085
Naevus flammeus 12.42 9.90 10 828301 121 89800015
Haematemesis 12.42 9.90 225 828086 33501 89766635
Cervical dysplasia 12.40 9.90 71 828240 3963 89796173
Foetal distress syndrome 12.36 9.90 39 828272 1666 89798470
Induced labour 12.34 9.90 28 828283 980 89799156
Pancreatic steatosis 12.31 9.90 38 828273 1604 89798532
Short stature 12.30 9.90 29 828282 1041 89799095
Persecutory delusion 12.29 9.90 7 828304 3201 89796935
Abortion missed 12.29 9.90 43 828268 1939 89798197
Sensitisation 12.28 9.90 12 828299 4163 89795973
Microcephaly 12.27 9.90 34 828277 1350 89798786
Total lung capacity decreased 12.25 9.90 10 828301 3785 89796351
Liver disorder 12.24 9.90 1277 827034 119992 89680144
Abnormal dreams 12.22 9.90 57 828254 11200 89788936
Gastroschisis 12.20 9.90 17 828294 401 89799735
Threatened labour 12.19 9.90 26 828285 872 89799264
Cushingoid 12.17 9.90 147 828164 10248 89789888
Crohn's disease 12.15 9.90 81 828230 4770 89795366
Eosinophilic granulomatosis with polyangiitis 12.11 9.90 4 828307 2526 89797610
Roseola 12.08 9.90 4 828307 4 89800132
Clostridium difficile infection 12.06 9.90 246 828065 35999 89764137
Drug screen positive 12.00 9.90 10 828301 3747 89796389
Pulmonary function test abnormal 11.98 9.90 5 828306 2734 89797402
Immune-mediated hepatitis 11.90 9.90 6 828305 2938 89797198
Nail injury 11.88 9.90 24 828287 774 89799362
Choking 11.88 9.90 63 828248 11970 89788166
Placental insufficiency 11.86 9.90 38 828273 1637 89798499
Wrong technique in device usage process 11.85 9.90 22 828289 5813 89794323
Incontinence 11.83 9.90 73 828238 13362 89786774
Abortion incomplete 11.82 9.90 7 828304 3133 89797003
Post procedural haemorrhage 11.80 9.90 41 828270 8757 89791379
B-cell lymphoma 11.75 9.90 65 828246 3581 89796555
Cardiac failure chronic 11.72 9.90 21 828290 5625 89794511
Liver function test increased 11.70 9.90 914 827397 83941 89716195
Physical deconditioning 11.67 9.90 3 828308 2232 89797904
Colorectal cancer 11.67 9.90 11 828300 3882 89796254
Confusional state 11.67 9.90 3820 824491 382385 89417751
Lung adenocarcinoma 11.66 9.90 89 828222 5476 89794660
Sickle cell anaemia 11.64 9.90 21 828290 621 89799515
Respiratory disorder 11.63 9.90 479 827832 64337 89735799
Hepatic necrosis 11.61 9.90 26 828285 6412 89793724
Ulcer haemorrhage 11.59 9.90 319 827992 26002 89774134
Lung transplant 11.58 9.90 10 828301 3682 89796454
Micturition urgency 11.55 9.90 58 828253 11175 89788961
Neutrophilia 11.55 9.90 22 828289 5756 89794380
Septic shock 11.52 9.90 640 827671 83520 89716616
International normalised ratio fluctuation 11.50 9.90 7 828304 3086 89797050
Hypoplastic right heart syndrome 11.48 9.90 7 828304 52 89800084
Nervous system disorder 11.48 9.90 134 828177 21459 89778677
Hepatitis 11.47 9.90 772 827539 69967 89730169
Erythema of eyelid 11.43 9.90 8 828303 3275 89796861
Catheter site haemorrhage 11.43 9.90 10 828301 3658 89796478
Blood calcium increased 11.43 9.90 64 828247 11994 89788142
Pneumonia fungal 11.41 9.90 30 828281 7001 89793135
Normal newborn 11.40 9.90 287 828024 23075 89777061
Ageusia 11.40 9.90 93 828218 15983 89784153
Dialysis 11.36 9.90 59 828252 11270 89788866
Device occlusion 11.30 9.90 45 828266 9237 89790899
Mental impairment 11.28 9.90 98 828213 16622 89783514
Neoplasm recurrence 11.27 9.90 8 828303 3251 89796885
Amenorrhoea 11.23 9.90 62 828249 11660 89788476
Benign ovarian tumour 11.17 9.90 18 828293 485 89799651
Cold sweat 11.15 9.90 79 828232 14002 89786134
Product prescribing error 11.14 9.90 201 828110 29944 89770192
Hypochloraemia 11.13 9.90 5 828306 2617 89797519
Hyperreflexia 11.11 9.90 28 828283 6629 89793507
Double ureter 11.11 9.90 3 828308 0 89800136
Skin fissures 11.11 9.90 129 828182 20680 89779456
Congenital skin dimples 11.11 9.90 9 828302 110 89800026
Skin disorder 11.09 9.90 253 828058 36453 89763683
Bronchial secretion retention 11.09 9.90 10 828301 3605 89796531
Depression 11.06 9.90 2505 825806 298096 89502040
Inadequate analgesia 11.04 9.90 8 828303 3216 89796920
Pharyngeal oedema 11.03 9.90 77 828234 13694 89786442
Ingrown hair 11.01 9.90 20 828291 595 89799541
Intraocular pressure increased 10.96 9.90 31 828280 7062 89793074
Facial paralysis 10.95 9.90 90 828221 15444 89784692
Procedural pain 10.93 9.90 227 828084 33133 89767003
Therapy non-responder 10.91 9.90 1418 826893 135286 89664850
Skin swelling 10.90 9.90 28 828283 6586 89793550
Embolism 10.90 9.90 47 828264 9434 89790702
Subacute cutaneous lupus erythematosus 10.88 9.90 10 828301 3572 89796564
Enterocolitis 10.88 9.90 54 828257 10436 89789700
Blood iron increased 10.87 9.90 41 828270 1918 89798218
Hepatitis fulminant 10.85 9.90 12 828299 3933 89796203
Toxoplasma serology positive 10.85 9.90 5 828306 19 89800117
Bradycardia neonatal 10.85 9.90 28 828283 1065 89799071
Oligoarthritis 10.84 9.90 19 828292 549 89799587
Atrial flutter 10.80 9.90 56 828255 10702 89789434
Intentional dose omission 10.80 9.90 107 828204 17676 89782460
Incoherent 10.80 9.90 18 828293 4959 89795177
Eye pain 10.80 9.90 314 827997 43854 89756282
Bacterial infection 10.78 9.90 150 828161 23294 89776842
Congenital tricuspid valve atresia 10.76 9.90 7 828304 59 89800077
Amniotic fluid volume increased 10.76 9.90 11 828300 185 89799951
Tension headache 10.75 9.90 34 828277 7475 89792661
Joint warmth 10.73 9.90 38 828273 1724 89798412
Neuralgia 10.72 9.90 213 828098 31287 89768849
Purpura 10.70 9.90 85 828226 14693 89785443
Scratch 10.69 9.90 50 828261 9816 89790320
Flatulence 10.65 9.90 292 828019 41075 89759061
Bone marrow failure 10.63 9.90 219 828092 32002 89768134
Squamous cell carcinoma 10.62 9.90 140 828171 9961 89790175
Hypokinesia 10.59 9.90 92 828219 15605 89784531
Somnambulism 10.55 9.90 26 828285 6202 89793934
Hepatic encephalopathy 10.55 9.90 78 828233 13694 89786442
Embedded device 10.55 9.90 14 828297 4234 89795902
Hyperpyrexia 10.54 9.90 17 828294 4744 89795392
Oral pain 10.53 9.90 223 828088 32460 89767676
Prothrombin consumption time prolonged 10.49 9.90 6 828305 39 89800097
Hemianopia 10.49 9.90 3 828308 2079 89798057
Cholestasis of pregnancy 10.47 9.90 35 828276 1542 89798594
Human anti-human antibody test 10.45 9.90 16 828295 412 89799724
Therapeutic response unexpected 10.42 9.90 139 828172 21741 89778395
Central nervous system lesion 10.40 9.90 63 828248 11583 89788553
Lordosis 10.34 9.90 14 828297 321 89799815
Breast cancer stage II 10.34 9.90 408 827903 34926 89765210
Poor quality device used 10.33 9.90 4 828307 2289 89797847
Dermatitis 10.28 9.90 142 828169 22078 89778058
Paronychia 10.27 9.90 38 828273 7968 89792168
Cervical incompetence 10.26 9.90 20 828291 628 89799508
Seasonal allergy 10.23 9.90 148 828163 22835 89777301
Incorrect product administration duration 10.23 9.90 120 828191 19202 89780934
Hyperammonaemia 10.23 9.90 28 828283 6447 89793689
Thinking abnormal 10.20 9.90 64 828247 11668 89788468
Bone marrow oedema 10.18 9.90 33 828278 1430 89798706
Loss of proprioception 10.18 9.90 17 828294 472 89799664
Areflexia 10.17 9.90 11 828300 3642 89796494
Kidney transplant rejection 10.14 9.90 18 828293 4839 89795297
Anal prolapse 10.13 9.90 8 828303 94 89800042
Drug abuser 10.12 9.90 6 828305 2684 89797452
Teratoma benign 10.12 9.90 7 828304 66 89800070
Ventricular hypokinesia 10.10 9.90 21 828290 5320 89794816
Hypoplastic left heart syndrome 10.08 9.90 11 828300 200 89799936
Cyst rupture 10.08 9.90 23 828288 808 89799328
Rheumatoid arthritis-associated interstitial lung disease 10.05 9.90 14 828297 330 89799806
Arnold-Chiari malformation 9.99 9.90 21 828290 697 89799439
Lipase increased 9.98 9.90 60 828251 11051 89789085
Ventricular arrhythmia 9.97 9.90 15 828296 4306 89795830
Venoocclusive disease 9.93 9.90 5 828306 2450 89797686
Iron overload 9.91 9.90 26 828285 999 89799137

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Foetal exposure during pregnancy 757.30 10.29 1127 241426 46184 42332598
Rheumatoid arthritis 608.75 10.29 961 241592 41479 42337303
Drug abuse 392.23 10.29 63 242490 104708 42274074
Toxicity to various agents 356.84 10.29 469 242084 228667 42150115
Completed suicide 286 10.29 96 242457 96369 42282413
Psoriatic arthropathy 241.80 10.29 476 242077 24491 42354291
Arthralgia 216.15 10.29 1945 240608 203293 42175489
Dysmorphism 205.21 10.29 162 242391 3154 42375628
Sickle cell anaemia with crisis 191.43 10.29 184 242369 4706 42374076
Small for dates baby 178.22 10.29 183 242370 5080 42373702
Atrial septal defect 169.20 10.29 217 242336 7702 42371080
Drug interaction 155.85 10.29 887 241666 266112 42112670
Premature baby 147.02 10.29 373 242180 22780 42356002
Psoriasis 146.12 10.29 606 241947 47998 42330784
Hypospadias 141.11 10.29 135 242418 3432 42375350
Intentional overdose 141.03 10.29 58 242495 51398 42327384
Joint swelling 124.91 10.29 737 241816 67285 42311497
Death 119.30 10.29 1926 240627 469259 41909523
Congenital umbilical hernia 112.33 10.29 50 242503 306 42378476
Product use in unapproved indication 109.00 10.29 610 241943 183846 42194936
Off label use 107.00 10.29 2793 239760 635542 41743240
Ventricular septal defect 105.93 10.29 128 242425 4271 42374511
Pancytopenia 104.04 10.29 1076 241477 116667 42262115
Speech disorder developmental 102.98 10.29 93 242460 2192 42376590
Musculoskeletal stiffness 100.38 10.29 617 241936 57148 42321634
Cryptorchism 100.33 10.29 87 242466 1940 42376842
Maternal exposure during pregnancy 98.55 10.29 157 242396 6821 42371961
Disease progression 97.36 10.29 453 242100 143203 42235579
Foetal anticonvulsant syndrome 95.02 10.29 68 242485 1134 42377648
Arthritis 93.45 10.29 480 242073 41585 42337197
Synovitis 91.85 10.29 244 242309 15323 42363459
Enthesopathy 90.36 10.29 124 242429 4704 42374078
Neonatal respiratory distress syndrome 89.16 10.29 119 242434 4394 42374388
Respiratory disorder neonatal 88.43 10.29 80 242473 1890 42376892
Hepatic function abnormal 82.69 10.29 103 242450 51464 42327318
Drug ineffective 82.51 10.29 2850 239703 627347 41751435
Blood pressure fluctuation 81.24 10.29 336 242217 26572 42352210
Hypoglycaemia neonatal 80.59 10.29 79 242474 2071 42376711
Low birth weight baby 80.19 10.29 176 242377 9779 42369003
Pain 80.04 10.29 1890 240663 242958 42135824
Serotonin syndrome 79.60 10.29 24 242529 25821 42352961
Exposure during pregnancy 79.17 10.29 160 242393 8388 42370394
Drug dependence 77.78 10.29 34 242519 29060 42349722
Rhabdomyolysis 77.63 10.29 209 242344 77810 42300972
Coma 76.79 10.29 116 242437 53438 42325344
Tenosynovitis 76.68 10.29 113 242440 4582 42374200
Drug resistance 75.57 10.29 51 242502 34197 42344585
Sedation 74.79 10.29 40 242513 30435 42348347
Blood pressure systolic increased 73.54 10.29 335 242218 27633 42351149
Learning disorder 72.39 10.29 56 242497 1057 42377725
Arthropathy 72.31 10.29 347 242206 29250 42349532
Agitation neonatal 72.12 10.29 62 242491 1366 42377416
Febrile neutropenia 69.55 10.29 698 241855 185005 42193777
Maternal drugs affecting foetus 69.45 10.29 97 242456 3742 42375040
Suicide attempt 67.90 10.29 98 242455 46002 42332780
Autism spectrum disorder 67.19 10.29 84 242469 2904 42375878
C-reactive protein abnormal 67.10 10.29 157 242396 9104 42369678
Blood pressure systolic abnormal 66.84 10.29 116 242437 5412 42373370
Intentional product misuse 66.07 10.29 160 242393 61740 42317042
Hypotonia neonatal 64.14 10.29 59 242494 1425 42377357
Overdose 63.81 10.29 345 242208 104919 42273863
Syndactyly 62.72 10.29 48 242505 891 42377891
Foot deformity 59.53 10.29 105 242448 4963 42373819
Talipes 58.70 10.29 68 242485 2168 42376614
Bradycardia neonatal 57.11 10.29 53 242500 1295 42377487
Developmental delay 56.97 10.29 80 242473 3102 42375680
Blood pressure diastolic abnormal 55.92 10.29 114 242439 6014 42372768
Osteoarthritis 54.55 10.29 279 242274 24126 42354656
Palmar-plantar erythrodysaesthesia syndrome 53.54 10.29 25 242528 20557 42358225
Rheumatoid nodule 53.18 10.29 75 242478 2920 42375862
Altered state of consciousness 52.86 10.29 53 242500 29206 42349576
Poisoning 52.42 10.29 10 242543 14689 42364093
Renal aplasia 52.24 10.29 40 242513 743 42378039
Drug withdrawal syndrome neonatal 51.85 10.29 92 242461 4369 42374413
Multiple organ dysfunction syndrome 50.88 10.29 333 242220 96702 42282080
Weight decreased 49.55 10.29 1541 241012 206407 42172375
Drug ineffective for unapproved indication 49.51 10.29 119 242434 46044 42332738
Alanine aminotransferase abnormal 48.74 10.29 95 242458 4849 42373933
Joint effusion 48.34 10.29 105 242448 5792 42372990
Joint laxity 47.90 10.29 30 242523 396 42378386
Neuroleptic malignant syndrome 47.34 10.29 32 242521 21440 42357342
Suicidal ideation 47.16 10.29 130 242423 48031 42330751
Language disorder 46.97 10.29 64 242489 2411 42376371
Foetal growth restriction 46.70 10.29 97 242456 5186 42373596
C-reactive protein increased 46.56 10.29 560 241993 63000 42315782
No adverse event 46.43 10.29 95 242458 38926 42339856
Nasal disorder 46.01 10.29 57 242496 1952 42376830
Angioedema 45.95 10.29 109 242444 42368 42336414
Dysgraphia 45.92 10.29 64 242489 2464 42376318
Pathogen resistance 44.86 10.29 6 242547 11444 42367338
Malignant neoplasm progression 44.57 10.29 398 242155 108002 42270780
Heart rate decreased 44.51 10.29 358 242195 36174 42342608
Haematochezia 44.19 10.29 518 242035 57918 42320864
Maternal exposure during breast feeding 43.72 10.29 49 242504 1506 42377276
Selective eating disorder 43.57 10.29 52 242501 1712 42377070
Pain in extremity 42.44 10.29 1140 241413 149464 42229318
Jaundice neonatal 42.35 10.29 57 242496 2122 42376660
Cleft lip and palate 42.13 10.29 38 242515 894 42377888
Drug reaction with eosinophilia and systemic symptoms 41.62 10.29 113 242440 41962 42336820
Exposure via breast milk 41.01 10.29 60 242493 2417 42376365
Caesarean section 40.79 10.29 55 242498 2051 42376731
Nasopharyngitis 40.28 10.29 687 241866 83309 42295473
Hypertelorism 39.94 10.29 31 242522 588 42378194
Blood pressure diastolic decreased 39.93 10.29 140 242413 10235 42368547
Acute chest syndrome 39.67 10.29 39 242514 1026 42377756
Grip strength decreased 39.16 10.29 72 242481 3516 42375266
Drug use disorder 39.12 10.29 6 242547 10327 42368455
Hyperbilirubinaemia neonatal 38.61 10.29 35 242518 829 42377953
Plagiocephaly 38.52 10.29 30 242523 572 42378210
Large for dates baby 38.32 10.29 36 242517 894 42377888
Myelosuppression 38.29 10.29 111 242442 40350 42338432
Hypertonia neonatal 38.17 10.29 30 242523 580 42378202
Peripheral swelling 37.88 10.29 723 241830 89547 42289235
Bradycardia 37.76 10.29 308 242245 85176 42293606
Haemoglobin decreased 37.67 10.29 1004 241549 131467 42247315
Tongue disorder 37.63 10.29 90 242463 5293 42373489
Cardiac septal defect 37.34 10.29 36 242517 924 42377858
Central nervous system mass 37.11 10.29 34 242519 817 42377965
Wall motion score index abnormal 36.97 10.29 34 242519 821 42377961
Hand deformity 36.66 10.29 72 242481 3696 42375086
Colitis ulcerative 36.64 10.29 265 242288 25910 42352872
Respiratory failure 36.59 10.29 511 242042 127621 42251161
Red blood cell sedimentation rate increased 36.55 10.29 132 242421 9792 42368990
Ear disorder 36.33 10.29 51 242502 1977 42376805
Inflammation 36.11 10.29 322 242231 33525 42345257
Anal fissure 35.99 10.29 87 242466 5152 42373630
Basal cell carcinoma 35.87 10.29 237 242316 22496 42356286
Spina bifida 35.87 10.29 25 242528 399 42378383
Patent ductus arteriosus 35.75 10.29 68 242485 3408 42375374
Acute kidney injury 35.64 10.29 1718 240835 365619 42013163
Birth mark 35.49 10.29 18 242535 153 42378629
Airway remodelling 35.48 10.29 34 242519 866 42377916
Blood pressure diastolic increased 35.38 10.29 98 242455 6307 42372475
Ventricular fibrillation 35.28 10.29 74 242479 30049 42348733
Haemangioma congenital 34.79 10.29 27 242526 512 42378270
Knee arthroplasty 34.23 10.29 119 242434 8662 42370120
Motor developmental delay 34.15 10.29 30 242523 681 42378101
Neurotoxicity 34.12 10.29 51 242502 23600 42355182
Wrong technique in product usage process 34.10 10.29 126 242427 42509 42336273
Appendicolith 34.00 10.29 17 242536 13439 42365343
Respiratory arrest 33.99 10.29 69 242484 28355 42350427
Intellectual disability 33.84 10.29 48 242505 1879 42376903
Body temperature decreased 33.77 10.29 167 242386 14246 42364536
Atopy 33.19 10.29 34 242519 941 42377841
Psychotic disorder 33.17 10.29 73 242480 29135 42349647
Therapy partial responder 33.14 10.29 39 242514 19982 42358800
Acute hepatic failure 33.11 10.29 29 242524 17044 42361738
Agitation 33.05 10.29 222 242331 64092 42314690
Cardiac arrest 32.28 10.29 433 242120 108887 42269895
Pectus excavatum 32.24 10.29 19 242534 223 42378559
Polyarthritis 32.15 10.29 82 242471 5022 42373760
Hypermobility syndrome 32.11 10.29 22 242531 341 42378441
Shock 32.08 10.29 74 242479 29047 42349735
Immune reconstitution inflammatory syndrome 32.00 10.29 9 242544 10134 42368648
BK virus infection 31.27 10.29 6 242547 8778 42370004
Congenital hydronephrosis 31.21 10.29 30 242523 767 42378015
Wound 31.09 10.29 185 242368 16932 42361850
Renal impairment 30.97 10.29 441 242112 109787 42268995
Anaphylactic shock 30.84 10.29 54 242499 23463 42355319
General physical health deterioration 30.66 10.29 1100 241453 150146 42228636
Drug withdrawal syndrome 30.57 10.29 47 242506 21502 42357280
Depressed level of consciousness 30.29 10.29 155 242398 47815 42330967
Pulmonary fibrosis 30.11 10.29 257 242296 26424 42352358
Cardiac murmur 29.92 10.29 148 242405 12627 42366155
Respiratory depression 29.91 10.29 38 242515 18830 42359952
Polydactyly 29.86 10.29 36 242517 1198 42377584
Hydrops foetalis 29.80 10.29 31 242522 874 42377908
Infusion related reaction 29.75 10.29 499 242054 60307 42318475
Low set ears 29.65 10.29 24 242529 485 42378297
Cardiogenic shock 29.38 10.29 104 242449 35536 42343246
Joint range of motion decreased 29.30 10.29 104 242449 7649 42371133
Venoocclusive liver disease 29.23 10.29 11 242542 10291 42368491
Finger deformity 29.11 10.29 41 242512 1594 42377188
Dyspraxia 29.03 10.29 23 242530 450 42378332
Tuberculosis 28.84 10.29 124 242429 9975 42368807
Temperature regulation disorder 28.36 10.29 34 242519 1125 42377657
Abdominal discomfort 28.31 10.29 593 241960 74662 42304120
Congenital hand malformation 28.26 10.29 26 242527 628 42378154
Abnormal palmar/plantar creases 28.24 10.29 17 242536 208 42378574
Microangiopathy 28.22 10.29 41 242512 1641 42377141
Delirium 28.14 10.29 179 242374 52340 42326442
Squamous cell carcinoma of lung 28.14 10.29 48 242505 2208 42376574
Substance abuse 27.91 10.29 8 242545 8897 42369885
Astigmatism 27.69 10.29 36 242517 1295 42377487
Kidney duplex 27.43 10.29 21 242532 390 42378392
Mucormycosis 27.38 10.29 4 242549 7139 42371643
Renal failure 27.36 10.29 616 241937 143110 42235672
Trisomy 18 27.35 10.29 29 242524 836 42377946
Post transplant lymphoproliferative disorder 27.14 10.29 9 242544 9111 42369671
Maternal exposure before pregnancy 27.02 10.29 32 242521 1045 42377737
Mucocutaneous ulceration 27.01 10.29 23 242530 500 42378282
Cytomegalovirus infection 26.81 10.29 94 242459 32212 42346570
Akathisia 26.71 10.29 13 242540 10438 42368344
Hepatic failure 26.45 10.29 119 242434 37981 42340801
Musculoskeletal pain 26.30 10.29 298 242255 33042 42345740
Ear infection 26.29 10.29 143 242410 12661 42366121
Knee deformity 26.22 10.29 27 242526 752 42378030
Electrocardiogram QT prolonged 25.90 10.29 163 242390 47782 42331000
Catarrh 25.88 10.29 84 242469 5902 42372880
Anal fistula 25.80 10.29 86 242467 6127 42372655
Congenital tricuspid valve incompetence 25.67 10.29 14 242539 140 42378642
Cytomegalovirus infection reactivation 25.53 10.29 16 242537 11162 42367620
Foetal disorder 25.33 10.29 31 242522 1048 42377734
Eosinophilic myocarditis 25.30 10.29 35 242518 1338 42377444
Ankylosing spondylitis 25.27 10.29 93 242460 6963 42371819
Blood pressure increased 25.20 10.29 759 241794 101169 42277613
Constipation 25.14 10.29 717 241836 161574 42217208
Single umbilical artery 25.05 10.29 16 242537 219 42378563
Congenital knee deformity 25.00 10.29 13 242540 117 42378665
Aspergillus infection 25.00 10.29 32 242521 15805 42362977
Suspected suicide 24.89 10.29 3 242550 6196 42372586
Tendonitis 24.89 10.29 117 242436 9777 42369005
Haematocrit decreased 24.87 10.29 306 242247 34602 42344180
Accidental exposure to product 24.81 10.29 49 242504 20344 42358438
Blood creatine phosphokinase increased 24.76 10.29 167 242386 48171 42330611
Toxic epidermal necrolysis 24.15 10.29 75 242478 26675 42352107
Therapeutic product effect decreased 24.05 10.29 334 242219 38816 42339966
Lower respiratory tract infection 23.90 10.29 348 242205 40858 42337924
Bronchiolitis 23.83 10.29 62 242491 3844 42374938
Hyperglycaemia 23.71 10.29 158 242395 45701 42333081
Hypoglycaemia 23.61 10.29 222 242331 59632 42319150
Ultrasound antenatal screen 23.56 10.29 22 242531 542 42378240
Adenovirus infection 23.51 10.29 5 242548 6804 42371978
Diaphragmatic disorder 23.45 10.29 32 242521 1207 42377575
Somnolence 23.24 10.29 618 241935 140487 42238295
Cytokine release syndrome 23.23 10.29 153 242400 44374 42334408
Tachycardia 23.20 10.29 420 242133 100667 42278115
Nodule 23.11 10.29 136 242417 12398 42366384
Educational problem 23.10 10.29 22 242531 556 42378226
Psychomotor retardation 23.02 10.29 66 242487 4333 42374449
Frequent bowel movements 23.01 10.29 204 242349 21203 42357579
Vitamin D deficiency 22.95 10.29 99 242454 7974 42370808
Syringe issue 22.87 10.29 10 242543 8546 42370236
Pruritus 22.82 10.29 861 241692 187910 42190872
Developmental coordination disorder 22.66 10.29 15 242538 219 42378563
Ankyloglossia congenital 22.39 10.29 18 242535 360 42378422
Burns second degree 22.38 10.29 81 242472 6015 42372767
Cystitis haemorrhagic 22.22 10.29 7 242546 7322 42371460
Skin cancer 22.19 10.29 126 242427 11336 42367446
Bursitis 22.11 10.29 82 242471 6162 42372620
Urticaria 21.93 10.29 293 242260 73743 42305039
Polyomavirus-associated nephropathy 21.86 10.29 3 242550 5612 42373170
Weight decrease neonatal 21.84 10.29 17 242536 324 42378458
Strabismus 21.80 10.29 44 242509 2304 42376478
Medical device implantation 21.76 10.29 22 242531 599 42378183
Intentional self-injury 21.71 10.29 33 242520 15169 42363613
Ectopic kidney 21.52 10.29 8 242545 28 42378754
Lung neoplasm malignant 21.38 10.29 184 242369 18963 42359819
Immunosuppression 21.29 10.29 100 242453 8353 42370429
Hydrocele 21.18 10.29 46 242507 2537 42376245
Systemic lupus erythematosus 21.12 10.29 107 242446 9217 42369565
Cardiotoxicity 21.04 10.29 8 242545 7437 42371345
Drug dose omission by device 21.00 10.29 4 242549 5882 42372900
Otitis media 20.99 10.29 57 242496 3626 42375156
Arthritis infective 20.90 10.29 61 242492 4045 42374737
Serum ferritin increased 20.89 10.29 89 242464 7130 42371652
Fine motor skill dysfunction 20.84 10.29 42 242511 2197 42376585
Neonatal seizure 20.72 10.29 20 242533 514 42378268
Attention deficit hyperactivity disorder 20.70 10.29 51 242502 3057 42375725
Dyslexia 20.69 10.29 17 242536 351 42378431
Clinodactyly 20.62 10.29 15 242538 257 42378525
Microcephaly 20.59 10.29 26 242527 908 42377874
Congenital myopia 20.55 10.29 10 242543 77 42378705
Sopor 20.50 10.29 27 242526 13175 42365607
Joint stiffness 20.38 10.29 130 242423 12192 42366590
Vitamin B12 deficiency 20.33 10.29 68 242485 4854 42373928
Loss of personal independence in daily activities 20.21 10.29 397 242156 49419 42329363
Congenital foot malformation 20.05 10.29 18 242535 421 42378361
Eosinophil count decreased 20.04 10.29 55 242498 3521 42375261
Multiple congenital abnormalities 19.92 10.29 20 242533 540 42378242
Crohn's disease 19.91 10.29 49 242504 2935 42375847
Prognathism 19.75 10.29 11 242542 115 42378667
Radiation inflammation 19.74 10.29 27 242526 1021 42377761
Congenital astigmatism 19.71 10.29 9 242544 59 42378723
Umbilical hernia 19.68 10.29 72 242481 5375 42373407
Cytomegalovirus viraemia 19.67 10.29 18 242535 10359 42368423
Fall 19.58 10.29 1569 240984 232951 42145831
Congenital anomaly 19.50 10.29 33 242520 1508 42377274
Hypokalaemia 19.42 10.29 289 242264 71432 42307350
Parosmia 19.38 10.29 91 242462 7600 42371182
Arthrodesis 19.30 10.29 20 242533 561 42378221
Hypermetropia 19.29 10.29 19 242534 501 42378281
Rebound effect 19.13 10.29 9 242544 7370 42371412
Drug intolerance 19.10 10.29 596 241957 79828 42298954
Pulmonary artery stenosis congenital 18.99 10.29 19 242534 511 42378271
Cardiac failure 18.93 10.29 463 242090 106393 42272389
Asphyxia 18.91 10.29 12 242541 8314 42370468
Localised infection 18.82 10.29 188 242365 20185 42358597
Thymus disorder 18.80 10.29 14 242539 249 42378533
Bronchial carcinoma 18.79 10.29 26 242527 994 42377788
Exposure to toxic agent 18.73 10.29 3 242550 5001 42373781
Sleep disorder due to a general medical condition 18.70 10.29 45 242508 17408 42361374
Lower respiratory tract congestion 18.60 10.29 33 242520 1567 42377215
Spinal disorder 18.58 10.29 63 242490 4528 42374254
Kinematic imbalances due to suboccipital strain 18.52 10.29 6 242547 12 42378770
Vomiting 18.47 10.29 1409 241144 288314 42090468
Appendicitis 18.46 10.29 58 242495 20555 42358227
Scoliosis 18.44 10.29 49 242504 3077 42375705
Strabismus congenital 18.31 10.29 7 242546 27 42378755
Electrocardiogram T wave alternans 18.25 10.29 10 242543 101 42378681
Oesophageal fibrosis 18.20 10.29 12 242541 174 42378608
Device leakage 18.16 10.29 19 242534 10266 42368516
Neoplasm progression 18.14 10.29 94 242459 28906 42349876
Diffuse large B-cell lymphoma recurrent 18.13 10.29 3 242550 4883 42373899
Transient aphasia 17.99 10.29 20 242533 609 42378173
Sexual dysfunction 17.98 10.29 8 242545 6767 42372015
Limb reduction defect 17.97 10.29 15 242538 317 42378465
Congenital bladder anomaly 17.93 10.29 14 242539 268 42378514
Tooth malformation 17.91 10.29 12 242541 179 42378603
Spondyloarthropathy 17.90 10.29 24 242529 890 42377892
Folate deficiency 17.86 10.29 34 242519 1705 42377077
Obsessive-compulsive disorder 17.83 10.29 8 242545 6735 42372047
Cleft palate 17.73 10.29 20 242533 619 42378163
Haemolysis 17.65 10.29 104 242449 9485 42369297
Dermatitis atopic 17.65 10.29 27 242526 12377 42366405
Pyloric stenosis 17.62 10.29 24 242529 904 42377878
Pyelocaliectasis 17.60 10.29 30 242523 1379 42377403
Foetal heart rate deceleration abnormality 17.58 10.29 19 242534 560 42378222
Glycosylated haemoglobin increased 17.56 10.29 29 242524 12895 42365887
Gingival pain 17.53 10.29 95 242458 8399 42370383
Behaviour disorder 17.44 10.29 83 242470 6971 42371811
Kyphosis congenital 17.44 10.29 5 242548 5 42378777
Post procedural infection 17.27 10.29 72 242481 5713 42373069
Proteinuria 17.04 10.29 70 242483 22913 42355869
Camptodactyly congenital 16.92 10.29 10 242543 118 42378664
Unresponsive to stimuli 16.84 10.29 107 242446 31296 42347486
Exposure via skin contact 16.79 10.29 4 242549 5034 42373748
Colorectal cancer 16.79 10.29 4 242549 5034 42373748
Epispadias 16.77 10.29 11 242542 158 42378624
Cytomegalovirus chorioretinitis 16.74 10.29 3 242550 4608 42374174
Withdrawal syndrome 16.72 10.29 37 242516 14738 42364044
Potentiating drug interaction 16.60 10.29 8 242545 6460 42372322
Hepatitis B reactivation 16.57 10.29 3 242550 4575 42374207
Psychomotor skills impaired 16.51 10.29 66 242487 5138 42373644
Latent tuberculosis 16.42 10.29 32 242521 1633 42377149
Loss of consciousness 16.40 10.29 400 242153 91954 42286828
Neck mass 16.39 10.29 34 242519 1816 42376966
Synovial cyst 16.32 10.29 42 242511 2587 42376195
Transfusion-related circulatory overload 16.31 10.29 21 242532 748 42378034
Intervertebral disc degeneration 16.30 10.29 84 242469 7283 42371499
Joint ankylosis 16.26 10.29 32 242521 1645 42377137
Red blood cell sedimentation rate 16.22 10.29 25 242528 1055 42377727
Incorrect route of product administration 16.22 10.29 77 242476 24228 42354554
Fine motor delay 16.17 10.29 13 242540 260 42378522
Hallucination 16.17 10.29 230 242323 57277 42321505
Euglycaemic diabetic ketoacidosis 16.13 10.29 6 242547 5654 42373128
Accessory spleen 16.10 10.29 10 242543 130 42378652
Prominent epicanthal folds 16.08 10.29 11 242542 170 42378612
Aggression 16.08 10.29 167 242386 43996 42334786
Cleft lip 16.08 10.29 14 242539 314 42378468
Oxygen saturation decreased 16.06 10.29 482 242071 64205 42314577
Granuloma skin 16.00 10.29 26 242527 1149 42377633
Kyphosis 15.99 10.29 28 242525 1316 42377466
Cholelithiasis 15.92 10.29 203 242350 23143 42355639
Acute graft versus host disease 15.87 10.29 14 242539 8201 42370581
Lacrimal disorder 15.86 10.29 14 242539 320 42378462
Endophthalmitis 15.84 10.29 3 242550 4430 42374352
Steroid dependence 15.83 10.29 78 242475 6644 42372138
Fistula discharge 15.74 10.29 25 242528 1083 42377699
Hepatic steatosis 15.71 10.29 189 242364 21259 42357523
Encopresis 15.70 10.29 11 242542 177 42378605
Blood parathyroid hormone decreased 15.51 10.29 31 242522 1612 42377170
Rhinitis 15.48 10.29 119 242434 11858 42366924
Malignant melanoma 15.44 10.29 99 242454 9301 42369481
Abortion spontaneous 15.43 10.29 15 242538 389 42378393
Ear malformation 15.22 10.29 14 242539 338 42378444
Arthritis bacterial 15.21 10.29 70 242483 5798 42372984
Tumour lysis syndrome 15.09 10.29 70 242483 22161 42356621
Floppy infant 15.05 10.29 10 242543 147 42378635
Diverticular perforation 15.05 10.29 51 242502 3665 42375117
Visuospatial deficit 14.96 10.29 9 242544 110 42378672
Product quality issue 14.86 10.29 52 242501 17830 42360952
Hypopnoea 14.84 10.29 86 242467 7796 42370986
Neutropenia neonatal 14.82 10.29 22 242531 898 42377884
Microphthalmos 14.75 10.29 11 242542 196 42378586
Multiple-drug resistance 14.73 10.29 12 242541 7310 42371472
Inguinal hernia 14.72 10.29 94 242459 8818 42369964
Drug level increased 14.71 10.29 88 242465 26112 42352670
Nephropathy toxic 14.65 10.29 48 242505 16790 42361992
Gross motor delay 14.60 10.29 14 242539 357 42378425
Hospitalisation 14.58 10.29 317 242236 74013 42304769
Heart disease congenital 14.57 10.29 28 242525 1414 42377368
Lactic acidosis 14.56 10.29 176 242377 45085 42333697
Anti-cyclic citrullinated peptide antibody positive 14.50 10.29 33 242520 1879 42376903
Hyperammonaemia 14.49 10.29 14 242539 7852 42370930
Dystonia 14.49 10.29 32 242521 12758 42366024
Micropenis 14.49 10.29 7 242546 53 42378729
Craniosynostosis 14.47 10.29 15 242538 421 42378361
Paranoia 14.38 10.29 37 242516 13989 42364793
Infective pulmonary exacerbation of cystic fibrosis 14.31 10.29 14 242539 7804 42370978
Cardio-respiratory arrest 14.28 10.29 241 242312 58395 42320387
Neuropathy peripheral 14.27 10.29 456 242097 101397 42277385
Enuresis 14.16 10.29 41 242512 2707 42376075
Chronic sinusitis 14.13 10.29 47 242506 3345 42375437
Bronchitis 14.05 10.29 360 242193 46841 42331941
Lung cancer metastatic 13.92 10.29 43 242510 2943 42375839
Sinusitis 13.87 10.29 360 242193 46932 42331850
Poikiloderma 13.83 10.29 13 242540 323 42378459
Heart rate irregular 13.82 10.29 146 242407 15904 42362878
Haemodynamic instability 13.76 10.29 32 242521 12525 42366257
Septic arthritis staphylococcal 13.74 10.29 16 242537 513 42378269
Haematotoxicity 13.71 10.29 26 242527 10959 42367823
Seizure 13.66 10.29 554 241999 120007 42258775
Ventricular tachycardia 13.61 10.29 108 242445 30052 42348730
Pharyngitis 13.61 10.29 92 242461 8798 42369984
Hypoxia 13.58 10.29 298 242255 69488 42309294
Abnormal labour affecting foetus 13.56 10.29 5 242548 17 42378765
Brain stem auditory evoked response abnormal 13.56 10.29 5 242548 17 42378765
Aphthous ulcer 13.56 10.29 68 242485 5833 42372949
Disseminated intravascular coagulation 13.54 10.29 84 242469 24710 42354072
Disease recurrence 13.52 10.29 106 242447 29572 42349210
Cellulitis 13.48 10.29 452 242101 61133 42317649
Communication disorder 13.46 10.29 41 242512 2784 42375998
Carcinoid tumour of the small bowel 13.45 10.29 14 242539 395 42378387
Pseudolymphoma 13.44 10.29 18 242535 667 42378115
Drug-induced liver injury 13.42 10.29 146 242407 38127 42340655
Coarctation of the aorta 13.41 10.29 15 242538 460 42378322
Fatigue 13.40 10.29 2740 239813 432901 41945881
Asymptomatic bacteriuria 13.39 10.29 11 242542 227 42378555
Anal atresia 13.39 10.29 12 242541 280 42378502
Aorticopulmonary septal defect 13.35 10.29 5 242548 18 42378764
Hernia pain 13.21 10.29 12 242541 285 42378497
Disability assessment scale score increased 13.19 10.29 14 242539 404 42378378
Oropharyngeal pain 13.18 10.29 326 242227 42184 42336598
Pulmonary valve stenosis congenital 13.16 10.29 9 242544 139 42378643
Complications of transplanted kidney 13.16 10.29 7 242546 5343 42373439
C-reactive protein decreased 13.14 10.29 35 242518 2201 42376581
Mania 13.13 10.29 25 242528 10522 42368260
Bone cyst 13.08 10.29 29 242524 1622 42377160
Red blood cell count decreased 13.02 10.29 260 242293 32455 42346327
Myopia 12.96 10.29 25 242528 1266 42377516
Anaemia vitamin B12 deficiency 12.94 10.29 16 242537 547 42378235
Back disorder 12.88 10.29 80 242473 7434 42371348
Blood phosphorus increased 12.87 10.29 33 242520 12492 42366290
Psychiatric decompensation 12.86 10.29 4 242549 4218 42374564
Congenital megaureter 12.84 10.29 9 242544 145 42378637
Peritoneal tuberculosis 12.83 10.29 13 242540 355 42378427
Pulmonary pain 12.82 10.29 28 242525 1550 42377232
Scleroderma renal crisis 12.81 10.29 14 242539 418 42378364
Dry throat 12.80 10.29 41 242512 2861 42375921
Intestinal stenosis 12.72 10.29 40 242513 2764 42376018
Patient isolation 12.69 10.29 6 242547 43 42378739
Sacroiliitis 12.65 10.29 32 242521 1950 42376832
Micrognathia 12.64 10.29 12 242541 302 42378480
Pulmonary valve stenosis 12.60 10.29 14 242539 426 42378356
Alcohol poisoning 12.58 10.29 80 242473 7494 42371288
Cerebral haemorrhage neonatal 12.58 10.29 12 242541 304 42378478
Poor sucking reflex 12.57 10.29 13 242540 364 42378418
Graft versus host disease 12.56 10.29 35 242518 12890 42365892
Umbilical granuloma 12.52 10.29 3 242550 0 42378782
Ectrodactyly 12.52 10.29 3 242550 0 42378782
Hernia congenital 12.52 10.29 3 242550 0 42378782
Nocardiosis 12.46 10.29 7 242546 5183 42373599
Red blood cell sedimentation rate abnormal 12.45 10.29 49 242504 3787 42374995
Haptoglobin decreased 12.43 10.29 18 242535 718 42378064
Electrocardiogram QRS complex prolonged 12.41 10.29 9 242544 5814 42372968
Autoscopy 12.40 10.29 11 242542 253 42378529
Reticulocyte count increased 12.40 10.29 19 242534 798 42377984
Osteonecrosis of jaw 12.34 10.29 61 242492 18988 42359794
Gastrointestinal infection 12.32 10.29 73 242480 6670 42372112
Juvenile idiopathic arthritis 12.30 10.29 38 242515 2601 42376181
Hepatitis E antibody positive 12.30 10.29 11 242542 256 42378526
Congenital genital malformation 12.28 10.29 9 242544 156 42378626
Skin injury 12.28 10.29 38 242515 2603 42376179
Diabetes insipidus 12.28 10.29 3 242550 3710 42375072
Oesophageal adenocarcinoma 12.26 10.29 21 242532 969 42377813
Arnold-Chiari malformation 12.26 10.29 13 242540 375 42378407
Dermatitis psoriasiform 12.25 10.29 33 242520 2089 42376693
Gangrene neonatal 12.23 10.29 10 242543 205 42378577
Ascites 12.22 10.29 238 242315 56440 42322342
Blister infected 12.21 10.29 15 242538 509 42378273
Maternal exposure timing unspecified 12.20 10.29 13 242540 377 42378405
Cystitis bacterial 12.19 10.29 10 242543 206 42378576
Peritoneal dialysis complication 12.18 10.29 31 242522 1896 42376886
Learning disability 12.17 10.29 13 242540 378 42378404
Diverticulum 12.13 10.29 79 242474 7462 42371320
Immunodeficiency 12.11 10.29 77 242476 7213 42371569
Oesophageal atresia 12.10 10.29 15 242538 514 42378268
Upper respiratory tract infection 12.07 10.29 320 242233 41853 42336929
Tardive dyskinesia 11.99 10.29 13 242540 6911 42371871
Foetal distress syndrome 11.95 10.29 23 242530 1163 42377619
Brain oedema 11.94 10.29 50 242503 16277 42362505
Congenital skin dimples 11.91 10.29 10 242543 213 42378569
Congenital scoliosis 11.90 10.29 8 242545 120 42378662
Pleural fibrosis 11.88 10.29 25 242528 1349 42377433
Contusion 11.85 10.29 318 242235 41667 42337115
Mean cell volume increased 11.85 10.29 49 242504 3874 42374908
Pneumonia aspiration 11.82 10.29 207 242346 49871 42328911
Concomitant disease aggravated 11.82 10.29 12 242541 6574 42372208
Developmental hip dysplasia 11.80 10.29 12 242541 329 42378453
Ligament rupture 11.80 10.29 25 242528 1355 42377427
Thinking abnormal 11.80 10.29 14 242539 7147 42371635
Congenital cerebral cyst 11.75 10.29 5 242548 27 42378755
Joint contracture 11.68 10.29 33 242520 2148 42376634
Stevens-Johnson syndrome 11.67 10.29 76 242477 22102 42356680
Myalgia 11.64 10.29 438 242115 95642 42283140
Mydriasis 11.62 10.29 20 242533 8750 42370032
Hypotelorism of orbit 11.62 10.29 8 242545 125 42378657
Thrombotic microangiopathy 11.61 10.29 44 242509 14738 42364044
Meconium in amniotic fluid 11.60 10.29 5 242548 28 42378754
Ligament laxity 11.60 10.29 5 242548 28 42378754
Haemangioma 11.59 10.29 31 242522 1954 42376828
Diabetic ketoacidosis 11.59 10.29 77 242476 22290 42356492
Extrapyramidal disorder 11.55 10.29 51 242502 16361 42362421
Posterior reversible encephalopathy syndrome 11.53 10.29 36 242517 12785 42365997
Cerebral ventricle dilatation 11.53 10.29 21 242532 1018 42377764
Hypotonia 11.52 10.29 93 242460 9406 42369376
Dysphonia 11.44 10.29 105 242448 28345 42350437
Myoclonus 11.43 10.29 54 242499 17011 42361771
Adenomatous polyposis coli 11.41 10.29 9 242544 175 42378607
Muscle twitching 11.38 10.29 32 242521 11748 42367034
Facial pain 11.35 10.29 5 242548 4255 42374527
Neonatal respiratory distress 11.34 10.29 20 242533 945 42377837
Hepatic enzyme increased 11.32 10.29 341 242212 45443 42333339
Disinhibition 11.32 10.29 4 242549 3891 42374891
Anti-erythropoietin antibody positive 11.31 10.29 19 242534 863 42377919
Anaphylactic reaction 11.30 10.29 173 242380 42570 42336212
Palmoplantar pustulosis 11.27 10.29 14 242539 481 42378301
Lung opacity 11.21 10.29 10 242543 5827 42372955
Reticulocytosis 11.20 10.29 11 242542 289 42378493
Graft versus host disease in skin 11.18 10.29 8 242545 5204 42373578
Prostate cancer 11.17 10.29 333 242220 44310 42334472
Dysstasia 11.15 10.29 126 242427 13960 42364822
Hepatic cyst 11.15 10.29 40 242513 2958 42375824
Vascular insufficiency 11.12 10.29 12 242541 353 42378429
Enterocolitis 11.12 10.29 25 242528 9904 42368878
Congenital mitral valve incompetence 11.10 10.29 8 242545 135 42378647
Skin ulcer 11.05 10.29 206 242347 25395 42353387
Pneumonia 11.03 10.29 2635 239918 419514 41959268
Hypocalcaemia 11.02 10.29 114 242439 30059 42348723
Blood insulin increased 11.02 10.29 12 242541 357 42378425
Fistula 11.01 10.29 80 242473 7832 42370950
Placental insufficiency 11.01 10.29 7 242546 95 42378687
Hand fracture 11.00 10.29 39 242514 2867 42375915
Meningeal disorder 10.99 10.29 12 242541 358 42378424
Transplant rejection 10.96 10.29 40 242513 13548 42365234
Weight increased 10.96 10.29 734 241819 107249 42271533
Hepatitis E virus test positive 10.96 10.29 11 242542 297 42378485
Adrenal insufficiency 10.92 10.29 63 242490 18861 42359921
Abnormal behaviour 10.91 10.29 97 242456 26354 42352428
Infection 10.89 10.29 759 241794 111309 42267473
Influenza 10.87 10.29 445 242108 61730 42317052
Live birth 10.86 10.29 10 242543 242 42378540
Pharyngeal disorder 10.85 10.29 19 242534 893 42377889
Emphysema 10.83 10.29 109 242444 11726 42367056
Mutism 10.83 10.29 25 242528 1437 42377345
Neck pain 10.79 10.29 235 242318 29779 42349003
Personal relationship issue 10.78 10.29 11 242542 303 42378479
Cardiac dysfunction 10.75 10.29 3 242550 3396 42375386
High arched palate 10.75 10.29 6 242547 63 42378719
Muscle rigidity 10.75 10.29 34 242519 12025 42366757
Palindromic rheumatism 10.75 10.29 9 242544 191 42378591
Fracture 10.75 10.29 81 242472 8022 42370760
Hypotension 10.71 10.29 1293 241260 256338 42122444
Lip swelling 10.69 10.29 64 242489 18989 42359793
Respiratory rate increased 10.67 10.29 103 242450 10959 42367823
Rheumatoid lung 10.67 10.29 19 242534 905 42377877
Respiratory tract infection viral 10.65 10.29 43 242510 3363 42375419
Anuria 10.65 10.29 32 242521 11500 42367282
Blood folate increased 10.60 10.29 11 242542 309 42378473
Rectal haemorrhage 10.58 10.29 363 242190 49243 42329539
Autosomal chromosome anomaly 10.55 10.29 4 242549 15 42378767
Cerebral haemorrhage 10.55 10.29 157 242396 38809 42339973
Neurodevelopmental disorder 10.50 10.29 13 242540 445 42378337
Nail bed bleeding 10.50 10.29 13 242540 445 42378337
Congenital cystic kidney disease 10.50 10.29 13 242540 445 42378337
Acute respiratory distress syndrome 10.49 10.29 115 242438 29993 42348789
Foetal hypokinesia 10.47 10.29 12 242541 378 42378404
Urinary tract malformation 10.46 10.29 3 242550 3 42378779
Congenital spinal cord anomaly 10.46 10.29 3 242550 3 42378779
Flail chest 10.46 10.29 3 242550 3 42378779
PCO2 decreased 10.46 10.29 28 242525 1766 42377016
Dermal cyst 10.43 10.29 30 242523 1973 42376809
Ventricular dysfunction 10.42 10.29 52 242501 4451 42374331
Dry skin 10.41 10.29 203 242350 48135 42330647
Muscle tone disorder 10.40 10.29 9 242544 200 42378582
Fever neonatal 10.39 10.29 8 242545 150 42378632
Procalcitonin abnormal 10.35 10.29 12 242541 383 42378399

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1281.51 9.93 171 847946 242210 109498972
Toxicity to various agents 1237.71 9.93 1118 846999 479437 109261745
Systemic lupus erythematosus 1058.56 9.93 4307 843810 250031 109491151
Arthropathy 1003.46 9.93 4617 843500 282905 109458277
Pemphigus 995.25 9.93 3760 844357 210810 109530372
Hand deformity 977.36 9.93 3785 844332 214721 109526461
Synovitis 970.31 9.93 4420 843697 269672 109471510
Glossodynia 898.76 9.93 3728 844389 218276 109522906
Joint swelling 895.97 9.93 6139 841978 436706 109304476
Drug abuse 839.92 9.93 169 847948 177242 109563940
Rheumatoid arthritis 787.84 9.93 4444 843673 295169 109446013
Maternal exposure during pregnancy 756.36 9.93 3908 844209 250975 109490207
Wound 755.22 9.93 3679 844438 230758 109510424
Anti-cyclic citrullinated peptide antibody positive 753.78 9.93 3078 845039 178906 109562276
Pericarditis 714.70 9.93 3451 844666 215663 109525519
Infusion related reaction 647.26 9.93 5069 843048 376093 109365089
Duodenal ulcer perforation 632.39 9.93 2871 845246 174829 109566353
Helicobacter infection 609.28 9.93 2887 845230 178990 109562192
Arthralgia 607.30 9.93 8857 839260 770775 108970407
Abdominal discomfort 602.96 9.93 5116 843001 388742 109352440
Death 596.20 9.93 3045 845072 695824 109045358
Swelling 595.13 9.93 4667 843450 346374 109394808
Intentional overdose 587.34 9.93 146 847971 132355 109608827
Drug interaction 565.99 9.93 1954 846163 498229 109242953
Alopecia 548.24 9.93 4719 843398 360034 109381148
Therapeutic product effect decreased 538.64 9.93 3462 844655 240854 109500328
Psoriatic arthropathy 537.81 9.93 2950 845167 193811 109547371
Pain 509.64 9.93 10206 837911 944749 108796433
Febrile neutropenia 494.65 9.93 1056 847061 315711 109425471
Discomfort 484.69 9.93 3061 845056 211646 109529536
Rheumatoid factor positive 475.08 9.93 2136 845981 129504 109611678
Musculoskeletal stiffness 447.74 9.93 3672 844445 276150 109465032
Impaired healing 444.91 9.93 2806 845311 193911 109547271
Contraindicated product administered 431.71 9.93 3321 844796 244946 109496236
Hepatic enzyme increased 419.59 9.93 4029 844088 316863 109424319
Exposure during pregnancy 410.04 9.93 2438 845679 164986 109576196
Folliculitis 393.82 9.93 2415 845702 165238 109575944
Disease progression 376.33 9.93 819 847298 243215 109497967
Nasopharyngitis 371.02 9.93 4638 843479 389723 109351459
Irritable bowel syndrome 366.68 9.93 2335 845782 161880 109579302
Muscle injury 357.43 9.93 2070 846047 138737 109602445
C-reactive protein abnormal 347.87 9.93 1935 846182 127760 109613422
Blister 341.93 9.93 2943 845174 224433 109516749
Suicide attempt 338.91 9.93 185 847932 103209 109637973
Fibromyalgia 329.30 9.93 2343 845774 168566 109572616
Lower respiratory tract infection 318.92 9.93 3055 845062 240051 109501131
Malignant neoplasm progression 317.11 9.93 531 847586 174036 109567146
Rheumatic fever 316.96 9.93 1811 846306 120768 109620414
Acute kidney injury 313.09 9.93 3238 844879 632192 109108990
Drug intolerance 310.63 9.93 4606 843511 401906 109339276
Cardiac arrest 309.41 9.93 653 847464 196100 109545082
Depressed level of consciousness 308.35 9.93 245 847872 112033 109629149
Osteoarthritis 304.12 9.93 2419 845698 180204 109560978
Sleep disorder due to general medical condition, insomnia type 300.71 9.93 1602 846515 104041 109637141
Sedation 278.90 9.93 93 848024 69590 109671592
Sickle cell anaemia with crisis 272.47 9.93 351 847766 9194 109731988
Ill-defined disorder 270.70 9.93 2095 846022 154758 109586424
Peripheral swelling 260.75 9.93 4451 843666 399583 109341599
Sinusitis 259.29 9.93 3443 844674 293245 109447937
Rhabdomyolysis 253.00 9.93 331 847786 120070 109621112
Stomatitis 247.83 9.93 3164 844953 267078 109474104
Overdose 247.70 9.93 938 847179 232856 109508326
Inflammation 246.80 9.93 2415 845702 190823 109550359
Type 2 diabetes mellitus 241.22 9.93 2245 845872 174987 109566195
Swollen joint count increased 239.00 9.93 1270 846847 82391 109658791
Hypersensitivity 234.57 9.93 4377 843740 399621 109341561
Neutropenia 227.85 9.93 1809 846308 372811 109368371
Weight increased 224.43 9.93 4490 843627 415154 109326028
Constipation 220.24 9.93 1722 846395 356064 109385118
Bradycardia 218.75 9.93 548 847569 154969 109586213
Myelosuppression 215.51 9.93 243 847874 94097 109647085
Respiratory failure 214.69 9.93 885 847232 214447 109526735
Multiple organ dysfunction syndrome 213.85 9.93 534 847583 151176 109590006
Drug resistance 212.43 9.93 83 848034 56291 109684891
Drug ineffective for unapproved indication 210.69 9.93 288 847829 102550 109638632
Joint range of motion decreased 209.49 9.93 1626 846491 120206 109620976
Hepatic function abnormal 206.18 9.93 228 847889 89067 109652115
Serotonin syndrome 205.55 9.93 98 848019 59055 109682127
Facet joint syndrome 205.15 9.93 1359 846758 95469 109645713
Contusion 204.60 9.93 2710 845407 230651 109510531
Hypotension 197.79 9.93 2827 845290 521022 109220160
Gestational diabetes 197.39 9.93 263 847854 7126 109734056
Red blood cell sedimentation rate abnormal 195.14 9.93 518 847599 23991 109717191
Coma 193.07 9.93 382 847735 117487 109623695
Treatment failure 192.68 9.93 3092 845025 274142 109467040
Drug reaction with eosinophilia and systemic symptoms 192.44 9.93 207 847910 81888 109659294
Electrocardiogram QT prolonged 190.93 9.93 339 847778 108621 109632561
Somnolence 188.95 9.93 1419 846698 296030 109445152
Lactic acidosis 188.05 9.93 262 847855 92549 109648633
Hyperhidrosis 186.56 9.93 770 847347 186528 109554654
Renal failure 186.53 9.93 998 847119 225576 109515606
Respiratory arrest 182.91 9.93 110 848007 58189 109682993
Lip dry 182.31 9.93 1354 846763 98729 109642453
Pregnancy 182.16 9.93 826 847291 50241 109690941
Knee arthroplasty 181.46 9.93 980 847137 63968 109677214
Agitation 181.22 9.93 371 847746 112680 109628502
Cardiac failure 180.32 9.93 782 847335 186844 109554338
Grip strength decreased 180.08 9.93 1142 846975 79032 109662150
Blood cholesterol increased 178.11 9.93 2184 845933 182601 109558581
Angioedema 177.56 9.93 301 847816 98199 109642983
Abortion spontaneous 177.47 9.93 623 847494 33659 109707523
Off label use 174.94 9.93 9570 838547 1490615 108250567
Renal impairment 172.33 9.93 800 847317 187645 109553537
C-reactive protein increased 166.53 9.93 2470 845647 215449 109525733
Arthritis 166.42 9.93 1992 846125 165594 109575588
Neoplasm progression 165.06 9.93 151 847966 64444 109676738
Hyponatraemia 164.93 9.93 985 847132 216668 109524514
Intentional product misuse 164.73 9.93 498 847619 132406 109608776
Product use issue 162.86 9.93 3324 844793 308371 109432811
Blood pressure systolic abnormal 160.54 9.93 487 847630 24363 109716819
Hip arthroplasty 158.53 9.93 846 847271 54967 109686215
Musculoskeletal pain 158.13 9.93 2120 845997 180903 109560279
Injury 157.60 9.93 2064 846053 175201 109565981
Oedema 157.34 9.93 2372 845745 207604 109533578
Cardio-respiratory arrest 153.86 9.93 420 847697 115416 109625766
Cytokine release syndrome 152.12 9.93 189 847928 70117 109671065
Blood pressure diastolic abnormal 152.09 9.93 490 847627 25325 109715857
Blood pressure fluctuation 151.79 9.93 1039 847078 73785 109667397
Mobility decreased 151.68 9.93 2612 845505 234810 109506372
Hypoglycaemia 151.21 9.93 425 847692 115679 109625503
Neuropathy peripheral 150.15 9.93 785 847332 178492 109562690
Hepatic failure 149.56 9.93 184 847933 68555 109672627
Infection 149.55 9.93 3736 844381 358464 109382718
Live birth 149.46 9.93 979 847138 68505 109672677
Bursitis 148.31 9.93 1587 846530 128331 109612851
Blood pressure systolic increased 145.64 9.93 1113 847004 81878 109659304
Drug dependence 143.91 9.93 104 848013 49916 109691266
Altered state of consciousness 142.21 9.93 139 847978 57487 109683695
General physical health deterioration 140.36 9.93 4262 843855 421033 109320149
Intentional product use issue 139.97 9.93 2675 845442 245231 109495951
Tachycardia 132.85 9.93 1105 847012 225540 109515642
Obesity 131.89 9.93 1390 846727 111961 109629221
Red blood cell sedimentation rate increased 130.70 9.93 1038 847079 77264 109663918
Intentional self-injury 127.03 9.93 64 848053 37365 109703817
Hyperglycaemia 126.63 9.93 291 847826 84799 109656383
Sepsis 125.72 9.93 1760 846357 325586 109415596
Poisoning 125.25 9.93 34 848083 29071 109712111
Respiratory depression 124.11 9.93 45 848072 31956 109709226
Joint effusion 122.43 9.93 396 847721 20509 109720673
Liver injury 122.06 9.93 1723 846394 148690 109592492
Shock 121.33 9.93 139 847978 53449 109687733
Wheezing 120.40 9.93 2682 845435 252548 109488634
Cytomegalovirus infection 120.28 9.93 144 847973 54300 109686882
Deep vein thrombosis postoperative 120.08 9.93 823 847294 58468 109682714
Wound infection 119.88 9.93 1199 846918 95266 109645916
Neurotoxicity 119.81 9.93 89 848028 42118 109699064
Hypoxia 118.29 9.93 550 847567 128965 109612217
Ventricular fibrillation 117.42 9.93 87 848030 41226 109699956
Palmar-plantar erythrodysaesthesia syndrome 117.11 9.93 86 848031 40939 109700243
Drug use disorder 117.01 9.93 5 848112 18069 109723113
Peripheral venous disease 116.64 9.93 1070 847047 83047 109658135
Anaphylactic shock 116.39 9.93 134 847983 51412 109689770
Product use in unapproved indication 115.10 9.93 2583 845534 444794 109296388
Sopor 114.59 9.93 69 848048 36477 109704705
Cognitive disorder 113.46 9.93 321 847796 87190 109653992
Breast cancer stage III 113.06 9.93 1013 847104 78104 109663078
Syncope 112.21 9.93 1002 847115 201534 109539648
Neutrophil count decreased 111.39 9.93 512 847605 120429 109620753
Nasal oedema 110.91 9.93 193 847924 6646 109734536
Sciatica 110.76 9.93 1140 846977 91259 109649923
Sedation complication 109.79 9.93 12 848105 19843 109721339
Metabolic acidosis 109.63 9.93 394 847723 99350 109641832
Gastrointestinal disorder 108.98 9.93 2526 845591 239426 109501756
Seizure 103.42 9.93 1140 846977 220045 109521137
Neuroleptic malignant syndrome 103.06 9.93 67 848050 33992 109707190
Suspected suicide 102.59 9.93 3 848114 15196 109725986
Nausea 102.26 9.93 8126 839991 1227564 108513618
Pain in extremity 101.59 9.93 4638 843479 482480 109258702
Tremor 101.58 9.93 1025 847092 201207 109539975
Suicidal ideation 100.65 9.93 375 847742 93562 109647620
Disability assessment scale score increased 100.54 9.93 143 847974 4127 109737055
Myalgia 100.10 9.93 1156 846961 221225 109519957
Autoimmune disorder 99.58 9.93 850 847267 64633 109676549
Ventricular tachycardia 99.48 9.93 143 847974 49866 109691316
Pulmonary fibrosis 98.25 9.93 1206 846911 100836 109640346
Blood creatine phosphokinase increased 97.01 9.93 265 847852 72812 109668370
Condition aggravated 95.94 9.93 6703 841414 728133 109013049
Foot deformity 94.67 9.93 667 847450 47813 109693369
Road traffic accident 93.54 9.93 1246 846871 106152 109635030
Bone erosion 93.50 9.93 643 847474 45728 109695454
Cardiac failure congestive 92.69 9.93 727 847390 150273 109590909
Chest discomfort 91.56 9.93 871 847246 172977 109568205
Joint stiffness 91.53 9.93 852 847265 66391 109674791
Ascites 91.47 9.93 383 847734 92425 109648757
Cardiogenic shock 91.17 9.93 189 847928 57149 109684033
No adverse event 90.54 9.93 278 847839 73561 109667621
Dry skin 90.32 9.93 471 847646 107182 109634000
Gait inability 89.82 9.93 1508 846609 134868 109606314
Mydriasis 89.66 9.93 29 848088 22128 109719054
Thrombocytopenia 88.93 9.93 2017 846100 346868 109394314
Acute hepatic failure 88.79 9.93 89 848028 36379 109704803
Drug withdrawal syndrome 88.02 9.93 97 848020 37957 109703225
Psoriasis 87.50 9.93 1535 846582 138458 109602724
Therapy partial responder 85.14 9.93 95 848022 36966 109704216
Polyarthritis 85.04 9.93 329 847788 18634 109722548
Lower limb fracture 84.85 9.93 918 847199 74430 109666752
Hypercholesterolaemia 84.63 9.93 1067 847050 89770 109651412
Blood pressure diastolic decreased 84.22 9.93 517 847600 35368 109705814
Wrong technique in product usage process 83.91 9.93 364 847753 86984 109654198
Enthesopathy 83.87 9.93 248 847869 12230 109728952
Blood glucose increased 83.62 9.93 633 847484 131863 109609319
Pancytopenia 83.44 9.93 2152 845965 207461 109533721
Hallucination 83.30 9.93 447 847670 100985 109640197
Vision blurred 83.05 9.93 613 847504 128409 109612773
Orthostatic hypotension 82.97 9.93 247 847870 66002 109675180
Accidental exposure to product 82.80 9.93 161 847956 49847 109691335
Myocardial infarction 82.79 9.93 1008 847109 191075 109550107
Platelet count decreased 81.82 9.93 1258 846859 229185 109511997
Adjustment disorder with depressed mood 81.78 9.93 597 847520 43286 109697896
Restlessness 81.63 9.93 195 847922 56064 109685118
Disseminated intravascular coagulation 81.20 9.93 119 847998 41167 109700015
Caesarean section 81.15 9.93 262 847855 13555 109727627
Lung disorder 80.83 9.93 1879 846238 178168 109563014
Aspergillus infection 80.82 9.93 48 848069 25568 109715614
Dislocation of vertebra 80.45 9.93 593 847524 43128 109698054
Post transplant lymphoproliferative disorder 80.14 9.93 12 848105 15601 109725581
Osteoporosis 79.61 9.93 1020 847097 86132 109655050
Skin exfoliation 79.57 9.93 373 847744 87278 109653904
Pathogen resistance 79.21 9.93 19 848098 17653 109723529
White blood cell count decreased 79.16 9.93 1259 846858 228131 109513051
Encephalopathy 78.95 9.93 336 847781 80719 109660463
Blood creatinine increased 78.35 9.93 961 847156 181928 109559254
Juvenile idiopathic arthritis 77.93 9.93 154 847963 5853 109735329
Onychomycosis 76.93 9.93 533 847584 37998 109703184
Injection site reaction 76.17 9.93 1030 847087 88040 109653142
Anaphylactic reaction 76.01 9.93 538 847579 113762 109627420
Exposure to toxic agent 75.82 9.93 6 848111 12852 109728330
Temperature regulation disorder 75.59 9.93 6 848111 12820 109728362
Onychomadesis 75.47 9.93 604 847513 45059 109696123
Heart rate decreased 75.36 9.93 968 847149 81788 109659394
Joint destruction 74.99 9.93 219 847898 10724 109730458
BK virus infection 74.87 9.93 7 848110 13099 109728083
Torsade de pointes 74.68 9.93 40 848077 22560 109718622
Rheumatoid nodule 74.41 9.93 331 847786 19965 109721217
Unresponsive to stimuli 74.13 9.93 246 847871 63544 109677638
Akathisia 73.62 9.93 20 848097 17093 109724089
Psychotic disorder 73.55 9.93 177 847940 50760 109690422
Venoocclusive liver disease 72.95 9.93 14 848103 15193 109725989
Hypoaesthesia 72.81 9.93 3025 845092 311198 109429984
Adverse event 72.69 9.93 1206 846911 107603 109633579
Diabetic ketoacidosis 72.63 9.93 132 847985 41926 109699256
Withdrawal syndrome 71.47 9.93 81 848036 31299 109709883
Rash 71.42 9.93 7264 840853 813700 108927482
Cytomegalovirus infection reactivation 70.72 9.93 26 848091 18307 109722875
Dehydration 70.62 9.93 1618 846499 277893 109463289
Dry mouth 70.27 9.93 2020 846097 197928 109543254
Creatinine renal clearance decreased 70.07 9.93 40 848077 21775 109719407
Atrial fibrillation 69.98 9.93 1289 846828 228353 109512829
Hyperkalaemia 69.96 9.93 684 847433 135112 109606070
Hypokalaemia 69.61 9.93 982 847135 181466 109559716
Night sweats 68.95 9.93 1426 846691 132557 109608625
Balance disorder 68.85 9.93 567 847550 115993 109625189
Drug level increased 68.76 9.93 166 847951 47553 109693629
COVID-19 68.45 9.93 1396 846721 243664 109497518
Respiratory tract infection 67.89 9.93 844 847273 70773 109670409
Thrombotic microangiopathy 67.75 9.93 74 848043 29075 109712107
Disease recurrence 67.52 9.93 239 847878 60545 109680637
Dysarthria 67.27 9.93 374 847743 83747 109657435
Haematotoxicity 67.23 9.93 39 848078 21043 109720139
Disturbance in attention 66.07 9.93 248 847869 61747 109679435
Cerebral infarction 65.83 9.93 192 847925 51646 109689536
Basal cell carcinoma 65.37 9.93 581 847536 44689 109696493
Substance abuse 65.32 9.93 9 848108 12454 109728728
Extrapyramidal disorder 65.22 9.93 75 848042 28792 109712390
Aggression 64.98 9.93 234 847883 58976 109682206
Proteinuria 64.40 9.93 131 847986 39887 109701295
Asphyxia 64.27 9.93 15 848102 14200 109726982
Miosis 64.16 9.93 45 848072 21938 109719244
Brain oedema 63.77 9.93 87 848030 31011 109710171
Abnormal behaviour 63.50 9.93 127 847990 38912 109702270
Sleep disorder 62.84 9.93 1981 846136 196663 109544519
Disorientation 62.82 9.93 303 847814 70368 109670814
C-reactive protein 62.59 9.93 423 847694 29908 109711274
Respiratory distress 62.57 9.93 293 847824 68581 109672601
Tenosynovitis 62.32 9.93 269 847848 16014 109725168
Dystonia 61.66 9.93 64 848053 25741 109715441
Fatigue 61.59 9.93 10411 837706 1205547 108535635
Loss of consciousness 61.34 9.93 1097 847020 195209 109545973
Exposure via skin contact 61.20 9.93 13 848104 13134 109728048
Acute chest syndrome 61.07 9.93 78 848039 2025 109739157
Appendicolith 60.69 9.93 17 848100 14238 109726944
Joint laxity 60.57 9.93 85 848032 2422 109738760
Cerebral haemorrhage 60.43 9.93 274 847843 64694 109676488
Anaemia 60.17 9.93 3507 844610 543579 109197603
Posterior reversible encephalopathy syndrome 59.62 9.93 105 848012 33756 109707426
Personality disorder 59.13 9.93 13 848104 12824 109728358
Dysphagia 58.85 9.93 826 847291 152774 109588408
Bronchopulmonary aspergillosis 58.80 9.93 86 848031 29777 109711405
Tumour lysis syndrome 58.42 9.93 91 848026 30710 109710472
Graft versus host disease 58.27 9.93 36 848081 18770 109722412
Blood pressure diastolic increased 57.50 9.93 291 847826 18516 109722666
Irritability 57.20 9.93 182 847935 47627 109693555
Laryngitis 56.53 9.93 535 847582 41876 109699306
Body temperature decreased 56.45 9.93 480 847637 36455 109704727
Graft versus host disease in gastrointestinal tract 56.38 9.93 3 848114 8965 109732217
Immune reconstitution inflammatory syndrome 56.19 9.93 27 848090 16199 109724983
Neurologic neglect syndrome 55.79 9.93 4 848113 9294 109731888
Device difficult to use 55.54 9.93 38 848079 18767 109722415
Acute graft versus host disease 55.52 9.93 15 848102 12866 109728316
Nail disorder 55.45 9.93 684 847433 57251 109683931
Pulmonary oedema 55.28 9.93 499 847618 100160 109641022
Palpitations 55.19 9.93 873 847244 158339 109582843
Mucormycosis 54.94 9.93 8 848109 10620 109730562
Dermatitis atopic 54.89 9.93 69 848048 25472 109715710
Muscle rigidity 54.76 9.93 62 848055 23969 109717213
Status epilepticus 54.60 9.93 99 848018 31472 109709710
Blepharospasm 54.41 9.93 652 847465 54199 109686983
Transplant rejection 54.24 9.93 65 848052 24502 109716680
Speech disorder 54.13 9.93 265 847852 61304 109679878
Bronchospasm 53.94 9.93 93 848024 30146 109711036
Coagulopathy 53.81 9.93 149 847968 40762 109700420
Drug dose omission by device 53.66 9.93 22 848095 14494 109726688
Hypothermia 53.52 9.93 74 848043 26228 109714954
Mental status changes 52.73 9.93 354 847763 75768 109665414
Nodule 52.50 9.93 429 847688 32202 109708980
Aphasia 52.41 9.93 253 847864 58744 109682438
Diarrhoea 52.31 9.93 7805 840312 1131700 108609482
Rebound effect 52.25 9.93 24 848093 14782 109726400
Ejection fraction decreased 51.49 9.93 152 847965 40728 109700454
Myoclonus 51.43 9.93 110 848007 32888 109708294
Loss of personal independence in daily activities 51.16 9.93 1510 846607 148510 109592672
Finger deformity 51.07 9.93 431 847686 32661 109708521
Adenovirus infection 50.91 9.93 11 848106 10983 109730199
Exostosis 50.85 9.93 558 847559 45398 109695784
Blood bilirubin increased 50.80 9.93 357 847760 75615 109665567
Polyomavirus-associated nephropathy 50.77 9.93 3 848114 8198 109732984
Ear infection 50.62 9.93 718 847399 62014 109679168
Localised infection 50.57 9.93 529 847588 42519 109698663
Unintentional medical device removal 50.35 9.93 5 848112 8918 109732264
Mania 50.35 9.93 51 848066 20745 109720437
Acute respiratory distress syndrome 50.30 9.93 223 847894 52975 109688207
Lupus-like syndrome 50.17 9.93 506 847611 40286 109700896
Second primary malignancy 50.13 9.93 39 848078 18029 109723153
Dyskinesia 49.65 9.93 214 847903 51232 109689950
Arrhythmia 49.48 9.93 321 847796 69254 109671928
Inappropriate antidiuretic hormone secretion 49.37 9.93 117 848000 33734 109707448
Coordination abnormal 49.33 9.93 73 848044 25155 109716027
Hypomagnesaemia 49.04 9.93 267 847850 60103 109681079
Premature rupture of membranes 48.65 9.93 109 848008 4528 109736654
Premature labour 48.61 9.93 168 847949 9004 109732178
X-ray abnormal 48.42 9.93 476 847641 37641 109703541
Cytopenia 48.11 9.93 99 848018 30017 109711165
Maternal exposure before pregnancy 47.51 9.93 143 847974 7122 109734060
Cerebrovascular accident 47.30 9.93 1044 847073 180240 109560942
Cytomegalovirus viraemia 47.22 9.93 40 848077 17724 109723458
Anti-cyclic citrullinated peptide antibody 47.08 9.93 288 847829 19676 109721506
Flushing 46.89 9.93 545 847572 104191 109636991
Hepatic cirrhosis 46.81 9.93 754 847363 66872 109674310
Leukopenia 46.63 9.93 831 847286 147960 109593222
Lymphocyte count decreased 46.59 9.93 253 847864 56990 109684192
Toxic epidermal necrolysis 46.57 9.93 250 847867 56477 109684705
Stevens-Johnson syndrome 46.55 9.93 193 847924 46708 109694474
Haemorrhage intracranial 46.47 9.93 95 848022 28874 109712308
Tachypnoea 46.41 9.93 151 847966 39244 109701938
Cardiotoxicity 46.13 9.93 37 848080 16844 109724338
Metastases to bone 46.10 9.93 108 848009 31264 109709918
Carotid artery thrombosis 45.97 9.93 9 848108 9629 109731553
Latent tuberculosis 45.73 9.93 97 848020 3880 109737302
Retinitis 45.71 9.93 413 847704 31914 109709268
Prescribed underdose 45.62 9.93 728 847389 64446 109676736
Fracture 45.48 9.93 336 847781 24452 109716730
Haemoptysis 45.44 9.93 340 847777 71014 109670168
Emotional distress 44.86 9.93 184 847933 44663 109696519
Muscle twitching 44.84 9.93 102 848015 29833 109711349
Metastases to central nervous system 43.67 9.93 67 848050 22750 109718432
Psychomotor hyperactivity 43.35 9.93 55 848062 20222 109720960
Blood pressure decreased 43.35 9.93 621 847496 114470 109626712
Chronic kidney disease 43.30 9.93 375 847742 75916 109665266
Prescribed overdose 43.06 9.93 926 847191 86655 109654527
Feeling abnormal 42.88 9.93 1056 847061 179655 109561527
Skin haemorrhage 42.80 9.93 78 848039 24749 109716433
Hemiplegia 42.56 9.93 68 848049 22714 109718468
Pre-eclampsia 42.04 9.93 154 847963 8496 109732686
Blood calcium decreased 41.81 9.93 138 847979 35707 109705475
Rash erythematous 41.80 9.93 413 847704 81419 109659763
Bacteraemia 41.72 9.93 175 847942 42215 109698967
Tuberculosis 41.66 9.93 256 847861 17518 109723664
Lupus vulgaris 41.53 9.93 420 847697 33463 109707719
Metastases to liver 41.43 9.93 136 847981 35250 109705932
Red blood cell sedimentation rate 41.30 9.93 110 848007 5104 109736078
Back injury 41.29 9.93 550 847567 46849 109694333
Cholestasis 41.29 9.93 307 847810 64211 109676971
Foetal exposure during pregnancy 41.12 9.93 139 847978 7366 109733816
Glycosylated haemoglobin increased 40.90 9.93 74 848043 23545 109717637
Hypophosphataemia 40.62 9.93 125 847992 33057 109708125
Joint dislocation 40.57 9.93 421 847696 33769 109707413
Depressed mood 40.53 9.93 286 847831 60523 109680659
Gamma-glutamyltransferase increased 40.06 9.93 290 847827 61019 109680163
Pseudomonas infection 40.04 9.93 97 848020 27756 109713426
Clostridium difficile colitis 39.90 9.93 186 847931 43592 109697590
Forced expiratory volume decreased 39.76 9.93 26 848091 13150 109728032
Paradoxical drug reaction 39.46 9.93 13 848104 9804 109731378
Sinus tachycardia 39.41 9.93 191 847926 44302 109696880
Tardive dyskinesia 39.36 9.93 28 848089 13551 109727631
Wheelchair user 39.29 9.93 141 847976 7701 109733481
Maternal exposure timing unspecified 39.23 9.93 286 847831 20727 109720455
Hemiparesis 39.15 9.93 188 847929 43715 109697467
Premature delivery 39.14 9.93 383 847734 30249 109710933
Multiple-drug resistance 38.75 9.93 27 848090 13208 109727974
Multiple sclerosis relapse 38.74 9.93 226 847891 50014 109691168
Coronary artery disease 38.66 9.93 357 847760 71333 109669849
Angina pectoris 38.64 9.93 299 847818 61996 109679186
Pleural effusion 38.56 9.93 1052 847065 176657 109564525
Haemophagocytic lymphohistiocytosis 38.56 9.93 119 847998 31440 109709742
Hepatotoxicity 38.54 9.93 306 847811 63094 109678088
Fear 38.11 9.93 75 848042 23118 109718064
Device expulsion 38.08 9.93 116 848001 30775 109710407
Potentiating drug interaction 37.90 9.93 21 848096 11622 109729560
Nocardiosis 37.86 9.93 6 848111 7480 109733702
Asthma-chronic obstructive pulmonary disease overlap syndrome 37.30 9.93 3 848114 6341 109734841
Schizophrenia 37.24 9.93 69 848048 21757 109719425
Diffuse large B-cell lymphoma recurrent 36.97 9.93 3 848114 6296 109734886
Cystitis haemorrhagic 36.96 9.93 24 848093 12185 109728997
Product dose omission issue 36.91 9.93 2054 846063 319728 109421454
Acidosis 36.90 9.93 73 848044 22458 109718724
Tongue disorder 36.77 9.93 211 847906 14087 109727095
Colitis ulcerative 36.76 9.93 814 847303 76549 109664633
Tendonitis 36.76 9.93 333 847784 25750 109715432
Acute respiratory failure 36.72 9.93 384 847733 74876 109666306
Gastrointestinal haemorrhage 36.65 9.93 977 847140 164541 109576641
Erythema multiforme 36.62 9.93 66 848051 21031 109720151
Anxiety 36.47 9.93 2220 845897 342858 109398324
Anuria 36.41 9.93 83 848034 24258 109716924
Alanine aminotransferase abnormal 36.34 9.93 155 847962 9179 109732003
Femur fracture 36.29 9.93 510 847607 43959 109697223
Dissociation 36.24 9.93 15 848102 9827 109731355
Myocarditis 36.24 9.93 114 848003 29941 109711241
Infective pulmonary exacerbation of cystic fibrosis 36.02 9.93 36 848081 14735 109726447
Haemodynamic instability 35.92 9.93 76 848041 22812 109718370
Lethargy 35.91 9.93 503 847614 93073 109648109
Eating disorder 35.85 9.93 119 847998 30739 109710443
Synovial cyst 35.75 9.93 178 847939 11252 109729930
Neck deformity 35.64 9.93 57 848060 1829 109739353
Lip swelling 35.41 9.93 235 847882 50432 109690750
Blood alkaline phosphatase increased 35.40 9.93 360 847757 70575 109670607
Septic shock 35.36 9.93 928 847189 156600 109584582
Haemorrhage 35.32 9.93 590 847527 106102 109635080
Electrocardiogram QRS complex prolonged 35.00 9.93 29 848088 12992 109728190
Food allergy 34.99 9.93 62 848055 19886 109721296
Leukocytosis 34.99 9.93 255 847862 53573 109687609
Euglycaemic diabetic ketoacidosis 34.98 9.93 23 848094 11600 109729582
Graft versus host disease in skin 34.85 9.93 10 848107 8244 109732938
Parkinsonism 34.54 9.93 74 848043 22113 109719069
Respiratory acidosis 34.52 9.93 33 848084 13793 109727389
Adjustment disorder 34.38 9.93 20 848097 10775 109730407
Drug tolerance decreased 33.57 9.93 341 847776 27199 109713983
Klebsiella infection 33.49 9.93 64 848053 19945 109721237
Melaena 33.47 9.93 351 847766 68406 109672776
Colorectal cancer 33.39 9.93 14 848103 9100 109732082
Pulmonary alveolar haemorrhage 33.25 9.93 65 848052 20085 109721097
Device use error 33.23 9.93 14 848103 9075 109732107
Sexual dysfunction 33.07 9.93 12 848105 8518 109732664
Cardiac failure acute 32.95 9.93 86 848031 23992 109717190
Bradyphrenia 32.94 9.93 25 848092 11703 109729479
Mental disorder 32.93 9.93 169 847948 38622 109702560
Skin ulcer 32.93 9.93 678 847439 62967 109678215
Motor dysfunction 32.77 9.93 88 848029 24318 109716864
Generalised tonic-clonic seizure 32.73 9.93 265 847852 54415 109686767
Fluid retention 32.71 9.93 517 847600 93790 109647392
Pneumothorax 32.70 9.93 149 847968 35136 109706046
Acute graft versus host disease in skin 32.67 9.93 21 848096 10719 109730463
Aspartate aminotransferase increased 32.61 9.93 955 847162 158981 109582201
Nephropathy toxic 32.59 9.93 105 848012 27373 109713809
Disability 32.54 9.93 365 847752 29858 109711324
Osteonecrosis of jaw 32.41 9.93 225 847892 47792 109693390
Injection site pruritus 32.36 9.93 563 847554 50695 109690487
Smear cervix abnormal 32.18 9.93 67 848050 2645 109738537
Diabetes mellitus 32.11 9.93 552 847565 98829 109642353
Bone pain 31.91 9.93 332 847785 64801 109676381
Injection site erythema 31.85 9.93 947 847170 93229 109647953
Oliguria 31.82 9.93 59 848058 18598 109722584
Ankylosing spondylitis 31.78 9.93 217 847900 15395 109725787
Liver function test increased 31.76 9.93 897 847220 87651 109653531
Diabetes insipidus 31.62 9.93 6 848111 6564 109734618
Mouth ulceration 31.57 9.93 532 847585 47606 109693576
Appendicitis 31.56 9.93 112 848005 28352 109712830
Spinal stenosis 31.45 9.93 252 847865 18804 109722378
Pneumatosis intestinalis 31.41 9.93 13 848104 8516 109732666
Pruritus genital 31.30 9.93 6 848111 6516 109734666
Scleritis 31.13 9.93 102 848015 5318 109735864
Urinary retention 31.03 9.93 363 847754 69320 109671862
Cyanosis 31.03 9.93 120 847997 29621 109711561
Hypomania 31.01 9.93 20 848097 10190 109730992
Candida infection 30.93 9.93 228 847889 47781 109693401
Endophthalmitis 30.93 9.93 12 848105 8175 109733007
Device leakage 30.83 9.93 47 848070 16001 109725181
Sinus bradycardia 30.73 9.93 119 847998 29364 109711818
Neck mass 30.69 9.93 94 848023 4727 109736455
Immune effector cell-associated neurotoxicity syndrome 30.67 9.93 41 848076 14741 109726441
Paranoia 30.55 9.93 80 848037 22294 109718888
Metastases to lung 30.33 9.93 84 848033 22979 109718203
Antinuclear antibody positive 30.27 9.93 145 847972 9023 109732159
Arthritis infective 30.24 9.93 159 847958 10270 109730912
Small for dates baby 30.17 9.93 31 848086 631 109740551
Tenderness 30.12 9.93 352 847765 29085 109712097
Hyperbilirubinaemia 29.95 9.93 127 847990 30544 109710638
Pulmonary haemorrhage 29.91 9.93 50 848067 16406 109724776
Multiple drug therapy 29.86 9.93 12 848105 8002 109733180
Pulmonary congestion 29.76 9.93 129 847988 30837 109710345
Stress cardiomyopathy 29.69 9.93 47 848070 15759 109725423
Limb deformity 29.64 9.93 79 848038 3667 109737515
Epstein-Barr virus infection 29.59 9.93 62 848055 18676 109722506
Ileus 29.54 9.93 128 847989 30601 109710581
Chills 29.53 9.93 1178 846939 189402 109551780
Pulseless electrical activity 29.47 9.93 52 848065 16705 109724477
Cardiac septal defect 29.46 9.93 37 848080 944 109740238
Cytomegalovirus chorioretinitis 29.43 9.93 9 848108 7119 109734063
Delusion 29.43 9.93 89 848028 23666 109717516
Pulmonary embolism 29.41 9.93 1344 846773 213130 109528052
Dyspepsia 29.34 9.93 1767 846350 189198 109551984
Pneumonia aspiration 29.30 9.93 442 847675 80791 109660391
Multiple fractures 29.23 9.93 141 847976 8799 109732383
Normal newborn 29.07 9.93 276 847841 21620 109719562
Eye pruritus 28.85 9.93 141 847976 32634 109708548
Glomerular filtration rate decreased 28.83 9.93 119 847998 28837 109712345
Jaundice cholestatic 28.83 9.93 42 848075 14566 109726616
Device related infection 28.78 9.93 181 847936 39338 109701844
Drug effective for unapproved indication 28.68 9.93 40 848077 14127 109727055
Dermatitis acneiform 28.66 9.93 33 848084 12662 109728520
Hyperammonaemia 28.58 9.93 38 848079 13694 109727488
Acute myeloid leukaemia 28.56 9.93 173 847944 37937 109703245
Seronegative arthritis 28.53 9.93 186 847931 12991 109728191
Acute generalised exanthematous pustulosis 28.42 9.93 79 848038 21585 109719597
Hyperlactacidaemia 28.37 9.93 14 848103 8272 109732910
Vasoplegia syndrome 28.34 9.93 4 848113 5435 109735747
Dyspnoea 28.16 9.93 7810 840307 1099062 108642120
Hypogammaglobulinaemia 28.01 9.93 71 848046 20005 109721177
Blood parathyroid hormone decreased 27.88 9.93 184 847933 12905 109728277
Migraine 27.83 9.93 1596 846521 170056 109571126
Hepatic encephalopathy 27.59 9.93 117 848000 28139 109713043
Cleft lip and palate 27.59 9.93 31 848086 701 109740481
Pulmonary arterial hypertension 27.59 9.93 142 847975 32426 109708756
Hypothyroidism 27.57 9.93 393 847724 72506 109668676
Central nervous system mass 27.54 9.93 33 848084 801 109740381
Frequent bowel movements 27.53 9.93 730 847387 70660 109670522
Wall motion score index abnormal 27.32 9.93 33 848084 808 109740374
Pancreatitis acute 27.22 9.93 313 847804 59961 109681221
Hallucination, auditory 27.22 9.93 107 848010 26290 109714892
Product preparation error 27.12 9.93 26 848091 10853 109730329
Subdural haematoma 27.05 9.93 166 847951 36288 109704894
Immune-mediated myositis 27.05 9.93 7 848110 6179 109735003
Cross sensitivity reaction 26.97 9.93 5 848112 5562 109735620
End stage renal disease 26.93 9.93 80 848037 21393 109719789
Rotator cuff repair 26.91 9.93 56 848061 2210 109738972
Paralysis 26.90 9.93 49 848068 15551 109725631
Sensory loss 26.86 9.93 80 848037 21377 109719805
Bronchitis 26.81 9.93 1467 846650 155565 109585617
Alanine aminotransferase increased 26.76 9.93 1144 846973 182629 109558553
Granuloma skin 26.76 9.93 163 847954 11120 109730062
Haematoma 26.67 9.93 303 847814 58173 109683009
Lung opacity 26.62 9.93 30 848087 11622 109729560
Hepatitis B reactivation 26.62 9.93 12 848105 7472 109733710
Rheumatoid lung 26.54 9.93 83 848034 4221 109736961
Malignant mediastinal neoplasm 26.52 9.93 42 848075 1336 109739846
Synovial disorder 26.46 9.93 66 848051 2941 109738241
Enterocolitis 26.45 9.93 67 848050 18882 109722300
Respiration abnormal 26.18 9.93 22 848095 9787 109731395
Sleep terror 26.14 9.93 9 848108 6601 109734581
Face oedema 26.11 9.93 150 847967 33319 109707863
Drug hypersensitivity 26.04 9.93 3916 844201 450174 109291008
Diplopia 26.02 9.93 201 847916 41693 109699489
Cardiac failure chronic 26.01 9.93 41 848076 13770 109727412
Hydrops foetalis 25.95 9.93 31 848086 750 109740432
Pyrexia 25.85 9.93 6303 841814 891962 108849220
Immune-mediated enterocolitis 25.79 9.93 24 848093 10161 109731021
Febrile bone marrow aplasia 25.76 9.93 60 848057 17405 109723777
Palmoplantar keratoderma 25.76 9.93 5 848112 5382 109735800
Cardiomyopathy 25.75 9.93 151 847966 33374 109707808
Dysphonia 25.75 9.93 418 847699 75511 109665671
Obstructive airways disorder 25.67 9.93 228 847889 45921 109695261
Jaundice 25.45 9.93 311 847806 58925 109682257
Accidental death 25.37 9.93 4 848113 5005 109736177
Bacterial infection 25.36 9.93 228 847889 45808 109695374
Blood lactic acid increased 25.28 9.93 52 848065 15769 109725413
Labelled drug-drug interaction medication error 25.25 9.93 127 847990 29175 109712007
Pulmonary hypertension 25.23 9.93 286 847831 54934 109686248
Atrial tachycardia 25.22 9.93 20 848097 9158 109732024
Strongyloidiasis 25.21 9.93 4 848113 4982 109736200
Gastroenteritis viral 25.03 9.93 357 847760 30869 109710313
Myasthenia gravis 24.96 9.93 83 848034 21428 109719754
Acute myocardial infarction 24.96 9.93 472 847645 83305 109657877
Skin papilloma 24.93 9.93 112 848005 6784 109734398
Blindness 24.72 9.93 170 847947 36189 109704993
Neck pain 24.65 9.93 1168 846949 121962 109619220
Exposure via ingestion 24.62 9.93 4 848113 4896 109736286
Venoocclusive disease 24.50 9.93 9 848108 6341 109734841
Product label confusion 24.47 9.93 274 847843 22403 109718779
Bladder cancer 24.45 9.93 77 848040 20215 109720967
Airway remodelling 24.35 9.93 33 848084 909 109740273
Abortion late 24.30 9.93 12 848105 68 109741114
Gangrene 24.21 9.93 56 848061 16285 109724897
Eosinophilia 24.20 9.93 306 847811 57630 109683552
Skin toxicity 24.12 9.93 33 848084 11750 109729432
Liver disorder 24.12 9.93 1328 846789 140915 109600267
Acute myeloid leukaemia recurrent 24.09 9.93 5 848112 5134 109736048
International normalised ratio increased 24.00 9.93 495 847622 86277 109654905
Product prescribing issue 23.97 9.93 38 848079 12734 109728448
Synovial fluid analysis 23.76 9.93 59 848058 2622 109738560
Ankle arthroplasty 23.52 9.93 57 848060 2494 109738688
Malignant melanoma 23.48 9.93 215 847902 16676 109724506
Hypernatraemia 23.42 9.93 65 848052 17768 109723414
Blood phosphorus increased 23.41 9.93 57 848060 16283 109724899
Toxic skin eruption 23.29 9.93 120 847997 27395 109713787
Peripheral sensory neuropathy 23.27 9.93 59 848058 16621 109724561
Right ventricular failure 23.23 9.93 111 848006 25843 109715339
Polyhydramnios 23.22 9.93 48 848069 1885 109739297
Swelling face 23.13 9.93 535 847582 91786 109649396
Chronic graft versus host disease 23.11 9.93 23 848094 9434 109731748
Treatment noncompliance 23.07 9.93 407 847710 72583 109668599
Sputum discoloured 23.02 9.93 123 847994 27822 109713360
Hyperuricaemia 23.01 9.93 48 848069 14483 109726699
Ventricular arrhythmia 23.01 9.93 26 848091 10061 109731121
Ketoacidosis 23.01 9.93 26 848091 10061 109731121
Drug tolerance 23.00 9.93 211 847906 16374 109724808
Affect lability 22.96 9.93 70 848047 18567 109722615
Virologic failure 22.84 9.93 5 848112 4947 109736235
Epistaxis 22.84 9.93 794 847323 129578 109611604
Subarachnoid haemorrhage 22.70 9.93 134 847983 29568 109711614
Pain in jaw 22.63 9.93 267 847850 50910 109690272
Rales 22.61 9.93 105 848012 24634 109716548
Bacterial sepsis 22.58 9.93 28 848089 10398 109730784
Panniculitis 22.50 9.93 200 847917 15382 109725800
Mucosal inflammation 22.47 9.93 563 847554 95578 109645604
Therapy interrupted 22.39 9.93 259 847858 49563 109691619
Rhinitis allergic 22.31 9.93 67 848050 17855 109723327
Polyuria 22.30 9.93 66 848051 17672 109723510
Fracture delayed union 22.27 9.93 51 848066 2150 109739032
Arterial occlusive disease 22.25 9.93 53 848064 15255 109725927
Myocardial ischaemia 22.23 9.93 117 848000 26567 109714615
Hypoxic-ischaemic encephalopathy 22.22 9.93 21 848096 8826 109732356
Blood urea increased 21.95 9.93 293 847824 54664 109686518
Hepatitis fulminant 21.88 9.93 20 848097 8540 109732642
Renal injury 21.85 9.93 72 848045 18641 109722541
Ultrasound antenatal screen 21.80 9.93 27 848090 679 109740503
Tenosynovitis stenosans 21.78 9.93 69 848048 3534 109737648
Acute coronary syndrome 21.78 9.93 97 848020 23015 109718167
Epilepsy 21.67 9.93 958 847159 99251 109641931
Gastric haemorrhage 21.66 9.93 57 848060 15858 109725324
Loose body in joint 21.64 9.93 39 848078 1381 109739801
Atrioventricular block complete 21.61 9.93 80 848037 20002 109721180
Polyneuropathy 21.61 9.93 150 847967 31862 109709320
Hepatitis acute 21.37 9.93 73 848044 18693 109722489
Hyperlipidaemia 21.33 9.93 174 847943 35674 109705508
COVID-19 pneumonia 21.33 9.93 182 847935 36961 109704221
Back pain 21.27 9.93 2505 845612 368491 109372691
Foot fracture 21.26 9.93 294 847823 25252 109715930
Bradypnoea 21.18 9.93 21 848096 8628 109732554
Hypercapnia 21.13 9.93 33 848084 11126 109730056
Vascular device infection 21.08 9.93 61 848056 16451 109724731
Bone disorder 21.06 9.93 252 847865 20940 109720242
Myopathy 21.04 9.93 109 848008 24851 109716331
Acute lymphocytic leukaemia recurrent 21.02 9.93 9 848108 5778 109735404
Hepatocellular injury 20.96 9.93 268 847849 50374 109690808
Placental disorder 20.88 9.93 32 848085 989 109740193
Pneumonia bacterial 20.86 9.93 117 848000 26144 109715038
Hyperthermia 20.82 9.93 88 848029 21184 109719998
Interstitial lung disease 20.78 9.93 865 847252 138469 109602713
Chronic obstructive pulmonary disease 20.72 9.93 658 847459 108500 109632682
Dysgeusia 20.63 9.93 395 847722 69590 109671592
Atopy 20.61 9.93 34 848083 1120 109740062
Amyloid arthropathy 20.52 9.93 42 848075 1638 109739544
Heparin-induced thrombocytopenia 20.50 9.93 35 848082 11389 109729793
Herpes zoster 20.42 9.93 1022 847095 107357 109633825
Anti-neutrophil cytoplasmic antibody positive vasculitis 20.37 9.93 8 848109 5409 109735773
Dizziness 20.34 9.93 4896 843221 693297 109047885
Metastasis 20.33 9.93 20 848097 8247 109732935
Skin burning sensation 20.32 9.93 92 848025 21733 109719449
Nail operation 20.27 9.93 42 848075 1652 109739530
Product administered to patient of inappropriate age 20.27 9.93 19 848098 8017 109733165
Product administration error 20.21 9.93 185 847932 37032 109704150
Hallucination, visual 20.17 9.93 200 847917 39405 109701777
Dyspnoea exertional 20.06 9.93 626 847491 103434 109637748
Respiratory disorder neonatal 20.06 9.93 10 848107 58 109741124
Oesophageal carcinoma 20.05 9.93 36 848081 11488 109729694
Hyperthermia malignant 20.01 9.93 3 848114 3897 109737285
Varicella zoster virus infection 20.00 9.93 12 848105 6356 109734826
Progressive multifocal leukoencephalopathy 19.92 9.93 111 848006 24845 109716337
Type 1 diabetes mellitus 19.91 9.93 24 848093 9023 109732159
Dysmorphism 19.87 9.93 25 848092 639 109740543
Hypocalcaemia 19.86 9.93 367 847750 64999 109676183
Troponin increased 19.83 9.93 140 847977 29626 109711556
Mucocutaneous ulceration 19.81 9.93 27 848090 748 109740434
Hyperprolactinaemia 19.80 9.93 13 848104 6562 109734620
Colitis microscopic 19.77 9.93 46 848071 13348 109727834
Breast feeding 19.75 9.93 26 848091 696 109740486
Abortion threatened 19.73 9.93 21 848096 446 109740736
Temperature intolerance 19.72 9.93 49 848068 13901 109727281
Weight decreased 19.67 9.93 3971 844146 464086 109277096
Affective disorder 19.66 9.93 35 848082 11206 109729976
Vascular stent thrombosis 19.61 9.93 4 848113 4157 109737025
Ventricular extrasystoles 19.58 9.93 98 848019 22543 109718639
Trisomy 18 19.58 9.93 24 848093 597 109740585
Toxic encephalopathy 19.57 9.93 56 848061 15158 109726024
Haemorrhage in pregnancy 19.55 9.93 41 848076 1627 109739555
Systemic mycosis 19.52 9.93 3 848114 3826 109737356
Circulatory collapse 19.52 9.93 223 847894 42770 109698412
Transplant dysfunction 19.51 9.93 21 848096 8307 109732875
Complications of transplanted kidney 19.49 9.93 17 848100 7425 109733757
Human antichimeric antibody positive 19.47 9.93 42 848075 1700 109739482
Pulmonary function test abnormal 19.44 9.93 7 848110 4993 109736189
Joint injury 19.38 9.93 422 847695 39572 109701610
Psychiatric decompensation 19.35 9.93 10 848107 5755 109735427
Amylase increased 19.29 9.93 42 848075 12477 109728705
Erectile dysfunction 19.27 9.93 75 848042 18481 109722701
Aphthous ulcer 19.14 9.93 247 847870 20889 109720293
Stillbirth 19.14 9.93 74 848043 4190 109736992
Linear IgA disease 19.13 9.93 5 848112 4384 109736798
Placental insufficiency 19.04 9.93 35 848082 1259 109739923
Blood glucose decreased 19.02 9.93 140 847977 29348 109711834
Atrioventricular block 18.98 9.93 66 848051 16811 109724371
Lower respiratory tract congestion 18.95 9.93 80 848037 4716 109736466
Swollen tongue 18.94 9.93 337 847780 60025 109681157
Total lung capacity decreased 18.93 9.93 16 848101 7098 109734084
Hypervolaemia 18.93 9.93 266 847851 49194 109691988
Ulcer haemorrhage 18.88 9.93 260 847857 22311 109718871
Foetal distress syndrome 18.79 9.93 24 848093 623 109740559
Visual acuity reduced 18.77 9.93 157 847960 32016 109709166
Device occlusion 18.73 9.93 57 848060 15128 109726054
Kidney transplant rejection 18.65 9.93 40 848077 11947 109729235
Acute graft versus host disease in intestine 18.60 9.93 10 848107 5629 109735553
Post-traumatic stress disorder 18.60 9.93 14 848103 6582 109734600
Human herpesvirus 6 infection 18.52 9.93 14 848103 6567 109734615
Diabetes mellitus inadequate control 18.42 9.93 143 847974 29632 109711550
Anticholinergic syndrome 18.42 9.93 5 848112 4275 109736907
Skin cancer 18.35 9.93 213 847904 17571 109723611
Folate deficiency 18.29 9.93 75 848042 4363 109736819
Anosmia 18.27 9.93 43 848074 12429 109728753
Dyslipidaemia 18.25 9.93 62 848055 15903 109725279
Osteopenia 18.24 9.93 255 847862 21954 109719228
Mood altered 18.22 9.93 93 848024 21282 109719900
Spondylitis 18.20 9.93 149 847968 11189 109729993
Syringe issue 18.20 9.93 28 848089 9497 109731685
Metabolic disorder 18.13 9.93 33 848084 10477 109730705
Creatinine renal clearance increased 18.12 9.93 3 848114 3622 109737560
Pericardial effusion 18.10 9.93 319 847798 56898 109684284
Head injury 18.05 9.93 227 847890 42790 109698392
Breast cancer stage I 18.01 9.93 18 848099 7369 109733813
Ingrown hair 17.98 9.93 26 848091 762 109740420
Immune-mediated hepatitis 17.98 9.93 15 848102 6696 109734486
Sleep disorder due to a general medical condition 17.96 9.93 286 847831 51826 109689356
Nervous system disorder 17.96 9.93 156 847961 31565 109709617
Generalised oedema 17.83 9.93 150 847967 30554 109710628
Lymphatic fistula 17.82 9.93 37 848080 1458 109739724
Lipase increased 17.81 9.93 78 848039 18594 109722588
Depressive symptom 17.80 9.93 23 848094 8391 109732791
Sneezing 17.80 9.93 158 847959 31826 109709356
Postoperative wound infection 17.76 9.93 192 847925 15561 109725621
Long QT syndrome 17.76 9.93 17 848100 7101 109734081
Squamous cell carcinoma of lung 17.75 9.93 54 848063 2705 109738477
Extra dose administered 17.75 9.93 42 848075 12117 109729065
Hypophagia 17.75 9.93 290 847827 52336 109688846
Salivary hypersecretion 17.72 9.93 71 848046 17350 109723832
Anaemia macrocytic 17.63 9.93 106 848011 7197 109733985
Bradykinesia 17.63 9.93 35 848082 10753 109730429
Femoral hernia incarcerated 17.58 9.93 37 848080 1472 109739710
Drug screen positive 17.58 9.93 14 848103 6396 109734786
Poor venous access 17.57 9.93 275 847842 24247 109716935
Foot operation 17.56 9.93 106 848011 7207 109733975
Walking aid user 17.51 9.93 280 847837 24795 109716387
Pulmonary tuberculosis 17.41 9.93 125 847992 9014 109732168
Confusional state 17.40 9.93 3953 844164 464727 109276455
Multiple allergies 17.40 9.93 43 848074 12220 109728962
Laryngospasm 17.38 9.93 7 848110 4661 109736521
Capillary leak syndrome 17.25 9.93 8 848109 4900 109736282
Pharyngeal swelling 17.22 9.93 42 848075 11990 109729192
Ischaemic stroke 17.21 9.93 218 847899 41045 109700137
Thrombosis 17.19 9.93 670 847447 107992 109633190
Cryptococcosis 17.15 9.93 7 848110 4624 109736558
Hyperpyrexia 17.13 9.93 22 848095 8047 109733135
Polyomavirus viraemia 17.09 9.93 3 848114 3471 109737711
Intervertebral disc degeneration 17.08 9.93 213 847904 17872 109723310
Hypoalbuminaemia 17.08 9.93 141 847976 28833 109712349
Total lung capacity increased 16.96 9.93 9 848108 5103 109736079
Prostatic specific antigen increased 16.88 9.93 45 848072 12466 109728716
Oligohydramnios 16.86 9.93 68 848049 3926 109737256
Post procedural infection 16.84 9.93 171 847946 13638 109727544
Short stature 16.75 9.93 30 848087 1057 109740125
Joint noise 16.73 9.93 81 848036 5062 109736120
Immunosuppression 16.70 9.93 209 847908 17550 109723632
Spinal osteoarthritis 16.68 9.93 232 847885 19951 109721231
Hydrocephalus 16.66 9.93 34 848083 10341 109730841
Disturbance in social behaviour 16.64 9.93 9 848108 5049 109736133
Presyncope 16.62 9.93 269 847848 48618 109692564
Body height below normal 16.54 9.93 44 848073 2040 109739142
Panic attack 16.53 9.93 142 847975 28798 109712384
Intracranial pressure increased 16.52 9.93 35 848082 10500 109730682
Fear of injection 16.47 9.93 121 847996 8790 109732392
Congestive cardiomyopathy 16.40 9.93 55 848062 14164 109727018
Left ventricular dysfunction 16.39 9.93 109 848008 23384 109717798
Bronchioloalveolar carcinoma 16.39 9.93 8 848109 44 109741138
Polydipsia 16.28 9.93 21 848096 7667 109733515
Wound infection pseudomonas 16.28 9.93 48 848069 2363 109738819
Plasma cell myeloma recurrent 16.23 9.93 18 848099 7024 109734158
Acute pulmonary oedema 16.21 9.93 71 848046 16925 109724257
Genital haemorrhage 16.21 9.93 19 848098 7233 109733949
Maternal exposure during breast feeding 16.21 9.93 70 848047 4168 109737014
Induced labour 16.14 9.93 27 848090 900 109740282
Hypotonia 16.12 9.93 64 848053 15681 109725501
Pain of skin 16.04 9.93 89 848028 19940 109721242
Breast cancer stage II 15.98 9.93 297 847820 27078 109714104
Nasal polyps 15.96 9.93 50 848067 13150 109728032
Nightmare 15.96 9.93 206 847911 38657 109702525
Product dose omission in error 15.95 9.93 110 848007 23402 109717780
Tetany 15.91 9.93 4 848113 3600 109737582
Bronchial carcinoma 15.90 9.93 33 848084 1300 109739882
Infusion site pain 15.88 9.93 74 848043 17345 109723837
Epstein-Barr viraemia 15.74 9.93 4 848113 3575 109737607
Lymphopenia 15.74 9.93 215 847902 39955 109701227
Full blood count abnormal 15.72 9.93 319 847798 55733 109685449
Hypertransaminasaemia 15.71 9.93 115 848002 24140 109717042
Nervousness 15.63 9.93 194 847923 36657 109704525
Asthenia 15.63 9.93 4884 843233 684115 109057067
Incoherent 15.56 9.93 25 848092 8333 109732849
Antibody test positive 15.55 9.93 56 848061 3064 109738118
Mitochondrial toxicity 15.54 9.93 3 848114 3242 109737940
Incorrect dose administered 15.54 9.93 643 847474 102998 109638184
Complication of device removal 15.53 9.93 8 848109 4612 109736570
Haematemesis 15.52 9.93 340 847777 58768 109682414
Twin pregnancy 15.49 9.93 27 848090 931 109740251
Anger 15.47 9.93 84 848033 18923 109722259
Cyst 15.46 9.93 194 847923 16302 109724880
Anal fissure 15.41 9.93 129 847988 9752 109731430
Erythema 15.31 9.93 1979 846138 289468 109451714
Muscle spasticity 15.26 9.93 189 847928 35726 109705456
Cervical dysplasia 15.23 9.93 51 848066 2689 109738493
Hypoventilation 15.21 9.93 24 848093 8057 109733125
Corneal oedema 15.05 9.93 3 848114 3170 109738012
Laryngeal oedema 15.03 9.93 33 848084 9774 109731408
Complication of device insertion 15.03 9.93 28 848089 8810 109732372
Anhedonia 14.99 9.93 64 848053 15364 109725818
Asthma 14.99 9.93 2164 845953 248127 109493055
Oesophageal fibrosis 14.98 9.93 12 848105 174 109741008
Kounis syndrome 14.96 9.93 14 848103 5911 109735271
Brain injury 14.96 9.93 53 848064 13423 109727759
Haematocrit decreased 14.94 9.93 635 847482 65482 109675700
Hepatitis C 14.94 9.93 48 848069 12525 109728657
Electrolyte imbalance 14.94 9.93 197 847920 36831 109704351
Reticulocyte count increased 14.93 9.93 36 848081 1570 109739612
Systemic candida 14.93 9.93 34 848083 9940 109731242
Foetal anticonvulsant syndrome 14.92 9.93 14 848103 254 109740928
Acute lung injury 14.91 9.93 3 848114 3148 109738034
Abortion missed 14.88 9.93 35 848082 1502 109739680
Compartment syndrome 14.88 9.93 14 848103 5896 109735286
Therapy non-responder 14.79 9.93 1400 846717 155907 109585275
Bone density increased 14.75 9.93 27 848090 968 109740214
Granulocyte count decreased 14.73 9.93 6 848111 3968 109737214
Sickle cell anaemia 14.72 9.93 24 848093 783 109740399
Hyperphosphataemia 14.69 9.93 70 848047 16311 109724871
Benign ovarian tumour 14.68 9.93 18 848099 448 109740734
Systemic inflammatory response syndrome 14.67 9.93 51 848066 12992 109728190
Renal cancer 14.64 9.93 51 848066 12983 109728199
Spinal cord compression 14.62 9.93 22 848095 7530 109733652
Osteonecrosis 14.55 9.93 177 847940 33564 109707618
Breast cancer female 14.54 9.93 48 848069 12420 109728762
Ileus paralytic 14.52 9.93 44 848073 11693 109729489
Adverse drug reaction 14.42 9.93 967 847150 104592 109636590
Aspiration 14.40 9.93 157 847960 30376 109710806
Pulmonary pain 14.35 9.93 90 848027 6203 109734979
Plasma cell myeloma 14.32 9.93 370 847747 62566 109678616
Throat tightness 14.32 9.93 176 847941 33313 109707869
Hand fracture 14.28 9.93 109 848008 8013 109733169
Cushingoid 14.27 9.93 145 847972 11567 109729615
Oropharyngeal pain 14.26 9.93 1214 846903 134062 109607120
Iritis 14.23 9.93 72 848045 4580 109736602
Metastases to lymph nodes 14.22 9.93 63 848054 14969 109726213
Device issue 14.20 9.93 183 847934 34352 109706830
Diaphragmatic disorder 14.15 9.93 39 848078 1847 109739335
Obsessive-compulsive disorder 14.11 9.93 21 848096 7220 109733962
Clostridium test positive 14.08 9.93 40 848077 10853 109730329
Concomitant disease aggravated 14.06 9.93 71 848046 16293 109724889
Blood folate increased 14.04 9.93 20 848097 578 109740604
Intraocular pressure increased 14.02 9.93 40 848077 10836 109730346
Pancreatic steatosis 13.99 9.93 38 848079 1784 109739398
Hyperthyroidism 13.99 9.93 150 847967 29111 109712071
Device loosening 13.97 9.93 24 848093 818 109740364
Injection site warmth 13.95 9.93 199 847918 17206 109723976
Viraemia 13.94 9.93 7 848110 4095 109737087
Brain natriuretic peptide increased 13.88 9.93 42 848075 11167 109730015
Mental impairment 13.88 9.93 109 848008 22530 109718652
Colitis 13.86 9.93 642 847475 101681 109639501
Epstein-Barr virus infection reactivation 13.83 9.93 7 848110 4077 109737105
Pneumomediastinum 13.81 9.93 11 848106 5025 109736157
Hyperventilation 13.80 9.93 30 848087 8917 109732265
Epstein-Barr virus associated lymphoproliferative disorder 13.79 9.93 10 848107 4792 109736390
Hospitalisation 13.78 9.93 924 847193 141569 109599613
Steroid diabetes 13.76 9.93 12 848105 5242 109735940
Radiation inflammation 13.76 9.93 27 848090 1021 109740161
Bronchial secretion retention 13.74 9.93 11 848106 5013 109736169
Endodontic procedure 13.73 9.93 54 848063 3082 109738100
Tumour haemorrhage 13.71 9.93 12 848105 5233 109735949
Shock haemorrhagic 13.71 9.93 138 847979 27109 109714073
Insurance issue 13.70 9.93 39 848078 10573 109730609
Extravascular haemolysis 13.68 9.93 17 848100 429 109740753
Staphylococcal infection 13.67 9.93 420 847697 69524 109671658
Activated partial thromboplastin time prolonged 13.57 9.93 108 848009 22260 109718922
Product prescribing error 13.56 9.93 295 847822 51036 109690146
C-reactive protein decreased 13.48 9.93 51 848066 2858 109738324
Enterococcal infection 13.47 9.93 96 848021 20270 109720912
Device breakage 13.45 9.93 57 848060 13712 109727470
Rash macular 13.44 9.93 212 847905 38474 109702708
Tension headache 13.43 9.93 34 848083 9584 109731598
Pupillary reflex impaired 13.42 9.93 7 848110 4008 109737174
Anal fistula 13.42 9.93 111 848006 8362 109732820
Drug abuser 13.40 9.93 13 848104 5396 109735786
Delayed graft function 13.40 9.93 8 848109 4249 109736933
Bone cyst 13.39 9.93 59 848058 3544 109737638
Dactylitis 13.38 9.93 65 848052 4068 109737114
Cervix haematoma uterine 13.30 9.93 4 848113 3 109741179
Accidental exposure to product by child 13.27 9.93 4 848113 3194 109737988
Skin weeping 13.27 9.93 6 848111 3729 109737453
Unevaluable event 13.26 9.93 349 847768 58878 109682304
Pneumonia fungal 13.26 9.93 63 848054 14691 109726491
Nail injury 13.26 9.93 23 848094 790 109740392
Respiratory tract congestion 13.26 9.93 162 847955 30695 109710487
Hepatic cytolysis 13.24 9.93 321 847796 54732 109686450
Dysuria 13.20 9.93 356 847761 59875 109681307
Eyelid ptosis 13.13 9.93 55 848062 13272 109727910
Fistula 13.11 9.93 177 847940 15122 109726060
Eosinophil count increased 13.09 9.93 101 848016 20957 109720225
Autonomic nervous system imbalance 13.07 9.93 15 848102 5765 109735417
Secondary adrenocortical insufficiency 13.04 9.93 9 848108 4425 109736757
Hepatitis cholestatic 13.03 9.93 80 848037 17486 109723696
Therapeutic response decreased 13.01 9.93 883 847234 95616 109645566
Type I hypersensitivity 12.99 9.93 18 848099 6375 109734807
Hypovolaemia 12.99 9.93 105 848012 21569 109719613
Ataxia 12.96 9.93 158 847959 29950 109711232
Peritoneal dialysis complication 12.94 9.93 46 848071 2500 109738682
Epidermal necrosis 12.93 9.93 52 848065 2998 109738184
Abdominal pain upper 12.90 9.93 2944 845173 346167 109395015
Schizoaffective disorder 12.88 9.93 4 848113 3132 109738050
Blood pressure increased 12.84 9.93 2211 845906 256162 109485020
Areflexia 12.84 9.93 20 848097 6749 109734433
Hypertriglyceridaemia 12.81 9.93 72 848045 16082 109725100
Inadequate analgesia 12.81 9.93 12 848105 5065 109736117
Rash maculo-papular 12.77 9.93 453 847664 73769 109667413
Ligament rupture 12.73 9.93 63 848054 3972 109737210
Tumour marker increased 12.72 9.93 12 848105 5048 109736134
Embolism 12.71 9.93 73 848044 16216 109724966
Lacrimal disorder 12.69 9.93 18 848099 518 109740664
Drooling 12.69 9.93 22 848095 7117 109734065
Paronychia 12.69 9.93 43 848074 11038 109730144
Rhinovirus infection 12.66 9.93 47 848070 11742 109729440
Hypospadias 12.66 9.93 10 848107 142 109741040
Catarrh 12.66 9.93 98 848019 7237 109733945
Aortic arteriosclerosis 12.65 9.93 134 847983 10804 109730378
Hepatitis B 12.65 9.93 35 848082 9577 109731605
Brain herniation 12.63 9.93 31 848086 8832 109732350
Angina unstable 12.63 9.93 74 848043 16358 109724824
Defaecation disorder 12.62 9.93 23 848094 822 109740360
Lymph gland infection 12.61 9.93 20 848097 637 109740545
Electrocardiogram T wave alternans 12.60 9.93 10 848107 143 109741039
Cystoid macular oedema 12.57 9.93 3 848114 2797 109738385
Hypochloraemia 12.56 9.93 6 848111 3612 109737570
Agranulocytosis 12.53 9.93 369 847748 61391 109679791
Fungaemia 12.51 9.93 17 848100 6069 109735113
Sudden death 12.51 9.93 123 847994 24272 109716910
Terminal state 12.50 9.93 15 848102 5652 109735530
Porphyria acute 12.48 9.93 208 847909 18572 109722610
Abortion incomplete 12.47 9.93 4 848113 3068 109738114
Speech disorder developmental 12.46 9.93 24 848093 895 109740287
Pancreatitis 12.44 9.93 588 847529 92945 109648237
Low birth weight baby 12.42 9.93 23 848094 832 109740350
Cervical incompetence 12.41 9.93 18 848099 529 109740653
Infection reactivation 12.39 9.93 8 848109 4073 109737109
Bronchopulmonary aspergillosis allergic 12.39 9.93 29 848088 8397 109732785
Threatened labour 12.36 9.93 20 848097 648 109740534
Bone density abnormal 12.36 9.93 61 848056 3842 109737340
Oculogyric crisis 12.35 9.93 7 848110 3825 109737357
Impaired gastric emptying 12.34 9.93 56 848061 13219 109727963
Cholangitis 12.32 9.93 74 848043 16261 109724921
Reversible cerebral vasoconstriction syndrome 12.32 9.93 11 848106 4750 109736432
Hepatic cancer 12.30 9.93 44 848073 11112 109730070
Lower gastrointestinal haemorrhage 12.29 9.93 87 848030 18399 109722783
Haemorrhagic transformation stroke 12.24 9.93 4 848113 3033 109738149
Product administration interrupted 12.14 9.93 45 848072 11247 109729935
Immune thrombocytopenia 12.13 9.93 112 848005 22382 109718800
Microangiopathy 12.07 9.93 50 848067 2922 109738260
Illness 12.06 9.93 511 847606 81660 109659522
Fine motor skill dysfunction 12.06 9.93 86 848031 6188 109734994
Cyst rupture 12.04 9.93 23 848094 852 109740330
Alcohol abuse 12.03 9.93 12 848105 4917 109736265
Hypertensive crisis 12.03 9.93 124 847993 24248 109716934
Joint lock 12.03 9.93 57 848060 3531 109737651
Quadriparesis 12.03 9.93 11 848106 4696 109736486
Crying 12.00 9.93 132 847985 25496 109715686
Amniotic fluid volume increased 11.94 9.93 10 848107 155 109741027
Brain abscess 11.93 9.93 21 848096 6753 109734429
Heart rate increased 11.92 9.93 945 847172 142889 109598293
Myoglobin blood increased 11.91 9.93 9 848108 4223 109736959
Dermatitis bullous 11.90 9.93 82 848035 17447 109723735
Swollen joint count 11.85 9.93 110 848007 8564 109732618
CD4 lymphocytes decreased 11.85 9.93 4 848113 2970 109738212
Immune-mediated myocarditis 11.84 9.93 6 848111 3492 109737690
Facial pain 11.83 9.93 69 848048 15270 109725912
Joint warmth 11.80 9.93 39 848078 2043 109739139
Vertigo 11.77 9.93 545 847572 86325 109654857
Exercise tolerance decreased 11.76 9.93 50 848067 12017 109729165
Personality change 11.73 9.93 44 848073 10958 109730224
Clear cell renal cell carcinoma 11.70 9.93 47 848070 2709 109738473
Lymphoproliferative disorder 11.67 9.93 95 848022 7123 109734059
Renal tubular necrosis 11.62 9.93 164 847953 30311 109710871
Accessory spleen 11.61 9.93 11 848106 202 109740980
Vomiting 11.60 9.93 6587 841530 904088 108837094
Ulcer 11.60 9.93 422 847695 42694 109698488
Cogwheel rigidity 11.57 9.93 7 848110 3691 109737491
Human anti-human antibody test 11.55 9.93 15 848102 396 109740786
Hepatocellular carcinoma 11.55 9.93 38 848079 9842 109731340
Alcohol interaction 11.54 9.93 7 848110 3687 109737495
Transient aphasia 11.49 9.93 20 848097 689 109740493
Medication error 11.49 9.93 948 847169 104418 109636764
Retinal haemorrhage 11.48 9.93 36 848081 9465 109731717
B-cell lymphoma 11.48 9.93 94 848023 7060 109734122
Liver transplant rejection 11.46 9.93 8 848109 3910 109737272
Pneumonitis 11.43 9.93 475 847642 76056 109665126
Haematuria 11.40 9.93 520 847597 82485 109658697
Tuberculin test positive 11.39 9.93 57 848060 3611 109737571
Infusion site erythema 11.38 9.93 50 848067 11909 109729273
Cholestasis of pregnancy 11.38 9.93 28 848089 1237 109739945
Failed induction of labour 11.36 9.93 13 848104 300 109740882
Blood lactate dehydrogenase increased 11.36 9.93 256 847861 44078 109697104
Prothrombin consumption time prolonged 11.36 9.93 6 848111 40 109741142
Tender joint count increased 11.35 9.93 15 848102 403 109740779
Oligoarthritis 11.33 9.93 21 848096 760 109740422
Post procedural haemorrhage 11.32 9.93 71 848046 15441 109725741
Thirst 11.32 9.93 109 848008 21598 109719584
Hepatic cyst 11.29 9.93 100 848017 7683 109733499
Fibroadenoma of breast 11.28 9.93 20 848097 699 109740483
Palmoplantar pustulosis 11.28 9.93 24 848093 962 109740220
Escherichia bacteraemia 11.26 9.93 40 848077 10124 109731058
Hepatitis 11.26 9.93 819 847298 89235 109651947
Parvovirus B19 infection 11.26 9.93 4 848113 2877 109738305
Postpartum haemorrhage 11.26 9.93 36 848081 1853 109739329
Cardiac dysfunction 11.23 9.93 19 848098 6204 109734978
Increased appetite 11.22 9.93 68 848049 14909 109726273
Thinking abnormal 11.20 9.93 69 848048 15071 109726111
Hypertelorism 11.18 9.93 10 848107 170 109741012
Immunosuppressant drug level increased 11.17 9.93 49 848068 11675 109729507
Capillary fragility 11.16 9.93 12 848105 258 109740924
Sinus disorder 11.15 9.93 180 847937 32548 109708634
Poor quality device used 11.15 9.93 4 848113 2859 109738323
Heart rate irregular 11.14 9.93 343 847774 33931 109707251
Trismus 11.12 9.93 21 848096 6575 109734607
Pemphigoid 11.12 9.93 97 848020 19610 109721572
Motor developmental delay 11.12 9.93 12 848105 259 109740923
Breast cancer metastatic 11.10 9.93 46 848071 11135 109730047
Middle insomnia 11.09 9.93 102 848015 20400 109720782
Tubulointerstitial nephritis 11.09 9.93 324 847793 53960 109687222
Troponin T increased 11.08 9.93 10 848107 4296 109736886
Blood creatine increased 11.07 9.93 48 848069 11473 109729709
Injection site bruising 11.06 9.93 490 847627 50773 109690409
Mesothelioma 11.06 9.93 14 848103 360 109740822
Eyelid oedema 11.06 9.93 70 848047 15192 109725990
Urine ketone body present 11.06 9.93 8 848109 3838 109737344
Hypothalamo-pituitary disorder 11.04 9.93 4 848113 2842 109738340
Anaesthetic complication 11.04 9.93 7 848110 3599 109737583
Inflammatory marker increased 11.03 9.93 164 847953 14305 109726877
Injection site extravasation 11.03 9.93 123 847994 10046 109731136
Hepatic necrosis 11.03 9.93 39 848078 9883 109731299
Tooth abscess 11.02 9.93 204 847913 18585 109722597
Upper gastrointestinal haemorrhage 11.00 9.93 296 847821 49800 109691382
Taste disorder 10.99 9.93 610 847507 64777 109676405
Cardiopulmonary failure 10.99 9.93 28 848089 7875 109733307
Bradyarrhythmia 10.95 9.93 13 848104 4921 109736261
Vein disorder 10.95 9.93 84 848033 6186 109734996
Eczema 10.95 9.93 448 847669 71845 109669337
Cardiac tamponade 10.93 9.93 47 848070 11260 109729922
Bronchial obstruction 10.85 9.93 5 848112 3074 109738108
Bone fissure 10.85 9.93 18 848099 596 109740586
Maternal exposure during delivery 10.80 9.93 7 848110 3558 109737624
Wrong technique in device usage process 10.76 9.93 23 848094 6878 109734304
Carcinoid tumour of the small bowel 10.75 9.93 15 848102 425 109740757
Infusion site reaction 10.73 9.93 193 847924 17489 109723693
Osteochondrosis 10.71 9.93 43 848074 2478 109738704
Renal disorder 10.70 9.93 293 847824 49186 109691996
Urinary incontinence 10.70 9.93 287 847830 48300 109692882
Purging 10.67 9.93 6 848111 46 109741136
Nystagmus 10.66 9.93 49 848068 11528 109729654
Anal prolapse 10.66 9.93 7 848110 73 109741109
Blood pressure inadequately controlled 10.65 9.93 27 848090 7606 109733576
Lung transplant 10.63 9.93 15 848102 5271 109735911
Neutrophilia 10.57 9.93 42 848075 10287 109730895
Polycythaemia 10.53 9.93 6 848111 3269 109737913
Plasmacytoma 10.51 9.93 15 848102 5247 109735935
Acquired gene mutation 10.47 9.93 4 848113 2750 109738432
Toxoplasma serology positive 10.45 9.93 6 848111 48 109741134
Neoplasm recurrence 10.37 9.93 15 848102 5217 109735965
Hypopituitarism 10.36 9.93 11 848106 4379 109736803
Nasal obstruction 10.36 9.93 52 848065 3298 109737884
Roseola 10.31 9.93 4 848113 11 109741171
Congenital umbilical hernia 10.31 9.93 4 848113 11 109741171
Injection site swelling 10.30 9.93 576 847541 61214 109679968
Infusion site pruritus 10.28 9.93 14 848103 4994 109736188
Ear pain 10.25 9.93 503 847614 52723 109688459
Pelvic fracture 10.24 9.93 159 847958 13995 109727187
Therapeutic product effect variable 10.24 9.93 4 848113 2714 109738468
Myofascial pain syndrome 10.23 9.93 43 848074 2530 109738652
Axonal neuropathy 10.22 9.93 40 848077 2278 109738904
Pseudomembranous colitis 10.22 9.93 21 848096 6370 109734812
Breast abscess 10.21 9.93 33 848084 1708 109739474
Methaemoglobinaemia 10.21 9.93 36 848081 9132 109732050
Eye swelling 10.21 9.93 185 847932 32863 109708319
Lung adenocarcinoma 10.21 9.93 115 848002 9416 109731766
Bundle branch block right 10.18 9.93 54 848063 12237 109728945
Deformity 10.18 9.93 121 847996 10039 109731143
Candida sepsis 10.14 9.93 5 848112 2956 109738226
Joint ankylosis 10.14 9.93 42 848075 2455 109738727
Skin graft failure 10.13 9.93 11 848106 239 109740943
Choking 10.10 9.93 71 848046 15039 109726143
Meningitis cryptococcal 10.09 9.93 13 848104 4749 109736433
Injection site rash 10.07 9.93 243 847874 23176 109718006
Hyperreflexia 10.07 9.93 38 848079 9447 109731735
Lymphoedema 10.05 9.93 70 848047 14859 109726323
Hereditary angioedema 10.05 9.93 25 848092 7089 109734093
Eosinophilic myocarditis 10.03 9.93 37 848080 2048 109739134
Immunisation 9.99 9.93 6 848111 3177 109738005
Transaminases increased 9.99 9.93 391 847726 62999 109678183
Intentional dose omission 9.98 9.93 102 848015 19978 109721204
Resuscitation 9.98 9.93 5 848112 2928 109738254
Hypoproteinaemia 9.96 9.93 19 848098 5926 109735256
Arteriospasm coronary 9.96 9.93 36 848081 9064 109732118
Bone lesion 9.94 9.93 25 848092 7062 109734120
Pharyngitis streptococcal 9.94 9.93 150 847967 13127 109728055

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Small for dates baby 19.43 19.32 173 3013 3567 107200

Pharmacologic Action:

SourceCodeDescription
ATC B03AD01 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in combination with folic acid
ATC B03AD02 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in combination with folic acid
ATC B03AD03 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in combination with folic acid
ATC B03AD04 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in combination with folic acid
ATC B03AD05 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in combination with folic acid
ATC B03AE01 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in other combinations
ATC B03AE02 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in other combinations
ATC B03BB01 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
VITAMIN B12 AND FOLIC ACID
Folic acid and derivatives
ATC B03BB51 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
VITAMIN B12 AND FOLIC ACID
Folic acid and derivatives
ATC V04CX02 VARIOUS
DIAGNOSTIC AGENTS
OTHER DIAGNOSTIC AGENTS
Other diagnostic agents
MeSH PA D006397 Hematinics
MeSH PA D006401 Hematologic Agents
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
MeSH PA D018977 Micronutrients
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:33231 antitubercular agent
CHEBI has role CHEBI:33284 nutrient
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35623 anticonvulsant
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:38068 antimalarial
CHEBI has role CHEBI:48407 antiparkinson drug
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:50247 antidote
CHEBI has role CHEBI:50646 bone density conservation agent
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:75771 mouse metabolite
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:77746 human metabolite
CHEBI has role CHEBI:145947 antiatherosclerotic agent
CHEBI has role CHEBI:231911 renoprotective agent

Related Drugs by ATC class:

B03AD Iron in combination with folic acid 3 drugs
ferrous fumarateferrous gluconateferrous sulfate
B03AE Iron in other combinations 2 drugs
cyanocobalaminiron
V04CX Other diagnostic agents 9 drugs
5-aminolevulinic acid hexyl esteredrophoniumindocyanine greenmannitolmethacholinepafolacianinepegulicianineUREA C-13xenon

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Megaloblastic anemia due to folate deficiency indication 85649008 DOID:14026
Vitamin deficiency indication 85670002
Iron deficiency anemia indication 87522002
Mineral deficiency indication 111379007
Folic acid deficiency indication 190633005
Pregnancy, function indication 289908002
Breastfeeding (mother) indication 413712001
Vitamin Deficiency Prevention indication
Mineral Deficiency Prevention indication
Prevention of Vitamin B12 Deficiency indication
Homocystinuria off-label use 11282001 DOID:9263
Homocystinemia off-label use 52311001
Prevention of Fetal Neural Tube Defects during Pregnancy off-label use
Peptic ulcer contraindication 13200003 DOID:750
Bipolar disorder contraindication 13746004 DOID:3312
Constipation contraindication 14760008 DOID:2089
Operation on stomach contraindication 16453004
Primary hyperoxaluria contraindication 17901006 DOID:2977
Gastroenteritis contraindication 25374005 DOID:2326
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Hemosiderosis contraindication 39011001 DOID:12119
Hypokalemia contraindication 43339004
Gastrectomy contraindication 53442002
Leber's optic atrophy contraindication 58610003 DOID:705
Hemolytic anemia contraindication 61261009 DOID:583
Diarrhea contraindication 62315008
Ulcerative colitis contraindication 64766004 DOID:8577
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Diabetes mellitus contraindication 73211009 DOID:9351
Phototoxicity contraindication 84326006
Atrophic gastritis contraindication 84568007 DOID:8929
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Anemia due to enzyme deficiency contraindication 111577008
Hb SS disease contraindication 127040003 DOID:10923
Osteolysis contraindication 203522001
Hypomania contraindication 231496004
Esophageal dysmotility contraindication 266434009 DOID:9192
Diverticular disease contraindication 397881000
Hemochromatosis contraindication 399187006 DOID:2352
Repeated Blood Transfusions contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.46 acidic
pKa2 5.15 acidic
pKa3 12.96 acidic
pKa4 4.55 Basic
pKa5 4.15 Basic
pKa6 2.28 Basic
pKa7 1.73 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;30MCG/ML MULTIPLE VITAMINS INJECTION ADULT APOTEX A210672 April 9, 2026 RX SOLUTION INTRAVENOUS Dec. 1, 2026 COMPETITIVE GENERIC THERAPY
80MG/VIAL;0.02MG/VIAL;400 IU/VIAL;0.001MG/VIAL;5MG/VIAL;0.14MG/VIAL;17MG/VIAL;1MG/VIAL;1.4MG/VIAL;1.2MG/VIAL;7 IU/VIAL;2,300 IU/VIAL;0.2MG/VIAL MULTIPLE VITAMINS INJECTION PEDIATRIC APOTEX A210671 April 21, 2026 RX INJECTABLE INTRAVENOUS Dec. 21, 2026 COMPETITIVE GENERIC THERAPY

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Thymidylate synthase Enzyme Ki 4.40 CHEMBL
Aldose reductase Enzyme IC50 4.28 CHEMBL
Dihydrofolate reductase Enzyme Kd 6.09 CHEMBL
Dihydrofolate reductase Enzyme Kd 6.09 CHEMBL

External reference:

IDSource
4017507 VUID
N0000145892 NUI
D00070 KEGG_DRUG
6484-89-5 SECONDARY_CAS_RN
4017507 VANDF
C0016410 UMLSCUI
CHEBI:27470 CHEBI
FA PDB_CHEM_ID
CHEMBL1622 ChEMBL_ID
CHEMBL2107429 ChEMBL_ID
D005492 MESH_DESCRIPTOR_UI
DB00158 DRUGBANK_ID
4563 IUPHAR_LIGAND_ID
68 INN_ID
935E97BOY8 UNII
135398658 PUBCHEM_CID
1300473 RXNORM
264 MMSL
4759 MMSL
d00241 MMSL
001049 NDDF
126224002 SNOMEDCT_US
6247001 SNOMEDCT_US
63718003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ferralet 90 HUMAN PRESCRIPTION DRUG LABEL 5 0178-0089 TABLET, FILM COATED 1 mg ORAL unapproved drug other 17 sections
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 1 mg ORAL Unapproved drug other 12 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0798 CAPSULE, GELATIN COATED 1 mg ORAL UNAPPROVED DRUG OTHER 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0799 CAPSULE, GELATIN COATED 1 mg ORAL Unapproved drug other 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0812 CAPSULE, GELATIN COATED 1 mg ORAL Unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 1 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 1 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 1 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 1 mg ORAL Unapproved drug other 9 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 1 mg ORAL Unapproved drug other 11 sections
Folic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0615-8589 TABLET 1 mg ORAL ANDA 16 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 1700 ug ORAL unapproved drug other 14 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 0.40 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol OBCaplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 1 mg ORAL unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 1 mg ORAL UNAPPROVED DRUG OTHER 13 sections
VitafolUltra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 680 ug ORAL unapproved drug other 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 0.40 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Strovite OneCaplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 1700 ug ORAL unapproved drug other 14 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 16 0642-3010 CAPSULE, GELATIN COATED 1 mg ORAL unapproved drug other 7 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 680 mg ORAL unapproved drug other 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 1000 ug ORAL UNAPPROVED DRUG OTHER 4 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 1 mg ORAL UNAPPROVED DRUG OTHER 10 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 16 0813-0202 TABLET 1 mg ORAL UNAPPROVED DRUG OTHER 6 sections
Folic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0904-7224 TABLET 1 mg ORAL ANDA 11 sections
Folic Acid HUMAN PRESCRIPTION DRUG LABEL 1 10135-182 TABLET 1 mg ORAL ANDA 17 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 3 mg ORAL Unapproved drug other 7 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 9 10542-010 TABLET, COATED 1 mg ORAL Unapproved drug other 7 sections
Dialyvite 5000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-011 TABLET, COATED 5 mg ORAL Unapproved drug other 7 sections
Dialyvite with Zinc HUMAN PRESCRIPTION DRUG LABEL 10 10542-012 TABLET, COATED 1 mg ORAL Unapproved drug other 7 sections
Dialyvite 3000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-014 TABLET, COATED 3 mg ORAL Unapproved drug other 7 sections