Stem definition | Drug id | CAS RN |
---|---|---|
1231 | 59-30-3 |
Dose | Unit | Route |
---|---|---|
0.40 | mg | O |
10 | mg | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.00 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 11.43 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 75 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 9.70 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 52 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.50 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 2.60 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Aug. 13, 1946 | FDA | LEDERLE |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Rheumatoid arthritis | 1020.67 | 9.73 | 3750 | 311697 | 236465 | 46134150 |
Pemphigus | 871.03 | 9.73 | 1288 | 314159 | 43986 | 46326629 |
Systemic lupus erythematosus | 745.12 | 9.73 | 1471 | 313976 | 63709 | 46306906 |
Completed suicide | 729.48 | 9.73 | 71 | 315376 | 145849 | 46224766 |
Maternal exposure during pregnancy | 621.88 | 9.73 | 1809 | 313638 | 100740 | 46269875 |
Glossodynia | 562.99 | 9.73 | 1047 | 314400 | 43326 | 46327289 |
Exposure during pregnancy | 455.23 | 9.73 | 1686 | 313761 | 106526 | 46264089 |
Hand deformity | 420.12 | 9.73 | 801 | 314646 | 33773 | 46336842 |
Toxicity to various agents | 381.79 | 9.73 | 524 | 314923 | 211242 | 46159373 |
Death | 346.16 | 9.73 | 1139 | 314308 | 334409 | 46036206 |
Arthropathy | 329.11 | 9.73 | 1287 | 314160 | 83413 | 46287202 |
Alopecia | 324.26 | 9.73 | 2041 | 313406 | 160373 | 46210242 |
Gestational diabetes | 315.88 | 9.73 | 312 | 315135 | 6907 | 46363708 |
Infusion related reaction | 308.17 | 9.73 | 1428 | 314019 | 99780 | 46270835 |
Abdominal discomfort | 292.02 | 9.73 | 1884 | 313563 | 149281 | 46221334 |
Joint swelling | 285.62 | 9.73 | 2011 | 313436 | 164062 | 46206553 |
Foetal exposure during pregnancy | 281.40 | 9.73 | 634 | 314813 | 30113 | 46340502 |
Drug abuse | 280.02 | 9.73 | 46 | 315401 | 63362 | 46307253 |
Wound | 267.74 | 9.73 | 764 | 314683 | 42038 | 46328577 |
Pain | 260.11 | 9.73 | 4593 | 310854 | 472355 | 45898260 |
Arthralgia | 250.71 | 9.73 | 3650 | 311797 | 360953 | 46009662 |
Intentional overdose | 238.71 | 9.73 | 71 | 315376 | 64873 | 46305742 |
Synovitis | 225.07 | 9.73 | 913 | 314534 | 60162 | 46310453 |
Drug hypersensitivity | 203.01 | 9.73 | 902 | 314545 | 242923 | 46127692 |
Anti-cyclic citrullinated peptide antibody positive | 200.59 | 9.73 | 417 | 315030 | 18728 | 46351887 |
Small for dates baby | 197.09 | 9.73 | 177 | 315270 | 3460 | 46367155 |
Contraindicated product administered | 194.50 | 9.73 | 1059 | 314388 | 78888 | 46291727 |
Pericarditis | 192.33 | 9.73 | 469 | 314978 | 23458 | 46347157 |
Overdose | 171.11 | 9.73 | 265 | 315182 | 101714 | 46268901 |
Rheumatoid factor positive | 169.74 | 9.73 | 406 | 315041 | 20055 | 46350560 |
Swelling | 167.26 | 9.73 | 1424 | 314023 | 123087 | 46247528 |
Suicide attempt | 160.08 | 9.73 | 86 | 315361 | 54950 | 46315665 |
Hip arthroplasty | 159.63 | 9.73 | 368 | 315079 | 17744 | 46352871 |
Nasopharyngitis | 157.45 | 9.73 | 1662 | 313785 | 152336 | 46218279 |
Abortion spontaneous | 155.66 | 9.73 | 646 | 314801 | 43000 | 46327615 |
Product use issue | 154.33 | 9.73 | 1132 | 314315 | 93512 | 46277103 |
Cardiac arrest | 152.52 | 9.73 | 234 | 315213 | 90165 | 46280450 |
Pregnancy | 146.58 | 9.73 | 460 | 314987 | 26677 | 46343938 |
Knee arthroplasty | 142.72 | 9.73 | 417 | 315030 | 23248 | 46347367 |
Red blood cell sedimentation rate abnormal | 142.64 | 9.73 | 297 | 315150 | 13352 | 46357263 |
Febrile neutropenia | 138.57 | 9.73 | 268 | 315179 | 94359 | 46276256 |
Sickle cell anaemia with crisis | 134.37 | 9.73 | 150 | 315297 | 3842 | 46366773 |
Musculoskeletal stiffness | 133.82 | 9.73 | 1125 | 314322 | 96868 | 46273747 |
C-reactive protein abnormal | 133.29 | 9.73 | 380 | 315067 | 20890 | 46349725 |
Drug interaction | 131.04 | 9.73 | 819 | 314628 | 202275 | 46168340 |
Discomfort | 117.37 | 9.73 | 624 | 314823 | 46046 | 46324569 |
Injection site erythema | 117.21 | 9.73 | 883 | 314564 | 73544 | 46297071 |
Device expulsion | 117.16 | 9.73 | 22 | 315425 | 27520 | 46343095 |
Malignant neoplasm progression | 115.43 | 9.73 | 162 | 315285 | 64764 | 46305851 |
Depressed level of consciousness | 105.91 | 9.73 | 99 | 315348 | 47470 | 46323145 |
Respiratory arrest | 101.06 | 9.73 | 51 | 315396 | 33765 | 46336850 |
Disease progression | 100.78 | 9.73 | 300 | 315147 | 91000 | 46279615 |
Atrial septal defect | 97.83 | 9.73 | 163 | 315284 | 6169 | 46364446 |
Injection site pruritus | 97.63 | 9.73 | 528 | 314919 | 39215 | 46331400 |
Injection site pain | 97.32 | 9.73 | 1130 | 314317 | 106022 | 46264593 |
Caesarean section | 95.77 | 9.73 | 288 | 315159 | 16315 | 46354300 |
Bradycardia | 91.71 | 9.73 | 194 | 315253 | 66104 | 46304511 |
Anxiety | 89.90 | 9.73 | 791 | 314656 | 181166 | 46189449 |
Arthritis | 89.30 | 9.73 | 856 | 314591 | 76460 | 46294155 |
Blood pressure fluctuation | 87.71 | 9.73 | 423 | 315024 | 30025 | 46340590 |
Basal cell carcinoma | 85.80 | 9.73 | 319 | 315128 | 20168 | 46350447 |
Psoriatic arthropathy | 85.80 | 9.73 | 478 | 314969 | 35901 | 46334714 |
Acute kidney injury | 84.76 | 9.73 | 1104 | 314343 | 234751 | 46135864 |
Dyspnoea | 84.39 | 9.73 | 2749 | 312698 | 512799 | 45857816 |
Respiratory disorder neonatal | 81.79 | 9.73 | 60 | 315387 | 868 | 46369747 |
Agitation | 81.05 | 9.73 | 157 | 315290 | 55258 | 46315357 |
Ventricular septal defect | 80.72 | 9.73 | 117 | 315330 | 3917 | 46366698 |
Injection site swelling | 80.39 | 9.73 | 507 | 314940 | 39820 | 46330795 |
Therapeutic product effect decreased | 79.91 | 9.73 | 882 | 314565 | 81719 | 46288896 |
Pancytopenia | 78.10 | 9.73 | 899 | 314548 | 84159 | 46286456 |
Cardio-respiratory arrest | 78.04 | 9.73 | 181 | 315266 | 59688 | 46310927 |
Duodenal ulcer perforation | 76.30 | 9.73 | 174 | 315273 | 8328 | 46362287 |
Pre-eclampsia | 75.54 | 9.73 | 167 | 315280 | 7827 | 46362788 |
Premature delivery | 75.05 | 9.73 | 322 | 315125 | 21747 | 46348868 |
Dizziness | 74.74 | 9.73 | 1741 | 313706 | 338673 | 46031942 |
Injection site reaction | 74.36 | 9.73 | 566 | 314881 | 47283 | 46323332 |
Nausea | 74.06 | 9.73 | 3846 | 311601 | 683608 | 45687007 |
Osteoarthritis | 73.75 | 9.73 | 691 | 314756 | 61334 | 46309281 |
Electrocardiogram QT prolonged | 72.83 | 9.73 | 148 | 315299 | 51177 | 46319438 |
Live birth | 72.11 | 9.73 | 192 | 315255 | 10138 | 46360477 |
Tremor | 71.59 | 9.73 | 472 | 314975 | 115167 | 46255448 |
Asthma | 70.50 | 9.73 | 348 | 315099 | 91194 | 46279421 |
Product quality issue | 69.48 | 9.73 | 83 | 315364 | 35565 | 46335050 |
Helicobacter infection | 69.03 | 9.73 | 205 | 315242 | 11531 | 46359084 |
Premature labour | 68.98 | 9.73 | 200 | 315247 | 11099 | 46359516 |
Cardiac failure | 67.43 | 9.73 | 294 | 315153 | 79654 | 46290961 |
Drug withdrawal syndrome | 67.05 | 9.73 | 52 | 315395 | 27332 | 46343283 |
Disability assessment scale score increased | 66.91 | 9.73 | 79 | 315368 | 2153 | 46368462 |
Joint effusion | 66.31 | 9.73 | 205 | 315242 | 11790 | 46358825 |
Lactic acidosis | 66.03 | 9.73 | 79 | 315368 | 33830 | 46336785 |
Drug dependence | 64.14 | 9.73 | 27 | 315420 | 19874 | 46350741 |
Multiple sclerosis relapse | 63.66 | 9.73 | 117 | 315330 | 42008 | 46328607 |
Insomnia | 63.31 | 9.73 | 761 | 314686 | 164163 | 46206452 |
Intentional self-injury | 62.93 | 9.73 | 43 | 315404 | 24123 | 46346492 |
Rhabdomyolysis | 62.80 | 9.73 | 117 | 315330 | 41792 | 46328823 |
Sedation | 59.35 | 9.73 | 41 | 315406 | 22869 | 46347746 |
Joint laxity | 57.63 | 9.73 | 71 | 315376 | 2025 | 46368590 |
Impaired healing | 57.29 | 9.73 | 435 | 315012 | 36308 | 46334307 |
Constipation | 56.73 | 9.73 | 831 | 314616 | 173266 | 46197349 |
Renal failure | 55.97 | 9.73 | 494 | 314953 | 113100 | 46257515 |
Somnolence | 54.21 | 9.73 | 738 | 314709 | 155783 | 46214832 |
Maternal drugs affecting foetus | 52.96 | 9.73 | 116 | 315331 | 5402 | 46365213 |
Red blood cell sedimentation rate increased | 52.80 | 9.73 | 299 | 315148 | 22590 | 46348025 |
Intentional product misuse | 51.88 | 9.73 | 155 | 315292 | 46973 | 46323642 |
Localised infection | 51.71 | 9.73 | 306 | 315141 | 23495 | 46347120 |
Neck deformity | 51.29 | 9.73 | 63 | 315384 | 1791 | 46368824 |
Premature rupture of membranes | 50.67 | 9.73 | 100 | 315347 | 4323 | 46366292 |
Drug reaction with eosinophilia and systemic symptoms | 50.27 | 9.73 | 76 | 315371 | 29472 | 46341143 |
Blood pressure diastolic abnormal | 50.17 | 9.73 | 123 | 315324 | 6171 | 46364444 |
Confusional state | 50.08 | 9.73 | 769 | 314678 | 159123 | 46211492 |
Diarrhoea | 50.07 | 9.73 | 3186 | 312261 | 556416 | 45814199 |
Tachycardia | 50.07 | 9.73 | 431 | 315016 | 99191 | 46271424 |
Palmar-plantar erythrodysaesthesia syndrome | 49.86 | 9.73 | 39 | 315408 | 20412 | 46350203 |
Psoriasis | 49.83 | 9.73 | 777 | 314670 | 77827 | 46292788 |
Lower respiratory tract infection | 48.66 | 9.73 | 578 | 314869 | 54511 | 46316104 |
Dysmorphism | 48.30 | 9.73 | 62 | 315385 | 1845 | 46368770 |
Foetal death | 47.93 | 9.73 | 149 | 315298 | 8594 | 46362021 |
Hypotension | 47.81 | 9.73 | 1201 | 314246 | 231388 | 46139227 |
Neuropathy peripheral | 47.59 | 9.73 | 389 | 315058 | 90504 | 46280111 |
Talipes | 47.58 | 9.73 | 53 | 315394 | 1354 | 46369261 |
Myalgia | 47.58 | 9.73 | 567 | 314880 | 122521 | 46248094 |
Drug ineffective | 47.50 | 9.73 | 5250 | 310197 | 672588 | 45698027 |
Treatment failure | 47.34 | 9.73 | 888 | 314559 | 92199 | 46278416 |
Herpes zoster | 47.33 | 9.73 | 682 | 314765 | 67190 | 46303425 |
Hepatic enzyme increased | 47.20 | 9.73 | 796 | 314651 | 80991 | 46289624 |
Congenital umbilical hernia | 46.93 | 9.73 | 33 | 315414 | 445 | 46370170 |
Sopor | 46.86 | 9.73 | 39 | 315408 | 19789 | 46350826 |
Hyperhidrosis | 46.86 | 9.73 | 382 | 315065 | 88926 | 46281689 |
Juvenile idiopathic arthritis | 46.83 | 9.73 | 93 | 315354 | 4039 | 46366576 |
Tuberculosis | 46.51 | 9.73 | 164 | 315283 | 10101 | 46360514 |
Developmental hip dysplasia | 46.29 | 9.73 | 50 | 315397 | 1233 | 46369382 |
Hepatic failure | 46.02 | 9.73 | 98 | 315349 | 33318 | 46337297 |
Neutropenia | 45.78 | 9.73 | 686 | 314761 | 142518 | 46228097 |
Hyponatraemia | 45.48 | 9.73 | 451 | 314996 | 100881 | 46269734 |
Neoplasm progression | 45.04 | 9.73 | 69 | 315378 | 26614 | 46344001 |
Injection site bruising | 44.36 | 9.73 | 401 | 315046 | 35235 | 46335380 |
Cardiac failure congestive | 44.31 | 9.73 | 401 | 315046 | 91349 | 46279266 |
Rheumatoid nodule | 44.27 | 9.73 | 148 | 315299 | 8872 | 46361743 |
Malignant melanoma | 44.23 | 9.73 | 161 | 315286 | 10073 | 46360542 |
Osteoporosis | 44.13 | 9.73 | 444 | 315003 | 40164 | 46330451 |
Injection site rash | 43.61 | 9.73 | 217 | 315230 | 15596 | 46355019 |
Pulmonary arterial hypertension | 42.86 | 9.73 | 68 | 315379 | 25860 | 46344755 |
Premature baby | 42.71 | 9.73 | 238 | 315209 | 17874 | 46352741 |
Drug resistance | 42.50 | 9.73 | 33 | 315414 | 17335 | 46353280 |
Foot deformity | 42.07 | 9.73 | 211 | 315236 | 15214 | 46355401 |
Coma | 41.98 | 9.73 | 227 | 315220 | 58122 | 46312493 |
Poisoning | 41.97 | 9.73 | 21 | 315426 | 13973 | 46356642 |
Urticaria | 41.84 | 9.73 | 553 | 314894 | 117339 | 46253276 |
Therapeutic response decreased | 41.84 | 9.73 | 461 | 314986 | 42684 | 46327931 |
Loss of personal independence in daily activities | 41.64 | 9.73 | 579 | 314868 | 56604 | 46314011 |
Vomiting | 41.63 | 9.73 | 2571 | 312876 | 450223 | 45920392 |
Sinusitis | 41.32 | 9.73 | 1159 | 314288 | 128609 | 46242006 |
Infective pulmonary exacerbation of cystic fibrosis | 41.21 | 9.73 | 11 | 315436 | 10796 | 46359819 |
Hypoglycaemia | 40.46 | 9.73 | 209 | 315238 | 54140 | 46316475 |
Asthenia | 39.70 | 9.73 | 1708 | 313739 | 309367 | 46061248 |
Depression | 39.49 | 9.73 | 862 | 314585 | 169242 | 46201373 |
Skin ulcer | 39.26 | 9.73 | 363 | 315084 | 32095 | 46338520 |
Blood pressure systolic abnormal | 38.97 | 9.73 | 103 | 315344 | 5414 | 46365201 |
Cytomegalovirus infection | 38.94 | 9.73 | 39 | 315408 | 18105 | 46352510 |
Hyperglycaemia | 38.85 | 9.73 | 115 | 315332 | 34956 | 46335659 |
Oropharyngeal pain | 38.56 | 9.73 | 710 | 314737 | 73458 | 46297157 |
Blood glucose increased | 38.24 | 9.73 | 307 | 315140 | 71706 | 46298909 |
Hypoxia | 38.22 | 9.73 | 200 | 315247 | 51638 | 46318977 |
Diabetic ketoacidosis | 38.11 | 9.73 | 40 | 315407 | 18170 | 46352445 |
Plasma cell myeloma | 37.84 | 9.73 | 163 | 315284 | 44315 | 46326300 |
Emotional distress | 37.51 | 9.73 | 96 | 315351 | 30611 | 46340004 |
Pulmonary tuberculosis | 37.23 | 9.73 | 92 | 315355 | 4639 | 46365976 |
Condition aggravated | 37.03 | 9.73 | 2017 | 313430 | 243035 | 46127580 |
No adverse event | 36.66 | 9.73 | 114 | 315333 | 34117 | 46336498 |
Serotonin syndrome | 35.95 | 9.73 | 68 | 315379 | 24152 | 46346463 |
Decreased appetite | 35.60 | 9.73 | 1017 | 314430 | 192819 | 46177796 |
Bone erosion | 35.42 | 9.73 | 142 | 315305 | 9301 | 46361314 |
Fluid retention | 35.41 | 9.73 | 201 | 315246 | 50845 | 46319770 |
Oral herpes | 35.11 | 9.73 | 238 | 315209 | 19152 | 46351463 |
Anaphylactic reaction | 34.79 | 9.73 | 213 | 315234 | 52899 | 46317716 |
Fracture | 34.65 | 9.73 | 210 | 315237 | 16261 | 46354354 |
Mental status changes | 34.64 | 9.73 | 136 | 315311 | 37952 | 46332663 |
Syncope | 34.54 | 9.73 | 499 | 314948 | 104304 | 46266311 |
Mydriasis | 34.52 | 9.73 | 14 | 315433 | 10539 | 46360076 |
Respiratory failure | 34.28 | 9.73 | 443 | 315004 | 94373 | 46276242 |
Renal impairment | 34.21 | 9.73 | 329 | 315118 | 74043 | 46296572 |
Limb deformity | 34.12 | 9.73 | 75 | 315372 | 3501 | 46367114 |
Neutrophil count decreased | 33.46 | 9.73 | 165 | 315282 | 43261 | 46327354 |
Myocardial infarction | 32.97 | 9.73 | 462 | 314985 | 97066 | 46273549 |
Hallucination | 32.88 | 9.73 | 200 | 315247 | 49751 | 46320864 |
Blood creatine phosphokinase increased | 32.86 | 9.73 | 88 | 315359 | 27636 | 46342979 |
Feeling abnormal | 32.81 | 9.73 | 621 | 314826 | 124439 | 46246176 |
Inflammation | 32.76 | 9.73 | 487 | 314960 | 48294 | 46322321 |
Metastases to bone | 32.68 | 9.73 | 42 | 315405 | 17434 | 46353181 |
Arthritis infective | 32.66 | 9.73 | 92 | 315355 | 5021 | 46365594 |
Polyhydramnios | 31.61 | 9.73 | 52 | 315395 | 1947 | 46368668 |
Nodule | 31.59 | 9.73 | 197 | 315250 | 15408 | 46355207 |
Placental disorder | 31.36 | 9.73 | 43 | 315404 | 1366 | 46369249 |
Neck mass | 31.35 | 9.73 | 69 | 315378 | 3224 | 46367391 |
Metabolic acidosis | 31.25 | 9.73 | 145 | 315302 | 38635 | 46331980 |
Joint destruction | 31.23 | 9.73 | 66 | 315381 | 2998 | 46367617 |
Latent tuberculosis | 31.01 | 9.73 | 51 | 315396 | 1909 | 46368706 |
Musculoskeletal pain | 30.96 | 9.73 | 655 | 314792 | 69473 | 46301142 |
Congenital hydronephrosis | 30.96 | 9.73 | 24 | 315423 | 379 | 46370236 |
Muscle spasms | 30.87 | 9.73 | 616 | 314831 | 122497 | 46248118 |
Femur fracture | 30.85 | 9.73 | 384 | 315063 | 36613 | 46334002 |
Injection site warmth | 30.52 | 9.73 | 178 | 315269 | 13594 | 46357021 |
Polyarthritis | 30.05 | 9.73 | 105 | 315342 | 6437 | 46364178 |
Blood pressure diastolic decreased | 29.77 | 9.73 | 181 | 315266 | 14030 | 46356585 |
Ejection fraction decreased | 29.68 | 9.73 | 47 | 315400 | 17890 | 46352725 |
Grip strength decreased | 29.59 | 9.73 | 126 | 315321 | 8480 | 46362135 |
Hypotonia neonatal | 29.50 | 9.73 | 33 | 315414 | 847 | 46369768 |
Blood pressure systolic increased | 29.49 | 9.73 | 311 | 315136 | 28476 | 46342139 |
Influenza | 29.44 | 9.73 | 801 | 314646 | 88469 | 46282146 |
Shock | 29.30 | 9.73 | 65 | 315382 | 21780 | 46348835 |
Smear cervix abnormal | 28.96 | 9.73 | 57 | 315390 | 2459 | 46368156 |
Abnormal behaviour | 28.79 | 9.73 | 62 | 315385 | 20996 | 46349619 |
Hepatic function abnormal | 28.75 | 9.73 | 127 | 315320 | 34294 | 46336321 |
Ventricular tachycardia | 28.52 | 9.73 | 44 | 315403 | 16923 | 46353692 |
Respiratory depression | 28.43 | 9.73 | 22 | 315425 | 11578 | 46359037 |
Cellulitis | 28.33 | 9.73 | 648 | 314799 | 69640 | 46300975 |
Patent ductus arteriosus | 28.20 | 9.73 | 73 | 315374 | 3789 | 46366826 |
Wheezing | 28.15 | 9.73 | 228 | 315219 | 53158 | 46317457 |
Synovial cyst | 27.98 | 9.73 | 111 | 315336 | 7235 | 46363380 |
Bronchitis | 27.95 | 9.73 | 925 | 314522 | 105054 | 46265561 |
Amniotic fluid volume increased | 27.74 | 9.73 | 16 | 315431 | 149 | 46370466 |
Neonatal hypoxia | 27.19 | 9.73 | 24 | 315423 | 458 | 46370157 |
Serum ferritin increased | 27.10 | 9.73 | 88 | 315359 | 5195 | 46365420 |
Multiple fractures | 27.01 | 9.73 | 91 | 315356 | 5476 | 46365139 |
Schizophrenia | 27.01 | 9.73 | 12 | 315435 | 8556 | 46362059 |
Acute hepatic failure | 26.89 | 9.73 | 36 | 315411 | 14685 | 46355930 |
Dyspnoea exertional | 26.87 | 9.73 | 214 | 315233 | 50075 | 46320540 |
Exomphalos | 26.80 | 9.73 | 25 | 315422 | 514 | 46370101 |
Enthesopathy | 26.71 | 9.73 | 81 | 315366 | 4609 | 46366006 |
Low birth weight baby | 26.52 | 9.73 | 89 | 315358 | 5345 | 46365270 |
Foetal growth restriction | 26.45 | 9.73 | 101 | 315346 | 6466 | 46364149 |
Seizure | 26.44 | 9.73 | 631 | 314816 | 122423 | 46248192 |
Heart rate decreased | 26.33 | 9.73 | 329 | 315118 | 31394 | 46339221 |
Foetal anticonvulsant syndrome | 26.32 | 9.73 | 23 | 315424 | 433 | 46370182 |
Drug level increased | 26.30 | 9.73 | 53 | 315394 | 18388 | 46352227 |
Encephalopathy | 26.24 | 9.73 | 127 | 315320 | 33462 | 46337153 |
Agitation neonatal | 26.23 | 9.73 | 24 | 315423 | 481 | 46370134 |
Dysgeusia | 26.19 | 9.73 | 163 | 315284 | 40328 | 46330287 |
Delirium | 26.14 | 9.73 | 146 | 315301 | 37082 | 46333533 |
Neuroleptic malignant syndrome | 26.13 | 9.73 | 22 | 315425 | 11100 | 46359515 |
Pain in jaw | 26.12 | 9.73 | 152 | 315295 | 38220 | 46332395 |
Joint stiffness | 25.98 | 9.73 | 289 | 315158 | 26819 | 46343796 |
Immunosuppression | 25.94 | 9.73 | 110 | 315337 | 7390 | 46363225 |
Speech disorder | 25.85 | 9.73 | 141 | 315306 | 36026 | 46334589 |
Peripheral swelling | 25.84 | 9.73 | 1311 | 314136 | 156760 | 46213855 |
Blood pressure diastolic increased | 25.83 | 9.73 | 94 | 315353 | 5880 | 46364735 |
Angioedema | 25.65 | 9.73 | 158 | 315289 | 39184 | 46331431 |
Skin papilloma | 25.57 | 9.73 | 74 | 315373 | 4102 | 46366513 |
Restlessness | 25.26 | 9.73 | 88 | 315359 | 25436 | 46345179 |
Suicidal ideation | 25.26 | 9.73 | 251 | 315196 | 56131 | 46314484 |
Abortion late | 25.15 | 9.73 | 14 | 315433 | 121 | 46370494 |
Vision blurred | 25.05 | 9.73 | 383 | 315064 | 79325 | 46291290 |
Skin cancer | 24.99 | 9.73 | 122 | 315325 | 8701 | 46361914 |
Swollen joint count increased | 24.81 | 9.73 | 52 | 315395 | 2348 | 46368267 |
Mouth ulceration | 24.78 | 9.73 | 284 | 315163 | 26548 | 46344067 |
Tenosynovitis stenosans | 24.71 | 9.73 | 46 | 315401 | 1903 | 46368712 |
Joint range of motion decreased | 24.67 | 9.73 | 181 | 315266 | 14943 | 46355672 |
Osteonecrosis of jaw | 24.65 | 9.73 | 134 | 315313 | 34268 | 46336347 |
Fibromyalgia | 24.47 | 9.73 | 364 | 315083 | 36099 | 46334516 |
Brain oedema | 24.37 | 9.73 | 29 | 315418 | 12449 | 46358166 |
Ventricular fibrillation | 24.34 | 9.73 | 25 | 315422 | 11471 | 46359144 |
Rheumatic fever | 24.21 | 9.73 | 57 | 315390 | 2786 | 46367829 |
C-reactive protein increased | 24.19 | 9.73 | 542 | 314905 | 58048 | 46312567 |
Breast feeding | 24.15 | 9.73 | 30 | 315417 | 863 | 46369752 |
Hypothermia | 24.13 | 9.73 | 28 | 315419 | 12155 | 46358460 |
Squamous cell carcinoma | 24.12 | 9.73 | 111 | 315336 | 7725 | 46362890 |
Multiple organ dysfunction syndrome | 24.09 | 9.73 | 228 | 315219 | 51482 | 46319133 |
Muscle spasticity | 24.08 | 9.73 | 25 | 315422 | 11415 | 46359200 |
Postoperative wound infection | 24.05 | 9.73 | 120 | 315327 | 8633 | 46361982 |
Chest discomfort | 24.05 | 9.73 | 447 | 315000 | 89822 | 46280793 |
Large for dates baby | 24.04 | 9.73 | 22 | 315425 | 441 | 46370174 |
Akathisia | 24.01 | 9.73 | 11 | 315436 | 7703 | 46362912 |
Loss of consciousness | 23.82 | 9.73 | 553 | 314894 | 107685 | 46262930 |
Aspartate aminotransferase increased | 23.77 | 9.73 | 381 | 315066 | 78319 | 46292296 |
Pain in extremity | 23.77 | 9.73 | 2043 | 313404 | 256637 | 46113978 |
Palpitations | 23.47 | 9.73 | 478 | 314969 | 94781 | 46275834 |
Altered state of consciousness | 23.44 | 9.73 | 80 | 315367 | 23268 | 46347347 |
Blood creatinine increased | 23.37 | 9.73 | 369 | 315078 | 76034 | 46294581 |
Blood pressure decreased | 23.35 | 9.73 | 260 | 315187 | 56899 | 46313716 |
Metastases to liver | 23.33 | 9.73 | 62 | 315385 | 19523 | 46351092 |
Maternal exposure before pregnancy | 23.31 | 9.73 | 75 | 315372 | 4406 | 46366209 |
Drug intolerance | 23.30 | 9.73 | 1216 | 314231 | 145833 | 46224782 |
Extrapyramidal disorder | 23.30 | 9.73 | 25 | 315422 | 11243 | 46359372 |
Unresponsive to stimuli | 23.23 | 9.73 | 125 | 315322 | 32049 | 46338566 |
Complication of device insertion | 23.18 | 9.73 | 3 | 315444 | 4941 | 46365674 |
Product use in unapproved indication | 23.13 | 9.73 | 450 | 314997 | 89823 | 46280792 |
Normal newborn | 23.12 | 9.73 | 91 | 315356 | 5910 | 46364705 |
Balance disorder | 23.12 | 9.73 | 302 | 315145 | 64219 | 46306396 |
Induced labour | 23.08 | 9.73 | 30 | 315417 | 904 | 46369711 |
Stillbirth | 23.07 | 9.73 | 96 | 315351 | 6395 | 46364220 |
Pulmonary embolism | 23.00 | 9.73 | 558 | 314889 | 108027 | 46262588 |
Posterior reversible encephalopathy syndrome | 22.92 | 9.73 | 42 | 315405 | 15099 | 46355516 |
Dysarthria | 22.71 | 9.73 | 154 | 315293 | 37344 | 46333271 |
Abortion missed | 22.35 | 9.73 | 39 | 315408 | 1533 | 46369082 |
Arthritis bacterial | 22.11 | 9.73 | 87 | 315360 | 5649 | 46364966 |
Tenderness | 22.06 | 9.73 | 192 | 315255 | 16689 | 46353926 |
Oligohydramnios | 21.97 | 9.73 | 84 | 315363 | 5381 | 46365234 |
Acute chest syndrome | 21.96 | 9.73 | 23 | 315424 | 547 | 46370068 |
Torsade de pointes | 21.92 | 9.73 | 30 | 315417 | 12124 | 46358491 |
Memory impairment | 21.85 | 9.73 | 379 | 315068 | 76958 | 46293657 |
Psychotic disorder | 21.72 | 9.73 | 79 | 315368 | 22542 | 46348073 |
Neurotoxicity | 21.71 | 9.73 | 37 | 315410 | 13680 | 46356935 |
Device dislocation | 21.69 | 9.73 | 75 | 315372 | 21727 | 46348888 |
Cholestasis of pregnancy | 21.62 | 9.73 | 32 | 315415 | 1092 | 46369523 |
Gastroenteritis viral | 21.59 | 9.73 | 202 | 315245 | 17917 | 46352698 |
Weight increased | 21.59 | 9.73 | 1337 | 314110 | 163136 | 46207479 |
Placental insufficiency | 21.56 | 9.73 | 35 | 315412 | 1296 | 46369319 |
Haemorrhage in pregnancy | 21.36 | 9.73 | 39 | 315408 | 1589 | 46369026 |
Cerebral haemorrhage neonatal | 21.18 | 9.73 | 13 | 315434 | 137 | 46370478 |
Product adhesion issue | 20.98 | 9.73 | 4 | 315443 | 4951 | 46365664 |
Blood bilirubin increased | 20.89 | 9.73 | 140 | 315307 | 34044 | 46336571 |
Maternal exposure during breast feeding | 20.65 | 9.73 | 53 | 315394 | 2736 | 46367879 |
Synovial fluid analysis | 20.64 | 9.73 | 35 | 315412 | 1344 | 46369271 |
Alanine aminotransferase increased | 20.57 | 9.73 | 448 | 314999 | 88003 | 46282612 |
Oedema | 20.49 | 9.73 | 324 | 315123 | 66747 | 46303868 |
Twin pregnancy | 20.42 | 9.73 | 32 | 315415 | 1149 | 46369466 |
Respiratory disorder | 20.31 | 9.73 | 105 | 315342 | 27195 | 46343420 |
Scleritis | 20.20 | 9.73 | 54 | 315393 | 2858 | 46367757 |
Fear | 20.19 | 9.73 | 50 | 315397 | 16122 | 46354493 |
Transplant rejection | 20.17 | 9.73 | 21 | 315426 | 9575 | 46361040 |
White blood cell count decreased | 20.03 | 9.73 | 591 | 314856 | 111640 | 46258975 |
Birth mark | 19.94 | 9.73 | 15 | 315432 | 226 | 46370389 |
Disturbance in attention | 19.92 | 9.73 | 128 | 315319 | 31432 | 46339183 |
Clear cell renal cell carcinoma | 19.59 | 9.73 | 29 | 315418 | 990 | 46369625 |
Graft versus host disease | 19.58 | 9.73 | 10 | 315437 | 6578 | 46364037 |
Cerebrovascular accident | 19.58 | 9.73 | 526 | 314921 | 100513 | 46270102 |
Surgery | 19.57 | 9.73 | 288 | 315159 | 28497 | 46342118 |
Contusion | 19.46 | 9.73 | 749 | 314698 | 86738 | 46283877 |
Ascites | 19.40 | 9.73 | 156 | 315291 | 36428 | 46334187 |
Anaphylactic shock | 19.33 | 9.73 | 71 | 315376 | 20203 | 46350412 |
Mania | 19.33 | 9.73 | 27 | 315420 | 10819 | 46359796 |
Injury | 19.30 | 9.73 | 197 | 315250 | 43830 | 46326785 |
Abortion threatened | 19.26 | 9.73 | 22 | 315425 | 578 | 46370037 |
Immunodeficiency | 19.23 | 9.73 | 153 | 315294 | 12953 | 46357662 |
Gestational hypertension | 19.22 | 9.73 | 44 | 315403 | 2111 | 46368504 |
Bradyphrenia | 19.21 | 9.73 | 9 | 315438 | 6221 | 46364394 |
Body height below normal | 19.19 | 9.73 | 40 | 315407 | 1799 | 46368816 |
Injection site haematoma | 19.13 | 9.73 | 87 | 315360 | 6025 | 46364590 |
Hospitalisation | 19.09 | 9.73 | 307 | 315140 | 63078 | 46307537 |
Disorientation | 18.86 | 9.73 | 159 | 315288 | 36759 | 46333856 |
Loose body in joint | 18.80 | 9.73 | 29 | 315418 | 1027 | 46369588 |
Blood alkaline phosphatase increased | 18.73 | 9.73 | 174 | 315273 | 39435 | 46331180 |
Bronchioloalveolar carcinoma | 18.71 | 9.73 | 10 | 315437 | 79 | 46370536 |
Antinuclear antibody positive | 18.63 | 9.73 | 88 | 315359 | 6192 | 46364423 |
Neonatal respiratory distress syndrome | 18.62 | 9.73 | 48 | 315399 | 2485 | 46368130 |
Haemorrhage | 18.51 | 9.73 | 260 | 315187 | 54609 | 46316006 |
Bronchospasm | 18.50 | 9.73 | 50 | 315397 | 15657 | 46354958 |
Diverticulitis | 18.48 | 9.73 | 320 | 315127 | 32719 | 46337896 |
Substance abuse | 18.44 | 9.73 | 3 | 315444 | 4164 | 46366451 |
Fluid overload | 18.34 | 9.73 | 108 | 315339 | 27077 | 46343538 |
Platelet count decreased | 18.28 | 9.73 | 525 | 314922 | 99499 | 46271116 |
Arrhythmia | 18.27 | 9.73 | 149 | 315298 | 34692 | 46335923 |
Congenital arterial malformation | 18.21 | 9.73 | 17 | 315430 | 350 | 46370265 |
Breast cancer metastatic | 18.10 | 9.73 | 41 | 315406 | 13637 | 46356978 |
Atrioventricular block complete | 18.02 | 9.73 | 15 | 315432 | 7612 | 46363003 |
Metastases to central nervous system | 18.01 | 9.73 | 30 | 315417 | 11191 | 46359424 |
Cushingoid | 18.00 | 9.73 | 87 | 315360 | 6179 | 46364436 |
Nightmare | 17.97 | 9.73 | 55 | 315392 | 16543 | 46354072 |
Disability | 17.93 | 9.73 | 124 | 315323 | 10043 | 46360572 |
Foetal distress syndrome | 17.70 | 9.73 | 31 | 315416 | 1222 | 46369393 |
Hypomania | 17.64 | 9.73 | 4 | 315443 | 4384 | 46366231 |
Acute graft versus host disease | 17.61 | 9.73 | 3 | 315444 | 4027 | 46366588 |
Multiple sclerosis | 17.52 | 9.73 | 97 | 315350 | 24694 | 46345921 |
Foot fracture | 17.52 | 9.73 | 206 | 315241 | 19376 | 46351239 |
Device difficult to use | 17.41 | 9.73 | 17 | 315430 | 7987 | 46362628 |
Inappropriate antidiuretic hormone secretion | 17.29 | 9.73 | 44 | 315403 | 14058 | 46356557 |
Anaemia macrocytic | 17.21 | 9.73 | 48 | 315399 | 2605 | 46368010 |
Joint noise | 17.18 | 9.73 | 54 | 315393 | 3133 | 46367482 |
Failed induction of labour | 17.15 | 9.73 | 16 | 315431 | 329 | 46370286 |
B-cell lymphoma | 17.02 | 9.73 | 55 | 315392 | 3239 | 46367376 |
Irritability | 16.97 | 9.73 | 120 | 315327 | 28826 | 46341789 |
Fatigue | 16.93 | 9.73 | 4489 | 310958 | 604208 | 45766407 |
Antibody test positive | 16.93 | 9.73 | 42 | 315405 | 2123 | 46368492 |
Cholecystitis chronic | 16.91 | 9.73 | 28 | 315419 | 10471 | 46360144 |
Lymphoma | 16.91 | 9.73 | 119 | 315328 | 9694 | 46360921 |
Hypokalaemia | 16.86 | 9.73 | 459 | 314988 | 87565 | 46283050 |
Coagulopathy | 16.85 | 9.73 | 66 | 315381 | 18433 | 46352182 |
Venoocclusive liver disease | 16.84 | 9.73 | 4 | 315443 | 4247 | 46366368 |
Febrile bone marrow aplasia | 16.84 | 9.73 | 13 | 315434 | 6849 | 46363766 |
Complication associated with device | 16.83 | 9.73 | 51 | 315396 | 15390 | 46355225 |
Product administration error | 16.81 | 9.73 | 72 | 315375 | 19609 | 46351006 |
Autoimmune haemolytic anaemia | 16.75 | 9.73 | 65 | 315382 | 4193 | 46366422 |
Fracture delayed union | 16.71 | 9.73 | 42 | 315405 | 2140 | 46368475 |
Aggression | 16.62 | 9.73 | 88 | 315359 | 22656 | 46347959 |
Post transplant lymphoproliferative disorder | 16.57 | 9.73 | 3 | 315444 | 3853 | 46366762 |
Erythema multiforme | 16.47 | 9.73 | 25 | 315422 | 9679 | 46360936 |
Wheelchair user | 16.44 | 9.73 | 62 | 315385 | 3946 | 46366669 |
Injection site haemorrhage | 16.43 | 9.73 | 213 | 315234 | 20496 | 46350119 |
Blood iron increased | 16.36 | 9.73 | 31 | 315416 | 1300 | 46369315 |
Chest pain | 16.33 | 9.73 | 1000 | 314447 | 175324 | 46195291 |
Poor venous access | 16.27 | 9.73 | 104 | 315343 | 8204 | 46362411 |
Anhedonia | 16.25 | 9.73 | 28 | 315419 | 10307 | 46360308 |
Synovial disorder | 16.24 | 9.73 | 24 | 315423 | 818 | 46369797 |
International normalised ratio increased | 16.22 | 9.73 | 221 | 315226 | 46662 | 46323953 |
Breech presentation | 16.20 | 9.73 | 28 | 315419 | 1092 | 46369523 |
Tumour lysis syndrome | 16.17 | 9.73 | 15 | 315432 | 7221 | 46363394 |
Disseminated tuberculosis | 16.12 | 9.73 | 48 | 315399 | 2704 | 46367911 |
Injection site urticaria | 16.10 | 9.73 | 137 | 315310 | 11830 | 46358785 |
Laryngitis | 16.07 | 9.73 | 113 | 315334 | 9203 | 46361412 |
Respiratory distress | 16.06 | 9.73 | 138 | 315309 | 31778 | 46338837 |
Congenital hypertrichosis | 16.02 | 9.73 | 4 | 315443 | 0 | 46370615 |
Cystitis | 15.96 | 9.73 | 386 | 315061 | 41855 | 46328760 |
Disseminated intravascular coagulation | 15.95 | 9.73 | 70 | 315377 | 18935 | 46351680 |
Crying | 15.90 | 9.73 | 81 | 315366 | 21060 | 46349555 |
Tonsillitis | 15.79 | 9.73 | 71 | 315376 | 4893 | 46365722 |
Injection site irritation | 15.70 | 9.73 | 64 | 315383 | 4223 | 46366392 |
Hiatus hernia | 15.70 | 9.73 | 191 | 315256 | 18111 | 46352504 |
Withdrawal syndrome | 15.70 | 9.73 | 66 | 315381 | 18068 | 46352547 |
Pulmonary fibrosis | 15.67 | 9.73 | 206 | 315241 | 19886 | 46350729 |
Hypoglycaemia neonatal | 15.65 | 9.73 | 25 | 315422 | 913 | 46369702 |
Haemoglobin decreased | 15.60 | 9.73 | 1041 | 314406 | 127908 | 46242707 |
Obstructive airways disorder | 15.57 | 9.73 | 43 | 315404 | 13369 | 46357246 |
Congenital musculoskeletal anomaly | 15.39 | 9.73 | 17 | 315430 | 430 | 46370185 |
Pulmonary hypertension | 15.39 | 9.73 | 162 | 315285 | 35831 | 46334784 |
Cervical incompetence | 15.38 | 9.73 | 20 | 315427 | 603 | 46370012 |
Status epilepticus | 15.36 | 9.73 | 46 | 315401 | 13933 | 46356682 |
Hypoplastic left heart syndrome | 15.35 | 9.73 | 12 | 315435 | 192 | 46370423 |
Preterm premature rupture of membranes | 15.32 | 9.73 | 26 | 315421 | 999 | 46369616 |
Human antichimeric antibody positive | 15.32 | 9.73 | 31 | 315416 | 1365 | 46369250 |
Drug ineffective for unapproved indication | 15.31 | 9.73 | 58 | 315389 | 16355 | 46354260 |
Tardive dyskinesia | 15.30 | 9.73 | 17 | 315430 | 7526 | 46363089 |
Lung neoplasm malignant | 15.24 | 9.73 | 166 | 315281 | 15323 | 46355292 |
Folate deficiency | 15.24 | 9.73 | 35 | 315412 | 1683 | 46368932 |
Pulmonary oedema | 15.23 | 9.73 | 248 | 315199 | 50857 | 46319758 |
Gamma-glutamyltransferase increased | 15.19 | 9.73 | 139 | 315308 | 31601 | 46339014 |
Bone pain | 15.18 | 9.73 | 224 | 315223 | 46666 | 46323949 |
Ketoacidosis | 15.13 | 9.73 | 4 | 315443 | 3951 | 46366664 |
Hyperlipidaemia | 15.12 | 9.73 | 69 | 315378 | 18470 | 46352145 |
Hyperbilirubinaemia neonatal | 15.00 | 9.73 | 15 | 315432 | 337 | 46370278 |
Dactylitis | 14.93 | 9.73 | 28 | 315419 | 1165 | 46369450 |
Glycosylated haemoglobin increased | 14.89 | 9.73 | 32 | 315415 | 10844 | 46359771 |
Mood altered | 14.88 | 9.73 | 42 | 315405 | 12965 | 46357650 |
Autism spectrum disorder | 14.86 | 9.73 | 19 | 315428 | 563 | 46370052 |
Flushing | 14.81 | 9.73 | 328 | 315119 | 64286 | 46306329 |
Haematotoxicity | 14.76 | 9.73 | 15 | 315432 | 6918 | 46363697 |
Chronic kidney disease | 14.75 | 9.73 | 191 | 315256 | 40680 | 46329935 |
Dehydration | 14.73 | 9.73 | 905 | 314542 | 158635 | 46211980 |
Post procedural infection | 14.68 | 9.73 | 94 | 315353 | 7419 | 46363196 |
Device use error | 14.68 | 9.73 | 8 | 315439 | 5073 | 46365542 |
Face oedema | 14.62 | 9.73 | 73 | 315374 | 19080 | 46351535 |
Sickle cell anaemia | 14.61 | 9.73 | 19 | 315428 | 573 | 46370042 |
Dyskinesia | 14.58 | 9.73 | 125 | 315322 | 28800 | 46341815 |
Aspergillus infection | 14.57 | 9.73 | 15 | 315432 | 6875 | 46363740 |
Congenital tricuspid valve atresia | 14.56 | 9.73 | 7 | 315440 | 43 | 46370572 |
Spinal stenosis | 14.53 | 9.73 | 139 | 315308 | 12404 | 46358211 |
Asphyxia | 14.51 | 9.73 | 9 | 315438 | 5317 | 46365298 |
Bursitis | 14.47 | 9.73 | 201 | 315246 | 19641 | 46350974 |
Complication of device removal | 14.40 | 9.73 | 3 | 315444 | 3487 | 46367128 |
Second primary malignancy | 14.30 | 9.73 | 14 | 315433 | 6570 | 46364045 |
Catheter site pain | 14.27 | 9.73 | 4 | 315443 | 3802 | 46366813 |
Pathogen resistance | 14.22 | 9.73 | 12 | 315435 | 6048 | 46364567 |
Atrioventricular block | 14.21 | 9.73 | 15 | 315432 | 6796 | 46363819 |
Pharyngitis streptococcal | 14.19 | 9.73 | 102 | 315345 | 8366 | 46362249 |
Fine motor skill dysfunction | 14.16 | 9.73 | 56 | 315391 | 3644 | 46366971 |
Muscular weakness | 14.14 | 9.73 | 493 | 314954 | 91351 | 46279264 |
Chondropathy | 14.14 | 9.73 | 37 | 315410 | 1933 | 46368682 |
Cerebral haemorrhage | 14.13 | 9.73 | 123 | 315324 | 28248 | 46342367 |
Neonatal asphyxia | 14.08 | 9.73 | 12 | 315435 | 218 | 46370397 |
Transplant dysfunction | 14.08 | 9.73 | 7 | 315440 | 4675 | 46365940 |
Tremor neonatal | 14.04 | 9.73 | 9 | 315438 | 103 | 46370512 |
Catatonia | 14.02 | 9.73 | 4 | 315443 | 3758 | 46366857 |
Impaired quality of life | 14.01 | 9.73 | 51 | 315396 | 3191 | 46367424 |
Hygroma colli | 13.98 | 9.73 | 5 | 315442 | 12 | 46370603 |
Rotator cuff repair | 13.98 | 9.73 | 31 | 315416 | 1456 | 46369159 |
Renal injury | 13.97 | 9.73 | 27 | 315420 | 9514 | 46361101 |
Joint lock | 13.96 | 9.73 | 38 | 315409 | 2033 | 46368582 |
Right aortic arch | 13.95 | 9.73 | 13 | 315434 | 267 | 46370348 |
Pancreatitis | 13.92 | 9.73 | 209 | 315238 | 43418 | 46327197 |
Haemorrhage intracranial | 13.89 | 9.73 | 42 | 315405 | 12682 | 46357933 |
Morning sickness | 13.88 | 9.73 | 20 | 315427 | 666 | 46369949 |
Cognitive disorder | 13.82 | 9.73 | 171 | 315276 | 36712 | 46333903 |
Lymphadenectomy | 13.75 | 9.73 | 23 | 315424 | 873 | 46369742 |
Lethargy | 13.75 | 9.73 | 253 | 315194 | 50918 | 46319697 |
Joint warmth | 13.74 | 9.73 | 28 | 315419 | 1239 | 46369376 |
Bone density abnormal | 13.74 | 9.73 | 49 | 315398 | 3035 | 46367580 |
Corneal degeneration | 13.73 | 9.73 | 8 | 315439 | 76 | 46370539 |
Tooth infection | 13.66 | 9.73 | 135 | 315312 | 12151 | 46358464 |
Aorta hypoplasia | 13.61 | 9.73 | 9 | 315438 | 109 | 46370506 |
Orthostatic hypotension | 13.60 | 9.73 | 104 | 315343 | 24554 | 46346061 |
Knee operation | 13.57 | 9.73 | 66 | 315381 | 4700 | 46365915 |
Cardiac failure acute | 13.52 | 9.73 | 21 | 315426 | 8057 | 46362558 |
Thrombotic microangiopathy | 13.52 | 9.73 | 22 | 315425 | 8284 | 46362331 |
Choanal atresia | 13.48 | 9.73 | 6 | 315441 | 30 | 46370585 |
Joint dislocation | 13.47 | 9.73 | 125 | 315322 | 11061 | 46359554 |
Tenosynovitis | 13.46 | 9.73 | 92 | 315355 | 7423 | 46363192 |
Acute generalised exanthematous pustulosis | 13.44 | 9.73 | 27 | 315420 | 9378 | 46361237 |
Joint injury | 13.37 | 9.73 | 193 | 315254 | 19016 | 46351599 |
Cardiogenic shock | 13.35 | 9.73 | 61 | 315386 | 16323 | 46354292 |
Complication of pregnancy | 13.34 | 9.73 | 17 | 315430 | 502 | 46370113 |
Skin laceration | 13.32 | 9.73 | 187 | 315260 | 18315 | 46352300 |
Benign congenital hypotonia | 13.27 | 9.73 | 4 | 315443 | 4 | 46370611 |
Rash | 13.26 | 9.73 | 2665 | 312782 | 353847 | 46016768 |
Wrong technique in product usage process | 13.12 | 9.73 | 274 | 315173 | 54148 | 46316467 |
Myopathy | 13.12 | 9.73 | 25 | 315422 | 8856 | 46361759 |
Ingrown hair | 13.10 | 9.73 | 16 | 315431 | 452 | 46370163 |
Pancreatic steatosis | 13.09 | 9.73 | 24 | 315423 | 981 | 46369634 |
Colitis microscopic | 13.06 | 9.73 | 15 | 315432 | 6541 | 46364074 |
Bone disorder | 13.06 | 9.73 | 199 | 315248 | 19834 | 46350781 |
Speech disorder developmental | 12.90 | 9.73 | 15 | 315432 | 402 | 46370213 |
Drug abuser | 12.89 | 9.73 | 3 | 315444 | 3230 | 46367385 |
Lupus-like syndrome | 12.87 | 9.73 | 94 | 315353 | 7750 | 46362865 |
Naevus flammeus | 12.82 | 9.73 | 9 | 315438 | 121 | 46370494 |
Unevaluable event | 12.81 | 9.73 | 227 | 315220 | 45948 | 46324667 |
Cleft lip and palate | 12.81 | 9.73 | 14 | 315433 | 350 | 46370265 |
Limb reduction defect | 12.78 | 9.73 | 14 | 315433 | 351 | 46370264 |
Cholestasis | 12.77 | 9.73 | 118 | 315329 | 26775 | 46343840 |
Hypoplastic right heart syndrome | 12.72 | 9.73 | 7 | 315440 | 59 | 46370556 |
Tendon disorder | 12.69 | 9.73 | 67 | 315380 | 4928 | 46365687 |
Infusion site erythema | 12.67 | 9.73 | 20 | 315427 | 7622 | 46362993 |
Oliguria | 12.64 | 9.73 | 25 | 315422 | 8734 | 46361881 |
Immune reconstitution inflammatory syndrome | 12.64 | 9.73 | 12 | 315435 | 5713 | 46364902 |
Eye infection | 12.57 | 9.73 | 105 | 315342 | 9018 | 46361597 |
Cyst | 12.52 | 9.73 | 131 | 315316 | 11969 | 46358646 |
Threatened labour | 12.50 | 9.73 | 21 | 315426 | 800 | 46369815 |
Papilloma viral infection | 12.44 | 9.73 | 28 | 315419 | 1328 | 46369287 |
Dysphagia | 12.37 | 9.73 | 413 | 315034 | 76899 | 46293716 |
Small cell carcinoma | 12.33 | 9.73 | 10 | 315437 | 169 | 46370446 |
Panic attack | 12.32 | 9.73 | 83 | 315364 | 20159 | 46350456 |
Polyneuropathy | 12.31 | 9.73 | 39 | 315408 | 11605 | 46359010 |
Jaundice | 12.26 | 9.73 | 130 | 315317 | 28715 | 46341900 |
Hypersensitivity | 12.22 | 9.73 | 1177 | 314270 | 149144 | 46221471 |
Wound infection pseudomonas | 12.20 | 9.73 | 29 | 315418 | 1426 | 46369189 |
Incorrect route of product administration | 12.19 | 9.73 | 63 | 315384 | 16320 | 46354295 |
Postpartum haemorrhage | 12.14 | 9.73 | 33 | 315414 | 1764 | 46368851 |
Injection site extravasation | 12.11 | 9.73 | 83 | 315364 | 6702 | 46363913 |
Anterior chamber cleavage syndrome | 12.09 | 9.73 | 10 | 315437 | 174 | 46370441 |
Parkinsonism | 12.07 | 9.73 | 22 | 315425 | 7926 | 46362689 |
Genital haemorrhage | 12.05 | 9.73 | 16 | 315431 | 6550 | 46364065 |
Infusion site pain | 12.04 | 9.73 | 32 | 315415 | 10075 | 46360540 |
Blood pressure increased | 12.02 | 9.73 | 1003 | 314444 | 125663 | 46244952 |
Congenital pulmonary artery anomaly | 12.01 | 9.73 | 3 | 315444 | 0 | 46370615 |
Double ureter | 12.01 | 9.73 | 3 | 315444 | 0 | 46370615 |
Lung neoplasm | 11.96 | 9.73 | 73 | 315374 | 5667 | 46364948 |
Gastroenteritis | 11.94 | 9.73 | 230 | 315217 | 23989 | 46346626 |
Hyperemesis gravidarum | 11.94 | 9.73 | 16 | 315431 | 497 | 46370118 |
Catheter site erythema | 11.91 | 9.73 | 6 | 315441 | 3977 | 46366638 |
Congenital cerebral cyst | 11.86 | 9.73 | 10 | 315437 | 179 | 46370436 |
Vanishing twin syndrome | 11.82 | 9.73 | 8 | 315439 | 101 | 46370514 |
Lung adenocarcinoma | 11.81 | 9.73 | 58 | 315389 | 4146 | 46366469 |
Lordosis | 11.74 | 9.73 | 12 | 315435 | 277 | 46370338 |
Pregnancy with contraceptive device | 11.74 | 9.73 | 8 | 315439 | 4495 | 46366120 |
Coronary artery disease | 11.71 | 9.73 | 159 | 315288 | 33593 | 46337022 |
Mycobacterium tuberculosis complex test positive | 11.70 | 9.73 | 30 | 315417 | 1548 | 46369067 |
Dystonia | 11.69 | 9.73 | 38 | 315409 | 11219 | 46359396 |
Injection site induration | 11.68 | 9.73 | 94 | 315353 | 7985 | 46362630 |
Forceps delivery | 11.68 | 9.73 | 10 | 315437 | 183 | 46370432 |
Paralysis | 11.66 | 9.73 | 26 | 315421 | 8695 | 46361920 |
Hypomagnesaemia | 11.64 | 9.73 | 95 | 315352 | 22115 | 46348500 |
Wound infection | 11.61 | 9.73 | 114 | 315333 | 10245 | 46360370 |
Chest X-ray abnormal | 11.56 | 9.73 | 53 | 315394 | 3682 | 46366933 |
Swollen tongue | 11.53 | 9.73 | 134 | 315313 | 29098 | 46341517 |
Body temperature decreased | 11.53 | 9.73 | 140 | 315307 | 13269 | 46357346 |
Thrombocytopenia | 11.51 | 9.73 | 719 | 314728 | 125862 | 46244753 |
Ear infection | 11.50 | 9.73 | 219 | 315228 | 22794 | 46347821 |
Angiocentric lymphoma | 11.49 | 9.73 | 15 | 315432 | 454 | 46370161 |
Abdominal distension | 11.46 | 9.73 | 393 | 315054 | 72958 | 46297657 |
Human anti-human antibody test | 11.46 | 9.73 | 13 | 315434 | 339 | 46370276 |
Nervousness | 11.44 | 9.73 | 130 | 315317 | 28345 | 46342270 |
Dry eye | 11.43 | 9.73 | 277 | 315170 | 30045 | 46340570 |
Stress cardiomyopathy | 11.42 | 9.73 | 22 | 315425 | 7762 | 46362853 |
Red blood cell sedimentation rate | 11.42 | 9.73 | 32 | 315415 | 1741 | 46368874 |
Vertigo | 11.42 | 9.73 | 266 | 315181 | 51782 | 46318833 |
Congenital oral malformation | 11.41 | 9.73 | 10 | 315437 | 189 | 46370426 |
Hallucination, auditory | 11.39 | 9.73 | 36 | 315411 | 10720 | 46359895 |
Ventricular hypoplasia | 11.36 | 9.73 | 9 | 315438 | 147 | 46370468 |
Frequent bowel movements | 11.35 | 9.73 | 133 | 315314 | 12499 | 46358116 |
Uterine contractions during pregnancy | 11.35 | 9.73 | 16 | 315431 | 522 | 46370093 |
Viral infection | 11.34 | 9.73 | 276 | 315171 | 29959 | 46340656 |
Device breakage | 11.31 | 9.73 | 31 | 315416 | 9661 | 46360954 |
Vacuum extractor delivery | 11.31 | 9.73 | 9 | 315438 | 148 | 46370467 |
Erysipelas | 11.30 | 9.73 | 83 | 315364 | 6855 | 46363760 |
Delivery | 11.23 | 9.73 | 18 | 315429 | 659 | 46369956 |
Loss of proprioception | 11.16 | 9.73 | 13 | 315434 | 349 | 46370266 |
Sinus tachycardia | 11.16 | 9.73 | 93 | 315354 | 21556 | 46349059 |
Hyperprolactinaemia | 11.15 | 9.73 | 3 | 315444 | 2929 | 46367686 |
Renal mass | 11.14 | 9.73 | 32 | 315415 | 1766 | 46368849 |
Lymphatic fistula | 11.14 | 9.73 | 21 | 315426 | 877 | 46369738 |
Polychondritis | 11.13 | 9.73 | 14 | 315433 | 408 | 46370207 |
Crystal nephropathy | 11.13 | 9.73 | 20 | 315427 | 805 | 46369810 |
Pelvi-ureteric obstruction | 11.12 | 9.73 | 8 | 315439 | 112 | 46370503 |
Abortion | 11.11 | 9.73 | 37 | 315410 | 2213 | 46368402 |
Pulmonary valve stenosis congenital | 11.06 | 9.73 | 9 | 315438 | 153 | 46370462 |
Pleural effusion | 11.06 | 9.73 | 453 | 314994 | 82499 | 46288116 |
Inflammatory marker increased | 11.01 | 9.73 | 69 | 315378 | 5406 | 46365209 |
Anger | 10.98 | 9.73 | 42 | 315405 | 11810 | 46358805 |
Vascular device infection | 10.97 | 9.73 | 5 | 315442 | 3512 | 46367103 |
Femoral hernia incarcerated | 10.96 | 9.73 | 21 | 315426 | 888 | 46369727 |
Nail injury | 10.95 | 9.73 | 14 | 315433 | 415 | 46370200 |
Congenital skin dimples | 10.91 | 9.73 | 9 | 315438 | 156 | 46370459 |
Carpal tunnel syndrome | 10.91 | 9.73 | 159 | 315288 | 15700 | 46354915 |
Congenital megaureter | 10.86 | 9.73 | 7 | 315440 | 81 | 46370534 |
Cleft palate | 10.83 | 9.73 | 21 | 315426 | 896 | 46369719 |
Limb injury | 10.83 | 9.73 | 186 | 315261 | 18988 | 46351627 |
Laryngospasm | 10.81 | 9.73 | 3 | 315444 | 2870 | 46367745 |
Muscle rigidity | 10.79 | 9.73 | 33 | 315414 | 9928 | 46360687 |
Prothrombin consumption time prolonged | 10.76 | 9.73 | 6 | 315441 | 52 | 46370563 |
Conjunctivitis | 10.75 | 9.73 | 155 | 315292 | 15269 | 46355346 |
Stevens-Johnson syndrome | 10.73 | 9.73 | 103 | 315344 | 23194 | 46347421 |
Headache | 10.70 | 9.73 | 2974 | 312473 | 475378 | 45895237 |
Axonal neuropathy | 10.70 | 9.73 | 22 | 315425 | 980 | 46369635 |
Coronary arterial stent insertion | 10.70 | 9.73 | 3 | 315444 | 2850 | 46367765 |
Amniotic fluid volume decreased | 10.67 | 9.73 | 14 | 315433 | 426 | 46370189 |
Endodontic procedure | 10.66 | 9.73 | 39 | 315408 | 2446 | 46368169 |
Creatinine renal clearance decreased | 10.65 | 9.73 | 19 | 315428 | 6901 | 46363714 |
Somnambulism | 10.61 | 9.73 | 11 | 315436 | 5026 | 46365589 |
Pelvic fracture | 10.59 | 9.73 | 122 | 315325 | 11417 | 46359198 |
Abortion induced | 10.58 | 9.73 | 111 | 315336 | 10149 | 46360466 |
Acute respiratory failure | 10.57 | 9.73 | 136 | 315311 | 29002 | 46341613 |
Respiration abnormal | 10.55 | 9.73 | 9 | 315438 | 4512 | 46366103 |
Pleurisy | 10.52 | 9.73 | 89 | 315358 | 7673 | 46362942 |
Renal aplasia | 10.51 | 9.73 | 10 | 315437 | 211 | 46370404 |
Miosis | 10.50 | 9.73 | 18 | 315429 | 6639 | 46363976 |
Syndactyly | 10.49 | 9.73 | 12 | 315435 | 316 | 46370299 |
Acute myeloid leukaemia | 10.47 | 9.73 | 63 | 315384 | 15715 | 46354900 |
Pyrexia | 10.46 | 9.73 | 2139 | 313308 | 346663 | 46023952 |
Cartilage injury | 10.46 | 9.73 | 29 | 315418 | 1568 | 46369047 |
Mucosal toxicity | 10.46 | 9.73 | 12 | 315435 | 317 | 46370298 |
Gastrointestinal haemorrhage | 10.43 | 9.73 | 422 | 315025 | 76951 | 46293664 |
Inflammatory pain | 10.38 | 9.73 | 17 | 315430 | 634 | 46369981 |
Catheter management | 10.37 | 9.73 | 3 | 315444 | 2792 | 46367823 |
Hyperkalaemia | 10.34 | 9.73 | 262 | 315185 | 50447 | 46320168 |
Intestinal stenosis | 10.34 | 9.73 | 39 | 315408 | 2482 | 46368133 |
Carcinoma in situ of skin | 10.32 | 9.73 | 10 | 315437 | 216 | 46370399 |
Pustular psoriasis | 10.29 | 9.73 | 54 | 315393 | 3963 | 46366652 |
Ulcer | 10.29 | 9.73 | 170 | 315277 | 17222 | 46353393 |
Rheumatoid lung | 10.29 | 9.73 | 30 | 315417 | 1670 | 46368945 |
Vascular rupture | 10.26 | 9.73 | 25 | 315422 | 1249 | 46369366 |
Foetal hypokinesia | 10.23 | 9.73 | 14 | 315433 | 444 | 46370171 |
Tachypnoea | 10.22 | 9.73 | 56 | 315391 | 14295 | 46356320 |
Atrial fibrillation | 10.20 | 9.73 | 584 | 314863 | 103006 | 46267609 |
Potentiating drug interaction | 10.19 | 9.73 | 7 | 315440 | 3916 | 46366699 |
Foetal heart rate deceleration abnormality | 10.18 | 9.73 | 14 | 315433 | 446 | 46370169 |
Anal prolapse | 10.18 | 9.73 | 8 | 315439 | 129 | 46370486 |
Mass | 10.17 | 9.73 | 122 | 315325 | 11531 | 46359084 |
Limb malformation | 10.16 | 9.73 | 14 | 315433 | 447 | 46370168 |
Delusion | 10.14 | 9.73 | 40 | 315407 | 11148 | 46359467 |
General physical health deterioration | 10.11 | 9.73 | 660 | 314787 | 115109 | 46255506 |
Product physical issue | 10.11 | 9.73 | 11 | 315436 | 4916 | 46365699 |
Decreased insulin requirement | 10.08 | 9.73 | 8 | 315439 | 131 | 46370484 |
Drug screen positive | 10.03 | 9.73 | 7 | 315440 | 3884 | 46366731 |
Haematocrit decreased | 10.02 | 9.73 | 309 | 315138 | 34748 | 46335867 |
Off label use | 10.02 | 9.73 | 2344 | 313103 | 377497 | 45993118 |
Rheumatoid factor increased | 9.96 | 9.73 | 26 | 315421 | 1356 | 46369259 |
Congenital oesophageal anomaly | 9.95 | 9.73 | 3 | 315444 | 3 | 46370612 |
Congenital neurological disorder | 9.95 | 9.73 | 3 | 315444 | 3 | 46370612 |
Cervix haematoma uterine | 9.95 | 9.73 | 3 | 315444 | 3 | 46370612 |
Gross motor delay | 9.92 | 9.73 | 7 | 315440 | 95 | 46370520 |
Crohn's disease | 9.91 | 9.73 | 79 | 315368 | 6692 | 46363923 |
Myofascial pain syndrome | 9.86 | 9.73 | 32 | 315415 | 1889 | 46368726 |
Selective eating disorder | 9.81 | 9.73 | 30 | 315417 | 1715 | 46368900 |
Teratoma benign | 9.80 | 9.73 | 6 | 315441 | 63 | 46370552 |
Lip swelling | 9.79 | 9.73 | 117 | 315330 | 25278 | 46345337 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Foetal exposure during pregnancy | 780.87 | 9.71 | 926 | 143699 | 35945 | 29771908 |
Rheumatoid arthritis | 415.10 | 9.71 | 727 | 143898 | 40470 | 29767383 |
Drug abuse | 314.08 | 9.71 | 21 | 144604 | 82051 | 29725802 |
Completed suicide | 252.21 | 9.71 | 83 | 144542 | 99409 | 29708444 |
Toxicity to various agents | 250.74 | 9.71 | 292 | 144333 | 176891 | 29630962 |
Atrial septal defect | 232.27 | 9.71 | 219 | 144406 | 6482 | 29801371 |
Small for dates baby | 222.18 | 9.71 | 157 | 144468 | 3051 | 29804802 |
Arthralgia | 170.60 | 9.71 | 1181 | 143444 | 134610 | 29673243 |
Hypospadias | 167.00 | 9.71 | 123 | 144502 | 2556 | 29805297 |
Premature baby | 164.65 | 9.71 | 292 | 144333 | 16399 | 29791454 |
Ventricular septal defect | 139.19 | 9.71 | 124 | 144501 | 3405 | 29804448 |
Psoriatic arthropathy | 113.00 | 9.71 | 241 | 144384 | 15520 | 29792333 |
Maternal exposure during pregnancy | 110.85 | 9.71 | 114 | 144511 | 3757 | 29804096 |
Dysmorphism | 108.91 | 9.71 | 85 | 144540 | 1932 | 29805921 |
Sickle cell anaemia with crisis | 103.98 | 9.71 | 89 | 144536 | 2313 | 29805540 |
Neonatal respiratory distress syndrome | 98.70 | 9.71 | 109 | 144516 | 3903 | 29803950 |
Death | 95.36 | 9.71 | 1187 | 143438 | 356096 | 29451757 |
Cryptorchism | 89.10 | 9.71 | 70 | 144555 | 1607 | 29806246 |
Respiratory disorder neonatal | 88.96 | 9.71 | 61 | 144564 | 1127 | 29806726 |
Pancytopenia | 88.04 | 9.71 | 707 | 143918 | 84345 | 29723508 |
Agitation neonatal | 87.26 | 9.71 | 57 | 144568 | 968 | 29806885 |
Joint swelling | 81.34 | 9.71 | 444 | 144181 | 46502 | 29761351 |
Congenital umbilical hernia | 80.61 | 9.71 | 39 | 144586 | 356 | 29807497 |
Drug interaction | 77.46 | 9.71 | 605 | 144020 | 198963 | 29608890 |
Maternal drugs affecting foetus | 76.91 | 9.71 | 99 | 144526 | 4174 | 29803679 |
Exposure during pregnancy | 76.30 | 9.71 | 150 | 144475 | 9111 | 29798742 |
Intentional overdose | 73.00 | 9.71 | 56 | 144569 | 41425 | 29766428 |
Low birth weight baby | 71.46 | 9.71 | 115 | 144510 | 5961 | 29801892 |
Hypoglycaemia neonatal | 71.28 | 9.71 | 60 | 144565 | 1523 | 29806330 |
Tenosynovitis | 70.55 | 9.71 | 86 | 144539 | 3429 | 29804424 |
Haemangioma congenital | 67.35 | 9.71 | 38 | 144587 | 488 | 29807365 |
Enthesopathy | 64.76 | 9.71 | 75 | 144550 | 2831 | 29805022 |
Overdose | 61.66 | 9.71 | 205 | 144420 | 84132 | 29723721 |
Suicide attempt | 61.49 | 9.71 | 52 | 144573 | 36645 | 29771208 |
Foetal anticonvulsant syndrome | 60.95 | 9.71 | 41 | 144584 | 733 | 29807120 |
Hypotonia neonatal | 59.13 | 9.71 | 45 | 144580 | 984 | 29806869 |
Syndactyly | 57.89 | 9.71 | 39 | 144586 | 699 | 29807154 |
Nasopharyngitis | 56.47 | 9.71 | 481 | 144144 | 58368 | 29749485 |
Talipes | 54.73 | 9.71 | 53 | 144572 | 1622 | 29806231 |
Bradycardia neonatal | 54.73 | 9.71 | 41 | 144584 | 875 | 29806978 |
Speech disorder developmental | 53.73 | 9.71 | 45 | 144580 | 1134 | 29806719 |
Renal aplasia | 53.59 | 9.71 | 36 | 144589 | 642 | 29807211 |
Musculoskeletal stiffness | 53.42 | 9.71 | 326 | 144299 | 35555 | 29772298 |
Hypertonia neonatal | 51.27 | 9.71 | 28 | 144597 | 336 | 29807517 |
Intentional product misuse | 51.22 | 9.71 | 55 | 144570 | 34612 | 29773241 |
Hyperbilirubinaemia neonatal | 50.65 | 9.71 | 35 | 144590 | 655 | 29807198 |
Patent ductus arteriosus | 50.24 | 9.71 | 69 | 144556 | 3100 | 29804753 |
Blood pressure fluctuation | 50.11 | 9.71 | 192 | 144433 | 17311 | 29790542 |
Drug withdrawal syndrome neonatal | 48.64 | 9.71 | 68 | 144557 | 3107 | 29804746 |
Synovitis | 47.86 | 9.71 | 129 | 144496 | 9654 | 29798199 |
Selective eating disorder | 47.15 | 9.71 | 49 | 144576 | 1635 | 29806218 |
Hepatic function abnormal | 46.44 | 9.71 | 82 | 144543 | 41863 | 29765990 |
Large for dates baby | 45.54 | 9.71 | 36 | 144589 | 834 | 29807019 |
Psoriasis | 44.84 | 9.71 | 355 | 144270 | 42151 | 29765702 |
Maternal exposure during breast feeding | 44.82 | 9.71 | 47 | 144578 | 1585 | 29806268 |
Drug resistance | 44.05 | 9.71 | 21 | 144604 | 20112 | 29787741 |
Drug reaction with eosinophilia and systemic symptoms | 43.43 | 9.71 | 44 | 144581 | 28444 | 29779409 |
Developmental delay | 42.35 | 9.71 | 52 | 144573 | 2089 | 29805764 |
Tongue disorder | 41.82 | 9.71 | 75 | 144550 | 4247 | 29803606 |
Basal cell carcinoma | 40.97 | 9.71 | 170 | 144455 | 15898 | 29791955 |
Exposure via breast milk | 40.92 | 9.71 | 44 | 144581 | 1528 | 29806325 |
Drug withdrawal syndrome | 39.89 | 9.71 | 23 | 144602 | 19786 | 29788067 |
Cardiac arrest | 39.02 | 9.71 | 275 | 144350 | 92575 | 29715278 |
Pulmonary fibrosis | 38.87 | 9.71 | 166 | 144459 | 15724 | 29792129 |
Drug dependence | 38.42 | 9.71 | 28 | 144597 | 21267 | 29786586 |
Rhabdomyolysis | 38.39 | 9.71 | 167 | 144458 | 63413 | 29744440 |
Coma | 37.99 | 9.71 | 87 | 144538 | 40362 | 29767491 |
Caesarean section | 37.66 | 9.71 | 49 | 144576 | 2088 | 29805765 |
Serotonin syndrome | 37.14 | 9.71 | 20 | 144605 | 17871 | 29789982 |
Foetal growth restriction | 37.00 | 9.71 | 64 | 144561 | 3521 | 29804332 |
Rheumatoid nodule | 36.63 | 9.71 | 43 | 144582 | 1647 | 29806206 |
Palmar-plantar erythrodysaesthesia syndrome | 36.60 | 9.71 | 13 | 144612 | 14857 | 29792996 |
Spina bifida | 36.56 | 9.71 | 22 | 144603 | 321 | 29807532 |
Febrile neutropenia | 36.11 | 9.71 | 335 | 144290 | 106358 | 29701495 |
Autism spectrum disorder | 36.10 | 9.71 | 38 | 144587 | 1287 | 29806566 |
Foot deformity | 35.01 | 9.71 | 61 | 144564 | 3376 | 29804477 |
C-reactive protein abnormal | 34.99 | 9.71 | 81 | 144544 | 5512 | 29802341 |
Respiratory arrest | 34.41 | 9.71 | 55 | 144570 | 29203 | 29778650 |
Agitation | 33.27 | 9.71 | 141 | 144484 | 53932 | 29753921 |
Infusion related reaction | 33.01 | 9.71 | 320 | 144305 | 40244 | 29767609 |
Plagiocephaly | 31.97 | 9.71 | 20 | 144605 | 314 | 29807539 |
Suicidal ideation | 31.30 | 9.71 | 81 | 144544 | 36033 | 29771820 |
Haemoglobin decreased | 31.19 | 9.71 | 746 | 143879 | 113352 | 29694501 |
Congenital hydronephrosis | 31.19 | 9.71 | 26 | 144599 | 651 | 29807202 |
Birth mark | 30.29 | 9.71 | 17 | 144608 | 216 | 29807637 |
Drug intolerance | 30.12 | 9.71 | 343 | 144282 | 44948 | 29762905 |
General physical health deterioration | 29.96 | 9.71 | 662 | 143963 | 99282 | 29708571 |
Poisoning | 29.68 | 9.71 | 9 | 144616 | 11373 | 29796480 |
Arthritis | 29.22 | 9.71 | 210 | 144415 | 24191 | 29783662 |
Osteoarthritis | 28.76 | 9.71 | 169 | 144456 | 18180 | 29789673 |
Renal failure | 28.64 | 9.71 | 444 | 144181 | 128522 | 29679331 |
Kidney duplex | 28.37 | 9.71 | 19 | 144606 | 337 | 29807516 |
Congenital tricuspid valve incompetence | 28.37 | 9.71 | 14 | 144611 | 134 | 29807719 |
Intellectual disability | 28.30 | 9.71 | 27 | 144598 | 811 | 29807042 |
Bradycardia | 28.05 | 9.71 | 193 | 144432 | 65333 | 29742520 |
Medical device implantation | 27.71 | 9.71 | 22 | 144603 | 513 | 29807340 |
Angioedema | 27.64 | 9.71 | 80 | 144545 | 34304 | 29773549 |
Pain | 27.51 | 9.71 | 1056 | 143569 | 171585 | 29636268 |
Blood creatine phosphokinase increased | 27.18 | 9.71 | 114 | 144511 | 43734 | 29764119 |
Constipation | 27.04 | 9.71 | 383 | 144242 | 112523 | 29695330 |
Delirium | 26.85 | 9.71 | 103 | 144522 | 40528 | 29767325 |
Altered state of consciousness | 26.84 | 9.71 | 34 | 144591 | 19885 | 29787968 |
Folate deficiency | 25.84 | 9.71 | 28 | 144597 | 981 | 29806872 |
Arthropathy | 25.76 | 9.71 | 180 | 144445 | 20547 | 29787306 |
Abnormal palmar/plantar creases | 25.65 | 9.71 | 15 | 144610 | 207 | 29807646 |
Neonatal seizure | 25.42 | 9.71 | 20 | 144605 | 460 | 29807393 |
Lower respiratory tract infection | 25.42 | 9.71 | 218 | 144407 | 26496 | 29781357 |
Hyperglycaemia | 25.40 | 9.71 | 86 | 144539 | 35114 | 29772739 |
Low set ears | 25.34 | 9.71 | 19 | 144606 | 406 | 29807447 |
Foetal heart rate deceleration abnormality | 25.22 | 9.71 | 19 | 144606 | 409 | 29807444 |
Pathogen resistance | 25.14 | 9.71 | 5 | 144620 | 8405 | 29799448 |
Electrocardiogram QT prolonged | 24.88 | 9.71 | 89 | 144536 | 35746 | 29772107 |
Alanine aminotransferase abnormal | 24.77 | 9.71 | 45 | 144580 | 2574 | 29805279 |
Hypermobility syndrome | 24.23 | 9.71 | 15 | 144610 | 231 | 29807622 |
Product use in unapproved indication | 24.23 | 9.71 | 233 | 144392 | 73460 | 29734393 |
Blood pressure systolic abnormal | 24.17 | 9.71 | 33 | 144592 | 1474 | 29806379 |
Skin cancer | 24.17 | 9.71 | 89 | 144536 | 7872 | 29799981 |
Motor developmental delay | 24.16 | 9.71 | 17 | 144608 | 328 | 29807525 |
Dermatitis psoriasiform | 24.07 | 9.71 | 29 | 144596 | 1142 | 29806711 |
Pyelocaliectasis | 23.93 | 9.71 | 27 | 144598 | 990 | 29806863 |
Congenital hand malformation | 23.79 | 9.71 | 19 | 144606 | 447 | 29807406 |
Single umbilical artery | 23.68 | 9.71 | 15 | 144610 | 241 | 29807612 |
Blood pressure systolic increased | 23.57 | 9.71 | 139 | 144486 | 14971 | 29792882 |
Juvenile idiopathic arthritis | 23.38 | 9.71 | 27 | 144598 | 1016 | 29806837 |
Infantile apnoea | 23.34 | 9.71 | 25 | 144600 | 864 | 29806989 |
Loss of personal independence in daily activities | 23.33 | 9.71 | 181 | 144444 | 21354 | 29786499 |
Disease progression | 23.21 | 9.71 | 260 | 144365 | 79614 | 29728239 |
Serum ferritin increased | 22.98 | 9.71 | 68 | 144557 | 5369 | 29802484 |
Knee arthroplasty | 22.46 | 9.71 | 69 | 144556 | 5561 | 29802292 |
Temperature regulation disorder | 22.22 | 9.71 | 19 | 144606 | 493 | 29807360 |
Weight decrease neonatal | 22.20 | 9.71 | 16 | 144609 | 321 | 29807532 |
Congenital myopia | 22.12 | 9.71 | 7 | 144618 | 16 | 29807837 |
Anal fistula | 22.00 | 9.71 | 55 | 144570 | 3931 | 29803922 |
Infective pulmonary exacerbation of cystic fibrosis | 21.95 | 9.71 | 7 | 144618 | 8565 | 29799288 |
Congenital knee deformity | 21.79 | 9.71 | 9 | 144616 | 54 | 29807799 |
Congenital skin dimples | 21.76 | 9.71 | 12 | 144613 | 147 | 29807706 |
Shock | 21.60 | 9.71 | 49 | 144576 | 22810 | 29785043 |
Prostate cancer | 21.49 | 9.71 | 193 | 144432 | 23764 | 29784089 |
Floppy infant | 21.48 | 9.71 | 10 | 144615 | 83 | 29807770 |
Substance abuse | 21.44 | 9.71 | 4 | 144621 | 7036 | 29800817 |
Developmental coordination disorder | 21.42 | 9.71 | 8 | 144617 | 35 | 29807818 |
Product quality issue | 21.42 | 9.71 | 36 | 144589 | 18738 | 29789115 |
Musculoskeletal pain | 21.33 | 9.71 | 236 | 144389 | 30704 | 29777149 |
Knee deformity | 21.29 | 9.71 | 16 | 144609 | 343 | 29807510 |
Polydactyly | 21.27 | 9.71 | 28 | 144597 | 1207 | 29806646 |
Psychotic disorder | 21.25 | 9.71 | 45 | 144580 | 21470 | 29786383 |
Cleft lip and palate | 21.24 | 9.71 | 15 | 144610 | 291 | 29807562 |
Vitamin D deficiency | 21.22 | 9.71 | 64 | 144561 | 5106 | 29802747 |
Congenital astigmatism | 21.01 | 9.71 | 7 | 144618 | 20 | 29807833 |
Sedation | 20.98 | 9.71 | 29 | 144596 | 16344 | 29791509 |
Arthritis bacterial | 20.97 | 9.71 | 58 | 144567 | 4406 | 29803447 |
Urticaria | 20.89 | 9.71 | 166 | 144459 | 54440 | 29753413 |
Neuroleptic malignant syndrome | 20.74 | 9.71 | 29 | 144596 | 16266 | 29791587 |
Joint effusion | 20.70 | 9.71 | 51 | 144574 | 3612 | 29804241 |
Somnolence | 20.50 | 9.71 | 336 | 144289 | 96427 | 29711426 |
Otitis media | 20.40 | 9.71 | 41 | 144584 | 2530 | 29805323 |
Immunosuppression | 20.25 | 9.71 | 63 | 144562 | 5112 | 29802741 |
Pulmonary artery stenosis congenital | 20.18 | 9.71 | 18 | 144607 | 495 | 29807358 |
Microcephaly | 20.13 | 9.71 | 20 | 144605 | 632 | 29807221 |
Hand deformity | 20.07 | 9.71 | 34 | 144591 | 1839 | 29806014 |
Joint range of motion decreased | 20.03 | 9.71 | 68 | 144557 | 5777 | 29802076 |
Foetal disorder | 19.97 | 9.71 | 20 | 144605 | 638 | 29807215 |
Joint laxity | 19.30 | 9.71 | 9 | 144616 | 75 | 29807778 |
Post procedural infection | 19.15 | 9.71 | 57 | 144568 | 4515 | 29803338 |
Sopor | 19.12 | 9.71 | 15 | 144610 | 10976 | 29796877 |
Congenital bladder anomaly | 18.96 | 9.71 | 14 | 144611 | 292 | 29807561 |
Cardio-respiratory arrest | 18.91 | 9.71 | 181 | 144444 | 57125 | 29750728 |
Pectus excavatum | 18.90 | 9.71 | 9 | 144616 | 79 | 29807774 |
Ectopic kidney | 18.71 | 9.71 | 8 | 144617 | 53 | 29807800 |
Blood pressure increased | 18.65 | 9.71 | 467 | 144158 | 71461 | 29736392 |
Maternal exposure before pregnancy | 18.63 | 9.71 | 15 | 144610 | 357 | 29807496 |
Multiple congenital abnormalities | 18.28 | 9.71 | 17 | 144608 | 494 | 29807359 |
Tendonitis | 18.17 | 9.71 | 82 | 144543 | 7954 | 29799899 |
Limb malformation | 17.98 | 9.71 | 14 | 144611 | 317 | 29807536 |
Tuberculosis | 17.95 | 9.71 | 82 | 144543 | 7995 | 29799858 |
Lacrimal disorder | 17.94 | 9.71 | 14 | 144611 | 318 | 29807535 |
Hydrocele | 17.93 | 9.71 | 34 | 144591 | 2010 | 29805843 |
Cleft palate | 17.58 | 9.71 | 18 | 144607 | 590 | 29807263 |
Jaundice neonatal | 17.56 | 9.71 | 24 | 144601 | 1073 | 29806780 |
Language disorder | 17.41 | 9.71 | 26 | 144599 | 1262 | 29806591 |
Tonsil cancer | 17.41 | 9.71 | 20 | 144605 | 748 | 29807105 |
Respiratory failure | 17.41 | 9.71 | 362 | 144263 | 100280 | 29707573 |
Ankyloglossia congenital | 17.37 | 9.71 | 13 | 144612 | 277 | 29807576 |
Acute hepatic failure | 17.20 | 9.71 | 19 | 144606 | 11808 | 29796045 |
Body temperature decreased | 17.17 | 9.71 | 92 | 144533 | 9563 | 29798290 |
Hypoxia | 17.16 | 9.71 | 148 | 144477 | 47706 | 29760147 |
Haematocrit decreased | 17.15 | 9.71 | 225 | 144400 | 30474 | 29777379 |
Depressed level of consciousness | 17.14 | 9.71 | 111 | 144514 | 38111 | 29769742 |
Pain in extremity | 17.00 | 9.71 | 672 | 143953 | 109549 | 29698304 |
Pulmonary valve stenosis congenital | 16.98 | 9.71 | 10 | 144615 | 140 | 29807713 |
Transposition of the great vessels | 16.89 | 9.71 | 16 | 144609 | 476 | 29807377 |
Hypoglycaemia | 16.83 | 9.71 | 161 | 144464 | 50820 | 29757033 |
Poor venous access | 16.72 | 9.71 | 37 | 144588 | 2443 | 29805410 |
Kinematic imbalances due to suboccipital strain | 16.49 | 9.71 | 6 | 144619 | 24 | 29807829 |
Microphthalmos | 16.48 | 9.71 | 11 | 144614 | 194 | 29807659 |
Dyspraxia | 16.43 | 9.71 | 12 | 144613 | 246 | 29807607 |
Nasal disorder | 16.35 | 9.71 | 24 | 144601 | 1147 | 29806706 |
Hepatic failure | 16.23 | 9.71 | 97 | 144528 | 33946 | 29773907 |
Post transplant lymphoproliferative disorder | 16.19 | 9.71 | 3 | 144622 | 5303 | 29802550 |
Wound | 16.18 | 9.71 | 109 | 144516 | 12293 | 29795560 |
Hallucination | 16.16 | 9.71 | 155 | 144470 | 48904 | 29758949 |
Off label use | 16.10 | 9.71 | 1013 | 143612 | 248277 | 29559576 |
Mean cell volume increased | 15.97 | 9.71 | 33 | 144592 | 2077 | 29805776 |
Acute kidney injury | 15.97 | 9.71 | 1123 | 143502 | 272719 | 29535134 |
Congenital cerebral cyst | 15.93 | 9.71 | 5 | 144620 | 11 | 29807842 |
Neck mass | 15.85 | 9.71 | 26 | 144599 | 1369 | 29806484 |
Hepatic cyst | 15.82 | 9.71 | 36 | 144589 | 2422 | 29805431 |
Cleft lip | 15.78 | 9.71 | 13 | 144612 | 320 | 29807533 |
Renal impairment | 15.70 | 9.71 | 299 | 144326 | 83885 | 29723968 |
Malignant neoplasm progression | 15.64 | 9.71 | 250 | 144375 | 72037 | 29735816 |
Accessory spleen | 15.50 | 9.71 | 10 | 144615 | 166 | 29807687 |
Learning disorder | 15.44 | 9.71 | 15 | 144610 | 461 | 29807392 |
Coarctation of the aorta | 15.41 | 9.71 | 15 | 144610 | 462 | 29807391 |
Intentional self-injury | 15.39 | 9.71 | 26 | 144599 | 13506 | 29794347 |
Base excess decreased | 15.38 | 9.71 | 11 | 144614 | 218 | 29807635 |
Peripheral swelling | 15.38 | 9.71 | 395 | 144230 | 60679 | 29747174 |
Lung neoplasm malignant | 15.20 | 9.71 | 125 | 144500 | 15007 | 29792846 |
Epispadias | 15.10 | 9.71 | 10 | 144615 | 174 | 29807679 |
Poikiloderma | 15.05 | 9.71 | 10 | 144615 | 175 | 29807678 |
Arthrodesis | 14.99 | 9.71 | 14 | 144611 | 409 | 29807444 |
Injection site pain | 14.84 | 9.71 | 217 | 144408 | 30093 | 29777760 |
Maternal exposure timing unspecified | 14.77 | 9.71 | 13 | 144612 | 351 | 29807502 |
Wrong technique in product usage process | 14.73 | 9.71 | 89 | 144536 | 31066 | 29776787 |
Umbilical hernia | 14.73 | 9.71 | 45 | 144580 | 3616 | 29804237 |
Diverticular perforation | 14.65 | 9.71 | 41 | 144584 | 3136 | 29804717 |
Pulmonary valve stenosis | 14.62 | 9.71 | 13 | 144612 | 356 | 29807497 |
Kyphosis congenital | 14.60 | 9.71 | 4 | 144621 | 4 | 29807849 |
Incorrect route of product administration | 14.54 | 9.71 | 20 | 144605 | 11295 | 29796558 |
Joint stiffness | 14.53 | 9.71 | 86 | 144539 | 9275 | 29798578 |
Bronchial carcinoma | 14.50 | 9.71 | 20 | 144605 | 902 | 29806951 |
Pseudolymphoma | 14.44 | 9.71 | 15 | 144610 | 500 | 29807353 |
Cytomegalovirus infection | 14.39 | 9.71 | 62 | 144563 | 23612 | 29784241 |
Congenital melanocytic naevus | 14.36 | 9.71 | 5 | 144620 | 17 | 29807836 |
Anal atresia | 14.28 | 9.71 | 12 | 144613 | 304 | 29807549 |
Grip strength decreased | 14.23 | 9.71 | 32 | 144593 | 2136 | 29805717 |
Therapeutic product effect decreased | 14.17 | 9.71 | 208 | 144417 | 28868 | 29778985 |
Congenital anomaly | 14.17 | 9.71 | 24 | 144601 | 1298 | 29806555 |
Malignant melanoma | 14.13 | 9.71 | 72 | 144553 | 7339 | 29800514 |
Blood pressure diastolic increased | 14.13 | 9.71 | 37 | 144588 | 2721 | 29805132 |
Dysgraphia | 14.09 | 9.71 | 26 | 144599 | 1505 | 29806348 |
Prominent epicanthal folds | 14.08 | 9.71 | 9 | 144616 | 147 | 29807706 |
Septic arthritis staphylococcal | 14.07 | 9.71 | 14 | 144611 | 443 | 29807410 |
Drug-induced liver injury | 14.01 | 9.71 | 54 | 144571 | 21220 | 29786633 |
Plasma cell myeloma | 14.00 | 9.71 | 178 | 144447 | 53284 | 29754569 |
Red blood cell sedimentation rate increased | 14.00 | 9.71 | 71 | 144554 | 7224 | 29800629 |
Infection | 13.97 | 9.71 | 484 | 144141 | 77590 | 29730263 |
Intraventricular haemorrhage neonatal | 13.90 | 9.71 | 10 | 144615 | 200 | 29807653 |
Unresponsive to stimuli | 13.83 | 9.71 | 73 | 144552 | 26346 | 29781507 |
Congenital megaureter | 13.77 | 9.71 | 8 | 144617 | 109 | 29807744 |
Hydrops foetalis | 13.76 | 9.71 | 11 | 144614 | 259 | 29807594 |
Emphysema | 13.72 | 9.71 | 85 | 144540 | 9317 | 29798536 |
Fine motor skill dysfunction | 13.69 | 9.71 | 22 | 144603 | 1139 | 29806714 |
Anxiety | 13.62 | 9.71 | 330 | 144295 | 89541 | 29718312 |
Peripheral artery thrombosis | 13.61 | 9.71 | 32 | 144593 | 2200 | 29805653 |
Oesophageal adenocarcinoma | 13.59 | 9.71 | 19 | 144606 | 868 | 29806985 |
Toxic epidermal necrolysis | 13.51 | 9.71 | 43 | 144582 | 17897 | 29789956 |
Congenital central nervous system anomaly | 13.50 | 9.71 | 13 | 144612 | 395 | 29807458 |
Cerebral haemorrhage neonatal | 13.41 | 9.71 | 11 | 144614 | 269 | 29807584 |
Vitamin B12 deficiency | 13.40 | 9.71 | 35 | 144590 | 2570 | 29805283 |
Foetal distress syndrome | 13.39 | 9.71 | 20 | 144605 | 971 | 29806882 |
Finger deformity | 13.38 | 9.71 | 20 | 144605 | 972 | 29806881 |
Asthma | 13.36 | 9.71 | 111 | 144514 | 36063 | 29771790 |
Pulmonary artery stenosis | 13.33 | 9.71 | 9 | 144616 | 162 | 29807691 |
Joint contracture | 13.29 | 9.71 | 28 | 144597 | 1787 | 29806066 |
Neutrophil count decreased | 13.20 | 9.71 | 136 | 144489 | 42318 | 29765535 |
Congenital mitral valve incompetence | 13.11 | 9.71 | 7 | 144618 | 80 | 29807773 |
Hypotension | 13.11 | 9.71 | 814 | 143811 | 199751 | 29608102 |
Haptoglobin decreased | 13.10 | 9.71 | 15 | 144610 | 559 | 29807294 |
Mouth ulceration | 13.10 | 9.71 | 92 | 144533 | 10517 | 29797336 |
Injection site bruising | 13.10 | 9.71 | 70 | 144555 | 7268 | 29800585 |
Ventricular fibrillation | 13.08 | 9.71 | 34 | 144591 | 15104 | 29792749 |
Immunodeficiency | 13.03 | 9.71 | 48 | 144577 | 4246 | 29803607 |
Umbilical granuloma | 13.01 | 9.71 | 3 | 144622 | 0 | 29807853 |
Ultrasound antenatal screen | 13.01 | 9.71 | 3 | 144622 | 0 | 29807853 |
Ophthalmia neonatorum | 13.01 | 9.71 | 3 | 144622 | 0 | 29807853 |
Diabetic ketoacidosis | 12.99 | 9.71 | 37 | 144588 | 15949 | 29791904 |
Oxygen consumption decreased | 12.95 | 9.71 | 9 | 144616 | 170 | 29807683 |
Ear infection | 12.93 | 9.71 | 70 | 144555 | 7304 | 29800549 |
Vascular insufficiency | 12.89 | 9.71 | 12 | 144613 | 349 | 29807504 |
Venoocclusive liver disease | 12.86 | 9.71 | 8 | 144617 | 6605 | 29801248 |
Aggression | 12.85 | 9.71 | 115 | 144510 | 36792 | 29771061 |
Latent tuberculosis | 12.82 | 9.71 | 19 | 144606 | 916 | 29806937 |
Hernia pain | 12.79 | 9.71 | 10 | 144615 | 228 | 29807625 |
Skull malformation | 12.73 | 9.71 | 12 | 144613 | 355 | 29807498 |
Pyrexia | 12.70 | 9.71 | 1237 | 143388 | 293252 | 29514601 |
Bronchiolitis | 12.70 | 9.71 | 33 | 144592 | 2415 | 29805438 |
Weight decreased | 12.60 | 9.71 | 868 | 143757 | 150053 | 29657800 |
Arthritis infective | 12.59 | 9.71 | 35 | 144590 | 2667 | 29805186 |
Erectile dysfunction | 12.54 | 9.71 | 45 | 144580 | 18057 | 29789796 |
Strabismus | 12.46 | 9.71 | 21 | 144604 | 1131 | 29806722 |
Foetal hypokinesia | 12.45 | 9.71 | 12 | 144613 | 365 | 29807488 |
Blood insulin increased | 12.37 | 9.71 | 12 | 144613 | 368 | 29807485 |
Reticulocytosis | 12.35 | 9.71 | 11 | 144614 | 302 | 29807551 |
C-reactive protein decreased | 12.33 | 9.71 | 25 | 144600 | 1553 | 29806300 |
Astigmatism | 12.30 | 9.71 | 17 | 144608 | 768 | 29807085 |
Hypothermia neonatal | 12.27 | 9.71 | 7 | 144618 | 92 | 29807761 |
Haemolysis | 12.25 | 9.71 | 68 | 144557 | 7163 | 29800690 |
Clinodactyly | 12.24 | 9.71 | 8 | 144617 | 136 | 29807717 |
Nightmare | 12.14 | 9.71 | 25 | 144600 | 12051 | 29795802 |
Placental insufficiency | 12.14 | 9.71 | 7 | 144618 | 94 | 29807759 |
Cystitis haemorrhagic | 12.10 | 9.71 | 4 | 144621 | 4783 | 29803070 |
Cholelithiasis | 12.04 | 9.71 | 150 | 144475 | 20075 | 29787778 |
Oropharyngeal pain | 12.04 | 9.71 | 199 | 144426 | 28297 | 29779556 |
Sexual dysfunction | 12.03 | 9.71 | 7 | 144618 | 5994 | 29801859 |
Lung cancer metastatic | 12.03 | 9.71 | 33 | 144592 | 2495 | 29805358 |
Blood pressure diastolic abnormal | 12.03 | 9.71 | 22 | 144603 | 1265 | 29806588 |
Neonatal respiratory distress | 12.01 | 9.71 | 13 | 144612 | 455 | 29807398 |
Arnold-Chiari malformation | 11.94 | 9.71 | 10 | 144615 | 252 | 29807601 |
Stevens-Johnson syndrome | 11.92 | 9.71 | 44 | 144581 | 17512 | 29790341 |
JC virus CSF test positive | 11.88 | 9.71 | 7 | 144618 | 98 | 29807755 |
Scleroderma renal crisis | 11.88 | 9.71 | 7 | 144618 | 98 | 29807755 |
Oesophageal atresia | 11.87 | 9.71 | 13 | 144612 | 461 | 29807392 |
Skin indentation | 11.87 | 9.71 | 4 | 144621 | 12 | 29807841 |
Palindromic rheumatism | 11.86 | 9.71 | 9 | 144616 | 196 | 29807657 |
Crohn's disease | 11.85 | 9.71 | 47 | 144578 | 4305 | 29803548 |
Peritoneal tuberculosis | 11.75 | 9.71 | 12 | 144613 | 392 | 29807461 |
Hypertrophy | 11.71 | 9.71 | 11 | 144614 | 324 | 29807529 |
Abnormal behaviour | 11.70 | 9.71 | 74 | 144551 | 25549 | 29782304 |
Lower respiratory tract congestion | 11.68 | 9.71 | 19 | 144606 | 994 | 29806859 |
Sinusitis | 11.66 | 9.71 | 226 | 144399 | 33119 | 29774734 |
Premature delivery | 11.64 | 9.71 | 7 | 144618 | 102 | 29807751 |
Laryngomalacia | 11.61 | 9.71 | 10 | 144615 | 262 | 29807591 |
Excessive cerumen production | 11.61 | 9.71 | 10 | 144615 | 262 | 29807591 |
Cellulitis | 11.60 | 9.71 | 302 | 144323 | 46482 | 29761371 |
Gangrene neonatal | 11.51 | 9.71 | 9 | 144616 | 205 | 29807648 |
Developmental hip dysplasia | 11.49 | 9.71 | 10 | 144615 | 266 | 29807587 |
Congenital musculoskeletal anomaly | 11.44 | 9.71 | 9 | 144616 | 207 | 29807646 |
Pleural fibrosis | 11.43 | 9.71 | 23 | 144602 | 1421 | 29806432 |
Poor sucking reflex | 11.42 | 9.71 | 10 | 144615 | 268 | 29807585 |
Abnormal labour affecting foetus | 11.40 | 9.71 | 4 | 144621 | 14 | 29807839 |
Injection site swelling | 11.35 | 9.71 | 77 | 144548 | 8703 | 29799150 |
Scleroedema | 11.34 | 9.71 | 5 | 144620 | 36 | 29807817 |
Congenital aortic valve incompetence | 11.34 | 9.71 | 8 | 144617 | 155 | 29807698 |
Kidney infection | 11.33 | 9.71 | 48 | 144577 | 4530 | 29803323 |
Moaning | 11.31 | 9.71 | 16 | 144609 | 739 | 29807114 |
Neuroendocrine tumour of the lung metastatic | 11.30 | 9.71 | 7 | 144618 | 108 | 29807745 |
Bursitis | 11.28 | 9.71 | 48 | 144577 | 4538 | 29803315 |
Inguinal hernia | 11.27 | 9.71 | 66 | 144559 | 7089 | 29800764 |
Intestinal stenosis | 11.27 | 9.71 | 27 | 144598 | 1878 | 29805975 |
Pneumonia | 11.21 | 9.71 | 1807 | 142818 | 332499 | 29475354 |
Nose deformity | 11.21 | 9.71 | 8 | 144617 | 158 | 29807695 |
Duodenal atresia | 11.19 | 9.71 | 4 | 144621 | 15 | 29807838 |
Prognathism | 11.19 | 9.71 | 4 | 144621 | 15 | 29807838 |
Micropenis | 11.12 | 9.71 | 5 | 144620 | 38 | 29807815 |
Neurotoxicity | 11.09 | 9.71 | 30 | 144595 | 13152 | 29794701 |
Alcohol abuse | 11.09 | 9.71 | 6 | 144619 | 5347 | 29802506 |
Congenital diaphragmatic hernia | 11.08 | 9.71 | 9 | 144616 | 217 | 29807636 |
Delusion | 11.08 | 9.71 | 26 | 144599 | 11963 | 29795890 |
Radiation inflammation | 11.02 | 9.71 | 7 | 144618 | 113 | 29807740 |
Glycosylated haemoglobin increased | 11.01 | 9.71 | 18 | 144607 | 9473 | 29798380 |
No adverse event | 10.97 | 9.71 | 45 | 144580 | 17374 | 29790479 |
Hernia congenital | 10.95 | 9.71 | 3 | 144622 | 3 | 29807850 |
Urinary tract malformation | 10.95 | 9.71 | 3 | 144622 | 3 | 29807850 |
Encephalocele | 10.95 | 9.71 | 3 | 144622 | 3 | 29807850 |
Myalgia | 10.94 | 9.71 | 284 | 144341 | 76383 | 29731470 |
Thinking abnormal | 10.93 | 9.71 | 6 | 144619 | 5305 | 29802548 |
Dermatitis acneiform | 10.90 | 9.71 | 7 | 144618 | 5682 | 29802171 |
Tachycardia | 10.83 | 9.71 | 272 | 144353 | 73467 | 29734386 |
Red blood cell count decreased | 10.82 | 9.71 | 183 | 144442 | 26138 | 29781715 |
Major depression | 10.82 | 9.71 | 3 | 144622 | 4019 | 29803834 |
Strabismus congenital | 10.79 | 9.71 | 5 | 144620 | 41 | 29807812 |
Gastrooesophageal sphincter insufficiency | 10.77 | 9.71 | 6 | 144619 | 75 | 29807778 |
Ear disorder | 10.75 | 9.71 | 17 | 144608 | 868 | 29806985 |
Adenomatous polyposis coli | 10.75 | 9.71 | 8 | 144617 | 169 | 29807684 |
Anti-erythropoietin antibody positive | 10.63 | 9.71 | 17 | 144608 | 876 | 29806977 |
Steatorrhoea | 10.63 | 9.71 | 15 | 144610 | 691 | 29807162 |
Foetal heart rate abnormal | 10.63 | 9.71 | 8 | 144617 | 172 | 29807681 |
Aorticopulmonary septal defect | 10.62 | 9.71 | 4 | 144621 | 18 | 29807835 |
Meconium in amniotic fluid | 10.62 | 9.71 | 4 | 144621 | 18 | 29807835 |
Squamous cell carcinoma of lung | 10.60 | 9.71 | 25 | 144600 | 1722 | 29806131 |
Brain oedema | 10.59 | 9.71 | 28 | 144597 | 12370 | 29795483 |
Skin infection | 10.55 | 9.71 | 58 | 144567 | 6086 | 29801767 |
Lipase increased | 10.49 | 9.71 | 16 | 144609 | 8660 | 29799193 |
Multiple organ dysfunction syndrome | 10.49 | 9.71 | 230 | 144395 | 63257 | 29744596 |
Anaemia vitamin B12 deficiency | 10.49 | 9.71 | 10 | 144615 | 300 | 29807553 |
Oral herpes | 10.48 | 9.71 | 46 | 144579 | 4409 | 29803444 |
Neutropenia neonatal | 10.47 | 9.71 | 13 | 144612 | 528 | 29807325 |
BK virus infection | 10.43 | 9.71 | 4 | 144621 | 4360 | 29803493 |
Scoliosis | 10.41 | 9.71 | 24 | 144601 | 1628 | 29806225 |
Hepatitis C | 10.41 | 9.71 | 31 | 144594 | 13174 | 29794679 |
Myocardial infarction | 10.40 | 9.71 | 498 | 144127 | 125127 | 29682726 |
Cardiac failure | 10.38 | 9.71 | 315 | 144310 | 83103 | 29724750 |
Transverse presentation | 10.38 | 9.71 | 6 | 144619 | 81 | 29807772 |
Abscess limb | 10.37 | 9.71 | 36 | 144589 | 3093 | 29804760 |
Hyperammonaemia | 10.30 | 9.71 | 7 | 144618 | 5513 | 29802340 |
Psychomotor retardation | 10.29 | 9.71 | 30 | 144595 | 2349 | 29805504 |
Gross motor delay | 10.29 | 9.71 | 9 | 144616 | 241 | 29807612 |
Umbilical cord around neck | 10.28 | 9.71 | 8 | 144617 | 181 | 29807672 |
Aplasia pure red cell | 10.27 | 9.71 | 54 | 144571 | 5572 | 29802281 |
Body dysmorphic disorder | 10.25 | 9.71 | 6 | 144619 | 83 | 29807770 |
Hepatic siderosis | 10.24 | 9.71 | 8 | 144617 | 182 | 29807671 |
Vomiting | 10.23 | 9.71 | 918 | 143707 | 218900 | 29588953 |
Mesothelioma | 10.21 | 9.71 | 12 | 144613 | 460 | 29807393 |
Macrosomia | 10.19 | 9.71 | 6 | 144619 | 84 | 29807769 |
Joint instability | 10.18 | 9.71 | 11 | 144614 | 384 | 29807469 |
Subdural haematoma | 10.17 | 9.71 | 52 | 144573 | 18920 | 29788933 |
Blood pressure diastolic decreased | 10.16 | 9.71 | 58 | 144567 | 6173 | 29801680 |
Disseminated intravascular coagulation | 10.14 | 9.71 | 64 | 144561 | 22107 | 29785746 |
Autosomal chromosome anomaly | 10.12 | 9.71 | 4 | 144621 | 21 | 29807832 |
Ligament laxity | 10.12 | 9.71 | 4 | 144621 | 21 | 29807832 |
Pancreatic duct stenosis | 10.06 | 9.71 | 8 | 144617 | 187 | 29807666 |
Congenital pulmonary hypertension | 10.03 | 9.71 | 5 | 144620 | 49 | 29807804 |
Large intestinal stenosis | 10.00 | 9.71 | 20 | 144605 | 1230 | 29806623 |
Ear malformation | 9.98 | 9.71 | 9 | 144616 | 251 | 29807602 |
Renal hypertrophy | 9.97 | 9.71 | 4 | 144621 | 22 | 29807831 |
Tachycardia foetal | 9.94 | 9.71 | 10 | 144615 | 321 | 29807532 |
Contraindicated product administered | 9.92 | 9.71 | 127 | 144498 | 17104 | 29790749 |
Neonatal hyponatraemia | 9.89 | 9.71 | 6 | 144619 | 89 | 29807764 |
Potentiating drug interaction | 9.87 | 9.71 | 5 | 144620 | 4626 | 29803227 |
Fracture | 9.85 | 9.71 | 56 | 144569 | 5950 | 29801903 |
Pulmonary tuberculosis | 9.83 | 9.71 | 48 | 144577 | 4809 | 29803044 |
Aplasia cutis congenita | 9.77 | 9.71 | 7 | 144618 | 139 | 29807714 |
C-reactive protein increased | 9.75 | 9.71 | 277 | 144348 | 43196 | 29764657 |
Congenital spinal cord anomaly | 9.75 | 9.71 | 3 | 144622 | 6 | 29807847 |
Pyloric stenosis | 9.72 | 9.71 | 13 | 144612 | 569 | 29807284 |
Source | Code | Description |
---|---|---|
ATC | B03BB01 | BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS VITAMIN B12 AND FOLIC ACID Folic acid and derivatives |
ATC | V04CX02 | VARIOUS DIAGNOSTIC AGENTS OTHER DIAGNOSTIC AGENTS Other diagnostic agents |
ATC | B03AE01 | BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS IRON PREPARATIONS Iron in other combinations |
ATC | B03AE02 | BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS IRON PREPARATIONS Iron in other combinations |
ATC | B03BB51 | BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS VITAMIN B12 AND FOLIC ACID Folic acid and derivatives |
MeSH PA | D006397 | Hematinics |
MeSH PA | D006401 | Hematologic Agents |
MeSH PA | D018977 | Micronutrients |
MeSH PA | D014803 | Vitamin B Complex |
MeSH PA | D014815 | Vitamins |
CHEBI has role | CHEBI:33284 | nutrients |
CHEBI has role | CHEBI:75769 | vitamin b |
CHEBI has role | CHEBI:75771 | mus musculus metabolite |
CHEBI has role | CHEBI:77746 | h. sapiens metabolites |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Megaloblastic anemia due to folate deficiency | indication | 85649008 | DOID:14026 |
Vitamin deficiency | indication | 85670002 | |
Iron deficiency anemia | indication | 87522002 | |
Mineral deficiency | indication | 111379007 | |
Folic acid deficiency | indication | 190633005 | |
Pregnancy, function | indication | 289908002 | |
Breastfeeding (mother) | indication | 413712001 | |
Vitamin Deficiency Prevention | indication | ||
Mineral Deficiency Prevention | indication | ||
Prevention of Vitamin B12 Deficiency | indication | ||
Homocystinuria | off-label use | 11282001 | DOID:9263 |
Homocystinemia | off-label use | 52311001 | |
Prevention of Fetal Neural Tube Defects during Pregnancy | off-label use | ||
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Bipolar disorder | contraindication | 13746004 | DOID:3312 |
Constipation | contraindication | 14760008 | DOID:2089 |
Operation on stomach | contraindication | 16453004 | |
Primary hyperoxaluria | contraindication | 17901006 | DOID:2977 |
Gastroenteritis | contraindication | 25374005 | DOID:2326 |
Sarcoidosis | contraindication | 31541009 | DOID:11335 |
Dehydration | contraindication | 34095006 | |
Hemosiderosis | contraindication | 39011001 | DOID:12119 |
Hypokalemia | contraindication | 43339004 | |
Gastrectomy | contraindication | 53442002 | |
Leber's optic atrophy | contraindication | 58610003 | DOID:705 |
Hemolytic anemia | contraindication | 61261009 | DOID:583 |
Diarrhea | contraindication | 62315008 | |
Ulcerative colitis | contraindication | 64766004 | DOID:8577 |
Hypercalcemia | contraindication | 66931009 | DOID:12678 |
Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Phototoxicity | contraindication | 84326006 | |
Atrophic gastritis | contraindication | 84568007 | DOID:8929 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Kidney stone | contraindication | 95570007 | |
Anemia due to enzyme deficiency | contraindication | 111577008 | |
Hb SS disease | contraindication | 127040003 | DOID:10923 |
Osteolysis | contraindication | 203522001 | |
Hypomania | contraindication | 231496004 | |
Esophageal dysmotility | contraindication | 266434009 | DOID:9192 |
Diverticular disease | contraindication | 397881000 | |
Hemochromatosis | contraindication | 399187006 | DOID:2352 |
Repeated Blood Transfusions | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 3.46 | acidic |
pKa2 | 5.15 | acidic |
pKa3 | 12.96 | acidic |
pKa4 | 4.55 | Basic |
pKa5 | 4.15 | Basic |
pKa6 | 2.28 | Basic |
pKa7 | 1.73 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Thymidylate synthase | Enzyme | Ki | 4.40 | CHEMBL | |||||
Dihydrofolate reductase | Unclassified | Kd | 6.09 | CHEMBL |
ID | Source |
---|---|
4017507 | VUID |
N0000145892 | NUI |
D00070 | KEGG_DRUG |
6484-89-5 | SECONDARY_CAS_RN |
4017507 | VANDF |
C0304894 | UMLSCUI |
CHEBI:27470 | CHEBI |
FOL | PDB_CHEM_ID |
135398658 | PUBCHEM_CID |
CHEMBL2107429 | ChEMBL_ID |
CHEMBL1622 | ChEMBL_ID |
DB00158 | DRUGBANK_ID |
D005492 | MESH_DESCRIPTOR_UI |
4563 | IUPHAR_LIGAND_ID |
68 | INN_ID |
9P9W8GGU78 | UNII |
1300473 | RXNORM |
264 | MMSL |
4759 | MMSL |
d00241 | MMSL |
001049 | NDDF |
126224002 | SNOMEDCT_US |
6247001 | SNOMEDCT_US |
63718003 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Ferralet 90 | HUMAN PRESCRIPTION DRUG LABEL | 5 | 0178-0089 | TABLET, FILM COATED | 1 mg | ORAL | unapproved drug other | 17 sections |
NataFort | HUMAN PRESCRIPTION DRUG LABEL | 10 | 0178-0716 | TABLET | 1 mg | ORAL | Unapproved drug other | 12 sections |
CitraNatal Harmony 3.0 | HUMAN PRESCRIPTION DRUG LABEL | 8 | 0178-0796 | CAPSULE, GELATIN COATED | 1 mg | ORAL | unapproved drug other | 10 sections |
CitraNatal Harmony | HUMAN PRESCRIPTION DRUG LABEL | 8 | 0178-0798 | CAPSULE, GELATIN COATED | 1 mg | ORAL | UNULLPPROVED DRUG OTHER | 11 sections |
CitraNatal Harmony | HUMAN PRESCRIPTION DRUG LABEL | 8 | 0178-0799 | CAPSULE, GELATIN COATED | 1 mg | ORAL | Unapproved drug other | 11 sections |
CitraNatal Harmony | HUMAN PRESCRIPTION DRUG LABEL | 8 | 0178-0812 | CAPSULE, GELATIN COATED | 1 mg | ORAL | Unapproved drug other | 11 sections |
CitraNatal Bloom | HUMAN PRESCRIPTION DRUG LABEL | 6 | 0178-0813 | TABLET, FILM COATED | 1.40 mg | ORAL | unapproved drug other | 15 sections |
CitraNatal 90 DHA | HUMAN PRESCRIPTION DRUG LABEL | 16 | 0178-0821 | TABLET | 1 mg | ORAL | unapproved drug other | 11 sections |
CitraNatal 90 DHA | HUMAN OTC DRUG LABEL | 14 | 0178-0829 | TABLET | 1 mg | ORAL | Unapproved drug other | 11 sections |
CitraNatal Rx | HUMAN PRESCRIPTION DRUG LABEL | 13 | 0178-0858 | TABLET | 1 mg | ORAL | Unapproved drug other | 12 sections |
CitraNatal Rx | HUMAN PRESCRIPTION DRUG LABEL | 14 | 0178-0859 | TABLET | 1 mg | ORAL | Unapproved drug other | 9 sections |
CitraNatal Medley | HUMAN PRESCRIPTION DRUG LABEL | 8 | 0178-0896 | CAPSULE, GELATIN COATED | 1 mg | ORAL | unapproved drug other | 10 sections |
CitraNatal DHA | HUMAN OTC DRUG LABEL | 14 | 0178-0898 | TABLET | 1 mg | ORAL | Unapproved drug other | 11 sections |
Folic Acid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0603-3162 | TABLET | 1 mg | ORAL | ANDA | 19 sections |
Folic Acid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7814 | TABLET | 1 mg | ORAL | ANDA | 12 sections |
VitafolOne | HUMAN PRESCRIPTION DRUG LABEL | 16 | 0642-0070 | CAPSULE, GELATIN COATED | 1 mg | ORAL | unapproved drug other | 7 sections |
Vitafol Caplet | HUMAN PRESCRIPTION DRUG LABEL | 12 | 0642-0072 | CAPSULE | 1 mg | ORAL | UNULLPPROVED DRUG OTHER | 13 sections |
Select OB | HUMAN PRESCRIPTION DRUG LABEL | 15 | 0642-0077 | TABLET, CHEWABLE | 0.40 mg | ORAL | UNULLPPROVED DRUG OTHER | 14 sections |
Vitafol OB Caplet | HUMAN PRESCRIPTION DRUG LABEL | 15 | 0642-0079 | TABLET | 1 mg | ORAL | Unapproved drug other | 14 sections |
Vitafol Plus | HUMAN PRESCRIPTION DRUG LABEL | 17 | 0642-0092 | CAPSULE, LIQUID FILLED | 1 mg | ORAL | UNULLPPROVED DRUG OTHER | 13 sections |
Vitafol Ultra | HUMAN PRESCRIPTION DRUG LABEL | 17 | 0642-0093 | CAPSULE, LIQUID FILLED | 680 ug | ORAL | UNULLPPROVED DRUG OTHER | 13 sections |
Vitafol Nano | HUMAN PRESCRIPTION DRUG LABEL | 7 | 0642-0094 | TABLET, COATED | 680 ug | ORAL | UNULLPPROVED DRUG OTHER | 14 sections |
Select OB | HUMAN PRESCRIPTION DRUG LABEL | 15 | 0642-0120 | TABLET, CHEWABLE | 0.40 mg | ORAL | UNULLPPROVED DRUG OTHER | 13 sections |
Strovite Forte Caplet | HUMAN PRESCRIPTION DRUG LABEL | 19 | 0642-0204 | TABLET, COATED | 1 mg | ORAL | UNULLPPROVED DRUG OTHER | 15 sections |
Strovite One Caplets | HUMAN PRESCRIPTION DRUG LABEL | 20 | 0642-0207 | TABLET | 1 mg | ORAL | UNULLPPROVED DRUG OTHER | 14 sections |
Reaphirm Plant Source DHA | HUMAN PRESCRIPTION DRUG LABEL | 16 | 0642-3010 | CAPSULE, GELATIN COATED | 1 mg | ORAL | unapproved drug other | 7 sections |
Vitafol | HUMAN PRESCRIPTION DRUG LABEL | 4 | 0642-7468 | STRIP | 1 mg | ORAL | Unapproved drug other | 13 sections |
Vitafol Fe Plus | HUMAN PRESCRIPTION DRUG LABEL | 17 | 0642-7473 | CAPSULE, LIQUID FILLED | 680 mg | ORAL | UNULLPPROVED DRUG OTHER | 14 sections |
Marnatal F | HUMAN PRESCRIPTION DRUG LABEL | 13 | 0682-1570 | CAPSULE | 1000 ug | ORAL | UNULLPPROVED DRUG OTHER | 4 sections |
BACMIN | HUMAN PRESCRIPTION DRUG LABEL | 19 | 0682-3001 | TABLET, COATED | 1 mg | ORAL | UNULLPPROVED DRUG OTHER | 10 sections |