folic acid Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1231 59-30-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • folic acid
  • acifolic
  • aspol
  • cytofol
  • folacid
  • pteroylglutamic acid
  • folate sodium
A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (POACEAE). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia.
  • Molecular weight: 441.40
  • Formula: C19H19N7O6
  • CLOGP: -2.04
  • LIPINSKI: 2
  • HAC: 13
  • HDO: 6
  • TPSA: 207.93
  • ALOGS: -3.74
  • ROTB: 9

Drug dosage:

DoseUnitRoute
0.40 mg O
10 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.00 mg/mL Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 11.43 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 75 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 9.70 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 52 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.50 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Aug. 13, 1946 FDA LEDERLE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 1020.67 9.73 3750 311697 236465 46134150
Pemphigus 871.03 9.73 1288 314159 43986 46326629
Systemic lupus erythematosus 745.12 9.73 1471 313976 63709 46306906
Completed suicide 729.48 9.73 71 315376 145849 46224766
Maternal exposure during pregnancy 621.88 9.73 1809 313638 100740 46269875
Glossodynia 562.99 9.73 1047 314400 43326 46327289
Exposure during pregnancy 455.23 9.73 1686 313761 106526 46264089
Hand deformity 420.12 9.73 801 314646 33773 46336842
Toxicity to various agents 381.79 9.73 524 314923 211242 46159373
Death 346.16 9.73 1139 314308 334409 46036206
Arthropathy 329.11 9.73 1287 314160 83413 46287202
Alopecia 324.26 9.73 2041 313406 160373 46210242
Gestational diabetes 315.88 9.73 312 315135 6907 46363708
Infusion related reaction 308.17 9.73 1428 314019 99780 46270835
Abdominal discomfort 292.02 9.73 1884 313563 149281 46221334
Joint swelling 285.62 9.73 2011 313436 164062 46206553
Foetal exposure during pregnancy 281.40 9.73 634 314813 30113 46340502
Drug abuse 280.02 9.73 46 315401 63362 46307253
Wound 267.74 9.73 764 314683 42038 46328577
Pain 260.11 9.73 4593 310854 472355 45898260
Arthralgia 250.71 9.73 3650 311797 360953 46009662
Intentional overdose 238.71 9.73 71 315376 64873 46305742
Synovitis 225.07 9.73 913 314534 60162 46310453
Drug hypersensitivity 203.01 9.73 902 314545 242923 46127692
Anti-cyclic citrullinated peptide antibody positive 200.59 9.73 417 315030 18728 46351887
Small for dates baby 197.09 9.73 177 315270 3460 46367155
Contraindicated product administered 194.50 9.73 1059 314388 78888 46291727
Pericarditis 192.33 9.73 469 314978 23458 46347157
Overdose 171.11 9.73 265 315182 101714 46268901
Rheumatoid factor positive 169.74 9.73 406 315041 20055 46350560
Swelling 167.26 9.73 1424 314023 123087 46247528
Suicide attempt 160.08 9.73 86 315361 54950 46315665
Hip arthroplasty 159.63 9.73 368 315079 17744 46352871
Nasopharyngitis 157.45 9.73 1662 313785 152336 46218279
Abortion spontaneous 155.66 9.73 646 314801 43000 46327615
Product use issue 154.33 9.73 1132 314315 93512 46277103
Cardiac arrest 152.52 9.73 234 315213 90165 46280450
Pregnancy 146.58 9.73 460 314987 26677 46343938
Knee arthroplasty 142.72 9.73 417 315030 23248 46347367
Red blood cell sedimentation rate abnormal 142.64 9.73 297 315150 13352 46357263
Febrile neutropenia 138.57 9.73 268 315179 94359 46276256
Sickle cell anaemia with crisis 134.37 9.73 150 315297 3842 46366773
Musculoskeletal stiffness 133.82 9.73 1125 314322 96868 46273747
C-reactive protein abnormal 133.29 9.73 380 315067 20890 46349725
Drug interaction 131.04 9.73 819 314628 202275 46168340
Discomfort 117.37 9.73 624 314823 46046 46324569
Injection site erythema 117.21 9.73 883 314564 73544 46297071
Device expulsion 117.16 9.73 22 315425 27520 46343095
Malignant neoplasm progression 115.43 9.73 162 315285 64764 46305851
Depressed level of consciousness 105.91 9.73 99 315348 47470 46323145
Respiratory arrest 101.06 9.73 51 315396 33765 46336850
Disease progression 100.78 9.73 300 315147 91000 46279615
Atrial septal defect 97.83 9.73 163 315284 6169 46364446
Injection site pruritus 97.63 9.73 528 314919 39215 46331400
Injection site pain 97.32 9.73 1130 314317 106022 46264593
Caesarean section 95.77 9.73 288 315159 16315 46354300
Bradycardia 91.71 9.73 194 315253 66104 46304511
Anxiety 89.90 9.73 791 314656 181166 46189449
Arthritis 89.30 9.73 856 314591 76460 46294155
Blood pressure fluctuation 87.71 9.73 423 315024 30025 46340590
Basal cell carcinoma 85.80 9.73 319 315128 20168 46350447
Psoriatic arthropathy 85.80 9.73 478 314969 35901 46334714
Acute kidney injury 84.76 9.73 1104 314343 234751 46135864
Dyspnoea 84.39 9.73 2749 312698 512799 45857816
Respiratory disorder neonatal 81.79 9.73 60 315387 868 46369747
Agitation 81.05 9.73 157 315290 55258 46315357
Ventricular septal defect 80.72 9.73 117 315330 3917 46366698
Injection site swelling 80.39 9.73 507 314940 39820 46330795
Therapeutic product effect decreased 79.91 9.73 882 314565 81719 46288896
Pancytopenia 78.10 9.73 899 314548 84159 46286456
Cardio-respiratory arrest 78.04 9.73 181 315266 59688 46310927
Duodenal ulcer perforation 76.30 9.73 174 315273 8328 46362287
Pre-eclampsia 75.54 9.73 167 315280 7827 46362788
Premature delivery 75.05 9.73 322 315125 21747 46348868
Dizziness 74.74 9.73 1741 313706 338673 46031942
Injection site reaction 74.36 9.73 566 314881 47283 46323332
Nausea 74.06 9.73 3846 311601 683608 45687007
Osteoarthritis 73.75 9.73 691 314756 61334 46309281
Electrocardiogram QT prolonged 72.83 9.73 148 315299 51177 46319438
Live birth 72.11 9.73 192 315255 10138 46360477
Tremor 71.59 9.73 472 314975 115167 46255448
Asthma 70.50 9.73 348 315099 91194 46279421
Product quality issue 69.48 9.73 83 315364 35565 46335050
Helicobacter infection 69.03 9.73 205 315242 11531 46359084
Premature labour 68.98 9.73 200 315247 11099 46359516
Cardiac failure 67.43 9.73 294 315153 79654 46290961
Drug withdrawal syndrome 67.05 9.73 52 315395 27332 46343283
Disability assessment scale score increased 66.91 9.73 79 315368 2153 46368462
Joint effusion 66.31 9.73 205 315242 11790 46358825
Lactic acidosis 66.03 9.73 79 315368 33830 46336785
Drug dependence 64.14 9.73 27 315420 19874 46350741
Multiple sclerosis relapse 63.66 9.73 117 315330 42008 46328607
Insomnia 63.31 9.73 761 314686 164163 46206452
Intentional self-injury 62.93 9.73 43 315404 24123 46346492
Rhabdomyolysis 62.80 9.73 117 315330 41792 46328823
Sedation 59.35 9.73 41 315406 22869 46347746
Joint laxity 57.63 9.73 71 315376 2025 46368590
Impaired healing 57.29 9.73 435 315012 36308 46334307
Constipation 56.73 9.73 831 314616 173266 46197349
Renal failure 55.97 9.73 494 314953 113100 46257515
Somnolence 54.21 9.73 738 314709 155783 46214832
Maternal drugs affecting foetus 52.96 9.73 116 315331 5402 46365213
Red blood cell sedimentation rate increased 52.80 9.73 299 315148 22590 46348025
Intentional product misuse 51.88 9.73 155 315292 46973 46323642
Localised infection 51.71 9.73 306 315141 23495 46347120
Neck deformity 51.29 9.73 63 315384 1791 46368824
Premature rupture of membranes 50.67 9.73 100 315347 4323 46366292
Drug reaction with eosinophilia and systemic symptoms 50.27 9.73 76 315371 29472 46341143
Blood pressure diastolic abnormal 50.17 9.73 123 315324 6171 46364444
Confusional state 50.08 9.73 769 314678 159123 46211492
Diarrhoea 50.07 9.73 3186 312261 556416 45814199
Tachycardia 50.07 9.73 431 315016 99191 46271424
Palmar-plantar erythrodysaesthesia syndrome 49.86 9.73 39 315408 20412 46350203
Psoriasis 49.83 9.73 777 314670 77827 46292788
Lower respiratory tract infection 48.66 9.73 578 314869 54511 46316104
Dysmorphism 48.30 9.73 62 315385 1845 46368770
Foetal death 47.93 9.73 149 315298 8594 46362021
Hypotension 47.81 9.73 1201 314246 231388 46139227
Neuropathy peripheral 47.59 9.73 389 315058 90504 46280111
Talipes 47.58 9.73 53 315394 1354 46369261
Myalgia 47.58 9.73 567 314880 122521 46248094
Drug ineffective 47.50 9.73 5250 310197 672588 45698027
Treatment failure 47.34 9.73 888 314559 92199 46278416
Herpes zoster 47.33 9.73 682 314765 67190 46303425
Hepatic enzyme increased 47.20 9.73 796 314651 80991 46289624
Congenital umbilical hernia 46.93 9.73 33 315414 445 46370170
Sopor 46.86 9.73 39 315408 19789 46350826
Hyperhidrosis 46.86 9.73 382 315065 88926 46281689
Juvenile idiopathic arthritis 46.83 9.73 93 315354 4039 46366576
Tuberculosis 46.51 9.73 164 315283 10101 46360514
Developmental hip dysplasia 46.29 9.73 50 315397 1233 46369382
Hepatic failure 46.02 9.73 98 315349 33318 46337297
Neutropenia 45.78 9.73 686 314761 142518 46228097
Hyponatraemia 45.48 9.73 451 314996 100881 46269734
Neoplasm progression 45.04 9.73 69 315378 26614 46344001
Injection site bruising 44.36 9.73 401 315046 35235 46335380
Cardiac failure congestive 44.31 9.73 401 315046 91349 46279266
Rheumatoid nodule 44.27 9.73 148 315299 8872 46361743
Malignant melanoma 44.23 9.73 161 315286 10073 46360542
Osteoporosis 44.13 9.73 444 315003 40164 46330451
Injection site rash 43.61 9.73 217 315230 15596 46355019
Pulmonary arterial hypertension 42.86 9.73 68 315379 25860 46344755
Premature baby 42.71 9.73 238 315209 17874 46352741
Drug resistance 42.50 9.73 33 315414 17335 46353280
Foot deformity 42.07 9.73 211 315236 15214 46355401
Coma 41.98 9.73 227 315220 58122 46312493
Poisoning 41.97 9.73 21 315426 13973 46356642
Urticaria 41.84 9.73 553 314894 117339 46253276
Therapeutic response decreased 41.84 9.73 461 314986 42684 46327931
Loss of personal independence in daily activities 41.64 9.73 579 314868 56604 46314011
Vomiting 41.63 9.73 2571 312876 450223 45920392
Sinusitis 41.32 9.73 1159 314288 128609 46242006
Infective pulmonary exacerbation of cystic fibrosis 41.21 9.73 11 315436 10796 46359819
Hypoglycaemia 40.46 9.73 209 315238 54140 46316475
Asthenia 39.70 9.73 1708 313739 309367 46061248
Depression 39.49 9.73 862 314585 169242 46201373
Skin ulcer 39.26 9.73 363 315084 32095 46338520
Blood pressure systolic abnormal 38.97 9.73 103 315344 5414 46365201
Cytomegalovirus infection 38.94 9.73 39 315408 18105 46352510
Hyperglycaemia 38.85 9.73 115 315332 34956 46335659
Oropharyngeal pain 38.56 9.73 710 314737 73458 46297157
Blood glucose increased 38.24 9.73 307 315140 71706 46298909
Hypoxia 38.22 9.73 200 315247 51638 46318977
Diabetic ketoacidosis 38.11 9.73 40 315407 18170 46352445
Plasma cell myeloma 37.84 9.73 163 315284 44315 46326300
Emotional distress 37.51 9.73 96 315351 30611 46340004
Pulmonary tuberculosis 37.23 9.73 92 315355 4639 46365976
Condition aggravated 37.03 9.73 2017 313430 243035 46127580
No adverse event 36.66 9.73 114 315333 34117 46336498
Serotonin syndrome 35.95 9.73 68 315379 24152 46346463
Decreased appetite 35.60 9.73 1017 314430 192819 46177796
Bone erosion 35.42 9.73 142 315305 9301 46361314
Fluid retention 35.41 9.73 201 315246 50845 46319770
Oral herpes 35.11 9.73 238 315209 19152 46351463
Anaphylactic reaction 34.79 9.73 213 315234 52899 46317716
Fracture 34.65 9.73 210 315237 16261 46354354
Mental status changes 34.64 9.73 136 315311 37952 46332663
Syncope 34.54 9.73 499 314948 104304 46266311
Mydriasis 34.52 9.73 14 315433 10539 46360076
Respiratory failure 34.28 9.73 443 315004 94373 46276242
Renal impairment 34.21 9.73 329 315118 74043 46296572
Limb deformity 34.12 9.73 75 315372 3501 46367114
Neutrophil count decreased 33.46 9.73 165 315282 43261 46327354
Myocardial infarction 32.97 9.73 462 314985 97066 46273549
Hallucination 32.88 9.73 200 315247 49751 46320864
Blood creatine phosphokinase increased 32.86 9.73 88 315359 27636 46342979
Feeling abnormal 32.81 9.73 621 314826 124439 46246176
Inflammation 32.76 9.73 487 314960 48294 46322321
Metastases to bone 32.68 9.73 42 315405 17434 46353181
Arthritis infective 32.66 9.73 92 315355 5021 46365594
Polyhydramnios 31.61 9.73 52 315395 1947 46368668
Nodule 31.59 9.73 197 315250 15408 46355207
Placental disorder 31.36 9.73 43 315404 1366 46369249
Neck mass 31.35 9.73 69 315378 3224 46367391
Metabolic acidosis 31.25 9.73 145 315302 38635 46331980
Joint destruction 31.23 9.73 66 315381 2998 46367617
Latent tuberculosis 31.01 9.73 51 315396 1909 46368706
Musculoskeletal pain 30.96 9.73 655 314792 69473 46301142
Congenital hydronephrosis 30.96 9.73 24 315423 379 46370236
Muscle spasms 30.87 9.73 616 314831 122497 46248118
Femur fracture 30.85 9.73 384 315063 36613 46334002
Injection site warmth 30.52 9.73 178 315269 13594 46357021
Polyarthritis 30.05 9.73 105 315342 6437 46364178
Blood pressure diastolic decreased 29.77 9.73 181 315266 14030 46356585
Ejection fraction decreased 29.68 9.73 47 315400 17890 46352725
Grip strength decreased 29.59 9.73 126 315321 8480 46362135
Hypotonia neonatal 29.50 9.73 33 315414 847 46369768
Blood pressure systolic increased 29.49 9.73 311 315136 28476 46342139
Influenza 29.44 9.73 801 314646 88469 46282146
Shock 29.30 9.73 65 315382 21780 46348835
Smear cervix abnormal 28.96 9.73 57 315390 2459 46368156
Abnormal behaviour 28.79 9.73 62 315385 20996 46349619
Hepatic function abnormal 28.75 9.73 127 315320 34294 46336321
Ventricular tachycardia 28.52 9.73 44 315403 16923 46353692
Respiratory depression 28.43 9.73 22 315425 11578 46359037
Cellulitis 28.33 9.73 648 314799 69640 46300975
Patent ductus arteriosus 28.20 9.73 73 315374 3789 46366826
Wheezing 28.15 9.73 228 315219 53158 46317457
Synovial cyst 27.98 9.73 111 315336 7235 46363380
Bronchitis 27.95 9.73 925 314522 105054 46265561
Amniotic fluid volume increased 27.74 9.73 16 315431 149 46370466
Neonatal hypoxia 27.19 9.73 24 315423 458 46370157
Serum ferritin increased 27.10 9.73 88 315359 5195 46365420
Multiple fractures 27.01 9.73 91 315356 5476 46365139
Schizophrenia 27.01 9.73 12 315435 8556 46362059
Acute hepatic failure 26.89 9.73 36 315411 14685 46355930
Dyspnoea exertional 26.87 9.73 214 315233 50075 46320540
Exomphalos 26.80 9.73 25 315422 514 46370101
Enthesopathy 26.71 9.73 81 315366 4609 46366006
Low birth weight baby 26.52 9.73 89 315358 5345 46365270
Foetal growth restriction 26.45 9.73 101 315346 6466 46364149
Seizure 26.44 9.73 631 314816 122423 46248192
Heart rate decreased 26.33 9.73 329 315118 31394 46339221
Foetal anticonvulsant syndrome 26.32 9.73 23 315424 433 46370182
Drug level increased 26.30 9.73 53 315394 18388 46352227
Encephalopathy 26.24 9.73 127 315320 33462 46337153
Agitation neonatal 26.23 9.73 24 315423 481 46370134
Dysgeusia 26.19 9.73 163 315284 40328 46330287
Delirium 26.14 9.73 146 315301 37082 46333533
Neuroleptic malignant syndrome 26.13 9.73 22 315425 11100 46359515
Pain in jaw 26.12 9.73 152 315295 38220 46332395
Joint stiffness 25.98 9.73 289 315158 26819 46343796
Immunosuppression 25.94 9.73 110 315337 7390 46363225
Speech disorder 25.85 9.73 141 315306 36026 46334589
Peripheral swelling 25.84 9.73 1311 314136 156760 46213855
Blood pressure diastolic increased 25.83 9.73 94 315353 5880 46364735
Angioedema 25.65 9.73 158 315289 39184 46331431
Skin papilloma 25.57 9.73 74 315373 4102 46366513
Restlessness 25.26 9.73 88 315359 25436 46345179
Suicidal ideation 25.26 9.73 251 315196 56131 46314484
Abortion late 25.15 9.73 14 315433 121 46370494
Vision blurred 25.05 9.73 383 315064 79325 46291290
Skin cancer 24.99 9.73 122 315325 8701 46361914
Swollen joint count increased 24.81 9.73 52 315395 2348 46368267
Mouth ulceration 24.78 9.73 284 315163 26548 46344067
Tenosynovitis stenosans 24.71 9.73 46 315401 1903 46368712
Joint range of motion decreased 24.67 9.73 181 315266 14943 46355672
Osteonecrosis of jaw 24.65 9.73 134 315313 34268 46336347
Fibromyalgia 24.47 9.73 364 315083 36099 46334516
Brain oedema 24.37 9.73 29 315418 12449 46358166
Ventricular fibrillation 24.34 9.73 25 315422 11471 46359144
Rheumatic fever 24.21 9.73 57 315390 2786 46367829
C-reactive protein increased 24.19 9.73 542 314905 58048 46312567
Breast feeding 24.15 9.73 30 315417 863 46369752
Hypothermia 24.13 9.73 28 315419 12155 46358460
Squamous cell carcinoma 24.12 9.73 111 315336 7725 46362890
Multiple organ dysfunction syndrome 24.09 9.73 228 315219 51482 46319133
Muscle spasticity 24.08 9.73 25 315422 11415 46359200
Postoperative wound infection 24.05 9.73 120 315327 8633 46361982
Chest discomfort 24.05 9.73 447 315000 89822 46280793
Large for dates baby 24.04 9.73 22 315425 441 46370174
Akathisia 24.01 9.73 11 315436 7703 46362912
Loss of consciousness 23.82 9.73 553 314894 107685 46262930
Aspartate aminotransferase increased 23.77 9.73 381 315066 78319 46292296
Pain in extremity 23.77 9.73 2043 313404 256637 46113978
Palpitations 23.47 9.73 478 314969 94781 46275834
Altered state of consciousness 23.44 9.73 80 315367 23268 46347347
Blood creatinine increased 23.37 9.73 369 315078 76034 46294581
Blood pressure decreased 23.35 9.73 260 315187 56899 46313716
Metastases to liver 23.33 9.73 62 315385 19523 46351092
Maternal exposure before pregnancy 23.31 9.73 75 315372 4406 46366209
Drug intolerance 23.30 9.73 1216 314231 145833 46224782
Extrapyramidal disorder 23.30 9.73 25 315422 11243 46359372
Unresponsive to stimuli 23.23 9.73 125 315322 32049 46338566
Complication of device insertion 23.18 9.73 3 315444 4941 46365674
Product use in unapproved indication 23.13 9.73 450 314997 89823 46280792
Normal newborn 23.12 9.73 91 315356 5910 46364705
Balance disorder 23.12 9.73 302 315145 64219 46306396
Induced labour 23.08 9.73 30 315417 904 46369711
Stillbirth 23.07 9.73 96 315351 6395 46364220
Pulmonary embolism 23.00 9.73 558 314889 108027 46262588
Posterior reversible encephalopathy syndrome 22.92 9.73 42 315405 15099 46355516
Dysarthria 22.71 9.73 154 315293 37344 46333271
Abortion missed 22.35 9.73 39 315408 1533 46369082
Arthritis bacterial 22.11 9.73 87 315360 5649 46364966
Tenderness 22.06 9.73 192 315255 16689 46353926
Oligohydramnios 21.97 9.73 84 315363 5381 46365234
Acute chest syndrome 21.96 9.73 23 315424 547 46370068
Torsade de pointes 21.92 9.73 30 315417 12124 46358491
Memory impairment 21.85 9.73 379 315068 76958 46293657
Psychotic disorder 21.72 9.73 79 315368 22542 46348073
Neurotoxicity 21.71 9.73 37 315410 13680 46356935
Device dislocation 21.69 9.73 75 315372 21727 46348888
Cholestasis of pregnancy 21.62 9.73 32 315415 1092 46369523
Gastroenteritis viral 21.59 9.73 202 315245 17917 46352698
Weight increased 21.59 9.73 1337 314110 163136 46207479
Placental insufficiency 21.56 9.73 35 315412 1296 46369319
Haemorrhage in pregnancy 21.36 9.73 39 315408 1589 46369026
Cerebral haemorrhage neonatal 21.18 9.73 13 315434 137 46370478
Product adhesion issue 20.98 9.73 4 315443 4951 46365664
Blood bilirubin increased 20.89 9.73 140 315307 34044 46336571
Maternal exposure during breast feeding 20.65 9.73 53 315394 2736 46367879
Synovial fluid analysis 20.64 9.73 35 315412 1344 46369271
Alanine aminotransferase increased 20.57 9.73 448 314999 88003 46282612
Oedema 20.49 9.73 324 315123 66747 46303868
Twin pregnancy 20.42 9.73 32 315415 1149 46369466
Respiratory disorder 20.31 9.73 105 315342 27195 46343420
Scleritis 20.20 9.73 54 315393 2858 46367757
Fear 20.19 9.73 50 315397 16122 46354493
Transplant rejection 20.17 9.73 21 315426 9575 46361040
White blood cell count decreased 20.03 9.73 591 314856 111640 46258975
Birth mark 19.94 9.73 15 315432 226 46370389
Disturbance in attention 19.92 9.73 128 315319 31432 46339183
Clear cell renal cell carcinoma 19.59 9.73 29 315418 990 46369625
Graft versus host disease 19.58 9.73 10 315437 6578 46364037
Cerebrovascular accident 19.58 9.73 526 314921 100513 46270102
Surgery 19.57 9.73 288 315159 28497 46342118
Contusion 19.46 9.73 749 314698 86738 46283877
Ascites 19.40 9.73 156 315291 36428 46334187
Anaphylactic shock 19.33 9.73 71 315376 20203 46350412
Mania 19.33 9.73 27 315420 10819 46359796
Injury 19.30 9.73 197 315250 43830 46326785
Abortion threatened 19.26 9.73 22 315425 578 46370037
Immunodeficiency 19.23 9.73 153 315294 12953 46357662
Gestational hypertension 19.22 9.73 44 315403 2111 46368504
Bradyphrenia 19.21 9.73 9 315438 6221 46364394
Body height below normal 19.19 9.73 40 315407 1799 46368816
Injection site haematoma 19.13 9.73 87 315360 6025 46364590
Hospitalisation 19.09 9.73 307 315140 63078 46307537
Disorientation 18.86 9.73 159 315288 36759 46333856
Loose body in joint 18.80 9.73 29 315418 1027 46369588
Blood alkaline phosphatase increased 18.73 9.73 174 315273 39435 46331180
Bronchioloalveolar carcinoma 18.71 9.73 10 315437 79 46370536
Antinuclear antibody positive 18.63 9.73 88 315359 6192 46364423
Neonatal respiratory distress syndrome 18.62 9.73 48 315399 2485 46368130
Haemorrhage 18.51 9.73 260 315187 54609 46316006
Bronchospasm 18.50 9.73 50 315397 15657 46354958
Diverticulitis 18.48 9.73 320 315127 32719 46337896
Substance abuse 18.44 9.73 3 315444 4164 46366451
Fluid overload 18.34 9.73 108 315339 27077 46343538
Platelet count decreased 18.28 9.73 525 314922 99499 46271116
Arrhythmia 18.27 9.73 149 315298 34692 46335923
Congenital arterial malformation 18.21 9.73 17 315430 350 46370265
Breast cancer metastatic 18.10 9.73 41 315406 13637 46356978
Atrioventricular block complete 18.02 9.73 15 315432 7612 46363003
Metastases to central nervous system 18.01 9.73 30 315417 11191 46359424
Cushingoid 18.00 9.73 87 315360 6179 46364436
Nightmare 17.97 9.73 55 315392 16543 46354072
Disability 17.93 9.73 124 315323 10043 46360572
Foetal distress syndrome 17.70 9.73 31 315416 1222 46369393
Hypomania 17.64 9.73 4 315443 4384 46366231
Acute graft versus host disease 17.61 9.73 3 315444 4027 46366588
Multiple sclerosis 17.52 9.73 97 315350 24694 46345921
Foot fracture 17.52 9.73 206 315241 19376 46351239
Device difficult to use 17.41 9.73 17 315430 7987 46362628
Inappropriate antidiuretic hormone secretion 17.29 9.73 44 315403 14058 46356557
Anaemia macrocytic 17.21 9.73 48 315399 2605 46368010
Joint noise 17.18 9.73 54 315393 3133 46367482
Failed induction of labour 17.15 9.73 16 315431 329 46370286
B-cell lymphoma 17.02 9.73 55 315392 3239 46367376
Irritability 16.97 9.73 120 315327 28826 46341789
Fatigue 16.93 9.73 4489 310958 604208 45766407
Antibody test positive 16.93 9.73 42 315405 2123 46368492
Cholecystitis chronic 16.91 9.73 28 315419 10471 46360144
Lymphoma 16.91 9.73 119 315328 9694 46360921
Hypokalaemia 16.86 9.73 459 314988 87565 46283050
Coagulopathy 16.85 9.73 66 315381 18433 46352182
Venoocclusive liver disease 16.84 9.73 4 315443 4247 46366368
Febrile bone marrow aplasia 16.84 9.73 13 315434 6849 46363766
Complication associated with device 16.83 9.73 51 315396 15390 46355225
Product administration error 16.81 9.73 72 315375 19609 46351006
Autoimmune haemolytic anaemia 16.75 9.73 65 315382 4193 46366422
Fracture delayed union 16.71 9.73 42 315405 2140 46368475
Aggression 16.62 9.73 88 315359 22656 46347959
Post transplant lymphoproliferative disorder 16.57 9.73 3 315444 3853 46366762
Erythema multiforme 16.47 9.73 25 315422 9679 46360936
Wheelchair user 16.44 9.73 62 315385 3946 46366669
Injection site haemorrhage 16.43 9.73 213 315234 20496 46350119
Blood iron increased 16.36 9.73 31 315416 1300 46369315
Chest pain 16.33 9.73 1000 314447 175324 46195291
Poor venous access 16.27 9.73 104 315343 8204 46362411
Anhedonia 16.25 9.73 28 315419 10307 46360308
Synovial disorder 16.24 9.73 24 315423 818 46369797
International normalised ratio increased 16.22 9.73 221 315226 46662 46323953
Breech presentation 16.20 9.73 28 315419 1092 46369523
Tumour lysis syndrome 16.17 9.73 15 315432 7221 46363394
Disseminated tuberculosis 16.12 9.73 48 315399 2704 46367911
Injection site urticaria 16.10 9.73 137 315310 11830 46358785
Laryngitis 16.07 9.73 113 315334 9203 46361412
Respiratory distress 16.06 9.73 138 315309 31778 46338837
Congenital hypertrichosis 16.02 9.73 4 315443 0 46370615
Cystitis 15.96 9.73 386 315061 41855 46328760
Disseminated intravascular coagulation 15.95 9.73 70 315377 18935 46351680
Crying 15.90 9.73 81 315366 21060 46349555
Tonsillitis 15.79 9.73 71 315376 4893 46365722
Injection site irritation 15.70 9.73 64 315383 4223 46366392
Hiatus hernia 15.70 9.73 191 315256 18111 46352504
Withdrawal syndrome 15.70 9.73 66 315381 18068 46352547
Pulmonary fibrosis 15.67 9.73 206 315241 19886 46350729
Hypoglycaemia neonatal 15.65 9.73 25 315422 913 46369702
Haemoglobin decreased 15.60 9.73 1041 314406 127908 46242707
Obstructive airways disorder 15.57 9.73 43 315404 13369 46357246
Congenital musculoskeletal anomaly 15.39 9.73 17 315430 430 46370185
Pulmonary hypertension 15.39 9.73 162 315285 35831 46334784
Cervical incompetence 15.38 9.73 20 315427 603 46370012
Status epilepticus 15.36 9.73 46 315401 13933 46356682
Hypoplastic left heart syndrome 15.35 9.73 12 315435 192 46370423
Preterm premature rupture of membranes 15.32 9.73 26 315421 999 46369616
Human antichimeric antibody positive 15.32 9.73 31 315416 1365 46369250
Drug ineffective for unapproved indication 15.31 9.73 58 315389 16355 46354260
Tardive dyskinesia 15.30 9.73 17 315430 7526 46363089
Lung neoplasm malignant 15.24 9.73 166 315281 15323 46355292
Folate deficiency 15.24 9.73 35 315412 1683 46368932
Pulmonary oedema 15.23 9.73 248 315199 50857 46319758
Gamma-glutamyltransferase increased 15.19 9.73 139 315308 31601 46339014
Bone pain 15.18 9.73 224 315223 46666 46323949
Ketoacidosis 15.13 9.73 4 315443 3951 46366664
Hyperlipidaemia 15.12 9.73 69 315378 18470 46352145
Hyperbilirubinaemia neonatal 15.00 9.73 15 315432 337 46370278
Dactylitis 14.93 9.73 28 315419 1165 46369450
Glycosylated haemoglobin increased 14.89 9.73 32 315415 10844 46359771
Mood altered 14.88 9.73 42 315405 12965 46357650
Autism spectrum disorder 14.86 9.73 19 315428 563 46370052
Flushing 14.81 9.73 328 315119 64286 46306329
Haematotoxicity 14.76 9.73 15 315432 6918 46363697
Chronic kidney disease 14.75 9.73 191 315256 40680 46329935
Dehydration 14.73 9.73 905 314542 158635 46211980
Post procedural infection 14.68 9.73 94 315353 7419 46363196
Device use error 14.68 9.73 8 315439 5073 46365542
Face oedema 14.62 9.73 73 315374 19080 46351535
Sickle cell anaemia 14.61 9.73 19 315428 573 46370042
Dyskinesia 14.58 9.73 125 315322 28800 46341815
Aspergillus infection 14.57 9.73 15 315432 6875 46363740
Congenital tricuspid valve atresia 14.56 9.73 7 315440 43 46370572
Spinal stenosis 14.53 9.73 139 315308 12404 46358211
Asphyxia 14.51 9.73 9 315438 5317 46365298
Bursitis 14.47 9.73 201 315246 19641 46350974
Complication of device removal 14.40 9.73 3 315444 3487 46367128
Second primary malignancy 14.30 9.73 14 315433 6570 46364045
Catheter site pain 14.27 9.73 4 315443 3802 46366813
Pathogen resistance 14.22 9.73 12 315435 6048 46364567
Atrioventricular block 14.21 9.73 15 315432 6796 46363819
Pharyngitis streptococcal 14.19 9.73 102 315345 8366 46362249
Fine motor skill dysfunction 14.16 9.73 56 315391 3644 46366971
Muscular weakness 14.14 9.73 493 314954 91351 46279264
Chondropathy 14.14 9.73 37 315410 1933 46368682
Cerebral haemorrhage 14.13 9.73 123 315324 28248 46342367
Neonatal asphyxia 14.08 9.73 12 315435 218 46370397
Transplant dysfunction 14.08 9.73 7 315440 4675 46365940
Tremor neonatal 14.04 9.73 9 315438 103 46370512
Catatonia 14.02 9.73 4 315443 3758 46366857
Impaired quality of life 14.01 9.73 51 315396 3191 46367424
Hygroma colli 13.98 9.73 5 315442 12 46370603
Rotator cuff repair 13.98 9.73 31 315416 1456 46369159
Renal injury 13.97 9.73 27 315420 9514 46361101
Joint lock 13.96 9.73 38 315409 2033 46368582
Right aortic arch 13.95 9.73 13 315434 267 46370348
Pancreatitis 13.92 9.73 209 315238 43418 46327197
Haemorrhage intracranial 13.89 9.73 42 315405 12682 46357933
Morning sickness 13.88 9.73 20 315427 666 46369949
Cognitive disorder 13.82 9.73 171 315276 36712 46333903
Lymphadenectomy 13.75 9.73 23 315424 873 46369742
Lethargy 13.75 9.73 253 315194 50918 46319697
Joint warmth 13.74 9.73 28 315419 1239 46369376
Bone density abnormal 13.74 9.73 49 315398 3035 46367580
Corneal degeneration 13.73 9.73 8 315439 76 46370539
Tooth infection 13.66 9.73 135 315312 12151 46358464
Aorta hypoplasia 13.61 9.73 9 315438 109 46370506
Orthostatic hypotension 13.60 9.73 104 315343 24554 46346061
Knee operation 13.57 9.73 66 315381 4700 46365915
Cardiac failure acute 13.52 9.73 21 315426 8057 46362558
Thrombotic microangiopathy 13.52 9.73 22 315425 8284 46362331
Choanal atresia 13.48 9.73 6 315441 30 46370585
Joint dislocation 13.47 9.73 125 315322 11061 46359554
Tenosynovitis 13.46 9.73 92 315355 7423 46363192
Acute generalised exanthematous pustulosis 13.44 9.73 27 315420 9378 46361237
Joint injury 13.37 9.73 193 315254 19016 46351599
Cardiogenic shock 13.35 9.73 61 315386 16323 46354292
Complication of pregnancy 13.34 9.73 17 315430 502 46370113
Skin laceration 13.32 9.73 187 315260 18315 46352300
Benign congenital hypotonia 13.27 9.73 4 315443 4 46370611
Rash 13.26 9.73 2665 312782 353847 46016768
Wrong technique in product usage process 13.12 9.73 274 315173 54148 46316467
Myopathy 13.12 9.73 25 315422 8856 46361759
Ingrown hair 13.10 9.73 16 315431 452 46370163
Pancreatic steatosis 13.09 9.73 24 315423 981 46369634
Colitis microscopic 13.06 9.73 15 315432 6541 46364074
Bone disorder 13.06 9.73 199 315248 19834 46350781
Speech disorder developmental 12.90 9.73 15 315432 402 46370213
Drug abuser 12.89 9.73 3 315444 3230 46367385
Lupus-like syndrome 12.87 9.73 94 315353 7750 46362865
Naevus flammeus 12.82 9.73 9 315438 121 46370494
Unevaluable event 12.81 9.73 227 315220 45948 46324667
Cleft lip and palate 12.81 9.73 14 315433 350 46370265
Limb reduction defect 12.78 9.73 14 315433 351 46370264
Cholestasis 12.77 9.73 118 315329 26775 46343840
Hypoplastic right heart syndrome 12.72 9.73 7 315440 59 46370556
Tendon disorder 12.69 9.73 67 315380 4928 46365687
Infusion site erythema 12.67 9.73 20 315427 7622 46362993
Oliguria 12.64 9.73 25 315422 8734 46361881
Immune reconstitution inflammatory syndrome 12.64 9.73 12 315435 5713 46364902
Eye infection 12.57 9.73 105 315342 9018 46361597
Cyst 12.52 9.73 131 315316 11969 46358646
Threatened labour 12.50 9.73 21 315426 800 46369815
Papilloma viral infection 12.44 9.73 28 315419 1328 46369287
Dysphagia 12.37 9.73 413 315034 76899 46293716
Small cell carcinoma 12.33 9.73 10 315437 169 46370446
Panic attack 12.32 9.73 83 315364 20159 46350456
Polyneuropathy 12.31 9.73 39 315408 11605 46359010
Jaundice 12.26 9.73 130 315317 28715 46341900
Hypersensitivity 12.22 9.73 1177 314270 149144 46221471
Wound infection pseudomonas 12.20 9.73 29 315418 1426 46369189
Incorrect route of product administration 12.19 9.73 63 315384 16320 46354295
Postpartum haemorrhage 12.14 9.73 33 315414 1764 46368851
Injection site extravasation 12.11 9.73 83 315364 6702 46363913
Anterior chamber cleavage syndrome 12.09 9.73 10 315437 174 46370441
Parkinsonism 12.07 9.73 22 315425 7926 46362689
Genital haemorrhage 12.05 9.73 16 315431 6550 46364065
Infusion site pain 12.04 9.73 32 315415 10075 46360540
Blood pressure increased 12.02 9.73 1003 314444 125663 46244952
Congenital pulmonary artery anomaly 12.01 9.73 3 315444 0 46370615
Double ureter 12.01 9.73 3 315444 0 46370615
Lung neoplasm 11.96 9.73 73 315374 5667 46364948
Gastroenteritis 11.94 9.73 230 315217 23989 46346626
Hyperemesis gravidarum 11.94 9.73 16 315431 497 46370118
Catheter site erythema 11.91 9.73 6 315441 3977 46366638
Congenital cerebral cyst 11.86 9.73 10 315437 179 46370436
Vanishing twin syndrome 11.82 9.73 8 315439 101 46370514
Lung adenocarcinoma 11.81 9.73 58 315389 4146 46366469
Lordosis 11.74 9.73 12 315435 277 46370338
Pregnancy with contraceptive device 11.74 9.73 8 315439 4495 46366120
Coronary artery disease 11.71 9.73 159 315288 33593 46337022
Mycobacterium tuberculosis complex test positive 11.70 9.73 30 315417 1548 46369067
Dystonia 11.69 9.73 38 315409 11219 46359396
Injection site induration 11.68 9.73 94 315353 7985 46362630
Forceps delivery 11.68 9.73 10 315437 183 46370432
Paralysis 11.66 9.73 26 315421 8695 46361920
Hypomagnesaemia 11.64 9.73 95 315352 22115 46348500
Wound infection 11.61 9.73 114 315333 10245 46360370
Chest X-ray abnormal 11.56 9.73 53 315394 3682 46366933
Swollen tongue 11.53 9.73 134 315313 29098 46341517
Body temperature decreased 11.53 9.73 140 315307 13269 46357346
Thrombocytopenia 11.51 9.73 719 314728 125862 46244753
Ear infection 11.50 9.73 219 315228 22794 46347821
Angiocentric lymphoma 11.49 9.73 15 315432 454 46370161
Abdominal distension 11.46 9.73 393 315054 72958 46297657
Human anti-human antibody test 11.46 9.73 13 315434 339 46370276
Nervousness 11.44 9.73 130 315317 28345 46342270
Dry eye 11.43 9.73 277 315170 30045 46340570
Stress cardiomyopathy 11.42 9.73 22 315425 7762 46362853
Red blood cell sedimentation rate 11.42 9.73 32 315415 1741 46368874
Vertigo 11.42 9.73 266 315181 51782 46318833
Congenital oral malformation 11.41 9.73 10 315437 189 46370426
Hallucination, auditory 11.39 9.73 36 315411 10720 46359895
Ventricular hypoplasia 11.36 9.73 9 315438 147 46370468
Frequent bowel movements 11.35 9.73 133 315314 12499 46358116
Uterine contractions during pregnancy 11.35 9.73 16 315431 522 46370093
Viral infection 11.34 9.73 276 315171 29959 46340656
Device breakage 11.31 9.73 31 315416 9661 46360954
Vacuum extractor delivery 11.31 9.73 9 315438 148 46370467
Erysipelas 11.30 9.73 83 315364 6855 46363760
Delivery 11.23 9.73 18 315429 659 46369956
Loss of proprioception 11.16 9.73 13 315434 349 46370266
Sinus tachycardia 11.16 9.73 93 315354 21556 46349059
Hyperprolactinaemia 11.15 9.73 3 315444 2929 46367686
Renal mass 11.14 9.73 32 315415 1766 46368849
Lymphatic fistula 11.14 9.73 21 315426 877 46369738
Polychondritis 11.13 9.73 14 315433 408 46370207
Crystal nephropathy 11.13 9.73 20 315427 805 46369810
Pelvi-ureteric obstruction 11.12 9.73 8 315439 112 46370503
Abortion 11.11 9.73 37 315410 2213 46368402
Pulmonary valve stenosis congenital 11.06 9.73 9 315438 153 46370462
Pleural effusion 11.06 9.73 453 314994 82499 46288116
Inflammatory marker increased 11.01 9.73 69 315378 5406 46365209
Anger 10.98 9.73 42 315405 11810 46358805
Vascular device infection 10.97 9.73 5 315442 3512 46367103
Femoral hernia incarcerated 10.96 9.73 21 315426 888 46369727
Nail injury 10.95 9.73 14 315433 415 46370200
Congenital skin dimples 10.91 9.73 9 315438 156 46370459
Carpal tunnel syndrome 10.91 9.73 159 315288 15700 46354915
Congenital megaureter 10.86 9.73 7 315440 81 46370534
Cleft palate 10.83 9.73 21 315426 896 46369719
Limb injury 10.83 9.73 186 315261 18988 46351627
Laryngospasm 10.81 9.73 3 315444 2870 46367745
Muscle rigidity 10.79 9.73 33 315414 9928 46360687
Prothrombin consumption time prolonged 10.76 9.73 6 315441 52 46370563
Conjunctivitis 10.75 9.73 155 315292 15269 46355346
Stevens-Johnson syndrome 10.73 9.73 103 315344 23194 46347421
Headache 10.70 9.73 2974 312473 475378 45895237
Axonal neuropathy 10.70 9.73 22 315425 980 46369635
Coronary arterial stent insertion 10.70 9.73 3 315444 2850 46367765
Amniotic fluid volume decreased 10.67 9.73 14 315433 426 46370189
Endodontic procedure 10.66 9.73 39 315408 2446 46368169
Creatinine renal clearance decreased 10.65 9.73 19 315428 6901 46363714
Somnambulism 10.61 9.73 11 315436 5026 46365589
Pelvic fracture 10.59 9.73 122 315325 11417 46359198
Abortion induced 10.58 9.73 111 315336 10149 46360466
Acute respiratory failure 10.57 9.73 136 315311 29002 46341613
Respiration abnormal 10.55 9.73 9 315438 4512 46366103
Pleurisy 10.52 9.73 89 315358 7673 46362942
Renal aplasia 10.51 9.73 10 315437 211 46370404
Miosis 10.50 9.73 18 315429 6639 46363976
Syndactyly 10.49 9.73 12 315435 316 46370299
Acute myeloid leukaemia 10.47 9.73 63 315384 15715 46354900
Pyrexia 10.46 9.73 2139 313308 346663 46023952
Cartilage injury 10.46 9.73 29 315418 1568 46369047
Mucosal toxicity 10.46 9.73 12 315435 317 46370298
Gastrointestinal haemorrhage 10.43 9.73 422 315025 76951 46293664
Inflammatory pain 10.38 9.73 17 315430 634 46369981
Catheter management 10.37 9.73 3 315444 2792 46367823
Hyperkalaemia 10.34 9.73 262 315185 50447 46320168
Intestinal stenosis 10.34 9.73 39 315408 2482 46368133
Carcinoma in situ of skin 10.32 9.73 10 315437 216 46370399
Pustular psoriasis 10.29 9.73 54 315393 3963 46366652
Ulcer 10.29 9.73 170 315277 17222 46353393
Rheumatoid lung 10.29 9.73 30 315417 1670 46368945
Vascular rupture 10.26 9.73 25 315422 1249 46369366
Foetal hypokinesia 10.23 9.73 14 315433 444 46370171
Tachypnoea 10.22 9.73 56 315391 14295 46356320
Atrial fibrillation 10.20 9.73 584 314863 103006 46267609
Potentiating drug interaction 10.19 9.73 7 315440 3916 46366699
Anal prolapse 10.18 9.73 8 315439 129 46370486
Foetal heart rate deceleration abnormality 10.18 9.73 14 315433 446 46370169
Mass 10.17 9.73 122 315325 11531 46359084
Limb malformation 10.16 9.73 14 315433 447 46370168
Delusion 10.14 9.73 40 315407 11148 46359467
General physical health deterioration 10.11 9.73 660 314787 115109 46255506
Product physical issue 10.11 9.73 11 315436 4916 46365699
Decreased insulin requirement 10.08 9.73 8 315439 131 46370484
Drug screen positive 10.03 9.73 7 315440 3884 46366731
Haematocrit decreased 10.02 9.73 309 315138 34748 46335867
Off label use 10.02 9.73 2344 313103 377497 45993118
Rheumatoid factor increased 9.96 9.73 26 315421 1356 46369259
Cervix haematoma uterine 9.95 9.73 3 315444 3 46370612
Congenital oesophageal anomaly 9.95 9.73 3 315444 3 46370612
Congenital neurological disorder 9.95 9.73 3 315444 3 46370612
Gross motor delay 9.92 9.73 7 315440 95 46370520
Crohn's disease 9.91 9.73 79 315368 6692 46363923
Myofascial pain syndrome 9.86 9.73 32 315415 1889 46368726
Selective eating disorder 9.81 9.73 30 315417 1715 46368900
Teratoma benign 9.80 9.73 6 315441 63 46370552
Lip swelling 9.79 9.73 117 315330 25278 46345337

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Foetal exposure during pregnancy 780.87 9.71 926 143699 35945 29771908
Rheumatoid arthritis 415.10 9.71 727 143898 40470 29767383
Drug abuse 314.08 9.71 21 144604 82051 29725802
Completed suicide 252.21 9.71 83 144542 99409 29708444
Toxicity to various agents 250.74 9.71 292 144333 176891 29630962
Atrial septal defect 232.27 9.71 219 144406 6482 29801371
Small for dates baby 222.18 9.71 157 144468 3051 29804802
Arthralgia 170.60 9.71 1181 143444 134610 29673243
Hypospadias 167.00 9.71 123 144502 2556 29805297
Premature baby 164.65 9.71 292 144333 16399 29791454
Ventricular septal defect 139.19 9.71 124 144501 3405 29804448
Psoriatic arthropathy 113.00 9.71 241 144384 15520 29792333
Maternal exposure during pregnancy 110.85 9.71 114 144511 3757 29804096
Dysmorphism 108.91 9.71 85 144540 1932 29805921
Sickle cell anaemia with crisis 103.98 9.71 89 144536 2313 29805540
Neonatal respiratory distress syndrome 98.70 9.71 109 144516 3903 29803950
Death 95.36 9.71 1187 143438 356096 29451757
Cryptorchism 89.10 9.71 70 144555 1607 29806246
Respiratory disorder neonatal 88.96 9.71 61 144564 1127 29806726
Pancytopenia 88.04 9.71 707 143918 84345 29723508
Agitation neonatal 87.26 9.71 57 144568 968 29806885
Joint swelling 81.34 9.71 444 144181 46502 29761351
Congenital umbilical hernia 80.61 9.71 39 144586 356 29807497
Drug interaction 77.46 9.71 605 144020 198963 29608890
Maternal drugs affecting foetus 76.91 9.71 99 144526 4174 29803679
Exposure during pregnancy 76.30 9.71 150 144475 9111 29798742
Intentional overdose 73.00 9.71 56 144569 41425 29766428
Low birth weight baby 71.46 9.71 115 144510 5961 29801892
Hypoglycaemia neonatal 71.28 9.71 60 144565 1523 29806330
Tenosynovitis 70.55 9.71 86 144539 3429 29804424
Haemangioma congenital 67.35 9.71 38 144587 488 29807365
Enthesopathy 64.76 9.71 75 144550 2831 29805022
Overdose 61.66 9.71 205 144420 84132 29723721
Suicide attempt 61.49 9.71 52 144573 36645 29771208
Foetal anticonvulsant syndrome 60.95 9.71 41 144584 733 29807120
Hypotonia neonatal 59.13 9.71 45 144580 984 29806869
Syndactyly 57.89 9.71 39 144586 699 29807154
Nasopharyngitis 56.47 9.71 481 144144 58368 29749485
Talipes 54.73 9.71 53 144572 1622 29806231
Bradycardia neonatal 54.73 9.71 41 144584 875 29806978
Speech disorder developmental 53.73 9.71 45 144580 1134 29806719
Renal aplasia 53.59 9.71 36 144589 642 29807211
Musculoskeletal stiffness 53.42 9.71 326 144299 35555 29772298
Hypertonia neonatal 51.27 9.71 28 144597 336 29807517
Intentional product misuse 51.22 9.71 55 144570 34612 29773241
Hyperbilirubinaemia neonatal 50.65 9.71 35 144590 655 29807198
Patent ductus arteriosus 50.24 9.71 69 144556 3100 29804753
Blood pressure fluctuation 50.11 9.71 192 144433 17311 29790542
Drug withdrawal syndrome neonatal 48.64 9.71 68 144557 3107 29804746
Synovitis 47.86 9.71 129 144496 9654 29798199
Selective eating disorder 47.15 9.71 49 144576 1635 29806218
Hepatic function abnormal 46.44 9.71 82 144543 41863 29765990
Large for dates baby 45.54 9.71 36 144589 834 29807019
Psoriasis 44.84 9.71 355 144270 42151 29765702
Maternal exposure during breast feeding 44.82 9.71 47 144578 1585 29806268
Drug resistance 44.05 9.71 21 144604 20112 29787741
Drug reaction with eosinophilia and systemic symptoms 43.43 9.71 44 144581 28444 29779409
Developmental delay 42.35 9.71 52 144573 2089 29805764
Tongue disorder 41.82 9.71 75 144550 4247 29803606
Basal cell carcinoma 40.97 9.71 170 144455 15898 29791955
Exposure via breast milk 40.92 9.71 44 144581 1528 29806325
Drug withdrawal syndrome 39.89 9.71 23 144602 19786 29788067
Cardiac arrest 39.02 9.71 275 144350 92575 29715278
Pulmonary fibrosis 38.87 9.71 166 144459 15724 29792129
Drug dependence 38.42 9.71 28 144597 21267 29786586
Rhabdomyolysis 38.39 9.71 167 144458 63413 29744440
Coma 37.99 9.71 87 144538 40362 29767491
Caesarean section 37.66 9.71 49 144576 2088 29805765
Serotonin syndrome 37.14 9.71 20 144605 17871 29789982
Foetal growth restriction 37.00 9.71 64 144561 3521 29804332
Rheumatoid nodule 36.63 9.71 43 144582 1647 29806206
Palmar-plantar erythrodysaesthesia syndrome 36.60 9.71 13 144612 14857 29792996
Spina bifida 36.56 9.71 22 144603 321 29807532
Febrile neutropenia 36.11 9.71 335 144290 106358 29701495
Autism spectrum disorder 36.10 9.71 38 144587 1287 29806566
Foot deformity 35.01 9.71 61 144564 3376 29804477
C-reactive protein abnormal 34.99 9.71 81 144544 5512 29802341
Respiratory arrest 34.41 9.71 55 144570 29203 29778650
Agitation 33.27 9.71 141 144484 53932 29753921
Infusion related reaction 33.01 9.71 320 144305 40244 29767609
Plagiocephaly 31.97 9.71 20 144605 314 29807539
Suicidal ideation 31.30 9.71 81 144544 36033 29771820
Haemoglobin decreased 31.19 9.71 746 143879 113352 29694501
Congenital hydronephrosis 31.19 9.71 26 144599 651 29807202
Birth mark 30.29 9.71 17 144608 216 29807637
Drug intolerance 30.12 9.71 343 144282 44948 29762905
General physical health deterioration 29.96 9.71 662 143963 99282 29708571
Poisoning 29.68 9.71 9 144616 11373 29796480
Arthritis 29.22 9.71 210 144415 24191 29783662
Osteoarthritis 28.76 9.71 169 144456 18180 29789673
Renal failure 28.64 9.71 444 144181 128522 29679331
Kidney duplex 28.37 9.71 19 144606 337 29807516
Congenital tricuspid valve incompetence 28.37 9.71 14 144611 134 29807719
Intellectual disability 28.30 9.71 27 144598 811 29807042
Bradycardia 28.05 9.71 193 144432 65333 29742520
Medical device implantation 27.71 9.71 22 144603 513 29807340
Angioedema 27.64 9.71 80 144545 34304 29773549
Pain 27.51 9.71 1056 143569 171585 29636268
Blood creatine phosphokinase increased 27.18 9.71 114 144511 43734 29764119
Constipation 27.04 9.71 383 144242 112523 29695330
Delirium 26.85 9.71 103 144522 40528 29767325
Altered state of consciousness 26.84 9.71 34 144591 19885 29787968
Folate deficiency 25.84 9.71 28 144597 981 29806872
Arthropathy 25.76 9.71 180 144445 20547 29787306
Abnormal palmar/plantar creases 25.65 9.71 15 144610 207 29807646
Neonatal seizure 25.42 9.71 20 144605 460 29807393
Lower respiratory tract infection 25.42 9.71 218 144407 26496 29781357
Hyperglycaemia 25.40 9.71 86 144539 35114 29772739
Low set ears 25.34 9.71 19 144606 406 29807447
Foetal heart rate deceleration abnormality 25.22 9.71 19 144606 409 29807444
Pathogen resistance 25.14 9.71 5 144620 8405 29799448
Electrocardiogram QT prolonged 24.88 9.71 89 144536 35746 29772107
Alanine aminotransferase abnormal 24.77 9.71 45 144580 2574 29805279
Hypermobility syndrome 24.23 9.71 15 144610 231 29807622
Product use in unapproved indication 24.23 9.71 233 144392 73460 29734393
Blood pressure systolic abnormal 24.17 9.71 33 144592 1474 29806379
Skin cancer 24.17 9.71 89 144536 7872 29799981
Motor developmental delay 24.16 9.71 17 144608 328 29807525
Dermatitis psoriasiform 24.07 9.71 29 144596 1142 29806711
Pyelocaliectasis 23.93 9.71 27 144598 990 29806863
Congenital hand malformation 23.79 9.71 19 144606 447 29807406
Single umbilical artery 23.68 9.71 15 144610 241 29807612
Blood pressure systolic increased 23.57 9.71 139 144486 14971 29792882
Juvenile idiopathic arthritis 23.38 9.71 27 144598 1016 29806837
Infantile apnoea 23.34 9.71 25 144600 864 29806989
Loss of personal independence in daily activities 23.33 9.71 181 144444 21354 29786499
Disease progression 23.21 9.71 260 144365 79614 29728239
Serum ferritin increased 22.98 9.71 68 144557 5369 29802484
Knee arthroplasty 22.46 9.71 69 144556 5561 29802292
Temperature regulation disorder 22.22 9.71 19 144606 493 29807360
Weight decrease neonatal 22.20 9.71 16 144609 321 29807532
Congenital myopia 22.12 9.71 7 144618 16 29807837
Anal fistula 22.00 9.71 55 144570 3931 29803922
Infective pulmonary exacerbation of cystic fibrosis 21.95 9.71 7 144618 8565 29799288
Congenital knee deformity 21.79 9.71 9 144616 54 29807799
Congenital skin dimples 21.76 9.71 12 144613 147 29807706
Shock 21.60 9.71 49 144576 22810 29785043
Prostate cancer 21.49 9.71 193 144432 23764 29784089
Floppy infant 21.48 9.71 10 144615 83 29807770
Substance abuse 21.44 9.71 4 144621 7036 29800817
Developmental coordination disorder 21.42 9.71 8 144617 35 29807818
Product quality issue 21.42 9.71 36 144589 18738 29789115
Musculoskeletal pain 21.33 9.71 236 144389 30704 29777149
Knee deformity 21.29 9.71 16 144609 343 29807510
Polydactyly 21.27 9.71 28 144597 1207 29806646
Psychotic disorder 21.25 9.71 45 144580 21470 29786383
Cleft lip and palate 21.24 9.71 15 144610 291 29807562
Vitamin D deficiency 21.22 9.71 64 144561 5106 29802747
Congenital astigmatism 21.01 9.71 7 144618 20 29807833
Sedation 20.98 9.71 29 144596 16344 29791509
Arthritis bacterial 20.97 9.71 58 144567 4406 29803447
Urticaria 20.89 9.71 166 144459 54440 29753413
Neuroleptic malignant syndrome 20.74 9.71 29 144596 16266 29791587
Joint effusion 20.70 9.71 51 144574 3612 29804241
Somnolence 20.50 9.71 336 144289 96427 29711426
Otitis media 20.40 9.71 41 144584 2530 29805323
Immunosuppression 20.25 9.71 63 144562 5112 29802741
Pulmonary artery stenosis congenital 20.18 9.71 18 144607 495 29807358
Microcephaly 20.13 9.71 20 144605 632 29807221
Hand deformity 20.07 9.71 34 144591 1839 29806014
Joint range of motion decreased 20.03 9.71 68 144557 5777 29802076
Foetal disorder 19.97 9.71 20 144605 638 29807215
Joint laxity 19.30 9.71 9 144616 75 29807778
Post procedural infection 19.15 9.71 57 144568 4515 29803338
Sopor 19.12 9.71 15 144610 10976 29796877
Congenital bladder anomaly 18.96 9.71 14 144611 292 29807561
Cardio-respiratory arrest 18.91 9.71 181 144444 57125 29750728
Pectus excavatum 18.90 9.71 9 144616 79 29807774
Ectopic kidney 18.71 9.71 8 144617 53 29807800
Blood pressure increased 18.65 9.71 467 144158 71461 29736392
Maternal exposure before pregnancy 18.63 9.71 15 144610 357 29807496
Multiple congenital abnormalities 18.28 9.71 17 144608 494 29807359
Tendonitis 18.17 9.71 82 144543 7954 29799899
Limb malformation 17.98 9.71 14 144611 317 29807536
Tuberculosis 17.95 9.71 82 144543 7995 29799858
Lacrimal disorder 17.94 9.71 14 144611 318 29807535
Hydrocele 17.93 9.71 34 144591 2010 29805843
Cleft palate 17.58 9.71 18 144607 590 29807263
Jaundice neonatal 17.56 9.71 24 144601 1073 29806780
Tonsil cancer 17.41 9.71 20 144605 748 29807105
Language disorder 17.41 9.71 26 144599 1262 29806591
Respiratory failure 17.41 9.71 362 144263 100280 29707573
Ankyloglossia congenital 17.37 9.71 13 144612 277 29807576
Acute hepatic failure 17.20 9.71 19 144606 11808 29796045
Body temperature decreased 17.17 9.71 92 144533 9563 29798290
Hypoxia 17.16 9.71 148 144477 47706 29760147
Haematocrit decreased 17.15 9.71 225 144400 30474 29777379
Depressed level of consciousness 17.14 9.71 111 144514 38111 29769742
Pain in extremity 17.00 9.71 672 143953 109549 29698304
Pulmonary valve stenosis congenital 16.98 9.71 10 144615 140 29807713
Transposition of the great vessels 16.89 9.71 16 144609 476 29807377
Hypoglycaemia 16.83 9.71 161 144464 50820 29757033
Poor venous access 16.72 9.71 37 144588 2443 29805410
Kinematic imbalances due to suboccipital strain 16.49 9.71 6 144619 24 29807829
Microphthalmos 16.48 9.71 11 144614 194 29807659
Dyspraxia 16.43 9.71 12 144613 246 29807607
Nasal disorder 16.35 9.71 24 144601 1147 29806706
Hepatic failure 16.23 9.71 97 144528 33946 29773907
Post transplant lymphoproliferative disorder 16.19 9.71 3 144622 5303 29802550
Wound 16.18 9.71 109 144516 12293 29795560
Hallucination 16.16 9.71 155 144470 48904 29758949
Off label use 16.10 9.71 1013 143612 248277 29559576
Mean cell volume increased 15.97 9.71 33 144592 2077 29805776
Acute kidney injury 15.97 9.71 1123 143502 272719 29535134
Congenital cerebral cyst 15.93 9.71 5 144620 11 29807842
Neck mass 15.85 9.71 26 144599 1369 29806484
Hepatic cyst 15.82 9.71 36 144589 2422 29805431
Cleft lip 15.78 9.71 13 144612 320 29807533
Renal impairment 15.70 9.71 299 144326 83885 29723968
Malignant neoplasm progression 15.64 9.71 250 144375 72037 29735816
Accessory spleen 15.50 9.71 10 144615 166 29807687
Learning disorder 15.44 9.71 15 144610 461 29807392
Coarctation of the aorta 15.41 9.71 15 144610 462 29807391
Intentional self-injury 15.39 9.71 26 144599 13506 29794347
Base excess decreased 15.38 9.71 11 144614 218 29807635
Peripheral swelling 15.38 9.71 395 144230 60679 29747174
Lung neoplasm malignant 15.20 9.71 125 144500 15007 29792846
Epispadias 15.10 9.71 10 144615 174 29807679
Poikiloderma 15.05 9.71 10 144615 175 29807678
Arthrodesis 14.99 9.71 14 144611 409 29807444
Injection site pain 14.84 9.71 217 144408 30093 29777760
Maternal exposure timing unspecified 14.77 9.71 13 144612 351 29807502
Wrong technique in product usage process 14.73 9.71 89 144536 31066 29776787
Umbilical hernia 14.73 9.71 45 144580 3616 29804237
Diverticular perforation 14.65 9.71 41 144584 3136 29804717
Pulmonary valve stenosis 14.62 9.71 13 144612 356 29807497
Kyphosis congenital 14.60 9.71 4 144621 4 29807849
Incorrect route of product administration 14.54 9.71 20 144605 11295 29796558
Joint stiffness 14.53 9.71 86 144539 9275 29798578
Bronchial carcinoma 14.50 9.71 20 144605 902 29806951
Pseudolymphoma 14.44 9.71 15 144610 500 29807353
Cytomegalovirus infection 14.39 9.71 62 144563 23612 29784241
Congenital melanocytic naevus 14.36 9.71 5 144620 17 29807836
Anal atresia 14.28 9.71 12 144613 304 29807549
Grip strength decreased 14.23 9.71 32 144593 2136 29805717
Therapeutic product effect decreased 14.17 9.71 208 144417 28868 29778985
Congenital anomaly 14.17 9.71 24 144601 1298 29806555
Malignant melanoma 14.13 9.71 72 144553 7339 29800514
Blood pressure diastolic increased 14.13 9.71 37 144588 2721 29805132
Dysgraphia 14.09 9.71 26 144599 1505 29806348
Prominent epicanthal folds 14.08 9.71 9 144616 147 29807706
Septic arthritis staphylococcal 14.07 9.71 14 144611 443 29807410
Drug-induced liver injury 14.01 9.71 54 144571 21220 29786633
Plasma cell myeloma 14.00 9.71 178 144447 53284 29754569
Red blood cell sedimentation rate increased 14.00 9.71 71 144554 7224 29800629
Infection 13.97 9.71 484 144141 77590 29730263
Intraventricular haemorrhage neonatal 13.90 9.71 10 144615 200 29807653
Unresponsive to stimuli 13.83 9.71 73 144552 26346 29781507
Congenital megaureter 13.77 9.71 8 144617 109 29807744
Hydrops foetalis 13.76 9.71 11 144614 259 29807594
Emphysema 13.72 9.71 85 144540 9317 29798536
Fine motor skill dysfunction 13.69 9.71 22 144603 1139 29806714
Anxiety 13.62 9.71 330 144295 89541 29718312
Peripheral artery thrombosis 13.61 9.71 32 144593 2200 29805653
Oesophageal adenocarcinoma 13.59 9.71 19 144606 868 29806985
Toxic epidermal necrolysis 13.51 9.71 43 144582 17897 29789956
Congenital central nervous system anomaly 13.50 9.71 13 144612 395 29807458
Cerebral haemorrhage neonatal 13.41 9.71 11 144614 269 29807584
Vitamin B12 deficiency 13.40 9.71 35 144590 2570 29805283
Foetal distress syndrome 13.39 9.71 20 144605 971 29806882
Finger deformity 13.38 9.71 20 144605 972 29806881
Asthma 13.36 9.71 111 144514 36063 29771790
Pulmonary artery stenosis 13.33 9.71 9 144616 162 29807691
Joint contracture 13.29 9.71 28 144597 1787 29806066
Neutrophil count decreased 13.20 9.71 136 144489 42318 29765535
Congenital mitral valve incompetence 13.11 9.71 7 144618 80 29807773
Hypotension 13.11 9.71 814 143811 199751 29608102
Haptoglobin decreased 13.10 9.71 15 144610 559 29807294
Mouth ulceration 13.10 9.71 92 144533 10517 29797336
Injection site bruising 13.10 9.71 70 144555 7268 29800585
Ventricular fibrillation 13.08 9.71 34 144591 15104 29792749
Immunodeficiency 13.03 9.71 48 144577 4246 29803607
Ultrasound antenatal screen 13.01 9.71 3 144622 0 29807853
Umbilical granuloma 13.01 9.71 3 144622 0 29807853
Ophthalmia neonatorum 13.01 9.71 3 144622 0 29807853
Diabetic ketoacidosis 12.99 9.71 37 144588 15949 29791904
Oxygen consumption decreased 12.95 9.71 9 144616 170 29807683
Ear infection 12.93 9.71 70 144555 7304 29800549
Vascular insufficiency 12.89 9.71 12 144613 349 29807504
Venoocclusive liver disease 12.86 9.71 8 144617 6605 29801248
Aggression 12.85 9.71 115 144510 36792 29771061
Latent tuberculosis 12.82 9.71 19 144606 916 29806937
Hernia pain 12.79 9.71 10 144615 228 29807625
Skull malformation 12.73 9.71 12 144613 355 29807498
Pyrexia 12.70 9.71 1237 143388 293252 29514601
Bronchiolitis 12.70 9.71 33 144592 2415 29805438
Weight decreased 12.60 9.71 868 143757 150053 29657800
Arthritis infective 12.59 9.71 35 144590 2667 29805186
Erectile dysfunction 12.54 9.71 45 144580 18057 29789796
Strabismus 12.46 9.71 21 144604 1131 29806722
Foetal hypokinesia 12.45 9.71 12 144613 365 29807488
Blood insulin increased 12.37 9.71 12 144613 368 29807485
Reticulocytosis 12.35 9.71 11 144614 302 29807551
C-reactive protein decreased 12.33 9.71 25 144600 1553 29806300
Astigmatism 12.30 9.71 17 144608 768 29807085
Hypothermia neonatal 12.27 9.71 7 144618 92 29807761
Haemolysis 12.25 9.71 68 144557 7163 29800690
Clinodactyly 12.24 9.71 8 144617 136 29807717
Nightmare 12.14 9.71 25 144600 12051 29795802
Placental insufficiency 12.14 9.71 7 144618 94 29807759
Cystitis haemorrhagic 12.10 9.71 4 144621 4783 29803070
Cholelithiasis 12.04 9.71 150 144475 20075 29787778
Oropharyngeal pain 12.04 9.71 199 144426 28297 29779556
Sexual dysfunction 12.03 9.71 7 144618 5994 29801859
Lung cancer metastatic 12.03 9.71 33 144592 2495 29805358
Blood pressure diastolic abnormal 12.03 9.71 22 144603 1265 29806588
Neonatal respiratory distress 12.01 9.71 13 144612 455 29807398
Arnold-Chiari malformation 11.94 9.71 10 144615 252 29807601
Stevens-Johnson syndrome 11.92 9.71 44 144581 17512 29790341
JC virus CSF test positive 11.88 9.71 7 144618 98 29807755
Scleroderma renal crisis 11.88 9.71 7 144618 98 29807755
Oesophageal atresia 11.87 9.71 13 144612 461 29807392
Skin indentation 11.87 9.71 4 144621 12 29807841
Palindromic rheumatism 11.86 9.71 9 144616 196 29807657
Crohn's disease 11.85 9.71 47 144578 4305 29803548
Peritoneal tuberculosis 11.75 9.71 12 144613 392 29807461
Hypertrophy 11.71 9.71 11 144614 324 29807529
Abnormal behaviour 11.70 9.71 74 144551 25549 29782304
Lower respiratory tract congestion 11.68 9.71 19 144606 994 29806859
Sinusitis 11.66 9.71 226 144399 33119 29774734
Premature delivery 11.64 9.71 7 144618 102 29807751
Excessive cerumen production 11.61 9.71 10 144615 262 29807591
Laryngomalacia 11.61 9.71 10 144615 262 29807591
Cellulitis 11.60 9.71 302 144323 46482 29761371
Gangrene neonatal 11.51 9.71 9 144616 205 29807648
Developmental hip dysplasia 11.49 9.71 10 144615 266 29807587
Congenital musculoskeletal anomaly 11.44 9.71 9 144616 207 29807646
Pleural fibrosis 11.43 9.71 23 144602 1421 29806432
Poor sucking reflex 11.42 9.71 10 144615 268 29807585
Abnormal labour affecting foetus 11.40 9.71 4 144621 14 29807839
Injection site swelling 11.35 9.71 77 144548 8703 29799150
Scleroedema 11.34 9.71 5 144620 36 29807817
Congenital aortic valve incompetence 11.34 9.71 8 144617 155 29807698
Kidney infection 11.33 9.71 48 144577 4530 29803323
Moaning 11.31 9.71 16 144609 739 29807114
Neuroendocrine tumour of the lung metastatic 11.30 9.71 7 144618 108 29807745
Bursitis 11.28 9.71 48 144577 4538 29803315
Inguinal hernia 11.27 9.71 66 144559 7089 29800764
Intestinal stenosis 11.27 9.71 27 144598 1878 29805975
Pneumonia 11.21 9.71 1807 142818 332499 29475354
Nose deformity 11.21 9.71 8 144617 158 29807695
Duodenal atresia 11.19 9.71 4 144621 15 29807838
Prognathism 11.19 9.71 4 144621 15 29807838
Micropenis 11.12 9.71 5 144620 38 29807815
Neurotoxicity 11.09 9.71 30 144595 13152 29794701
Alcohol abuse 11.09 9.71 6 144619 5347 29802506
Delusion 11.08 9.71 26 144599 11963 29795890
Congenital diaphragmatic hernia 11.08 9.71 9 144616 217 29807636
Radiation inflammation 11.02 9.71 7 144618 113 29807740
Glycosylated haemoglobin increased 11.01 9.71 18 144607 9473 29798380
No adverse event 10.97 9.71 45 144580 17374 29790479
Urinary tract malformation 10.95 9.71 3 144622 3 29807850
Encephalocele 10.95 9.71 3 144622 3 29807850
Hernia congenital 10.95 9.71 3 144622 3 29807850
Myalgia 10.94 9.71 284 144341 76383 29731470
Thinking abnormal 10.93 9.71 6 144619 5305 29802548
Dermatitis acneiform 10.90 9.71 7 144618 5682 29802171
Tachycardia 10.83 9.71 272 144353 73467 29734386
Red blood cell count decreased 10.82 9.71 183 144442 26138 29781715
Major depression 10.82 9.71 3 144622 4019 29803834
Strabismus congenital 10.79 9.71 5 144620 41 29807812
Gastrooesophageal sphincter insufficiency 10.77 9.71 6 144619 75 29807778
Ear disorder 10.75 9.71 17 144608 868 29806985
Adenomatous polyposis coli 10.75 9.71 8 144617 169 29807684
Steatorrhoea 10.63 9.71 15 144610 691 29807162
Anti-erythropoietin antibody positive 10.63 9.71 17 144608 876 29806977
Foetal heart rate abnormal 10.63 9.71 8 144617 172 29807681
Meconium in amniotic fluid 10.62 9.71 4 144621 18 29807835
Aorticopulmonary septal defect 10.62 9.71 4 144621 18 29807835
Squamous cell carcinoma of lung 10.60 9.71 25 144600 1722 29806131
Brain oedema 10.59 9.71 28 144597 12370 29795483
Skin infection 10.55 9.71 58 144567 6086 29801767
Lipase increased 10.49 9.71 16 144609 8660 29799193
Multiple organ dysfunction syndrome 10.49 9.71 230 144395 63257 29744596
Anaemia vitamin B12 deficiency 10.49 9.71 10 144615 300 29807553
Oral herpes 10.48 9.71 46 144579 4409 29803444
Neutropenia neonatal 10.47 9.71 13 144612 528 29807325
BK virus infection 10.43 9.71 4 144621 4360 29803493
Scoliosis 10.41 9.71 24 144601 1628 29806225
Hepatitis C 10.41 9.71 31 144594 13174 29794679
Myocardial infarction 10.40 9.71 498 144127 125127 29682726
Cardiac failure 10.38 9.71 315 144310 83103 29724750
Transverse presentation 10.38 9.71 6 144619 81 29807772
Abscess limb 10.37 9.71 36 144589 3093 29804760
Hyperammonaemia 10.30 9.71 7 144618 5513 29802340
Psychomotor retardation 10.29 9.71 30 144595 2349 29805504
Gross motor delay 10.29 9.71 9 144616 241 29807612
Umbilical cord around neck 10.28 9.71 8 144617 181 29807672
Aplasia pure red cell 10.27 9.71 54 144571 5572 29802281
Body dysmorphic disorder 10.25 9.71 6 144619 83 29807770
Hepatic siderosis 10.24 9.71 8 144617 182 29807671
Vomiting 10.23 9.71 918 143707 218900 29588953
Mesothelioma 10.21 9.71 12 144613 460 29807393
Macrosomia 10.19 9.71 6 144619 84 29807769
Joint instability 10.18 9.71 11 144614 384 29807469
Subdural haematoma 10.17 9.71 52 144573 18920 29788933
Blood pressure diastolic decreased 10.16 9.71 58 144567 6173 29801680
Disseminated intravascular coagulation 10.14 9.71 64 144561 22107 29785746
Autosomal chromosome anomaly 10.12 9.71 4 144621 21 29807832
Ligament laxity 10.12 9.71 4 144621 21 29807832
Pancreatic duct stenosis 10.06 9.71 8 144617 187 29807666
Congenital pulmonary hypertension 10.03 9.71 5 144620 49 29807804
Large intestinal stenosis 10.00 9.71 20 144605 1230 29806623
Ear malformation 9.98 9.71 9 144616 251 29807602
Renal hypertrophy 9.97 9.71 4 144621 22 29807831
Tachycardia foetal 9.94 9.71 10 144615 321 29807532
Contraindicated product administered 9.92 9.71 127 144498 17104 29790749
Neonatal hyponatraemia 9.89 9.71 6 144619 89 29807764
Potentiating drug interaction 9.87 9.71 5 144620 4626 29803227
Fracture 9.85 9.71 56 144569 5950 29801903
Pulmonary tuberculosis 9.83 9.71 48 144577 4809 29803044
Aplasia cutis congenita 9.77 9.71 7 144618 139 29807714
C-reactive protein increased 9.75 9.71 277 144348 43196 29764657
Congenital spinal cord anomaly 9.75 9.71 3 144622 6 29807847
Pyloric stenosis 9.72 9.71 13 144612 569 29807284

Pharmacologic Action:

SourceCodeDescription
ATC B03BB01 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
VITAMIN B12 AND FOLIC ACID
Folic acid and derivatives
ATC V04CX02 VARIOUS
DIAGNOSTIC AGENTS
OTHER DIAGNOSTIC AGENTS
Other diagnostic agents
ATC B03AE01 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in other combinations
ATC B03AE02 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in other combinations
ATC B03BB51 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
VITAMIN B12 AND FOLIC ACID
Folic acid and derivatives
MeSH PA D006397 Hematinics
MeSH PA D006401 Hematologic Agents
MeSH PA D018977 Micronutrients
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
CHEBI has role CHEBI:33284 nutrients
CHEBI has role CHEBI:75769 vitamin b
CHEBI has role CHEBI:75771 mus musculus metabolite
CHEBI has role CHEBI:77746 h. sapiens metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Megaloblastic anemia due to folate deficiency indication 85649008 DOID:14026
Vitamin deficiency indication 85670002
Iron deficiency anemia indication 87522002
Mineral deficiency indication 111379007
Folic acid deficiency indication 190633005
Pregnancy, function indication 289908002
Breastfeeding (mother) indication 413712001
Vitamin Deficiency Prevention indication
Mineral Deficiency Prevention indication
Prevention of Vitamin B12 Deficiency indication
Homocystinuria off-label use 11282001 DOID:9263
Homocystinemia off-label use 52311001
Prevention of Fetal Neural Tube Defects during Pregnancy off-label use
Peptic ulcer contraindication 13200003 DOID:750
Bipolar disorder contraindication 13746004 DOID:3312
Constipation contraindication 14760008 DOID:2089
Operation on stomach contraindication 16453004
Primary hyperoxaluria contraindication 17901006 DOID:2977
Gastroenteritis contraindication 25374005 DOID:2326
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Hemosiderosis contraindication 39011001 DOID:12119
Hypokalemia contraindication 43339004
Gastrectomy contraindication 53442002
Leber's optic atrophy contraindication 58610003 DOID:705
Hemolytic anemia contraindication 61261009 DOID:583
Diarrhea contraindication 62315008
Ulcerative colitis contraindication 64766004 DOID:8577
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Diabetes mellitus contraindication 73211009 DOID:9351
Phototoxicity contraindication 84326006
Atrophic gastritis contraindication 84568007 DOID:8929
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Anemia due to enzyme deficiency contraindication 111577008
Hb SS disease contraindication 127040003 DOID:10923
Osteolysis contraindication 203522001
Hypomania contraindication 231496004
Esophageal dysmotility contraindication 266434009 DOID:9192
Diverticular disease contraindication 397881000
Hemochromatosis contraindication 399187006 DOID:2352
Repeated Blood Transfusions contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.46 acidic
pKa2 5.15 acidic
pKa3 12.96 acidic
pKa4 4.55 Basic
pKa5 4.15 Basic
pKa6 2.28 Basic
pKa7 1.73 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Thymidylate synthase Enzyme Ki 4.40 CHEMBL
Dihydrofolate reductase Unclassified Kd 6.09 CHEMBL

External reference:

IDSource
4017507 VUID
N0000145892 NUI
D00070 KEGG_DRUG
6484-89-5 SECONDARY_CAS_RN
4017507 VANDF
C0304894 UMLSCUI
CHEBI:27470 CHEBI
FOL PDB_CHEM_ID
135398658 PUBCHEM_CID
CHEMBL2107429 ChEMBL_ID
CHEMBL1622 ChEMBL_ID
DB00158 DRUGBANK_ID
D005492 MESH_DESCRIPTOR_UI
4563 IUPHAR_LIGAND_ID
68 INN_ID
9P9W8GGU78 UNII
1300473 RXNORM
264 MMSL
4759 MMSL
d00241 MMSL
001049 NDDF
126224002 SNOMEDCT_US
6247001 SNOMEDCT_US
63718003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ferralet 90 HUMAN PRESCRIPTION DRUG LABEL 5 0178-0089 TABLET, FILM COATED 1 mg ORAL unapproved drug other 17 sections
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 1 mg ORAL Unapproved drug other 12 sections
CitraNatal Harmony 3.0 HUMAN PRESCRIPTION DRUG LABEL 8 0178-0796 CAPSULE, GELATIN COATED 1 mg ORAL unapproved drug other 10 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0798 CAPSULE, GELATIN COATED 1 mg ORAL UNULLPPROVED DRUG OTHER 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0799 CAPSULE, GELATIN COATED 1 mg ORAL Unapproved drug other 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0812 CAPSULE, GELATIN COATED 1 mg ORAL Unapproved drug other 11 sections
CitraNatal Bloom HUMAN PRESCRIPTION DRUG LABEL 6 0178-0813 TABLET, FILM COATED 1.40 mg ORAL unapproved drug other 15 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 1 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 1 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 1 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 1 mg ORAL Unapproved drug other 9 sections
CitraNatal Medley HUMAN PRESCRIPTION DRUG LABEL 8 0178-0896 CAPSULE, GELATIN COATED 1 mg ORAL unapproved drug other 10 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 1 mg ORAL Unapproved drug other 11 sections
Folic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0603-3162 TABLET 1 mg ORAL ANDA 19 sections
Folic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0615-7814 TABLET 1 mg ORAL ANDA 12 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 1 mg ORAL unapproved drug other 7 sections
Vitafol Caplet HUMAN PRESCRIPTION DRUG LABEL 12 0642-0072 CAPSULE 1 mg ORAL UNULLPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 0.40 mg ORAL UNULLPPROVED DRUG OTHER 14 sections
Vitafol OB Caplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 1 mg ORAL Unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 1 mg ORAL UNULLPPROVED DRUG OTHER 13 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 680 ug ORAL UNULLPPROVED DRUG OTHER 13 sections
Vitafol Nano HUMAN PRESCRIPTION DRUG LABEL 7 0642-0094 TABLET, COATED 680 ug ORAL UNULLPPROVED DRUG OTHER 14 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 0.40 mg ORAL UNULLPPROVED DRUG OTHER 13 sections
Strovite Forte Caplet HUMAN PRESCRIPTION DRUG LABEL 19 0642-0204 TABLET, COATED 1 mg ORAL UNULLPPROVED DRUG OTHER 15 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 1 mg ORAL UNULLPPROVED DRUG OTHER 14 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 16 0642-3010 CAPSULE, GELATIN COATED 1 mg ORAL unapproved drug other 7 sections
Vitafol HUMAN PRESCRIPTION DRUG LABEL 4 0642-7468 STRIP 1 mg ORAL Unapproved drug other 13 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 680 mg ORAL UNULLPPROVED DRUG OTHER 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 1000 ug ORAL UNULLPPROVED DRUG OTHER 4 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 1 mg ORAL UNULLPPROVED DRUG OTHER 10 sections