cobamamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4404 13870-90-1

Description:

MoleculeDescription

Synonyms:

  • cobamamide
  • adenosylcobalamin
  • cobalamin coenzyme
  • Vitamin B12 coenzyme
  • Molecular weight: 1579.61
  • Formula: C72H100CoN18O17P
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 608.02
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Ejection fraction abnormal 124.04 19.31 27 3654 2464 90622302
Sensitisation 110.17 19.31 27 3654 4148 90620618
Polycystic ovaries 102.04 19.31 27 3654 5627 90619139
Carpal tunnel syndrome 77.43 19.31 31 3650 23897 90600869
Rhinitis allergic 73.11 19.31 27 3654 16758 90608008
Ejection fraction 72.02 19.31 18 3663 2993 90621773
Blood test abnormal 70.77 19.31 28 3653 20924 90603842
Nephrectomy 68.80 19.31 16 3665 1965 90622801
Nephropathy 59.95 19.31 20 3661 9215 90615551
Sleep disorder due to a general medical condition 56.04 19.31 30 3651 44708 90580058
Renal disorder 54.89 19.31 28 3653 37831 90586935
Sleep apnoea syndrome 53.47 19.31 26 3655 31721 90593045
Fibromyalgia 44.38 19.31 48 3633 206221 90418545
Hypothyroidism 43.46 19.31 27 3654 53100 90571666
Cardiac disorder 41.78 19.31 27 3654 56845 90567921
Burning sensation 39.09 19.31 27 3654 63425 90561341
Full blood count abnormal 33.52 19.31 20 3661 36577 90588189
Gastrooesophageal reflux disease 32.80 19.31 37 3644 166300 90458466
Sleep disorder due to general medical condition, insomnia type 31.31 19.31 32 3649 128662 90496104
Dementia 27.09 19.31 15 3666 23846 90600920
Wheezing 25.17 19.31 39 3642 238041 90386725
Cardiac amyloidosis 23.81 19.31 6 3675 1030 90623736
Physical examination of joints abnormal 23.54 19.31 4 3677 97 90624669
Blood albumin abnormal 23.19 19.31 6 3675 1143 90623623
Asthma 21.96 19.31 37 3644 242123 90382643
Medication overuse headache 21.60 19.31 6 3675 1495 90623271
Loss of personal independence in daily activities 21.41 19.31 27 3654 136078 90488688
Hospitalisation 21.09 19.31 26 3655 128074 90496692
Intentional product use issue 20.81 19.31 34 3647 216858 90407908
Blood calcium abnormal 19.97 19.31 6 3675 1971 90622795
Adverse event 19.60 19.31 24 3657 117394 90507372

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Ultrasound antenatal screen 92.05 57.77 15 895 549 42619876
Drug-induced liver injury 90.44 57.77 33 877 38240 42582185
Needle fatigue 86.99 57.77 16 894 1197 42619228
Trisomy 18 85.64 57.77 15 895 850 42619575
Hydrops foetalis 84.96 57.77 15 895 890 42619535
Gait spastic 84.59 57.77 16 894 1393 42619032
Cleft lip and palate 84.52 57.77 15 895 917 42619508
Relapsing-remitting multiple sclerosis 83.65 57.77 16 894 1479 42618946
Hepatitis 81.42 57.77 28 882 27272 42593153
Hypertonic bladder 76.22 57.77 16 894 2365 42618060
Monoparesis 72.75 57.77 16 894 2944 42617481
Muscle spasticity 59.47 57.77 16 894 6806 42613619

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Ejection fraction abnormal 114.59 21.29 27 4566 3433 110581273
Sensitisation 109.70 21.29 27 4566 4124 110580582
Polycystic ovaries 105.83 21.29 27 4566 4769 110579937
Hydrops foetalis 89.51 21.29 17 4576 764 110583942
Trisomy 18 86.94 21.29 16 4577 605 110584101
Ultrasound antenatal screen 84.89 21.29 16 4577 690 110584016
Cleft lip and palate 84.31 21.29 16 4577 716 110583990
Needle fatigue 75.59 21.29 16 4577 1248 110583458
Gait spastic 72.35 21.29 16 4577 1533 110583173
Ejection fraction 71.94 21.29 18 4575 2937 110581769
Rhinitis allergic 70.78 21.29 27 4566 17895 110566811
Relapsing-remitting multiple sclerosis 67.64 21.29 16 4577 2066 110582640
Blood test abnormal 64.98 21.29 29 4564 28525 110556181
Carpal tunnel syndrome 64.70 21.29 27 4566 22583 110562123
Nephrectomy 63.87 21.29 16 4577 2624 110582082
Monoparesis 55.23 21.29 16 4577 4537 110580169
Sleep disorder due to a general medical condition 53.77 21.29 31 4562 52081 110532625
Hypertonic bladder 52.82 21.29 16 4577 5286 110579420
Nephropathy 52.14 21.29 20 4573 13447 110571259
Renal disorder 49.90 21.29 29 4564 49450 110535256
Muscle spasticity 49.87 21.29 26 4567 35889 110548817
Sleep apnoea syndrome 49.73 21.29 27 4566 40420 110544286
Fibromyalgia 43.52 21.29 44 4549 170865 110413841
Drug-induced liver injury 40.26 21.29 36 4557 120031 110464675
Central nervous system lesion 39.27 21.29 17 4576 15536 110569170
Burning sensation 38.68 21.29 28 4565 69184 110515522
Hypothyroidism 37.38 21.29 28 4565 72871 110511835
Sleep disorder due to general medical condition, insomnia type 36.05 21.29 32 4561 105611 110479095
Foetal exposure during pregnancy 35.83 21.29 13 4580 7492 110577214
Nocturia 34.67 21.29 16 4577 16974 110567732
Pollakiuria 34.52 21.29 22 4571 44173 110540533
Cardiac disorder 34.08 21.29 27 4566 76253 110508453
Erectile dysfunction 33.33 21.29 16 4577 18540 110566166
Gastrooesophageal reflux disease 33.01 21.29 39 4554 179937 110404769
Micturition urgency 32.71 21.29 16 4577 19304 110565402
Hepatitis 32.17 21.29 28 4565 90026 110494680
Intentional product use issue 30.33 21.29 44 4549 247862 110336844
Full blood count abnormal 29.78 21.29 22 4571 56030 110528676
Ataxia 26.06 21.29 16 4577 30092 110554614
Asthma 25.76 21.29 41 4552 250250 110334456
Movement disorder 25.68 21.29 17 4576 36387 110548319
Wheezing 25.16 21.29 41 4552 255189 110329517
Blood albumin abnormal 24.92 21.29 6 4587 835 110583871
Dementia 22.84 21.29 15 4578 31658 110553048
Cardiac amyloidosis 21.71 21.29 7 4586 2830 110581876

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B03BA04 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
VITAMIN B12 AND FOLIC ACID
Vitamin B12 (cyanocobalamin and analogues)
CHEBI has role CHEBI:23354 coenzyme
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:26348 prosthetic group
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:76971 <em>Escherichia coli</em> metabolite
CHEBI has role CHEBI:77746 human metabolite

Related Drugs by ATC class:

B03BA Vitamin B12 (cyanocobalamin and analogues) 3 drugs
cyanocobalaminhydroxocobalaminmecobalamin

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Prevention of Vitamin B12 Deficiency indication
Hypokalemia contraindication 43339004
Gastrectomy contraindication 53442002
Leber's optic atrophy contraindication 58610003 DOID:705
Atrophic gastritis contraindication 84568007 DOID:8929




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D00042 KEGG_DRUG
C0056039 UMLSCUI
CHEBI:18408 CHEBI
B1Z PDB_CHEM_ID
CHEMBL3833359 ChEMBL_ID
DB11191 DRUGBANK_ID
C000913 MESH_SUPPLEMENTAL_RECORD_UI
1915 INN_ID
F0R1QK73KB UNII
131635025 PUBCHEM_CID
21373 RXNORM
NOCODE MMSL
004345 NDDF
259509008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
PaxLyte HUMAN PRESCRIPTION DRUG LABEL 18 64661-217 CAPSULE 50 ug ORAL unapproved drug other 9 sections
EnBrace HR HUMAN PRESCRIPTION DRUG LABEL 16 64661-650 CAPSULE, DELAYED RELEASE PELLETS 50 ug ORAL UNAPPROVED DRUG OTHER 11 sections
Biopar delta-FORTE HUMAN PRESCRIPTION DRUG LABEL 6 64661-793 CAPSULE 50 ug ORAL unapproved drug other 11 sections