ascorbic acid ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4072 50-81-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • vitamin c
  • L-Ascorbic acid
  • ascorbic acid
  • ascorbic acid (vit C)
  • sodium ascorbate
  • calcium ascorbate
  • ascorbic acid, monosodium salt
A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant. NIH COVID-19 Treatment Guidelines Panel states that there are insufficient data to recommend either for or against use of ascorbic acid for the treatment of COVID-19 in critically or noncritically ill patients.
  • Molecular weight: 176.12
  • Formula: C6H8O6
  • CLOGP: -1.76
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 4
  • TPSA: 107.22
  • ALOGS: 0.14
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.20 g O
0.20 g P
0.25 g V

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 0 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 333 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 25 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 567.77 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.35 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.05 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.26 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 11.40 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1199.82 10.24 3086 460587 117080 50024371
Systemic lupus erythematosus 1096.41 10.24 3300 460373 137322 50004129
Glossodynia 959.60 10.24 2774 460899 112795 50028656
Completed suicide 920.82 10.24 77 463596 131812 50009639
Rheumatoid arthritis 876.89 10.24 3927 459746 198623 49942828
Hand deformity 746.29 10.24 2315 461358 97884 50043567
Toxicity to various agents 723.08 10.24 535 463138 211964 49929487
Arthropathy 708.26 10.24 3095 460578 154811 49986640
Abdominal discomfort 698.60 10.24 4058 459615 227583 49913868
Alopecia 682.24 10.24 4204 459469 240843 49900608
Maternal exposure during pregnancy 626.12 10.24 3010 460663 156768 49984683
Wound 602.31 10.24 2234 461439 103560 50037891
Pain 598.00 10.24 7996 455677 570907 49570544
Joint swelling 517.90 10.24 3932 459741 241354 49900097
Death 472.22 10.24 1473 462200 323906 49817545
Infusion related reaction 468.09 10.24 2904 460769 166653 49974798
Contraindicated product administered 459.74 10.24 2627 461046 146331 49995120
Pericarditis 450.48 10.24 1665 462008 77024 50064427
Drug interaction 445.70 10.24 713 462960 198908 49942543
Anti-cyclic citrullinated peptide antibody positive 441.07 10.24 1537 462136 69050 50072401
Synovitis 440.61 10.24 2271 461402 121594 50019857
Discomfort 421.45 10.24 2038 461635 106342 50035109
Swelling 404.16 10.24 3185 460488 197687 49943764
Drug abuse 398.71 10.24 42 463631 59804 50081647
Intentional overdose 362.21 10.24 67 463606 62437 50079014
Hepatic enzyme increased 268.17 10.24 2164 461509 135216 50006235
Rheumatoid factor positive 264.57 10.24 1030 462643 48829 50092622
Product use issue 264.42 10.24 2303 461370 147172 49994279
Arthralgia 256.17 10.24 5530 458143 433172 49708279
Duodenal ulcer perforation 250.82 10.24 953 462720 44658 50096793
Helicobacter infection 241.51 10.24 999 462674 48703 50092748
Suicide attempt 237.98 10.24 88 463585 51644 50089807
Cardiac arrest 228.91 10.24 257 463416 83394 50058057
Febrile neutropenia 226.18 10.24 340 463333 97327 50044124
Overdose 225.36 10.24 353 463320 99374 50042077
Acute kidney injury 218.80 10.24 1211 462462 226847 49914604
Hip arthroplasty 190.29 10.24 663 463010 29766 50111685
Nasopharyngitis 183.01 10.24 2629 461044 190298 49951153
Knee arthroplasty 175.30 10.24 722 462951 35124 50106327
Exposure during pregnancy 172.77 10.24 1782 461891 119233 50022218
Neutropenia 160.34 10.24 753 462920 147212 49994239
Fatigue 158.00 10.24 7955 455718 699646 49441805
Lower respiratory tract infection 157 10.24 1445 462228 93756 50047695
Sinusitis 154.54 10.24 2306 461367 168252 49973199
Cardiac failure 154.48 10.24 288 463385 75752 50065699
Musculoskeletal stiffness 150.61 10.24 1820 461853 126661 50014790
Device expulsion 150.54 10.24 39 463634 28783 50112668
Malignant neoplasm progression 150.22 10.24 245 463428 67879 50073572
Electrocardiogram QT prolonged 150.20 10.24 152 463521 51734 50089717
Psoriatic arthropathy 147.78 10.24 834 462839 46198 50095253
Drug hypersensitivity 143.26 10.24 1539 462134 249471 49891980
Lactic acidosis 143.19 10.24 63 463610 33292 50108159
Therapeutic product effect decreased 139.04 10.24 1879 461794 134171 50007280
Depressed level of consciousness 138.44 10.24 163 463510 51790 50089661
Hypersensitivity 138.07 10.24 2752 460921 212409 49929042
Hyponatraemia 136.36 10.24 439 463234 95700 50045751
Drug reaction with eosinophilia and systemic symptoms 126.33 10.24 51 463622 28373 50113078
Disease progression 124.28 10.24 455 463218 95411 50046040
Bradycardia 123.93 10.24 252 463421 64174 50077277
Respiratory arrest 120.66 10.24 62 463611 29947 50111504
Red blood cell sedimentation rate abnormal 119.97 10.24 376 463297 15967 50125484
Impaired healing 119.48 10.24 1068 462605 68718 50072733
Drug intolerance 118.21 10.24 2733 460940 216371 49925080
Sopor 117.99 10.24 20 463653 19859 50121592
Nausea 115.30 10.24 5289 458384 700109 49441342
Renal failure 114.10 10.24 545 463128 106088 50035363
Treatment failure 111.70 10.24 1827 461846 135810 50005641
Intentional self-injury 110.25 10.24 37 463636 23075 50118376
Rhabdomyolysis 109.94 10.24 117 463556 38910 50102541
Hypotension 109.48 10.24 1509 462164 233960 49907491
Cardio-respiratory arrest 106.91 10.24 207 463466 53685 50087766
Sickle cell anaemia with crisis 106.65 10.24 167 463506 4376 50137075
Rash 105.51 10.24 4958 458715 432513 49708938
Immunodeficiency 103.24 10.24 335 463338 14493 50126958
Dyspnoea 103.12 10.24 4040 459633 543568 49597883
Peripheral swelling 102.32 10.24 2540 461133 203396 49938055
Agitation 98.31 10.24 214 463459 53170 50088281
C-reactive protein abnormal 97.39 10.24 508 463165 27301 50114150
Rheumatic fever 96.49 10.24 357 463316 16510 50124941
Psoriasis 95.53 10.24 1010 462663 67990 50073461
Swollen joint count increased 94.66 10.24 326 463347 14547 50126904
Hypoglycaemia 91.25 10.24 224 463449 53357 50088094
Metabolic acidosis 90.96 10.24 134 463539 38691 50102760
Hepatic failure 89.58 10.24 98 463575 32185 50109266
Tachycardia 88.95 10.24 542 463131 99221 50042230
Renal impairment 87.32 10.24 376 463297 75285 50066166
Drug dependence 86.92 10.24 36 463637 19723 50121728
Tremor 86.65 10.24 656 463017 114247 50027204
Osteoarthritis 84.80 10.24 982 462691 67624 50073827
Serotonin syndrome 82.87 10.24 63 463610 24650 50116801
Muscle spasticity 81.56 10.24 343 463330 16841 50124610
Thrombocytopenia 80.93 10.24 763 462910 126910 50014541
Syncope 80.56 10.24 582 463091 102420 50039031
Pregnancy 80.39 10.24 505 463168 29072 50112379
Arthritis 79.80 10.24 1176 462497 85545 50055906
Drug resistance 79.73 10.24 37 463636 18952 50122499
Night sweats 79.60 10.24 554 463119 33020 50108431
Anaemia 79.52 10.24 1735 461938 250721 49890730
Ear pain 78.18 10.24 485 463188 27798 50113653
Somnolence 77.91 10.24 977 462696 154008 49987443
Temperature regulation disorder 77.36 10.24 139 463534 4088 50137363
Multiple organ dysfunction syndrome 75.50 10.24 224 463449 50113 50091338
Body temperature increased 74.21 10.24 517 463156 30824 50110627
Muscle injury 73.59 10.24 587 463086 36524 50104927
Respiratory failure 72.87 10.24 512 463161 90669 50050782
Hepatic function abnormal 72.53 10.24 117 463556 32564 50108887
Hepatocellular injury 71.73 10.24 79 463594 25868 50115583
Cholestasis 71.71 10.24 76 463597 25325 50116126
Folliculitis 70.59 10.24 607 463066 38618 50102833
Sedation 70.39 10.24 107 463566 30503 50110948
Sleep disorder due to general medical condition, insomnia type 69.96 10.24 511 463162 30936 50110515
Femur fracture 68.60 10.24 582 463091 36882 50104569
Cytomegalovirus infection 68.02 10.24 40 463633 17922 50123529
Seizure 67.81 10.24 721 462952 117153 50024298
Anxiety 67.62 10.24 1182 462491 176424 49965027
Hypoxia 66.65 10.24 242 463431 50881 50090570
Dizziness 66.60 10.24 2548 461125 343821 49797630
Drug withdrawal syndrome 66.48 10.24 79 463594 25002 50116449
Encephalopathy 66.41 10.24 130 463543 33581 50107870
Live birth 65.43 10.24 311 463362 16097 50125354
Product quality issue 64.32 10.24 115 463558 30743 50110708
No adverse event 64.00 10.24 132 463541 33446 50108005
Anaphylactic reaction 63.99 10.24 266 463407 53789 50087662
Altered state of consciousness 63.61 10.24 64 463609 21846 50119605
Abortion spontaneous 63.32 10.24 623 463050 41149 50100302
Hypokalaemia 63.23 10.24 509 463164 87483 50053968
Poisoning 62.69 10.24 18 463655 12411 50129040
Intentional product misuse 62.41 10.24 219 463454 46515 50094936
Blood pressure fluctuation 62.20 10.24 550 463123 35273 50106178
Bursitis 62.07 10.24 381 463292 21754 50119697
Hyperkalaemia 61.14 10.24 230 463443 47859 50093592
Blister 60.98 10.24 1111 462562 84307 50057144
Loss of consciousness 60.54 10.24 637 463036 103716 50037735
Leukopenia 60.11 10.24 367 463306 67161 50074290
Hyperglycaemia 59.04 10.24 156 463517 36249 50105202
Coma 58.91 10.24 294 463379 56585 50084866
Vomiting 57.72 10.24 3546 460127 457212 49684239
Contusion 57.53 10.24 1390 462283 110793 50030658
Mydriasis 56.23 10.24 14 463659 10613 50130838
Extrapyramidal disorder 55.86 10.24 19 463654 11751 50129700
Palmar-plantar erythrodysaesthesia syndrome 55.77 10.24 61 463612 20037 50121414
Injection site erythema 55.73 10.24 981 462692 73955 50067496
Osteoporosis 55.27 10.24 642 463031 44237 50097214
Suicidal ideation 55.25 10.24 290 463383 55095 50086356
Metastases to bone 54.05 10.24 51 463622 17944 50123507
Diarrhoea 53.87 10.24 4652 459021 583824 49557627
Acute hepatic failure 53.81 10.24 39 463634 15638 50125813
Joint effusion 53.53 10.24 249 463424 12772 50128679
Diabetic ketoacidosis 53.27 10.24 51 463622 17821 50123630
Ejection fraction decreased 52.74 10.24 55 463618 18465 50122986
Irritable bowel syndrome 52.69 10.24 711 462962 50730 50090721
Hallucination 52.52 10.24 234 463439 46423 50095028
Disorientation 52.42 10.24 159 463514 35325 50106126
Product use in unapproved indication 52.04 10.24 747 462926 115072 50026379
Gamma-glutamyltransferase increased 51.89 10.24 122 463551 29501 50111950
Disability assessment scale score increased 51.67 10.24 84 463589 2274 50139177
Hypothermia 51.09 10.24 23 463650 11993 50129458
Delirium 50.97 10.24 179 463494 38013 50103438
Juvenile idiopathic arthritis 50.57 10.24 93 463580 2786 50138665
Injection site pruritus 50.17 10.24 579 463094 39832 50101619
Torsade de pointes 49.78 10.24 23 463650 11812 50129639
Shock 49.62 10.24 70 463603 20580 50120871
Fibromyalgia 48.70 10.24 628 463045 44350 50097101
Myalgia 48.70 10.24 823 462850 123496 50017955
Angioedema 48.68 10.24 179 463494 37497 50103954
Blood bilirubin increased 48.45 10.24 142 463531 31896 50109555
Ill-defined disorder 48.25 10.24 736 462937 53918 50087533
Food allergy 48.03 10.24 174 463499 7963 50133488
Cardiac failure congestive 47.76 10.24 518 463155 83864 50057587
Basal cell carcinoma 47.16 10.24 371 463302 22985 50118466
Abnormal behaviour 46.87 10.24 67 463606 19591 50121860
Metastases to liver 46.49 10.24 70 463603 20034 50121417
Disseminated intravascular coagulation 46.46 10.24 53 463620 17082 50124369
Neuropathy peripheral 46.35 10.24 616 463057 96141 50045310
Weight increased 45.69 10.24 2275 461398 199616 49941835
Drug level increased 45.62 10.24 66 463607 19202 50122249
Multiple sclerosis relapse 44.53 10.24 222 463451 42742 50098709
Blood creatine phosphokinase increased 44.28 10.24 111 463562 26256 50115195
Injection site reaction 44.26 10.24 674 462999 49358 50092093
Joint laxity 44.07 10.24 79 463594 2319 50139132
Osteonecrosis of jaw 43.71 10.24 152 463521 32374 50109077
Dehydration 43.36 10.24 1064 462609 151385 49990066
Neuroleptic malignant syndrome 43.27 10.24 24 463649 11106 50130345
Foot deformity 43.21 10.24 313 463360 18897 50122554
Blood cholesterol increased 42.91 10.24 728 462945 54487 50086964
Neoplasm progression 42.82 10.24 131 463542 29026 50112425
Coeliac disease 42.50 10.24 175 463498 8510 50132941
Accidental overdose 42.34 10.24 71 463602 19462 50121989
Inappropriate antidiuretic hormone secretion 42.18 10.24 35 463638 13108 50128343
Carpal tunnel syndrome 41.97 10.24 282 463391 16611 50124840
Unresponsive to stimuli 41.83 10.24 142 463531 30467 50110984
Grip strength decreased 41.46 10.24 220 463453 11901 50129550
Akathisia 41.35 10.24 12 463661 8217 50133234
Caesarean section 41.24 10.24 265 463408 15374 50126077
Anaphylactic shock 41.21 10.24 76 463597 20079 50121372
Pulmonary arterial hypertension 41.21 10.24 77 463596 20242 50121209
Loss of personal independence in daily activities 40.89 10.24 884 462789 69166 50072285
Mental status changes 40.78 10.24 182 463491 36090 50105361
Blood pressure diastolic abnormal 40.70 10.24 182 463491 9179 50132272
Injection site swelling 40.60 10.24 572 463101 41201 50100250
Multiple fractures 38.71 10.24 141 463532 6470 50134981
Respiratory depression 38.53 10.24 32 463641 11978 50129473
Posterior reversible encephalopathy syndrome 38.52 10.24 48 463625 14880 50126571
Myocardial infarction 38.32 10.24 579 463094 88448 50053003
Dysarthria 37.78 10.24 195 463478 37208 50104243
Pyrexia 37.17 10.24 2989 460684 377214 49764237
Product administration error 37.06 10.24 78 463595 19621 50121830
Transplant rejection 36.95 10.24 21 463652 9588 50131863
Schizophrenia 36.78 10.24 11 463662 7386 50134065
Blood glucose increased 36.41 10.24 448 463225 70876 50070575
Confusional state 36.25 10.24 1365 462308 184563 49956888
Condition aggravated 36.17 10.24 3176 460497 293882 49847569
Blood alkaline phosphatase increased 36.03 10.24 199 463474 37327 50104124
Psychotic disorder 35.72 10.24 93 463580 21719 50119732
Ventricular tachycardia 35.71 10.24 56 463617 15765 50125686
Maternal drugs affecting foetus 35.61 10.24 115 463558 4962 50136489
Neutrophil count decreased 35.51 10.24 261 463412 45765 50095686
Diabetes mellitus inadequate control 35.27 10.24 41 463632 13104 50128347
Eosinophilia 34.97 10.24 74 463599 18578 50122873
Obstructive airways disorder 34.76 10.24 56 463617 15596 50125855
Cerebral haemorrhage 34.63 10.24 129 463544 26923 50114528
Polyneuropathy 34.57 10.24 36 463637 12095 50129356
Parkinsonism 34.50 10.24 19 463654 8828 50132623
Disturbance in attention 34.15 10.24 158 463515 31028 50110423
Aggression 33.85 10.24 91 463582 21025 50120426
Device dislocation 33.68 10.24 94 463579 21452 50119999
Aspartate aminotransferase increased 33.66 10.24 507 463166 77491 50063960
Dyskinesia 33.66 10.24 136 463537 27725 50113726
Blood pressure systolic abnormal 33.64 10.24 150 463523 7556 50133895
Neck deformity 33.62 10.24 63 463610 1915 50139536
Restlessness 33.58 10.24 118 463555 25055 50116396
Nightmare 33.47 10.24 60 463613 16026 50125425
Ascites 33.44 10.24 192 463481 35669 50105782
Pulmonary embolism 33.40 10.24 694 462979 101010 50040441
Blood pressure decreased 33.35 10.24 339 463334 55570 50085881
Alanine aminotransferase increased 33.28 10.24 589 463084 87770 50053681
Gestational diabetes 33.11 10.24 146 463527 7319 50134132
Wrong technique in product usage process 32.94 10.24 337 463336 55173 50086278
Accidental exposure to product 32.86 10.24 105 463568 22952 50118499
Red blood cell sedimentation rate increased 32.81 10.24 413 463260 29003 50112448
Mania 32.71 10.24 31 463642 10885 50130566
Thrombotic microangiopathy 32.69 10.24 20 463653 8771 50132680
Blood creatinine increased 32.54 10.24 496 463177 75664 50065787
Toxic skin eruption 32.50 10.24 33 463640 11218 50130233
Neurotoxicity 32.49 10.24 53 463620 14687 50126764
Pleural effusion 32.28 10.24 538 463135 80916 50060535
Speech disorder 32.26 10.24 192 463481 35356 50106095
Cognitive disorder 32.25 10.24 254 463419 43869 50097582
Sepsis 32.23 10.24 949 462724 131976 50009475
Device difficult to use 32.13 10.24 26 463647 9860 50131591
Febrile bone marrow aplasia 32.09 10.24 9 463664 6302 50135149
Dysphagia 32.05 10.24 508 463165 77010 50064441
Drug ineffective for unapproved indication 31.69 10.24 95 463578 21186 50120265
Brain oedema 31.69 10.24 40 463633 12330 50129121
Face oedema 31.62 10.24 73 463600 17766 50123685
Sensitisation 31.52 10.24 54 463619 1528 50139923
Melaena 31.29 10.24 133 463540 26731 50114720
Hypomagnesaemia 31.25 10.24 108 463565 23048 50118403
Pain in jaw 31.07 10.24 215 463458 38213 50103238
Acute generalised exanthematous pustulosis 30.98 10.24 22 463651 8916 50132535
Ischaemic stroke 30.98 10.24 62 463611 15886 50125565
Agranulocytosis 30.92 10.24 97 463576 21324 50120127
Haematotoxicity 30.72 10.24 17 463656 7878 50133573
Haemorrhage 30.66 10.24 327 463346 53114 50088337
Chest discomfort 30.65 10.24 632 463041 92090 50049361
Premature labour 30.59 10.24 195 463478 11281 50130170
Arrhythmia 30.57 10.24 178 463495 32954 50108497
Ventricular fibrillation 30.47 10.24 31 463642 10528 50130923
Respiratory distress 30.20 10.24 160 463513 30329 50111122
Jaundice 30.08 10.24 132 463541 26297 50115154
Injection site pain 30.04 10.24 1274 462399 109750 50031701
Pulmonary oedema 29.91 10.24 295 463378 48643 50092808
Bone marrow failure 29.63 10.24 141 463532 27483 50113968
Dyspnoea exertional 29.59 10.24 313 463360 50920 50090531
Metastases to central nervous system 29.40 10.24 36 463637 11246 50130205
Limb deformity 29.35 10.24 88 463585 3646 50137805
Stress cardiomyopathy 29.25 10.24 18 463655 7869 50133582
Myoclonus 29.20 10.24 55 463618 14415 50127036
Cardiogenic shock 29.15 10.24 62 463611 15537 50125914
Pancreatitis acute 28.91 10.24 116 463557 23696 50117755
Pre-eclampsia 28.89 10.24 148 463525 7896 50133555
Rash maculo-papular 28.56 10.24 136 463537 26505 50114946
Intentional product use issue 28.42 10.24 914 462759 76004 50065447
Bone erosion 28.38 10.24 194 463479 11493 50129958
Chronic kidney disease 28.12 10.24 231 463442 39540 50101911
Acute myeloid leukaemia 28.10 10.24 60 463613 15014 50126437
Hepatotoxicity 28.03 10.24 141 463532 27085 50114366
Bronchospasm 27.79 10.24 59 463614 14795 50126656
Device use error 27.74 10.24 7 463666 5259 50136192
Graft versus host disease 27.50 10.24 11 463662 6155 50135296
Hyperhidrosis 27.39 10.24 617 463056 88809 50052642
Platelet count decreased 27.28 10.24 708 462965 100018 50041433
Asphyxia 27.11 10.24 8 463665 5419 50136032
Decreased appetite 27.07 10.24 1535 462138 199388 49942063
Pulmonary hypertension 26.99 10.24 187 463486 33230 50108221
Type 2 diabetes mellitus 26.99 10.24 454 463219 33921 50107530
Ventricular septal defect 26.97 10.24 90 463583 3951 50137500
Disease recurrence 26.87 10.24 94 463579 19987 50121464
Metastases to lung 26.83 10.24 37 463636 10983 50130468
Haemorrhage intracranial 26.80 10.24 45 463628 12329 50129122
Coagulopathy 26.79 10.24 80 463593 17864 50123587
Maternal exposure before pregnancy 26.78 10.24 112 463561 5485 50135966
Foetal exposure during pregnancy 26.73 10.24 375 463298 26984 50114467
Upper respiratory tract infection 26.72 10.24 792 462881 65106 50076345
Tuberculosis 26.68 10.24 171 463502 9912 50131539
Blood pressure systolic increased 26.67 10.24 465 463208 34984 50106467
Ejection fraction 26.64 10.24 43 463630 1157 50140294
Polyarthritis 26.51 10.24 143 463530 7784 50133667
Pain in extremity 26.39 10.24 2871 460802 269994 49871457
Joint stiffness 26.30 10.24 407 463266 29901 50111550
Atrioventricular block complete 26.30 10.24 17 463656 7238 50134213
Intramedullary rod insertion 26.01 10.24 57 463616 1943 50139508
Hospitalisation 25.86 10.24 452 463221 67485 50073966
Acute graft versus host disease 25.79 10.24 3 463670 3955 50137496
Stevens-Johnson syndrome 25.76 10.24 107 463566 21645 50119806
Chest pain 25.74 10.24 1341 462332 175541 49965910
Off label use 25.70 10.24 3885 459788 470541 49670910
Heart rate decreased 25.43 10.24 473 463200 36024 50105427
Miosis 25.42 10.24 13 463660 6297 50135154
Palpitations 25.40 10.24 665 463008 93841 50047610
Cytokine release syndrome 25.31 10.24 25 463648 8609 50132842
Status epilepticus 25.29 10.24 53 463620 13353 50128098
Blood pressure diastolic decreased 25.29 10.24 250 463423 16531 50124920
Respiratory disorder 25.26 10.24 414 463259 30773 50110678
Dystonia 25.25 10.24 44 463629 11882 50129569
International normalised ratio increased 25.18 10.24 263 463410 42889 50098562
Withdrawal syndrome 25.14 10.24 80 463593 17510 50123941
Cerebral infarction 25.13 10.24 107 463566 21497 50119954
Enthesopathy 24.90 10.24 131 463542 7062 50134389
Injection site rash 24.87 10.24 242 463431 15935 50125516
Oral herpes 24.86 10.24 295 463378 20430 50121021
Vertigo 24.80 10.24 330 463343 51502 50089949
Premature rupture of membranes 24.59 10.24 95 463578 4485 50136966
Genital haemorrhage 24.38 10.24 15 463658 6559 50134892
Immune reconstitution inflammatory syndrome 24.34 10.24 10 463663 5506 50135945
Bradyphrenia 24.30 10.24 13 463660 6139 50135312
Orthostatic hypotension 24.30 10.24 164 463509 29317 50112134
Vision blurred 24.27 10.24 542 463131 78105 50063346
Infection 24.19 10.24 1869 461804 171085 49970366
Haemophagocytic lymphohistiocytosis 24.18 10.24 26 463647 8607 50132844
Tenosynovitis stenosans 24.10 10.24 59 463614 2165 50139286
Drug ineffective 24.06 10.24 8111 455562 811222 49330229
Pemphigoid 24.05 10.24 12 463661 5895 50135556
Second primary malignancy 23.99 10.24 17 463656 6897 50134554
Tenderness 23.94 10.24 268 463405 18297 50123154
Muscle rigidity 23.93 10.24 33 463640 9796 50131655
Polycystic ovaries 23.90 10.24 63 463610 2421 50139030
Emotional distress 23.85 10.24 159 463514 28504 50112947
Synovial cyst 23.81 10.24 142 463531 8024 50133427
Ear infection 23.80 10.24 352 463321 25618 50115833
Labelled drug-drug interaction medication error 23.73 10.24 37 463636 10440 50131011
Depression 23.71 10.24 1256 462417 164167 49977284
Hypomania 23.71 10.24 6 463667 4499 50136952
Rotator cuff repair 23.57 10.24 50 463623 1666 50139785
Haematoma 23.54 10.24 173 463500 30337 50111114
Constipation 23.53 10.24 1427 462246 184281 49957170
Hemiparesis 23.50 10.24 99 463574 19949 50121502
Rheumatoid nodule 23.39 10.24 198 463475 12537 50128914
Proteinuria 23.36 10.24 76 463597 16521 50124930
Joint destruction 23.34 10.24 84 463589 3832 50137619
Small for dates baby 23.33 10.24 78 463595 3427 50138024
Tachypnoea 23.23 10.24 63 463610 14514 50126937
Paradoxical drug reaction 23.19 10.24 3 463670 3644 50137807
Disability 23.14 10.24 198 463475 12577 50128874
Nodule 23.10 10.24 248 463425 16755 50124696
Injection site bruising 23.08 10.24 469 463204 36299 50105152
Cerebrovascular accident 22.93 10.24 676 462997 94004 50047447
Smear cervix abnormal 22.89 10.24 66 463607 2675 50138776
Latent tuberculosis 22.73 10.24 58 463615 2185 50139266
Blood pressure diastolic increased 22.72 10.24 131 463542 7312 50134139
Substance abuse 22.68 10.24 5 463668 4119 50137332
Tardive dyskinesia 22.61 10.24 20 463653 7259 50134192
Arthritis infective 22.53 10.24 106 463567 5463 50135988
Irritability 22.51 10.24 160 463513 28266 50113185
Anuria 22.46 10.24 43 463630 11201 50130250
Hallucination, auditory 22.34 10.24 40 463633 10688 50130763
Tumour lysis syndrome 22.33 10.24 21 463652 7400 50134051
Drug-induced liver injury 22.31 10.24 158 463515 27937 50113514
Hypocalcaemia 22.19 10.24 149 463524 26667 50114784
Gastrointestinal haemorrhage 22.14 10.24 507 463166 72814 50068637
Laryngitis 22.10 10.24 174 463499 10782 50130669
Hepatic cytolysis 22.04 10.24 25 463648 8078 50133373
Pancreatitis 21.99 10.24 267 463406 42347 50099104
Joint range of motion decreased 21.98 10.24 263 463410 18249 50123202
Psychomotor hyperactivity 21.88 10.24 32 463641 9269 50132182
Tubulointerstitial nephritis 21.87 10.24 69 463604 15142 50126309
Localised infection 21.65 10.24 341 463332 25144 50116307
Oliguria 21.64 10.24 26 463647 8190 50133261
Atrial fibrillation 21.62 10.24 739 462934 101006 50040445
Abdominal pain 21.54 10.24 1867 461806 234361 49907090
Toxic epidermal necrolysis 21.45 10.24 109 463564 20883 50120568
Urinary retention 21.43 10.24 146 463527 26044 50115407
Erythema multiforme 21.42 10.24 31 463642 9019 50132432
Oropharyngeal pain 21.32 10.24 894 462779 76907 50064544
Herpes zoster 21.15 10.24 821 462852 69965 50071486
Wheelchair user 21.12 10.24 96 463577 4876 50136575
Bronchopulmonary aspergillosis 21.11 10.24 23 463650 7569 50133882
Myocarditis 21.09 10.24 25 463648 7922 50133529
Bone pain 21.06 10.24 305 463368 46924 50094527
Forced expiratory volume decreased 21.02 10.24 7 463666 4387 50137064
Deafness transitory 20.92 10.24 49 463624 1747 50139704
Neck mass 20.80 10.24 73 463600 3288 50138163
Cardiac failure acute 20.80 10.24 27 463646 8223 50133228
Complication of device insertion 20.77 10.24 15 463658 6026 50135425
Asthenia 20.74 10.24 2583 461090 316459 49824992
Hypertransaminasaemia 20.64 10.24 4 463669 3607 50137844
Sinus tachycardia 20.63 10.24 113 463560 21241 50120210
Hallucination, visual 20.63 10.24 80 463593 16502 50124949
Inflammation 20.43 10.24 674 462999 56238 50085213
Shock haemorrhagic 20.33 10.24 28 463645 8316 50133135
Premature delivery 20.24 10.24 317 463356 23346 50118105
Fracture delayed union 20.17 10.24 56 463617 2220 50139231
Myopathy 20.01 10.24 33 463640 9106 50132345
Spinal stenosis 20.00 10.24 201 463472 13349 50128102
Dysmorphism 19.88 10.24 54 463619 2113 50139338
Gastroenteritis viral 19.79 10.24 261 463412 18525 50122926
Muscle spasms 19.78 10.24 944 462729 124609 50016842
Skin papilloma 19.74 10.24 84 463589 4145 50137306
Aspergillus infection 19.71 10.24 20 463653 6801 50134650
Acidosis 19.66 10.24 40 463633 10187 50131264
Myelosuppression 19.65 10.24 61 463612 13456 50127995
Oedema peripheral 19.62 10.24 1216 462457 156745 49984706
Oedema 19.61 10.24 491 463182 69690 50071761
Cardiomyopathy 19.51 10.24 75 463598 15511 50125940
Malaise 19.47 10.24 2736 460937 332796 49808655
Developmental hip dysplasia 19.36 10.24 39 463634 1252 50140199
Septic shock 19.10 10.24 389 463284 56786 50084665
Lethargy 19.09 10.24 328 463345 49104 50092347
Cyanosis 19.05 10.24 73 463600 15111 50126340
Aphasia 19.02 10.24 168 463505 28326 50113125
Malignant melanoma 19.01 10.24 158 463515 9950 50131501
Exposure to toxic agent 19.01 10.24 5 463668 3653 50137798
Ketoacidosis 18.99 10.24 6 463667 3889 50137562
Product substitution issue 18.68 10.24 66 463607 13991 50127460
Bradypnoea 18.45 10.24 3 463670 3071 50138380
Gastrointestinal disorder 18.45 10.24 1050 462623 93406 50048045
Pathogen resistance 18.44 10.24 15 463658 5674 50135777
Transplant dysfunction 18.35 10.24 10 463663 4674 50136777
Lip swelling 18.26 10.24 142 463531 24594 50116857
Fear 18.22 10.24 70 463603 14479 50126972
Musculoskeletal pain 18.13 10.24 822 462851 71355 50070096
Polyhydramnios 18.12 10.24 50 463623 1975 50139476
Skin cancer 17.76 10.24 147 463526 9247 50132204
Placental disorder 17.75 10.24 40 463633 1390 50140061
Cardiotoxicity 17.71 10.24 23 463650 7004 50134447
Loose body in joint 17.63 10.24 36 463637 1167 50140284
Pneumonia viral 17.61 10.24 22 463651 6812 50134639
Glycosylated haemoglobin increased 17.54 10.24 45 463628 10561 50130890
Epstein-Barr virus infection 17.54 10.24 23 463650 6974 50134477
Diabetes mellitus 17.47 10.24 330 463343 48703 50092748
Body tinea 17.46 10.24 38 463635 1289 50140162
Sinus bradycardia 17.45 10.24 62 463611 13121 50128330
Paralysis 17.42 10.24 33 463640 8631 50132820
Synovial fluid analysis 17.27 10.24 43 463630 1595 50139856
Rebound effect 17.27 10.24 4 463669 3185 50138266
Device related infection 17.26 10.24 115 463558 20620 50120831
Salivary hypersecretion 17.21 10.24 21 463652 6570 50134881
Renal injury 17.14 10.24 33 463640 8578 50132873
Foot fracture 17.13 10.24 269 463404 19822 50121629
Circulatory collapse 17.12 10.24 110 463563 19890 50121561
Dysgeusia 17.11 10.24 252 463421 38664 50102787
Crying 17.11 10.24 113 463560 20303 50121148
Subdural haematoma 17.06 10.24 61 463612 12886 50128565
Haemoptysis 16.98 10.24 151 463522 25422 50116029
Acute respiratory failure 16.96 10.24 175 463498 28607 50112844
Foot operation 16.83 10.24 97 463576 5413 50136038
Impaired quality of life 16.83 10.24 104 463569 5952 50135499
Skin ulcer 16.71 10.24 433 463240 34885 50106566
Delusion 16.60 10.24 46 463627 10523 50130928
Hepatitis cholestatic 16.50 10.24 19 463654 6098 50135353
Swollen tongue 16.49 10.24 175 463498 28455 50112996
Feeling abnormal 16.47 10.24 961 462712 124531 50016920
Muscle twitching 16.41 10.24 79 463594 15352 50126099
Mood altered 16.29 10.24 61 463612 12712 50128739
Complication associated with device 16.19 10.24 74 463599 14581 50126870
Stomatitis 16.17 10.24 1107 462566 100237 50041214
Uterine perforation 16.17 10.24 21 463652 6394 50135057
Bronchitis 16.14 10.24 1135 462538 103024 50038427
Acute pulmonary oedema 16.14 10.24 26 463647 7241 50134210
Dermatitis exfoliative 16.13 10.24 14 463659 5128 50136323
Catatonia 16.12 10.24 7 463666 3729 50137722
Pulmonary fibrosis 16.10 10.24 314 463359 24123 50117328
Graft versus host disease in gastrointestinal tract 16.06 10.24 3 463670 2778 50138673
Muscular weakness 16.04 10.24 709 462964 94304 50047147
Lupus vasculitis 15.99 10.24 21 463652 466 50140985
Nephrectomy 15.98 10.24 28 463645 807 50140644
Right ventricular failure 15.97 10.24 83 463590 15810 50125641
Deep vein thrombosis 15.90 10.24 531 463142 72773 50068678
Infection susceptibility increased 15.89 10.24 56 463617 2528 50138923
Intervertebral disc degeneration 15.88 10.24 191 463482 13270 50128181
Joint noise 15.79 10.24 70 463603 3517 50137934
Tenosynovitis 15.73 10.24 157 463516 10408 50131043
Catheter management 15.72 10.24 3 463670 2736 50138715
Synovial disorder 15.72 10.24 29 463644 871 50140580
Surgery 15.69 10.24 375 463298 29830 50111621
Macular degeneration 15.69 10.24 73 463600 14315 50127136
Pulmonary congestion 15.67 10.24 79 463594 15168 50126283
Breast feeding 15.67 10.24 28 463645 820 50140631
Endodontic procedure 15.60 10.24 58 463615 2688 50138763
Ataxia 15.60 10.24 69 463604 13717 50127734
Blood iron increased 15.59 10.24 37 463636 1331 50140120
Cytopenia 15.48 10.24 36 463637 8739 50132712
Flushing 15.36 10.24 482 463191 66533 50074918
Laryngospasm 15.31 10.24 3 463670 2685 50138766
Hypophosphataemia 15.26 10.24 34 463639 8380 50133071
Acute chest syndrome 15.21 10.24 24 463649 633 50140818
Peripheral sensory neuropathy 15.19 10.24 23 463650 6568 50134883
Crystal nephropathy 15.17 10.24 27 463646 788 50140663
Potentiating drug interaction 15.17 10.24 8 463665 3808 50137643
Pharyngitis streptococcal 15.16 10.24 135 463538 8673 50132778
Product prescribing error 15.16 10.24 121 463552 20840 50120611
Congenital arterial malformation 15.09 10.24 17 463656 320 50141131
Joint injury 15.05 10.24 282 463391 21507 50119944
Cystitis 15.04 10.24 524 463149 44040 50097411
Hyperprolactinaemia 15.01 10.24 6 463667 3359 50138092
Wrist fracture 14.89 10.24 166 463507 11321 50130130
Gallbladder polyp 14.88 10.24 25 463648 696 50140755
Foetal anticonvulsant syndrome 14.80 10.24 22 463651 550 50140901
Colitis microscopic 14.79 10.24 23 463650 6497 50134954
Medication error 14.78 10.24 237 463436 35867 50105584
Panic attack 14.77 10.24 110 463563 19232 50122219
Catheter site erythema 14.75 10.24 9 463664 3953 50137498
Dermatitis bullous 14.71 10.24 27 463646 7146 50134305
Low turnover osteopathy 14.70 10.24 74 463599 3920 50137531
Influenza 14.63 10.24 980 462693 88558 50052893
Atrioventricular block 14.55 10.24 23 463650 6455 50134996
Body temperature decreased 14.55 10.24 221 463452 16174 50125277
Wheezing 14.53 10.24 445 463228 61602 50079849
Embedded device 14.51 10.24 4 463669 2833 50138618
Bone disorder 14.47 10.24 247 463426 18505 50122946
Body height below normal 14.45 10.24 45 463628 1904 50139547
Polyuria 14.43 10.24 27 463646 7094 50134357
Cyst 14.41 10.24 173 463500 12014 50129437
Bone density decreased 14.34 10.24 160 463513 10915 50130536
Memory impairment 14.28 10.24 588 463085 78772 50062679
Inadequate analgesia 14.27 10.24 3 463670 2555 50138896
Crohn's disease 14.25 10.24 83 463590 4650 50136801
Pulmonary tuberculosis 14.23 10.24 77 463596 4196 50137255
Clear cell renal cell carcinoma 14.21 10.24 33 463640 1170 50140281
Generalised oedema 14.20 10.24 71 463602 13660 50127791
Affective disorder 14.07 10.24 16 463657 5165 50136286
Interstitial lung disease 14.06 10.24 375 463298 52801 50088650
Depressed mood 14.04 10.24 223 463450 33800 50107651
Squamous cell carcinoma 14.04 10.24 120 463553 7619 50133832
Ileus paralytic 14.00 10.24 10 463663 4040 50137411
Device breakage 13.94 10.24 43 463630 9504 50131947
Respiratory acidosis 13.93 10.24 21 463652 6007 50135444
Incoherent 13.91 10.24 11 463662 4219 50137232
Gastrooesophageal reflux disease 13.85 10.24 844 462829 75584 50065867
Acute coronary syndrome 13.85 10.24 42 463631 9332 50132119
Pulseless electrical activity 13.80 10.24 26 463647 6815 50134636
Hepatitis acute 13.77 10.24 33 463640 7928 50133523
Cestode infection 13.75 10.24 15 463658 272 50141179
Wound infection 13.73 10.24 171 463502 11977 50129474
Pericardial effusion 13.71 10.24 159 463514 25430 50116021
Cellulitis 13.62 10.24 786 462887 70012 50071439
Epilepsy 13.60 10.24 129 463544 21438 50120013
Coronary artery disease 13.59 10.24 191 463482 29535 50111916
Drug tolerance decreased 13.58 10.24 136 463537 9024 50132427
Injection site warmth 13.52 10.24 190 463483 13676 50127775
Atrial septal defect 13.51 10.24 102 463571 6239 50135212
Clostridium difficile colitis 13.50 10.24 101 463572 17641 50123810
Hyperammonaemia 13.48 10.24 14 463659 4710 50136741
Complication of device removal 13.47 10.24 11 463662 4153 50137298
Paranoia 13.47 10.24 49 463624 10299 50131152
Hepatic necrosis 13.41 10.24 17 463656 5231 50136220
Cytomegalovirus viraemia 13.39 10.24 14 463659 4695 50136756
Treatment noncompliance 13.34 10.24 195 463478 29955 50111496
Bradykinesia 13.28 10.24 10 463663 3933 50137518
Gestational hypertension 13.28 10.24 47 463626 2126 50139325
Abortion incomplete 13.26 10.24 6 463667 3120 50138331
Joint dislocation 13.26 10.24 172 463501 12161 50129290
Hyperuricaemia 13.21 10.24 14 463659 4666 50136785
Angina pectoris 13.17 10.24 165 463508 26023 50115428
Postoperative wound infection 13.13 10.24 127 463546 8348 50133103
Knee operation 13.11 10.24 83 463590 4790 50136661
Klebsiella infection 13.11 10.24 29 463644 7165 50134286
Hallucinations, mixed 13.08 10.24 11 463662 4092 50137359
Chronic graft versus host disease 12.98 10.24 5 463668 2862 50138589
Sexual dysfunction 12.94 10.24 7 463666 3285 50138166
Pregnancy with contraceptive device 12.92 10.24 11 463662 4068 50137383
Intracranial pressure increased 12.83 10.24 12 463661 4240 50137211
Lymphadenectomy 12.78 10.24 27 463646 897 50140554
Diabetes insipidus 12.73 10.24 3 463670 2361 50139090
Presyncope 12.72 10.24 151 463522 24047 50117404
Balance disorder 12.70 10.24 523 463150 70067 50071384
Dementia 12.68 10.24 90 463583 15907 50125544
Maternal exposure timing unspecified 12.58 10.24 66 463607 3554 50137897
Acute respiratory distress syndrome 12.55 10.24 128 463545 20971 50120480
Exomphalos 12.53 10.24 20 463653 533 50140918
Hiatus hernia 12.52 10.24 237 463436 18107 50123344
Hepatic encephalopathy 12.30 10.24 46 463627 9590 50131861
Dry eye 12.27 10.24 383 463290 31712 50109739
Haemorrhage in pregnancy 12.25 10.24 39 463634 1670 50139781
Red blood cell count decreased 12.22 10.24 401 463272 33434 50108017
Nervousness 12.18 10.24 179 463494 27472 50113979
Personality disorder 12.13 10.24 13 463660 4311 50137140
Affect lability 12.12 10.24 42 463631 8956 50132495
Catheter site pain 12.10 10.24 10 463663 3752 50137699
Adenovirus infection 12.07 10.24 7 463666 3161 50138290
Wrong product administered 12.07 10.24 19 463654 5341 50136110
Acute myocardial infarction 12.04 10.24 192 463481 29081 50112370
Dactylitis 12.02 10.24 41 463632 1820 50139631
Fracture 12.02 10.24 219 463454 16614 50124837
Product complaint 12.02 10.24 59 463614 11407 50130044
Hypernatraemia 11.92 10.24 25 463648 6296 50135155
Neonatal respiratory distress syndrome 11.84 10.24 52 463621 2602 50138849
Serum ferritin increased 11.84 10.24 85 463588 5117 50136334
Induced labour 11.83 10.24 26 463647 888 50140563
Talipes 11.76 10.24 34 463639 1380 50140071
Hyperthermia 11.72 10.24 34 463639 7662 50133789
Multiple-drug resistance 11.70 10.24 8 463665 3306 50138145
Hemiplegia 11.69 10.24 32 463641 7349 50134102
Device deployment issue 11.61 10.24 9 463664 3487 50137964
White blood cell count decreased 11.61 10.24 916 462757 115806 50025645
Hypervolaemia 11.60 10.24 164 463509 25335 50116116
Blood prolactin increased 11.59 10.24 7 463666 3092 50138359
Injection site haematoma 11.55 10.24 95 463578 5965 50135486
Red blood cell sedimentation rate 11.53 10.24 64 463609 3522 50137929
Gonorrhoea 11.50 10.24 9 463664 104 50141347
Hyperthyroidism 11.45 10.24 65 463608 12110 50129341
Hepatitis fulminant 11.38 10.24 7 463666 3061 50138390
Immunosuppression 11.37 10.24 111 463562 7315 50134136
Generalised tonic-clonic seizure 11.35 10.24 171 463502 26139 50115312
Lymphocyte count decreased 11.34 10.24 171 463502 26136 50115315
Abdominal pain upper 11.33 10.24 1645 462028 157664 49983787
Scleritis 11.33 10.24 59 463614 3168 50138283
Mixed liver injury 11.31 10.24 9 463664 3442 50138009
Renal mass 11.31 10.24 41 463632 1877 50139574
Cervical incompetence 11.28 10.24 20 463653 582 50140869
Transaminases increased 11.27 10.24 183 463490 27641 50113810
Coronary arterial stent insertion 11.26 10.24 5 463668 2629 50138822
Product administered to patient of inappropriate age 11.24 10.24 5 463668 2625 50138826
Dislocation of vertebra 11.23 10.24 57 463616 3030 50138421
Visual impairment 11.21 10.24 511 463162 67764 50073687
Cholestasis of pregnancy 11.21 10.24 29 463644 1102 50140349
Speech disorder developmental 11.21 10.24 20 463653 585 50140866
Colitis 11.19 10.24 268 463405 38261 50103190
Anhedonia 11.18 10.24 47 463626 9477 50131974
Stillbirth 11.18 10.24 93 463580 5859 50135592
Lupus nephritis 11.17 10.24 47 463626 2308 50139143
Pulmonary haemorrhage 11.16 10.24 27 463646 6465 50134986
Drug abuser 11.14 10.24 6 463667 2822 50138629
Exostosis 11.09 10.24 159 463514 11494 50129957
Cushingoid 11.01 10.24 101 463572 6544 50134907
Drug screen positive 10.99 10.24 9 463664 3393 50138058
Foetal death 10.97 10.24 119 463554 8061 50133390
Mucosal inflammation 10.90 10.24 282 463391 39860 50101591
Eye infection 10.89 10.24 133 463540 9273 50132178
Progressive multifocal leukoencephalopathy 10.86 10.24 61 463612 11396 50130055
Chondropathy 10.82 10.24 43 463630 2057 50139394
Hyperbilirubinaemia 10.77 10.24 48 463625 9522 50131929
Haematocrit decreased 10.76 10.24 407 463266 34569 50106882
Device issue 10.74 10.24 124 463549 19848 50121603
Hypertelorism 10.74 10.24 16 463657 401 50141050
Antinuclear antibody positive 10.73 10.24 96 463577 6176 50135275
Leukocytosis 10.71 10.24 144 463529 22435 50119016
Jaundice cholestatic 10.69 10.24 19 463654 5092 50136359
Human antichimeric antibody positive 10.69 10.24 34 463639 1455 50139996
Hypoglycaemic coma 10.67 10.24 4 463669 2329 50139122
Amylase increased 10.64 10.24 21 463652 5409 50136042
Infective pulmonary exacerbation of cystic fibrosis 10.60 10.24 37 463636 7872 50133579
Anti-neutrophil cytoplasmic antibody positive vasculitis 10.59 10.24 4 463669 2318 50139133
Somnambulism 10.58 10.24 18 463655 4906 50136545
Mental disorder 10.52 10.24 140 463533 21851 50119600
Cartilage injury 10.46 10.24 36 463637 1606 50139845
Granulocytopenia 10.45 10.24 20 463653 5211 50136240
Haemodynamic instability 10.44 10.24 38 463635 7986 50133465
Product adhesion issue 10.44 10.24 15 463658 4377 50137074
Injection site irritation 10.44 10.24 72 463601 4278 50137173
Joint lock 10.41 10.24 42 463631 2023 50139428
Oxalosis 10.36 10.24 6 463667 40 50141411
Skin plaque 10.35 10.24 27 463646 6301 50135150
Autism spectrum disorder 10.26 10.24 21 463652 682 50140769

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 422.57 10.14 716 174752 31436 29367623
Toxicity to various agents 324.88 10.14 331 175137 173330 29225729
Drug abuse 290.44 10.14 60 175408 79823 29319236
Completed suicide 271.57 10.14 98 175370 90148 29308911
Foetal exposure during pregnancy 210.16 10.14 555 174913 33312 29365747
Drug interaction 190.26 10.14 572 174896 196813 29202246
Arthralgia 190.16 10.14 1448 174020 138169 29260890
Psoriatic arthropathy 139.92 10.14 285 175183 14406 29384653
Intentional overdose 117.24 10.14 41 175427 38487 29360572
Dysmorphism 107.24 10.14 109 175359 2862 29396197
Joint swelling 103.15 10.14 573 174895 49057 29350002
Acute kidney injury 96.44 10.14 1058 174410 264209 29134850
Psoriasis 92.57 10.14 408 175060 31819 29367240
Nasopharyngitis 91.45 10.14 637 174831 59028 29340031
Sickle cell anaemia with crisis 87.50 10.14 92 175376 2516 29396543
Drug reaction with eosinophilia and systemic symptoms 81.44 10.14 32 175436 27960 29371099
Overdose 75.48 10.14 233 175235 79586 29319473
Suicide attempt 73.21 10.14 57 175411 34053 29365006
Premature baby 71.02 10.14 245 175223 17035 29382024
Enthesopathy 69.71 10.14 98 175370 3645 29395414
Rhabdomyolysis 66.81 10.14 165 175303 60643 29338416
Exposure during pregnancy 66.62 10.14 153 175315 8401 29390658
Speech disorder developmental 65.28 10.14 68 175400 1839 29397220
Pain 64.52 10.14 1399 174069 170033 29229026
Musculoskeletal stiffness 64.04 10.14 411 175057 37047 29362012
Coma 63.03 10.14 85 175383 39365 29359694
Serotonin syndrome 61.86 10.14 14 175454 17498 29381561
Blood pressure fluctuation 61.84 10.14 258 175210 19636 29379423
Product use in unapproved indication 61.72 10.14 285 175183 86590 29312469
Hepatic function abnormal 61.30 10.14 86 175382 39173 29359886
Neonatal respiratory distress syndrome 59.75 10.14 92 175376 3718 29395341
Tenosynovitis 55.56 10.14 88 175380 3645 29395414
Febrile neutropenia 55.33 10.14 414 175054 111826 29287233
Foetal anticonvulsant syndrome 53.92 10.14 49 175419 1115 29397944
Hypospadias 50.65 10.14 75 175393 2927 29396132
Arthritis 49.40 10.14 285 175183 24734 29374325
Death 49.36 10.14 1601 173867 340483 29058576
Atrial septal defect 48.06 10.14 117 175351 6672 29392387
Renal failure 46.61 10.14 464 175004 118135 29280924
Cytomegalovirus infection 45.88 10.14 42 175426 23173 29375886
Coombs positive haemolytic anaemia 45.73 10.14 37 175431 715 29398344
Autism spectrum disorder 45.17 10.14 58 175410 1974 29397085
Haemoglobin decreased 44.47 10.14 896 174572 107479 29291580
Maternal drugs affecting foetus 43.74 10.14 81 175387 3812 29395247
Respiratory arrest 42.96 10.14 54 175414 25779 29373280
Maternal exposure during pregnancy 42.87 10.14 83 175385 4040 29395019
Hypoglycaemia neonatal 42.79 10.14 52 175416 1672 29397387
Drug resistance 42.53 10.14 39 175429 21501 29377558
Cardiac failure 42.19 10.14 286 175182 79001 29320058
Foot deformity 41.96 10.14 81 175387 3934 29395125
Low birth weight baby 41.68 10.14 109 175359 6499 29392560
Learning disorder 41.53 10.14 40 175428 982 29398077
Infusion related reaction 41.26 10.14 420 175048 43466 29355593
Cryptorchism 40.94 10.14 54 175414 1888 29397171
Peripheral swelling 39.71 10.14 564 174904 63175 29335884
Small for dates baby 39.63 10.14 74 175394 3505 29395554
Juvenile idiopathic arthritis 39.50 10.14 45 175423 1349 29397710
Pain in extremity 39.50 10.14 895 174573 109538 29289521
Angioedema 38.76 10.14 82 175386 31833 29367226
Basal cell carcinoma 38.33 10.14 200 175268 16710 29382349
Maternal exposure during breast feeding 37.17 10.14 45 175423 1441 29397618
Depressed level of consciousness 36.94 10.14 105 175363 36837 29362222
Osteoarthritis 36.91 10.14 208 175260 17895 29381164
Synovitis 36.84 10.14 145 175323 10745 29388314
Sedation 36.20 10.14 30 175438 17375 29381684
Renal impairment 35.46 10.14 310 175158 81023 29318036
C-reactive protein abnormal 35.44 10.14 102 175366 6434 29392625
Haemolysis 35.27 10.14 106 175362 6850 29392209
Blood pressure systolic abnormal 35.04 10.14 53 175415 2108 29396951
Arthropathy 34.10 10.14 232 175236 21322 29377737
Lactic acidosis 33.26 10.14 82 175386 30165 29368894
Ventricular septal defect 33.05 10.14 68 175400 3461 29395598
Tongue disorder 32.92 10.14 80 175388 4556 29394503
Bradycardia 32.82 10.14 241 175227 65388 29333671
Syndactyly 32.76 10.14 31 175437 744 29398315
Immune reconstitution inflammatory syndrome 32.50 10.14 4 175464 7798 29391261
Grip strength decreased 32.44 10.14 53 175415 2254 29396805
Suicidal ideation 31.62 10.14 103 175365 34613 29364446
Poisoning 31.50 10.14 10 175458 9983 29389076
Cardiac arrest 31.50 10.14 340 175128 85251 29313808
Fatigue 30.96 10.14 2229 173239 314592 29084467
Altered state of consciousness 30.61 10.14 44 175424 19845 29379214
Victim of child abuse 30.49 10.14 31 175437 814 29398245
Rheumatoid nodule 30.18 10.14 49 175419 2073 29396986
Joint laxity 29.56 10.14 22 175446 374 29398685
Substance abuse 29.48 10.14 3 175465 6784 29392275
Intellectual disability 29.37 10.14 35 175433 1102 29397957
Delirium 29.30 10.14 127 175341 39270 29359789
Developmental delay 29.06 10.14 53 175415 2465 29396594
Blood pressure systolic increased 28.88 10.14 185 175283 16660 29382399
Palmar-plantar erythrodysaesthesia syndrome 28.81 10.14 27 175441 14732 29384327
Shock 28.58 10.14 52 175416 21352 29377707
Psychotic disorder 28.49 10.14 48 175420 20306 29378753
Agitation 28.32 10.14 183 175285 51121 29347938
Intentional product misuse 28.12 10.14 108 175360 34553 29364506
Congenital hand malformation 27.98 10.14 25 175443 556 29398503
Pulmonary fibrosis 27.88 10.14 173 175295 15409 29383650
Intentional self-injury 27.79 10.14 20 175448 12441 29386618
Exposure via breast milk 27.78 10.14 42 175426 1670 29397389
Neuroleptic malignant syndrome 27.65 10.14 33 175435 16115 29382944
Blood pressure increased 27.58 10.14 602 174866 73201 29325858
Lower respiratory tract infection 27.53 10.14 259 175209 26243 29372816
Blood creatine phosphokinase increased 27.28 10.14 136 175332 40508 29358551
Electrocardiogram QT prolonged 27.18 10.14 116 175352 36021 29363038
Hypermobility syndrome 26.97 10.14 20 175448 338 29398721
Hypoglycaemia 26.91 10.14 172 175296 48174 29350885
Lymphadenitis 26.90 10.14 40 175428 1567 29397492
Somnolence 26.80 10.14 394 175074 93561 29305498
Alanine aminotransferase abnormal 26.54 10.14 56 175412 2901 29396158
Talipes 26.33 10.14 42 175426 1750 29397309
Weight decreased 26.01 10.14 1119 174349 149786 29249273
Toxic epidermal necrolysis 25.23 10.14 43 175425 18110 29380949
Astigmatism 25.14 10.14 30 175438 946 29398113
Jaundice neonatal 25.06 10.14 34 175434 1222 29397837
Muscle swelling 25.04 10.14 19 175449 333 29398726
Blood pressure diastolic abnormal 24.89 10.14 50 175418 2501 29396558
Cellulitis 24.80 10.14 396 175072 45444 29353615
Drug withdrawal syndrome 24.63 10.14 43 175425 17941 29381118
Tendonitis 23.77 10.14 102 175366 7859 29391200
Foetal growth restriction 23.62 10.14 62 175406 3704 29395355
Language disorder 23.58 10.14 42 175426 1917 29397142
Joint effusion 23.37 10.14 66 175402 4118 29394941
Acute hepatic failure 23.17 10.14 22 175446 11930 29387129
Plagiocephaly 23.00 10.14 21 175447 481 29398578
Rash maculo-papular 22.86 10.14 71 175397 24218 29374841
Cholestasis 22.50 10.14 68 175400 23394 29375665
Large for dates baby 22.41 10.14 27 175441 860 29398199
Scoliosis 22.34 10.14 45 175423 2255 29396804
Sinusitis 22.20 10.14 306 175162 34044 29365015
Status epilepticus 21.96 10.14 19 175449 10775 29388284
Agranulocytosis 21.70 10.14 56 175412 20284 29378775
Hepatocellular injury 21.52 10.14 60 175408 21183 29377876
Vitamin D deficiency 21.51 10.14 77 175391 5452 29393607
Blood pressure diastolic increased 21.43 10.14 59 175409 3627 29395432
Post procedural infection 21.26 10.14 65 175403 4240 29394819
Skin cancer 21.19 10.14 103 175365 8365 29390694
Hyperglycaemia 21.18 10.14 118 175350 34169 29364890
Hyperbilirubinaemia neonatal 21.11 10.14 24 175444 718 29398341
Hand deformity 21.08 10.14 42 175426 2088 29396971
Knee deformity 21.01 10.14 21 175447 540 29398519
Knee arthroplasty 21.00 10.14 79 175389 5730 29393329
Wound 21.00 10.14 133 175335 11930 29387129
Neurotoxicity 20.88 10.14 34 175434 14579 29384480
Polyarthritis 20.84 10.14 61 175407 3884 29395175
Diabetic ketoacidosis 20.62 10.14 40 175428 16033 29383026
Strabismus 20.55 10.14 33 175435 1383 29397676
Selective eating disorder 20.47 10.14 36 175432 1627 29397432
Multiple organ dysfunction syndrome 20.39 10.14 258 175210 62858 29336201
Serum ferritin increased 20.21 10.14 76 175392 5512 29393547
Behaviour disorder 20.16 10.14 57 175411 3559 29395500
Therapeutic product effect decreased 20.12 10.14 265 175203 29186 29369873
Skin lesion 20.04 10.14 183 175285 18389 29380670
Motor developmental delay 19.89 10.14 22 175446 638 29398421
Otitis media 19.82 10.14 46 175422 2543 29396516
Oropharyngeal pain 19.80 10.14 263 175205 29022 29370037
Incorrect route of product administration 19.66 10.14 21 175447 10780 29388279
Pyrexia 19.54 10.14 1456 174012 286166 29112893
Drug intolerance 19.48 10.14 399 175069 47980 29351079
Encephalitis toxic 19.34 10.14 15 175453 272 29398787
Lung hernia 19.22 10.14 9 175459 60 29398999
Caesarean section 19.13 10.14 38 175430 1885 29397174
Localised infection 19.12 10.14 144 175324 13672 29385387
Influenza 19.10 10.14 352 175116 41529 29357530
Back disorder 18.98 10.14 78 175390 5895 29393164
Aspergillus infection 18.79 10.14 21 175447 10560 29388499
Musculoskeletal pain 18.74 10.14 258 175210 28695 29370364
Venoocclusive liver disease 18.39 10.14 9 175459 6908 29392151
Drug level increased 18.34 10.14 54 175414 18733 29380326
Back pain 18.17 10.14 761 174707 101523 29297536
Progressive multifocal leukoencephalopathy 18.16 10.14 15 175453 8704 29390355
Mass 18.16 10.14 87 175381 7024 29392035
Hepatic failure 18.11 10.14 111 175357 31401 29367658
Proteinuria 18.04 10.14 42 175426 15762 29383297
Hepatic enzyme increased 17.91 10.14 291 175177 33508 29365551
Dysgraphia 17.61 10.14 38 175430 2000 29397059
Crystal nephropathy 17.57 10.14 16 175452 365 29398694
Dyslexia 17.42 10.14 15 175453 317 29398742
Immunodeficiency 17.42 10.14 62 175406 4378 29394681
Heart rate decreased 17.37 10.14 225 175243 24687 29374372
Crohn's disease 17.33 10.14 48 175420 2961 29396098
Disease progression 17.12 10.14 363 175105 81553 29317506
Medical device implantation 17.04 10.14 19 175449 556 29398503
Body temperature decreased 16.99 10.14 115 175353 10549 29388510
Joint range of motion decreased 16.88 10.14 76 175392 5978 29393081
Dyspraxia 16.87 10.14 16 175452 385 29398674
Hypotonia neonatal 16.80 10.14 28 175440 1211 29397848
Arthritis bacterial 16.78 10.14 61 175407 4352 29394707
Aggression 16.59 10.14 133 175335 35408 29363651
Haematocrit decreased 16.56 10.14 253 175215 28769 29370290
Attention deficit hyperactivity disorder 16.54 10.14 39 175429 2178 29396881
Cytokine release syndrome 16.53 10.14 33 175435 13086 29385973
Drug withdrawal syndrome neonatal 16.52 10.14 51 175417 3344 29395715
Malignant melanoma 16.44 10.14 85 175383 7076 29391983
Anaphylactic shock 16.41 10.14 34 175434 13302 29385757
Akathisia 16.14 10.14 10 175458 6732 29392327
Red blood cell count decreased 16.11 10.14 227 175241 25375 29373684
Product quality issue 16.02 10.14 45 175423 15850 29383209
Second primary malignancy 15.98 10.14 10 175458 6695 29392364
Anal fistula 15.96 10.14 58 175410 4137 29394922
Cardio-respiratory arrest 15.91 10.14 208 175260 50393 29348666
Blood pressure diastolic decreased 15.88 10.14 83 175385 6939 29392120
Agitation neonatal 15.86 10.14 25 175443 1031 29398028
Lacrimal disorder 15.76 10.14 14 175454 309 29398750
Pancytopenia 15.74 10.14 623 174845 82545 29316514
Congenital bladder anomaly 15.70 10.14 13 175455 260 29398799
Nephrolithiasis 15.69 10.14 224 175244 25110 29373949
Tachycardia 15.68 10.14 319 175149 72091 29326968
Limb reduction defect 15.65 10.14 13 175455 261 29398798
Cleft lip 15.65 10.14 14 175454 312 29398747
Mean cell volume increased 15.64 10.14 41 175427 2448 29396611
Hyperammonaemia 15.62 10.14 7 175461 5656 29393403
Bronchopulmonary aspergillosis 15.59 10.14 31 175437 12313 29386746
Cerebral haemorrhage 15.42 10.14 116 175352 31310 29367749
Weight decrease neonatal 15.39 10.14 14 175454 319 29398740
Foetal disorder 15.33 10.14 21 175447 762 29398297
Hydrocele 15.28 10.14 35 175433 1918 29397141
Congenital foot malformation 15.00 10.14 15 175453 386 29398673
Multiple congenital abnormalities 14.99 10.14 17 175451 507 29398552
Stevens-Johnson syndrome 14.98 10.14 49 175419 16448 29382611
Poor venous access 14.94 10.14 47 175421 3114 29395945
Ear disorder 14.93 10.14 27 175441 1247 29397812
Colitis ulcerative 14.90 10.14 128 175340 12641 29386418
Acute graft versus host disease 14.85 10.14 8 175460 5816 29393243
Renal aplasia 14.79 10.14 19 175449 647 29398412
Haemorrhage intracranial 14.78 10.14 41 175427 14501 29384558
Kidney infection 14.76 10.14 61 175407 4622 29394437
Ankyloglossia congenital 14.74 10.14 13 175455 284 29398775
Myoclonus 14.69 10.14 36 175432 13273 29385786
Pneumonia 14.65 10.14 2139 173329 318033 29081026
Suspected suicide 14.63 10.14 3 175465 4017 29395042
Pathogen resistance 14.53 10.14 16 175452 8100 29390959
Microcephaly 14.51 10.14 20 175448 730 29398329
Neck mass 14.42 10.14 29 175439 1452 29397607
Inguinal hernia 14.40 10.14 78 175390 6610 29392449
Septic arthritis staphylococcal 14.38 10.14 16 175452 467 29398592
Osteonecrosis of jaw 14.34 10.14 50 175418 16460 29382599
Congenital anomaly 14.13 10.14 27 175441 1301 29397758
Interstitial lung disease 14.12 10.14 249 175219 57469 29341590
Stiff person syndrome 14.11 10.14 8 175460 83 29398976
Inflammation 14.09 10.14 201 175267 22527 29376532
Spinal disorder 13.99 10.14 51 175417 3644 29395415
Bronchiolitis 13.98 10.14 42 175426 2713 29396346
Haemangioma congenital 13.96 10.14 16 175452 483 29398576
Urinary tract infection 13.92 10.14 543 174925 71811 29327248
Ear infection 13.91 10.14 89 175379 8011 29391048
Eosinophilia 13.83 10.14 76 175392 22085 29376974
Hepatic encephalopathy 13.82 10.14 36 175432 12999 29386060
Malignant neoplasm progression 13.82 10.14 333 175135 73526 29325533
Posterior reversible encephalopathy syndrome 13.67 10.14 20 175448 8956 29390103
Nasal disorder 13.66 10.14 28 175440 1421 29397638
Pectus excavatum 13.62 10.14 11 175457 212 29398847
Tuberculosis 13.57 10.14 81 175387 7115 29391944
Hypocalcaemia 13.38 10.14 70 175398 20595 29378464
Arthrodesis 13.34 10.14 15 175453 443 29398616
Metabolic acidosis 13.29 10.14 151 175317 37511 29361548
Lipase increased 13.27 10.14 18 175450 8319 29390740
Vomiting 13.21 10.14 1082 174386 211178 29187881
Electrocardiogram QRS complex prolonged 13.16 10.14 4 175464 4106 29394953
Oesophageal fibrosis 13.14 10.14 10 175458 176 29398883
Drug-induced liver injury 13.12 10.14 75 175393 21580 29377479
Spinal stenosis 13.10 10.14 56 175412 4307 29394752
Diaphragmatic disorder 13.06 10.14 22 175446 960 29398099
Transaminases increased 12.93 10.14 80 175388 22582 29376477
Haemangioma 12.86 10.14 30 175438 1664 29397395
Off label use 12.83 10.14 1576 173892 299224 29099835
Pleural fibrosis 12.83 10.14 26 175442 1309 29397750
Hypokalaemia 12.79 10.14 215 175253 49988 29349071
Disseminated intravascular coagulation 12.76 10.14 68 175400 19912 29379147
Chronic graft versus host disease 12.75 10.14 4 175464 4025 29395034
Synovial cyst 12.69 10.14 32 175436 1865 29397194
Patent ductus arteriosus 12.52 10.14 44 175424 3087 29395972
Upper respiratory tract infection 12.51 10.14 230 175238 27119 29371940
Hypertransaminasaemia 12.50 10.14 3 175465 3603 29395456
Hypertelorism 12.50 10.14 16 175452 543 29398516
Bradycardia neonatal 12.42 10.14 21 175447 919 29398140
Cystatin C increased 12.40 10.14 3 175465 0 29399059
Acute generalised exanthematous pustulosis 12.40 10.14 9 175459 5574 29393485
Wrong technique in product usage process 12.30 10.14 123 175345 31305 29367754
Vitamin B12 deficiency 12.26 10.14 45 175423 3226 29395833
Full blood count decreased 12.25 10.14 147 175321 15845 29383214
Maternal exposure timing unspecified 12.20 10.14 13 175455 361 29398698
Obsessive-compulsive disorder 12.09 10.14 6 175462 4570 29394489
Psychomotor retardation 12.05 10.14 42 175426 2934 29396125
Therapy partial responder 12.05 10.14 8 175460 5191 29393868
Gastric haemorrhage 12.04 10.14 23 175445 9274 29389785
Arnold-Chiari malformation 12.02 10.14 12 175456 308 29398751
Loss of personal independence in daily activities 12.01 10.14 215 175253 25225 29373834
Loss of consciousness 11.97 10.14 341 175127 73715 29325344
Headache 11.96 10.14 1193 174275 172814 29226245
Thrombocytopenia 11.95 10.14 666 174802 134157 29264902
Hernia pain 11.94 10.14 11 175457 255 29398804
Finger deformity 11.92 10.14 23 175445 1117 29397942
Polydactyly 11.92 10.14 23 175445 1117 29397942
Cystitis haemorrhagic 11.85 10.14 7 175461 4835 29394224
Cytomegalovirus viraemia 11.83 10.14 12 175456 6308 29392751
Hypotension 11.74 10.14 993 174475 193361 29205698
Respiratory disorder neonatal 11.66 10.14 26 175442 1399 29397660
Neutrophil count decreased 11.62 10.14 185 175283 43382 29355677
Adenovirus infection 11.50 10.14 6 175462 4441 29394618
Drug dependence 11.49 10.14 75 175393 20906 29378153
Tooth malformation 11.43 10.14 9 175459 167 29398892
Skin abrasion 11.42 10.14 69 175399 6087 29392972
Hallucination, visual 11.41 10.14 48 175420 14967 29384092
Cardiotoxicity 11.41 10.14 7 175461 4737 29394322
Chronic obstructive pulmonary disease 11.38 10.14 321 175147 40634 29358425
Meningeal disorder 11.33 10.14 12 175456 331 29398728
C-reactive protein decreased 11.27 10.14 27 175441 1524 29397535
Tonsil cancer 11.26 10.14 20 175448 911 29398148
BK virus infection 11.24 10.14 7 175461 4700 29394359
Vascular insufficiency 11.24 10.14 12 175456 334 29398725
Cerebral infarction 11.21 10.14 93 175375 24582 29374477
Radiation inflammation 11.21 10.14 10 175458 222 29398837
Anal atresia 11.19 10.14 11 175457 277 29398782
Hyperbilirubinaemia 11.19 10.14 48 175420 14886 29384173
Hyperkalaemia 11.15 10.14 278 175190 61114 29337945
Prostate cancer 11.10 10.14 213 175255 25314 29373745
Contusion 11.09 10.14 252 175216 30843 29368216
Joint stiffness 11.07 10.14 95 175373 9378 29389681
Acute graft versus host disease in skin 11.05 10.14 7 175461 4657 29394402
Infected bite 11.04 10.14 12 175456 341 29398718
Developmental coordination disorder 11.04 10.14 9 175459 176 29398883
Medication error 11.03 10.14 77 175391 21134 29377925
Spina bifida 11.01 10.14 12 175456 342 29398717
Injection site pain 10.97 10.14 261 175207 32185 29366874
Renal injury 10.95 10.14 28 175440 10174 29388885
Foetal heart rate deceleration abnormality 10.94 10.14 14 175454 475 29398584
Epidural lipomatosis 10.91 10.14 17 175451 694 29398365
Hallucination 10.90 10.14 193 175275 44519 29354540
Blood insulin increased 10.88 10.14 12 175456 347 29398712
Pharyngeal disorder 10.87 10.14 16 175452 621 29398438
Arthropod bite 10.87 10.14 35 175433 2348 29396711
Nocardiosis 10.75 10.14 3 175465 3257 29395802
Neck pain 10.75 10.14 183 175285 21264 29377795
Graft versus host disease in gastrointestinal tract 10.74 10.14 3 175465 3255 29395804
Tubulointerstitial nephritis 10.74 10.14 61 175407 17582 29381477
Blood iron increased 10.72 10.14 18 175450 783 29398276
Extrapyramidal disorder 10.67 10.14 31 175437 10800 29388259
Mouth ulceration 10.65 10.14 101 175367 10254 29388805
Otitis externa 10.63 10.14 20 175448 953 29398106
Palindromic rheumatism 10.62 10.14 9 175459 186 29398873
Spinal operation 10.60 10.14 35 175433 2379 29396680
Lung neoplasm malignant 10.57 10.14 131 175337 14226 29384833
Oxygen saturation decreased 10.55 10.14 345 175123 44592 29354467
Hallucination, auditory 10.55 10.14 26 175442 9567 29389492
Ear malformation 10.54 10.14 11 175457 298 29398761
Respiratory rate increased 10.53 10.14 88 175380 8620 29390439
Cataract 10.52 10.14 189 175279 22189 29376870
Hepatitis fulminant 10.52 10.14 4 175464 3567 29395492
Diverticulum 10.52 10.14 69 175399 6263 29392796
Injection site bruising 10.48 10.14 79 175389 7501 29391558
Nephropathy toxic 10.44 10.14 31 175437 10725 29388334
Gangrene neonatal 10.38 10.14 9 175459 192 29398867
Neutropenia 10.35 10.14 658 174810 131053 29268006
Blood parathyroid hormone decreased 10.35 10.14 18 175450 806 29398253
Childhood asthma 10.34 10.14 3 175465 3 29399056
Aphasia 10.32 10.14 69 175399 19129 29379930
Ventricular tachycardia 10.29 10.14 85 175383 22489 29376570
Dystonia 10.27 10.14 27 175441 9722 29389337
Restlessness 10.27 10.14 83 175385 22062 29376997
Cardiac failure chronic 10.26 10.14 14 175454 6453 29392606
Bronchitis 10.25 10.14 289 175179 36579 29362480
Foetal distress syndrome 10.25 10.14 20 175448 979 29398080
Energy increased 10.22 10.14 22 175446 1156 29397903
Mobility decreased 10.17 10.14 212 175256 25568 29373491

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 1128.42 10.21 3220 475940 161074 63858498
Completed suicide 1106.83 10.21 172 478988 224242 63795330
Toxicity to various agents 968.23 10.21 770 478390 362743 63656829
Joint swelling 724.93 10.21 3345 475815 212037 63807535
Drug abuse 679.03 10.21 90 479070 132284 63887288
Arthropathy 654.02 10.21 2182 476978 118785 63900787
Pemphigus 615.36 10.21 1380 477780 59321 63960251
Pain 597.08 10.21 6506 472654 547005 63472567
Systemic lupus erythematosus 585.34 10.21 1575 477585 76037 63943535
Hand deformity 573.61 10.21 1370 477790 61401 63958171
Drug interaction 550.81 10.21 1167 477993 360916 63658656
Glossodynia 528.76 10.21 1353 477807 63343 63956229
Synovitis 521.87 10.21 1772 477388 97318 63922254
Arthralgia 521.25 10.21 5294 473866 436966 63582606
Infusion related reaction 475.88 10.21 2447 476713 162020 63857552
Maternal exposure during pregnancy 456.85 10.21 1659 477501 94225 63925347
Anti-cyclic citrullinated peptide antibody positive 416.91 10.21 1048 478112 48514 63971058
Wound 415.31 10.21 1382 477778 75095 63944477
Pericarditis 392.77 10.21 1188 477972 61328 63958244
Abdominal discomfort 391.75 10.21 2506 476654 179816 63839756
Nasopharyngitis 382.63 10.21 2631 476529 193442 63826130
Intentional overdose 376.69 10.21 101 479059 89843 63929729
Alopecia 353.19 10.21 2273 476887 163417 63856155
Contraindicated product administered 318.42 10.21 1614 477546 106215 63913357
Acute kidney injury 315.70 10.21 1999 477161 447241 63572331
Sinusitis 314.09 10.21 2007 477153 143921 63875651
Death 312.16 10.21 2202 476958 480503 63539069
Hepatic enzyme increased 295.75 10.21 1813 477347 128130 63891442
Therapeutic product effect decreased 289.27 10.21 1651 477509 113700 63905872
Swelling 288.58 10.21 2109 477051 158109 63861463
Discomfort 281.83 10.21 1270 477890 79608 63939964
Overdose 251.70 10.21 503 478657 159063 63860509
Rheumatoid factor positive 246.34 10.21 692 478468 34246 63985326
Febrile neutropenia 243.39 10.21 657 478503 187000 63832572
Peripheral swelling 241.33 10.21 2495 476665 206658 63812914
Exposure during pregnancy 238.68 10.21 1176 477984 76499 63943073
Lower respiratory tract infection 237.70 10.21 1355 477805 93259 63926313
Duodenal ulcer perforation 235.55 10.21 677 478483 33948 63985624
Helicobacter infection 235.27 10.21 723 478437 37639 63981933
Cardiac arrest 235.07 10.21 495 478665 153569 63866003
Musculoskeletal stiffness 224.75 10.21 1627 477533 121579 63897993
Suicide attempt 224.14 10.21 124 479036 70883 63948689
Psoriatic arthropathy 210.36 10.21 754 478406 42527 63977045
Drug intolerance 198.37 10.21 2203 476957 185789 63833783
Drug reaction with eosinophilia and systemic symptoms 196.84 10.21 78 479082 54139 63965433
Fatigue 178.70 10.21 7021 472139 741709 63277863
Rhabdomyolysis 177.95 10.21 253 478907 91473 63928099
Impaired healing 176.19 10.21 902 478258 59571 63960001
Hypersensitivity 174.19 10.21 2227 476933 194225 63825347
Cardiac failure 174.18 10.21 460 478700 131913 63887659
C-reactive protein abnormal 170.31 10.21 539 478621 28508 63991064
Respiratory arrest 166.54 10.21 93 479067 52892 63966680
Depressed level of consciousness 155.62 10.21 227 478933 81209 63938363
Sopor 154.83 10.21 19 479141 29642 63989930
Lactic acidosis 154.51 10.21 137 479023 61273 63958299
Blood pressure fluctuation 152.71 10.21 776 478384 51095 63968477
Renal failure 150.75 10.21 765 478395 180923 63838649
Arthritis 150.02 10.21 1102 478058 82712 63936860
Hepatic function abnormal 149.53 10.21 154 479006 64159 63955413
Immunodeficiency 145.12 10.21 350 478810 15774 64003798
Red blood cell sedimentation rate abnormal 144.67 10.21 352 478808 15954 64003618
Bradycardia 144.26 10.21 426 478734 117793 63901779
Sickle cell anaemia with crisis 139.76 10.21 185 478975 5147 64014425
Psoriasis 138.32 10.21 960 478200 70743 63948829
Product use issue 136.60 10.21 1725 477435 149990 63869582
Weight increased 131.97 10.21 2273 476887 211075 63808497
Muscle injury 127.97 10.21 460 478700 25977 63993595
Serotonin syndrome 127.77 10.21 66 479094 39216 63980356
Cytomegalovirus infection 126.30 10.21 59 479101 37140 63982432
Hip arthroplasty 125.90 10.21 397 478763 20954 63998618
Knee arthroplasty 124.96 10.21 463 478697 26536 63993036
Renal impairment 122.77 10.21 550 478610 134467 63885105
Cardio-respiratory arrest 120.44 10.21 354 478806 98039 63921533
Osteoarthritis 120.41 10.21 845 478315 62491 63957081
Malignant neoplasm progression 120.18 10.21 432 478728 112439 63907133
Neutropenia 119.08 10.21 1171 477989 238453 63781119
Sleep disorder due to general medical condition, insomnia type 116.20 10.21 444 478716 25826 63993746
Hypoglycaemia 114.74 10.21 317 478843 89575 63929997
Irritable bowel syndrome 113.48 10.21 564 478596 36805 63982767
Pregnancy 112.24 10.21 376 478784 20489 63999083
Electrocardiogram QT prolonged 111.53 10.21 267 478893 79181 63940391
Contusion 111.33 10.21 1316 477844 112649 63906923
Folliculitis 111.30 10.21 481 478679 29596 63989976
Abortion spontaneous 105.55 10.21 418 478742 24725 63994847
Drug resistance 105.51 10.21 65 479095 35037 63984535
Hyponatraemia 105.41 10.21 657 478503 147682 63871890
Hepatic failure 103.30 10.21 157 479003 55237 63964335
Coma 100.98 10.21 324 478836 87291 63932281
Product use in unapproved indication 100.86 10.21 833 478327 175785 63843787
Intentional self-injury 100.26 10.21 45 479115 28999 63990573
Blister 99.52 10.21 979 478181 79988 63939584
Hypotension 99.37 10.21 2116 477044 378858 63640714
Poisoning 98.59 10.21 21 479139 21858 63997714
Juvenile idiopathic arthritis 96.19 10.21 131 479029 3748 64015824
Multiple organ dysfunction syndrome 95.28 10.21 408 478752 101005 63918567
Treatment failure 95.02 10.21 1304 477856 115512 63904060
Agitation 94.87 10.21 337 478823 88030 63931542
Bursitis 94.10 10.21 362 478798 21123 63998449
Temperature regulation disorder 93.69 10.21 135 479025 4076 64015496
Ill-defined disorder 92.87 10.21 603 478557 43449 63976123
Rash 92.63 10.21 4228 474932 454321 63565251
Pain in extremity 90.58 10.21 2918 476242 300167 63719405
Injection site erythema 89.92 10.21 862 478298 69938 63949634
Thrombocytopenia 87.49 10.21 1154 478006 222647 63796925
Cholestasis 86.77 10.21 124 479036 44748 63974824
Tachycardia 85.15 10.21 706 478454 148873 63870699
Metabolic acidosis 84.88 10.21 258 478902 70700 63948872
Hepatocellular injury 84.55 10.21 128 479032 45107 63974465
Grip strength decreased 82.41 10.21 232 478928 11492 64008080
Respiratory failure 81.99 10.21 783 478377 160400 63859172
Fibromyalgia 81.47 10.21 499 478661 35232 63984340
Disseminated intravascular coagulation 80.36 10.21 73 479087 32275 63987297
Altered state of consciousness 80.18 10.21 98 479062 37804 63981768
Enthesopathy 80.17 10.21 203 478957 9435 64010137
Intentional product misuse 80.10 10.21 272 478888 72023 63947549
Disease progression 80.06 10.21 670 478490 141010 63878562
Hyperglycaemia 79.29 10.21 213 478947 60755 63958817
Blood pressure diastolic abnormal 79.10 10.21 231 478929 11686 64007886
Somnolence 77.80 10.21 1055 478105 202590 63816982
Injection site pruritus 77.44 10.21 514 478646 37312 63982260
Injection site reaction 76.98 10.21 602 478558 46062 63973510
Blood pressure systolic abnormal 76.12 10.21 203 478957 9739 64009833
Ear pain 76.05 10.21 379 478781 24757 63994815
Shock 75.61 10.21 104 479056 38136 63981436
Infection 75.32 10.21 1852 477308 183028 63836544
Sedation 74.00 10.21 121 479039 41341 63978231
Femur fracture 73.02 10.21 469 478691 33666 63985906
Blood pressure systolic increased 72.43 10.21 621 478539 48832 63970740
Hyperkalaemia 71.25 10.21 449 478711 100680 63918892
Joint effusion 70.88 10.21 241 478919 13232 64006340
Delirium 70.26 10.21 270 478890 68924 63950648
Neuroleptic malignant syndrome 70.11 10.21 50 479110 24946 63994626
Acute hepatic failure 69.68 10.21 55 479105 26057 63993515
Device expulsion 69.50 10.21 35 479125 21101 63998471
Food allergy 69.13 10.21 169 478991 7682 64011890
Angioedema 68.89 10.21 232 478928 61589 63957983
Osteoporosis 68.38 10.21 541 478619 41539 63978033
Disability assessment scale score increased 68.20 10.21 89 479071 2441 64017131
Blood creatine phosphokinase increased 66.46 10.21 218 478942 58340 63961232
Anaemia 65.95 10.21 2228 476932 376452 63643120
Injection site pain 65.95 10.21 1179 477981 110229 63909343
Coeliac disease 65.75 10.21 160 479000 7252 64012320
Leukopenia 65.55 10.21 461 478699 100781 63918791
Red blood cell sedimentation rate increased 64.88 10.21 426 478734 30809 63988763
Live birth 63.93 10.21 206 478954 10998 64008574
Muscle spasticity 62.76 10.21 268 478892 16401 64003171
Injection site swelling 61.99 10.21 522 478638 40831 63978741
Rheumatic fever 61.53 10.21 180 478980 9114 64010458
Syncope 60.78 10.21 815 478345 156820 63862752
Drug dependence 60.59 10.21 96 479064 33216 63986356
Immune reconstitution inflammatory syndrome 60.39 10.21 10 479150 12460 64007112
Blood pressure increased 59.45 10.21 1691 477469 170861 63848711
Foot deformity 58.82 10.21 261 478899 16243 64003329
Hypokalaemia 58.70 10.21 600 478560 121303 63898269
Drug ineffective 58.24 10.21 7108 472052 833139 63186433
Oropharyngeal pain 58.22 10.21 956 478204 87911 63931661
Diabetic ketoacidosis 58.17 10.21 82 479078 29763 63989809
Blood pressure diastolic decreased 57.68 10.21 322 478838 21979 63997593
Mydriasis 57.28 10.21 21 479139 15291 64004281
Loss of personal independence in daily activities 56.95 10.21 804 478356 71650 63947922
Heart rate decreased 56.92 10.21 643 478517 54424 63965148
Rheumatoid nodule 56.92 10.21 215 478945 12436 64007136
Swollen joint count increased 56.86 10.21 155 479005 7534 64012038
Upper respiratory tract infection 56.54 10.21 806 478354 71979 63947593
Localised infection 56.49 10.21 401 478759 29760 63989812
Musculoskeletal pain 56.43 10.21 883 478277 80411 63939161
Joint laxity 55.65 10.21 77 479083 2237 64017335
Cerebral haemorrhage 55.39 10.21 194 478966 50896 63968676
Night sweats 55.09 10.21 457 478703 35589 63983983
Tenosynovitis 54.82 10.21 203 478957 11630 64007942
Gastrointestinal disorder 54.74 10.21 954 478206 88755 63930817
Disorientation 54.67 10.21 221 478939 55607 63963965
Encephalopathy 54.40 10.21 238 478922 58581 63960991
Drug withdrawal syndrome 54.28 10.21 93 479067 31198 63988374
Extrapyramidal disorder 53.68 10.21 40 479120 19512 64000060
Caesarean section 53.56 10.21 195 478965 11079 64008493
Myocardial infarction 53.01 10.21 889 478271 164932 63854640
Palmar-plantar erythrodysaesthesia syndrome 52.46 10.21 83 479077 28736 63990836
Agranulocytosis 52.44 10.21 130 479030 38099 63981473
Blood pressure diastolic increased 51.11 10.21 186 478974 10566 64009006
Seizure 51.01 10.21 902 478258 165990 63853582
Myoclonus 50.99 10.21 67 479093 25051 63994521
Substance abuse 50.91 10.21 5 479155 9287 64010285
Venoocclusive liver disease 50.86 10.21 7 479153 10008 64009564
Joint stiffness 50.01 10.21 392 478768 30012 63989560
Cerebral infarction 49.96 10.21 148 479012 40896 63978676
Torsade de pointes 49.66 10.21 34 479126 17329 64002243
Drug level increased 49.52 10.21 113 479047 34083 63985489
Anaphylactic shock 49.15 10.21 94 479066 30234 63989338
Ventricular tachycardia 49.00 10.21 114 479046 34151 63985421
Suicidal ideation 48.65 10.21 292 478868 66250 63953322
Rash maculo-papular 48.06 10.21 183 478977 46843 63972729
Neurotoxicity 47.95 10.21 81 479079 27323 63992249
Inflammation 47.91 10.21 716 478444 64584 63954988
Psychotic disorder 47.89 10.21 117 479043 34461 63985111
Aggression 47.84 10.21 179 478981 46053 63973519
Injection site bruising 47.74 10.21 446 478714 35927 63983645
Hallucination 47.33 10.21 331 478829 72457 63947115
Eosinophilia 47.29 10.21 136 479024 37940 63981632
Herpes zoster 47.20 10.21 839 478321 78348 63941224
Aspergillus infection 46.95 10.21 32 479128 16347 64003225
Accidental overdose 46.90 10.21 113 479047 33444 63986128
Loss of consciousness 46.90 10.21 797 478363 147568 63872004
Status epilepticus 46.89 10.21 55 479105 21608 63997964
Carpal tunnel syndrome 46.71 10.21 237 478923 15591 64003981
Headache 46.53 10.21 4551 474609 524916 63494656
Posterior reversible encephalopathy syndrome 45.77 10.21 62 479098 22884 63996688
Basal cell carcinoma 45.55 10.21 388 478772 30450 63989122
Condition aggravated 44.84 10.21 3278 475882 369148 63650424
Abnormal behaviour 44.83 10.21 116 479044 33506 63986066
Transplant rejection 44.76 10.21 38 479122 17363 64002209
Gestational diabetes 44.69 10.21 116 479044 5474 64014098
Ischaemic stroke 44.48 10.21 93 479067 28942 63990630
Akathisia 44.40 10.21 15 479145 11495 64008077
Bronchopulmonary aspergillosis 44.01 10.21 46 479114 19039 64000533
Tongue disorder 43.78 10.21 192 478968 11888 64007684
Tremor 43.76 10.21 806 478354 147424 63872148
Polyarthritis 43.62 10.21 165 478995 9550 64010022
Influenza 43.60 10.21 1068 478092 105463 63914109
Bronchitis 43.55 10.21 1087 478073 107656 63911916
Oral herpes 43.53 10.21 298 478862 21854 63997718
Cytokine release syndrome 42.86 10.21 55 479105 20774 63998798
Inappropriate antidiuretic hormone secretion 42.69 10.21 62 479098 22227 63997345
Respiratory distress 42.41 10.21 222 478938 52109 63967463
Hypothermia 42.35 10.21 51 479109 19805 63999767
Gamma-glutamyltransferase increased 41.47 10.21 202 478958 48308 63971264
Proteinuria 41.46 10.21 90 479070 27633 63991939
Haematotoxicity 41.44 10.21 22 479138 12874 64006698
Ear infection 41.43 10.21 307 478853 23097 63996475
Hypoxia 41.15 10.21 437 478723 87712 63931860
Cardiac failure congestive 41.10 10.21 702 478458 129878 63889694
Spinal stenosis 40.70 10.21 208 478952 13723 64005849
Pre-eclampsia 40.60 10.21 120 479040 6111 64013461
Injection site rash 40.51 10.21 227 478933 15515 64004057
Acute graft versus host disease 40.36 10.21 9 479151 9075 64010497
Thrombotic microangiopathy 39.71 10.21 39 479121 16616 64002956
Toxic epidermal necrolysis 39.70 10.21 142 479018 37024 63982548
Haemorrhage intracranial 39.61 10.21 73 479087 23811 63995761
Interstitial lung disease 39.60 10.21 500 478660 97232 63922340
Bone erosion 39.55 10.21 181 478979 11414 64008158
Asphyxia 39.55 10.21 11 479149 9555 64010017
Premature delivery 39.50 10.21 255 478905 18334 64001238
Body temperature decreased 39.23 10.21 328 478832 25600 63993972
Psychomotor hyperactivity 39.11 10.21 30 479130 14421 64005151
Anaphylactic reaction 39.09 10.21 324 478836 68340 63951232
Joint injury 38.93 10.21 298 478862 22649 63996923
Disturbance in attention 38.71 10.21 165 478995 40909 63978663
Maternal exposure before pregnancy 38.46 10.21 82 479078 3401 64016171
Neutrophil count decreased 38.38 10.21 377 478783 76819 63942753
Ejection fraction decreased 38.30 10.21 99 479061 28608 63990964
Second primary malignancy 38.26 10.21 22 479138 12315 64007257
Synovial cyst 38.06 10.21 135 479025 7572 64012000
Restlessness 38.01 10.21 159 479001 39626 63979946
Miosis 37.91 10.21 26 479134 13240 64006332
Joint range of motion decreased 37.88 10.21 260 478900 19083 64000489
Pyrexia 37.66 10.21 3606 475554 555038 63464534
Body temperature increased 37.37 10.21 427 478733 36239 63983333
Melaena 37.06 10.21 239 478921 53309 63966263
Nodule 36.80 10.21 244 478916 17703 64001869
Mobility decreased 36.76 10.21 866 478294 84974 63934598
Laryngitis 36.74 10.21 171 478989 10860 64008712
Neuropathy peripheral 36.60 10.21 633 478527 116892 63902680
Sensitisation 36.35 10.21 54 479106 1677 64017895
Blood creatinine increased 36.22 10.21 751 478409 135031 63884541
Brain oedema 36.14 10.21 68 479092 22007 63997565
Unintentional medical device removal 35.92 10.21 4 479156 6730 64012842
Dyspnoea 35.92 10.21 4735 474425 713939 63305633
Tendonitis 35.88 10.21 266 478894 20016 63999556
Unresponsive to stimuli 35.86 10.21 223 478937 50170 63969402
Tenderness 35.77 10.21 259 478901 19343 64000229
Graft versus host disease 35.73 10.21 30 479130 13783 64005789
Neck deformity 35.36 10.21 53 479107 1659 64017913
Multiple fractures 35.32 10.21 112 479048 5928 64013644
Polycystic ovaries 35.28 10.21 60 479100 2095 64017477
Product administration error 34.87 10.21 98 479062 27545 63992027
Limb deformity 34.69 10.21 77 479083 3284 64016288
Toxic skin eruption 34.67 10.21 56 479104 19228 64000344
Back pain 34.65 10.21 2228 476932 247943 63771629
Bone disorder 34.46 10.21 228 478932 16531 64003041
Irritability 34.40 10.21 148 479012 36598 63982974
Hypertransaminasaemia 34.31 10.21 6 479154 7185 64012387
Hypomagnesaemia 34.10 10.21 152 479008 37224 63982348
Joint destruction 33.88 10.21 80 479080 3556 64016016
Arrhythmia 33.81 10.21 242 478918 52702 63966870
Fracture 33.76 10.21 247 478913 18508 64001064
Coombs positive haemolytic anaemia 33.74 10.21 37 479123 841 64018731
Arthritis infective 33.74 10.21 122 479038 6908 64012664
Blood bilirubin increased 33.47 10.21 270 478890 57283 63962289
Acute generalised exanthematous pustulosis 33.42 10.21 33 479127 14025 64005547
Premature rupture of membranes 33.40 10.21 81 479079 3663 64015909
Bradyphrenia 33.37 10.21 14 479146 9392 64010180
Osteonecrosis of jaw 33.37 10.21 167 478993 39658 63979914
Rhinorrhoea 32.81 10.21 627 478533 59342 63960230
Gastroenteritis viral 32.79 10.21 255 478905 19474 64000098
Ejection fraction 32.76 10.21 44 479116 1242 64018330
Pulmonary arterial hypertension 32.69 10.21 89 479071 25278 63994294
Foot fracture 32.61 10.21 239 478921 17918 64001654
Stomatitis 32.59 10.21 1055 478105 108550 63911022
Neck mass 32.41 10.21 84 479076 3960 64015612
Jaundice 32.33 10.21 219 478941 48293 63971279
Febrile bone marrow aplasia 32.24 10.21 22 479138 11233 64008339
Tachypnoea 32.20 10.21 96 479064 26475 63993097
Hyperthermia 32.06 10.21 41 479119 15509 64004063
Weight decreased 32.01 10.21 2501 476659 283238 63736334
Blood cholesterol increased 31.82 10.21 536 478624 49530 63970042
Crystal nephropathy 31.79 10.21 43 479117 1222 64018350
Haemophagocytic lymphohistiocytosis 31.78 10.21 51 479109 17558 64002014
Disability 31.64 10.21 176 478984 11996 64007576
Mental status changes 31.55 10.21 296 478864 60866 63958706
Pathogen resistance 31.52 10.21 28 479132 12515 64007057
Drug use disorder 31.30 10.21 4 479156 6050 64013522
Muscle rigidity 31.17 10.21 51 479109 17422 64002150
Smear cervix abnormal 31.10 10.21 60 479100 2314 64017258
Face oedema 31.07 10.21 88 479072 24673 63994899
Product quality issue 31.07 10.21 115 479045 29684 63989888
Hepatic encephalopathy 31 10.21 69 479091 20997 63998575
Stevens-Johnson syndrome 30.81 10.21 140 479020 34109 63985463
Red blood cell sedimentation rate 30.65 10.21 78 479082 3636 64015936
Hyperammonaemia 30.24 10.21 18 479142 9886 64009686
Alanine aminotransferase abnormal 30.11 10.21 116 479044 6772 64012800
Acute graft versus host disease in skin 30.04 10.21 7 479153 6848 64012724
Shock haemorrhagic 29.96 10.21 49 479111 16742 64002830
Vomiting 29.96 10.21 3611 475549 547506 63472066
Hyperbilirubinaemia 29.96 10.21 71 479089 21134 63998438
Dyskinesia 29.77 10.21 171 478989 39217 63980355
BK virus infection 29.76 10.21 9 479151 7403 64012169
Red blood cell count decreased 29.66 10.21 515 478645 47871 63971701
Skin ulcer 29.51 10.21 475 478685 43499 63976073
Labelled drug-drug interaction medication error 29.50 10.21 76 479084 21986 63997586
Polyneuropathy 29.41 10.21 65 479095 19829 63999743
Latent tuberculosis 29.40 10.21 64 479096 2693 64016879
Drug-induced liver injury 29.35 10.21 220 478940 47423 63972149
Poor venous access 29.31 10.21 175 478985 12242 64007330
Cellulitis 29.28 10.21 907 478253 92750 63926822
Dystonia 29.25 10.21 60 479100 18805 64000767
Pemphigoid 29.16 10.21 32 479128 12954 64006618
Dysarthria 29.16 10.21 291 478869 59115 63960457
Dry eye 29.15 10.21 337 478823 28682 63990890
Pulmonary fibrosis 29.14 10.21 345 478815 29533 63990039
C-reactive protein increased 28.85 10.21 916 478244 93993 63925579
Cataract 28.74 10.21 538 478622 50724 63968848
Hallucination, visual 28.64 10.21 108 479052 27726 63991846
Coagulopathy 28.41 10.21 131 479029 31789 63987783
Acute respiratory distress syndrome 28.38 10.21 171 478989 38764 63980808
Tumour lysis syndrome 28.34 10.21 64 479096 19376 64000196
Graft versus host disease in gastrointestinal tract 28.32 10.21 4 479156 5608 64013964
Forced expiratory volume decreased 28.20 10.21 8 479152 6859 64012713
Subdural haematoma 28.13 10.21 110 479050 27944 63991628
Myalgia 28.06 10.21 931 478229 157686 63861886
Surgery 28.05 10.21 327 478833 27886 63991686
No adverse event 28.00 10.21 113 479047 28448 63991124
Erythema multiforme 27.85 10.21 46 479114 15655 64003917
Speech disorder 27.83 10.21 228 478932 48213 63971359
Hypocalcaemia 27.57 10.21 189 478971 41564 63978008
Premature labour 27.53 10.21 121 479039 7499 64012073
Tenosynovitis stenosans 27.49 10.21 51 479109 1909 64017663
Tubulointerstitial nephritis 27.42 10.21 127 479033 30782 63988790
Cytomegalovirus viraemia 27.42 10.21 24 479136 10804 64008768
Mass 27.39 10.21 201 478959 15075 64004497
Pancreatitis acute 27.31 10.21 196 478964 42659 63976913
Septic shock 26.99 10.21 587 478573 104850 63914722
Neoplasm progression 26.76 10.21 186 478974 40778 63978794
Wheelchair user 26.75 10.21 86 479074 4586 64014986
Stress cardiomyopathy 26.65 10.21 18 479142 9239 64010333
Blood alkaline phosphatase increased 26.26 10.21 279 478881 56000 63963572
Acute myeloid leukaemia 26.08 10.21 110 479050 27353 63992219
Blood glucose increased 25.98 10.21 543 478617 97530 63922042
Mania 25.94 10.21 51 479109 16235 64003337
Skin cancer 25.90 10.21 165 478995 11809 64007763
Potentiating drug interaction 25.82 10.21 13 479147 7839 64011733
Fracture delayed union 25.80 10.21 50 479110 1935 64017637
Device use error 25.73 10.21 8 479152 6463 64013109
Exposure to toxic agent 25.62 10.21 7 479153 6152 64013420
Intentional product use issue 25.58 10.21 907 478253 94457 63925115
Skin papilloma 25.57 10.21 91 479069 5112 64014460
Dehydration 25.46 10.21 1333 477827 215430 63804142
Adenovirus infection 25.42 10.21 11 479149 7244 64012328
Wrong technique in product usage process 25.36 10.21 335 478825 64639 63954933
Drug ineffective for unapproved indication 25.26 10.21 132 479028 31001 63988571
Pulmonary embolism 25.19 10.21 862 478298 145494 63874078
Post procedural infection 25.10 10.21 139 479021 9458 64010114
Pleural effusion 25.02 10.21 732 478428 125827 63893745
Cyst 24.96 10.21 164 478996 11863 64007709
Anuria 24.84 10.21 66 479094 18898 64000674
Respiratory depression 24.75 10.21 90 479070 23353 63996219
Acute coronary syndrome 24.70 10.21 68 479092 19242 64000330
Epstein-Barr virus infection 24.65 10.21 34 479126 12454 64007118
Haemoglobin decreased 24.64 10.21 1724 477436 193339 63826233
Chronic graft versus host disease 24.52 10.21 8 479152 6268 64013304
Gastrointestinal haemorrhage 24.50 10.21 772 478388 131540 63888032
Dizziness 24.43 10.21 2810 476350 427353 63592219
Fear 24.36 10.21 73 479087 20098 63999474
Chronic kidney disease 24.33 10.21 294 478866 57625 63961947
Atrial fibrillation 24.30 10.21 1031 478129 170058 63849514
Aphasia 24.20 10.21 191 478969 40715 63978857
Hyperuricaemia 24.14 10.21 24 479136 10167 64009405
Metastases to lung 24.14 10.21 48 479112 15216 64004356
Sinus bradycardia 24.10 10.21 88 479072 22805 63996767
Injection site warmth 24.06 10.21 177 478983 13285 64006287
Joint noise 24.01 10.21 65 479095 3146 64016426
Metastases to liver 23.92 10.21 94 479066 23847 63995725
Nightmare 23.92 10.21 78 479082 20915 63998657
Sepsis 23.85 10.21 1434 477726 228907 63790665
Confusional state 23.76 10.21 1645 477515 259499 63760073
Exostosis 23.75 10.21 156 479004 11282 64008290
Hallucination, auditory 23.70 10.21 57 479103 16882 64002690
Tardive dyskinesia 23.66 10.21 20 479140 9158 64010414
Decreased appetite 23.64 10.21 1784 477376 279505 63740067
Cystitis 23.62 10.21 447 478713 42228 63977344
Rotator cuff repair 23.58 10.21 41 479119 1458 64018114
Drug hypersensitivity 23.50 10.21 1487 477673 236328 63783244
Catatonia 23.05 10.21 14 479146 7606 64011966
Hepatotoxicity 23.00 10.21 188 478972 39774 63979798
Fear of injection 22.99 10.21 96 479064 5816 64013756
Pharyngitis streptococcal 22.98 10.21 126 479034 8542 64011030
Lupus vasculitis 22.96 10.21 23 479137 469 64019103
Malignant melanoma 22.92 10.21 170 478990 12794 64006778
Oliguria 22.91 10.21 46 479114 14530 64005042
Pulmonary oedema 22.83 10.21 429 478731 78245 63941327
Coronary artery disease 22.71 10.21 314 478846 60119 63959453
Nocardiosis 22.69 10.21 4 479156 4763 64014809
Ascites 22.64 10.21 324 478836 61677 63957895
Delusion 22.62 10.21 64 479096 17950 64001622
Haematoma 22.51 10.21 227 478933 46023 63973549
Tuberculosis 22.50 10.21 170 478990 12868 64006704
Victim of child abuse 22.49 10.21 30 479130 841 64018731
Urinary tract infection 22.40 10.21 2005 477155 229591 63789981
Mouth ulceration 22.35 10.21 352 478808 32092 63987480
Infection susceptibility increased 22.24 10.21 57 479103 2669 64016903
Synovial fluid analysis 22.23 10.21 41 479119 1528 64018044
Haemoptysis 22.14 10.21 245 478915 48803 63970769
Cardiac failure acute 22.09 10.21 56 479104 16288 64003284
Pancreatitis 21.94 10.21 311 478849 59296 63960276
Clostridium difficile colitis 21.77 10.21 116 479044 27107 63992465
Cardiac failure chronic 21.75 10.21 21 479139 9020 64010552
Foot operation 21.62 10.21 75 479085 4160 64015412
Rebound effect 21.59 10.21 5 479155 4912 64014660
Glycosylated haemoglobin increased 21.56 10.21 55 479105 15964 64003608
Renal injury 21.53 10.21 52 479108 15377 64004195
Endodontic procedure 21.52 10.21 51 479109 2272 64017300
Cyanosis 21.50 10.21 88 479072 22067 63997505
Haemorrhage 21.41 10.21 438 478722 78913 63940659
Loose body in joint 21.40 10.21 35 479125 1183 64018389
Acute chest syndrome 21.31 10.21 30 479130 886 64018686
Progressive multifocal leukoencephalopathy 21.29 10.21 67 479093 18165 64001407
Hemiplegia 21.20 10.21 39 479121 12729 64006843
Bronchospasm 21.11 10.21 86 479074 21596 63997976
Anxiety 21.08 10.21 1261 477899 201388 63818184
Colitis ulcerative 20.76 10.21 262 478898 22766 63996806
Nephropathy toxic 20.71 10.21 64 479096 17450 64002122
Hepatic cytolysis 20.69 10.21 46 479114 14003 64005569
Endophthalmitis 20.68 10.21 7 479153 5358 64014214
Adverse event 20.62 10.21 410 478750 39079 63980493
Sinus tachycardia 20.61 10.21 147 479013 32041 63987531
Hypoalbuminaemia 20.60 10.21 65 479095 17609 64001963
Generalised tonic-clonic seizure 20.51 10.21 193 478967 39664 63979908
Schizophrenia 20.48 10.21 32 479128 11136 64008436
Transaminases increased 20.43 10.21 222 478938 44372 63975200
Hepatitis cholestatic 20.29 10.21 37 479123 12118 64007454
Cardiotoxicity 20.25 10.21 28 479132 10246 64009326
Cognitive disorder 20.07 10.21 288 478872 54799 63964773
Klebsiella infection 19.96 10.21 43 479117 13238 64006334
Gastrooesophageal reflux disease 19.94 10.21 781 478379 82362 63937210
Foetal death 19.80 10.21 92 479068 5838 64013734
Hepatitis fulminant 19.73 10.21 11 479149 6263 64013309
Ileus paralytic 19.72 10.21 20 479140 8395 64011177
Orthostatic hypotension 19.72 10.21 237 478923 46501 63973071
Cystitis haemorrhagic 19.71 10.21 18 479142 7938 64011634
Cytomegalovirus chorioretinitis 19.66 10.21 6 479154 4906 64014666
Bone marrow failure 19.54 10.21 245 478915 47707 63971865
Maternal exposure timing unspecified 19.45 10.21 54 479106 2653 64016919
Electrocardiogram QRS complex prolonged 19.44 10.21 24 479136 9220 64010352
Ileus 19.41 10.21 96 479064 22870 63996702
Cardiogenic shock 19.38 10.21 151 479009 32276 63987296
Spinal disorder 19.37 10.21 121 479039 8601 64010971
Transplant dysfunction 19.37 10.21 13 479147 6695 64012877
Metastases to bone 19.31 10.21 82 479078 20353 63999219
Hyperlactacidaemia 19.24 10.21 6 479154 4838 64014734
Gastric haemorrhage 19.15 10.21 45 479115 13436 64006136
Haemolysis 19.08 10.21 144 479016 10895 64008677
Tooth disorder 18.98 10.21 252 478908 22150 63997422
Obstructive airways disorder 18.98 10.21 98 479062 23087 63996485
Pruritus 18.97 10.21 2623 476537 309777 63709795
Polyuria 18.94 10.21 41 479119 12602 64006970
Musculoskeletal disorder 18.91 10.21 210 478950 17696 64001876
Haematocrit decreased 18.90 10.21 536 478624 54119 63965453
Mean cell volume increased 18.90 10.21 81 479079 4965 64014607
Leukocytosis 18.88 10.21 184 478976 37556 63982016
Polyhydramnios 18.77 10.21 37 479123 1450 64018122
Urinary retention 18.72 10.21 255 478905 48946 63970626
Persecutory delusion 18.71 10.21 4 479156 4154 64015418
Haemodynamic instability 18.71 10.21 53 479107 14859 64004713
Abdominal pain upper 18.60 10.21 1526 477634 173504 63846068
Body tinea 18.58 10.21 34 479126 1259 64018313
Bradykinesia 18.56 10.21 13 479147 6547 64013025
Hepatocellular carcinoma 18.55 10.21 21 479139 8382 64011190
Intracranial pressure increased 18.30 10.21 15 479145 6974 64012598
Kidney infection 18.29 10.21 208 478952 17630 64001942
Disease recurrence 18.24 10.21 148 479012 31362 63988210
Sudden death 18.16 10.21 82 479078 20014 63999558
Nausea 18.16 10.21 5386 473774 780414 63239158
Blood test abnormal 18.15 10.21 161 478999 12782 64006790
Frequent bowel movements 18.13 10.21 212 478948 18093 64001479
Device difficult to use 18.04 10.21 28 479132 9770 64009802
Antinuclear antibody positive 18.03 10.21 93 479067 6157 64013415
Ulcer 18.01 10.21 255 478905 22735 63996837
Breast feeding 17.99 10.21 24 479136 673 64018899
Myopathy 17.93 10.21 69 479091 17611 64001961
Metastases to central nervous system 17.79 10.21 49 479111 13863 64005709
Pulmonary alveolar haemorrhage 17.77 10.21 28 479132 9710 64009862
Eye infection 17.73 10.21 124 479036 9157 64010415
Synovial disorder 17.69 10.21 28 479132 920 64018652
Atrioventricular block complete 17.54 10.21 52 479108 14366 64005206
Stillbirth 17.40 10.21 63 479097 3570 64016002
Affective disorder 17.38 10.21 14 479146 6566 64013006
Graft versus host disease in skin 17.36 10.21 9 479151 5338 64014234
Therapeutic response decreased 17.27 10.21 509 478651 51679 63967893
Osteopenia 17.22 10.21 184 478976 15356 64004216
Induced labour 17.20 10.21 26 479134 820 64018752
Sciatica 17.19 10.21 228 478932 20036 63999536
Hyperthyroidism 17.15 10.21 73 479087 18106 64001466
Muscle swelling 17.12 10.21 24 479136 706 64018866
Acidosis 17.07 10.21 71 479089 17724 64001848
Lip swelling 17.06 10.21 153 479007 31754 63987818
Blood lactic acid increased 17.06 10.21 32 479128 10369 64009203
Pneumonia bacterial 17.04 10.21 56 479104 14979 64004593
Acute myocardial infarction 17.03 10.21 391 478769 69327 63950245
Aplasia 16.90 10.21 16 479144 6937 64012635
Postoperative wound infection 16.85 10.21 133 479027 10203 64009369
Impaired work ability 16.77 10.21 180 478980 15039 64004533
Lipase increased 16.77 10.21 53 479107 14349 64005223
Aspartate aminotransferase increased 16.76 10.21 723 478437 119065 63900507
Tooth infection 16.70 10.21 174 478986 14427 64005145
Withdrawal syndrome 16.69 10.21 104 479056 23388 63996184
Myelosuppression 16.67 10.21 106 479054 23724 63995848
Pulmonary hypertension 16.62 10.21 223 478937 42916 63976656
Coronary arterial stent insertion 16.48 10.21 11 479149 5681 64013891
Spinal osteoarthritis 16.45 10.21 171 478989 14170 64005402
Scleritis 16.44 10.21 54 479106 2912 64016660
Diabetes mellitus inadequate control 16.42 10.21 92 479068 21229 63998343
Atrioventricular block 16.37 10.21 41 479119 11974 64007598
Haematemesis 16.33 10.21 248 478912 46751 63972821
Platelet count decreased 16.32 10.21 1050 478110 166661 63852911
Nephrectomy 16.31 10.21 34 479126 1388 64018184
Muscle twitching 16.30 10.21 79 479081 18919 64000653
Bradypnoea 16.29 10.21 9 479151 5150 64014422
Blood parathyroid hormone decreased 16.24 10.21 102 479058 7264 64012308
Hyperprolactinaemia 16.21 10.21 5 479155 4060 64015512
Bone density decreased 16.19 10.21 128 479032 9824 64009748
Increased tendency to bruise 16.15 10.21 121 479039 9134 64010438
Hiatus hernia 15.89 10.21 222 478938 19735 63999837
Hypophosphataemia 15.88 10.21 56 479104 14664 64004908
Kidney transplant rejection 15.83 10.21 29 479131 9482 64010090
Immunosuppression 15.76 10.21 135 479025 10611 64008961
Ventricular fibrillation 15.75 10.21 108 479052 23752 63995820
Myocarditis 15.73 10.21 69 479091 16974 64002598
Diabetes insipidus 15.61 10.21 7 479153 4514 64015058
Sexual dysfunction 15.60 10.21 15 479145 6456 64013116
Medication error 15.58 10.21 269 478891 49697 63969875
Foetal distress syndrome 15.58 10.21 18 479142 434 64019138
Cartilage injury 15.34 10.21 32 479128 1307 64018265
Pulmonary congestion 15.32 10.21 109 479051 23771 63995801
Dysphagia 15.30 10.21 643 478517 106169 63913403
Parkinsonism 15.29 10.21 55 479105 14318 64005254
Angina pectoris 15.28 10.21 239 478921 44842 63974730
Pneumatosis intestinalis 15.28 10.21 10 479150 5219 64014353
Dactylitis 15.27 10.21 40 479120 1898 64017674
Granuloma skin 15.24 10.21 87 479073 5987 64013585
Accidental exposure to product 15.18 10.21 124 479036 26240 63993332
Wound infection 15.10 10.21 173 478987 14691 64004881
Oxygen saturation decreased 15.09 10.21 956 478204 106220 63913352
Hepatitis acute 15.08 10.21 50 479110 13339 64006233
Enterocolitis 14.87 10.21 43 479117 11975 64007597
Cestode infection 14.86 10.21 14 479146 264 64019308
Joint dislocation 14.75 10.21 140 479020 11325 64008247
Respiratory acidosis 14.73 10.21 32 479128 9823 64009749
Dermatitis acneiform 14.73 10.21 25 479135 8418 64011154
Ingrown hair 14.69 10.21 20 479140 572 64019000
Hepatitis C 14.68 10.21 38 479122 10977 64008595
Cytopenia 14.67 10.21 62 479098 15409 64004163
Wound infection pseudomonas 14.58 10.21 34 479126 1499 64018073
Blood folate increased 14.56 10.21 18 479142 467 64019105
Alcohol abuse 14.56 10.21 9 479151 4843 64014729
Drug abuser 14.55 10.21 13 479147 5795 64013777
Personality change 14.48 10.21 26 479134 8567 64011005
Presyncope 14.40 10.21 179 478981 34910 63984662
Skin infection 14.38 10.21 173 478987 14864 64004708
Lacrimal disorder 14.38 10.21 18 479142 473 64019099
Nephrotic syndrome 14.35 10.21 31 479129 9536 64010036
Joint lock 14.33 10.21 50 479110 2781 64016791
Encephalitis toxic 14.32 10.21 14 479146 277 64019295
Acute pulmonary oedema 14.31 10.21 48 479112 12761 64006811
Virologic failure 14.30 10.21 4 479156 3462 64016110
Dermatitis bullous 14.29 10.21 44 479116 12010 64007562
Acute lymphocytic leukaemia recurrent 14.27 10.21 6 479154 4020 64015552
Cerebrovascular accident 14.15 10.21 857 478303 136726 63882846
Drug screen positive 14.14 10.21 13 479147 5716 64013856
Injection site urticaria 14.12 10.21 136 479024 11045 64008527
Human antichimeric antibody positive 14.12 10.21 32 479128 1384 64018188
Accidental death 14.12 10.21 5 479155 3720 64015852
Ataxia 14.07 10.21 101 479059 21983 63997589
Knee operation 13.99 10.21 69 479091 4488 64015084
Haemorrhage in pregnancy 13.98 10.21 30 479130 1250 64018322
Placental disorder 13.95 10.21 24 479136 846 64018726
Skin laceration 13.94 10.21 257 478903 24160 63995412
Jaundice cholestatic 13.94 10.21 27 479133 8643 64010929
Peripheral sensory neuropathy 13.87 10.21 41 479119 11337 64008235
Hemiparesis 13.86 10.21 148 479012 29679 63989893
Vertigo 13.84 10.21 333 478827 58678 63960894
Cervical incompetence 13.78 10.21 18 479142 494 64019078
Right ventricular failure 13.77 10.21 98 479062 21373 63998199
Oxalosis 13.64 10.21 9 479151 98 64019474
Catheter management 13.61 10.21 4 479156 3351 64016221
Lymphadenitis 13.59 10.21 60 479100 3725 64015847
Deafness transitory 13.59 10.21 23 479137 800 64018772
Gestational hypertension 13.56 10.21 35 479125 1646 64017926
Myocardial ischaemia 13.55 10.21 109 479051 23142 63996430
Bone density abnormal 13.48 10.21 48 479112 2697 64016875
Polydipsia 13.46 10.21 14 479146 5807 64013765
Heart rate irregular 13.45 10.21 282 478878 27131 63992441
Incoherent 13.44 10.21 20 479140 7098 64012474
Alcohol interaction 13.43 10.21 8 479152 4393 64015179
Acute graft versus host disease in intestine 13.42 10.21 5 479155 3604 64015968
Pulmonary haemorrhage 13.40 10.21 51 479109 13058 64006514
Pulseless electrical activity 13.39 10.21 49 479111 12690 64006882
Nephrolithiasis 13.37 10.21 422 478738 43261 63976311
Iodine allergy 13.35 10.21 18 479142 510 64019062
Immune thrombocytopenia 13.31 10.21 62 479098 15004 64004568
Pharyngitis 13.28 10.21 207 478953 18832 64000740
Emotional distress 13.27 10.21 188 478972 35850 63983722
Liver transplant rejection 13.27 10.21 3 479157 2996 64016576
Capillary leak syndrome 13.25 10.21 4 479156 3293 64016279
Hypotonia 13.24 10.21 41 479119 11171 64008401
Hypercapnia 13.22 10.21 23 479137 7671 64011901
Psychomotor skills impaired 13.20 10.21 6 479154 3839 64015733
Therapy partial responder 13.17 10.21 36 479124 10212 64009360
Tooth fracture 13.16 10.21 122 479038 9805 64009767
Heparin-induced thrombocytopenia 13.12 10.21 27 479133 8452 64011120
Intestinal ischaemia 13.10 10.21 43 479117 11506 64008066
Genital haemorrhage 13.08 10.21 13 479147 5509 64014063
Acute respiratory failure 13.06 10.21 277 478883 49657 63969915
Toothache 13.02 10.21 192 478968 17267 64002305
Intervertebral disc degeneration 13.01 10.21 152 479008 12968 64006604
Toxic encephalopathy 12.98 10.21 34 479126 9781 64009791
Arthropod bite 12.96 10.21 90 479070 6631 64012941
Sickle cell anaemia 12.96 10.21 19 479141 583 64018989
Ventricular arrhythmia 12.89 10.21 22 479138 7393 64012179
Body height below normal 12.80 10.21 36 479124 1782 64017790
Dyspnoea at rest 12.73 10.21 17 479143 6312 64013260
Small for dates baby 12.71 10.21 16 479144 423 64019149
Multiple sclerosis relapse 12.65 10.21 222 478938 40913 63978659
Hypoxic-ischaemic encephalopathy 12.64 10.21 21 479139 7131 64012441
End stage renal disease 12.58 10.21 38 479122 10437 64009135
Multiple-drug resistance 12.54 10.21 18 479142 6484 64013088
Burning sensation 12.49 10.21 469 478691 49195 63970377
Compartment syndrome 12.49 10.21 8 479152 4224 64015348
Amylase increased 12.47 10.21 34 479126 9651 64009921
Magnesium deficiency 12.45 10.21 18 479142 545 64019027
Lupus nephritis 12.44 10.21 43 479117 2381 64017191
Laryngospasm 12.43 10.21 5 479155 3440 64016132
Placental insufficiency 12.42 10.21 25 479135 995 64018577
Cholangitis 12.40 10.21 40 479120 10762 64008810
Skin texture abnormal 12.35 10.21 15 479145 382 64019190
Coronary artery bypass 12.33 10.21 15 479145 5800 64013772
Tooth abscess 12.33 10.21 157 479003 13669 64005903
Wrist fracture 12.31 10.21 121 479039 9880 64009692
Arthritis bacterial 12.31 10.21 100 479060 7739 64011833
Lymphatic fistula 12.27 10.21 21 479139 737 64018835
Ketoacidosis 12.27 10.21 20 479140 6843 64012729
Hepatic siderosis 12.27 10.21 10 479150 154 64019418
Limb injury 12.26 10.21 244 478916 23261 63996311
Pulmonary tuberculosis 12.24 10.21 94 479066 7150 64012422
Panniculitis 12.22 10.21 110 479050 8769 64010803
Femoral hernia incarcerated 12.21 10.21 21 479139 740 64018832
Labyrinthitis 12.15 10.21 45 479115 2578 64016994
Metastases to meninges 12.09 10.21 3 479157 2812 64016760
Injection site extravasation 12.08 10.21 102 479058 7984 64011588
Tuberculin test positive 12.07 10.21 50 479110 3018 64016554
Colitis microscopic 12.07 10.21 23 479137 7409 64012163
Oedema 12.02 10.21 559 478601 91376 63928196
Epilepsy 11.97 10.21 176 478984 33355 63986217
Strongyloidiasis 11.97 10.21 4 479156 3086 64016486
Cross sensitivity reaction 11.96 10.21 5 479155 3362 64016210
Disturbance in social behaviour 11.96 10.21 7 479153 3880 64015692
Cushingoid 11.94 10.21 97 479063 7506 64012066
Deep vein thrombosis 11.93 10.21 649 478511 104533 63915039
Paralysis 11.92 10.21 45 479115 11550 64008022
Incorrect route of product administration 11.91 10.21 113 479047 23185 63996387
Normal newborn 11.90 10.21 77 479083 5540 64014032
Pain in jaw 11.89 10.21 222 478938 40533 63979039
Abortion threatened 11.87 10.21 15 479145 398 64019174
Bone pain 11.84 10.21 266 478894 47306 63972266
Linear IgA disease 11.83 10.21 3 479157 2771 64016801
Lung hernia 11.81 10.21 7 479153 62 64019510
Chest pain 11.80 10.21 1554 477606 234426 63785146
Abortion incomplete 11.79 10.21 4 479156 3057 64016515
Malignant mediastinal neoplasm 11.71 10.21 17 479143 517 64019055
Hepatitis B 11.70 10.21 25 479135 7720 64011852
Visual acuity reduced 11.69 10.21 137 479023 27004 63992568
Dislocation of vertebra 11.59 10.21 50 479110 3074 64016498
Acute lung injury 11.56 10.21 3 479157 2728 64016844
Finger deformity 11.55 10.21 72 479088 5114 64014458
Pneumothorax 11.52 10.21 120 479040 24178 63995394
Drug specific antibody 11.49 10.21 38 479122 2057 64017515
Chondropathy 11.47 10.21 41 479119 2308 64017264
Hypernatraemia 11.46 10.21 49 479111 12140 64007432
Lower respiratory tract congestion 11.45 10.21 48 479112 2913 64016659
Blood iron increased 11.45 10.21 29 479131 1348 64018224
Maternal exposure during breast feeding 11.44 10.21 37 479123 1979 64017593
Hypoglycaemic coma 11.41 10.21 9 479151 4265 64015307
Hyperhidrosis 11.33 10.21 787 478373 124133 63895439
Aphthous ulcer 11.28 10.21 146 479014 12760 64006812
Lymphopenia 11.25 10.21 129 479031 25528 63994044
Lymphadenectomy 11.25 10.21 24 479136 996 64018576
Product substitution issue 11.23 10.21 82 479078 17779 64001793
Neck pain 11.21 10.21 562 478598 60971 63958601
Osteonecrosis 11.21 10.21 145 479015 28084 63991488
Hypertriglyceridaemia 11.19 10.21 44 479116 11161 64008411
Oesophageal fibrosis 11.17 10.21 10 479150 176 64019396
Vascular rupture 11.16 10.21 28 479132 1294 64018278
Generalised oedema 11.15 10.21 100 479060 20753 63998819
Palindromic rheumatism 11.14 10.21 13 479147 317 64019255
Erectile dysfunction 11.13 10.21 52 479108 12575 64006997
Renal tubular disorder 11.13 10.21 17 479143 5970 64013602
Inadequate analgesia 11.10 10.21 8 479152 3970 64015602
Faecal calprotectin increased 11.09 10.21 55 479105 3585 64015987
Diabetes mellitus 11.09 10.21 393 478767 66081 63953491
Granulocytopenia 11.07 10.21 40 479120 10400 64009172
International normalised ratio increased 11.04 10.21 478 478682 78689 63940883
Anti-neutrophil cytoplasmic antibody positive vasculitis 11.03 10.21 4 479156 2932 64016640
Hernia 11.02 10.21 151 479009 13367 64006205
Uterine contractions during pregnancy 11.01 10.21 14 479146 374 64019198
Human anti-human antibody test 11.01 10.21 14 479146 374 64019198
Peritoneal dialysis complication 10.98 10.21 39 479121 2189 64017383
Human herpesvirus 6 infection 10.98 10.21 11 479149 4643 64014929
Threatened labour 10.98 10.21 17 479143 548 64019024
Breast abscess 10.93 10.21 25 479135 1088 64018484
Joint warmth 10.93 10.21 29 479131 1387 64018185
Nasal congestion 10.90 10.21 545 478615 59113 63960459
Sinus congestion 10.82 10.21 168 478992 15271 64004301
Pseudomonas infection 10.81 10.21 83 479077 17800 64001772
Ankle arthroplasty 10.79 10.21 22 479138 884 64018688
Dermatitis exfoliative 10.76 10.21 40 479120 10312 64009260
Metastasis 10.75 10.21 16 479144 5679 64013893
Meniscus injury 10.75 10.21 78 479082 5829 64013743
Respiration abnormal 10.74 10.21 19 479141 6296 64013276
Skin abrasion 10.71 10.21 133 479027 11512 64008060
Blood pressure decreased 10.70 10.21 527 478633 85672 63933900
Serum ferritin increased 10.69 10.21 103 479057 8365 64011207
Lip blister 10.67 10.21 39 479121 2220 64017352
Electrolyte imbalance 10.65 10.21 128 479032 25115 63994457
Lupus-like syndrome 10.65 10.21 106 479054 8685 64010887
Anhedonia 10.63 10.21 59 479101 13647 64005925
Clear cell renal cell carcinoma 10.62 10.21 38 479122 2141 64017431
Neutropenic colitis 10.61 10.21 11 479149 4570 64015002
Salivary hypersecretion 10.61 10.21 50 479110 12063 64007509
Stress at work 10.59 10.21 23 479137 966 64018606
Left ventricular dysfunction 10.58 10.21 78 479082 16876 64002696
Areflexia 10.53 10.21 13 479147 4994 64014578
Cogwheel rigidity 10.53 10.21 4 479156 2849 64016723
Complications of transplanted kidney 10.52 10.21 15 479145 5420 64014152
Device related infection 10.50 10.21 162 478998 30464 63989108
Cholestasis of pregnancy 10.47 10.21 22 479138 903 64018669
Vascular purpura 10.45 10.21 3 479157 2553 64017019
Liver transplant 10.45 10.21 9 479151 4083 64015489
Haematuria 10.43 10.21 356 478804 60115 63959457
Adjustment disorder with depressed mood 10.43 10.21 41 479119 2416 64017156
Oedema peripheral 10.39 10.21 1386 477774 208931 63810641
Nodal osteoarthritis 10.38 10.21 17 479143 575 64018997
Plantar fasciitis 10.35 10.21 45 479115 2775 64016797
Paranoia 10.31 10.21 75 479085 16277 64003295
Delivery 10.30 10.21 16 479144 517 64019055
Cell death 10.25 10.21 9 479151 4045 64015527
Musculoskeletal discomfort 10.25 10.21 174 478986 16103 64003469

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11GA01 ALIMENTARY TRACT AND METABOLISM
VITAMINS
ASCORBIC ACID (VITAMIN C), INCL. COMBINATIONS
Ascorbic acid (vitamin C), plain
ATC A11GB01 ALIMENTARY TRACT AND METABOLISM
VITAMINS
ASCORBIC ACID (VITAMIN C), INCL. COMBINATIONS
Ascorbic acid (vitamin C), combinations
ATC G01AD03 GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Organic acids
ATC S01XA15 SENSORY ORGANS
OPHTHALMOLOGICALS
OTHER OPHTHALMOLOGICALS
Other ophthalmologicals
FDA CS M0001797 Ascorbic Acid
MeSH PA D000975 Antioxidants
MeSH PA D018977 Micronutrients
MeSH PA D020011 Protective Agents
MeSH PA D014815 Vitamins
FDA EPC N0000193618 Vitamin C
CHEBI has role CHEBI:23354 coenzymes
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:64577 dough improvers
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:77962 food antioxidants
CHEBI has role CHEBI:85046 skin lightening agents
CHEBI has role CHEBI:176497 geroprotectors
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:83056 Daphnia magna metabolites
CHEBI has role CHEBI:63247 reducer
CHEBI has role CHEBI:27314 water-soluble vitamins

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Ascorbic acid deficiency indication 76169001
Breastfeeding (mother) indication 413712001
Coronavirus infection off-label use 186747009
Anuria contraindication 2472002 DOID:2983
Hypocalcemia contraindication 5291005
Peptic ulcer contraindication 13200003 DOID:750
Hyperkalemia contraindication 14140009
Severe chronic ulcerative colitis contraindication 14311001
Constipation contraindication 14760008 DOID:2089
Operation on stomach contraindication 16453004
Primary hyperoxaluria contraindication 17901006 DOID:2977
Hypocupremia contraindication 19577007
Hyperphosphatemia contraindication 20165001 DOID:0050459
Sunburn contraindication 23346002
Acute vomiting contraindication 23971007
Multiple sclerosis contraindication 24700007 DOID:2377
Gastroenteritis contraindication 25374005 DOID:2326
Acute tuberculosis contraindication 25629007
Hypervitaminosis D contraindication 27712000 DOID:9971
Complete atrioventricular block contraindication 27885002
Toxic megacolon contraindication 28536002 DOID:1770
Dental fluorosis contraindication 30265004
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Hypertensive disorder contraindication 38341003 DOID:10763
Hemosiderosis contraindication 39011001 DOID:12119
Gastrointestinal ulcer contraindication 40845000
Toxic colitis contraindication 42359007
Hypokalemia contraindication 43339004
Gastrointestinal perforation contraindication 51875005
Gastrectomy contraindication 53442002
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Hyperlipidemia contraindication 55822004 DOID:1168
Congenital myotonia, autosomal dominant form contraindication 57938005
Acute nephropathy contraindication 58574008
Leber's optic atrophy contraindication 58610003 DOID:705
Hemolytic anemia contraindication 61261009 DOID:583
Allergic rhinitis contraindication 61582004
Hypervitaminosis A contraindication 64559002 DOID:9972
Ulcerative colitis contraindication 64766004 DOID:8577
Blood coagulation disorder contraindication 64779008 DOID:1247
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Rheumatoid arthritis contraindication 69896004 DOID:7148
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperchloremia contraindication 74450001
Third degree burn injury contraindication 80247002
Intestinal obstruction contraindication 81060008 DOID:8437
Atrophic gastritis contraindication 84568007 DOID:8929
Human immunodeficiency virus infection contraindication 86406008 DOID:526
Wilson's disease contraindication 88518009
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:557
Leukemia, disease contraindication 93143009 DOID:1240
Kidney stone contraindication 95570007
Anemia due to enzyme deficiency contraindication 111577008
Gastrointestinal obstruction contraindication 126765001
Hb SS disease contraindication 127040003 DOID:10923
Seizure disorder contraindication 128613002
Osteolysis contraindication 203522001
Disease of liver contraindication 235856003 DOID:409
Hyporeninemic hypoaldosteronism contraindication 236464008
Esophageal dysmotility contraindication 266434009 DOID:9192
Familial hyperkalemic periodic paralysis contraindication 304737009 DOID:14451
Gastric retention contraindication 307227006
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
At risk for aspiration contraindication 371736008
Diverticular disease contraindication 397881000
Hemochromatosis contraindication 399187006 DOID:2352
Denuded skin contraindication 418242004
Severe dehydration contraindication 450316000
Acute exacerbation of asthma contraindication 708038006
Vitamin K Deficiency Induced Hypoprothrombinemia contraindication
Malabsorption States contraindication
Repeated Blood Transfusions contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.02 acidic
pKa2 9.62 acidic
pKa3 11.85 acidic
pKa4 12.53 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM PLENVU SALIX N209381 May 4, 2018 RX FOR SOLUTION ORAL 10792306 March 9, 2032 FOR CLEANSING OF THE COLON IN PREPARATION FOR COLONOSCOPY IN ADULTS
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM PLENVU SALIX N209381 May 4, 2018 RX FOR SOLUTION ORAL 9592252 Aug. 11, 2032 FOR CLEANSING OF THE COLON IN PREPARATION FOR COLONOSCOPY IN ADULTS
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM PLENVU SALIX N209381 May 4, 2018 RX FOR SOLUTION ORAL 10918723 Sept. 10, 2033 FOR CLEANSING OF THE COLON IN PREPARATION FOR COLONOSCOPY IN ADULTS
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM PLENVU SALIX N209381 May 4, 2018 RX FOR SOLUTION ORAL 9326969 Sept. 10, 2033 FOR CLEANSING OF THE COLON IN PREPARATION FOR COLONOSCOPY IN ADULTS

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
25,000MG/50ML (500MG/ML) ASCOR MCGUFF N209112 Oct. 2, 2017 RX SOLUTION INTRAVENOUS Oct. 2, 2024 FOR TREATMENT OF SCURVY IN ADULT AND PEDIATRIC PATIENTS AGE 5 MONTHS AND OLDER FOR WHOM ORAL ADMINISTRATION IS NOT POSSIBLE, INSUFFICIENT OR CONTRAINDICATED

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Tyrosinase Enzyme IC50 4.49 CHEMBL
Prolyl 4-hydroxylase subunit alpha-1 Enzyme WOMBAT-PK
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 Enzyme WOMBAT-PK
Solute carrier family 23 member 2 Transporter WOMBAT-PK
Solute carrier family 23 member 1 Transporter WOMBAT-PK
Pancreatic alpha-amylase Enzyme IC50 4.58 CHEMBL

External reference:

IDSource
4017646 VUID
N0000146025 NUI
D00018 KEGG_DRUG
134-03-2 SECONDARY_CAS_RN
5743-28-2 SECONDARY_CAS_RN
4017471 VANDF
4017472 VANDF
4017646 VANDF
4021716 VANDF
4026966 VANDF
C0003968 UMLSCUI
CHEBI:29073 CHEBI
ASC PDB_CHEM_ID
CHEMBL196 ChEMBL_ID
CHEMBL591665 ChEMBL_ID
CHEMBL2146095 ChEMBL_ID
D001205 MESH_DESCRIPTOR_UI
DB00126 DRUGBANK_ID
C069207 MESH_SUPPLEMENTAL_RECORD_UI
4781 IUPHAR_LIGAND_ID
372 INN_ID
PQ6CK8PD0R UNII
54670067 PUBCHEM_CID
DB14482 DRUGBANK_ID
DB14483 DRUGBANK_ID
1151 RXNORM
1132 MMSL
32646 MMSL
4221 MMSL
5471 MMSL
5687 MMSL
6032 MMSL
72299 MMSL
NOCODE MMSL
d00426 MMSL
001010 NDDF
001011 NDDF
001012 NDDF
126230002 SNOMEDCT_US
126231003 SNOMEDCT_US
43706004 SNOMEDCT_US
46123006 SNOMEDCT_US
174 INN_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ferralet 90 HUMAN PRESCRIPTION DRUG LABEL 5 0178-0089 TABLET, FILM COATED 120 mg ORAL unapproved drug other 17 sections
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 120 mg ORAL Unapproved drug other 12 sections
CitraNatal Bloom HUMAN PRESCRIPTION DRUG LABEL 6 0178-0813 TABLET, FILM COATED 138 mg ORAL unapproved drug other 15 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 120 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 120 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 120 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 120 mg ORAL Unapproved drug other 9 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 120 mg ORAL Unapproved drug other 11 sections
Antiflu Kids HUMAN OTC DRUG LABEL 3 0280-0046 POWDER, FOR SOLUTION 50 mg ORAL Export only 2 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 30 mg ORAL unapproved drug other 14 sections
Vitafol Caplet HUMAN PRESCRIPTION DRUG LABEL 12 0642-0072 CAPSULE 60 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 60 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol OB Caplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 70 mg ORAL Unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 12 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 30 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 60 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Strovite Forte Caplet HUMAN PRESCRIPTION DRUG LABEL 19 0642-0204 TABLET, COATED 500 mg ORAL UNAPPROVED DRUG OTHER 15 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 300 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 16 0642-3010 CAPSULE, GELATIN COATED 30 mg ORAL unapproved drug other 7 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 60 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 100 mg ORAL UNAPPROVED DRUG OTHER 4 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 500 mg ORAL UNAPPROVED DRUG OTHER 10 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 16 0813-0202 TABLET 70 mg ORAL UNAPPROVED DRUG OTHER 6 sections
Acetaminophen, Ascorbic acid, Chlorpheniramine Maleate HUMAN OTC DRUG LABEL 3 10267-2949 POWDER, FOR SOLUTION 50 mg ORAL Export only 1 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 100 mg ORAL Unapproved drug other 7 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 9 10542-010 TABLET, COATED 100 mg ORAL Unapproved drug other 7 sections
Dialyvite 5000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-011 TABLET, COATED 100 mg ORAL Unapproved drug other 7 sections
Dialyvite with Zinc HUMAN PRESCRIPTION DRUG LABEL 10 10542-012 TABLET, COATED 100 mg ORAL Unapproved drug other 7 sections
Dialyvite 3000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-014 TABLET, COATED 100 mg ORAL Unapproved drug other 7 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 10544-549 TABLET, FILM COATED 120 mg ORAL unapproved drug other 8 sections