Stem definition | Drug id | CAS RN |
---|---|---|
282 | 1134-47-0 |
Dose | Unit | Route |
---|---|---|
50 | mg | O |
0.55 | mg | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 2.10 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 69 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 6.22 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 90 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.65 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 1.70 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.69 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 5.24 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Nov. 22, 1977 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Multiple sclerosis relapse | 1684.50 | 10.28 | 1021 | 101424 | 47457 | 63339120 |
Multiple sclerosis | 1067.70 | 10.28 | 597 | 101848 | 23775 | 63362802 |
Drug withdrawal syndrome | 983.35 | 10.28 | 588 | 101857 | 26606 | 63359971 |
Muscle spasticity | 613.24 | 10.28 | 402 | 102043 | 21392 | 63365185 |
Coma | 451.71 | 10.28 | 538 | 101907 | 63826 | 63322751 |
Implant site extravasation | 446.55 | 10.28 | 113 | 102332 | 386 | 63386191 |
Implant site infection | 440.49 | 10.28 | 130 | 102315 | 884 | 63385693 |
Urinary tract infection | 358.63 | 10.28 | 1088 | 101357 | 263596 | 63122981 |
Somnolence | 333.12 | 10.28 | 826 | 101619 | 177859 | 63208718 |
Gait disturbance | 328.12 | 10.28 | 834 | 101611 | 182344 | 63204233 |
Seizure | 290.40 | 10.28 | 653 | 101792 | 131981 | 63254596 |
Completed suicide | 285.87 | 10.28 | 687 | 101758 | 144986 | 63241591 |
Fall | 277.23 | 10.28 | 1309 | 101136 | 391025 | 62995552 |
Pneumonia aspiration | 276.29 | 10.28 | 309 | 102136 | 34231 | 63352346 |
Cerebrospinal fluid leakage | 262.08 | 10.28 | 91 | 102354 | 1099 | 63385478 |
Glossodynia | 245.39 | 10.28 | 10 | 102435 | 178866 | 63207711 |
Muscular weakness | 244.27 | 10.28 | 581 | 101864 | 121772 | 63264805 |
Hypotonia | 241.15 | 10.28 | 163 | 102282 | 9122 | 63377455 |
Muscle spasms | 238.08 | 10.28 | 670 | 101775 | 155480 | 63231097 |
Overdose | 211.09 | 10.28 | 529 | 101916 | 114549 | 63272028 |
Systemic lupus erythematosus | 199.90 | 10.28 | 46 | 102399 | 208872 | 63177705 |
Pericarditis | 196.75 | 10.28 | 3 | 102442 | 131576 | 63255001 |
Unresponsive to stimuli | 189.86 | 10.28 | 253 | 102192 | 33563 | 63353014 |
Mental status changes | 189.02 | 10.28 | 274 | 102171 | 39325 | 63347252 |
Hypertonia | 182.53 | 10.28 | 106 | 102339 | 4531 | 63382046 |
Hand deformity | 179.03 | 10.28 | 23 | 102422 | 159434 | 63227143 |
Device failure | 174.21 | 10.28 | 113 | 102332 | 5898 | 63380679 |
Joint swelling | 171.06 | 10.28 | 166 | 102279 | 327500 | 63059077 |
Contraindicated product administered | 168.68 | 10.28 | 70 | 102375 | 217578 | 63168999 |
Arthropathy | 162.81 | 10.28 | 88 | 102357 | 234704 | 63151873 |
Synovitis | 156.75 | 10.28 | 53 | 102392 | 186865 | 63199712 |
Device infusion issue | 156.62 | 10.28 | 73 | 102372 | 1965 | 63384612 |
Infusion related reaction | 149.51 | 10.28 | 107 | 102338 | 245414 | 63141163 |
Abdominal discomfort | 148.15 | 10.28 | 180 | 102265 | 320705 | 63065872 |
Implant site erosion | 146.58 | 10.28 | 33 | 102412 | 56 | 63386521 |
White blood cell count abnormal | 144.27 | 10.28 | 102 | 102343 | 6140 | 63380437 |
Helicobacter infection | 135.09 | 10.28 | 3 | 102442 | 92782 | 63293795 |
Rash | 130.65 | 10.28 | 466 | 101979 | 560405 | 62826172 |
Maternal exposure during pregnancy | 129.96 | 10.28 | 99 | 102346 | 219963 | 63166614 |
Febrile neutropenia | 128.41 | 10.28 | 19 | 102426 | 118430 | 63268147 |
Balance disorder | 127.30 | 10.28 | 361 | 102084 | 84061 | 63302516 |
Wound | 127.28 | 10.28 | 52 | 102393 | 163211 | 63223366 |
Medical device site pain | 126.23 | 10.28 | 34 | 102411 | 157 | 63386420 |
Central nervous system lesion | 124.80 | 10.28 | 117 | 102328 | 10518 | 63376059 |
Drug intolerance | 123.49 | 10.28 | 192 | 102253 | 308469 | 63078108 |
Muscle tightness | 122.83 | 10.28 | 122 | 102323 | 11778 | 63374799 |
Lymphocyte count decreased | 119.83 | 10.28 | 192 | 102253 | 30065 | 63356512 |
Hypoaesthesia | 119.29 | 10.28 | 563 | 101882 | 167830 | 63218747 |
Secondary progressive multiple sclerosis | 118.68 | 10.28 | 54 | 102391 | 1373 | 63385204 |
Decubitus ulcer | 110.71 | 10.28 | 109 | 102336 | 10411 | 63376166 |
Memory impairment | 110.64 | 10.28 | 395 | 102050 | 103863 | 63282714 |
Anaemia | 108.56 | 10.28 | 192 | 102253 | 293238 | 63093339 |
Swelling | 108.51 | 10.28 | 173 | 102272 | 275205 | 63111372 |
Exposure during pregnancy | 108.20 | 10.28 | 58 | 102387 | 155489 | 63231088 |
Influenza like illness | 107.89 | 10.28 | 293 | 102152 | 66531 | 63320046 |
Complication associated with device | 107.76 | 10.28 | 135 | 102310 | 16843 | 63369734 |
Device physical property issue | 103.90 | 10.28 | 55 | 102390 | 1957 | 63384620 |
Toxicity to various agents | 103.36 | 10.28 | 718 | 101727 | 246532 | 63140045 |
Product use issue | 102.44 | 10.28 | 123 | 102322 | 220397 | 63166180 |
Withdrawal syndrome | 102.23 | 10.28 | 143 | 102302 | 19854 | 63366723 |
Diarrhoea | 99.74 | 10.28 | 711 | 101734 | 714655 | 62671922 |
Drug ineffective | 99.72 | 10.28 | 1144 | 101301 | 1043621 | 62342956 |
Medical device site infection | 99.05 | 10.28 | 31 | 102414 | 263 | 63386314 |
Progressive multiple sclerosis | 96.15 | 10.28 | 44 | 102401 | 1134 | 63385443 |
Tremor | 94.98 | 10.28 | 444 | 102001 | 131795 | 63254782 |
Therapeutic product effect decreased | 92.68 | 10.28 | 105 | 102340 | 193082 | 63193495 |
Urine analysis abnormal | 89.13 | 10.28 | 70 | 102375 | 4946 | 63381631 |
Device power source issue | 88.81 | 10.28 | 34 | 102411 | 551 | 63386026 |
Folliculitis | 87.02 | 10.28 | 7 | 102438 | 70310 | 63316267 |
Implant site discharge | 85.63 | 10.28 | 24 | 102421 | 132 | 63386445 |
Muscle injury | 85.25 | 10.28 | 5 | 102440 | 65340 | 63321237 |
Toxic encephalopathy | 84.23 | 10.28 | 76 | 102369 | 6503 | 63380074 |
Post lumbar puncture syndrome | 83.58 | 10.28 | 33 | 102412 | 583 | 63385994 |
Malignant neoplasm progression | 82.75 | 10.28 | 16 | 102429 | 82105 | 63304472 |
Implant site swelling | 82.32 | 10.28 | 31 | 102414 | 479 | 63386098 |
Alopecia | 81.39 | 10.28 | 276 | 102169 | 337260 | 63049317 |
Device kink | 80.96 | 10.28 | 47 | 102398 | 2007 | 63384570 |
Urinary incontinence | 80.67 | 10.28 | 167 | 102278 | 31847 | 63354730 |
Progressive multifocal leukoencephalopathy | 80.51 | 10.28 | 102 | 102343 | 12869 | 63373708 |
Discomfort | 80.24 | 10.28 | 91 | 102354 | 167283 | 63219294 |
Gastrooesophageal reflux disease | 76.82 | 10.28 | 332 | 102113 | 95307 | 63291270 |
Encephalopathy | 74.38 | 10.28 | 181 | 102264 | 38439 | 63348138 |
Medical device site discharge | 73.95 | 10.28 | 16 | 102429 | 20 | 63386557 |
Neutropenia | 72.68 | 10.28 | 106 | 102339 | 174899 | 63211678 |
Sleep disorder due to general medical condition, insomnia type | 71.28 | 10.28 | 3 | 102442 | 52214 | 63334363 |
Implant site pain | 71.02 | 10.28 | 46 | 102399 | 2394 | 63384183 |
Depression | 70.84 | 10.28 | 551 | 101894 | 195941 | 63190636 |
Device malfunction | 70.27 | 10.28 | 113 | 102332 | 17744 | 63368833 |
Lethargy | 69.79 | 10.28 | 224 | 102221 | 55783 | 63330794 |
Insomnia | 69.17 | 10.28 | 588 | 101857 | 214664 | 63171913 |
Thrombocytopenia | 67.34 | 10.28 | 87 | 102358 | 151070 | 63235507 |
Respiratory depression | 67.03 | 10.28 | 96 | 102349 | 13619 | 63372958 |
Medical device site swelling | 66.86 | 10.28 | 14 | 102431 | 13 | 63386564 |
Lower respiratory tract infection | 66.66 | 10.28 | 69 | 102376 | 132238 | 63254339 |
Pancytopenia | 66.14 | 10.28 | 37 | 102408 | 96896 | 63289681 |
Underdose | 65.43 | 10.28 | 140 | 102305 | 27316 | 63359261 |
Off label use | 65.43 | 10.28 | 735 | 101710 | 673727 | 62712850 |
Device inversion | 65.17 | 10.28 | 12 | 102433 | 0 | 63386577 |
Muscle rigidity | 64.46 | 10.28 | 86 | 102359 | 11414 | 63375163 |
Peroneal nerve palsy | 64.17 | 10.28 | 57 | 102388 | 4778 | 63381799 |
Paraesthesia | 63.27 | 10.28 | 452 | 101993 | 156514 | 63230063 |
Blister | 62.84 | 10.28 | 70 | 102375 | 129744 | 63256833 |
Peripheral swelling | 62.35 | 10.28 | 220 | 102225 | 265722 | 63120855 |
Immune reconstitution inflammatory syndrome | 62.10 | 10.28 | 62 | 102383 | 6022 | 63380555 |
JC polyomavirus test positive | 61.96 | 10.28 | 35 | 102410 | 1418 | 63385159 |
Neuralgia | 61.55 | 10.28 | 132 | 102313 | 25794 | 63360783 |
Asphyxia | 61.27 | 10.28 | 62 | 102383 | 6119 | 63380458 |
Arthralgia | 61.24 | 10.28 | 606 | 101839 | 569104 | 62817473 |
Medical device site erythema | 60.65 | 10.28 | 13 | 102432 | 15 | 63386562 |
Trigeminal neuralgia | 60.15 | 10.28 | 48 | 102397 | 3471 | 63383106 |
Device dislocation | 60.03 | 10.28 | 130 | 102315 | 25575 | 63361002 |
Therapy non-responder | 59.81 | 10.28 | 262 | 102183 | 75639 | 63310938 |
Dyspnoea | 59.36 | 10.28 | 733 | 101712 | 660580 | 62725997 |
Lymphopenia | 58.92 | 10.28 | 106 | 102339 | 18221 | 63368356 |
Neurogenic bladder | 58.71 | 10.28 | 46 | 102399 | 3239 | 63383338 |
Liver injury | 58.48 | 10.28 | 13 | 102432 | 60507 | 63326070 |
Hepatic enzyme increased | 58.42 | 10.28 | 152 | 102293 | 202176 | 63184401 |
Interstitial lung disease | 58.42 | 10.28 | 14 | 102431 | 61894 | 63324683 |
Treatment failure | 57.12 | 10.28 | 150 | 102295 | 198893 | 63187684 |
Optic neuritis | 55.01 | 10.28 | 68 | 102377 | 8367 | 63378210 |
Paraparesis | 54.90 | 10.28 | 38 | 102407 | 2210 | 63384367 |
Acute kidney injury | 53.37 | 10.28 | 231 | 102214 | 263184 | 63123393 |
Concussion | 53.16 | 10.28 | 70 | 102375 | 9174 | 63377403 |
Status epilepticus | 52.72 | 10.28 | 91 | 102354 | 15142 | 63371435 |
Magnetic resonance imaging abnormal | 52.56 | 10.28 | 42 | 102403 | 3043 | 63383534 |
Dystonia | 52.41 | 10.28 | 86 | 102359 | 13733 | 63372844 |
Wound dehiscence | 51.96 | 10.28 | 51 | 102394 | 4852 | 63381725 |
Urosepsis | 51.89 | 10.28 | 101 | 102344 | 18423 | 63368154 |
Hallucination | 50.87 | 10.28 | 199 | 102246 | 54618 | 63331959 |
General physical health deterioration | 50.33 | 10.28 | 162 | 102283 | 201240 | 63185337 |
Agitation | 49.94 | 10.28 | 210 | 102235 | 59547 | 63327030 |
Mucosal inflammation | 49.76 | 10.28 | 8 | 102437 | 46920 | 63339657 |
Drug delivery device placement | 49.72 | 10.28 | 15 | 102430 | 111 | 63386466 |
Generalised tonic-clonic seizure | 49.61 | 10.28 | 130 | 102315 | 28886 | 63357691 |
Neurotoxicity | 49.26 | 10.28 | 94 | 102351 | 16896 | 63369681 |
Flushing | 48.75 | 10.28 | 245 | 102200 | 74842 | 63311735 |
Hyporeflexia | 48.56 | 10.28 | 33 | 102412 | 1862 | 63384715 |
Speech disorder | 48.36 | 10.28 | 160 | 102285 | 40469 | 63346108 |
Hypersensitivity | 48.21 | 10.28 | 276 | 102169 | 292409 | 63094168 |
Sedation | 48.14 | 10.28 | 155 | 102290 | 38654 | 63347923 |
Psoriatic arthropathy | 48.07 | 10.28 | 46 | 102399 | 91474 | 63295103 |
Hypokinesia | 47.90 | 10.28 | 83 | 102362 | 13853 | 63372724 |
Escherichia urinary tract infection | 47.48 | 10.28 | 76 | 102369 | 11886 | 63374691 |
Diplopia | 46.53 | 10.28 | 112 | 102333 | 23616 | 63362961 |
Metabolic encephalopathy | 46.48 | 10.28 | 52 | 102393 | 5757 | 63380820 |
Focal dyscognitive seizures | 46.03 | 10.28 | 38 | 102407 | 2883 | 63383694 |
Areflexia | 45.91 | 10.28 | 39 | 102406 | 3079 | 63383498 |
Medical device site fibrosis | 45.58 | 10.28 | 9 | 102436 | 4 | 63386573 |
Device connection issue | 45.22 | 10.28 | 22 | 102423 | 653 | 63385924 |
Clonus | 45.04 | 10.28 | 46 | 102399 | 4590 | 63381987 |
Respiratory arrest | 44.76 | 10.28 | 135 | 102310 | 32510 | 63354067 |
Paralysis | 43.62 | 10.28 | 66 | 102379 | 9834 | 63376743 |
Laboratory test abnormal | 43.41 | 10.28 | 118 | 102327 | 26794 | 63359783 |
Pleural effusion | 43.22 | 10.28 | 52 | 102393 | 93158 | 63293419 |
Scoliosis | 42.70 | 10.28 | 58 | 102387 | 7830 | 63378747 |
Device alarm issue | 42.47 | 10.28 | 28 | 102417 | 1502 | 63385075 |
Burning sensation | 42.24 | 10.28 | 187 | 102258 | 54220 | 63332357 |
Ankle fracture | 41.35 | 10.28 | 90 | 102355 | 17765 | 63368812 |
Gait spastic | 41.31 | 10.28 | 16 | 102429 | 268 | 63386309 |
Muscle twitching | 40.92 | 10.28 | 95 | 102350 | 19573 | 63367004 |
Pocket erosion | 40.91 | 10.28 | 8 | 102437 | 3 | 63386574 |
Feeling abnormal | 40.79 | 10.28 | 392 | 102053 | 148000 | 63238577 |
Loss of consciousness | 40.74 | 10.28 | 328 | 102117 | 117793 | 63268784 |
Red blood cells urine positive | 39.80 | 10.28 | 36 | 102409 | 3090 | 63383487 |
Pulmonary fibrosis | 39.59 | 10.28 | 8 | 102437 | 39801 | 63346776 |
Motor dysfunction | 39.50 | 10.28 | 66 | 102379 | 10695 | 63375882 |
Irritable bowel syndrome | 39.26 | 10.28 | 45 | 102400 | 82367 | 63304210 |
Infusion site mass | 39.23 | 10.28 | 30 | 102415 | 2038 | 63384539 |
C-reactive protein abnormal | 38.72 | 10.28 | 13 | 102432 | 46083 | 63340494 |
Gait inability | 38.11 | 10.28 | 178 | 102267 | 52781 | 63333796 |
Gastrointestinal haemorrhage | 37.94 | 10.28 | 45 | 102400 | 81131 | 63305446 |
Implant site haematoma | 37.76 | 10.28 | 11 | 102434 | 71 | 63386506 |
Wheezing | 37.64 | 10.28 | 60 | 102385 | 95535 | 63291042 |
Urine leukocyte esterase positive | 37.50 | 10.28 | 37 | 102408 | 3542 | 63383035 |
Depressed level of consciousness | 37.14 | 10.28 | 198 | 102247 | 61880 | 63324697 |
Cardiac failure | 36.97 | 10.28 | 54 | 102391 | 89088 | 63297489 |
Ataxia | 36.80 | 10.28 | 78 | 102367 | 15117 | 63371460 |
Intracranial hypotension | 36.80 | 10.28 | 15 | 102430 | 289 | 63386288 |
Device leakage | 36.64 | 10.28 | 51 | 102394 | 7045 | 63379532 |
Soft tissue injury | 35.89 | 10.28 | 26 | 102419 | 1626 | 63384951 |
Implant site erythema | 35.49 | 10.28 | 18 | 102427 | 585 | 63385992 |
Cough | 35.42 | 10.28 | 302 | 102143 | 292441 | 63094136 |
Blood cholesterol increased | 35.19 | 10.28 | 61 | 102384 | 93971 | 63292606 |
Knee arthroplasty | 35.12 | 10.28 | 22 | 102423 | 54184 | 63332393 |
Decreased appetite | 35.03 | 10.28 | 249 | 102196 | 250803 | 63135774 |
Electroencephalogram abnormal | 34.89 | 10.28 | 36 | 102409 | 3636 | 63382941 |
Myoclonus | 34.51 | 10.28 | 78 | 102367 | 15790 | 63370787 |
COVID-19 | 34.21 | 10.28 | 305 | 102140 | 112798 | 63273779 |
Dysphagia | 33.88 | 10.28 | 252 | 102193 | 88333 | 63298244 |
Nasopharyngitis | 33.65 | 10.28 | 256 | 102189 | 254001 | 63132576 |
Bone marrow failure | 33.39 | 10.28 | 4 | 102441 | 29286 | 63357291 |
Urinary sediment present | 33.35 | 10.28 | 28 | 102417 | 2175 | 63384402 |
Osteonecrosis of jaw | 33.02 | 10.28 | 8 | 102437 | 35115 | 63351462 |
Hostility | 32.99 | 10.28 | 26 | 102419 | 1846 | 63384731 |
Stomatitis | 32.98 | 10.28 | 114 | 102331 | 138611 | 63247966 |
Arteriosclerosis coronary artery | 32.96 | 10.28 | 53 | 102392 | 8320 | 63378257 |
Temperature intolerance | 32.93 | 10.28 | 55 | 102390 | 8909 | 63377668 |
Sensory disturbance | 32.90 | 10.28 | 70 | 102375 | 13602 | 63372975 |
Device expulsion | 32.74 | 10.28 | 8 | 102437 | 34914 | 63351663 |
Nystagmus | 32.56 | 10.28 | 45 | 102400 | 6175 | 63380402 |
Renal impairment | 32.44 | 10.28 | 58 | 102387 | 88297 | 63298280 |
Device occlusion | 32.20 | 10.28 | 49 | 102396 | 7338 | 63379239 |
Hepatic function abnormal | 32.04 | 10.28 | 10 | 102435 | 37132 | 63349445 |
Impaired healing | 31.96 | 10.28 | 74 | 102371 | 102468 | 63284109 |
Ascites | 31.67 | 10.28 | 13 | 102432 | 40715 | 63345862 |
Abdominal pain | 31.48 | 10.28 | 312 | 102133 | 293144 | 63093433 |
Muscle atrophy | 31.15 | 10.28 | 47 | 102398 | 6986 | 63379591 |
Libido increased | 31.13 | 10.28 | 22 | 102423 | 1323 | 63385254 |
White blood cells urine positive | 31.12 | 10.28 | 40 | 102405 | 5118 | 63381459 |
Musculoskeletal stiffness | 30.79 | 10.28 | 443 | 102002 | 184175 | 63202402 |
Nitrite urine present | 30.79 | 10.28 | 20 | 102425 | 1046 | 63385531 |
Hemiparesis | 30.72 | 10.28 | 95 | 102350 | 23187 | 63363390 |
Medical device site discomfort | 30.69 | 10.28 | 13 | 102432 | 277 | 63386300 |
Migraine | 30.39 | 10.28 | 277 | 102168 | 103069 | 63283508 |
Blood creatinine increased | 30.20 | 10.28 | 60 | 102385 | 87784 | 63298793 |
Micturition urgency | 30.14 | 10.28 | 55 | 102390 | 9556 | 63377021 |
Toxic epidermal necrolysis | 30.05 | 10.28 | 3 | 102442 | 25331 | 63361246 |
Expanded disability status scale score increased | 29.95 | 10.28 | 16 | 102429 | 580 | 63385997 |
Vitamin D deficiency | 29.89 | 10.28 | 68 | 102377 | 13824 | 63372753 |
Incision site oedema | 29.72 | 10.28 | 7 | 102438 | 16 | 63386561 |
Monocyte percentage increased | 29.44 | 10.28 | 20 | 102425 | 1128 | 63385449 |
Neoplasm progression | 29.36 | 10.28 | 11 | 102434 | 36417 | 63350160 |
Disease progression | 29.10 | 10.28 | 101 | 102344 | 122657 | 63263920 |
Skin reaction | 29.02 | 10.28 | 70 | 102375 | 14779 | 63371798 |
Device computer issue | 28.79 | 10.28 | 9 | 102436 | 76 | 63386501 |
Dysstasia | 28.52 | 10.28 | 87 | 102358 | 21079 | 63365498 |
Hepatotoxicity | 28.51 | 10.28 | 12 | 102433 | 37029 | 63349548 |
Gastrointestinal disorder | 28.47 | 10.28 | 112 | 102333 | 131127 | 63255450 |
Basal ganglion degeneration | 28.21 | 10.28 | 14 | 102431 | 434 | 63386143 |
Type 2 diabetes mellitus | 28.18 | 10.28 | 37 | 102408 | 63831 | 63322746 |
Coordination abnormal | 28.07 | 10.28 | 66 | 102379 | 13707 | 63372870 |
Platelet count decreased | 27.89 | 10.28 | 95 | 102350 | 116027 | 63270550 |
Bladder disorder | 27.81 | 10.28 | 51 | 102394 | 8895 | 63377682 |
Device issue | 27.72 | 10.28 | 93 | 102352 | 23688 | 63362889 |
Atrial fibrillation | 27.62 | 10.28 | 96 | 102349 | 116540 | 63270037 |
Myelosuppression | 27.62 | 10.28 | 3 | 102442 | 23700 | 63362877 |
Dysarthria | 27.46 | 10.28 | 139 | 102306 | 42572 | 63344005 |
Rheumatoid arthritis | 27.16 | 10.28 | 270 | 102175 | 253549 | 63133028 |
Incoherent | 27.13 | 10.28 | 35 | 102410 | 4495 | 63382082 |
Ill-defined disorder | 27.12 | 10.28 | 57 | 102388 | 81698 | 63304879 |
Thyroid disorder | 27.02 | 10.28 | 69 | 102376 | 15093 | 63371484 |
Sinusitis | 26.87 | 10.28 | 235 | 102210 | 226418 | 63160159 |
Vision blurred | 26.83 | 10.28 | 246 | 102199 | 91678 | 63294899 |
Haemoglobin decreased | 26.81 | 10.28 | 132 | 102313 | 145353 | 63241224 |
Disorientation | 26.50 | 10.28 | 130 | 102315 | 39322 | 63347255 |
Neutrophil percentage increased | 26.43 | 10.28 | 28 | 102417 | 2915 | 63383662 |
Tissue infiltration | 26.41 | 10.28 | 15 | 102430 | 614 | 63385963 |
Medical device discomfort | 26.01 | 10.28 | 23 | 102422 | 1916 | 63384661 |
Anxiety | 25.92 | 10.28 | 494 | 101951 | 217047 | 63169530 |
Dysaesthesia | 25.89 | 10.28 | 34 | 102411 | 4444 | 63382133 |
Renal failure | 25.78 | 10.28 | 100 | 102345 | 117552 | 63269025 |
Muscle contracture | 25.74 | 10.28 | 20 | 102425 | 1391 | 63385186 |
Urinary retention | 25.71 | 10.28 | 107 | 102338 | 30194 | 63356383 |
Intentional product use issue | 25.35 | 10.28 | 113 | 102332 | 127779 | 63258798 |
Medical device site erosion | 25.09 | 10.28 | 6 | 102439 | 15 | 63386562 |
Cognitive disorder | 24.99 | 10.28 | 165 | 102280 | 55650 | 63330927 |
Pollakiuria | 24.77 | 10.28 | 100 | 102345 | 27837 | 63358740 |
Post-traumatic neck syndrome | 24.68 | 10.28 | 23 | 102422 | 2051 | 63384526 |
Aphasia | 24.54 | 10.28 | 112 | 102333 | 32888 | 63353689 |
Monoplegia | 24.50 | 10.28 | 28 | 102417 | 3173 | 63383404 |
Culture urine positive | 24.49 | 10.28 | 30 | 102415 | 3657 | 63382920 |
Palmar-plantar erythrodysaesthesia syndrome | 24.23 | 10.28 | 4 | 102441 | 23011 | 63363566 |
Dyskinesia | 24.09 | 10.28 | 109 | 102336 | 31893 | 63354684 |
Neurogenic bowel | 24.08 | 10.28 | 9 | 102436 | 136 | 63386441 |
Implant site reaction | 23.90 | 10.28 | 9 | 102436 | 139 | 63386438 |
Band neutrophil count increased | 23.86 | 10.28 | 12 | 102433 | 383 | 63386194 |
Asthenia | 23.86 | 10.28 | 798 | 101647 | 382806 | 63003771 |
Loss of control of legs | 23.77 | 10.28 | 19 | 102426 | 1377 | 63385200 |
Disturbance in attention | 23.66 | 10.28 | 123 | 102322 | 38066 | 63348511 |
Dyspnoea exertional | 23.59 | 10.28 | 38 | 102407 | 60264 | 63326313 |
Injury | 23.52 | 10.28 | 52 | 102393 | 73195 | 63313382 |
Sternal fracture | 23.06 | 10.28 | 23 | 102422 | 2231 | 63384346 |
Premature delivery | 23.00 | 10.28 | 10 | 102435 | 30271 | 63356306 |
Implant site scar | 22.94 | 10.28 | 11 | 102434 | 316 | 63386261 |
Lymphocyte percentage decreased | 22.66 | 10.28 | 26 | 102419 | 2959 | 63383618 |
Cardiac failure congestive | 22.62 | 10.28 | 75 | 102370 | 92358 | 63294219 |
Primary progressive multiple sclerosis | 22.37 | 10.28 | 8 | 102437 | 106 | 63386471 |
Upper airway obstruction | 22.32 | 10.28 | 14 | 102431 | 689 | 63385888 |
Pulmonary renal syndrome | 22.29 | 10.28 | 12 | 102433 | 442 | 63386135 |
Hyperhidrosis | 22.23 | 10.28 | 269 | 102176 | 107567 | 63279010 |
Limb discomfort | 22.21 | 10.28 | 101 | 102344 | 29615 | 63356962 |
Hypercalcaemia | 22.08 | 10.28 | 9 | 102436 | 28313 | 63358264 |
Poisoning | 22.02 | 10.28 | 60 | 102385 | 13640 | 63372937 |
Drug resistance | 22.00 | 10.28 | 5 | 102440 | 22928 | 63363649 |
Consciousness fluctuating | 21.98 | 10.28 | 15 | 102430 | 852 | 63385725 |
Multiple organ dysfunction syndrome | 21.98 | 10.28 | 36 | 102409 | 56716 | 63329861 |
Spinal operation | 21.84 | 10.28 | 44 | 102401 | 8227 | 63378350 |
Haematochezia | 21.65 | 10.28 | 33 | 102412 | 53511 | 63333066 |
Colitis microscopic | 21.54 | 10.28 | 47 | 102398 | 9292 | 63377285 |
Bacterial test positive | 21.45 | 10.28 | 34 | 102411 | 5273 | 63381304 |
Device programming error | 21.34 | 10.28 | 8 | 102437 | 122 | 63386455 |
Quadriparesis | 21.30 | 10.28 | 21 | 102424 | 2008 | 63384569 |
Inadequate analgesia | 21.28 | 10.28 | 25 | 102420 | 2918 | 63383659 |
Amnesia | 21.18 | 10.28 | 158 | 102287 | 55427 | 63331150 |
Metastases to liver | 21.05 | 10.28 | 6 | 102439 | 23633 | 63362944 |
B-lymphocyte count decreased | 21.04 | 10.28 | 16 | 102429 | 1078 | 63385499 |
Post procedural complication | 21.00 | 10.28 | 68 | 102377 | 17006 | 63369571 |
Proteinuria | 20.90 | 10.28 | 3 | 102442 | 19142 | 63367435 |
Invasive ductal breast carcinoma | 20.79 | 10.28 | 39 | 102406 | 6919 | 63379658 |
Therapeutic response unexpected | 20.67 | 10.28 | 72 | 102373 | 18687 | 63367890 |
Enthesopathy | 20.61 | 10.28 | 44 | 102401 | 8570 | 63378007 |
Nephrolithiasis | 20.57 | 10.28 | 127 | 102318 | 41857 | 63344720 |
Erythema | 20.48 | 10.28 | 183 | 102262 | 175568 | 63211009 |
Seroma | 20.44 | 10.28 | 21 | 102424 | 2110 | 63384467 |
Therapeutic response decreased | 20.21 | 10.28 | 169 | 102276 | 61356 | 63325221 |
Melaena | 20.12 | 10.28 | 12 | 102433 | 30353 | 63356224 |
Abnormal behaviour | 20.05 | 10.28 | 78 | 102367 | 21348 | 63365229 |
Bacterial test | 20.04 | 10.28 | 16 | 102429 | 1158 | 63385419 |
Anaesthesia | 19.97 | 10.28 | 11 | 102434 | 424 | 63386153 |
Conversion disorder | 19.92 | 10.28 | 19 | 102426 | 1745 | 63384832 |
Injection site scar | 19.82 | 10.28 | 15 | 102430 | 1003 | 63385574 |
Back pain | 19.73 | 10.28 | 562 | 101883 | 263583 | 63122994 |
Stress | 19.72 | 10.28 | 180 | 102265 | 66987 | 63319590 |
Bladder spasm | 19.70 | 10.28 | 19 | 102426 | 1769 | 63384808 |
Hypersomnia | 19.64 | 10.28 | 69 | 102376 | 17986 | 63368591 |
Irritability | 19.57 | 10.28 | 102 | 102343 | 31592 | 63354985 |
Medical device site cellulitis | 19.49 | 10.28 | 4 | 102441 | 3 | 63386574 |
Anal incontinence | 19.42 | 10.28 | 57 | 102388 | 13519 | 63373058 |
Band neutrophil percentage increased | 19.42 | 10.28 | 9 | 102436 | 239 | 63386338 |
Hypothermia | 19.41 | 10.28 | 57 | 102388 | 13524 | 63373053 |
Relapsing-remitting multiple sclerosis | 19.36 | 10.28 | 12 | 102433 | 578 | 63385999 |
Tonic clonic movements | 19.21 | 10.28 | 17 | 102428 | 1418 | 63385159 |
Epistaxis | 19.21 | 10.28 | 57 | 102388 | 72668 | 63313909 |
Abdominal pain upper | 19.11 | 10.28 | 227 | 102218 | 206217 | 63180360 |
Incorrect route of product administration | 18.82 | 10.28 | 91 | 102354 | 27361 | 63359216 |
Bladder dysfunction | 18.71 | 10.28 | 14 | 102431 | 920 | 63385657 |
Frontotemporal dementia | 18.71 | 10.28 | 10 | 102435 | 363 | 63386214 |
Psychogenic seizure | 18.68 | 10.28 | 18 | 102427 | 1674 | 63384903 |
Hyperkalaemia | 18.64 | 10.28 | 37 | 102408 | 54166 | 63332411 |
Staphylococcal infection | 18.49 | 10.28 | 122 | 102323 | 41134 | 63345443 |
Visual impairment | 18.44 | 10.28 | 213 | 102232 | 84233 | 63302344 |
Neurological decompensation | 18.40 | 10.28 | 22 | 102423 | 2616 | 63383961 |
Urinary tract infection bacterial | 18.25 | 10.28 | 31 | 102414 | 5091 | 63381486 |
Thyroxine decreased | 18.25 | 10.28 | 12 | 102433 | 641 | 63385936 |
Hypoglycaemia | 18.19 | 10.28 | 44 | 102401 | 60021 | 63326556 |
Intervertebral disc disorder | 18.17 | 10.28 | 30 | 102415 | 4813 | 63381764 |
Hypomagnesaemia | 18.16 | 10.28 | 12 | 102433 | 28725 | 63357852 |
Drug eruption | 18.10 | 10.28 | 12 | 102433 | 28682 | 63357895 |
Device extrusion | 18.07 | 10.28 | 5 | 102440 | 26 | 63386551 |
Pseudomeningocele | 18.07 | 10.28 | 4 | 102441 | 6 | 63386571 |
Metabolic acidosis | 18.01 | 10.28 | 28 | 102417 | 45041 | 63341536 |
Movement disorder | 17.99 | 10.28 | 76 | 102369 | 21585 | 63364992 |
Rash maculo-papular | 17.98 | 10.28 | 15 | 102430 | 31881 | 63354696 |
Alcohol withdrawal syndrome | 17.93 | 10.28 | 13 | 102432 | 814 | 63385763 |
Stevens-Johnson syndrome | 17.78 | 10.28 | 9 | 102436 | 24941 | 63361636 |
Urobilinogen urine increased | 17.73 | 10.28 | 9 | 102436 | 293 | 63386284 |
Bradypnoea | 17.57 | 10.28 | 25 | 102420 | 3525 | 63383052 |
Myelocyte percentage increased | 17.49 | 10.28 | 8 | 102437 | 206 | 63386371 |
Sleep apnoea syndrome | 17.47 | 10.28 | 93 | 102352 | 29040 | 63357537 |
Back disorder | 17.46 | 10.28 | 48 | 102397 | 10969 | 63375608 |
Cytomegalovirus infection | 17.44 | 10.28 | 6 | 102439 | 20946 | 63365631 |
Rectal haemorrhage | 17.27 | 10.28 | 33 | 102412 | 48997 | 63337580 |
Persistent depressive disorder | 17.26 | 10.28 | 14 | 102431 | 1036 | 63385541 |
Adverse event | 17.09 | 10.28 | 54 | 102391 | 67505 | 63319072 |
Intentional overdose | 17.08 | 10.28 | 189 | 102256 | 73963 | 63312614 |
Major depression | 16.97 | 10.28 | 39 | 102406 | 7979 | 63378598 |
Uterine enlargement | 16.93 | 10.28 | 15 | 102430 | 1253 | 63385324 |
Poisoning deliberate | 16.92 | 10.28 | 48 | 102397 | 11170 | 63375407 |
Hip arthroplasty | 16.84 | 10.28 | 32 | 102413 | 47614 | 63338963 |
Therapy cessation | 16.77 | 10.28 | 95 | 102350 | 30362 | 63356215 |
Neuromuscular toxicity | 16.57 | 10.28 | 7 | 102438 | 148 | 63386429 |
Agranulocytosis | 16.56 | 10.28 | 10 | 102435 | 25124 | 63361453 |
Neutrophil count decreased | 16.55 | 10.28 | 42 | 102403 | 56364 | 63330213 |
Hypervolaemia | 16.47 | 10.28 | 13 | 102432 | 28400 | 63358177 |
Rash pruritic | 16.43 | 10.28 | 46 | 102399 | 59753 | 63326824 |
Cholestasis | 16.40 | 10.28 | 14 | 102431 | 29420 | 63357157 |
Urinary tract infection enterococcal | 16.31 | 10.28 | 21 | 102424 | 2692 | 63383885 |
Medical device site bruise | 16.29 | 10.28 | 3 | 102442 | 0 | 63386577 |
Implant site ulcer | 16.29 | 10.28 | 3 | 102442 | 0 | 63386577 |
Injection site necrosis | 16.18 | 10.28 | 15 | 102430 | 1329 | 63385248 |
Neuropsychiatric syndrome | 16.13 | 10.28 | 5 | 102440 | 41 | 63386536 |
Head injury | 16.12 | 10.28 | 87 | 102358 | 27309 | 63359268 |
CD8 lymphocytes decreased | 16.03 | 10.28 | 7 | 102438 | 161 | 63386416 |
Urine oxalate increased | 15.95 | 10.28 | 8 | 102437 | 254 | 63386323 |
Posturing | 15.94 | 10.28 | 10 | 102435 | 492 | 63386085 |
Poor quality sleep | 15.83 | 10.28 | 69 | 102376 | 19866 | 63366711 |
Intervertebral disc protrusion | 15.83 | 10.28 | 78 | 102367 | 23631 | 63362946 |
Neurosis | 15.78 | 10.28 | 8 | 102437 | 260 | 63386317 |
Acute hepatic failure | 15.69 | 10.28 | 5 | 102440 | 18322 | 63368255 |
Haemoglobin increased | 15.63 | 10.28 | 24 | 102421 | 3622 | 63382955 |
Oedema | 15.53 | 10.28 | 93 | 102352 | 97529 | 63289048 |
Foot fracture | 15.49 | 10.28 | 78 | 102367 | 23836 | 63362741 |
Glaucoma | 15.45 | 10.28 | 66 | 102379 | 18839 | 63367738 |
Reflexes abnormal | 15.44 | 10.28 | 11 | 102434 | 670 | 63385907 |
CD4 lymphocytes decreased | 15.41 | 10.28 | 15 | 102430 | 1412 | 63385165 |
Frequent bowel movements | 15.39 | 10.28 | 9 | 102436 | 23013 | 63363564 |
Urinary tract infection pseudomonal | 15.36 | 10.28 | 12 | 102433 | 841 | 63385736 |
Meningitis | 15.29 | 10.28 | 35 | 102410 | 7142 | 63379435 |
Confusional state | 15.25 | 10.28 | 494 | 101951 | 235886 | 63150691 |
Pulmonary oedema | 15.23 | 10.28 | 42 | 102403 | 54831 | 63331746 |
Retinal depigmentation | 15.10 | 10.28 | 8 | 102437 | 285 | 63386292 |
Eosinophilia | 15.07 | 10.28 | 9 | 102436 | 22747 | 63363830 |
Colitis ulcerative | 15.04 | 10.28 | 12 | 102433 | 26079 | 63360498 |
Lipoedema | 14.97 | 10.28 | 8 | 102437 | 290 | 63386287 |
Liver disorder | 14.97 | 10.28 | 41 | 102404 | 53646 | 63332931 |
Lymphocyte count abnormal | 14.96 | 10.28 | 11 | 102434 | 704 | 63385873 |
Intraductal proliferative breast lesion | 14.96 | 10.28 | 21 | 102424 | 2924 | 63383653 |
Pneumonitis | 14.93 | 10.28 | 21 | 102424 | 35201 | 63351376 |
Abnormal dreams | 14.90 | 10.28 | 44 | 102401 | 10472 | 63376105 |
Hypochromic anaemia | 14.88 | 10.28 | 17 | 102428 | 1925 | 63384652 |
Injection site infection | 14.88 | 10.28 | 17 | 102428 | 1926 | 63384651 |
Invasive lobular breast carcinoma | 14.85 | 10.28 | 12 | 102433 | 883 | 63385694 |
Suicidal ideation | 14.79 | 10.28 | 160 | 102285 | 62261 | 63324316 |
Pregnancy | 14.61 | 10.28 | 23 | 102422 | 36813 | 63349764 |
Intentional self-injury | 14.58 | 10.28 | 12 | 102433 | 25675 | 63360902 |
Bronchiectasis | 14.56 | 10.28 | 4 | 102441 | 16138 | 63370439 |
T-lymphocyte count decreased | 14.53 | 10.28 | 8 | 102437 | 308 | 63386269 |
Intestinal polyp | 14.49 | 10.28 | 15 | 102430 | 1520 | 63385057 |
Noninfective encephalitis | 14.49 | 10.28 | 9 | 102436 | 435 | 63386142 |
Chronic fatigue syndrome | 14.48 | 10.28 | 13 | 102432 | 1105 | 63385472 |
Product dose omission issue | 14.43 | 10.28 | 487 | 101958 | 233826 | 63152751 |
Needle fatigue | 14.42 | 10.28 | 6 | 102439 | 122 | 63386455 |
Injection site mass | 14.38 | 10.28 | 64 | 102381 | 18592 | 63367985 |
Metastases to bone | 14.36 | 10.28 | 8 | 102437 | 21011 | 63365566 |
Injection site ulcer | 14.35 | 10.28 | 10 | 102435 | 588 | 63385989 |
Nausea | 14.34 | 10.28 | 1186 | 101259 | 853285 | 62533292 |
Macular degeneration | 14.32 | 10.28 | 11 | 102434 | 24365 | 63362212 |
Productive cough | 14.31 | 10.28 | 53 | 102392 | 63155 | 63323422 |
Medical device site scar | 14.22 | 10.28 | 3 | 102442 | 3 | 63386574 |
Quadriplegia | 14.21 | 10.28 | 16 | 102429 | 1784 | 63384793 |
Autonomic nervous system imbalance | 14.17 | 10.28 | 20 | 102425 | 2798 | 63383779 |
Rotator cuff syndrome | 14.17 | 10.28 | 51 | 102394 | 13451 | 63373126 |
Stiff person syndrome | 14.17 | 10.28 | 8 | 102437 | 324 | 63386253 |
Pupil fixed | 14.14 | 10.28 | 16 | 102429 | 1793 | 63384784 |
Euphoric mood | 14.12 | 10.28 | 27 | 102418 | 4860 | 63381717 |
Urine osmolarity increased | 14.07 | 10.28 | 6 | 102439 | 130 | 63386447 |
Decreased vibratory sense | 14.01 | 10.28 | 8 | 102437 | 331 | 63386246 |
Infection | 13.99 | 10.28 | 273 | 102172 | 228900 | 63157677 |
Cytokine release syndrome | 13.98 | 10.28 | 3 | 102442 | 14311 | 63372266 |
Pneumocystis jirovecii pneumonia | 13.81 | 10.28 | 5 | 102440 | 16909 | 63369668 |
Apnoea | 13.77 | 10.28 | 36 | 102409 | 7986 | 63378591 |
Cerebral vasoconstriction | 13.62 | 10.28 | 13 | 102432 | 1195 | 63385382 |
Lung disorder | 13.58 | 10.28 | 53 | 102392 | 62208 | 63324369 |
Paraplegia | 13.49 | 10.28 | 19 | 102426 | 2653 | 63383924 |
Neck pain | 13.46 | 10.28 | 171 | 102274 | 69147 | 63317430 |
Narcotic bowel syndrome | 13.39 | 10.28 | 6 | 102439 | 147 | 63386430 |
Myelocyte count increased | 13.36 | 10.28 | 8 | 102437 | 362 | 63386215 |
Medical device site extravasation | 13.36 | 10.28 | 3 | 102442 | 5 | 63386572 |
Road traffic accident | 13.32 | 10.28 | 103 | 102342 | 36529 | 63350048 |
Feeling hot | 13.32 | 10.28 | 132 | 102313 | 50222 | 63336355 |
International normalised ratio increased | 13.29 | 10.28 | 35 | 102410 | 46390 | 63340187 |
Sports injury | 13.21 | 10.28 | 4 | 102441 | 30 | 63386547 |
Cerebral palsy | 13.21 | 10.28 | 6 | 102439 | 152 | 63386425 |
Pre-existing condition improved | 13.15 | 10.28 | 36 | 102409 | 8208 | 63378369 |
Hallucinations, mixed | 13.12 | 10.28 | 26 | 102419 | 4803 | 63381774 |
Incontinence | 13.12 | 10.28 | 45 | 102400 | 11587 | 63374990 |
Hyperaesthesia | 13.11 | 10.28 | 39 | 102406 | 9319 | 63377258 |
Pancreatitis chronic | 13.05 | 10.28 | 18 | 102427 | 2466 | 63384111 |
Creatinine renal clearance decreased | 13.01 | 10.28 | 5 | 102440 | 16303 | 63370274 |
Congenital megacolon | 13.01 | 10.28 | 3 | 102442 | 6 | 63386571 |
Hepatitis | 12.97 | 10.28 | 28 | 102417 | 39760 | 63346817 |
Weight increased | 12.95 | 10.28 | 321 | 102124 | 260471 | 63126106 |
Product use in unapproved indication | 12.94 | 10.28 | 207 | 102238 | 178873 | 63207704 |
Incorrect drug administration rate | 12.84 | 10.28 | 23 | 102422 | 3939 | 63382638 |
Cataract | 12.81 | 10.28 | 48 | 102397 | 57005 | 63329572 |
Inguinal hernia | 12.80 | 10.28 | 16 | 102429 | 1991 | 63384586 |
Drug interaction | 12.79 | 10.28 | 277 | 102168 | 228854 | 63157723 |
Nightmare | 12.71 | 10.28 | 63 | 102382 | 19131 | 63367446 |
Red blood cell sedimentation rate increased | 12.71 | 10.28 | 33 | 102412 | 43949 | 63342628 |
Medical device site reaction | 12.69 | 10.28 | 3 | 102442 | 7 | 63386570 |
Angina pectoris | 12.68 | 10.28 | 18 | 102427 | 30060 | 63356517 |
Craniocerebral injury | 12.65 | 10.28 | 19 | 102426 | 2813 | 63383764 |
Middle insomnia | 12.63 | 10.28 | 47 | 102398 | 12596 | 63373981 |
Right ventricular failure | 12.55 | 10.28 | 6 | 102439 | 17182 | 63369395 |
Cardio-respiratory arrest | 12.54 | 10.28 | 150 | 102295 | 59809 | 63326768 |
Glycosylated haemoglobin decreased | 12.51 | 10.28 | 9 | 102436 | 557 | 63386020 |
Postoperative delirium | 12.48 | 10.28 | 5 | 102440 | 92 | 63386485 |
Joint effusion | 12.39 | 10.28 | 6 | 102439 | 17054 | 63369523 |
Hyponatraemia | 12.39 | 10.28 | 118 | 102327 | 111782 | 63274795 |
Occupational dermatitis | 12.29 | 10.28 | 4 | 102441 | 39 | 63386538 |
Aspiration | 12.26 | 10.28 | 42 | 102403 | 10809 | 63375768 |
Pulmonary hypertension | 12.21 | 10.28 | 26 | 102419 | 37097 | 63349480 |
Urticaria | 12.20 | 10.28 | 191 | 102254 | 165611 | 63220966 |
Altered state of consciousness | 12.16 | 10.28 | 76 | 102369 | 25154 | 63361423 |
Enlarged uvula | 12.15 | 10.28 | 6 | 102439 | 184 | 63386393 |
Cystitis | 12.14 | 10.28 | 139 | 102306 | 54852 | 63331725 |
Fibromyalgia | 12.08 | 10.28 | 78 | 102367 | 80342 | 63306235 |
Tibia fracture | 12.07 | 10.28 | 26 | 102419 | 5094 | 63381483 |
Increased tendency to bruise | 12.06 | 10.28 | 41 | 102404 | 10511 | 63376066 |
Bladder catheterisation | 11.99 | 10.28 | 7 | 102438 | 302 | 63386275 |
Clubbing | 11.99 | 10.28 | 8 | 102437 | 438 | 63386139 |
Specific gravity urine decreased | 11.96 | 10.28 | 10 | 102435 | 772 | 63385805 |
Automatic bladder | 11.96 | 10.28 | 5 | 102440 | 103 | 63386474 |
Klebsiella test positive | 11.94 | 10.28 | 12 | 102433 | 1175 | 63385402 |
Macular oedema | 11.92 | 10.28 | 22 | 102423 | 3855 | 63382722 |
Acquired diaphragmatic eventration | 11.89 | 10.28 | 8 | 102437 | 444 | 63386133 |
Crystal urine present | 11.87 | 10.28 | 14 | 102431 | 1640 | 63384937 |
Demyelination | 11.82 | 10.28 | 31 | 102414 | 6889 | 63379688 |
Dysuria | 11.79 | 10.28 | 94 | 102351 | 33644 | 63352933 |
Therapeutic product effect incomplete | 11.76 | 10.28 | 137 | 102308 | 124919 | 63261658 |
Botulism | 11.75 | 10.28 | 6 | 102439 | 198 | 63386379 |
Vitamin B6 deficiency | 11.74 | 10.28 | 5 | 102440 | 108 | 63386469 |
Eye movement disorder | 11.70 | 10.28 | 26 | 102419 | 5202 | 63381375 |
Neutralising antibodies | 11.70 | 10.28 | 4 | 102441 | 46 | 63386531 |
Crying | 11.68 | 10.28 | 71 | 102374 | 23272 | 63363305 |
CSF test abnormal | 11.64 | 10.28 | 7 | 102438 | 319 | 63386258 |
Hypoxic-ischaemic encephalopathy | 11.55 | 10.28 | 23 | 102422 | 4264 | 63382313 |
Medical device change | 11.55 | 10.28 | 7 | 102438 | 324 | 63386253 |
Mechanical urticaria | 11.52 | 10.28 | 8 | 102437 | 468 | 63386109 |
CSF culture positive | 11.48 | 10.28 | 3 | 102442 | 12 | 63386565 |
Infusion site macule | 11.48 | 10.28 | 3 | 102442 | 12 | 63386565 |
Injection site atrophy | 11.48 | 10.28 | 9 | 102436 | 634 | 63385943 |
Brain injury | 11.48 | 10.28 | 31 | 102414 | 7012 | 63379565 |
Premature labour | 11.46 | 10.28 | 3 | 102442 | 12501 | 63374076 |
Premature baby | 11.38 | 10.28 | 10 | 102435 | 20725 | 63365852 |
Dehydration | 11.35 | 10.28 | 204 | 102241 | 173150 | 63213427 |
Haemoptysis | 11.33 | 10.28 | 18 | 102427 | 28708 | 63357869 |
Delirium | 11.26 | 10.28 | 128 | 102317 | 50413 | 63336164 |
Optic atrophy | 11.20 | 10.28 | 12 | 102433 | 1266 | 63385311 |
Spinal cord disorder | 11.17 | 10.28 | 12 | 102433 | 1269 | 63385308 |
Prescribed overdose | 11.16 | 10.28 | 24 | 102421 | 34129 | 63352448 |
Citrobacter test positive | 11.11 | 10.28 | 3 | 102442 | 14 | 63386563 |
Blood potassium increased | 11.09 | 10.28 | 8 | 102437 | 18301 | 63368276 |
Implant site fibrosis | 11.07 | 10.28 | 6 | 102439 | 224 | 63386353 |
Intervertebral disc operation | 11.07 | 10.28 | 10 | 102435 | 857 | 63385720 |
Tender joint count | 11.05 | 10.28 | 6 | 102439 | 225 | 63386352 |
Incision site swelling | 11.05 | 10.28 | 6 | 102439 | 225 | 63386352 |
Hypervigilance | 11.04 | 10.28 | 7 | 102438 | 351 | 63386226 |
Affective disorder | 10.98 | 10.28 | 28 | 102417 | 6118 | 63380459 |
Obstructive defaecation | 10.94 | 10.28 | 3 | 102442 | 15 | 63386562 |
Personality disorder | 10.93 | 10.28 | 27 | 102418 | 5784 | 63380793 |
CSF protein increased | 10.87 | 10.28 | 8 | 102437 | 513 | 63386064 |
Catatonia | 10.86 | 10.28 | 23 | 102422 | 4454 | 63382123 |
Hyporesponsive to stimuli | 10.81 | 10.28 | 11 | 102434 | 1093 | 63385484 |
Respiratory rate decreased | 10.80 | 10.28 | 20 | 102425 | 3515 | 63383062 |
Device breakage | 10.78 | 10.28 | 42 | 102403 | 11500 | 63375077 |
Implant site dehiscence | 10.78 | 10.28 | 3 | 102442 | 16 | 63386561 |
Rash erythematous | 10.74 | 10.28 | 34 | 102411 | 42476 | 63344101 |
Blood pressure diastolic abnormal | 10.74 | 10.28 | 5 | 102440 | 14537 | 63372040 |
Pancreatitis acute | 10.74 | 10.28 | 17 | 102428 | 27149 | 63359428 |
Decreased interest | 10.69 | 10.28 | 19 | 102426 | 3235 | 63383342 |
Hyperlipasaemia | 10.66 | 10.28 | 9 | 102436 | 704 | 63385873 |
Meningioma | 10.66 | 10.28 | 21 | 102424 | 3864 | 63382713 |
Miosis | 10.64 | 10.28 | 31 | 102414 | 7322 | 63379255 |
Blood bilirubin increased | 10.63 | 10.28 | 28 | 102417 | 37112 | 63349465 |
Spinal stenosis | 10.61 | 10.28 | 50 | 102395 | 14875 | 63371702 |
Metastases to central nervous system | 10.49 | 10.28 | 4 | 102441 | 13101 | 63373476 |
Viral titre decreased | 10.48 | 10.28 | 3 | 102442 | 18 | 63386559 |
Tremor neonatal | 10.45 | 10.28 | 5 | 102440 | 143 | 63386434 |
Migraine without aura | 10.44 | 10.28 | 7 | 102438 | 386 | 63386191 |
Mean platelet volume increased | 10.43 | 10.28 | 8 | 102437 | 546 | 63386031 |
Hyperpyrexia | 10.41 | 10.28 | 20 | 102425 | 3612 | 63382965 |
Lip dry | 10.41 | 10.28 | 6 | 102439 | 15464 | 63371113 |
Asthma | 10.41 | 10.28 | 144 | 102301 | 127417 | 63259160 |
Neutrophil percentage abnormal | 10.35 | 10.28 | 3 | 102442 | 19 | 63386558 |
Hepatic cytolysis | 10.33 | 10.28 | 6 | 102439 | 15401 | 63371176 |
Abdominal symptom | 10.33 | 10.28 | 7 | 102438 | 393 | 63386184 |
Psychotic disorder | 10.31 | 10.28 | 74 | 102371 | 25638 | 63360939 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug withdrawal syndrome | 1553.80 | 11.20 | 732 | 59115 | 19102 | 34877982 |
Muscle spasticity | 1313.10 | 11.20 | 461 | 59386 | 5427 | 34891657 |
Implant site infection | 784.11 | 11.20 | 210 | 59637 | 880 | 34896204 |
Implant site extravasation | 635.23 | 11.20 | 146 | 59701 | 261 | 34896823 |
Multiple sclerosis relapse | 500.42 | 11.20 | 300 | 59547 | 12833 | 34884251 |
Device failure | 428.13 | 11.20 | 159 | 59688 | 2217 | 34894867 |
Multiple sclerosis | 402.34 | 11.20 | 206 | 59641 | 6439 | 34890645 |
Muscle spasms | 388.81 | 11.20 | 556 | 59291 | 74445 | 34822639 |
Coma | 325.41 | 11.20 | 396 | 59451 | 45282 | 34851802 |
Overdose | 305.69 | 11.20 | 554 | 59293 | 90505 | 34806579 |
Complication associated with device | 292.38 | 11.20 | 161 | 59686 | 5845 | 34891239 |
Hypertonia | 269.75 | 11.20 | 136 | 59711 | 4110 | 34892974 |
Urinary tract infection | 266.34 | 11.20 | 499 | 59348 | 83582 | 34813502 |
Hypotonia | 259.85 | 11.20 | 164 | 59683 | 7689 | 34889395 |
Mental status changes | 254.82 | 11.20 | 320 | 59527 | 37763 | 34859321 |
Therapy non-responder | 254.12 | 11.20 | 324 | 59523 | 38822 | 34858262 |
Cerebrospinal fluid leakage | 234.37 | 11.20 | 70 | 59777 | 466 | 34896618 |
Device infusion issue | 227.04 | 11.20 | 77 | 59770 | 808 | 34896276 |
Implant site erosion | 224.71 | 11.20 | 47 | 59800 | 38 | 34897046 |
Implant site swelling | 205.46 | 11.20 | 43 | 59804 | 35 | 34897049 |
Medical device site infection | 202.59 | 11.20 | 55 | 59792 | 245 | 34896839 |
Withdrawal syndrome | 198.22 | 11.20 | 167 | 59680 | 12288 | 34884796 |
Device kink | 196.03 | 11.20 | 58 | 59789 | 372 | 34896712 |
Device physical property issue | 191.15 | 11.20 | 67 | 59780 | 782 | 34896302 |
Respiratory depression | 171.20 | 11.20 | 173 | 59674 | 16072 | 34881012 |
Toxicity to various agents | 168.67 | 11.20 | 734 | 59113 | 199628 | 34697456 |
Device power source issue | 163.69 | 11.20 | 49 | 59798 | 329 | 34896755 |
Somnolence | 160.82 | 11.20 | 486 | 59361 | 110630 | 34786454 |
Medical device site swelling | 160.23 | 11.20 | 31 | 59816 | 7 | 34897077 |
Implant site pain | 159.04 | 11.20 | 38 | 59809 | 87 | 34896997 |
Muscle tightness | 156.59 | 11.20 | 100 | 59747 | 4784 | 34892300 |
Pocket erosion | 144.99 | 11.20 | 28 | 59819 | 6 | 34897078 |
Medical device site discharge | 137.29 | 11.20 | 27 | 59820 | 9 | 34897075 |
Implant site discharge | 134.28 | 11.20 | 26 | 59821 | 6 | 34897078 |
Therapeutic response decreased | 132.48 | 11.20 | 204 | 59643 | 29109 | 34867975 |
Seizure | 130.96 | 11.20 | 436 | 59411 | 104421 | 34792663 |
Wound dehiscence | 126.99 | 11.20 | 76 | 59771 | 3235 | 34893849 |
Completed suicide | 126.89 | 11.20 | 413 | 59434 | 97755 | 34799329 |
Febrile neutropenia | 123.90 | 11.20 | 40 | 59807 | 136809 | 34760275 |
Implant site erythema | 121.20 | 11.20 | 26 | 59821 | 27 | 34897057 |
Anaemia | 119.70 | 11.20 | 134 | 59713 | 233201 | 34663883 |
Medical device site erythema | 116.10 | 11.20 | 24 | 59823 | 17 | 34897067 |
Clonus | 115.65 | 11.20 | 67 | 59780 | 2683 | 34894401 |
Device dislocation | 114.56 | 11.20 | 91 | 59756 | 6158 | 34890926 |
Unresponsive to stimuli | 112.34 | 11.20 | 183 | 59664 | 27386 | 34869698 |
Sedation | 108.99 | 11.20 | 156 | 59691 | 20850 | 34876234 |
Diarrhoea | 104.60 | 11.20 | 332 | 59515 | 389580 | 34507504 |
Gait disturbance | 101.82 | 11.20 | 349 | 59498 | 84791 | 34812293 |
Toxic encephalopathy | 101.75 | 11.20 | 79 | 59768 | 5170 | 34891914 |
Encephalopathy | 101.08 | 11.20 | 201 | 59646 | 35118 | 34861966 |
Medical device site erosion | 100.39 | 11.20 | 21 | 59826 | 17 | 34897067 |
Medical device site pain | 100.13 | 11.20 | 24 | 59823 | 56 | 34897028 |
Gait spastic | 99.87 | 11.20 | 45 | 59802 | 1051 | 34896033 |
Decubitus ulcer | 99.50 | 11.20 | 98 | 59749 | 8823 | 34888261 |
Device issue | 99.14 | 11.20 | 102 | 59745 | 9675 | 34887409 |
Relapsing-remitting multiple sclerosis | 95.33 | 11.20 | 43 | 59804 | 1007 | 34896077 |
Fall | 90.73 | 11.20 | 626 | 59221 | 202259 | 34694825 |
Device alarm issue | 90.61 | 11.20 | 36 | 59811 | 608 | 34896476 |
Pain | 87.12 | 11.20 | 624 | 59223 | 204051 | 34693033 |
Neutropenia | 87.11 | 11.20 | 84 | 59763 | 156694 | 34740390 |
Neurotoxicity | 86.54 | 11.20 | 129 | 59718 | 17881 | 34879203 |
Needle fatigue | 86.13 | 11.20 | 38 | 59809 | 843 | 34896241 |
Device breakage | 83.58 | 11.20 | 51 | 59796 | 2249 | 34894835 |
Device malfunction | 81.77 | 11.20 | 95 | 59752 | 10326 | 34886758 |
Implant site scar | 80.58 | 11.20 | 15 | 59832 | 0 | 34897084 |
Infusion site mass | 80.56 | 11.20 | 28 | 59819 | 318 | 34896766 |
Central nervous system lesion | 79.63 | 11.20 | 75 | 59772 | 6388 | 34890696 |
Intentional overdose | 78.70 | 11.20 | 207 | 59640 | 43467 | 34853617 |
Underdose | 78.43 | 11.20 | 107 | 59740 | 13673 | 34883411 |
Confusional state | 77.39 | 11.20 | 466 | 59381 | 143694 | 34753390 |
Device connection issue | 75.99 | 11.20 | 28 | 59819 | 381 | 34896703 |
Hypertonic bladder | 74.65 | 11.20 | 44 | 59803 | 1820 | 34895264 |
Intracranial hypotension | 73.65 | 11.20 | 24 | 59823 | 220 | 34896864 |
Cardiac failure | 73.61 | 11.20 | 32 | 59815 | 91216 | 34805868 |
Movement disorder | 72.59 | 11.20 | 97 | 59750 | 12151 | 34884933 |
Thrombocytopenia | 71.33 | 11.20 | 98 | 59749 | 156149 | 34740935 |
Interstitial lung disease | 70.88 | 11.20 | 13 | 59834 | 65269 | 34831815 |
Muscular weakness | 70.45 | 11.20 | 279 | 59568 | 72618 | 34824466 |
Dyspnoea | 70.04 | 11.20 | 370 | 59477 | 376412 | 34520672 |
Hypoaesthesia | 69.20 | 11.20 | 247 | 59600 | 61197 | 34835887 |
Device computer issue | 68.89 | 11.20 | 14 | 59833 | 8 | 34897076 |
Malignant neoplasm progression | 66.22 | 11.20 | 34 | 59813 | 88012 | 34809072 |
Urinary incontinence | 65.92 | 11.20 | 117 | 59730 | 18757 | 34878327 |
Victim of child abuse | 65.72 | 11.20 | 32 | 59815 | 895 | 34896189 |
Neurogenic bladder | 65.36 | 11.20 | 40 | 59807 | 1773 | 34895311 |
Monoparesis | 65.36 | 11.20 | 44 | 59803 | 2302 | 34894782 |
Agitation | 64.86 | 11.20 | 231 | 59616 | 57168 | 34839916 |
Status epilepticus | 64.43 | 11.20 | 93 | 59754 | 12521 | 34884563 |
Balance disorder | 62.65 | 11.20 | 182 | 59665 | 40472 | 34856612 |
Secondary progressive multiple sclerosis | 62.46 | 11.20 | 24 | 59823 | 369 | 34896715 |
Bradypnoea | 62.41 | 11.20 | 46 | 59801 | 2783 | 34894301 |
Acute kidney injury | 60.88 | 11.20 | 292 | 59555 | 304696 | 34592388 |
Atrial fibrillation | 60.78 | 11.20 | 72 | 59775 | 122321 | 34774763 |
Ataxia | 59.21 | 11.20 | 94 | 59753 | 13759 | 34883325 |
Medical device site fibrosis | 59.09 | 11.20 | 11 | 59836 | 0 | 34897084 |
Dystonia | 58.40 | 11.20 | 82 | 59765 | 10763 | 34886321 |
Pancytopenia | 57.60 | 11.20 | 47 | 59800 | 95110 | 34801974 |
Autonomic nervous system imbalance | 57.45 | 11.20 | 42 | 59805 | 2509 | 34894575 |
Tremor | 55.64 | 11.20 | 284 | 59563 | 82303 | 34814781 |
Death | 55.41 | 11.20 | 427 | 59420 | 397622 | 34499462 |
Device occlusion | 53.59 | 11.20 | 61 | 59786 | 6484 | 34890600 |
Epidural lipomatosis | 53.34 | 11.20 | 29 | 59818 | 1025 | 34896059 |
Depressed level of consciousness | 52.37 | 11.20 | 177 | 59670 | 42664 | 34854420 |
Renal impairment | 52.03 | 11.20 | 51 | 59796 | 94462 | 34802622 |
Trigeminal neuralgia | 51.83 | 11.20 | 30 | 59817 | 1199 | 34895885 |
Cardiac failure congestive | 51.81 | 11.20 | 40 | 59807 | 83230 | 34813854 |
Autonomic dysreflexia | 50.75 | 11.20 | 14 | 59833 | 67 | 34897017 |
Arachnoiditis | 49.48 | 11.20 | 20 | 59827 | 354 | 34896730 |
Drug dependence | 49.04 | 11.20 | 120 | 59727 | 24097 | 34872987 |
Platelet count decreased | 48.89 | 11.20 | 81 | 59766 | 119636 | 34777448 |
Micturition urgency | 48.72 | 11.20 | 58 | 59789 | 6467 | 34890617 |
Progressive multiple sclerosis | 48.58 | 11.20 | 18 | 59829 | 249 | 34896835 |
Medical device site discomfort | 48.35 | 11.20 | 9 | 59838 | 0 | 34897084 |
Medical device site inflammation | 48.35 | 11.20 | 9 | 59838 | 0 | 34897084 |
Renal failure | 48.24 | 11.20 | 94 | 59753 | 130463 | 34766621 |
Rash | 47.52 | 11.20 | 208 | 59639 | 222544 | 34674540 |
Hyperkalaemia | 46.21 | 11.20 | 31 | 59816 | 69358 | 34827726 |
Medical device discomfort | 44.94 | 11.20 | 11 | 59836 | 29 | 34897055 |
Blood creatinine increased | 44.90 | 11.20 | 58 | 59789 | 94918 | 34802166 |
Delirium | 44.61 | 11.20 | 171 | 59676 | 43820 | 34853264 |
Post lumbar puncture syndrome | 44.36 | 11.20 | 16 | 59831 | 204 | 34896880 |
General physical health deterioration | 43.47 | 11.20 | 97 | 59750 | 128172 | 34768912 |
Implant site abscess | 43.45 | 11.20 | 10 | 59837 | 18 | 34897066 |
Pneumonia aspiration | 43.41 | 11.20 | 164 | 59683 | 41739 | 34855345 |
Medical device site cellulitis | 42.98 | 11.20 | 8 | 59839 | 0 | 34897084 |
Urosepsis | 42.97 | 11.20 | 78 | 59769 | 12721 | 34884363 |
Urinary retention | 41.79 | 11.20 | 147 | 59700 | 36141 | 34860943 |
Dyskinesia | 41.14 | 11.20 | 107 | 59740 | 22306 | 34874778 |
Hyperreflexia | 41.02 | 11.20 | 38 | 59809 | 3168 | 34893916 |
Implant site vesicles | 40.43 | 11.20 | 8 | 59839 | 3 | 34897081 |
Respiratory rate decreased | 40.37 | 11.20 | 33 | 59814 | 2326 | 34894758 |
Medical device site bruise | 39.74 | 11.20 | 8 | 59839 | 4 | 34897080 |
Implant site cellulitis | 38.96 | 11.20 | 10 | 59837 | 34 | 34897050 |
Rheumatoid arthritis | 38.63 | 11.20 | 9 | 59838 | 38229 | 34858855 |
Medical device site reaction | 38.51 | 11.20 | 8 | 59839 | 6 | 34897078 |
Leukopenia | 38.08 | 11.20 | 31 | 59816 | 62825 | 34834259 |
Implant site haematoma | 37.25 | 11.20 | 11 | 59836 | 70 | 34897014 |
Abdominal pain | 37.20 | 11.20 | 149 | 59698 | 163469 | 34733615 |
Lymphocyte percentage decreased | 36.85 | 11.20 | 30 | 59817 | 2102 | 34894982 |
Medical device site haematoma | 36.69 | 11.20 | 9 | 59838 | 24 | 34897060 |
Lethargy | 36.22 | 11.20 | 153 | 59694 | 40969 | 34856115 |
Gastrointestinal haemorrhage | 35.98 | 11.20 | 60 | 59787 | 88417 | 34808667 |
Altered state of consciousness | 35.75 | 11.20 | 103 | 59744 | 22790 | 34874294 |
Brain stem syndrome | 35.60 | 11.20 | 18 | 59829 | 547 | 34896537 |
Disease progression | 35.58 | 11.20 | 83 | 59764 | 107994 | 34789090 |
Juvenile idiopathic arthritis | 35.57 | 11.20 | 28 | 59819 | 1869 | 34895215 |
Incision site erythema | 35.41 | 11.20 | 11 | 59836 | 85 | 34896999 |
Myoclonus | 35.33 | 11.20 | 78 | 59769 | 14647 | 34882437 |
Insomnia | 34.80 | 11.20 | 300 | 59547 | 103607 | 34793477 |
Stiff person syndrome | 34.75 | 11.20 | 11 | 59836 | 91 | 34896993 |
Cough | 34.59 | 11.20 | 136 | 59711 | 150004 | 34747080 |
Poisoning deliberate | 34.59 | 11.20 | 54 | 59793 | 7790 | 34889294 |
Sleep apnoea syndrome | 34.25 | 11.20 | 94 | 59753 | 20227 | 34876857 |
Drug interaction | 33.90 | 11.20 | 237 | 59610 | 225709 | 34671375 |
Musculoskeletal stiffness | 33.87 | 11.20 | 164 | 59683 | 46516 | 34850568 |
Mucosal inflammation | 33.67 | 11.20 | 12 | 59835 | 38610 | 34858474 |
Infusion related reaction | 33.62 | 11.20 | 25 | 59822 | 53032 | 34844052 |
Muscle twitching | 33.61 | 11.20 | 62 | 59785 | 10236 | 34886848 |
Dyspnoea exertional | 33.60 | 11.20 | 16 | 59831 | 43263 | 34853821 |
Dysarthria | 33.47 | 11.20 | 133 | 59714 | 34649 | 34862435 |
Electroencephalogram abnormal | 32.93 | 11.20 | 30 | 59817 | 2448 | 34894636 |
Sedation complication | 32.83 | 11.20 | 26 | 59821 | 1751 | 34895333 |
Product prescribing error | 32.80 | 11.20 | 100 | 59747 | 22827 | 34874257 |
Memory impairment | 32.74 | 11.20 | 154 | 59693 | 43164 | 34853920 |
Epistaxis | 32.55 | 11.20 | 31 | 59816 | 58220 | 34838864 |
Pleural effusion | 32.51 | 11.20 | 56 | 59791 | 81490 | 34815594 |
Central nervous system infection | 32.46 | 11.20 | 18 | 59829 | 662 | 34896422 |
Macrophages increased | 32.25 | 11.20 | 12 | 59835 | 168 | 34896916 |
Alcohol poisoning | 32.01 | 11.20 | 35 | 59812 | 3558 | 34893526 |
Drug delivery device placement | 31.88 | 11.20 | 11 | 59836 | 122 | 34896962 |
Generalised tonic-clonic seizure | 31.85 | 11.20 | 94 | 59753 | 21080 | 34876004 |
Accidental overdose | 31.82 | 11.20 | 91 | 59756 | 20049 | 34877035 |
Foetal exposure during pregnancy | 31.28 | 11.20 | 13 | 59834 | 38088 | 34858996 |
Purulent discharge | 31.09 | 11.20 | 31 | 59816 | 2832 | 34894252 |
Apnoea | 30.96 | 11.20 | 47 | 59800 | 6617 | 34890467 |
Anal incontinence | 30.47 | 11.20 | 51 | 59796 | 7798 | 34889286 |
Myocardial infarction | 30.29 | 11.20 | 106 | 59741 | 120979 | 34776105 |
Metabolic encephalopathy | 30.17 | 11.20 | 37 | 59810 | 4255 | 34892829 |
Implant site reaction | 29.96 | 11.20 | 8 | 59839 | 33 | 34897051 |
Pneumonia | 29.62 | 11.20 | 440 | 59407 | 362187 | 34534897 |
CSF culture positive | 29.61 | 11.20 | 7 | 59840 | 15 | 34897069 |
Decreased appetite | 29.34 | 11.20 | 166 | 59681 | 166226 | 34730858 |
Pollakiuria | 29.26 | 11.20 | 87 | 59760 | 19587 | 34877497 |
Depression | 29.26 | 11.20 | 274 | 59573 | 96824 | 34800260 |
Lipoma | 29.23 | 11.20 | 24 | 59823 | 1702 | 34895382 |
Device programming error | 29.14 | 11.20 | 9 | 59838 | 68 | 34897016 |
Muscle rigidity | 29.04 | 11.20 | 59 | 59788 | 10459 | 34886625 |
White blood cells urine positive | 28.48 | 11.20 | 21 | 59826 | 1271 | 34895813 |
Stomatitis | 28.29 | 11.20 | 19 | 59828 | 42495 | 34854589 |
Gait inability | 28.27 | 11.20 | 89 | 59758 | 20669 | 34876415 |
Seroma | 28.21 | 11.20 | 16 | 59831 | 615 | 34896469 |
Device extrusion | 28.08 | 11.20 | 6 | 59841 | 6 | 34897078 |
Hepatic function abnormal | 27.98 | 11.20 | 21 | 59826 | 44342 | 34852742 |
Seronegative arthritis | 27.78 | 11.20 | 19 | 59828 | 1020 | 34896064 |
Implant site mass | 27.60 | 11.20 | 6 | 59841 | 7 | 34897077 |
Multiple organ dysfunction syndrome | 27.50 | 11.20 | 56 | 59791 | 76510 | 34820574 |
Device inversion | 26.86 | 11.20 | 5 | 59842 | 0 | 34897084 |
Rectal haemorrhage | 26.77 | 11.20 | 18 | 59829 | 40231 | 34856853 |
Meningitis | 26.62 | 11.20 | 37 | 59810 | 4810 | 34892274 |
Monocyte percentage increased | 26.58 | 11.20 | 18 | 59829 | 951 | 34896133 |
Ascites | 25.76 | 11.20 | 25 | 59822 | 46546 | 34850538 |
Haemorrhage | 25.71 | 11.20 | 30 | 59817 | 51340 | 34845744 |
White blood cell count decreased | 25.62 | 11.20 | 81 | 59766 | 95364 | 34801720 |
Delirium tremens | 25.57 | 11.20 | 15 | 59832 | 615 | 34896469 |
Epilepsy | 25.54 | 11.20 | 88 | 59759 | 21407 | 34875677 |
Motor dysfunction | 25.34 | 11.20 | 44 | 59803 | 6930 | 34890154 |
Child abuse | 25.15 | 11.20 | 13 | 59834 | 414 | 34896670 |
Posturing | 25.12 | 11.20 | 14 | 59833 | 520 | 34896564 |
Weight decreased | 24.94 | 11.20 | 188 | 59659 | 176113 | 34720971 |
Performance status decreased | 24.87 | 11.20 | 33 | 59814 | 4104 | 34892980 |
Suicide attempt | 24.58 | 11.20 | 132 | 59715 | 38984 | 34858100 |
Hyperhidrosis | 24.53 | 11.20 | 217 | 59630 | 75475 | 34821609 |
Pseudomeningocele | 24.51 | 11.20 | 5 | 59842 | 3 | 34897081 |
Areflexia | 24.39 | 11.20 | 28 | 59819 | 3003 | 34894081 |
Oedema peripheral | 24.23 | 11.20 | 114 | 59733 | 119698 | 34777386 |
Patient-device incompatibility | 24.20 | 11.20 | 6 | 59841 | 17 | 34897067 |
Neutrophil percentage increased | 23.98 | 11.20 | 22 | 59825 | 1811 | 34895273 |
Anxiety | 23.94 | 11.20 | 268 | 59579 | 99160 | 34797924 |
Implant site oedema | 23.93 | 11.20 | 5 | 59842 | 4 | 34897080 |
Infusion site granuloma | 23.93 | 11.20 | 5 | 59842 | 4 | 34897080 |
Hallucination | 23.56 | 11.20 | 160 | 59687 | 51338 | 34845746 |
Weight increased | 23.56 | 11.20 | 81 | 59766 | 92952 | 34804132 |
Miosis | 23.43 | 11.20 | 51 | 59796 | 9484 | 34887600 |
Bradycardia | 23.30 | 11.20 | 214 | 59633 | 75204 | 34821880 |
Device leakage | 23.26 | 11.20 | 41 | 59806 | 6534 | 34890550 |
Staphylococcus test positive | 23.26 | 11.20 | 28 | 59819 | 3158 | 34893926 |
Cytomegalovirus infection | 22.98 | 11.20 | 8 | 59839 | 26127 | 34870957 |
Jaundice | 22.95 | 11.20 | 13 | 59834 | 31869 | 34865215 |
Chronic kidney disease | 22.94 | 11.20 | 22 | 59825 | 41188 | 34855896 |
Implant site dehiscence | 22.93 | 11.20 | 8 | 59839 | 92 | 34896992 |
Paralysis | 22.92 | 11.20 | 39 | 59808 | 6043 | 34891041 |
Myelosuppression | 22.80 | 11.20 | 3 | 59844 | 19262 | 34877822 |
Electric shock | 22.76 | 11.20 | 9 | 59838 | 150 | 34896934 |
Mobility decreased | 22.68 | 11.20 | 107 | 59740 | 30021 | 34867063 |
Coma scale abnormal | 22.62 | 11.20 | 31 | 59816 | 3977 | 34893107 |
Cystitis | 22.61 | 11.20 | 51 | 59796 | 9714 | 34887370 |
Bone marrow failure | 22.42 | 11.20 | 11 | 59836 | 29242 | 34867842 |
Haematochezia | 22.41 | 11.20 | 28 | 59819 | 46506 | 34850578 |
Bacterial test positive | 22.28 | 11.20 | 27 | 59820 | 3066 | 34894018 |
Hypoglycaemia | 22.25 | 11.20 | 37 | 59810 | 54603 | 34842481 |
Device material issue | 22.23 | 11.20 | 6 | 59841 | 26 | 34897058 |
Nocturia | 22.18 | 11.20 | 52 | 59795 | 10158 | 34886926 |
Asphyxia | 22.12 | 11.20 | 41 | 59806 | 6794 | 34890290 |
Toxic epidermal necrolysis | 22.05 | 11.20 | 5 | 59842 | 21641 | 34875443 |
Magnetic resonance imaging abnormal | 21.91 | 11.20 | 20 | 59827 | 1636 | 34895448 |
Muscle contractions involuntary | 21.84 | 11.20 | 21 | 59826 | 1835 | 34895249 |
JC polyomavirus test positive | 21.67 | 11.20 | 14 | 59833 | 683 | 34896401 |
Medical device site extravasation | 21.49 | 11.20 | 4 | 59843 | 0 | 34897084 |
Catheter site erosion | 21.49 | 11.20 | 4 | 59843 | 0 | 34897084 |
Infusion site fibrosis | 21.49 | 11.20 | 4 | 59843 | 0 | 34897084 |
Influenza like illness | 21.43 | 11.20 | 99 | 59748 | 27535 | 34869549 |
Incorrect drug administration rate | 21.41 | 11.20 | 20 | 59827 | 1685 | 34895399 |
Pneumocystis jirovecii pneumonia | 21.22 | 11.20 | 4 | 59843 | 19706 | 34877378 |
Chest pain | 20.98 | 11.20 | 129 | 59718 | 126633 | 34770451 |
Erectile dysfunction | 20.73 | 11.20 | 80 | 59767 | 20557 | 34876527 |
Neutrophil count decreased | 20.45 | 11.20 | 35 | 59812 | 51069 | 34846015 |
Hypocalcaemia | 20.41 | 11.20 | 8 | 59839 | 24281 | 34872803 |
Dysgeusia | 20.25 | 11.20 | 10 | 59837 | 26487 | 34870597 |
Pneumonitis | 20.15 | 11.20 | 17 | 59830 | 33861 | 34863223 |
Lymphadenopathy | 19.92 | 11.20 | 12 | 59835 | 28451 | 34868633 |
Hepatotoxicity | 19.91 | 11.20 | 6 | 59841 | 21479 | 34875605 |
Respiratory acidosis | 19.85 | 11.20 | 33 | 59814 | 5017 | 34892067 |
Alcohol withdrawal syndrome | 19.77 | 11.20 | 18 | 59829 | 1468 | 34895616 |
Angina pectoris | 19.58 | 11.20 | 15 | 59832 | 31348 | 34865736 |
Hallucination, visual | 19.56 | 11.20 | 71 | 59776 | 17720 | 34879364 |
Drug resistance | 19.49 | 11.20 | 10 | 59837 | 25917 | 34871167 |
Drug eruption | 19.48 | 11.20 | 5 | 59842 | 19893 | 34877191 |
Coronary artery disease | 19.40 | 11.20 | 33 | 59814 | 48272 | 34848812 |
Medical device site ulcer | 19.25 | 11.20 | 4 | 59843 | 3 | 34897081 |
Liver disorder | 19.09 | 11.20 | 17 | 59830 | 32980 | 34864104 |
Intestinal pseudo-obstruction | 19.04 | 11.20 | 19 | 59828 | 1737 | 34895347 |
Pre-existing disease | 18.95 | 11.20 | 7 | 59840 | 96 | 34896988 |
Cognitive disorder | 18.83 | 11.20 | 98 | 59749 | 28595 | 34868489 |
Brain injury | 18.83 | 11.20 | 36 | 59811 | 6106 | 34890978 |
General symptom | 18.66 | 11.20 | 14 | 59833 | 870 | 34896214 |
Chest discomfort | 18.64 | 11.20 | 41 | 59806 | 54489 | 34842595 |
Posture abnormal | 18.55 | 11.20 | 21 | 59826 | 2218 | 34894866 |
Urine leukocyte esterase positive | 18.55 | 11.20 | 11 | 59836 | 460 | 34896624 |
Agranulocytosis | 18.19 | 11.20 | 9 | 59838 | 23812 | 34873272 |
Irritability | 18.09 | 11.20 | 87 | 59760 | 24603 | 34872481 |
Peroneal nerve palsy | 18.07 | 11.20 | 24 | 59823 | 2987 | 34894097 |
Drug reaction with eosinophilia and systemic symptoms | 17.94 | 11.20 | 18 | 59829 | 32994 | 34864090 |
Dehydration | 17.70 | 11.20 | 140 | 59707 | 129829 | 34767255 |
Proteinuria | 17.65 | 11.20 | 5 | 59842 | 18637 | 34878447 |
Decreased vibratory sense | 17.62 | 11.20 | 10 | 59837 | 385 | 34896699 |
Therapeutic response unexpected | 17.31 | 11.20 | 46 | 59801 | 9711 | 34887373 |
Tumour lysis syndrome | 17.26 | 11.20 | 4 | 59843 | 17055 | 34880029 |
Euphoric mood | 17.21 | 11.20 | 33 | 59814 | 5608 | 34891476 |
Hypoventilation | 17.18 | 11.20 | 25 | 59822 | 3389 | 34893695 |
Hyporeflexia | 17.09 | 11.20 | 19 | 59828 | 1968 | 34895116 |
Hypomagnesaemia | 17.08 | 11.20 | 8 | 59839 | 21843 | 34875241 |
Road traffic accident | 17.00 | 11.20 | 67 | 59780 | 17383 | 34879701 |
Wound infection staphylococcal | 16.96 | 11.20 | 16 | 59831 | 1365 | 34895719 |
Haemoglobin decreased | 16.96 | 11.20 | 129 | 59718 | 120643 | 34776441 |
Amnesia | 16.93 | 11.20 | 90 | 59757 | 26473 | 34870611 |
Colitis | 16.87 | 11.20 | 24 | 59823 | 37726 | 34859358 |
Gout | 16.75 | 11.20 | 6 | 59841 | 19247 | 34877837 |
Blood ketone body increased | 16.55 | 11.20 | 10 | 59837 | 433 | 34896651 |
Brief psychotic disorder with marked stressors | 16.45 | 11.20 | 8 | 59839 | 223 | 34896861 |
Muscle contracture | 16.41 | 11.20 | 15 | 59832 | 1229 | 34895855 |
Asthma | 16.35 | 11.20 | 30 | 59817 | 42626 | 34854458 |
Neuralgia | 16.35 | 11.20 | 60 | 59787 | 15053 | 34882031 |
Dysstasia | 16.34 | 11.20 | 52 | 59795 | 12143 | 34884941 |
Discomfort | 16.31 | 11.20 | 70 | 59777 | 18868 | 34878216 |
Glossopharyngeal nerve disorder | 16.17 | 11.20 | 5 | 59842 | 38 | 34897046 |
Tachyphrenia | 16.16 | 11.20 | 15 | 59832 | 1254 | 34895830 |
Implant site ulcer | 16.12 | 11.20 | 3 | 59844 | 0 | 34897084 |
Medical device site oedema | 16.12 | 11.20 | 3 | 59844 | 0 | 34897084 |
Neuromuscular blocking therapy | 16.12 | 11.20 | 3 | 59844 | 0 | 34897084 |
Device deposit issue | 16.12 | 11.20 | 3 | 59844 | 0 | 34897084 |
Incision site vesicles | 16.12 | 11.20 | 3 | 59844 | 0 | 34897084 |
Unevaluable event | 15.96 | 11.20 | 103 | 59744 | 32487 | 34864597 |
Haemoptysis | 15.90 | 11.20 | 22 | 59825 | 34984 | 34862100 |
Bladder dysfunction | 15.89 | 11.20 | 9 | 59838 | 345 | 34896739 |
Arrhythmia | 15.77 | 11.20 | 23 | 59824 | 35785 | 34861299 |
Bronchopulmonary aspergillosis | 15.73 | 11.20 | 3 | 59844 | 14656 | 34882428 |
Narcissistic personality disorder | 15.72 | 11.20 | 4 | 59843 | 13 | 34897071 |
Anaphylactic shock | 15.62 | 11.20 | 4 | 59843 | 15937 | 34881147 |
Hallucinations, mixed | 15.48 | 11.20 | 21 | 59826 | 2668 | 34894416 |
Influenza B virus test positive | 15.40 | 11.20 | 6 | 59841 | 96 | 34896988 |
Blood ethanol increased | 15.38 | 11.20 | 10 | 59837 | 493 | 34896591 |
Neuropathy peripheral | 15.24 | 11.20 | 82 | 59765 | 83181 | 34813903 |
Axillary pain | 15.23 | 11.20 | 9 | 59838 | 374 | 34896710 |
International normalised ratio increased | 15.04 | 11.20 | 37 | 59810 | 47290 | 34849794 |
Bladder disorder | 14.92 | 11.20 | 23 | 59824 | 3281 | 34893803 |
Band neutrophil percentage increased | 14.90 | 11.20 | 6 | 59841 | 105 | 34896979 |
Scar | 14.84 | 11.20 | 32 | 59815 | 5912 | 34891172 |
Implant site inflammation | 14.80 | 11.20 | 6 | 59841 | 107 | 34896977 |
Scratch | 14.69 | 11.20 | 23 | 59824 | 3325 | 34893759 |
Postoperative delirium | 14.64 | 11.20 | 7 | 59840 | 188 | 34896896 |
Blood sodium increased | 14.54 | 11.20 | 21 | 59826 | 2827 | 34894257 |
Tethered cord syndrome | 14.52 | 11.20 | 4 | 59843 | 19 | 34897065 |
Pulmonary hypertension | 14.40 | 11.20 | 9 | 59838 | 20915 | 34876169 |
Melaena | 14.36 | 11.20 | 24 | 59823 | 35356 | 34861728 |
Cholestasis | 14.29 | 11.20 | 15 | 59832 | 26933 | 34870151 |
Hallucination, olfactory | 14.27 | 11.20 | 7 | 59840 | 199 | 34896885 |
Drug-induced liver injury | 14.25 | 11.20 | 17 | 59830 | 28815 | 34868269 |
Hepatitis | 14.21 | 11.20 | 12 | 59835 | 23892 | 34873192 |
Exaggerated startle response | 14.19 | 11.20 | 4 | 59843 | 21 | 34897063 |
Loss of control of legs | 14.14 | 11.20 | 11 | 59836 | 722 | 34896362 |
Polyneuropathy | 14.10 | 11.20 | 4 | 59843 | 14892 | 34882192 |
Medical device site warmth | 14.04 | 11.20 | 3 | 59844 | 3 | 34897081 |
Product use in unapproved indication | 14.02 | 11.20 | 131 | 59716 | 117368 | 34779716 |
Staphylococcal infection | 13.93 | 11.20 | 100 | 59747 | 32660 | 34864424 |
Acute myeloid leukaemia | 13.80 | 11.20 | 7 | 59840 | 18263 | 34878821 |
Contraindicated product administered | 13.76 | 11.20 | 10 | 59837 | 21471 | 34875613 |
Blood bilirubin increased | 13.75 | 11.20 | 28 | 59819 | 38268 | 34858816 |
C-reactive protein increased | 13.75 | 11.20 | 47 | 59800 | 54051 | 34843033 |
Mental status changes postoperative | 13.58 | 11.20 | 3 | 59844 | 4 | 34897080 |
Pancreatitis | 13.49 | 11.20 | 29 | 59818 | 38862 | 34858222 |
Eosinophilia | 13.46 | 11.20 | 15 | 59832 | 26207 | 34870877 |
Medical device site haemorrhage | 13.44 | 11.20 | 6 | 59841 | 137 | 34896947 |
Red blood cells urine positive | 13.37 | 11.20 | 16 | 59831 | 1793 | 34895291 |
Palmar-plantar erythrodysaesthesia syndrome | 13.36 | 11.20 | 6 | 59841 | 16789 | 34880295 |
Loss of consciousness | 13.27 | 11.20 | 207 | 59640 | 82460 | 34814624 |
CD8 lymphocytes increased | 13.22 | 11.20 | 4 | 59843 | 28 | 34897056 |
Rash pruritic | 13.19 | 11.20 | 16 | 59831 | 26925 | 34870159 |
Procedural complication | 13.00 | 11.20 | 25 | 59822 | 4258 | 34892826 |
Mental disorder | 12.93 | 11.20 | 56 | 59791 | 15153 | 34881931 |
Streptococcus test positive | 12.93 | 11.20 | 12 | 59835 | 1003 | 34896081 |
Burning sensation | 12.89 | 11.20 | 64 | 59783 | 18330 | 34878754 |
Adrenal insufficiency | 12.88 | 11.20 | 4 | 59843 | 14043 | 34883041 |
Spinal cord injury cauda equina | 12.87 | 11.20 | 6 | 59841 | 152 | 34896932 |
Erythema | 12.85 | 11.20 | 94 | 59753 | 88686 | 34808398 |
Ulcerative duodenitis | 12.83 | 11.20 | 3 | 59844 | 6 | 34897078 |
Implant site rash | 12.83 | 11.20 | 3 | 59844 | 6 | 34897078 |
Pituitary cyst | 12.83 | 11.20 | 3 | 59844 | 6 | 34897078 |
Urine cannabinoids increased | 12.83 | 11.20 | 3 | 59844 | 6 | 34897078 |
Rash maculo-papular | 12.80 | 11.20 | 18 | 59829 | 28433 | 34868651 |
Feeling of body temperature change | 12.80 | 11.20 | 14 | 59833 | 1424 | 34895660 |
Ventricular tachycardia | 12.79 | 11.20 | 16 | 59831 | 26563 | 34870521 |
Chronic obstructive pulmonary disease | 12.78 | 11.20 | 42 | 59805 | 48876 | 34848208 |
Hypothermia | 12.77 | 11.20 | 44 | 59803 | 10704 | 34886380 |
Poor quality sleep | 12.74 | 11.20 | 37 | 59810 | 8219 | 34888865 |
Drug ineffective | 12.73 | 11.20 | 646 | 59201 | 456105 | 34440979 |
Mydriasis | 12.72 | 11.20 | 34 | 59813 | 7203 | 34889881 |
Hiccups | 12.61 | 11.20 | 42 | 59805 | 10040 | 34887044 |
Logorrhoea | 12.55 | 11.20 | 18 | 59829 | 2408 | 34894676 |
CSF shunt operation | 12.52 | 11.20 | 3 | 59844 | 7 | 34897077 |
Uhthoff's phenomenon | 12.52 | 11.20 | 3 | 59844 | 7 | 34897077 |
Stitch abscess | 12.52 | 11.20 | 3 | 59844 | 7 | 34897077 |
Hyperglycaemia | 12.44 | 11.20 | 31 | 59816 | 39449 | 34857635 |
Somatosensory evoked potentials abnormal | 12.41 | 11.20 | 6 | 59841 | 165 | 34896919 |
Haematuria | 12.39 | 11.20 | 44 | 59803 | 50022 | 34847062 |
Myocarditis | 12.36 | 11.20 | 4 | 59843 | 13678 | 34883406 |
Systolic hypertension | 12.34 | 11.20 | 7 | 59840 | 269 | 34896815 |
Treatment failure | 12.26 | 11.20 | 40 | 59807 | 46657 | 34850427 |
Arthralgia | 12.26 | 11.20 | 211 | 59636 | 169830 | 34727254 |
Appendicitis | 12.24 | 11.20 | 5 | 59842 | 14802 | 34882282 |
Spinal cord infection | 12.12 | 11.20 | 6 | 59841 | 174 | 34896910 |
Proteus test positive | 12.09 | 11.20 | 5 | 59842 | 94 | 34896990 |
Wound | 12.08 | 11.20 | 54 | 59793 | 14810 | 34882274 |
Postoperative wound infection | 12.07 | 11.20 | 26 | 59821 | 4800 | 34892284 |
Spinal cord injury | 12.06 | 11.20 | 9 | 59838 | 555 | 34896529 |
Scoliosis | 12.00 | 11.20 | 19 | 59828 | 2774 | 34894310 |
Grimacing | 11.95 | 11.20 | 7 | 59840 | 286 | 34896798 |
Septic shock | 11.93 | 11.20 | 73 | 59774 | 71761 | 34825323 |
Upper respiratory tract irritation | 11.88 | 11.20 | 4 | 59843 | 41 | 34897043 |
Post laminectomy syndrome | 11.84 | 11.20 | 6 | 59841 | 183 | 34896901 |
Primary progressive multiple sclerosis | 11.71 | 11.20 | 4 | 59843 | 43 | 34897041 |
Abdominal pain upper | 11.69 | 11.20 | 73 | 59774 | 71417 | 34825667 |
Productive cough | 11.67 | 11.20 | 30 | 59817 | 37783 | 34859301 |
Temperature intolerance | 11.67 | 11.20 | 21 | 59826 | 3401 | 34893683 |
Quadriplegia | 11.65 | 11.20 | 15 | 59832 | 1812 | 34895272 |
Obstructive airways disorder | 11.61 | 11.20 | 6 | 59841 | 15488 | 34881596 |
Patella fracture | 11.57 | 11.20 | 7 | 59840 | 304 | 34896780 |
Excessive granulation tissue | 11.53 | 11.20 | 8 | 59839 | 440 | 34896644 |
Analgesic drug level above therapeutic | 11.53 | 11.20 | 7 | 59840 | 306 | 34896778 |
Duodenitis haemorrhagic | 11.45 | 11.20 | 5 | 59842 | 108 | 34896976 |
Intentional product use issue | 11.45 | 11.20 | 58 | 59789 | 59758 | 34837326 |
Cardiotoxicity | 11.44 | 11.20 | 28 | 59819 | 5620 | 34891464 |
Conduction disorder | 11.43 | 11.20 | 16 | 59831 | 2094 | 34894990 |
Vitamin B6 deficiency | 11.38 | 11.20 | 6 | 59841 | 199 | 34896885 |
Musculoskeletal discomfort | 11.36 | 11.20 | 35 | 59812 | 8033 | 34889051 |
Glomerular filtration rate decreased | 11.34 | 11.20 | 4 | 59843 | 12957 | 34884127 |
Blood pressure fluctuation | 11.33 | 11.20 | 16 | 59831 | 25233 | 34871851 |
Myalgia | 11.26 | 11.20 | 91 | 59756 | 84019 | 34813065 |
Therapeutic response changed | 11.24 | 11.20 | 8 | 59839 | 458 | 34896626 |
Neoplasm progression | 11.24 | 11.20 | 14 | 59833 | 23286 | 34873798 |
Incision site swelling | 11.24 | 11.20 | 4 | 59843 | 49 | 34897035 |
Bladder cancer | 11.20 | 11.20 | 7 | 59840 | 16271 | 34880813 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug withdrawal syndrome | 2167.52 | 10.13 | 1088 | 131634 | 33630 | 79578036 |
Multiple sclerosis relapse | 1628.57 | 10.13 | 996 | 131726 | 45537 | 79566129 |
Muscle spasticity | 1351.59 | 10.13 | 677 | 132045 | 20798 | 79590868 |
Multiple sclerosis | 1066.88 | 10.13 | 585 | 132137 | 21697 | 79589969 |
Implant site infection | 846.14 | 10.13 | 249 | 132473 | 1616 | 79610050 |
Implant site extravasation | 814.22 | 10.13 | 203 | 132519 | 616 | 79611050 |
Coma | 707.98 | 10.13 | 855 | 131867 | 99794 | 79511872 |
Device failure | 529.75 | 10.13 | 242 | 132480 | 6019 | 79605647 |
Urinary tract infection | 488.80 | 10.13 | 1271 | 131451 | 273241 | 79338425 |
Overdose | 441.70 | 10.13 | 958 | 131764 | 183248 | 79428418 |
Muscle spasms | 437.67 | 10.13 | 925 | 131797 | 173805 | 79437861 |
Somnolence | 437.14 | 10.13 | 1118 | 131604 | 237863 | 79373803 |
Hypotonia | 430.79 | 10.13 | 268 | 132454 | 12602 | 79599064 |
Completed suicide | 407.01 | 10.13 | 1108 | 131614 | 244659 | 79367007 |
Mental status changes | 396.13 | 10.13 | 522 | 132200 | 66437 | 79545229 |
Cerebrospinal fluid leakage | 366.71 | 10.13 | 129 | 132593 | 1570 | 79610096 |
Hypertonia | 357.46 | 10.13 | 194 | 132528 | 7038 | 79604628 |
Device infusion issue | 313.27 | 10.13 | 125 | 132597 | 2201 | 79609465 |
Seizure | 306.09 | 10.13 | 845 | 131877 | 187989 | 79423677 |
Complication associated with device | 301.86 | 10.13 | 243 | 132479 | 17253 | 79594413 |
Unresponsive to stimuli | 275.94 | 10.13 | 399 | 132323 | 55389 | 79556277 |
Withdrawal syndrome | 265.92 | 10.13 | 273 | 132449 | 26581 | 79585085 |
Toxicity to various agents | 263.75 | 10.13 | 1390 | 131332 | 420150 | 79191516 |
Fall | 250.43 | 10.13 | 1525 | 131197 | 486104 | 79125562 |
Pneumonia aspiration | 241.07 | 10.13 | 414 | 132308 | 66553 | 79545113 |
Gait disturbance | 240.51 | 10.13 | 826 | 131896 | 206680 | 79404986 |
Medical device site infection | 236.24 | 10.13 | 71 | 132651 | 500 | 79611166 |
Febrile neutropenia | 232.89 | 10.13 | 50 | 132672 | 230949 | 79380717 |
Respiratory depression | 226.24 | 10.13 | 254 | 132468 | 27376 | 79584290 |
Muscular weakness | 218.82 | 10.13 | 676 | 132046 | 160053 | 79451613 |
Muscle tightness | 215.67 | 10.13 | 176 | 132546 | 12738 | 79598928 |
Device physical property issue | 204.85 | 10.13 | 96 | 132626 | 2534 | 79609132 |
Implant site erosion | 198.95 | 10.13 | 49 | 132673 | 139 | 79611527 |
Device kink | 198.17 | 10.13 | 85 | 132637 | 1810 | 79609856 |
Anaemia | 196.01 | 10.13 | 273 | 132449 | 444742 | 79166924 |
Medical device site discharge | 191.94 | 10.13 | 39 | 132683 | 24 | 79611642 |
Medical device site pain | 190.87 | 10.13 | 53 | 132669 | 270 | 79611396 |
Implant site swelling | 188.85 | 10.13 | 57 | 132665 | 408 | 79611258 |
Device power source issue | 188.47 | 10.13 | 68 | 132654 | 895 | 79610771 |
Toxic encephalopathy | 182.86 | 10.13 | 152 | 132570 | 11288 | 79600378 |
Therapy non-responder | 177.98 | 10.13 | 441 | 132281 | 91864 | 79519802 |
Encephalopathy | 176.88 | 10.13 | 364 | 132358 | 67033 | 79544633 |
Implant site discharge | 176.58 | 10.13 | 44 | 132678 | 133 | 79611533 |
Medical device site swelling | 174.25 | 10.13 | 38 | 132684 | 48 | 79611618 |
Diarrhoea | 163.99 | 10.13 | 832 | 131890 | 879657 | 78732009 |
Medical device site erythema | 163.98 | 10.13 | 36 | 132686 | 48 | 79611618 |
Pocket erosion | 163.37 | 10.13 | 32 | 132690 | 11 | 79611655 |
Central nervous system lesion | 158.56 | 10.13 | 150 | 132572 | 13218 | 79598448 |
Neurotoxicity | 155.57 | 10.13 | 229 | 132493 | 32289 | 79579377 |
Decubitus ulcer | 154.43 | 10.13 | 159 | 132563 | 15528 | 79596138 |
Wound dehiscence | 152.23 | 10.13 | 109 | 132613 | 6486 | 79605180 |
Neutropenia | 148.28 | 10.13 | 156 | 132566 | 287554 | 79324112 |
Hypoaesthesia | 146.30 | 10.13 | 639 | 132083 | 178713 | 79432953 |
Rash | 135.89 | 10.13 | 500 | 132222 | 577858 | 79033808 |
Contraindicated product administered | 134.58 | 10.13 | 47 | 132675 | 157491 | 79454175 |
Pericarditis | 132.24 | 10.13 | 11 | 132711 | 104225 | 79507441 |
Infusion related reaction | 131.26 | 10.13 | 114 | 132608 | 230123 | 79381543 |
Glossodynia | 130.84 | 10.13 | 11 | 132711 | 103326 | 79508340 |
Implant site pain | 128.59 | 10.13 | 65 | 132657 | 2032 | 79609634 |
Secondary progressive multiple sclerosis | 127.70 | 10.13 | 57 | 132665 | 1340 | 79610326 |
Tremor | 126.73 | 10.13 | 590 | 132132 | 169493 | 79442173 |
Gait spastic | 126.19 | 10.13 | 54 | 132668 | 1143 | 79610523 |
Synovitis | 123.65 | 10.13 | 48 | 132674 | 150686 | 79460980 |
Clonus | 122.23 | 10.13 | 97 | 132625 | 6743 | 79604923 |
Sedation | 121.96 | 10.13 | 268 | 132454 | 51627 | 79560039 |
Device malfunction | 120.30 | 10.13 | 163 | 132559 | 21285 | 79590381 |
Status epilepticus | 117.84 | 10.13 | 175 | 132547 | 24866 | 79586800 |
Memory impairment | 116.63 | 10.13 | 430 | 132292 | 111304 | 79500362 |
Systemic lupus erythematosus | 116.51 | 10.13 | 29 | 132693 | 121120 | 79490546 |
Urinary incontinence | 115.74 | 10.13 | 228 | 132494 | 40681 | 79570985 |
Arthropathy | 114.59 | 10.13 | 77 | 132645 | 177034 | 79434632 |
Balance disorder | 113.92 | 10.13 | 393 | 132329 | 98464 | 79513202 |
Malignant neoplasm progression | 110.40 | 10.13 | 44 | 132678 | 135946 | 79475720 |
Pancytopenia | 110.02 | 10.13 | 70 | 132652 | 165675 | 79445991 |
Interstitial lung disease | 108.19 | 10.13 | 27 | 132695 | 112573 | 79499093 |
Joint swelling | 108.10 | 10.13 | 197 | 132525 | 288449 | 79323217 |
Underdose | 107.70 | 10.13 | 196 | 132526 | 32955 | 79578711 |
Thrombocytopenia | 107.62 | 10.13 | 172 | 132550 | 265087 | 79346579 |
Device alarm issue | 105.91 | 10.13 | 57 | 132665 | 2032 | 79609634 |
Hand deformity | 105.68 | 10.13 | 22 | 132700 | 103897 | 79507769 |
Acute kidney injury | 105.01 | 10.13 | 476 | 132246 | 518928 | 79092738 |
Relapsing-remitting multiple sclerosis | 104.76 | 10.13 | 51 | 132671 | 1468 | 79610198 |
Dyspnoea | 104.36 | 10.13 | 919 | 131803 | 856106 | 78755560 |
Progressive multiple sclerosis | 102.82 | 10.13 | 47 | 132675 | 1170 | 79610496 |
Post lumbar puncture syndrome | 102.63 | 10.13 | 41 | 132681 | 724 | 79610942 |
Agitation | 101.77 | 10.13 | 381 | 132341 | 99334 | 79512332 |
Device dislocation | 100.65 | 10.13 | 166 | 132556 | 25804 | 79585862 |
Neurogenic bladder | 100.41 | 10.13 | 71 | 132651 | 4141 | 79607525 |
Intracranial hypotension | 99.09 | 10.13 | 34 | 132688 | 382 | 79611284 |
Helicobacter infection | 98.59 | 10.13 | 4 | 132718 | 69700 | 79541966 |
Needle fatigue | 96.11 | 10.13 | 41 | 132681 | 861 | 79610805 |
Lethargy | 95.25 | 10.13 | 325 | 132397 | 80967 | 79530699 |
Trigeminal neuralgia | 93.45 | 10.13 | 64 | 132658 | 3545 | 79608121 |
Cardiac failure | 92.76 | 10.13 | 73 | 132649 | 154769 | 79456897 |
Duodenal ulcer perforation | 89.78 | 10.13 | 5 | 132717 | 66206 | 79545460 |
Urine analysis abnormal | 88.70 | 10.13 | 79 | 132643 | 6441 | 79605225 |
Abdominal discomfort | 86.16 | 10.13 | 180 | 132542 | 250547 | 79361119 |
Intentional overdose | 85.17 | 10.13 | 376 | 132346 | 105584 | 79506082 |
Device connection issue | 83.93 | 10.13 | 39 | 132683 | 1009 | 79610657 |
Atrial fibrillation | 83.41 | 10.13 | 125 | 132597 | 197761 | 79413905 |
Dystonia | 83.22 | 10.13 | 137 | 132585 | 21262 | 79590404 |
Asphyxia | 81.35 | 10.13 | 99 | 132623 | 11621 | 79600045 |
Medical device site fibrosis | 81.32 | 10.13 | 16 | 132706 | 6 | 79611660 |
Ataxia | 81.28 | 10.13 | 148 | 132574 | 24891 | 79586775 |
Lymphocyte count decreased | 79.84 | 10.13 | 215 | 132507 | 47074 | 79564592 |
Drug intolerance | 79.18 | 10.13 | 204 | 132518 | 263915 | 79347751 |
General physical health deterioration | 79.17 | 10.13 | 217 | 132505 | 275021 | 79336645 |
Mucosal inflammation | 78.94 | 10.13 | 15 | 132707 | 75565 | 79536101 |
Depressed level of consciousness | 78.46 | 10.13 | 344 | 132378 | 96308 | 79515358 |
Device issue | 77.78 | 10.13 | 152 | 132570 | 26956 | 79584710 |
Exposure during pregnancy | 76.86 | 10.13 | 36 | 132686 | 101096 | 79510570 |
Progressive multifocal leukoencephalopathy | 76.26 | 10.13 | 129 | 132593 | 20471 | 79591195 |
Implant site erythema | 76.03 | 10.13 | 30 | 132692 | 512 | 79611154 |
Medical device site erosion | 75.90 | 10.13 | 18 | 132704 | 41 | 79611625 |
Device inversion | 75.60 | 10.13 | 14 | 132708 | 0 | 79611666 |
Urosepsis | 75.34 | 10.13 | 148 | 132574 | 26347 | 79585319 |
Maternal exposure during pregnancy | 74.91 | 10.13 | 70 | 132652 | 136468 | 79475198 |
Infusion site mass | 73.94 | 10.13 | 41 | 132681 | 1552 | 79610114 |
Muscle rigidity | 72.93 | 10.13 | 124 | 132598 | 19758 | 79591908 |
Renal impairment | 72.14 | 10.13 | 94 | 132628 | 157689 | 79453977 |
Confusional state | 70.37 | 10.13 | 824 | 131898 | 317173 | 79294493 |
Metabolic encephalopathy | 69.64 | 10.13 | 81 | 132641 | 9066 | 79602600 |
Bradypnoea | 68.15 | 10.13 | 66 | 132656 | 5986 | 79605680 |
Therapeutic response decreased | 67.83 | 10.13 | 255 | 132467 | 66598 | 79545068 |
Laboratory test abnormal | 67.20 | 10.13 | 146 | 132576 | 27902 | 79583764 |
Folliculitis | 67.15 | 10.13 | 7 | 132715 | 55373 | 79556293 |
Platelet count decreased | 66.65 | 10.13 | 140 | 132582 | 194524 | 79417142 |
Electroencephalogram abnormal | 66.41 | 10.13 | 62 | 132660 | 5372 | 79606294 |
Rheumatoid arthritis | 66.40 | 10.13 | 156 | 132566 | 208314 | 79403352 |
Neuralgia | 65.89 | 10.13 | 161 | 132561 | 33223 | 79578443 |
Influenza like illness | 65.82 | 10.13 | 265 | 132457 | 71442 | 79540224 |
Victim of child abuse | 65.73 | 10.13 | 32 | 132690 | 921 | 79610745 |
Hallucination | 65.70 | 10.13 | 300 | 132422 | 85445 | 79526221 |
Autonomic nervous system imbalance | 64.78 | 10.13 | 57 | 132665 | 4573 | 79607093 |
Device occlusion | 64.76 | 10.13 | 89 | 132633 | 11777 | 79599889 |
Device computer issue | 64.45 | 10.13 | 18 | 132704 | 94 | 79611572 |
Abdominal pain | 64.02 | 10.13 | 383 | 132339 | 389186 | 79222480 |
Magnetic resonance imaging abnormal | 63.85 | 10.13 | 50 | 132672 | 3409 | 79608257 |
Generalised tonic-clonic seizure | 63.72 | 10.13 | 189 | 132533 | 43721 | 79567945 |
Areflexia | 63.54 | 10.13 | 61 | 132661 | 5473 | 79606193 |
Movement disorder | 62.03 | 10.13 | 139 | 132583 | 27120 | 79584546 |
Muscle injury | 61.93 | 10.13 | 5 | 132717 | 48556 | 79563110 |
Micturition urgency | 61.87 | 10.13 | 90 | 132632 | 12551 | 79599115 |
Drug ineffective | 61.28 | 10.13 | 1353 | 131369 | 1079560 | 78532106 |
Pleural effusion | 60.96 | 10.13 | 92 | 132630 | 145170 | 79466496 |
Gastrointestinal haemorrhage | 60.61 | 10.13 | 95 | 132627 | 147624 | 79464042 |
JC polyomavirus test positive | 60.37 | 10.13 | 36 | 132686 | 1566 | 79610100 |
Hyporeflexia | 60.35 | 10.13 | 49 | 132673 | 3519 | 79608147 |
Sleep disorder due to general medical condition, insomnia type | 59.96 | 10.13 | 3 | 132719 | 43553 | 79568113 |
Paraparesis | 59.68 | 10.13 | 50 | 132672 | 3753 | 79607913 |
Cough | 59.53 | 10.13 | 362 | 132360 | 366427 | 79245239 |
Decreased appetite | 59.27 | 10.13 | 331 | 132391 | 342087 | 79269579 |
Delirium | 58.93 | 10.13 | 288 | 132434 | 84339 | 79527327 |
Swelling | 58.53 | 10.13 | 176 | 132546 | 216535 | 79395131 |
Myoclonus | 58.47 | 10.13 | 137 | 132585 | 27523 | 79584143 |
Blood creatinine increased | 57.84 | 10.13 | 106 | 132616 | 154951 | 79456715 |
Arthralgia | 57.72 | 10.13 | 641 | 132081 | 571162 | 79040504 |
Hypertonic bladder | 57.34 | 10.13 | 51 | 132671 | 4150 | 79607516 |
Drug delivery device placement | 57.09 | 10.13 | 19 | 132703 | 193 | 79611473 |
Disease progression | 57.09 | 10.13 | 140 | 132582 | 184222 | 79427444 |
Implant site haematoma | 56.93 | 10.13 | 18 | 132704 | 153 | 79611513 |
Hyperkalaemia | 56.68 | 10.13 | 64 | 132658 | 114334 | 79497332 |
Depression | 55.83 | 10.13 | 579 | 132143 | 216211 | 79395455 |
Escherichia urinary tract infection | 55.78 | 10.13 | 90 | 132632 | 13735 | 79597931 |
White blood cells urine positive | 55.19 | 10.13 | 59 | 132663 | 6016 | 79605650 |
Hepatic function abnormal | 54.06 | 10.13 | 27 | 132695 | 73080 | 79538586 |
Muscle twitching | 53.82 | 10.13 | 124 | 132598 | 24640 | 79587026 |
Cardiac failure congestive | 53.42 | 10.13 | 97 | 132625 | 142305 | 79469361 |
Monocyte percentage increased | 53.16 | 10.13 | 37 | 132685 | 2104 | 79609562 |
Insomnia | 52.74 | 10.13 | 632 | 132090 | 244538 | 79367128 |
Monoparesis | 52.71 | 10.13 | 45 | 132677 | 3466 | 79608200 |
Respiratory arrest | 52.27 | 10.13 | 212 | 132510 | 57338 | 79554328 |
Medical device site discomfort | 51.93 | 10.13 | 18 | 132704 | 209 | 79611457 |
Lymphocyte percentage decreased | 51.82 | 10.13 | 52 | 132670 | 4924 | 79606742 |
Medical device site inflammation | 51.38 | 10.13 | 10 | 132712 | 3 | 79611663 |
Optic neuritis | 51.35 | 10.13 | 71 | 132651 | 9449 | 79602217 |
Off label use | 51.21 | 10.13 | 1136 | 131586 | 906079 | 78705587 |
Toxic epidermal necrolysis | 50.69 | 10.13 | 7 | 132715 | 44574 | 79567092 |
Peroneal nerve palsy | 50.23 | 10.13 | 56 | 132666 | 5986 | 79605680 |
Ascites | 50.00 | 10.13 | 32 | 132690 | 75530 | 79536136 |
Epidural lipomatosis | 49.97 | 10.13 | 29 | 132693 | 1199 | 79610467 |
Multiple organ dysfunction syndrome | 49.64 | 10.13 | 77 | 132645 | 120169 | 79491497 |
Renal failure | 49.53 | 10.13 | 170 | 132552 | 200798 | 79410868 |
Urine leukocyte esterase positive | 48.69 | 10.13 | 46 | 132676 | 4045 | 79607621 |
Drug dependence | 48.62 | 10.13 | 164 | 132558 | 40605 | 79571061 |
Scoliosis | 48.50 | 10.13 | 61 | 132661 | 7403 | 79604263 |
Red blood cells urine positive | 48.30 | 10.13 | 50 | 132672 | 4913 | 79606753 |
Hepatic enzyme increased | 48.09 | 10.13 | 150 | 132572 | 182460 | 79429206 |
Haematochezia | 47.99 | 10.13 | 45 | 132677 | 87600 | 79524066 |
Device breakage | 47.94 | 10.13 | 73 | 132649 | 10602 | 79601064 |
Bone marrow failure | 47.66 | 10.13 | 13 | 132709 | 51094 | 79560572 |
Lower respiratory tract infection | 47.60 | 10.13 | 89 | 132633 | 129131 | 79482535 |
Dyskinesia | 47.26 | 10.13 | 173 | 132549 | 44600 | 79567066 |
Implant site scar | 47.24 | 10.13 | 17 | 132705 | 222 | 79611444 |
Therapeutic product effect decreased | 47.23 | 10.13 | 129 | 132593 | 163734 | 79447932 |
Arachnoiditis | 47.22 | 10.13 | 24 | 132698 | 759 | 79610907 |
Bacterial test positive | 47.02 | 10.13 | 60 | 132662 | 7389 | 79604277 |
Product use issue | 46.78 | 10.13 | 185 | 132537 | 209637 | 79402029 |
Paralysis | 46.77 | 10.13 | 81 | 132641 | 13096 | 79598570 |
Device programming error | 46.61 | 10.13 | 16 | 132706 | 180 | 79611486 |
Myelosuppression | 46.60 | 10.13 | 6 | 132716 | 40290 | 79571376 |
Osteonecrosis of jaw | 46.39 | 10.13 | 8 | 132714 | 43218 | 79568448 |
Poisoning deliberate | 46.24 | 10.13 | 99 | 132623 | 18729 | 79592937 |
Medical device site bruise | 46.02 | 10.13 | 9 | 132713 | 3 | 79611663 |
Pulmonary fibrosis | 45.54 | 10.13 | 9 | 132713 | 44103 | 79567563 |
Motor dysfunction | 45.20 | 10.13 | 85 | 132637 | 14648 | 79597018 |
Neutrophil percentage increased | 45.20 | 10.13 | 47 | 132675 | 4642 | 79607024 |
Dysarthria | 44.86 | 10.13 | 227 | 132495 | 67395 | 79544271 |
Gastrooesophageal reflux disease | 44.66 | 10.13 | 312 | 132410 | 103934 | 79507732 |
Wound | 44.60 | 10.13 | 78 | 132644 | 116101 | 79495565 |
Urinary retention | 44.01 | 10.13 | 199 | 132523 | 56431 | 79555235 |
Medical device site cellulitis | 44.01 | 10.13 | 9 | 132713 | 6 | 79611660 |
Drug interaction | 43.62 | 10.13 | 461 | 132261 | 414722 | 79196944 |
Pollakiuria | 43.52 | 10.13 | 149 | 132573 | 37168 | 79574498 |
Miosis | 43.45 | 10.13 | 87 | 132635 | 15702 | 79595964 |
Loss of consciousness | 43.44 | 10.13 | 449 | 132273 | 167494 | 79444172 |
Peripheral swelling | 43.24 | 10.13 | 267 | 132455 | 269350 | 79342316 |
Device leakage | 42.88 | 10.13 | 70 | 132652 | 10786 | 79600880 |
Dyspnoea exertional | 42.82 | 10.13 | 49 | 132673 | 87024 | 79524642 |
Hepatotoxicity | 42.68 | 10.13 | 16 | 132706 | 51336 | 79560330 |
Apnoea | 41.62 | 10.13 | 72 | 132650 | 11632 | 79600034 |
Gait inability | 41.37 | 10.13 | 201 | 132521 | 58716 | 79552950 |
Stomatitis | 41.20 | 10.13 | 117 | 132605 | 146640 | 79465026 |
Focal dyscognitive seizures | 40.87 | 10.13 | 39 | 132683 | 3473 | 79608193 |
Implant site abscess | 40.82 | 10.13 | 11 | 132711 | 49 | 79611617 |
Blister | 40.81 | 10.13 | 86 | 132636 | 119390 | 79492276 |
Rectal haemorrhage | 40.81 | 10.13 | 40 | 132682 | 76260 | 79535406 |
Pseudomeningocele | 40.66 | 10.13 | 8 | 132714 | 3 | 79611663 |
Immune reconstitution inflammatory syndrome | 40.18 | 10.13 | 78 | 132644 | 13763 | 79597903 |
Nitrite urine present | 40.01 | 10.13 | 25 | 132697 | 1184 | 79610482 |
Drug eruption | 39.45 | 10.13 | 12 | 132710 | 43923 | 79567743 |
Hypoglycaemia | 39.18 | 10.13 | 68 | 132654 | 101526 | 79510140 |
Epistaxis | 39.17 | 10.13 | 79 | 132643 | 111436 | 79500230 |
Urinary sediment present | 39.10 | 10.13 | 33 | 132689 | 2502 | 79609164 |
Dysstasia | 38.90 | 10.13 | 118 | 132604 | 27628 | 79584038 |
Hypersensitivity | 38.85 | 10.13 | 266 | 132456 | 261973 | 79349693 |
Psoriatic arthropathy | 38.24 | 10.13 | 44 | 132678 | 77955 | 79533711 |
Wheezing | 38.18 | 10.13 | 86 | 132636 | 116578 | 79495088 |
Sleep apnoea syndrome | 37.71 | 10.13 | 140 | 132582 | 36338 | 79575328 |
Irritability | 37.71 | 10.13 | 152 | 132570 | 40992 | 79570674 |
Cytomegalovirus infection | 37.66 | 10.13 | 12 | 132710 | 42632 | 79569034 |
Respiratory rate decreased | 37.55 | 10.13 | 45 | 132677 | 5198 | 79606468 |
Muscle contracture | 37.47 | 10.13 | 31 | 132691 | 2286 | 79609380 |
Erythema | 37.44 | 10.13 | 218 | 132504 | 223072 | 79388594 |
Liver injury | 37.42 | 10.13 | 24 | 132698 | 56590 | 79555076 |
Oedema peripheral | 37.32 | 10.13 | 256 | 132466 | 252032 | 79359634 |
Paraesthesia | 37.23 | 10.13 | 453 | 132269 | 175870 | 79435796 |
Device extrusion | 37.22 | 10.13 | 9 | 132713 | 23 | 79611643 |
Drug resistance | 37.06 | 10.13 | 12 | 132710 | 42201 | 79569465 |
Accidental overdose | 36.89 | 10.13 | 147 | 132575 | 39434 | 79572232 |
Concussion | 35.82 | 10.13 | 60 | 132662 | 9443 | 79602223 |
Altered state of consciousness | 35.57 | 10.13 | 156 | 132566 | 43666 | 79568000 |
C-reactive protein abnormal | 35.55 | 10.13 | 18 | 132704 | 48349 | 79563317 |
Stiff person syndrome | 35.51 | 10.13 | 15 | 132707 | 307 | 79611359 |
Hyperhidrosis | 35.44 | 10.13 | 397 | 132325 | 151095 | 79460571 |
Bradycardia | 35.32 | 10.13 | 363 | 132359 | 135194 | 79476472 |
Hypomagnesaemia | 35.17 | 10.13 | 17 | 132705 | 46894 | 79564772 |
Tubulointerstitial nephritis | 35.14 | 10.13 | 10 | 132712 | 38225 | 79573441 |
Treatment failure | 35.09 | 10.13 | 155 | 132567 | 170331 | 79441335 |
Speech disorder | 34.88 | 10.13 | 181 | 132541 | 54264 | 79557402 |
Alcohol withdrawal syndrome | 34.83 | 10.13 | 28 | 132694 | 1983 | 79609683 |
Alopecia | 34.59 | 10.13 | 234 | 132488 | 231121 | 79380545 |
Delirium tremens | 34.27 | 10.13 | 19 | 132703 | 719 | 79610947 |
Burning sensation | 34.22 | 10.13 | 190 | 132532 | 58442 | 79553224 |
Medical device site haematoma | 34.18 | 10.13 | 9 | 132713 | 36 | 79611630 |
Implant site cellulitis | 34.14 | 10.13 | 11 | 132711 | 100 | 79611566 |
B-lymphocyte count decreased | 34.09 | 10.13 | 24 | 132698 | 1390 | 79610276 |
Irritable bowel syndrome | 34.02 | 10.13 | 32 | 132690 | 62209 | 79549457 |
Medical device site extravasation | 33.48 | 10.13 | 7 | 132715 | 6 | 79611660 |
Medical device site reaction | 33.48 | 10.13 | 7 | 132715 | 6 | 79611660 |
Soft tissue injury | 33.43 | 10.13 | 26 | 132696 | 1755 | 79609911 |
Intentional product use issue | 33.34 | 10.13 | 135 | 132587 | 151977 | 79459689 |
Pneumocystis jirovecii pneumonia | 32.80 | 10.13 | 7 | 132715 | 32501 | 79579165 |
Agranulocytosis | 32.74 | 10.13 | 17 | 132705 | 45013 | 79566653 |
Neoplasm progression | 32.69 | 10.13 | 23 | 132699 | 51659 | 79560007 |
Neutrophil count decreased | 32.62 | 10.13 | 67 | 132655 | 93892 | 79517774 |
Melaena | 32.47 | 10.13 | 32 | 132690 | 60858 | 79550808 |
Alcohol poisoning | 32.29 | 10.13 | 40 | 132682 | 4781 | 79606885 |
Liver disorder | 32.21 | 10.13 | 44 | 132678 | 72373 | 79539293 |
Euphoric mood | 32.13 | 10.13 | 51 | 132671 | 7675 | 79603991 |
Dysaesthesia | 32.12 | 10.13 | 44 | 132678 | 5804 | 79605862 |
Hypercalcaemia | 31.89 | 10.13 | 12 | 132710 | 38418 | 79573248 |
Palmar-plantar erythrodysaesthesia syndrome | 31.71 | 10.13 | 8 | 132714 | 33126 | 79578540 |
Seroma | 31.55 | 10.13 | 28 | 132694 | 2272 | 79609394 |
Incorrect drug administration rate | 31.23 | 10.13 | 36 | 132686 | 3990 | 79607676 |
Loss of control of legs | 31.18 | 10.13 | 26 | 132696 | 1939 | 79609727 |
Pulmonary renal syndrome | 31.16 | 10.13 | 17 | 132705 | 623 | 79611043 |
Proteinuria | 30.81 | 10.13 | 8 | 132714 | 32494 | 79579172 |
Lymphopenia | 30.52 | 10.13 | 116 | 132606 | 30441 | 79581225 |
Nasopharyngitis | 30.38 | 10.13 | 273 | 132449 | 253608 | 79358058 |
Implant site dehiscence | 30.28 | 10.13 | 10 | 132712 | 99 | 79611567 |
Haemoglobin decreased | 30.13 | 10.13 | 231 | 132491 | 221888 | 79389778 |
Gastrointestinal disorder | 29.67 | 10.13 | 104 | 132618 | 122101 | 79489565 |
Weight increased | 29.50 | 10.13 | 307 | 132415 | 277079 | 79334587 |
Medical device discomfort | 29.48 | 10.13 | 24 | 132698 | 1730 | 79609936 |
Disorientation | 29.34 | 10.13 | 192 | 132530 | 62584 | 79549082 |
Erectile dysfunction | 29.23 | 10.13 | 71 | 132651 | 14593 | 79597073 |
Haemoptysis | 29.21 | 10.13 | 30 | 132692 | 55969 | 79555697 |
Pneumonitis | 29.12 | 10.13 | 35 | 132687 | 60825 | 79550841 |
Meningitis | 29.04 | 10.13 | 55 | 132667 | 9527 | 79602139 |
Dysphagia | 28.99 | 10.13 | 321 | 132401 | 121815 | 79489851 |
Anxiety | 28.81 | 10.13 | 577 | 132145 | 247935 | 79363731 |
Culture urine positive | 28.43 | 10.13 | 36 | 132686 | 4399 | 79607267 |
Band neutrophil percentage increased | 28.38 | 10.13 | 14 | 132708 | 415 | 79611251 |
Medical device site ulcer | 28.25 | 10.13 | 6 | 132716 | 6 | 79611660 |
Anal incontinence | 28.08 | 10.13 | 80 | 132642 | 18088 | 79593578 |
Sensory disturbance | 27.95 | 10.13 | 71 | 132651 | 15006 | 79596660 |
Expanded disability status scale score increased | 27.94 | 10.13 | 16 | 132706 | 645 | 79611021 |
Autonomic dysreflexia | 27.80 | 10.13 | 14 | 132708 | 434 | 79611232 |
Hypothermia | 27.56 | 10.13 | 92 | 132630 | 22654 | 79589012 |
Macrophages increased | 27.41 | 10.13 | 12 | 132710 | 269 | 79611397 |
Temperature intolerance | 27.33 | 10.13 | 54 | 132668 | 9651 | 79602015 |
Incorrect route of product administration | 27.33 | 10.13 | 123 | 132599 | 34806 | 79576860 |
Band neutrophil count increased | 27.30 | 10.13 | 16 | 132706 | 674 | 79610992 |
International normalised ratio increased | 27.27 | 10.13 | 63 | 132659 | 84658 | 79527008 |
Migraine | 27.09 | 10.13 | 243 | 132479 | 87250 | 79524416 |
Cholestasis | 27.08 | 10.13 | 28 | 132694 | 52081 | 79559585 |
Suicide attempt | 27.06 | 10.13 | 233 | 132489 | 82699 | 79528967 |
Infusion site fibrosis | 27 | 10.13 | 5 | 132717 | 0 | 79611666 |
Medical device site warmth | 27 | 10.13 | 5 | 132717 | 0 | 79611666 |
Neutropenic sepsis | 26.95 | 10.13 | 6 | 132716 | 27058 | 79584608 |
Incoherent | 26.93 | 10.13 | 47 | 132675 | 7645 | 79604021 |
Bronchiectasis | 26.71 | 10.13 | 3 | 132719 | 22383 | 79589283 |
Angina pectoris | 26.66 | 10.13 | 28 | 132694 | 51704 | 79559962 |
Discomfort | 26.58 | 10.13 | 113 | 132609 | 125504 | 79486162 |
Coma scale abnormal | 26.54 | 10.13 | 50 | 132672 | 8628 | 79603038 |
Hyperreflexia | 26.50 | 10.13 | 49 | 132673 | 8336 | 79603330 |
Road traffic accident | 26.49 | 10.13 | 143 | 132579 | 43521 | 79568145 |
Hypoventilation | 26.42 | 10.13 | 45 | 132677 | 7179 | 79604487 |
Knee arthroplasty | 26.38 | 10.13 | 20 | 132702 | 43228 | 79568438 |
Eosinophilia | 26.36 | 10.13 | 22 | 132700 | 45323 | 79566343 |
Implant site reaction | 26.28 | 10.13 | 10 | 132712 | 154 | 79611512 |
Vitamin D deficiency | 26.22 | 10.13 | 67 | 132655 | 14212 | 79597454 |
Feeling abnormal | 26.17 | 10.13 | 391 | 132331 | 158808 | 79452858 |
Rash maculo-papular | 26.04 | 10.13 | 33 | 132689 | 56045 | 79555621 |
Incision site oedema | 25.83 | 10.13 | 6 | 132716 | 12 | 79611654 |
Post-traumatic neck syndrome | 25.80 | 10.13 | 24 | 132698 | 2070 | 79609596 |
Hypervolaemia | 25.71 | 10.13 | 20 | 132702 | 42670 | 79568996 |
Bladder dysfunction | 25.63 | 10.13 | 19 | 132703 | 1193 | 79610473 |
Sternal fracture | 25.54 | 10.13 | 26 | 132696 | 2504 | 79609162 |
Child abuse | 25.44 | 10.13 | 13 | 132709 | 416 | 79611250 |
Hallucination, visual | 25.42 | 10.13 | 115 | 132607 | 32614 | 79579052 |
Amnesia | 25.42 | 10.13 | 186 | 132536 | 62871 | 79548795 |
Purulent discharge | 25.30 | 10.13 | 40 | 132682 | 5999 | 79605667 |
Hallucinations, mixed | 25.26 | 10.13 | 43 | 132679 | 6856 | 79604810 |
Device expulsion | 25.22 | 10.13 | 6 | 132716 | 25855 | 79585811 |
Adrenal insufficiency | 25.18 | 10.13 | 8 | 132714 | 28479 | 79583187 |
Hepatic cytolysis | 25.14 | 10.13 | 7 | 132715 | 27144 | 79584522 |
Metastases to liver | 24.94 | 10.13 | 8 | 132714 | 28306 | 79583360 |
Blood bilirubin increased | 24.93 | 10.13 | 45 | 132677 | 66187 | 79545479 |
Urinary tract infection pseudomonal | 24.88 | 10.13 | 22 | 132700 | 1776 | 79609890 |
Urobilinogen urine increased | 24.84 | 10.13 | 15 | 132707 | 668 | 79610998 |
Hypokinesia | 24.81 | 10.13 | 79 | 132643 | 18981 | 79592685 |
Libido increased | 24.78 | 10.13 | 23 | 132699 | 1978 | 79609688 |
Flushing | 24.74 | 10.13 | 240 | 132482 | 88028 | 79523638 |
Pain | 24.74 | 10.13 | 1419 | 131303 | 702383 | 78909283 |
Medical device site scar | 24.66 | 10.13 | 5 | 132717 | 3 | 79611663 |
Postoperative delirium | 24.47 | 10.13 | 12 | 132710 | 351 | 79611315 |
Tumour lysis syndrome | 24.47 | 10.13 | 5 | 132717 | 23934 | 79587732 |
Bronchopulmonary aspergillosis | 24.20 | 10.13 | 4 | 132718 | 22290 | 79589376 |
Drug hypersensitivity | 24.15 | 10.13 | 351 | 132371 | 298565 | 79313101 |
Disturbance in attention | 24.12 | 10.13 | 156 | 132566 | 50645 | 79561021 |
Colitis ulcerative | 23.97 | 10.13 | 14 | 132708 | 34728 | 79576938 |
Drug reaction with eosinophilia and systemic symptoms | 23.87 | 10.13 | 44 | 132678 | 64200 | 79547466 |
Intervertebral disc protrusion | 23.87 | 10.13 | 90 | 132632 | 23531 | 79588135 |
Hostility | 23.80 | 10.13 | 24 | 132698 | 2286 | 79609380 |
Patient-device incompatibility | 23.69 | 10.13 | 9 | 132713 | 138 | 79611528 |
Ankle fracture | 23.63 | 10.13 | 72 | 132650 | 16897 | 79594769 |
Performance status decreased | 23.58 | 10.13 | 39 | 132683 | 6074 | 79605592 |
Epilepsy | 23.57 | 10.13 | 132 | 132590 | 40728 | 79570938 |
CSF culture positive | 23.45 | 10.13 | 7 | 132715 | 48 | 79611618 |
Poor quality sleep | 23.31 | 10.13 | 87 | 132635 | 22635 | 79589031 |
Bacterial test | 23.27 | 10.13 | 18 | 132704 | 1205 | 79610461 |
Rash pruritic | 23.27 | 10.13 | 53 | 132669 | 71576 | 79540090 |
Product use in unapproved indication | 23.12 | 10.13 | 286 | 132436 | 250073 | 79361593 |
Nystagmus | 23.09 | 10.13 | 51 | 132671 | 9853 | 79601813 |
Sinusitis | 23.04 | 10.13 | 211 | 132511 | 195290 | 79416376 |
Staphylococcal infection | 22.95 | 10.13 | 171 | 132551 | 58124 | 79553542 |
Pupil fixed | 22.94 | 10.13 | 29 | 132693 | 3537 | 79608129 |
Incision site erythema | 22.93 | 10.13 | 13 | 132709 | 514 | 79611152 |
CD4 lymphocytes decreased | 22.91 | 10.13 | 25 | 132697 | 2609 | 79609057 |
Cytokine release syndrome | 22.80 | 10.13 | 16 | 132706 | 35982 | 79575684 |
Inadequate analgesia | 22.71 | 10.13 | 33 | 132689 | 4596 | 79607070 |
Oedema | 22.66 | 10.13 | 112 | 132610 | 119468 | 79492198 |
Abnormal behaviour | 22.58 | 10.13 | 120 | 132602 | 36301 | 79575365 |
Blood cholesterol increased | 22.58 | 10.13 | 68 | 132654 | 83652 | 79528014 |
Hypocalcaemia | 22.54 | 10.13 | 30 | 132692 | 49894 | 79561772 |
Nephrolithiasis | 22.52 | 10.13 | 159 | 132563 | 53132 | 79558534 |
Decreased vibratory sense | 22.48 | 10.13 | 14 | 132708 | 659 | 79611007 |
Primary progressive multiple sclerosis | 22.19 | 10.13 | 8 | 132714 | 105 | 79611561 |
Basal ganglion degeneration | 22.09 | 10.13 | 12 | 132710 | 436 | 79611230 |
Implant site oedema | 22.04 | 10.13 | 6 | 132716 | 28 | 79611638 |
Urinary tract infection bacterial | 22.02 | 10.13 | 39 | 132683 | 6417 | 79605249 |
Vitamin B6 deficiency | 22.02 | 10.13 | 11 | 132711 | 335 | 79611331 |
Dehydration | 21.99 | 10.13 | 286 | 132436 | 247901 | 79363765 |
Paraplegia | 21.91 | 10.13 | 34 | 132688 | 5019 | 79606647 |
Infusion site granuloma | 21.87 | 10.13 | 5 | 132717 | 9 | 79611657 |
Right ventricular failure | 21.86 | 10.13 | 6 | 132716 | 23491 | 79588175 |
Therapeutic response unexpected | 21.84 | 10.13 | 78 | 132644 | 19868 | 79591798 |
Haemorrhage | 21.81 | 10.13 | 78 | 132644 | 91040 | 79520626 |
Hepatitis | 21.76 | 10.13 | 37 | 132685 | 55690 | 79555976 |
Bladder spasm | 21.72 | 10.13 | 23 | 132699 | 2320 | 79609346 |
Frequent bowel movements | 21.70 | 10.13 | 11 | 132711 | 29528 | 79582138 |
Fluctuance | 21.60 | 10.13 | 4 | 132718 | 0 | 79611666 |
Medical device site vesicles | 21.60 | 10.13 | 4 | 132718 | 0 | 79611666 |
Implant site ulcer | 21.60 | 10.13 | 4 | 132718 | 0 | 79611666 |
Pulmonary hypertension | 21.60 | 10.13 | 29 | 132693 | 48051 | 79563615 |
Productive cough | 21.56 | 10.13 | 75 | 132647 | 88256 | 79523410 |
Haemophagocytic lymphohistiocytosis | 21.43 | 10.13 | 5 | 132717 | 21832 | 79589834 |
Poisoning | 21.30 | 10.13 | 91 | 132631 | 25181 | 79586485 |
Implant site vesicles | 21.22 | 10.13 | 6 | 132716 | 33 | 79611633 |
Nausea | 21.16 | 10.13 | 1342 | 131380 | 955854 | 78655812 |
Posturing | 21.14 | 10.13 | 16 | 132706 | 1037 | 79610629 |
Asthma | 21.01 | 10.13 | 135 | 132587 | 134960 | 79476706 |
Chronic kidney disease | 20.65 | 10.13 | 50 | 132672 | 66104 | 79545562 |
Brain stem syndrome | 20.65 | 10.13 | 15 | 132707 | 913 | 79610753 |
Stevens-Johnson syndrome | 20.41 | 10.13 | 21 | 132701 | 39145 | 79572521 |
Neurogenic bowel | 20.30 | 10.13 | 9 | 132713 | 208 | 79611458 |
Spinal cord injury | 20.27 | 10.13 | 17 | 132705 | 1278 | 79610388 |
Muscle contractions involuntary | 20.19 | 10.13 | 28 | 132694 | 3737 | 79607929 |
Toxic skin eruption | 20.18 | 10.13 | 6 | 132716 | 22287 | 79589379 |
Tethered cord syndrome | 20.09 | 10.13 | 5 | 132717 | 15 | 79611651 |
Brain injury | 20.08 | 10.13 | 53 | 132669 | 11464 | 79600202 |
Bladder disorder | 20.03 | 10.13 | 46 | 132676 | 9119 | 79602547 |
Nocturia | 19.95 | 10.13 | 59 | 132663 | 13622 | 79598044 |
Leukopenia | 19.92 | 10.13 | 113 | 132609 | 116400 | 79495266 |
Aplastic anaemia | 19.92 | 10.13 | 3 | 132719 | 17902 | 79593764 |
Thyroid disorder | 19.85 | 10.13 | 60 | 132662 | 14019 | 79597647 |
Intestinal pseudo-obstruction | 19.69 | 10.13 | 23 | 132699 | 2586 | 79609080 |
Tissue infiltration | 19.68 | 10.13 | 13 | 132709 | 678 | 79610988 |
Urticaria | 19.67 | 10.13 | 205 | 132517 | 184996 | 79426670 |
T-lymphocyte count decreased | 19.46 | 10.13 | 12 | 132710 | 555 | 79611111 |
Central nervous system infection | 19.36 | 10.13 | 17 | 132705 | 1360 | 79610306 |
Cytopenia | 19.35 | 10.13 | 5 | 132717 | 20378 | 79591288 |
Pancreatitis acute | 19.31 | 10.13 | 33 | 132689 | 49571 | 79562095 |
Coronary artery disease | 19.26 | 10.13 | 51 | 132671 | 65423 | 79546243 |
COVID-19 | 19.24 | 10.13 | 369 | 132353 | 157305 | 79454361 |
Persistent depressive disorder | 19.23 | 10.13 | 16 | 132706 | 1189 | 79610477 |
Presyncope | 19.23 | 10.13 | 24 | 132698 | 41030 | 79570636 |
Anaphylactic shock | 19.10 | 10.13 | 19 | 132703 | 35977 | 79575689 |
Lactic acidosis | 19.08 | 10.13 | 57 | 132665 | 70302 | 79541364 |
Monoplegia | 19.04 | 10.13 | 28 | 132694 | 3943 | 79607723 |
C-reactive protein increased | 19.02 | 10.13 | 131 | 132591 | 128896 | 79482770 |
Intervertebral disc disorder | 18.91 | 10.13 | 31 | 132691 | 4794 | 79606872 |
Muscle atrophy | 18.88 | 10.13 | 51 | 132671 | 11181 | 79600485 |
Metabolic acidosis | 18.87 | 10.13 | 72 | 132650 | 82457 | 79529209 |
Type 2 diabetes mellitus | 18.77 | 10.13 | 42 | 132680 | 57080 | 79554586 |
Post procedural complication | 18.71 | 10.13 | 84 | 132638 | 23745 | 79587921 |
Incision site complication | 18.62 | 10.13 | 13 | 132709 | 743 | 79610923 |
Hypersomnia | 18.59 | 10.13 | 82 | 132640 | 23004 | 79588662 |
Musculoskeletal stiffness | 18.52 | 10.13 | 401 | 132321 | 174607 | 79437059 |
Hyporesponsive to stimuli | 18.48 | 10.13 | 20 | 132702 | 2068 | 79609598 |
CD8 lymphocytes decreased | 18.46 | 10.13 | 9 | 132713 | 260 | 79611406 |
Faeces discoloured | 18.37 | 10.13 | 13 | 132709 | 29114 | 79582552 |
Abdominal pain upper | 18.35 | 10.13 | 262 | 132460 | 223557 | 79388109 |
Lipoma | 18.31 | 10.13 | 24 | 132698 | 3035 | 79608631 |
Neuropathy peripheral | 18.20 | 10.13 | 149 | 132573 | 141156 | 79470510 |
Metastases to bone | 18.09 | 10.13 | 9 | 132713 | 24418 | 79587248 |
Colitis | 18.05 | 10.13 | 62 | 132660 | 73245 | 79538421 |
Crystal urine present | 17.92 | 10.13 | 20 | 132702 | 2140 | 79609526 |
Diplopia | 17.92 | 10.13 | 106 | 132616 | 33360 | 79578306 |
Wound infection staphylococcal | 17.79 | 10.13 | 24 | 132698 | 3120 | 79608546 |
Polyneuropathy | 17.73 | 10.13 | 9 | 132713 | 24142 | 79587524 |
Respiratory failure | 17.72 | 10.13 | 410 | 132312 | 180501 | 79431165 |
Jaundice | 17.71 | 10.13 | 39 | 132683 | 53310 | 79558356 |
Anaesthesia | 17.70 | 10.13 | 11 | 132711 | 516 | 79611150 |
Blood pressure diastolic abnormal | 17.69 | 10.13 | 5 | 132717 | 19197 | 79592469 |
Mydriasis | 17.64 | 10.13 | 67 | 132655 | 17576 | 79594090 |
Cognitive disorder | 17.61 | 10.13 | 186 | 132536 | 69740 | 79541926 |
Coordination abnormal | 17.52 | 10.13 | 66 | 132656 | 17246 | 79594420 |
Intervertebral disc degeneration | 17.51 | 10.13 | 62 | 132660 | 15723 | 79595943 |
Incision site swelling | 17.41 | 10.13 | 9 | 132713 | 295 | 79611371 |
Brief psychotic disorder with marked stressors | 17.27 | 10.13 | 9 | 132713 | 300 | 79611366 |
Impaired healing | 17.24 | 10.13 | 81 | 132641 | 87574 | 79524092 |
Cerebral infarction | 17.22 | 10.13 | 31 | 132691 | 45645 | 79566021 |
Hyperaesthesia | 17.15 | 10.13 | 52 | 132670 | 12170 | 79599496 |
Pulmonary oedema | 17.10 | 10.13 | 82 | 132640 | 88172 | 79523494 |
Pre-existing disease | 17.04 | 10.13 | 8 | 132714 | 212 | 79611454 |
Vision blurred | 16.97 | 10.13 | 259 | 132463 | 105639 | 79506027 |
Lipoedema | 16.97 | 10.13 | 8 | 132714 | 214 | 79611452 |
Back disorder | 16.95 | 10.13 | 50 | 132672 | 11528 | 79600138 |
Thyroxine decreased | 16.94 | 10.13 | 13 | 132709 | 860 | 79610806 |
Narcissistic personality disorder | 16.90 | 10.13 | 4 | 132718 | 9 | 79611657 |
Upper airway obstruction | 16.89 | 10.13 | 16 | 132706 | 1412 | 79610254 |
Hemiparesis | 16.89 | 10.13 | 105 | 132617 | 33628 | 79578038 |
Invasive ductal breast carcinoma | 16.85 | 10.13 | 33 | 132689 | 5859 | 79605807 |
Acute generalised exanthematous pustulosis | 16.83 | 10.13 | 4 | 132718 | 17250 | 79594416 |
Alanine aminotransferase increased | 16.83 | 10.13 | 181 | 132541 | 162389 | 79449277 |
Back pain | 16.83 | 10.13 | 642 | 132080 | 303538 | 79308128 |
Conversion disorder | 16.78 | 10.13 | 18 | 132704 | 1843 | 79609823 |
Acute myeloid leukaemia | 16.73 | 10.13 | 16 | 132706 | 30869 | 79580797 |
Cystitis | 16.60 | 10.13 | 147 | 132575 | 52585 | 79559081 |
Quadriplegia | 16.55 | 10.13 | 24 | 132698 | 3336 | 79608330 |
Juvenile idiopathic arthritis | 16.54 | 10.13 | 29 | 132693 | 4734 | 79606932 |
Uterine enlargement | 16.49 | 10.13 | 13 | 132709 | 895 | 79610771 |
Infected skin ulcer | 16.33 | 10.13 | 24 | 132698 | 3377 | 79608289 |
Angioedema | 16.33 | 10.13 | 68 | 132654 | 75967 | 79535699 |
Fibula fracture | 16.32 | 10.13 | 25 | 132697 | 3649 | 79608017 |
Glossopharyngeal nerve disorder | 16.30 | 10.13 | 5 | 132717 | 38 | 79611628 |
Obstructive airways disorder | 16.24 | 10.13 | 17 | 132705 | 31442 | 79580224 |
Medical device site rash | 16.20 | 10.13 | 3 | 132719 | 0 | 79611666 |
Medical device site oedema | 16.20 | 10.13 | 3 | 132719 | 0 | 79611666 |
Medical device site mass | 16.20 | 10.13 | 3 | 132719 | 0 | 79611666 |
Urine oxalate increased | 16.10 | 10.13 | 8 | 132714 | 241 | 79611425 |
Mean platelet volume increased | 16.09 | 10.13 | 14 | 132708 | 1106 | 79610560 |
Psychotic disorder | 16.04 | 10.13 | 121 | 132601 | 41281 | 79570385 |
Protein total decreased | 16.01 | 10.13 | 42 | 132680 | 9050 | 79602616 |
Myocardial infarction | 16.00 | 10.13 | 213 | 132509 | 183916 | 79427750 |
Myelocyte percentage increased | 15.95 | 10.13 | 8 | 132714 | 246 | 79611420 |
Excessive granulation tissue | 15.95 | 10.13 | 13 | 132709 | 939 | 79610727 |
Intervertebral disc operation | 15.90 | 10.13 | 13 | 132709 | 943 | 79610723 |
Quadriparesis | 15.80 | 10.13 | 24 | 132698 | 3477 | 79608189 |
Haematuria | 15.77 | 10.13 | 60 | 132662 | 68776 | 79542890 |
Blood pressure fluctuation | 15.72 | 10.13 | 58 | 132664 | 67087 | 79544579 |
Gout | 15.67 | 10.13 | 11 | 132711 | 24738 | 79586928 |
Graft versus host disease | 15.65 | 10.13 | 3 | 132719 | 15023 | 79596643 |
Metastases to central nervous system | 15.58 | 10.13 | 4 | 132718 | 16371 | 79595295 |
Pancreatitis | 15.56 | 10.13 | 60 | 132662 | 68515 | 79543151 |
Urinary tract infection enterococcal | 15.46 | 10.13 | 23 | 132699 | 3272 | 79608394 |
Shock haemorrhagic | 15.45 | 10.13 | 7 | 132715 | 20053 | 79591613 |
Premature delivery | 15.44 | 10.13 | 10 | 132712 | 23457 | 79588209 |
Spinal operation | 15.43 | 10.13 | 38 | 132684 | 7879 | 79603787 |
Chest pain | 15.40 | 10.13 | 355 | 132367 | 281949 | 79329717 |
Vertebral foraminal stenosis | 15.37 | 10.13 | 14 | 132708 | 1175 | 79610491 |
Ventricular tachycardia | 15.33 | 10.13 | 29 | 132693 | 41906 | 79569760 |
Tibia fracture | 15.30 | 10.13 | 30 | 132692 | 5331 | 79606335 |
Skin reaction | 15.23 | 10.13 | 60 | 132662 | 16008 | 79595658 |
Blood sodium increased | 15.12 | 10.13 | 28 | 132694 | 4770 | 79606896 |
Drug screen positive | 15.02 | 10.13 | 32 | 132690 | 6031 | 79605635 |
Injury | 15.02 | 10.13 | 72 | 132650 | 77424 | 79534242 |
Stitch abscess | 14.92 | 10.13 | 5 | 132717 | 52 | 79611614 |
Weight decreased | 14.84 | 10.13 | 464 | 132258 | 354734 | 79256932 |
Staphylococcus test positive | 14.69 | 10.13 | 33 | 132689 | 6448 | 79605218 |
Second primary malignancy | 14.66 | 10.13 | 3 | 132719 | 14347 | 79597319 |
Peripheral nerve operation | 14.64 | 10.13 | 4 | 132718 | 19 | 79611647 |
Ulcer | 14.59 | 10.13 | 17 | 132705 | 29955 | 79581711 |
Injection site necrosis | 14.58 | 10.13 | 15 | 132707 | 1463 | 79610203 |
Blood ketone body increased | 14.56 | 10.13 | 11 | 132711 | 711 | 79610955 |
Urine abnormality | 14.51 | 10.13 | 38 | 132684 | 8181 | 79603485 |
Pregnancy | 14.44 | 10.13 | 14 | 132708 | 26837 | 79584829 |
Neurosis | 14.37 | 10.13 | 9 | 132713 | 428 | 79611238 |
Arrhythmia | 14.30 | 10.13 | 53 | 132669 | 61219 | 79550447 |
Eosinophil percentage increased | 14.25 | 10.13 | 15 | 132707 | 1503 | 79610163 |
CSF shunt operation | 14.13 | 10.13 | 3 | 132719 | 3 | 79611663 |
Incision site vesicles | 14.13 | 10.13 | 3 | 132719 | 3 | 79611663 |
Retinal depigmentation | 14.09 | 10.13 | 8 | 132714 | 317 | 79611349 |
Myocardial ischaemia | 14.09 | 10.13 | 13 | 132709 | 25506 | 79586160 |
Streptococcus test positive | 14.08 | 10.13 | 18 | 132704 | 2220 | 79609446 |
Creatinine renal clearance decreased | 14.07 | 10.13 | 7 | 132715 | 18995 | 79592671 |
Post laminectomy syndrome | 14.07 | 10.13 | 8 | 132714 | 318 | 79611348 |
Unevaluable event | 14.07 | 10.13 | 148 | 132574 | 55437 | 79556229 |
Posture abnormal | 14.03 | 10.13 | 24 | 132698 | 3842 | 79607824 |
Tonic clonic movements | 13.92 | 10.13 | 18 | 132704 | 2246 | 79609420 |
Lung disorder | 13.84 | 10.13 | 78 | 132644 | 80479 | 79531187 |
General symptom | 13.82 | 10.13 | 19 | 132703 | 2515 | 79609151 |
Frontotemporal dementia | 13.82 | 10.13 | 10 | 132712 | 605 | 79611061 |
Therapeutic product effect incomplete | 13.76 | 10.13 | 160 | 132562 | 141485 | 79470181 |
Medical device site irritation | 13.72 | 10.13 | 4 | 132718 | 25 | 79611641 |
Implant site mass | 13.71 | 10.13 | 5 | 132717 | 68 | 79611598 |
Mouth ulceration | 13.65 | 10.13 | 27 | 132695 | 38367 | 79573299 |
Implant site rash | 13.56 | 10.13 | 6 | 132716 | 138 | 79611528 |
Orthostatic hypotension | 13.49 | 10.13 | 48 | 132674 | 56116 | 79555550 |
Neck pain | 13.48 | 10.13 | 188 | 132534 | 75229 | 79536437 |
Asthenia | 13.47 | 10.13 | 1007 | 131715 | 510682 | 79100984 |
Major depression | 13.35 | 10.13 | 39 | 132683 | 8941 | 79602725 |
Cervical spinal stenosis | 13.34 | 10.13 | 18 | 132704 | 2341 | 79609325 |
Injection site abscess | 13.29 | 10.13 | 15 | 132707 | 1625 | 79610041 |
Urinary sediment abnormal | 13.29 | 10.13 | 6 | 132716 | 145 | 79611521 |
Purpura | 13.29 | 10.13 | 8 | 132714 | 19519 | 79592147 |
Hypervigilance | 13.28 | 10.13 | 9 | 132713 | 490 | 79611176 |
Death | 13.21 | 10.13 | 790 | 131932 | 565724 | 79045942 |
Device material issue | 13.18 | 10.13 | 7 | 132715 | 243 | 79611423 |
Upper gastrointestinal haemorrhage | 13.13 | 10.13 | 31 | 132691 | 41349 | 79570317 |
Nervous system disorder | 13.07 | 10.13 | 83 | 132639 | 26773 | 79584893 |
Spinal cord injury cauda equina | 13.03 | 10.13 | 6 | 132716 | 152 | 79611514 |
Prescribed underdose | 13.02 | 10.13 | 89 | 132633 | 29425 | 79582241 |
Hyponatraemia | 12.94 | 10.13 | 213 | 132509 | 177635 | 79434031 |
Psychogenic seizure | 12.90 | 10.13 | 16 | 132706 | 1915 | 79609751 |
Myelodysplastic syndrome | 12.89 | 10.13 | 19 | 132703 | 30282 | 79581384 |
Cerebral vasoconstriction | 12.87 | 10.13 | 14 | 132708 | 1456 | 79610210 |
Pericardial effusion | 12.87 | 10.13 | 37 | 132685 | 46200 | 79565466 |
Rotator cuff syndrome | 12.85 | 10.13 | 52 | 132670 | 14043 | 79597623 |
Adverse event | 12.83 | 10.13 | 54 | 132668 | 60160 | 79551506 |
Hip arthroplasty | 12.83 | 10.13 | 25 | 132697 | 35731 | 79575935 |
Cardiogenic shock | 12.83 | 10.13 | 32 | 132690 | 41882 | 79569784 |
Postoperative wound infection | 12.78 | 10.13 | 49 | 132673 | 12912 | 79598754 |
Blood ethanol increased | 12.75 | 10.13 | 10 | 132712 | 683 | 79610983 |
Blood folate increased | 12.70 | 10.13 | 9 | 132713 | 527 | 79611139 |
Klebsiella test positive | 12.69 | 10.13 | 15 | 132707 | 1708 | 79609958 |
Specific gravity urine decreased | 12.67 | 10.13 | 11 | 132711 | 867 | 79610799 |
Hypoxic-ischaemic encephalopathy | 12.64 | 10.13 | 35 | 132687 | 7785 | 79603881 |
Glycosylated haemoglobin decreased | 12.64 | 10.13 | 10 | 132712 | 692 | 79610974 |
Immature granulocyte percentage increased | 12.64 | 10.13 | 5 | 132717 | 86 | 79611580 |
Intraductal proliferative breast lesion | 12.58 | 10.13 | 18 | 132704 | 2473 | 79609193 |
Colitis microscopic | 12.56 | 10.13 | 43 | 132679 | 10725 | 79600941 |
Rales | 12.52 | 10.13 | 9 | 132713 | 19992 | 79591674 |
Personality disorder | 12.51 | 10.13 | 30 | 132692 | 6116 | 79605550 |
Pneumonia | 12.50 | 10.13 | 938 | 131784 | 659308 | 78952358 |
Plasma cell myeloma | 12.47 | 10.13 | 46 | 132676 | 53213 | 79558453 |
Partial seizures | 12.41 | 10.13 | 38 | 132684 | 8940 | 79602726 |
Renal tubular necrosis | 12.41 | 10.13 | 14 | 132708 | 25025 | 79586641 |
Hepatic failure | 12.37 | 10.13 | 56 | 132666 | 61156 | 79550510 |
Angina unstable | 12.37 | 10.13 | 6 | 132716 | 16521 | 79595145 |
Implant site warmth | 12.35 | 10.13 | 4 | 132718 | 37 | 79611629 |
Neuromuscular blocking therapy | 12.32 | 10.13 | 3 | 132719 | 8 | 79611658 |
Coagulopathy | 12.22 | 10.13 | 26 | 132696 | 35980 | 79575686 |
Procedural complication | 12.19 | 10.13 | 35 | 132687 | 7948 | 79603718 |
Diplegia | 12.14 | 10.13 | 15 | 132707 | 1788 | 79609878 |
Chronic fatigue syndrome | 12.09 | 10.13 | 13 | 132709 | 1334 | 79610332 |
Myocarditis | 12.08 | 10.13 | 11 | 132711 | 21722 | 79589944 |
Progressive relapsing multiple sclerosis | 12.08 | 10.13 | 4 | 132718 | 40 | 79611626 |
Medical device site haemorrhage | 12.07 | 10.13 | 6 | 132716 | 181 | 79611485 |
Visual impairment | 12.06 | 10.13 | 218 | 132504 | 91913 | 79519753 |
Implant site necrosis | 12.06 | 10.13 | 3 | 132719 | 9 | 79611657 |
Urine cannabinoids increased | 12.06 | 10.13 | 3 | 132719 | 9 | 79611657 |
Urine osmolarity increased | 12.00 | 10.13 | 7 | 132715 | 292 | 79611374 |
Malaise | 11.98 | 10.13 | 680 | 132042 | 489189 | 79122477 |
Logorrhoea | 11.95 | 10.13 | 24 | 132698 | 4341 | 79607325 |
Incontinence | 11.93 | 10.13 | 51 | 132671 | 14113 | 79597553 |
Device deposit issue | 11.90 | 10.13 | 4 | 132718 | 42 | 79611624 |
Calculus bladder | 11.89 | 10.13 | 13 | 132709 | 1359 | 79610307 |
Lower gastrointestinal haemorrhage | 11.85 | 10.13 | 6 | 132716 | 16119 | 79595547 |
Eyelid oedema | 11.82 | 10.13 | 4 | 132718 | 13683 | 79597983 |
Medical device site scab | 11.82 | 10.13 | 3 | 132719 | 10 | 79611656 |
Panniculitis | 11.81 | 10.13 | 3 | 132719 | 12368 | 79599298 |
Eosinophil percentage decreased | 11.73 | 10.13 | 7 | 132715 | 305 | 79611361 |
Somatosensory evoked potentials abnormal | 11.68 | 10.13 | 6 | 132716 | 194 | 79611472 |
Head injury | 11.67 | 10.13 | 104 | 132618 | 37265 | 79574401 |
Hypokalaemia | 11.67 | 10.13 | 169 | 132553 | 143871 | 79467795 |
Cerebral palsy | 11.66 | 10.13 | 6 | 132716 | 195 | 79611471 |
Limb discomfort | 11.62 | 10.13 | 94 | 132628 | 32756 | 79578910 |
Pituitary cyst | 11.60 | 10.13 | 3 | 132719 | 11 | 79611655 |
Hyperthermia | 11.57 | 10.13 | 60 | 132662 | 17977 | 79593689 |
Peripheral venous disease | 11.57 | 10.13 | 6 | 132716 | 15903 | 79595763 |
Allodynia | 11.56 | 10.13 | 14 | 132708 | 1634 | 79610032 |
Noninfective encephalitis | 11.51 | 10.13 | 9 | 132713 | 612 | 79611054 |
Aspergillus infection | 11.51 | 10.13 | 9 | 132713 | 19152 | 79592514 |
Pyrexia | 11.49 | 10.13 | 973 | 131749 | 677736 | 78933930 |
Aspartate aminotransferase increased | 11.46 | 10.13 | 162 | 132560 | 138479 | 79473187 |
Acute psychosis | 11.46 | 10.13 | 23 | 132699 | 4157 | 79607509 |
Tender joint count | 11.43 | 10.13 | 6 | 132716 | 203 | 79611463 |
Vasculitis | 11.42 | 10.13 | 15 | 132707 | 25087 | 79586579 |
Drug ineffective for unapproved indication | 11.40 | 10.13 | 133 | 132589 | 51105 | 79560561 |
Infusion site macule | 11.39 | 10.13 | 3 | 132719 | 12 | 79611654 |
Acute coronary syndrome | 11.39 | 10.13 | 11 | 132711 | 21122 | 79590544 |
Sedation complication | 11.39 | 10.13 | 54 | 132668 | 15615 | 79596051 |
Cataract | 11.30 | 10.13 | 59 | 132663 | 62061 | 79549605 |
Arteriosclerosis coronary artery | 11.25 | 10.13 | 59 | 132663 | 17757 | 79593909 |
Syringomyelia | 11.25 | 10.13 | 6 | 132716 | 210 | 79611456 |
Nodule | 11.24 | 10.13 | 13 | 132709 | 22981 | 79588685 |
Facial asymmetry | 11.22 | 10.13 | 10 | 132712 | 816 | 79610850 |
Fibromyalgia | 11.21 | 10.13 | 62 | 132660 | 64278 | 79547388 |
Ill-defined disorder | 11.20 | 10.13 | 64 | 132658 | 65811 | 79545855 |
Neuropsychiatric syndrome | 11.14 | 10.13 | 5 | 132717 | 119 | 79611547 |
Demyelination | 11.13 | 10.13 | 34 | 132688 | 7989 | 79603677 |
Consciousness fluctuating | 11.09 | 10.13 | 15 | 132707 | 1954 | 79609712 |
Mobility decreased | 11.08 | 10.13 | 274 | 132448 | 121901 | 79489765 |
Acquired diaphragmatic eventration | 11.05 | 10.13 | 9 | 132713 | 649 | 79611017 |
Acute respiratory distress syndrome | 11.03 | 10.13 | 37 | 132685 | 44030 | 79567636 |
Hyperuricaemia | 11.00 | 10.13 | 3 | 132719 | 11796 | 79599870 |
Tachycardia | 10.99 | 10.13 | 380 | 132342 | 177388 | 79434278 |
CD4 lymphocytes abnormal | 10.99 | 10.13 | 4 | 132718 | 54 | 79611612 |
Lip dry | 10.94 | 10.13 | 6 | 132716 | 15412 | 79596254 |
Decreased interest | 10.93 | 10.13 | 21 | 132701 | 3676 | 79607990 |
Lymphocyte count abnormal | 10.93 | 10.13 | 13 | 132709 | 1490 | 79610176 |
CD8 lymphocytes increased | 10.93 | 10.13 | 4 | 132718 | 55 | 79611611 |
Implant site pruritus | 10.92 | 10.13 | 8 | 132714 | 493 | 79611173 |
Anti-thyroid antibody positive | 10.92 | 10.13 | 8 | 132714 | 493 | 79611173 |
Anaphylactic reaction | 10.92 | 10.13 | 88 | 132634 | 83655 | 79528011 |
Blood potassium increased | 10.92 | 10.13 | 20 | 132702 | 29255 | 79582411 |
Urine uric acid decreased | 10.92 | 10.13 | 5 | 132717 | 125 | 79611541 |
Nerve compression | 10.87 | 10.13 | 37 | 132685 | 9202 | 79602464 |
Implant site pustules | 10.85 | 10.13 | 3 | 132719 | 15 | 79611651 |
Glaucoma | 10.84 | 10.13 | 63 | 132659 | 19698 | 79591968 |
Adrenal neoplasm | 10.81 | 10.13 | 8 | 132714 | 501 | 79611165 |
Fistula | 10.80 | 10.13 | 4 | 132718 | 12936 | 79598730 |
Hyperbilirubinaemia | 10.80 | 10.13 | 15 | 132707 | 24503 | 79587163 |
Hiccups | 10.79 | 10.13 | 39 | 132683 | 9992 | 79601674 |
Neuromuscular toxicity | 10.77 | 10.13 | 6 | 132716 | 229 | 79611437 |
Neoplasm malignant | 10.77 | 10.13 | 23 | 132699 | 31787 | 79579879 |
Mental disorder | 10.76 | 10.13 | 89 | 132633 | 31213 | 79580453 |
Enthesopathy | 10.73 | 10.13 | 43 | 132679 | 11565 | 79600101 |
SARS-CoV-2 antibody test negative | 10.70 | 10.13 | 6 | 132716 | 232 | 79611434 |
Intestinal perforation | 10.70 | 10.13 | 8 | 132714 | 17418 | 79594248 |
Septic shock | 10.69 | 10.13 | 142 | 132580 | 122659 | 79489007 |
Tuberculosis | 10.66 | 10.13 | 6 | 132716 | 15192 | 79596474 |
Fear of falling | 10.62 | 10.13 | 9 | 132713 | 686 | 79610980 |
Oxygen saturation decreased | 10.59 | 10.13 | 151 | 132571 | 128896 | 79482770 |
Red blood cell sedimentation rate increased | 10.55 | 10.13 | 40 | 132682 | 45902 | 79565764 |
Syncope | 10.54 | 10.13 | 223 | 132499 | 179226 | 79432440 |
Granulocytopenia | 10.49 | 10.13 | 3 | 132719 | 11428 | 79600238 |
Torsade de pointes | 10.47 | 10.13 | 10 | 132712 | 19302 | 79592364 |
Haemoglobin increased | 10.47 | 10.13 | 28 | 132694 | 6104 | 79605562 |
Spinal stenosis | 10.46 | 10.13 | 53 | 132669 | 15738 | 79595928 |
Rib fracture | 10.45 | 10.13 | 81 | 132641 | 27866 | 79583800 |
Invasive lobular breast carcinoma | 10.44 | 10.13 | 9 | 132713 | 702 | 79610964 |
Catheter site mass | 10.43 | 10.13 | 4 | 132718 | 63 | 79611603 |
Influenza B virus test positive | 10.43 | 10.13 | 7 | 132715 | 375 | 79611291 |
Lupus-like syndrome | 10.42 | 10.13 | 5 | 132717 | 13852 | 79597814 |
Hepatitis cholestatic | 10.41 | 10.13 | 5 | 132717 | 13847 | 79597819 |
Hepatic cirrhosis | 10.41 | 10.13 | 27 | 132695 | 34879 | 79576787 |
Athetosis | 10.40 | 10.13 | 5 | 132717 | 140 | 79611526 |
Osteoporosis postmenopausal | 10.39 | 10.13 | 3 | 132719 | 18 | 79611648 |
Viral titre decreased | 10.39 | 10.13 | 3 | 132719 | 18 | 79611648 |
Ischaemic stroke | 10.37 | 10.13 | 25 | 132697 | 33106 | 79578560 |
Gram stain positive | 10.33 | 10.13 | 5 | 132717 | 142 | 79611524 |
Intestinal polyp | 10.32 | 10.13 | 15 | 132707 | 2089 | 79609577 |
Spinal cord infection | 10.31 | 10.13 | 8 | 132714 | 538 | 79611128 |
Drug-induced liver injury | 10.31 | 10.13 | 66 | 132656 | 66051 | 79545615 |
Tongue biting | 10.23 | 10.13 | 15 | 132707 | 2106 | 79609560 |
None
Source | Code | Description |
---|---|---|
ATC | M03BX01 | MUSCULO-SKELETAL SYSTEM MUSCLE RELAXANTS MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS Other centrally acting agents |
FDA MoA | N0000000116 | GABA B Agonists |
FDA MoA | N0000000196 | GABA A Agonists |
CHEBI has role | CHEBI:35488 | central nervous system depressants |
CHEBI has role | CHEBI:51371 | muscle relaxants |
CHEBI has role | CHEBI:51373 | gamma-aminobutyric acid receptor agonist |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D018682 | GABA Agents |
MeSH PA | D018755 | GABA Agonists |
MeSH PA | D058786 | GABA-B Receptor Agonists |
MeSH PA | D009125 | Muscle Relaxants, Central |
MeSH PA | D009465 | Neuromuscular Agents |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
FDA EPC | N0000175759 | gamma-Aminobutyric Acid-ergic Agonist |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Muscle spasticity of spinal origin | indication | 416830008 | |
Muscle Spasticity of Cerebral Origin | indication | ||
Trigeminal neuralgia | off-label use | 31681005 | DOID:12098 |
Alcohol withdrawal syndrome | off-label use | 191480000 | |
Gastroesophageal reflux disease | off-label use | 235595009 | DOID:8534 |
Disorder of autonomic nervous system | contraindication | 15241006 | |
Schizophrenia | contraindication | 58214004 | DOID:5419 |
Psychotic disorder | contraindication | 69322001 | |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Autonomic dysreflexia | contraindication | 129618003 | |
Cerebrovascular accident | contraindication | 230690007 | |
Functional disorder of bladder neck and sphincter mechanism | contraindication | 236644005 | |
Impaired cognition | contraindication | 386806002 | |
Central nervous system depression | contraindication | 418072004 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 3.95 | acidic |
pKa2 | 9.54 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
25MG/5ML | FLEQSUVY | AZURITY | N215602 | Feb. 4, 2022 | RX | SUSPENSION | ORAL | 11446246 | Sept. 8, 2037 | INDICATED FOR THE TREATMENT OF SPASTICITY RESULTING FROM MULTIPLE SCLEROSIS |
10MG/PACKET | LYVISPAH | AMNEAL | N215422 | Nov. 22, 2021 | RX | GRANULES | ORAL | 10792262 | July 29, 2039 | METHOD FOR TREATING SPASTICITY |
20MG/PACKET | LYVISPAH | AMNEAL | N215422 | Nov. 22, 2021 | RX | GRANULES | ORAL | 10792262 | July 29, 2039 | METHOD FOR TREATING SPASTICITY |
5MG/PACKET | LYVISPAH | AMNEAL | N215422 | Nov. 22, 2021 | RX | GRANULES | ORAL | 10792262 | July 29, 2039 | METHOD FOR TREATING SPASTICITY |
5MG/5ML | OZOBAX | METACEL PHARMS LLC | N208193 | Sept. 18, 2019 | RX | SOLUTION | ORAL | 10610502 | Aug. 30, 2039 | TREATMENT OF SPASTICITY |
10MG/PACKET | LYVISPAH | AMNEAL | N215422 | Nov. 22, 2021 | RX | GRANULES | ORAL | 11491125 | Sept. 29, 2041 | TREATMENT OF SPASTICITY RESULTING FROM MULTIPLE SCLEROSIS, PARTICULARLY FOR THE RELIEF OF FLEXOR SPASMS AND CONCOMITANT PAIN, CLONUS, AND MUSCULAR RIGIDITY |
10MG/PACKET | LYVISPAH | AMNEAL | N215422 | Nov. 22, 2021 | RX | GRANULES | ORAL | 11491125 | Sept. 29, 2041 | TREATMENT OF SPASTICITY RESULTING FROM SPINAL CORD INJURIES AND OTHER SPINAL CORD DISEASES |
20MG/PACKET | LYVISPAH | AMNEAL | N215422 | Nov. 22, 2021 | RX | GRANULES | ORAL | 11491125 | Sept. 29, 2041 | TREATMENT OF SPASTICITY RESULTING FROM MULTIPLE SCLEROSIS, PARTICULARLY FOR THE RELIEF OF FLEXOR SPASMS AND CONCOMITANT PAIN, CLONUS, AND MUSCULAR RIGIDITY |
20MG/PACKET | LYVISPAH | AMNEAL | N215422 | Nov. 22, 2021 | RX | GRANULES | ORAL | 11491125 | Sept. 29, 2041 | TREATMENT OF SPASTICITY RESULTING FROM SPINAL CORD INJURIES AND OTHER SPINAL CORD DISEASES |
5MG/PACKET | LYVISPAH | AMNEAL | N215422 | Nov. 22, 2021 | RX | GRANULES | ORAL | 11491125 | Sept. 29, 2041 | TREATMENT OF SPASTICITY RESULTING FROM MULTIPLE SCLEROSIS, PARTICULARLY FOR THE RELIEF OF FLEXOR SPASMS AND CONCOMITANT PAIN, CLONUS, AND MUSCULAR RIGIDITY |
5MG/PACKET | LYVISPAH | AMNEAL | N215422 | Nov. 22, 2021 | RX | GRANULES | ORAL | 11491125 | Sept. 29, 2041 | TREATMENT OF SPASTICITY RESULTING FROM SPINAL CORD INJURIES AND OTHER SPINAL CORD DISEASES |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
25MG/5ML | BACLOFEN | SLAYBACK PHARMA LLC | A217252 | June 8, 2023 | RX | SUSPENSION | ORAL | Dec. 16, 2023 | PATENT CHALLENGE |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
GABA-B receptor | GPCR | AGONIST | IC50 | 7.46 | CHEMBL | CHEMBL | |||
Adenosine receptor A3 | GPCR | IC50 | 7.30 | CHEMBL | |||||
GABA-A receptor; anion channel | Ion channel | IC50 | 7.52 | CHEMBL | |||||
GABA B receptor | GPCR | IC50 | 7.52 | CHEMBL |
ID | Source |
---|---|
4018392 | VUID |
N0000146719 | NUI |
D00241 | KEGG_DRUG |
1292 | RXNORM |
C0004609 | UMLSCUI |
CHEBI:187893 | CHEBI |
2C0 | PDB_CHEM_ID |
CHEMBL701 | ChEMBL_ID |
DB00181 | DRUGBANK_ID |
D001418 | MESH_DESCRIPTOR_UI |
2284 | PUBCHEM_CID |
1084 | IUPHAR_LIGAND_ID |
2956 | INN_ID |
H789N3FKE8 | UNII |
1959 | MMSL |
4243 | MMSL |
709 | MMSL |
d00967 | MMSL |
387342009 | SNOMEDCT_US |
6102009 | SNOMEDCT_US |
4018392 | VANDF |
001677 | NDDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Baclofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1010 | TABLET | 10 mg | ORAL | ANDA | 11 sections |
Baclofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1010 | TABLET | 10 mg | ORAL | ANDA | 11 sections |
Baclofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1011 | TABLET | 5 mg | ORAL | ANDA | 11 sections |
Baclofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1011 | TABLET | 5 mg | ORAL | ANDA | 11 sections |
Baclofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1012 | TABLET | 20 mg | ORAL | ANDA | 11 sections |
Baclofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1012 | TABLET | 20 mg | ORAL | ANDA | 11 sections |
Baclofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0172-4096 | TABLET | 10 mg | ORAL | ANDA | 12 sections |
Baclofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0172-4097 | TABLET | 20 mg | ORAL | ANDA | 12 sections |
Baclofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-1330 | TABLET | 10 mg | ORAL | ANDA | 12 sections |
Baclofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-1333 | TABLET | 5 mg | ORAL | ANDA | 12 sections |
Baclofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-1337 | TABLET | 20 mg | ORAL | ANDA | 12 sections |
Baclofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0603-2406 | TABLET | 10 mg | ORAL | ANDA | 12 sections |
Baclofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0603-2406 | TABLET | 10 mg | ORAL | ANDA | 12 sections |
Baclofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0603-2407 | TABLET | 20 mg | ORAL | ANDA | 12 sections |
Baclofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0603-2407 | TABLET | 20 mg | ORAL | ANDA | 12 sections |
Baclofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-3541 | TABLET | 10 mg | ORAL | ANDA | 12 sections |
Baclofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-3542 | TABLET | 20 mg | ORAL | ANDA | 12 sections |
Baclofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8411 | TABLET | 10 mg | ORAL | ANDA | 11 sections |
Baclofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8411 | TABLET | 10 mg | ORAL | ANDA | 11 sections |
Baclofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8412 | TABLET | 20 mg | ORAL | ANDA | 11 sections |
Baclofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8412 | TABLET | 20 mg | ORAL | ANDA | 11 sections |
BACLOFEN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8466 | TABLET | 10 mg | ORAL | ANDA | 11 sections |
BACLOFEN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8467 | TABLET | 20 mg | ORAL | ANDA | 11 sections |
Baclofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-1054 | TABLET | 10 mg | ORAL | ANDA | 13 sections |
Baclofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-1054 | TABLET | 10 mg | ORAL | ANDA | 13 sections |
Baclofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-1055 | TABLET | 20 mg | ORAL | ANDA | 13 sections |
Baclofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-1055 | TABLET | 20 mg | ORAL | ANDA | 13 sections |
Baclofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6475 | TABLET | 10 mg | ORAL | ANDA | 12 sections |
Baclofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6475 | TABLET | 10 mg | ORAL | ANDA | 12 sections |
Baclofen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6476 | TABLET | 20 mg | ORAL | ANDA | 12 sections |