eperisone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	1022	64840-90-0

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

eperisone
(+/-)-Eperisone
eperisone hydrochloride
eperisone HCl

Molecular weight: 259.39
Formula: C17H25NO
CLOGP: 4.36
LIPINSKI: 0
HAC: 2
HDO: 0
TPSA: 20.31
ALOGS: -3.62
ROTB: 5

Drug dosage:

Dose	Unit	Route
0.15	g	O

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	5 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2B,AKT2,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,MAP3K7,MAPK10,MAPK12,MAPK7,MAPKAPK2,MET,NTRK2,PAK4,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK	39
kinase-selectivity-class	AXL,BRAF,EIF2AK3,EPHB4,GRK2,PDK4,SIK2,TTK	8
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Spinal compression fracture	38.00	34.99	11	767	15167	90612502

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypokalaemia	28.98	28.55	17	717	71704	42548897

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hepatic function abnormal	46.02	26.54	24	1689	89271	110498315
Spinal compression fracture	37	26.54	13	1700	18379	110569207
Hypokalaemia	36.94	26.54	27	1686	182421	110405165

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	M03BX09	MUSCULO-SKELETAL SYSTEM MUSCLE RELAXANTS MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS Other centrally acting agents
MeSH PA	D000077264	Calcium-Regulating Hormones and Agents
MeSH PA	D000927	Anticonvulsants
MeSH PA	D002121	Calcium Channel Blockers
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D009125	Muscle Relaxants, Central
MeSH PA	D009465	Neuromuscular Agents
MeSH PA	D010276	Parasympatholytics
MeSH PA	D014665	Vasodilator Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D049990	Membrane Transport Modulators
CHEBI has role	CHEBI:35480	analgesic
CHEBI has role	CHEBI:51371	muscle relaxant

Related Drugs by ATC class:

M03BX Other centrally acting agents 9 drugs

baclofen cyclobenzaprine fenyramidol mephenesin pridinol tetrazepam thiocolchicoside tizanidine tolperisone

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Spasm	indication	45352006

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.68	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Sigma non-opioid intracellular receptor 1	Membrane receptor	Q99720	SGMR1_HUMAN		Ki	8.77		DRUG MATRIX
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN		Ki	5.86		DRUG MATRIX
Muscarinic acetylcholine receptor M2	GPCR	P08172	ACM2_HUMAN		Ki	6.08		DRUG MATRIX
Cytochrome P450 2D6	Enzyme	P10635	CP2D6_HUMAN		IC50	5.31		DRUG MATRIX

External reference:

ID	Source
D01671	KEGG_DRUG
C0043606	UMLSCUI
CHEBI:77069	CHEBI
CHEMBL1902981	ChEMBL_ID
DB08992	DRUGBANK_ID
C030848	MESH_SUPPLEMENTAL_RECORD_UI
3236	PUBCHEM_CID
5153	INN_ID
56839-43-1	SECONDARY_CAS_RN
2M2P0551D3	UNII
010914	NDDF
010915	NDDF
1343341005	SNOMEDCT_US
1343537007	SNOMEDCT_US

Pharmaceutical products:

None