eperisone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1022 64840-90-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • eperisone
  • (+/-)-Eperisone
  • eperisone hydrochloride
  • eperisone HCl
  • Molecular weight: 259.39
  • Formula: C17H25NO
  • CLOGP: 4.36
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 20.31
  • ALOGS: -3.62
  • ROTB: 5

Drug dosage:

DoseUnitRoute
0.15 g O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypokalaemia 33.11 29.99 17 557 58197 34898160

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hepatic function abnormal 40.43 28.61 21 1290 73086 79669991
Hypokalaemia 38.88 28.61 26 1285 144014 79599063
Spinal compression fracture 33.48 28.61 12 1299 16946 79726131

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M03BX09 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
Other centrally acting agents
MeSH PA D000927 Anticonvulsants
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D009125 Muscle Relaxants, Central
MeSH PA D009465 Neuromuscular Agents
MeSH PA D010276 Parasympatholytics
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D014665 Vasodilator Agents
CHEBI has role CHEBI:51371 muscle relaxants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Spasm indication 45352006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.68 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 8.77 DRUG MATRIX
Alpha-2B adrenergic receptor GPCR Ki 5.86 DRUG MATRIX
Muscarinic acetylcholine receptor M2 GPCR Ki 6.08 DRUG MATRIX
Cytochrome P450 2D6 Enzyme IC50 5.31 DRUG MATRIX

External reference:

IDSource
D01671 KEGG_DRUG
C0043606 UMLSCUI
CHEBI:77069 CHEBI
CHEMBL1902981 ChEMBL_ID
DB08992 DRUGBANK_ID
C030848 MESH_SUPPLEMENTAL_RECORD_UI
3236 PUBCHEM_CID
5153 INN_ID
56839-43-1 SECONDARY_CAS_RN
2M2P0551D3 UNII
010914 NDDF
010915 NDDF

Pharmaceutical products:

None