Stem definition | Drug id | CAS RN |
---|---|---|
2683 | 51322-75-9 |
Dose | Unit | Route |
---|---|---|
12 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 2.36 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 21 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 2.40 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 11 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.70 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 2.40 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Nov. 27, 1996 | FDA | ACORDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Multiple sclerosis relapse | 361.18 | 10.92 | 307 | 46498 | 42657 | 50515662 |
Pneumonia aspiration | 223.30 | 10.92 | 203 | 46602 | 30801 | 50527518 |
Multiple sclerosis | 187.77 | 10.92 | 154 | 46651 | 20339 | 50537980 |
Gastrooesophageal reflux disease | 160.27 | 10.92 | 268 | 46537 | 76160 | 50482159 |
Somnolence | 141.34 | 10.92 | 387 | 46418 | 154598 | 50403721 |
Coma | 136.35 | 10.92 | 212 | 46593 | 56667 | 50501652 |
Completed suicide | 136.20 | 10.92 | 345 | 46460 | 131544 | 50426775 |
Contraindicated product administered | 107.18 | 10.92 | 8 | 46797 | 148950 | 50409369 |
Depression | 104.09 | 10.92 | 363 | 46442 | 165060 | 50393259 |
Synovitis | 97.28 | 10.92 | 4 | 46801 | 123861 | 50434458 |
Drug withdrawal syndrome | 95.61 | 10.92 | 117 | 46688 | 24964 | 50533355 |
Migraine | 87.28 | 10.92 | 206 | 46599 | 75074 | 50483245 |
Fall | 85.03 | 10.92 | 565 | 46240 | 334367 | 50223952 |
Glossodynia | 83.72 | 10.92 | 6 | 46799 | 115563 | 50442756 |
Maternal exposure during pregnancy | 82.16 | 10.92 | 23 | 46782 | 159755 | 50398564 |
Muscle spasms | 75.04 | 10.92 | 271 | 46534 | 125282 | 50433037 |
Systemic lupus erythematosus | 69.09 | 10.92 | 22 | 46783 | 140600 | 50417719 |
Hypoaesthesia | 68.00 | 10.92 | 265 | 46540 | 126992 | 50431327 |
Drug intolerance | 67.43 | 10.92 | 62 | 46743 | 219042 | 50339277 |
Lower respiratory tract infection | 63.40 | 10.92 | 7 | 46798 | 95194 | 50463125 |
Product dose omission issue | 62.50 | 10.92 | 335 | 46470 | 183503 | 50374816 |
Neutropenia | 61.45 | 10.92 | 30 | 46775 | 147935 | 50410384 |
Treatment failure | 60.11 | 10.92 | 26 | 46779 | 137611 | 50420708 |
Infusion related reaction | 59.63 | 10.92 | 42 | 46763 | 169515 | 50388804 |
Suspected suicide | 59.26 | 10.92 | 45 | 46760 | 5312 | 50553007 |
Pericarditis | 57.23 | 10.92 | 4 | 46801 | 78685 | 50479634 |
Urinary tract infection | 56.17 | 10.92 | 377 | 46428 | 223643 | 50334676 |
Exposure during pregnancy | 55.88 | 10.92 | 21 | 46784 | 120994 | 50437325 |
Withdrawal syndrome | 54.40 | 10.92 | 74 | 46731 | 17516 | 50540803 |
Gait disturbance | 54.16 | 10.92 | 278 | 46527 | 149727 | 50408592 |
Joint swelling | 45.12 | 10.92 | 100 | 46705 | 245186 | 50313133 |
Stiff person syndrome | 44.77 | 10.92 | 14 | 46791 | 217 | 50558102 |
Autonomic dysreflexia | 43.69 | 10.92 | 15 | 46790 | 316 | 50558003 |
Neck pain | 42.77 | 10.92 | 133 | 46672 | 56934 | 50501385 |
Thrombocytopenia | 41.83 | 10.92 | 34 | 46771 | 127639 | 50430680 |
General physical health deterioration | 39.57 | 10.92 | 44 | 46761 | 142390 | 50415929 |
Anxiety | 39.27 | 10.92 | 290 | 46515 | 177316 | 50381003 |
Febrile neutropenia | 38.75 | 10.92 | 21 | 46784 | 97646 | 50460673 |
Muscle spasticity | 38.31 | 10.92 | 62 | 46743 | 17122 | 50541197 |
Memory impairment | 37.38 | 10.92 | 159 | 46646 | 79201 | 50479118 |
Wound | 34.87 | 10.92 | 28 | 46777 | 105766 | 50452553 |
Helicobacter infection | 34.80 | 10.92 | 3 | 46802 | 49699 | 50508620 |
Tremor | 33.46 | 10.92 | 201 | 46604 | 114702 | 50443617 |
Drug ineffective | 33.31 | 10.92 | 546 | 46259 | 818787 | 49739532 |
Headache | 32.69 | 10.92 | 653 | 46152 | 505882 | 50052437 |
Pancytopenia | 31.99 | 10.92 | 19 | 46786 | 84011 | 50474308 |
Muscular weakness | 31.46 | 10.92 | 172 | 46633 | 94841 | 50463478 |
Back pain | 31.28 | 10.92 | 326 | 46479 | 219704 | 50338615 |
Malignant neoplasm progression | 31.14 | 10.92 | 12 | 46793 | 68112 | 50490207 |
Sleep apnoea syndrome | 30.60 | 10.92 | 68 | 46737 | 23800 | 50534519 |
Influenza like illness | 30.12 | 10.92 | 119 | 46686 | 57340 | 50500979 |
Feeling abnormal | 30.09 | 10.92 | 209 | 46596 | 125283 | 50433036 |
Dysphoria | 30.01 | 10.92 | 29 | 46776 | 4745 | 50553574 |
Paraesthesia | 29.26 | 10.92 | 201 | 46604 | 120042 | 50438277 |
Alopecia | 29.20 | 10.92 | 122 | 46683 | 244925 | 50313394 |
Intervertebral disc protrusion | 28.31 | 10.92 | 60 | 46745 | 20333 | 50537986 |
Insomnia | 28.20 | 10.92 | 266 | 46539 | 174599 | 50383720 |
Off label use | 28.10 | 10.92 | 292 | 46513 | 474134 | 50084185 |
Therapeutic product effect decreased | 27.94 | 10.92 | 52 | 46753 | 135998 | 50422321 |
Rash | 27.68 | 10.92 | 265 | 46540 | 437206 | 50121113 |
Hypersensitivity | 26.33 | 10.92 | 106 | 46699 | 215055 | 50343264 |
Folliculitis | 25.81 | 10.92 | 3 | 46802 | 39222 | 50519097 |
Vision blurred | 25.11 | 10.92 | 141 | 46664 | 78506 | 50479813 |
Amnesia | 25.02 | 10.92 | 91 | 46714 | 42169 | 50516150 |
Pain | 23.60 | 10.92 | 701 | 46104 | 578202 | 49980117 |
Therapy interrupted | 23.17 | 10.92 | 55 | 46750 | 20097 | 50538222 |
Neurogenic bladder | 23.13 | 10.92 | 20 | 46785 | 2837 | 50555482 |
Cardiac failure | 22.79 | 10.92 | 22 | 46783 | 76018 | 50482301 |
Vitamin D deficiency | 22.56 | 10.92 | 39 | 46766 | 11363 | 50546956 |
Arthropathy | 22.48 | 10.92 | 73 | 46732 | 157833 | 50400486 |
Lumbar radiculopathy | 22.31 | 10.92 | 16 | 46789 | 1730 | 50556589 |
Visual impairment | 22.19 | 10.92 | 123 | 46682 | 68152 | 50490167 |
Suspected product quality issue | 22.13 | 10.92 | 8 | 46797 | 197 | 50558122 |
Muscle injury | 21.74 | 10.92 | 4 | 46801 | 37107 | 50521212 |
Hallucination | 21.59 | 10.92 | 93 | 46712 | 46564 | 50511755 |
Hepatic enzyme increased | 21.35 | 10.92 | 61 | 46744 | 137319 | 50421000 |
JC polyomavirus test positive | 21.04 | 10.92 | 13 | 46792 | 1096 | 50557223 |
Suicidal ideation | 20.90 | 10.92 | 104 | 46701 | 55281 | 50503038 |
Blood pressure systolic increased | 20.38 | 10.92 | 4 | 46801 | 35445 | 50522874 |
Balance disorder | 20.23 | 10.92 | 123 | 46682 | 70467 | 50487852 |
COVID-19 | 20.07 | 10.92 | 91 | 46714 | 46571 | 50511748 |
Sleep disorder due to general medical condition, insomnia type | 19.28 | 10.92 | 3 | 46802 | 31444 | 50526875 |
Swelling | 19.27 | 10.92 | 108 | 46697 | 200764 | 50357555 |
Pre-existing condition improved | 19.19 | 10.92 | 28 | 46777 | 7069 | 50551250 |
C-reactive protein increased | 19.04 | 10.92 | 20 | 46785 | 66454 | 50491865 |
Formication | 18.98 | 10.92 | 20 | 46785 | 3626 | 50554693 |
Therapeutic response unexpected | 18.91 | 10.92 | 44 | 46761 | 15871 | 50542448 |
Therapy cessation | 18.91 | 10.92 | 60 | 46745 | 25951 | 50532368 |
Spinal operation | 18.85 | 10.92 | 26 | 46779 | 6234 | 50552085 |
Back disorder | 18.64 | 10.92 | 32 | 46773 | 9273 | 50549046 |
Drug dependence | 18.61 | 10.92 | 50 | 46755 | 19709 | 50538610 |
Rheumatoid arthritis | 18.31 | 10.92 | 111 | 46694 | 202439 | 50355880 |
Respiratory arrest | 18.08 | 10.92 | 65 | 46740 | 29944 | 50528375 |
Product use issue | 18.04 | 10.92 | 74 | 46731 | 149401 | 50408918 |
International normalised ratio increased | 17.52 | 10.92 | 9 | 46796 | 43143 | 50515176 |
Progressive multiple sclerosis | 17.32 | 10.92 | 10 | 46795 | 745 | 50557574 |
Intentional product misuse | 17.10 | 10.92 | 87 | 46718 | 46647 | 50511672 |
Surgery | 17.00 | 10.92 | 64 | 46741 | 30141 | 50528178 |
Nervousness | 16.75 | 10.92 | 60 | 46745 | 27591 | 50530728 |
Decreased interest | 16.71 | 10.92 | 17 | 46788 | 2959 | 50555360 |
Acute kidney injury | 16.66 | 10.92 | 133 | 46672 | 227925 | 50330394 |
Blood creatinine increased | 16.63 | 10.92 | 28 | 46777 | 76132 | 50482187 |
Abdominal discomfort | 16.50 | 10.92 | 136 | 46669 | 231505 | 50326814 |
Neuralgia | 16.41 | 10.92 | 51 | 46754 | 21812 | 50536507 |
Peroneal nerve palsy | 16.35 | 10.92 | 20 | 46785 | 4263 | 50554056 |
Anaemia | 16.32 | 10.92 | 152 | 46653 | 252304 | 50306015 |
Urinary incontinence | 16.07 | 10.92 | 60 | 46745 | 28148 | 50530171 |
Central nervous system lesion | 15.66 | 10.92 | 30 | 46775 | 9459 | 50548860 |
Dysarthria | 15.38 | 10.92 | 72 | 46733 | 37331 | 50520988 |
Disease progression | 15.31 | 10.92 | 42 | 46763 | 95824 | 50462495 |
Respiratory alkalosis | 15.27 | 10.92 | 15 | 46790 | 2504 | 50555815 |
Fibromyalgia | 15.26 | 10.92 | 82 | 46723 | 44896 | 50513423 |
Temperature intolerance | 15.20 | 10.92 | 26 | 46779 | 7513 | 50550806 |
Loss of consciousness | 14.98 | 10.92 | 155 | 46650 | 104198 | 50454121 |
Secondary progressive multiple sclerosis | 14.81 | 10.92 | 11 | 46794 | 1255 | 50557064 |
Intervertebral disc degeneration | 14.68 | 10.92 | 36 | 46769 | 13425 | 50544894 |
Dizziness | 14.48 | 10.92 | 421 | 46384 | 345948 | 50212371 |
Haemorrhagic diathesis | 14.37 | 10.92 | 18 | 46787 | 3930 | 50554389 |
Cholestasis | 14.32 | 10.92 | 3 | 46802 | 25398 | 50532921 |
Cardio-respiratory arrest | 14.25 | 10.92 | 92 | 46713 | 53800 | 50504519 |
Neutrophil count decreased | 14.16 | 10.92 | 13 | 46792 | 46013 | 50512306 |
Bone marrow failure | 14.14 | 10.92 | 4 | 46801 | 27620 | 50530699 |
Impaired healing | 14.03 | 10.92 | 27 | 46778 | 69759 | 50488560 |
Ankle fracture | 14.02 | 10.92 | 39 | 46766 | 15683 | 50542636 |
Mucosal inflammation | 14.02 | 10.92 | 10 | 46795 | 40132 | 50518187 |
Hyperhidrosis | 13.88 | 10.92 | 135 | 46670 | 89291 | 50469028 |
Pneumonitis | 13.81 | 10.92 | 5 | 46800 | 29505 | 50528814 |
Mental status changes | 13.61 | 10.92 | 68 | 46737 | 36204 | 50522115 |
Appetite disorder | 13.55 | 10.92 | 22 | 46783 | 6092 | 50552227 |
Pyrexia | 13.54 | 10.92 | 259 | 46546 | 379944 | 50178375 |
Device expulsion | 13.29 | 10.92 | 5 | 46800 | 28817 | 50529502 |
Hyperkalaemia | 13.18 | 10.92 | 15 | 46790 | 48074 | 50510245 |
Thinking abnormal | 13.11 | 10.92 | 28 | 46777 | 9539 | 50548780 |
Fibula fracture | 13.04 | 10.92 | 15 | 46790 | 2997 | 50555322 |
Illness | 13.00 | 10.92 | 51 | 46754 | 24489 | 50533830 |
Nasopharyngitis | 12.96 | 10.92 | 115 | 46690 | 192812 | 50365507 |
Optic neuritis | 12.90 | 10.92 | 23 | 46782 | 6867 | 50551452 |
Hepatocellular injury | 12.84 | 10.92 | 4 | 46801 | 25943 | 50532376 |
Nerve compression | 12.82 | 10.92 | 24 | 46781 | 7438 | 50550881 |
Spinal fusion acquired | 12.77 | 10.92 | 3 | 46802 | 14 | 50558305 |
Hypertonia | 12.72 | 10.92 | 17 | 46788 | 3956 | 50554363 |
Relapsing-remitting multiple sclerosis | 12.66 | 10.92 | 7 | 46798 | 480 | 50557839 |
Panic attack | 12.61 | 10.92 | 43 | 46762 | 19299 | 50539020 |
Cervical spinal stenosis | 12.58 | 10.92 | 12 | 46793 | 1931 | 50556388 |
Impaired gastric emptying | 12.51 | 10.92 | 26 | 46779 | 8692 | 50549627 |
Multiple organ dysfunction syndrome | 12.44 | 10.92 | 17 | 46788 | 50320 | 50507999 |
Ascites | 12.44 | 10.92 | 9 | 46796 | 35852 | 50522467 |
Loss of control of legs | 12.38 | 10.92 | 10 | 46795 | 1291 | 50557028 |
Normocytic anaemia | 12.21 | 10.92 | 10 | 46795 | 1317 | 50557002 |
Head injury | 11.98 | 10.92 | 49 | 46756 | 23971 | 50534348 |
Blood pressure orthostatic | 11.84 | 10.92 | 4 | 46801 | 80 | 50558239 |
Gastrointestinal haemorrhage | 11.80 | 10.92 | 32 | 46773 | 73289 | 50485030 |
Muscle tightness | 11.75 | 10.92 | 28 | 46777 | 10252 | 50548067 |
Spinal osteoarthritis | 11.64 | 10.92 | 34 | 46771 | 14058 | 50544261 |
Road traffic accident | 11.62 | 10.92 | 49 | 46756 | 24303 | 50534016 |
Urosepsis | 11.54 | 10.92 | 36 | 46769 | 15429 | 50542890 |
Underdose | 11.44 | 10.92 | 43 | 46762 | 20235 | 50538084 |
Drug dependence, antepartum | 11.28 | 10.92 | 3 | 46802 | 25 | 50558294 |
Gastrointestinal disorder | 11.24 | 10.92 | 47 | 46758 | 94409 | 50463910 |
Seizure | 11.21 | 10.92 | 162 | 46643 | 117712 | 50440607 |
Back injury | 11.20 | 10.92 | 22 | 46783 | 7063 | 50551256 |
Acute febrile neutrophilic dermatosis | 11.17 | 10.92 | 13 | 46792 | 2629 | 50555690 |
Loss of bladder sensation | 11.08 | 10.92 | 3 | 46802 | 27 | 50558292 |
Bronchitis | 11.06 | 10.92 | 146 | 46659 | 104013 | 50454306 |
Tremor neonatal | 11.05 | 10.92 | 4 | 46801 | 99 | 50558220 |
Diplopia | 11.00 | 10.92 | 41 | 46764 | 19219 | 50539100 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Multiple sclerosis relapse | 113.95 | 13.42 | 69 | 13567 | 11350 | 29549541 |
Multiple sclerosis | 110.24 | 13.42 | 53 | 13583 | 5501 | 29555390 |
Completed suicide | 96.27 | 13.42 | 159 | 13477 | 90087 | 29470804 |
Drug withdrawal syndrome | 73.16 | 13.42 | 63 | 13573 | 17921 | 29542970 |
Potassium wasting nephropathy | 65.39 | 13.42 | 14 | 13622 | 91 | 29560800 |
Muscle spasticity | 57.89 | 13.42 | 33 | 13603 | 4850 | 29556041 |
Failure to suspend medication | 55.92 | 13.42 | 16 | 13620 | 376 | 29560515 |
Depression | 46.99 | 13.42 | 114 | 13522 | 85033 | 29475858 |
Muscle spasms | 46.98 | 13.42 | 97 | 13539 | 64985 | 29495906 |
Back pain | 43.25 | 13.42 | 124 | 13512 | 102160 | 29458731 |
Intervertebral disc protrusion | 38.59 | 13.42 | 32 | 13604 | 8638 | 29552253 |
Febrile neutropenia | 35.15 | 13.42 | 5 | 13631 | 112235 | 29448656 |
Pain | 35.01 | 13.42 | 164 | 13472 | 171268 | 29389623 |
Urinary tract infection | 33.80 | 13.42 | 91 | 13545 | 72263 | 29488628 |
Suspected suicide | 31.84 | 13.42 | 21 | 13615 | 3999 | 29556892 |
Accidental death | 29.73 | 13.42 | 16 | 13620 | 2102 | 29558789 |
Wrong patient received product | 28.61 | 13.42 | 16 | 13620 | 2266 | 29558625 |
Anxiety | 28.18 | 13.42 | 95 | 13541 | 85270 | 29475621 |
Drug dependence | 27.92 | 13.42 | 41 | 13595 | 20940 | 29539951 |
Fall | 27.47 | 13.42 | 157 | 13479 | 177021 | 29383870 |
Progressive multiple sclerosis | 26.56 | 13.42 | 8 | 13628 | 226 | 29560665 |
Anaemia | 25.72 | 13.42 | 33 | 13603 | 200918 | 29359973 |
Gait disturbance | 25.43 | 13.42 | 83 | 13553 | 73266 | 29487625 |
Hypoaesthesia | 24.71 | 13.42 | 67 | 13569 | 53400 | 29507491 |
Inadequate analgesia | 23.82 | 13.42 | 15 | 13621 | 2639 | 29558252 |
Motor dysfunction | 22.54 | 13.42 | 20 | 13616 | 5910 | 29554981 |
Memory impairment | 22.45 | 13.42 | 51 | 13585 | 36419 | 29524472 |
Neuralgia | 21.82 | 13.42 | 26 | 13610 | 10848 | 29550043 |
Drug abuser | 21.05 | 13.42 | 16 | 13620 | 3811 | 29557080 |
Neutropenia | 20.91 | 13.42 | 18 | 13618 | 131693 | 29429198 |
Spinal cord injury cauda equina | 20.77 | 13.42 | 6 | 13630 | 146 | 29560745 |
Somatosensory evoked potentials abnormal | 20.54 | 13.42 | 6 | 13630 | 152 | 29560739 |
General physical health deterioration | 20.40 | 13.42 | 11 | 13625 | 102846 | 29458045 |
Autonomic dysreflexia | 19.97 | 13.42 | 5 | 13631 | 69 | 29560822 |
Vitamin B6 deficiency | 19.74 | 13.42 | 6 | 13630 | 175 | 29560716 |
Thrombocytopenia | 19.55 | 13.42 | 20 | 13616 | 134803 | 29426088 |
Dysdiadochokinesis | 19.21 | 13.42 | 6 | 13630 | 192 | 29560699 |
Urobilinogen urine increased | 19.14 | 13.42 | 7 | 13629 | 365 | 29560526 |
Drug tolerance | 18.90 | 13.42 | 12 | 13624 | 2141 | 29558750 |
Road traffic accident | 18.70 | 13.42 | 29 | 13607 | 15532 | 29545359 |
Movement disorder | 18.16 | 13.42 | 23 | 13613 | 10214 | 29550677 |
Kidney enlargement | 17.93 | 13.42 | 8 | 13628 | 699 | 29560192 |
Unemployment | 17.85 | 13.42 | 4 | 13632 | 33 | 29560858 |
Pancytopenia | 17.84 | 13.42 | 8 | 13628 | 83160 | 29477731 |
Blood folate increased | 17.65 | 13.42 | 6 | 13630 | 252 | 29560639 |
Sedation | 17.60 | 13.42 | 30 | 13606 | 17375 | 29543516 |
Insomnia | 17.40 | 13.42 | 84 | 13552 | 88677 | 29472214 |
Urine uric acid decreased | 17.37 | 13.42 | 5 | 13631 | 120 | 29560771 |
Urinary sediment abnormal | 17.22 | 13.42 | 5 | 13631 | 124 | 29560767 |
Pain in extremity | 17.17 | 13.42 | 98 | 13538 | 110335 | 29450556 |
Respiratory arrest | 16.87 | 13.42 | 37 | 13599 | 25796 | 29535095 |
Burning sensation | 16.82 | 13.42 | 28 | 13608 | 15910 | 29544981 |
Lipomatosis | 16.38 | 13.42 | 6 | 13630 | 314 | 29560577 |
Fear of falling | 16.10 | 13.42 | 6 | 13630 | 330 | 29560561 |
Secondary progressive multiple sclerosis | 15.63 | 13.42 | 6 | 13630 | 358 | 29560533 |
Muscle strength abnormal | 15.61 | 13.42 | 4 | 13632 | 61 | 29560830 |
Decreased vibratory sense | 15.50 | 13.42 | 6 | 13630 | 366 | 29560525 |
Respiratory paralysis | 15.49 | 13.42 | 4 | 13632 | 63 | 29560828 |
Implant site infection | 15.40 | 13.42 | 8 | 13628 | 978 | 29559913 |
Musculoskeletal stiffness | 15.39 | 13.42 | 45 | 13591 | 37413 | 29523478 |
Gait inability | 15.17 | 13.42 | 29 | 13607 | 18346 | 29542545 |
Mobility decreased | 14.70 | 13.42 | 35 | 13601 | 25745 | 29535146 |
Headache | 14.56 | 13.42 | 133 | 13503 | 173874 | 29387017 |
Fine motor skill dysfunction | 14.51 | 13.42 | 9 | 13627 | 1542 | 29559349 |
Malignant neoplasm progression | 14.49 | 13.42 | 8 | 13628 | 73851 | 29487040 |
Osteochondrosis | 13.92 | 13.42 | 7 | 13629 | 800 | 29560091 |
Cardio-respiratory arrest | 13.85 | 13.42 | 53 | 13583 | 50548 | 29510343 |
Muscular weakness | 13.83 | 13.42 | 61 | 13575 | 61991 | 29498900 |
Hyponatraemia | 13.75 | 13.42 | 7 | 13629 | 67626 | 29493265 |
Back injury | 13.74 | 13.42 | 12 | 13624 | 3472 | 29557419 |
Spinal fusion surgery | 13.58 | 13.42 | 7 | 13629 | 842 | 29560049 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Multiple sclerosis relapse | 369.40 | 11.09 | 278 | 47179 | 40857 | 64410418 |
Multiple sclerosis | 254.49 | 11.09 | 164 | 47293 | 18777 | 64432498 |
Completed suicide | 227.00 | 11.09 | 506 | 46951 | 223908 | 64227367 |
Drug withdrawal syndrome | 156.19 | 11.09 | 151 | 47306 | 31140 | 64420135 |
Pneumonia aspiration | 153.07 | 11.09 | 203 | 47254 | 59068 | 64392207 |
Gastrooesophageal reflux disease | 140.08 | 11.09 | 233 | 47224 | 82910 | 64368365 |
Somnolence | 118.47 | 11.09 | 374 | 47083 | 203271 | 64248004 |
Depression | 104.18 | 11.09 | 334 | 47123 | 182957 | 64268318 |
Urinary tract infection | 99.69 | 11.09 | 385 | 47072 | 231211 | 64220064 |
Coma | 99.16 | 11.09 | 207 | 47250 | 87408 | 64363867 |
Migraine | 96.76 | 11.09 | 169 | 47288 | 62508 | 64388767 |
Muscle spasms | 93.22 | 11.09 | 271 | 47186 | 140752 | 64310523 |
Fall | 89.46 | 11.09 | 568 | 46889 | 416258 | 64035017 |
Hypoaesthesia | 81.29 | 11.09 | 256 | 47201 | 138852 | 64312423 |
Suspected suicide | 78.75 | 11.09 | 59 | 47398 | 8595 | 64442680 |
Neutropenia | 77.17 | 11.09 | 40 | 47417 | 239584 | 64211691 |
Febrile neutropenia | 72.22 | 11.09 | 24 | 47433 | 187633 | 64263642 |
Muscle spasticity | 71.31 | 11.09 | 74 | 47383 | 16595 | 64434680 |
Gait disturbance | 67.43 | 11.09 | 278 | 47179 | 171877 | 64279398 |
Pain | 63.68 | 11.09 | 654 | 46803 | 552857 | 63898418 |
Autonomic dysreflexia | 59.88 | 11.09 | 19 | 47438 | 394 | 64450881 |
Intervertebral disc protrusion | 58.11 | 11.09 | 73 | 47384 | 20118 | 64431157 |
Thrombocytopenia | 56.42 | 11.09 | 49 | 47408 | 223752 | 64227523 |
General physical health deterioration | 56.25 | 11.09 | 41 | 47416 | 204384 | 64246891 |
Back pain | 54.82 | 11.09 | 343 | 47114 | 249828 | 64201447 |
Potassium wasting nephropathy | 52.68 | 11.09 | 14 | 47443 | 150 | 64451125 |
Neck pain | 50.38 | 11.09 | 128 | 47329 | 61405 | 64389870 |
Withdrawal syndrome | 49.48 | 11.09 | 73 | 47384 | 23419 | 64427856 |
Pancytopenia | 49.04 | 11.09 | 22 | 47435 | 143287 | 64307988 |
Lower respiratory tract infection | 46.58 | 11.09 | 7 | 47450 | 94607 | 64356668 |
Stiff person syndrome | 46.19 | 11.09 | 14 | 47443 | 248 | 64451027 |
Failure to suspend medication | 44.08 | 11.09 | 15 | 47442 | 390 | 64450885 |
Headache | 44.06 | 11.09 | 588 | 46869 | 528879 | 63922396 |
Product dose omission issue | 43.25 | 11.09 | 268 | 47189 | 194479 | 64256796 |
Off label use | 42.56 | 11.09 | 282 | 47175 | 632524 | 63818751 |
Acute kidney injury | 42.00 | 11.09 | 179 | 47278 | 449061 | 64002214 |
Contraindicated product administered | 39.40 | 11.09 | 15 | 47442 | 107814 | 64343461 |
Malignant neoplasm progression | 39.13 | 11.09 | 17 | 47440 | 112854 | 64338421 |
Memory impairment | 38.89 | 11.09 | 145 | 47312 | 85537 | 64365738 |
Insomnia | 37.10 | 11.09 | 261 | 47196 | 197575 | 64253700 |
Infusion related reaction | 35.70 | 11.09 | 41 | 47416 | 164426 | 64286849 |
Feeling abnormal | 34.93 | 11.09 | 192 | 47265 | 133410 | 64317865 |
Anxiety | 34.93 | 11.09 | 262 | 47195 | 202387 | 64248888 |
Pericarditis | 34.83 | 11.09 | 3 | 47454 | 62513 | 64388762 |
Cardiac failure | 34.54 | 11.09 | 28 | 47429 | 132345 | 64318930 |
Drug dependence | 34.54 | 11.09 | 76 | 47381 | 33236 | 64418039 |
Maternal exposure during pregnancy | 33.94 | 11.09 | 14 | 47443 | 95870 | 64355405 |
Anaemia | 33.48 | 11.09 | 154 | 47303 | 378526 | 64072749 |
Lumbar radiculopathy | 33.36 | 11.09 | 19 | 47438 | 1738 | 64449537 |
Glossodynia | 31.35 | 11.09 | 5 | 47452 | 64691 | 64386584 |
Influenza like illness | 31.04 | 11.09 | 108 | 47349 | 61594 | 64389681 |
Progressive multiple sclerosis | 31.02 | 11.09 | 14 | 47443 | 782 | 64450493 |
Visual impairment | 30.05 | 11.09 | 121 | 47336 | 73956 | 64377319 |
Muscular weakness | 30.00 | 11.09 | 178 | 47279 | 127160 | 64324115 |
Drug intolerance | 29.98 | 11.09 | 58 | 47399 | 187934 | 64263341 |
Treatment failure | 28.90 | 11.09 | 26 | 47431 | 116790 | 64334485 |
Blood creatinine increased | 27.20 | 11.09 | 36 | 47421 | 135746 | 64315529 |
Neurogenic bladder | 27.12 | 11.09 | 22 | 47435 | 3597 | 64447678 |
Respiratory arrest | 26.01 | 11.09 | 92 | 47365 | 52893 | 64398382 |
Road traffic accident | 24.17 | 11.09 | 63 | 47394 | 30682 | 64420593 |
Cardio-respiratory arrest | 24.12 | 11.09 | 139 | 47318 | 98254 | 64353021 |
Mucosal inflammation | 24.06 | 11.09 | 8 | 47449 | 62576 | 64388699 |
Platelet count decreased | 24.00 | 11.09 | 55 | 47402 | 167656 | 64283619 |
Dysphoria | 23.45 | 11.09 | 22 | 47435 | 4366 | 64446909 |
Drug abuser | 23.44 | 11.09 | 25 | 47432 | 5783 | 64445492 |
Urinary incontinence | 23.39 | 11.09 | 69 | 47388 | 36082 | 64415193 |
Hyperkalaemia | 23.28 | 11.09 | 24 | 47433 | 101105 | 64350170 |
Hypersensitivity | 23.13 | 11.09 | 71 | 47386 | 196381 | 64254894 |
JC polyomavirus test positive | 22.24 | 11.09 | 13 | 47444 | 1249 | 64450026 |
Neuralgia | 21.98 | 11.09 | 55 | 47402 | 26129 | 64425146 |
Inadequate analgesia | 21.37 | 11.09 | 20 | 47437 | 3958 | 64447317 |
Mental status changes | 21.01 | 11.09 | 95 | 47362 | 61067 | 64390208 |
Tremor | 20.83 | 11.09 | 183 | 47274 | 148047 | 64303228 |
Exposure during pregnancy | 20.80 | 11.09 | 16 | 47441 | 77659 | 64373616 |
Bone marrow failure | 20.52 | 11.09 | 5 | 47452 | 47947 | 64403328 |
International normalised ratio increased | 20.33 | 11.09 | 17 | 47440 | 79150 | 64372125 |
Dizziness | 20.31 | 11.09 | 436 | 47021 | 429727 | 64021548 |
Multiple organ dysfunction syndrome | 20.20 | 11.09 | 27 | 47430 | 101386 | 64349889 |
Joint swelling | 19.96 | 11.09 | 86 | 47371 | 215296 | 64235979 |
Paraesthesia | 19.91 | 11.09 | 168 | 47289 | 134354 | 64316921 |
Peroneal nerve palsy | 19.90 | 11.09 | 22 | 47435 | 5299 | 64445976 |
Vision blurred | 19.84 | 11.09 | 124 | 47333 | 90192 | 64361083 |
Secondary progressive multiple sclerosis | 19.81 | 11.09 | 12 | 47445 | 1231 | 64450044 |
Systemic lupus erythematosus | 19.52 | 11.09 | 17 | 47440 | 77595 | 64373680 |
Gait inability | 19.46 | 11.09 | 72 | 47385 | 42296 | 64408979 |
Back injury | 19.14 | 11.09 | 26 | 47431 | 7731 | 64443544 |
Hallucination | 18.60 | 11.09 | 104 | 47353 | 72684 | 64378591 |
Muscle tightness | 18.49 | 11.09 | 31 | 47426 | 11084 | 64440191 |
Gastrointestinal haemorrhage | 18.44 | 11.09 | 44 | 47413 | 132268 | 64319007 |
Disease progression | 18.29 | 11.09 | 49 | 47408 | 141631 | 64309644 |
Urinary sediment abnormal | 18.29 | 11.09 | 6 | 47451 | 139 | 64451136 |
Back disorder | 18.16 | 11.09 | 29 | 47428 | 9961 | 64441314 |
Amnesia | 18.12 | 11.09 | 77 | 47380 | 48192 | 64403083 |
Dysarthria | 18.02 | 11.09 | 89 | 47368 | 59317 | 64391958 |
Spinal cord injury cauda equina | 18.01 | 11.09 | 6 | 47451 | 146 | 64451129 |
Pyrexia | 18.00 | 11.09 | 296 | 47161 | 558348 | 63892927 |
Toxic epidermal necrolysis | 17.72 | 11.09 | 3 | 47454 | 37163 | 64414112 |
Ascites | 17.61 | 11.09 | 12 | 47445 | 61989 | 64389286 |
Panic attack | 17.57 | 11.09 | 44 | 47413 | 20909 | 64430366 |
Spinal osteoarthritis | 17.53 | 11.09 | 35 | 47422 | 14306 | 64436969 |
Vitamin D deficiency | 17.35 | 11.09 | 31 | 47426 | 11661 | 64439614 |
Drug hypersensitivity | 17.23 | 11.09 | 258 | 47199 | 237557 | 64213718 |
Intervertebral disc degeneration | 17.22 | 11.09 | 33 | 47424 | 13087 | 64438188 |
Hyponatraemia | 17.18 | 11.09 | 54 | 47403 | 148285 | 64302990 |
Balance disorder | 17.06 | 11.09 | 113 | 47344 | 83813 | 64367462 |
Hepatocellular injury | 17.01 | 11.09 | 6 | 47451 | 45229 | 64406046 |
Somatosensory evoked potentials abnormal | 16.79 | 11.09 | 6 | 47451 | 181 | 64451094 |
Accidental death | 16.77 | 11.09 | 17 | 47440 | 3708 | 64447567 |
Surgery | 16.52 | 11.09 | 52 | 47405 | 28161 | 64423114 |
Renal impairment | 16.46 | 11.09 | 48 | 47409 | 134969 | 64316306 |
Thinking abnormal | 16.33 | 11.09 | 30 | 47427 | 11526 | 64439749 |
Formication | 16.27 | 11.09 | 18 | 47439 | 4339 | 64446936 |
Atrial fibrillation | 16.04 | 11.09 | 68 | 47389 | 171021 | 64280254 |
Neutrophil count decreased | 15.94 | 11.09 | 20 | 47437 | 77176 | 64374099 |
Pain in extremity | 15.86 | 11.09 | 312 | 47145 | 302773 | 64148502 |
Melaena | 15.70 | 11.09 | 10 | 47447 | 53538 | 64397737 |
Therapy interrupted | 15.69 | 11.09 | 41 | 47416 | 19995 | 64431280 |
Cytomegalovirus infection | 15.68 | 11.09 | 4 | 47453 | 37195 | 64414080 |
Therapy cessation | 15.59 | 11.09 | 56 | 47401 | 32433 | 64418842 |
Burning sensation | 15.49 | 11.09 | 75 | 47382 | 49589 | 64401686 |
C-reactive protein increased | 15.37 | 11.09 | 29 | 47428 | 94880 | 64356395 |
Urobilinogen urine increased | 15.23 | 11.09 | 8 | 47449 | 624 | 64450651 |
Movement disorder | 15.21 | 11.09 | 43 | 47414 | 21957 | 64429318 |
Urine uric acid decreased | 15.07 | 11.09 | 5 | 47452 | 120 | 64451155 |
Angioedema | 15 | 11.09 | 14 | 47443 | 61807 | 64389468 |
Renal failure | 14.80 | 11.09 | 76 | 47381 | 181612 | 64269663 |
Bladder disorder | 14.74 | 11.09 | 23 | 47434 | 7744 | 64443531 |
Unemployment | 14.64 | 11.09 | 4 | 47453 | 48 | 64451227 |
Spinal operation | 14.29 | 11.09 | 20 | 47437 | 6113 | 64445162 |
Vitamin B6 deficiency | 14.21 | 11.09 | 6 | 47451 | 285 | 64450990 |
Motor dysfunction | 14.19 | 11.09 | 28 | 47429 | 11345 | 64439930 |
Loss of control of legs | 14.17 | 11.09 | 11 | 47446 | 1688 | 64449587 |
Productive cough | 14.06 | 11.09 | 20 | 47437 | 73183 | 64378092 |
Nerve compression | 14.03 | 11.09 | 22 | 47435 | 7439 | 64443836 |
Paraparesis | 14.00 | 11.09 | 15 | 47442 | 3487 | 64447788 |
Bedridden | 13.98 | 11.09 | 26 | 47431 | 10083 | 64441192 |
Leukopenia | 13.84 | 11.09 | 34 | 47423 | 101208 | 64350067 |
Arterial perforation | 13.83 | 11.09 | 3 | 47454 | 12 | 64451263 |
Fibula fracture | 13.73 | 11.09 | 14 | 47443 | 3074 | 64448201 |
Dysdiadochokinesis | 13.72 | 11.09 | 6 | 47451 | 311 | 64450964 |
Respiratory paralysis | 13.63 | 11.09 | 4 | 47453 | 63 | 64451212 |
Circulatory collapse | 13.52 | 11.09 | 4 | 47453 | 33728 | 64417547 |
Appetite disorder | 13.49 | 11.09 | 20 | 47437 | 6441 | 64444834 |
Interstitial lung disease | 13.22 | 11.09 | 33 | 47424 | 97699 | 64353576 |
Product quality issue | 13.15 | 11.09 | 50 | 47407 | 29749 | 64421526 |
Wrong patient received product | 13.12 | 11.09 | 15 | 47442 | 3747 | 64447528 |
Concussion | 13.02 | 11.09 | 22 | 47435 | 7916 | 64443359 |
Haemoglobin decreased | 13.01 | 11.09 | 87 | 47370 | 194976 | 64256299 |
Asthenia | 12.92 | 11.09 | 409 | 47048 | 427635 | 64023640 |
Haemorrhagic diathesis | 12.88 | 11.09 | 18 | 47439 | 5496 | 64445779 |
pH urine decreased | 12.82 | 11.09 | 3 | 47454 | 18 | 64451257 |
Head injury | 12.80 | 11.09 | 53 | 47404 | 32789 | 64418486 |
Intentional product misuse | 12.73 | 11.09 | 94 | 47363 | 72201 | 64379074 |
Pneumonitis | 12.70 | 11.09 | 11 | 47446 | 50354 | 64400921 |
Fibromyalgia | 12.64 | 11.09 | 56 | 47401 | 35675 | 64415600 |
Epistaxis | 12.61 | 11.09 | 34 | 47423 | 98097 | 64353178 |
Lipomatosis | 12.54 | 11.09 | 6 | 47451 | 383 | 64450892 |
Septic shock | 12.47 | 11.09 | 38 | 47419 | 105399 | 64345876 |
Ankle fracture | 12.45 | 11.09 | 31 | 47426 | 14679 | 64436596 |
Hepatotoxicity | 12.36 | 11.09 | 7 | 47450 | 39955 | 64411320 |
Device allergy | 12.30 | 11.09 | 3 | 47454 | 22 | 64451253 |
Osteonecrosis of jaw | 12.29 | 11.09 | 7 | 47450 | 39818 | 64411457 |
Nerve injury | 12.21 | 11.09 | 21 | 47436 | 7664 | 64443611 |
Implant site infection | 12.20 | 11.09 | 10 | 47447 | 1659 | 64449616 |
Lymphocyte percentage decreased | 12.11 | 11.09 | 16 | 47441 | 4633 | 64446642 |
Implant site swelling | 12.07 | 11.09 | 6 | 47451 | 417 | 64450858 |
Stress | 12.00 | 11.09 | 81 | 47376 | 60453 | 64390822 |
CSF immunoglobulin increased | 11.96 | 11.09 | 3 | 47454 | 25 | 64451250 |
Drug dependence, antepartum | 11.96 | 11.09 | 3 | 47454 | 25 | 64451250 |
Hepatic enzyme increased | 11.96 | 11.09 | 52 | 47405 | 129891 | 64321384 |
Tibia fracture | 11.85 | 11.09 | 16 | 47441 | 4729 | 64446546 |
Spinal fusion surgery | 11.80 | 11.09 | 14 | 47443 | 3637 | 64447638 |
Tubulointerstitial nephritis | 11.79 | 11.09 | 4 | 47453 | 30905 | 64420370 |
Nervousness | 11.76 | 11.09 | 48 | 47409 | 29508 | 64421767 |
White blood cells urine positive | 11.69 | 11.09 | 17 | 47440 | 5381 | 64445894 |
Loss of consciousness | 11.54 | 11.09 | 163 | 47294 | 148202 | 64303073 |
Medical device site pain | 11.51 | 11.09 | 5 | 47452 | 255 | 64451020 |
Acute myeloid leukaemia | 11.49 | 11.09 | 3 | 47454 | 27460 | 64423815 |
Neurotoxicity | 11.45 | 11.09 | 3 | 47454 | 27401 | 64423874 |
Kidney enlargement | 11.43 | 11.09 | 8 | 47449 | 1048 | 64450227 |
Agranulocytosis | 11.40 | 11.09 | 7 | 47450 | 38222 | 64413053 |
Injection site bruising | 11.39 | 11.09 | 55 | 47402 | 36318 | 64414957 |
Impaired gastric emptying | 11.38 | 11.09 | 22 | 47435 | 8782 | 64442493 |
Muscle strength abnormal | 11.38 | 11.09 | 4 | 47453 | 115 | 64451160 |
Mucosa vesicle | 11.30 | 11.09 | 3 | 47454 | 32 | 64451243 |
Blood folate increased | 11.29 | 11.09 | 6 | 47451 | 479 | 64450796 |
T-lymphocyte count decreased | 11.27 | 11.09 | 6 | 47451 | 481 | 64450794 |
Bronchitis | 11.25 | 11.09 | 126 | 47331 | 108617 | 64342658 |
Acute febrile neutrophilic dermatosis | 11.15 | 11.09 | 13 | 47444 | 3316 | 64447959 |
Temperature intolerance | 11.13 | 11.09 | 21 | 47436 | 8234 | 64443041 |
Intervertebral disc disorder | 11.09 | 11.09 | 15 | 47442 | 4442 | 64446833 |
None
Source | Code | Description |
---|---|---|
ATC | M03BX02 | MUSCULO-SKELETAL SYSTEM MUSCLE RELAXANTS MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS Other centrally acting agents |
FDA MoA | N0000009918 | Adrenergic alpha2-Agonists |
FDA EPC | N0000175554 | Central alpha-2 Adrenergic Agonist |
MeSH PA | D018663 | Adrenergic Agents |
MeSH PA | D000322 | Adrenergic Agonists |
MeSH PA | D058647 | Adrenergic alpha-2 Receptor Agonists |
MeSH PA | D000316 | Adrenergic alpha-Agonists |
MeSH PA | D000700 | Analgesics |
MeSH PA | D000927 | Anticonvulsants |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D009125 | Muscle Relaxants, Central |
MeSH PA | D009465 | Neuromuscular Agents |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D010276 | Parasympatholytics |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D018689 | Sensory System Agents |
CHEBI has role | CHEBI:35569 | alpha-adrenergic agonists |
CHEBI has role | CHEBI:51371 | muscle relaxants |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Spasticity | indication | 221360009 | |
Muscle spasticity of spinal origin | indication | 416830008 | |
Muscle Spasticity of Cerebral Origin | indication | ||
Low blood pressure | contraindication | 45007003 | |
Bradycardia | contraindication | 48867003 | |
Hepatic failure | contraindication | 59927004 | |
Psychotic disorder | contraindication | 69322001 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.01 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Alpha-2A adrenergic receptor | GPCR | AGONIST | EC50 | 7.07 | CHEMBL | CHEMBL | |||
Alpha-2B adrenergic receptor | GPCR | AGONIST | WOMBAT-PK | CHEMBL | |||||
Alpha-2C adrenergic receptor | GPCR | AGONIST | EC50 | 5.91 | CHEMBL | CHEMBL | |||
Nischarin | Membrane receptor | Ki | 7.55 | CHEMBL | |||||
Alpha-1A adrenergic receptor | GPCR | EC50 | 6.58 | CHEMBL | |||||
Alpha-1B adrenergic receptor | GPCR | EC50 | 6.49 | CHEMBL |
ID | Source |
---|---|
4021025 | VUID |
N0000148492 | NUI |
D00776 | KEGG_DRUG |
64461-82-1 | SECONDARY_CAS_RN |
4021025 | VANDF |
4021027 | VANDF |
C0146011 | UMLSCUI |
CHEBI:63629 | CHEBI |
CHEMBL1079 | ChEMBL_ID |
CHEMBL1200329 | ChEMBL_ID |
DB00697 | DRUGBANK_ID |
C023754 | MESH_SUPPLEMENTAL_RECORD_UI |
5487 | PUBCHEM_CID |
7308 | IUPHAR_LIGAND_ID |
4697 | INN_ID |
6AI06C00GW | UNII |
236460 | RXNORM |
22951 | MMSL |
44068 | MMSL |
5589 | MMSL |
d04102 | MMSL |
006021 | NDDF |
006022 | NDDF |
108461005 | SNOMEDCT_US |
108462003 | SNOMEDCT_US |
373440006 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
tizanidine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0034 | TABLET | 2 mg | ORAL | ANDA | 27 sections |
tizanidine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-4400 | TABLET | 4 mg | ORAL | ANDA | 27 sections |
tizanidine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-2788 | CAPSULE, GELATIN COATED | 2 mg | ORAL | NDA | 26 sections |
tizanidine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-2789 | CAPSULE, GELATIN COATED | 4 mg | ORAL | NDA | 26 sections |
tizanidine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-2790 | CAPSULE, GELATIN COATED | 6 mg | ORAL | NDA | 26 sections |
Tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-5574 | TABLET | 4 mg | ORAL | ANDA | 25 sections |
Tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-6564 | TABLET | 2 mg | ORAL | ANDA | 25 sections |
Tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8274 | TABLET | 4 mg | ORAL | ANDA | 27 sections |
Tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8360 | TABLET | 2 mg | ORAL | ANDA | 27 sections |
tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6418 | TABLET | 4 mg | ORAL | ANDA | 18 sections |
tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6418 | TABLET | 4 mg | ORAL | ANDA | 18 sections |
Tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6898 | TABLET | 4 mg | ORAL | ANDA | 27 sections |
tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-576 | TABLET | 4 mg | ORAL | ANDA | 20 sections |
tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-587 | TABLET | 2 mg | ORAL | ANDA | 18 sections |
tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-863 | TABLET | 2 mg | ORAL | ANDA | 18 sections |
Tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-890 | TABLET | 4 mg | ORAL | ANDA | 22 sections |
TIZANIDINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-220 | TABLET | 2 mg | ORAL | ANDA | 16 sections |
TIZANIDINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-221 | TABLET | 4 mg | ORAL | ANDA | 16 sections |
ZANAFLEX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-756 | CAPSULE | 6 mg | ORAL | NDA | 24 sections |
ZANAFLEX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-871 | CAPSULE | 4 mg | ORAL | NDA | 24 sections |
Tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-171 | TABLET | 2 mg | ORAL | ANDA | 27 sections |
Tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-172 | TABLET | 4 mg | ORAL | ANDA | 27 sections |
TIZANIDINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-126 | TABLET | 2 mg | ORAL | ANDA | 24 sections |
TIZANIDINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-127 | TABLET | 4 mg | ORAL | ANDA | 24 sections |
Zanaflex | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-373 | CAPSULE, GELATIN COATED | 4 mg | ORAL | NDA | 26 sections |
Tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 29300-168 | TABLET | 2 mg | ORAL | ANDA | 26 sections |
Tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 29300-169 | TABLET | 4 mg | ORAL | ANDA | 26 sections |
Tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-103 | TABLET | 2 mg | ORAL | ANDA | 22 sections |
Tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-104 | TABLET | 4 mg | ORAL | ANDA | 22 sections |
Tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 35356-662 | TABLET | 2 mg | ORAL | ANDA | 27 sections |