Stem definition | Drug id | CAS RN |
---|---|---|
2683 | 51322-75-9 |
Dose | Unit | Route |
---|---|---|
12 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 2.36 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 21 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 2.40 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 11 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.70 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 2.40 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Nov. 27, 1996 | FDA | ACORDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Multiple sclerosis relapse | 375.20 | 10.37 | 312 | 48822 | 44591 | 56198342 |
Pneumonia aspiration | 237.59 | 10.37 | 209 | 48925 | 32202 | 56210731 |
Multiple sclerosis | 168.12 | 10.37 | 161 | 48973 | 27641 | 56215292 |
Gastrooesophageal reflux disease | 168.09 | 10.37 | 278 | 48856 | 82979 | 56159954 |
Somnolence | 157.86 | 10.37 | 402 | 48732 | 163011 | 56079922 |
Completed suicide | 148.15 | 10.37 | 347 | 48787 | 133486 | 56109447 |
Coma | 146.51 | 10.37 | 218 | 48916 | 59437 | 56183496 |
Contraindicated product administered | 124.95 | 10.37 | 10 | 49124 | 186276 | 56056657 |
Synovitis | 122.74 | 10.37 | 4 | 49130 | 161301 | 56081632 |
Muscle spasms | 114.44 | 10.37 | 320 | 48814 | 137051 | 56105882 |
Glossodynia | 108.64 | 10.37 | 6 | 49128 | 152452 | 56090481 |
Depression | 106.09 | 10.37 | 372 | 48762 | 179745 | 56063188 |
Hand deformity | 103.52 | 10.37 | 3 | 49131 | 134489 | 56108444 |
Drug withdrawal syndrome | 98.19 | 10.37 | 117 | 49017 | 25740 | 56217193 |
Migraine | 98.10 | 10.37 | 227 | 48907 | 86570 | 56156363 |
Rheumatoid arthritis | 97.92 | 10.37 | 114 | 49020 | 382490 | 55860443 |
Fall | 94.82 | 10.37 | 584 | 48550 | 356926 | 55886007 |
Systemic lupus erythematosus | 92.11 | 10.37 | 22 | 49112 | 180056 | 56062877 |
Maternal exposure during pregnancy | 87.90 | 10.37 | 28 | 49106 | 189525 | 56053408 |
Drug intolerance | 86.54 | 10.37 | 63 | 49071 | 264755 | 55978178 |
Pericarditis | 78.48 | 10.37 | 4 | 49130 | 108919 | 56134014 |
Product dose omission issue | 76.88 | 10.37 | 368 | 48766 | 204385 | 56038548 |
Treatment failure | 75.81 | 10.37 | 27 | 49107 | 170365 | 56072568 |
Lower respiratory tract infection | 74.66 | 10.37 | 7 | 49127 | 114787 | 56128146 |
Infusion related reaction | 69.15 | 10.37 | 49 | 49085 | 208882 | 56034051 |
Hypoaesthesia | 68.88 | 10.37 | 275 | 48859 | 141216 | 56101717 |
Urinary tract infection | 64.33 | 10.37 | 394 | 48740 | 240119 | 56002814 |
Neutropenia | 60.87 | 10.37 | 31 | 49103 | 158136 | 56084797 |
Suspected suicide | 60.77 | 10.37 | 45 | 49089 | 5421 | 56237512 |
Joint swelling | 59.46 | 10.37 | 101 | 49033 | 289699 | 55953234 |
Withdrawal syndrome | 58.03 | 10.37 | 76 | 49058 | 18386 | 56224547 |
Gait disturbance | 57.30 | 10.37 | 288 | 48846 | 163033 | 56079900 |
Exposure during pregnancy | 56.67 | 10.37 | 24 | 49110 | 136318 | 56106615 |
Wound | 52.23 | 10.37 | 28 | 49106 | 138776 | 56104157 |
Helicobacter infection | 51.81 | 10.37 | 3 | 49131 | 73265 | 56169668 |
Neck pain | 49.82 | 10.37 | 142 | 48992 | 61413 | 56181520 |
General physical health deterioration | 49.81 | 10.37 | 45 | 49089 | 169965 | 56072968 |
Muscle spasticity | 44.80 | 10.37 | 70 | 49064 | 19890 | 56223043 |
Autonomic dysreflexia | 44.45 | 10.37 | 15 | 49119 | 318 | 56242615 |
Anxiety | 41.65 | 10.37 | 300 | 48834 | 192872 | 56050061 |
Headache | 41.02 | 10.37 | 700 | 48434 | 558344 | 55684589 |
Tremor | 40.68 | 10.37 | 211 | 48923 | 120878 | 56122055 |
Febrile neutropenia | 40.13 | 10.37 | 21 | 49113 | 105524 | 56137409 |
Thrombocytopenia | 39.96 | 10.37 | 36 | 49098 | 136188 | 56106745 |
Stiff person syndrome | 39.86 | 10.37 | 14 | 49120 | 336 | 56242597 |
Therapeutic product effect decreased | 39.59 | 10.37 | 54 | 49080 | 169398 | 56073535 |
Memory impairment | 39.52 | 10.37 | 165 | 48969 | 86392 | 56156541 |
Back pain | 38.42 | 10.37 | 345 | 48789 | 236825 | 56006108 |
Folliculitis | 36.69 | 10.37 | 3 | 49131 | 54976 | 56187957 |
Drug ineffective | 36.58 | 10.37 | 574 | 48560 | 918415 | 55324518 |
Arthropathy | 36.45 | 10.37 | 75 | 49059 | 200200 | 56042733 |
Off label use | 35.39 | 10.37 | 313 | 48821 | 555867 | 55687066 |
Alopecia | 34.83 | 10.37 | 135 | 48999 | 293323 | 55949610 |
Hypersensitivity | 34.40 | 10.37 | 112 | 49022 | 256296 | 55986637 |
Muscular weakness | 33.69 | 10.37 | 180 | 48954 | 104272 | 56138661 |
Feeling abnormal | 33.24 | 10.37 | 215 | 48919 | 133387 | 56109546 |
Influenza like illness | 32.46 | 10.37 | 122 | 49012 | 60866 | 56182067 |
Paraesthesia | 32.45 | 10.37 | 210 | 48924 | 130304 | 56112629 |
Hepatic enzyme increased | 32.19 | 10.37 | 63 | 49071 | 171321 | 56071612 |
Malignant neoplasm progression | 32.13 | 10.37 | 12 | 49122 | 73575 | 56169358 |
Muscle injury | 32.09 | 10.37 | 4 | 49130 | 52496 | 56190437 |
Pancytopenia | 31.77 | 10.37 | 19 | 49115 | 88696 | 56154237 |
Sleep apnoea syndrome | 31.45 | 10.37 | 70 | 49064 | 25991 | 56216942 |
Dysphoria | 31.09 | 10.37 | 29 | 49105 | 4813 | 56238120 |
COVID-19 | 30.38 | 10.37 | 138 | 48996 | 74920 | 56168013 |
Rash | 29.81 | 10.37 | 281 | 48853 | 492766 | 55750167 |
Vision blurred | 29.57 | 10.37 | 147 | 48987 | 82796 | 56160137 |
Intervertebral disc protrusion | 28.15 | 10.37 | 60 | 49074 | 21634 | 56221299 |
Insomnia | 27.99 | 10.37 | 273 | 48861 | 191587 | 56051346 |
Product use issue | 27.26 | 10.37 | 78 | 49056 | 185963 | 56056970 |
Sleep disorder due to general medical condition, insomnia type | 27.24 | 10.37 | 3 | 49131 | 43335 | 56199598 |
Swelling | 26.74 | 10.37 | 113 | 49021 | 239658 | 56003275 |
Therapy interrupted | 26.73 | 10.37 | 65 | 49069 | 25560 | 56217373 |
Vitamin D deficiency | 26.37 | 10.37 | 42 | 49092 | 12128 | 56230805 |
Spinal operation | 25.83 | 10.37 | 32 | 49102 | 7324 | 56235609 |
Pain | 25.02 | 10.37 | 756 | 48378 | 662428 | 55580505 |
Amnesia | 24.93 | 10.37 | 93 | 49041 | 46229 | 56196704 |
Abdominal discomfort | 24.41 | 10.37 | 142 | 48992 | 277132 | 55965801 |
Therapeutic response unexpected | 24.30 | 10.37 | 49 | 49085 | 16995 | 56225938 |
C-reactive protein increased | 24.03 | 10.37 | 20 | 49114 | 78664 | 56164269 |
Suicidal ideation | 23.99 | 10.37 | 107 | 49027 | 57635 | 56185298 |
Cardiac failure | 23.70 | 10.37 | 22 | 49112 | 82071 | 56160862 |
JC polyomavirus test positive | 23.16 | 10.37 | 14 | 49120 | 1204 | 56241729 |
Neurogenic bladder | 23.12 | 10.37 | 20 | 49114 | 3009 | 56239924 |
Blood pressure systolic increased | 22.90 | 10.37 | 4 | 49130 | 40832 | 56202101 |
Hallucination | 22.66 | 10.37 | 94 | 49040 | 49055 | 56193878 |
Visual impairment | 22.66 | 10.37 | 126 | 49008 | 74076 | 56168857 |
Surgery | 22.54 | 10.37 | 71 | 49063 | 32415 | 56210518 |
Pre-existing condition improved | 22.54 | 10.37 | 30 | 49104 | 7368 | 56235565 |
Suspected product quality issue | 22.32 | 10.37 | 8 | 49126 | 204 | 56242729 |
Respiratory arrest | 22.24 | 10.37 | 68 | 49066 | 30557 | 56212376 |
Lumbar radiculopathy | 22.15 | 10.37 | 16 | 49118 | 1855 | 56241078 |
Back disorder | 22.05 | 10.37 | 35 | 49099 | 10078 | 56232855 |
Impaired healing | 20.95 | 10.37 | 27 | 49107 | 86814 | 56156119 |
Balance disorder | 20.80 | 10.37 | 126 | 49008 | 76394 | 56166539 |
Therapy cessation | 20.23 | 10.37 | 61 | 49073 | 27203 | 56215730 |
Loss of consciousness | 19.20 | 10.37 | 162 | 48972 | 109187 | 56133746 |
Intentional product misuse | 18.86 | 10.37 | 92 | 49042 | 51412 | 56191521 |
Formication | 18.53 | 10.37 | 20 | 49114 | 3950 | 56238983 |
Urinary incontinence | 18.14 | 10.37 | 62 | 49072 | 29523 | 56213410 |
Nervousness | 17.96 | 10.37 | 61 | 49073 | 28954 | 56213979 |
Cardio-respiratory arrest | 17.60 | 10.37 | 95 | 49039 | 55226 | 56187707 |
Neuralgia | 17.57 | 10.37 | 53 | 49081 | 23642 | 56219291 |
Progressive multiple sclerosis | 17.54 | 10.37 | 10 | 49124 | 771 | 56242162 |
Mental status changes | 17.51 | 10.37 | 72 | 49062 | 37429 | 56205504 |
Dizziness | 17.28 | 10.37 | 440 | 48694 | 375700 | 55867233 |
Drug dependence | 17.27 | 10.37 | 51 | 49083 | 22482 | 56220451 |
Decreased interest | 17.20 | 10.37 | 17 | 49117 | 3029 | 56239904 |
Central nervous system lesion | 17.16 | 10.37 | 31 | 49103 | 9907 | 56233026 |
Peroneal nerve palsy | 16.62 | 10.37 | 20 | 49114 | 4441 | 56238492 |
Ankle fracture | 16.46 | 10.37 | 41 | 49093 | 16362 | 56226571 |
Temperature intolerance | 16.40 | 10.37 | 27 | 49107 | 8013 | 56234920 |
International normalised ratio increased | 16.38 | 10.37 | 9 | 49125 | 44032 | 56198901 |
Blood creatinine increased | 16.36 | 10.37 | 28 | 49106 | 80163 | 56162770 |
Asthenia | 16.28 | 10.37 | 403 | 48731 | 342570 | 55900363 |
Dysarthria | 16.21 | 10.37 | 73 | 49061 | 39477 | 56203456 |
Respiratory alkalosis | 15.84 | 10.37 | 15 | 49119 | 2536 | 56240397 |
Intervertebral disc degeneration | 15.77 | 10.37 | 37 | 49097 | 14217 | 56228716 |
Pyrexia | 15.73 | 10.37 | 264 | 48870 | 418509 | 55824424 |
Discomfort | 15.67 | 10.37 | 67 | 49067 | 141694 | 56101239 |
Underdose | 15.64 | 10.37 | 51 | 49083 | 23706 | 56219227 |
Hyperhidrosis | 15.27 | 10.37 | 137 | 48997 | 93951 | 56148982 |
Acute kidney injury | 15.02 | 10.37 | 136 | 48998 | 240627 | 56002306 |
Impaired gastric emptying | 14.87 | 10.37 | 28 | 49106 | 9235 | 56233698 |
Disease progression | 14.74 | 10.37 | 45 | 49089 | 105128 | 56137805 |
Haemorrhagic diathesis | 14.70 | 10.37 | 18 | 49116 | 4070 | 56238863 |
Nasopharyngitis | 14.59 | 10.37 | 123 | 49011 | 220836 | 56022097 |
Secondary progressive multiple sclerosis | 14.57 | 10.37 | 11 | 49123 | 1364 | 56241569 |
Gastrointestinal disorder | 14.56 | 10.37 | 50 | 49084 | 112652 | 56130281 |
Panic attack | 14.47 | 10.37 | 45 | 49089 | 20402 | 56222531 |
Cholestasis | 14.32 | 10.37 | 3 | 49131 | 26910 | 56216023 |
Anaemia | 14.24 | 10.37 | 157 | 48977 | 267354 | 55975579 |
Mucosal inflammation | 14.19 | 10.37 | 10 | 49124 | 42800 | 56200133 |
Nausea | 14.16 | 10.37 | 808 | 48326 | 763370 | 55479563 |
Head injury | 14.05 | 10.37 | 51 | 49083 | 25015 | 56217918 |
Pneumonitis | 14.02 | 10.37 | 5 | 49129 | 31559 | 56211374 |
Seizure | 13.60 | 10.37 | 168 | 48966 | 124951 | 56117982 |
Thinking abnormal | 13.48 | 10.37 | 28 | 49106 | 9913 | 56233020 |
Bone marrow failure | 13.41 | 10.37 | 4 | 49130 | 28282 | 56214651 |
Appetite disorder | 13.26 | 10.37 | 22 | 49112 | 6571 | 56236362 |
Device expulsion | 13.23 | 10.37 | 5 | 49129 | 30444 | 56212489 |
Bronchitis | 13.17 | 10.37 | 153 | 48981 | 112158 | 56130775 |
Hypertonia | 13.10 | 10.37 | 17 | 49117 | 4075 | 56238858 |
Fibula fracture | 12.97 | 10.37 | 15 | 49119 | 3195 | 56239738 |
Muscle tightness | 12.95 | 10.37 | 29 | 49105 | 10807 | 56232126 |
Spinal fusion acquired | 12.94 | 10.37 | 3 | 49131 | 14 | 56242919 |
Cervical spinal stenosis | 12.92 | 10.37 | 12 | 49122 | 1980 | 56240953 |
Plasma cell myeloma | 12.88 | 10.37 | 13 | 49121 | 46633 | 56196300 |
Diplopia | 12.76 | 10.37 | 43 | 49091 | 20326 | 56222607 |
Spinal osteoarthritis | 12.76 | 10.37 | 35 | 49099 | 14801 | 56228132 |
Disturbance in attention | 12.55 | 10.37 | 59 | 49075 | 32481 | 56210452 |
Neutrophil count decreased | 12.53 | 10.37 | 15 | 49119 | 49807 | 56193126 |
Loss of control of legs | 12.48 | 10.37 | 10 | 49124 | 1353 | 56241580 |
Stress | 12.38 | 10.37 | 91 | 49043 | 58819 | 56184114 |
Nerve compression | 12.31 | 10.37 | 24 | 49110 | 8120 | 56234813 |
Spinal pain | 12.24 | 10.37 | 30 | 49104 | 11854 | 56231079 |
Ascites | 12.15 | 10.37 | 9 | 49125 | 37535 | 56205398 |
Hepatotoxicity | 12.13 | 10.37 | 6 | 49128 | 31147 | 56211786 |
Hepatocellular injury | 12.13 | 10.37 | 4 | 49130 | 26510 | 56216423 |
Multiple organ dysfunction syndrome | 12.12 | 10.37 | 17 | 49117 | 52753 | 56190180 |
Hyperkalaemia | 12.08 | 10.37 | 16 | 49118 | 50849 | 56192084 |
Cystitis interstitial | 12.03 | 10.37 | 10 | 49124 | 1424 | 56241509 |
Autonomic nervous system imbalance | 11.99 | 10.37 | 13 | 49121 | 2580 | 56240353 |
Blood pressure orthostatic | 11.89 | 10.37 | 4 | 49130 | 84 | 56242849 |
Relapsing-remitting multiple sclerosis | 11.85 | 10.37 | 7 | 49127 | 577 | 56242356 |
Product quality issue | 11.84 | 10.37 | 57 | 49077 | 31679 | 56211254 |
Optic neuritis | 11.80 | 10.37 | 23 | 49111 | 7781 | 56235152 |
Road traffic accident | 11.78 | 10.37 | 52 | 49082 | 27875 | 56215058 |
Myalgia | 11.76 | 10.37 | 171 | 48963 | 131854 | 56111079 |
Fluid replacement | 11.76 | 10.37 | 4 | 49130 | 87 | 56242846 |
Blister | 11.70 | 10.37 | 52 | 49082 | 108835 | 56134098 |
Upper respiratory tract infection | 11.66 | 10.37 | 104 | 49030 | 71184 | 56171749 |
Stomatitis | 11.64 | 10.37 | 60 | 49074 | 120750 | 56122183 |
Acute febrile neutrophilic dermatosis | 11.46 | 10.37 | 13 | 49121 | 2712 | 56240221 |
Back injury | 11.35 | 10.37 | 23 | 49111 | 8003 | 56234930 |
Drug dependence, antepartum | 11.35 | 10.37 | 3 | 49131 | 26 | 56242907 |
Burning sensation | 11.27 | 10.37 | 77 | 49057 | 48619 | 56194314 |
Pulmonary fibrosis | 11.19 | 10.37 | 6 | 49128 | 29752 | 56213181 |
Liver injury | 11.18 | 10.37 | 12 | 49122 | 41836 | 56201097 |
Urosepsis | 11.11 | 10.37 | 36 | 49098 | 16680 | 56226253 |
Normocytic anaemia | 11.09 | 10.37 | 10 | 49124 | 1589 | 56241344 |
Foetal exposure during pregnancy | 11.08 | 10.37 | 8 | 49126 | 33815 | 56209118 |
Micturition urgency | 11.06 | 10.37 | 24 | 49110 | 8757 | 56234176 |
Gastrointestinal haemorrhage | 11.00 | 10.37 | 32 | 49102 | 75919 | 56167014 |
Fibromyalgia | 10.83 | 10.37 | 89 | 49045 | 59514 | 56183419 |
Chills | 10.82 | 10.37 | 137 | 48997 | 102467 | 56140466 |
Illness | 10.80 | 10.37 | 59 | 49075 | 34452 | 56208481 |
Mucosa vesicle | 10.79 | 10.37 | 3 | 49131 | 32 | 56242901 |
CSF immunoglobulin increased | 10.74 | 10.37 | 4 | 49130 | 114 | 56242819 |
Pollakiuria | 10.69 | 10.37 | 47 | 49087 | 25155 | 56217778 |
Crying | 10.67 | 10.37 | 42 | 49092 | 21398 | 56221535 |
Injection site pain | 10.55 | 10.37 | 152 | 48982 | 116966 | 56125967 |
Dysstasia | 10.53 | 10.37 | 39 | 49095 | 19315 | 56223618 |
Infusion site swelling | 10.38 | 10.37 | 22 | 49112 | 7899 | 56235034 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Multiple sclerosis relapse | 112.96 | 13.24 | 70 | 14569 | 11977 | 31670728 |
Multiple sclerosis | 102.51 | 13.24 | 57 | 14582 | 7980 | 31674725 |
Completed suicide | 94.40 | 13.24 | 159 | 14480 | 91355 | 31591350 |
Drug withdrawal syndrome | 72.78 | 13.24 | 64 | 14575 | 18686 | 31664019 |
Muscle spasticity | 69.23 | 13.24 | 39 | 14600 | 5596 | 31677109 |
Potassium wasting nephropathy | 65.37 | 13.24 | 14 | 14625 | 91 | 31682614 |
Muscle spasms | 64.23 | 13.24 | 114 | 14525 | 68204 | 31614501 |
Failure to suspend medication | 59.25 | 13.24 | 17 | 14622 | 403 | 31682302 |
Back pain | 52.45 | 13.24 | 139 | 14500 | 109274 | 31573431 |
Depression | 44.14 | 13.24 | 116 | 14523 | 90699 | 31592006 |
Febrile neutropenia | 39.26 | 13.24 | 5 | 14634 | 121844 | 31560861 |
Intervertebral disc protrusion | 39.24 | 13.24 | 33 | 14606 | 9067 | 31673638 |
Neuralgia | 39.18 | 13.24 | 37 | 14602 | 11829 | 31670876 |
Serotonin syndrome | 37.82 | 13.24 | 45 | 14594 | 18728 | 31663977 |
Pain | 36.05 | 13.24 | 176 | 14463 | 186583 | 31496122 |
Anxiety | 34.21 | 13.24 | 106 | 14533 | 90927 | 31591778 |
Urinary tract infection | 32.18 | 13.24 | 93 | 14546 | 76776 | 31605929 |
Accidental death | 31.80 | 13.24 | 17 | 14622 | 2200 | 31680505 |
Fall | 31.46 | 13.24 | 169 | 14470 | 185920 | 31496785 |
Suspected suicide | 31.40 | 13.24 | 21 | 14618 | 4086 | 31678619 |
Perineal infection | 29.97 | 13.24 | 11 | 14628 | 578 | 31682127 |
Scrotal infection | 29.78 | 13.24 | 11 | 14628 | 589 | 31682116 |
Anaemia | 29.64 | 13.24 | 33 | 14606 | 213489 | 31469216 |
Wrong patient received product | 29.52 | 13.24 | 17 | 14622 | 2542 | 31680163 |
Road traffic accident | 29.33 | 13.24 | 37 | 14602 | 16344 | 31666361 |
Optic nerve operation | 29.17 | 13.24 | 10 | 14629 | 430 | 31682275 |
Drug dependence | 26.98 | 13.24 | 42 | 14597 | 22537 | 31660168 |
Infected dermal cyst | 26.56 | 13.24 | 11 | 14628 | 800 | 31681905 |
Progressive multiple sclerosis | 26.15 | 13.24 | 8 | 14631 | 238 | 31682467 |
Gait disturbance | 24.40 | 13.24 | 85 | 14554 | 77410 | 31605295 |
General physical health deterioration | 24.28 | 13.24 | 11 | 14628 | 113424 | 31569281 |
Neutropenia | 23.84 | 13.24 | 18 | 14621 | 140346 | 31542359 |
Hypoaesthesia | 23.64 | 13.24 | 68 | 14571 | 55954 | 31626751 |
Inadequate analgesia | 23.60 | 13.24 | 15 | 14624 | 2678 | 31680027 |
Tooth injury | 23.02 | 13.24 | 11 | 14628 | 1123 | 31681582 |
Intracranial aneurysm | 22.41 | 13.24 | 12 | 14627 | 1558 | 31681147 |
Thrombocytopenia | 22.14 | 13.24 | 20 | 14619 | 142727 | 31539978 |
Memory impairment | 21.96 | 13.24 | 52 | 14587 | 38078 | 31644627 |
Motor dysfunction | 21.37 | 13.24 | 20 | 14619 | 6319 | 31676386 |
Arteriovenous fistula | 20.93 | 13.24 | 10 | 14629 | 1020 | 31681685 |
Drug abuser | 20.83 | 13.24 | 16 | 14623 | 3864 | 31678841 |
Spinal cord injury cauda equina | 20.76 | 13.24 | 6 | 14633 | 146 | 31682559 |
Somatosensory evoked potentials abnormal | 20.46 | 13.24 | 6 | 14633 | 154 | 31682551 |
Autonomic dysreflexia | 19.96 | 13.24 | 5 | 14634 | 69 | 31682636 |
False positive investigation result | 19.80 | 13.24 | 7 | 14632 | 330 | 31682375 |
Vitamin B6 deficiency | 19.47 | 13.24 | 6 | 14633 | 183 | 31682522 |
Pancytopenia | 19.42 | 13.24 | 8 | 14631 | 87308 | 31595397 |
Dysdiadochokinesis | 19.17 | 13.24 | 6 | 14633 | 193 | 31682512 |
Urobilinogen urine increased | 19.07 | 13.24 | 7 | 14632 | 368 | 31682337 |
Muscular weakness | 19.07 | 13.24 | 70 | 14569 | 65378 | 31617327 |
Unemployment | 17.84 | 13.24 | 4 | 14635 | 33 | 31682672 |
Kidney enlargement | 17.66 | 13.24 | 8 | 14631 | 723 | 31681982 |
Blood folate increased | 17.64 | 13.24 | 6 | 14633 | 252 | 31682453 |
Urine uric acid decreased | 17.37 | 13.24 | 5 | 14634 | 120 | 31682585 |
Insomnia | 17.27 | 13.24 | 88 | 14551 | 94748 | 31587957 |
Urinary sediment abnormal | 17.21 | 13.24 | 5 | 14634 | 124 | 31682581 |
Drug tolerance | 17.14 | 13.24 | 12 | 14627 | 2515 | 31680190 |
Burning sensation | 17.08 | 13.24 | 29 | 14610 | 16718 | 31665987 |
Movement disorder | 16.79 | 13.24 | 23 | 14616 | 10996 | 31671709 |
Pain in extremity | 16.61 | 13.24 | 101 | 14538 | 116102 | 31566603 |
Respiratory arrest | 16.42 | 13.24 | 37 | 14602 | 26220 | 31656485 |
Malignant neoplasm progression | 16.37 | 13.24 | 8 | 14631 | 78990 | 31603715 |
Off label use | 16.31 | 13.24 | 94 | 14545 | 347180 | 31335525 |
Lipomatosis | 16.26 | 13.24 | 6 | 14633 | 320 | 31682385 |
Dermal cyst | 16.17 | 13.24 | 10 | 14629 | 1701 | 31681004 |
Fear of falling | 16.05 | 13.24 | 6 | 14633 | 332 | 31682373 |
Hyponatraemia | 16.03 | 13.24 | 7 | 14632 | 73792 | 31608913 |
Sedation | 15.71 | 13.24 | 30 | 14609 | 18935 | 31663770 |
Respiratory paralysis | 15.48 | 13.24 | 4 | 14635 | 63 | 31682642 |
Decreased vibratory sense | 15.38 | 13.24 | 6 | 14633 | 373 | 31682332 |
Anal haemorrhage | 15.28 | 13.24 | 11 | 14628 | 2407 | 31680298 |
Implant site infection | 15.21 | 13.24 | 8 | 14631 | 1002 | 31681703 |
Migraine | 15.05 | 13.24 | 25 | 14614 | 14155 | 31668550 |
Secondary progressive multiple sclerosis | 15.00 | 13.24 | 6 | 14633 | 399 | 31682306 |
Back injury | 15.00 | 13.24 | 13 | 14626 | 3719 | 31678986 |
Feeling abnormal | 14.98 | 13.24 | 59 | 14580 | 56943 | 31625762 |
Muscle strength abnormal | 14.93 | 13.24 | 4 | 14635 | 73 | 31682632 |
Musculoskeletal stiffness | 14.47 | 13.24 | 47 | 14592 | 41278 | 31641427 |
Gait inability | 14.30 | 13.24 | 29 | 14610 | 19115 | 31663590 |
Cardio-respiratory arrest | 13.96 | 13.24 | 54 | 14585 | 51672 | 31631033 |
Lumbar radiculopathy | 13.93 | 13.24 | 7 | 14632 | 797 | 31681908 |
Tendon pain | 13.79 | 13.24 | 11 | 14628 | 2804 | 31679901 |
Fine motor skill dysfunction | 13.79 | 13.24 | 9 | 14630 | 1681 | 31681024 |
Overdose | 13.66 | 13.24 | 76 | 14563 | 84588 | 31598117 |
Umbilical hernia | 13.64 | 13.24 | 13 | 14626 | 4201 | 31678504 |
Headache | 13.60 | 13.24 | 137 | 14502 | 183515 | 31499190 |
Somnolence | 13.31 | 13.24 | 85 | 14554 | 99360 | 31583345 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Multiple sclerosis relapse | 377.86 | 11.10 | 282 | 49708 | 42735 | 70835719 |
Completed suicide | 238.77 | 11.10 | 507 | 49483 | 226628 | 70651826 |
Multiple sclerosis | 233.74 | 11.10 | 171 | 49819 | 25114 | 70853340 |
Pneumonia aspiration | 161.30 | 11.10 | 209 | 49781 | 62080 | 70816374 |
Drug withdrawal syndrome | 157.88 | 11.10 | 152 | 49838 | 32563 | 70845891 |
Gastrooesophageal reflux disease | 146.80 | 11.10 | 244 | 49746 | 90595 | 70787859 |
Muscle spasms | 134.91 | 11.10 | 320 | 49670 | 153726 | 70724728 |
Somnolence | 129.17 | 11.10 | 389 | 49601 | 215217 | 70663237 |
Coma | 106.84 | 11.10 | 214 | 49776 | 91630 | 70786824 |
Urinary tract infection | 105.75 | 11.10 | 400 | 49590 | 248369 | 70630085 |
Depression | 101.75 | 11.10 | 340 | 49650 | 198634 | 70679820 |
Migraine | 99.66 | 11.10 | 181 | 49809 | 72057 | 70806397 |
Fall | 99.07 | 11.10 | 592 | 49398 | 443504 | 70434950 |
Muscle spasticity | 84.80 | 11.10 | 86 | 49904 | 19603 | 70858851 |
Hypoaesthesia | 83.31 | 11.10 | 268 | 49722 | 153471 | 70724983 |
Suspected suicide | 79.93 | 11.10 | 59 | 49931 | 8775 | 70869679 |
Neutropenia | 79.50 | 11.10 | 41 | 49949 | 257115 | 70621339 |
Febrile neutropenia | 77.14 | 11.10 | 24 | 49966 | 204294 | 70674160 |
General physical health deterioration | 68.09 | 11.10 | 41 | 49949 | 235990 | 70642464 |
Gait disturbance | 67.62 | 11.10 | 284 | 49706 | 184822 | 70693632 |
Pain | 67.09 | 11.10 | 707 | 49283 | 628109 | 70250345 |
Back pain | 66.54 | 11.10 | 371 | 49619 | 270781 | 70607673 |
Autonomic dysreflexia | 60.15 | 11.10 | 19 | 49971 | 406 | 70878048 |
Intervertebral disc protrusion | 56.95 | 11.10 | 73 | 49917 | 21430 | 70857024 |
Thrombocytopenia | 56.70 | 11.10 | 51 | 49939 | 239059 | 70639395 |
Neck pain | 55.62 | 11.10 | 136 | 49854 | 66521 | 70811933 |
Lower respiratory tract infection | 54.97 | 11.10 | 7 | 49983 | 111906 | 70766548 |
Off label use | 53.76 | 11.10 | 306 | 49684 | 742754 | 70135700 |
Potassium wasting nephropathy | 52.77 | 11.10 | 14 | 49976 | 156 | 70878298 |
Product dose omission issue | 51.63 | 11.10 | 295 | 49695 | 217173 | 70661281 |
Withdrawal syndrome | 51.51 | 11.10 | 75 | 49915 | 24829 | 70853625 |
Headache | 49.89 | 11.10 | 626 | 49364 | 579779 | 70298675 |
Pancytopenia | 49.88 | 11.10 | 22 | 49968 | 151085 | 70727369 |
Hand deformity | 48.95 | 11.10 | 3 | 49987 | 86479 | 70791975 |
Contraindicated product administered | 48.71 | 11.10 | 17 | 49973 | 134595 | 70743859 |
Pericarditis | 47.76 | 11.10 | 3 | 49987 | 84702 | 70793752 |
Failure to suspend medication | 46.99 | 11.10 | 16 | 49974 | 436 | 70878018 |
Glossodynia | 43.48 | 11.10 | 5 | 49985 | 86482 | 70791972 |
Stiff person syndrome | 42.52 | 11.10 | 14 | 49976 | 343 | 70878111 |
Acute kidney injury | 41.97 | 11.10 | 182 | 49808 | 474442 | 70404012 |
Drug intolerance | 41.65 | 11.10 | 59 | 49931 | 225628 | 70652826 |
Malignant neoplasm progression | 41.33 | 11.10 | 17 | 49973 | 121722 | 70756732 |
Treatment failure | 40.21 | 11.10 | 26 | 49964 | 144116 | 70734338 |
Memory impairment | 39.30 | 11.10 | 149 | 49841 | 92492 | 70785962 |
Maternal exposure during pregnancy | 37.73 | 11.10 | 17 | 49973 | 115328 | 70763126 |
Anxiety | 37.59 | 11.10 | 275 | 49715 | 220055 | 70658399 |
Feeling abnormal | 37.05 | 11.10 | 198 | 49792 | 142121 | 70736333 |
Muscular weakness | 35.02 | 11.10 | 191 | 49799 | 138145 | 70740309 |
Insomnia | 34.98 | 11.10 | 268 | 49722 | 217538 | 70660916 |
Neuralgia | 34.86 | 11.10 | 68 | 49922 | 28535 | 70849919 |
Cardiac failure | 34.75 | 11.10 | 30 | 49960 | 143511 | 70734943 |
Anaemia | 33.66 | 11.10 | 158 | 49832 | 403265 | 70475189 |
Lumbar radiculopathy | 32.50 | 11.10 | 19 | 49971 | 1907 | 70876547 |
Road traffic accident | 32.44 | 11.10 | 74 | 49916 | 34608 | 70843846 |
Influenza like illness | 31.88 | 11.10 | 110 | 49880 | 65221 | 70813233 |
Progressive multiple sclerosis | 31.11 | 11.10 | 14 | 49976 | 812 | 70877642 |
Drug dependence | 30.97 | 11.10 | 76 | 49914 | 37245 | 70841209 |
Systemic lupus erythematosus | 30.35 | 11.10 | 17 | 49973 | 101885 | 70776569 |
Respiratory arrest | 30.06 | 11.10 | 95 | 49895 | 53838 | 70824616 |
Visual impairment | 29.94 | 11.10 | 124 | 49866 | 80126 | 70798328 |
Infusion related reaction | 29.63 | 11.10 | 59 | 49931 | 197475 | 70680979 |
Hypersensitivity | 29.30 | 11.10 | 75 | 49915 | 229737 | 70648717 |
Joint swelling | 29.04 | 11.10 | 87 | 49903 | 253124 | 70625330 |
Cardio-respiratory arrest | 28.22 | 11.10 | 143 | 49847 | 100534 | 70777920 |
Rheumatoid arthritis | 28.20 | 11.10 | 108 | 49882 | 291697 | 70586757 |
Blood creatinine increased | 27.77 | 11.10 | 36 | 49954 | 142965 | 70735489 |
Neurogenic bladder | 26.95 | 11.10 | 22 | 49968 | 3791 | 70874663 |
Scrotal infection | 26.08 | 11.10 | 11 | 49979 | 545 | 70877909 |
Mucosal inflammation | 25.53 | 11.10 | 8 | 49982 | 67842 | 70810612 |
Urinary incontinence | 25.21 | 11.10 | 71 | 49919 | 37771 | 70840683 |
JC polyomavirus test positive | 25.05 | 11.10 | 14 | 49976 | 1290 | 70877164 |
Optic nerve operation | 25.05 | 11.10 | 10 | 49980 | 430 | 70878024 |
Mental status changes | 24.73 | 11.10 | 99 | 49891 | 63002 | 70815452 |
Drug abuser | 24.14 | 11.10 | 25 | 49965 | 5839 | 70872615 |
False positive investigation result | 23.94 | 11.10 | 12 | 49978 | 886 | 70877568 |
Dysphoria | 23.79 | 11.10 | 22 | 49968 | 4476 | 70873978 |
Platelet count decreased | 23.62 | 11.10 | 57 | 49933 | 178165 | 70700289 |
Dizziness | 23.09 | 11.10 | 457 | 49533 | 463684 | 70414770 |
Tremor | 23.05 | 11.10 | 188 | 49802 | 155436 | 70723018 |
Perineal infection | 22.88 | 11.10 | 11 | 49979 | 742 | 70877712 |
Hyperkalaemia | 22.64 | 11.10 | 25 | 49965 | 106566 | 70771888 |
Vision blurred | 21.95 | 11.10 | 128 | 49862 | 94856 | 70783598 |
Inadequate analgesia | 21.49 | 11.10 | 20 | 49970 | 4102 | 70874352 |
Multiple organ dysfunction syndrome | 21.39 | 11.10 | 27 | 49963 | 108488 | 70769966 |
Paraesthesia | 21.11 | 11.10 | 175 | 49815 | 145362 | 70733092 |
Pyrexia | 20.44 | 11.10 | 303 | 49687 | 606649 | 70271805 |
Spinal operation | 20.43 | 11.10 | 25 | 49965 | 7003 | 70871451 |
Exposure during pregnancy | 20.42 | 11.10 | 19 | 49971 | 87698 | 70790756 |
Back injury | 20.41 | 11.10 | 28 | 49962 | 8774 | 70869680 |
C-reactive protein increased | 20.26 | 11.10 | 29 | 49961 | 110488 | 70767966 |
Gait inability | 20.10 | 11.10 | 76 | 49914 | 47099 | 70831355 |
Bone marrow failure | 19.89 | 11.10 | 5 | 49985 | 49005 | 70829449 |
Peroneal nerve palsy | 19.85 | 11.10 | 22 | 49968 | 5548 | 70872906 |
Surgery | 19.71 | 11.10 | 56 | 49934 | 29933 | 70848521 |
Muscle tightness | 19.52 | 11.10 | 32 | 49958 | 11730 | 70866724 |
Vitamin D deficiency | 19.42 | 11.10 | 33 | 49957 | 12454 | 70866000 |
International normalised ratio increased | 19.38 | 11.10 | 17 | 49973 | 80709 | 70797745 |
Panic attack | 19.37 | 11.10 | 46 | 49944 | 22073 | 70856381 |
Back disorder | 19.26 | 11.10 | 30 | 49960 | 10534 | 70867920 |
Secondary progressive multiple sclerosis | 19.23 | 11.10 | 12 | 49978 | 1355 | 70877099 |
Ascites | 19.08 | 11.10 | 12 | 49978 | 67535 | 70810919 |
Hyponatraemia | 19.07 | 11.10 | 54 | 49936 | 160033 | 70718421 |
Disease progression | 18.55 | 11.10 | 53 | 49937 | 156619 | 70721835 |
Accidental death | 18.55 | 11.10 | 18 | 49972 | 3890 | 70874564 |
Urinary sediment abnormal | 18.54 | 11.10 | 6 | 49984 | 139 | 70878315 |
Dysarthria | 18.51 | 11.10 | 90 | 49900 | 62223 | 70816231 |
Hallucination | 18.42 | 11.10 | 104 | 49886 | 76156 | 70802298 |
Infected dermal cyst | 18.35 | 11.10 | 11 | 49979 | 1156 | 70877298 |
Spinal cord injury cauda equina | 18.26 | 11.10 | 6 | 49984 | 146 | 70878308 |
Amnesia | 18.22 | 11.10 | 79 | 49911 | 52076 | 70826378 |
Toxic epidermal necrolysis | 18.20 | 11.10 | 3 | 49987 | 39554 | 70838900 |
Gastrointestinal haemorrhage | 18.16 | 11.10 | 44 | 49946 | 137364 | 70741090 |
Spinal osteoarthritis | 18.11 | 11.10 | 36 | 49954 | 15312 | 70863142 |
Pain in extremity | 17.99 | 11.10 | 328 | 49662 | 327754 | 70550700 |
Atrial fibrillation | 17.94 | 11.10 | 68 | 49922 | 184280 | 70694174 |
Burning sensation | 17.65 | 11.10 | 79 | 49911 | 52791 | 70825663 |
COVID-19 | 17.44 | 11.10 | 131 | 49859 | 105626 | 70772828 |
Somatosensory evoked potentials abnormal | 16.98 | 11.10 | 6 | 49984 | 183 | 70878271 |
Therapy interrupted | 16.98 | 11.10 | 47 | 49943 | 24755 | 70853699 |
Loss of consciousness | 16.92 | 11.10 | 176 | 49814 | 155540 | 70722914 |
Intervertebral disc degeneration | 16.88 | 11.10 | 33 | 49957 | 13867 | 70864587 |
Balance disorder | 16.81 | 11.10 | 115 | 49875 | 90013 | 70788441 |
Therapy cessation | 16.68 | 11.10 | 57 | 49933 | 33619 | 70844835 |
Hepatic enzyme increased | 16.54 | 11.10 | 56 | 49934 | 156934 | 70721520 |
Hepatocellular injury | 16.36 | 11.10 | 6 | 49984 | 46085 | 70832369 |
Thinking abnormal | 16.36 | 11.10 | 30 | 49960 | 12021 | 70866433 |
Renal impairment | 16.10 | 11.10 | 50 | 49940 | 143887 | 70734567 |
Folliculitis | 16.05 | 11.10 | 5 | 49985 | 42565 | 70835889 |
Angioedema | 16.02 | 11.10 | 14 | 49976 | 66596 | 70811858 |
Melaena | 15.94 | 11.10 | 10 | 49980 | 56345 | 70822109 |
Formication | 15.92 | 11.10 | 18 | 49972 | 4639 | 70873815 |
Sleep disorder due to general medical condition, insomnia type | 15.81 | 11.10 | 3 | 49987 | 35729 | 70842725 |
Asthenia | 15.73 | 11.10 | 428 | 49562 | 457238 | 70421216 |
Serotonin syndrome | 15.65 | 11.10 | 65 | 49925 | 42049 | 70836405 |
Head injury | 15.38 | 11.10 | 56 | 49934 | 34085 | 70844369 |
Urine uric acid decreased | 15.28 | 11.10 | 5 | 49985 | 120 | 70878334 |
Neutrophil count decreased | 15.24 | 11.10 | 22 | 49968 | 83534 | 70794920 |
Arteriovenous fistula | 15.15 | 11.10 | 10 | 49980 | 1243 | 70877211 |
Urobilinogen urine increased | 15.04 | 11.10 | 8 | 49982 | 668 | 70877786 |
Productive cough | 14.92 | 11.10 | 20 | 49970 | 78317 | 70800137 |
Movement disorder | 14.84 | 11.10 | 44 | 49946 | 24085 | 70854369 |
Unemployment | 14.81 | 11.10 | 4 | 49986 | 48 | 70878406 |
Plasma cell myeloma | 14.65 | 11.10 | 18 | 49972 | 73183 | 70805271 |
Ankle fracture | 14.64 | 11.10 | 33 | 49957 | 15311 | 70863143 |
Spinal fusion surgery | 14.61 | 11.10 | 16 | 49974 | 3981 | 70874473 |
Drug hypersensitivity | 14.59 | 11.10 | 263 | 49727 | 262196 | 70616258 |
Product quality issue | 14.51 | 11.10 | 51 | 49939 | 30510 | 70847944 |
Cytomegalovirus infection | 14.41 | 11.10 | 5 | 49985 | 39753 | 70838701 |
Bladder disorder | 14.36 | 11.10 | 23 | 49967 | 8266 | 70870188 |
Intracranial aneurysm | 14.34 | 11.10 | 16 | 49974 | 4064 | 70874390 |
Interstitial lung disease | 14.25 | 11.10 | 33 | 49957 | 104652 | 70773802 |
Vitamin B6 deficiency | 14.11 | 11.10 | 6 | 49984 | 303 | 70878151 |
Paraparesis | 14.09 | 11.10 | 15 | 49975 | 3614 | 70874840 |
Tooth injury | 14.00 | 11.10 | 11 | 49979 | 1794 | 70876660 |
Arterial perforation | 13.96 | 11.10 | 3 | 49987 | 12 | 70878442 |
Loss of control of legs | 13.95 | 11.10 | 11 | 49979 | 1803 | 70876651 |
Dysdiadochokinesis | 13.93 | 11.10 | 6 | 49984 | 313 | 70878141 |
Blood pressure systolic increased | 13.81 | 11.10 | 12 | 49978 | 57247 | 70821207 |
Respiratory paralysis | 13.80 | 11.10 | 4 | 49986 | 63 | 70878391 |
Pneumonitis | 13.71 | 11.10 | 11 | 49979 | 54586 | 70823868 |
Muscle injury | 13.68 | 11.10 | 5 | 49985 | 38489 | 70839965 |
Circulatory collapse | 13.68 | 11.10 | 4 | 49986 | 35470 | 70842984 |
Nausea | 13.61 | 11.10 | 732 | 49258 | 851356 | 70027098 |
Hepatotoxicity | 13.59 | 11.10 | 7 | 49983 | 43979 | 70834475 |
Fibula fracture | 13.59 | 11.10 | 14 | 49976 | 3249 | 70875205 |
Motor dysfunction | 13.47 | 11.10 | 29 | 49961 | 13041 | 70865413 |
Impaired gastric emptying | 13.40 | 11.10 | 24 | 49966 | 9442 | 70869012 |
Sleep apnoea syndrome | 13.36 | 11.10 | 52 | 49938 | 32661 | 70845793 |
Intentional product misuse | 13.35 | 11.10 | 99 | 49891 | 79496 | 70798958 |
Septic shock | 13.27 | 11.10 | 38 | 49952 | 112220 | 70766234 |
Nerve compression | 13.23 | 11.10 | 22 | 49968 | 8156 | 70870298 |
Wrong patient received product | 13.12 | 11.10 | 16 | 49974 | 4464 | 70873990 |
Haemorrhagic diathesis | 13.10 | 11.10 | 18 | 49972 | 5649 | 70872805 |
Underdose | 13.07 | 11.10 | 48 | 49942 | 29335 | 70849119 |
Bedridden | 13.06 | 11.10 | 26 | 49964 | 11072 | 70867382 |
pH urine decreased | 12.95 | 11.10 | 3 | 49987 | 18 | 70878436 |
Nerve injury | 12.95 | 11.10 | 22 | 49968 | 8302 | 70870152 |
Appetite disorder | 12.94 | 11.10 | 20 | 49970 | 6975 | 70871479 |
Haemoglobin decreased | 12.93 | 11.10 | 88 | 49902 | 205071 | 70673383 |
Acute myeloid leukaemia | 12.86 | 11.10 | 3 | 49987 | 30937 | 70847517 |
Lipomatosis | 12.67 | 11.10 | 6 | 49984 | 391 | 70878063 |
Leukopenia | 12.65 | 11.10 | 36 | 49954 | 106524 | 70771930 |
Concussion | 12.60 | 11.10 | 22 | 49968 | 8487 | 70869967 |
Therapeutic product effect decreased | 12.50 | 11.10 | 55 | 49935 | 142963 | 70735491 |
Bronchitis | 12.49 | 11.10 | 132 | 49858 | 117111 | 70761343 |
Implant site infection | 12.37 | 11.10 | 10 | 49980 | 1699 | 70876755 |
Nervousness | 12.33 | 11.10 | 49 | 49941 | 31071 | 70847383 |
Lymphocyte percentage decreased | 12.30 | 11.10 | 16 | 49974 | 4763 | 70873691 |
Tubulointerstitial nephritis | 12.27 | 11.10 | 4 | 49986 | 33072 | 70845382 |
Limb injury | 12.25 | 11.10 | 43 | 49947 | 25709 | 70852745 |
Neurotoxicity | 12.18 | 11.10 | 3 | 49987 | 29823 | 70848631 |
Device allergy | 12.09 | 11.10 | 3 | 49987 | 25 | 70878429 |
Disturbance in attention | 12.06 | 11.10 | 61 | 49929 | 42833 | 70835621 |
Drug dependence, antepartum | 11.99 | 11.10 | 3 | 49987 | 26 | 70878428 |
Osteonecrosis of jaw | 11.98 | 11.10 | 7 | 49983 | 40995 | 70837459 |
Tibia fracture | 11.96 | 11.10 | 16 | 49974 | 4894 | 70873560 |
Renal failure | 11.96 | 11.10 | 81 | 49909 | 188989 | 70689465 |
Epistaxis | 11.94 | 11.10 | 35 | 49955 | 102592 | 70775862 |
Product use issue | 11.93 | 11.10 | 76 | 49914 | 179861 | 70698593 |
Implant site swelling | 11.92 | 11.10 | 6 | 49984 | 447 | 70878007 |
Autonomic nervous system imbalance | 11.91 | 11.10 | 15 | 49975 | 4324 | 70874130 |
Sinus bradycardia | 11.72 | 11.10 | 40 | 49950 | 23583 | 70854871 |
White blood cells urine positive | 11.68 | 11.10 | 17 | 49973 | 5623 | 70872831 |
Haematochezia | 11.68 | 11.10 | 21 | 49969 | 73060 | 70805394 |
Stress | 11.66 | 11.10 | 85 | 49905 | 67881 | 70810573 |
Medical device site pain | 11.66 | 11.10 | 5 | 49985 | 258 | 70878196 |
Agranulocytosis | 11.60 | 11.10 | 7 | 49983 | 40291 | 70838163 |
Crying | 11.50 | 11.10 | 37 | 49953 | 21162 | 70857292 |
Mucosa vesicle | 11.43 | 11.10 | 3 | 49987 | 32 | 70878422 |
Injection site bruising | 11.34 | 11.10 | 55 | 49935 | 37977 | 70840477 |
Blood folate increased | 11.34 | 11.10 | 6 | 49984 | 496 | 70877958 |
Intervertebral disc disorder | 11.26 | 11.10 | 15 | 49975 | 4570 | 70873884 |
Decreased interest | 11.25 | 11.10 | 13 | 49977 | 3428 | 70875026 |
Device failure | 11.24 | 11.10 | 17 | 49973 | 5818 | 70872636 |
Umbilical hernia | 11.21 | 11.10 | 16 | 49974 | 5200 | 70873254 |
Kidney enlargement | 11.19 | 11.10 | 8 | 49982 | 1132 | 70877322 |
T-lymphocyte count decreased | 11.17 | 11.10 | 6 | 49984 | 511 | 70877943 |
None
Source | Code | Description |
---|---|---|
ATC | M03BX02 | MUSCULO-SKELETAL SYSTEM MUSCLE RELAXANTS MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS Other centrally acting agents |
FDA MoA | N0000009918 | Adrenergic alpha2-Agonists |
FDA EPC | N0000175554 | Central alpha-2 Adrenergic Agonist |
MeSH PA | D018663 | Adrenergic Agents |
MeSH PA | D000322 | Adrenergic Agonists |
MeSH PA | D058647 | Adrenergic alpha-2 Receptor Agonists |
MeSH PA | D000316 | Adrenergic alpha-Agonists |
MeSH PA | D000700 | Analgesics |
MeSH PA | D000927 | Anticonvulsants |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D009125 | Muscle Relaxants, Central |
MeSH PA | D009465 | Neuromuscular Agents |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D010276 | Parasympatholytics |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D018689 | Sensory System Agents |
CHEBI has role | CHEBI:35569 | alpha-adrenergic agonists |
CHEBI has role | CHEBI:51371 | muscle relaxants |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Spasticity | indication | 221360009 | |
Muscle spasticity of spinal origin | indication | 416830008 | |
Muscle Spasticity of Cerebral Origin | indication | ||
Low blood pressure | contraindication | 45007003 | |
Bradycardia | contraindication | 48867003 | |
Hepatic failure | contraindication | 59927004 | |
Psychotic disorder | contraindication | 69322001 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.01 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Alpha-2A adrenergic receptor | GPCR | AGONIST | EC50 | 7.07 | CHEMBL | CHEMBL | |||
Alpha-2B adrenergic receptor | GPCR | AGONIST | WOMBAT-PK | CHEMBL | |||||
Alpha-2C adrenergic receptor | GPCR | AGONIST | EC50 | 5.91 | CHEMBL | CHEMBL | |||
Nischarin | Membrane receptor | Ki | 7.55 | CHEMBL | |||||
Alpha-1A adrenergic receptor | GPCR | EC50 | 6.58 | CHEMBL | |||||
Alpha-1B adrenergic receptor | GPCR | EC50 | 6.49 | CHEMBL |
ID | Source |
---|---|
4021025 | VUID |
N0000148492 | NUI |
D00776 | KEGG_DRUG |
64461-82-1 | SECONDARY_CAS_RN |
4021025 | VANDF |
4021027 | VANDF |
C0146011 | UMLSCUI |
CHEBI:63629 | CHEBI |
CHEMBL1079 | ChEMBL_ID |
CHEMBL1200329 | ChEMBL_ID |
DB00697 | DRUGBANK_ID |
C023754 | MESH_SUPPLEMENTAL_RECORD_UI |
5487 | PUBCHEM_CID |
7308 | IUPHAR_LIGAND_ID |
4697 | INN_ID |
6AI06C00GW | UNII |
236460 | RXNORM |
22951 | MMSL |
44068 | MMSL |
5589 | MMSL |
d04102 | MMSL |
006021 | NDDF |
006022 | NDDF |
108461005 | SNOMEDCT_US |
108462003 | SNOMEDCT_US |
373440006 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
tizanidine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0034 | TABLET | 2 mg | ORAL | ANDA | 27 sections |
tizanidine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-4400 | TABLET | 4 mg | ORAL | ANDA | 27 sections |
tizanidine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-2788 | CAPSULE, GELATIN COATED | 2 mg | ORAL | NDA | 26 sections |
tizanidine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-2788 | CAPSULE, GELATIN COATED | 2 mg | ORAL | NDA | 26 sections |
tizanidine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-2789 | CAPSULE, GELATIN COATED | 4 mg | ORAL | NDA | 26 sections |
tizanidine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-2789 | CAPSULE, GELATIN COATED | 4 mg | ORAL | NDA | 26 sections |
tizanidine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-2790 | CAPSULE, GELATIN COATED | 6 mg | ORAL | NDA | 26 sections |
tizanidine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-2790 | CAPSULE, GELATIN COATED | 6 mg | ORAL | NDA | 26 sections |
Tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-5574 | TABLET | 4 mg | ORAL | ANDA | 25 sections |
Tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-6564 | TABLET | 2 mg | ORAL | ANDA | 25 sections |
Tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8274 | TABLET | 4 mg | ORAL | ANDA | 27 sections |
Tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8360 | TABLET | 2 mg | ORAL | ANDA | 27 sections |
tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6418 | TABLET | 4 mg | ORAL | ANDA | 18 sections |
tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6418 | TABLET | 4 mg | ORAL | ANDA | 18 sections |
Tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6898 | TABLET | 4 mg | ORAL | ANDA | 27 sections |
tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-576 | TABLET | 4 mg | ORAL | ANDA | 20 sections |
tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-587 | TABLET | 2 mg | ORAL | ANDA | 18 sections |
tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-863 | TABLET | 2 mg | ORAL | ANDA | 18 sections |
Tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-890 | TABLET | 4 mg | ORAL | ANDA | 22 sections |
TIZANIDINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-220 | TABLET | 2 mg | ORAL | ANDA | 16 sections |
TIZANIDINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-221 | TABLET | 4 mg | ORAL | ANDA | 16 sections |
ZANAFLEX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-756 | CAPSULE | 6 mg | ORAL | NDA | 24 sections |
ZANAFLEX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-871 | CAPSULE | 4 mg | ORAL | NDA | 24 sections |
Tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-171 | TABLET | 2 mg | ORAL | ANDA | 27 sections |
Tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-172 | TABLET | 4 mg | ORAL | ANDA | 27 sections |
TIZANIDINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-126 | TABLET | 2 mg | ORAL | ANDA | 24 sections |
TIZANIDINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-127 | TABLET | 4 mg | ORAL | ANDA | 24 sections |
Zanaflex | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-373 | CAPSULE, GELATIN COATED | 4 mg | ORAL | NDA | 26 sections |
Tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 29300-168 | TABLET | 2 mg | ORAL | ANDA | 26 sections |
Tizanidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 29300-169 | TABLET | 4 mg | ORAL | ANDA | 26 sections |