thiocolchicoside Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4731 602-41-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • thiocolchicoside
  • thiocholshikoside
  • coltramyl
  • muscoril
used in combination with glafenine and meprobamate to tranquilize patients undergoing hysterosalpingography; structure
  • Molecular weight: 563.62
  • Formula: C27H33NO10S
  • CLOGP: -0.40
  • LIPINSKI: 2
  • HAC: 11
  • HDO: 5
  • TPSA: 164.01
  • ALOGS: -3.21
  • ROTB: 7

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Vitamin B12 deficiency 80.30 54.70 12 153 578 2357342
Contraindicated product administered 66.86 54.70 13 152 3008 2354912
Exposure during pregnancy 60.70 54.70 18 147 25201 2332719
Hyperleukocytosis 58.50 54.70 7 158 57 2357863

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
ATC M03BX05 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
Other centrally acting agents
ATC M03BX55 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
Other centrally acting agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Spasticity indication 221360009

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.22 acidic
pKa2 12.23 acidic
pKa3 12.92 acidic
pKa4 13.44 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA A receptor alpha-2/beta-2/gamma-2 Ion channel NEGATIVE MODULATOR IC50 6.89 SCIENTIFIC LITERATURE
GABA A receptor alpha-1/beta-1/gamma-2 Ion channel NEGATIVE MODULATOR IC50 6.82 SCIENTIFIC LITERATURE
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel NEGATIVE MODULATOR IC50 6.70 SCIENTIFIC LITERATURE
GABA-A receptor; anion channel Ion channel IC50 5.72 CHEMBL

External reference:

IDSource
D07276 KEGG_DRUG
C0076456 UMLSCUI
T1X8S697GT UNII
671 INN_ID
DB11582 DRUGBANK_ID
CHEMBL1705373 ChEMBL_ID
9915886 PUBCHEM_CID
C004280 MESH_SUPPLEMENTAL_RECORD_UI
38085 RXNORM
005350 NDDF
735241007 SNOMEDCT_US

Pharmaceutical products:

None