thiocolchicoside 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4731 602-41-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • thiocolchicoside
  • thiocholshikoside
  • coltramyl
  • muscoril
used in combination with glafenine and meprobamate to tranquilize patients undergoing hysterosalpingography; structure
  • Molecular weight: 563.62
  • Formula: C27H33NO10S
  • CLOGP: -0.89
  • LIPINSKI: 2
  • HAC: 11
  • HDO: 5
  • TPSA: 164.01
  • ALOGS: -3.21
  • ROTB: 7

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Poisoning deliberate 65.34 42.94 18 781 7826 34948306

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Poisoning deliberate 53.83 39.20 19 1771 18809 79723789
Palatal oedema 47.47 39.20 10 1780 1421 79741177
Melaena 46.29 39.20 24 1766 60866 79681732
Urticaria 46.16 39.20 36 1754 185165 79557433
Erythema 42.27 39.20 37 1753 223253 79519345
Hepatocellular injury 39.76 39.20 20 1770 47573 79695025

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M03BX05 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
Other centrally acting agents
ATC M03BX55 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
Other centrally acting agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Spasticity indication 221360009




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.22 acidic
pKa2 12.23 acidic
pKa3 12.92 acidic
pKa4 13.44 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel NEGATIVE MODULATOR IC50 6.70 SCIENTIFIC LITERATURE
GABA A receptor alpha-2/beta-2/gamma-2 Ion channel NEGATIVE MODULATOR IC50 6.89 SCIENTIFIC LITERATURE
GABA A receptor alpha-1/beta-1/gamma-2 Ion channel NEGATIVE MODULATOR IC50 6.82 SCIENTIFIC LITERATURE
GABA-A receptor; anion channel Ion channel IC50 5.72 CHEMBL

External reference:

IDSource
D07276 KEGG_DRUG
CHEBI:94557 CHEBI
CHEMBL1705373 ChEMBL_ID
C004280 MESH_SUPPLEMENTAL_RECORD_UI
671 INN_ID
DB11582 DRUGBANK_ID
T1X8S697GT UNII
38085 RXNORM
005350 NDDF
1173015002 SNOMEDCT_US
735241007 SNOMEDCT_US
C0076456 UMLSCUI
9915886 PUBCHEM_CID

Pharmaceutical products:

None