tetrazepam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 2614 10379-14-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tetrazepam
  • myolastan
  • Molecular weight: 288.78
  • Formula: C16H17ClN2O
  • CLOGP: 3.68
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 32.67
  • ALOGS: -3.83
  • ROTB: 1

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,EIF2AK3,GRK2,MAPK7,PDK1,PDK2,PDK4 7
kinase-selectivity-class EIF2AK3,GRK2,TTK 3
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cross sensitivity reaction 94.48 38.14 19 1530 2838 90624060
Dermatitis contact 83.08 38.14 23 1526 13572 90613326
Occupational exposure to product 61.27 38.14 13 1536 2518 90624380
Eczema 55.78 38.14 24 1525 52846 90574052
Skin test positive 54.82 38.14 10 1539 890 90626008
Eczema eyelids 49.43 38.14 8 1541 350 90626548
Junctional ectopic tachycardia 45.69 38.14 7 1542 214 90626684
Paranasal sinus inflammation 44.80 38.14 8 1541 631 90626267
Sinobronchitis 44.06 38.14 8 1541 693 90626205
Wrong technique in product usage process 42.93 38.14 22 1527 71549 90555349
Osteoporosis postmenopausal 42.03 38.14 7 1542 366 90626532
Peripheral nerve lesion 40.31 38.14 7 1542 470 90626428
Foramen magnum stenosis 39.18 38.14 6 1543 183 90626715
Radial nerve palsy 38.58 38.14 7 1542 604 90626294

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Logorrhoea 105.95 63.21 20 550 2787 42617978
Transposition of the great vessels 94.25 63.21 14 556 451 42620314
Vestibular disorder 81.26 63.21 14 556 1163 42619602
Toxicity to various agents 77.81 63.21 44 526 229092 42391673

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 116.34 36.15 68 1081 480487 110107663
Logorrhoea 99.46 36.15 20 1129 4937 110583213
Dermatitis contact 93.91 36.15 23 1126 13930 110574220
Cross sensitivity reaction 91.31 36.15 19 1130 5548 110582602
Occupational exposure to product 82.08 36.15 13 1136 826 110587324
Vestibular disorder 73.45 36.15 14 1135 2618 110585532
Skin test positive 55.05 36.15 10 1139 1439 110586711
Eczema eyelids 52.01 36.15 8 1141 419 110587731
Psychomotor skills impaired 49.31 36.15 12 1137 7046 110581104
Wrong technique in product usage process 49.24 36.15 22 1127 87326 110500824
Disturbance in attention 42.72 36.15 18 1131 61977 110526173
Coordination abnormal 42.04 36.15 14 1135 25214 110562936
Agoraphobia 40.96 36.15 7 1142 709 110587441
Suicide attempt 39.71 36.15 20 1129 103374 110484776
Eczema 36.90 36.15 17 1132 72276 110515874

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M03BX07 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
Other centrally acting agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D009125 Muscle Relaxants, Central
MeSH PA D009465 Neuromuscular Agents
MeSH PA D018373 Peripheral Nervous System Agents

Related Drugs by ATC class:

M03BX Other centrally acting agents 9 drugs
baclofencyclobenzaprineeperisonefenyramidolmephenesinpridinolthiocolchicosidetizanidinetolperisone

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.8 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07277 KEGG_DRUG
C5831153 UMLSCUI
CHEBI:135198 CHEBI
CHEMBL2105527 ChEMBL_ID
DB13324 DRUGBANK_ID
C005245 MESH_SUPPLEMENTAL_RECORD_UI
25215 PUBCHEM_CID
2182 INN_ID
FO92091VP8 UNII
37985 RXNORM
005346 NDDF
698845008 SNOMEDCT_US

Pharmaceutical products:

None